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Dissertations / Theses on the topic 'Antineoplastic agents: pharmacology. Cancer'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

Martinsson, Petra 1974. "Pharmacological studies of CHS 828 and etoposide induced tumour cell death /." Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2001. http://publications.uu.se/theses/91-554-5157-8/.

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2

Yang, Xiaotong, and 楊曉彤. "The anticancer mechanisms of polysaccharide peptide (PSP) derived fromthe Chinese medicinal fungus coriolus versicolor." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2004. http://hub.hku.hk/bib/B31246229.

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3

Chen, Alina. "New polyamine analogues as potential antineoplastic agents." Scholarly Commons, 2000. https://scholarlycommons.pacific.edu/uop_etds/2680.

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The naturally occurring polyamines play an essential role in cell growth and proliferation. The levels of polyamines have been shown to increase in rapidly proliferating cancer cells. Therefore, compounds that inhibit enzymes in polyamine biosynthetic pathway may have therapeutic potential. Compounds capable of providing both in vitro and in vivo inhibition of almost all enzymes in the polyamine biosynthetic pathway are known. An exception is the lack of an agent that inhibits spermidine/spermine N 1 -acetyltransferase (SSAT), the rate-limiting enzyme in the catabolism of polyamines. The desig

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4

Nylén, Urban D. "Interactive antiproliferative mechanisms when 5-fluorouracil is combined with cisplatin or ionizing radiation : an in vivo and in vitro experimental study /." Stockholm, 2000. http://diss.kib.ki.se./2000/91-628-4480-6/.

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5

Parker-, Johnson Kitani A. "An evaluation of novel antineoplastic agent on prostate cancer." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2003. http://digitalcommons.auctr.edu/dissertations/3074.

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This study examines the effects of novel antineoplastic agents(isochalcones) on human metastatic prostate cancer cell lines by screening cells for their relative antiproliferative effects, measuring the protein expression levels of specific oncogenes by Western blotting, and evaluating an array of genes ( 5184) to determine possible mechanisms of action of these novel isochalcones. The array data were supported by real-time polymerase chain reaction (PCR) techniques. The antineoplastic agents were screened in human metastatic prostate cancer cell lines (LNCaP, DU145, PC-3, and MDA-PCa-2b) and

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6

Zhu, Yanting. "Exploring alternative cytotoxic strategies for cancer treatment." HKBU Institutional Repository, 2014. https://repository.hkbu.edu.hk/etd_oa/65.

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Triggering direct cytotoxicity has been the most common strategy for developing cancer treatments. The cytotoxic regimens currently used in the clinic mainly include radiation therapy, classic chemotherapeutic drugs (e.g. DNA damaging drugs and anti-mitotic drugs) and selected new targeted drugs. Although these therapies are the standard of care for most cancer patients, they suffer significant limitations: responses to these therapies vary significantly between cancer types and patients; sensitive cancers tend to acquire resistance; and they cause serious toxicity, particularly to dividing ce

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7

Arthasery, Phyllis Pinney Kevin G. "Discovery and development of unique small molecule chromene based ligands and combretastatin analogs as potential second generation vascular disrupting agents towards cancer chemotherapy." Waco, Tex. : Baylor University, 2005. http://hdl.handle.net/2104/3020.

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8

陳志強. "中醫藥抗腫瘤復發轉移文獻研究". HKBU Institutional Repository, 2012. http://repository.hkbu.edu.hk/etd_ra/1336.

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9

Allan, Lucy Jane. "Development and pharmacology of mitomycin C albumin microspheres." Thesis, University of Strathclyde, 1994. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319281.

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10

Williams, Elizabeth G. L. "Total synthesis of novel analogues and hybrids of the anti-cancer agents dictyostatin and discodermolide." Thesis, University of Cambridge, 2012. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.610776.

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11

Johansson, Magnus. "Cloning and characterization of human deoxyribonucleoside kinases : phosphorylation of anti-cancer and anti-viral nucleoside analogs /." Stockholm, 1997. http://diss.kib.ki.se/1997/91-628-2696-4.

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12

Wiltshire, Timothy D. "DNA damage response activated by anti-cancer agent, irofulven." Morgantown, W. Va. : [West Virginia University Libraries], 2007. https://eidr.wvu.edu/etd/documentdata.eTD?documentid=5390.

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Thesis (Ph. D.)--West Virginia University, 2007.<br>Title from document title page. Document formatted into pages; contains ix, 227 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references.

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13

Gomes, Erica Manuela Tong Alex W. "Anti-tumor properties of CD40 ligand when delivered as a transgene by the conditional replicative oncolytic adenovirus AdEH to breast cancer cells." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4901.

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14

Laane, Edward. "Cell death mechanisms of anti-cancer agents and treatment response in acute leukemia /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-854-1/.

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15

Zhu, Chaoyong. "Deoxyribonucleoside kinases in nuclear and mitochondrial DNA precursor synthesis : phosphorylation of anti-cancer nucleoside analogs in different subcellular compartments /." Stockholm, 2000. http://diss.kib.ki.se/2000/91-628-4367-2/.

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16

Kinkade, Rebecca. "Rb-Raf-1 interaction as a therapeutic target for proliferative disorders." [Tampa, Fla] : University of South Florida, 2008. http://purl.fcla.edu/usf/dc/et/SFE0002426.

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17

Lee, Jisun. "Omega-3 fatty acid derived endocannabinoids as anticancer agents in breast cancer." Thesis, University of Aberdeen, 2015. http://digitool.abdn.ac.uk:80/webclient/DeliveryManager?pid=225938.

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Many studies have reported the anti-cancer effects of n-3 long chain polyunsaturated fatty acids (n-3 LCPUFAs). In this study, the anticancer effects of n-3 LCPUFAs and their derivatives, n-3 n-acyl ethanolamides (n-3 NAEs) were investigated in MCF-7 and MDA-MB-231 breast cancer cell lines. The focus was on their effects on cell proliferation, the role of CB1 and CB2 receptors, the effects of their main metabolising enzyme, FAAH, and which molecular signalling pathways are involved. In addition, the effects on the redox system, particularly in the modulation of redox genes, proteins and enzyme

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18

Howard, Edward William. "The potential clinical applications of garlic-derived S-allylmercaptocysteine in the treatment of hormone refractory prostate cancer." View the Table of Contents & Abstract, 2007. http://sunzi.lib.hku.hk/hkuto/record/B38165156.

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19

Gréen, Henrik. "Pharmacogenetic studies of paclitaxel in ovarian cancer : focus on interindividual differences in pharmacodynamics and pharmacokinetics /." Linköping : Univ, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-8134.

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20

Jaganath, Yatish. "Advances in platinum-amine chemotherapeutic agents : their chemistry and applicationc." Thesis, Nelson Mandela Metropolitan University, 2009. http://hdl.handle.net/10948/d1021222.

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The research conducted in this study focussed on advancing the knowledge database of diamineplatinum complexes on two frontiers: 1) the development of novel anticancer complexes, and 2) improvements in their synthetic chemistry. Novel square-planar dichloro and oxalato platinum(II) complexes were synthesized as potential anticancer agents in accordance with a comprehensive set of factors identified as being significant in optimizing such action. The nonleaving ligands consisted of asymmetric chelating chiral diamines of the form 1- (1-R-imidazol-2yl)(R')methanamine (R representing methyl, buty

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21

Mo, Hao. "Targeting of the Myc pathway as a novel approach for cancer therapy /." Stockholm, 2006. http://diss.kib.ki.se/2006/91-7140-936-X/.

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22

Zhou, Chun. "Effect of FTY720 on the growth and invasion ability of androgenindependent prostate cancer cells." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B31685742.

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23

Xie, Yanqi. "SEMISYNTHETIC AURONES: A FAMILY OF NEWLY DISCOVERED TUBULIN INHIBITORS AS ANTINEOPLASTIC AGENTS." UKnowledge, 2019. https://uknowledge.uky.edu/biochem_etds/44.

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Aurones belong to an uncommon class of plant flavonoids that provide the bright yellow coloration of some ornamental flowers and that possess a range of biological activities. Structure-activity relationships (SAR) in the aurone pharmacophore identified heterocyclic variants of the (Z)-2-benzylidene-6-hydroxybenzofuran-3(2H)-one scaffold that possessed low nanomolar in vitro potency in cell proliferation assays using various cancer cell lines, in vivo potency in prostate cancer PC-3 xenograft and zebrafish models, selectivity for the colchicine-binding site on tubulin, and absence of appreciab

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24

Wang, Ying. "Exploring action mechanisms of chemotherapeutic agents in human cancer cell lines by biochemical and proteomic approaches." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36633306.

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25

Dewa, Shaliza Zaini. "Novel 3,3-dialkyldiaziridine platinum and palladium complexes." Thesis, University of Sussex, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296548.

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26

Lewis, Andrew Martin. "The synthesis and biological evaluation of a novel anticancer small molecule." Thesis, University of Cambridge, 2013. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.607805.

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27

Chiang, Yiu Chun. "ICG-001 inhibits metastasis of nasopharyngeal carcinoma via miRNA-134/β1-integrin axis". HKBU Institutional Repository, 2020. https://repository.hkbu.edu.hk/etd_oa/879.

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Background: ICG-001, an antagonist of CBP (CREB-binding protein), has been demonstrated to exert anti-tumor activity via the modulation of the Wnt signalling pathway. It has previously been demonstrated that miRNAs play an important role in ICG-001-mediated tumor suppression. In the present study, the role of miRNA-134 and 1-integrin in ICG-001-mediated anti-tumor activity in nasopharyngeal carcinoma (NPC) was examined. Methods: NPC cell lines including C666-1, HONE-1 and HK-1 were used in this study. RT-PCR and Western blot were used to study the expression of miRNA-134 and the protein expres

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28

McPhee, Mark Matthew. "Design, synthesis and biophysical evaluation of metallo-regulated DNA-cleaving agents /." Digital version accessible at:, 1999. http://wwwlib.umi.com/cr/utexas/main.

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29

Rambalee, Veneesha. "Effects of 2-methoxyestradiol, an endogenous estrogen metabolite, on SNO and WHCO3 oesophageal cancer cell growth." Diss., Access to E-Thesis, 2003. http://upetd.up.ac.za/thesis/available/etd-09272005-143729/.

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30

Zhou, Chun, and 周純. "Effect of FTY720 on the growth and invasion ability of androgenindependent prostate cancer cells." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B31685742.

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31

Moniodis, Joseph John. "Studying the DNA binding of a non-covalent analogue of the trinuclear platinum anticancer agent BBR3464." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0008.

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[Truncated abstract] The Phase II clinical candidate, [(trans-Pt(NH3)2Cl)2{μ-trans-Pt(NH3)2(H2N(CH2)6NH2)2}]4+ (BBR3464 or 1,0,1/t,t,t) shows a unique binding profile when compared to the anticancer agent cis-[Pt(NH3)2Cl2] (cisplatin) and dinuclear platinum complexes of the general formula [(trans-Pt(NH3)2Cl)2(H2N(CH2)nNH2)]2+. There is evidence that the increased efficacy of 1,0,1/t,t,t results from the presence of the charged central linker, which can alter the mode of binding to DNA. This alternate binding mode may be due to an electrostatic and hydrogen bonding association of the central p

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32

Chu, Qingjun. "S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), water soluble garlic derivatives, suppress growth and invasion of androgen-independent prostate cancer, under in vitro and in vivo conditions." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36749540.

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33

Min, Junxia. "Sphingolipid metabolic enzymes modulate anticancer drug resistance." Diss., Columbia, Mo. : University of Missouri-Columbia, 2006. http://hdl.handle.net/10355/5899.

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Thesis (Ph. D.)--University of Missouri-Columbia, 2006.<br>The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public.pdf file. Title from title screen of research.pdf file viewed on (March 5, 2007) Vita. Includes bibliographical references.

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34

Miranda, Maria Graciela Pinney Kevin G. "Design, synthesis and biological evaluation of novel serotonin reuptake inhibitors and novel derivatives of a nitrogen-containing combretastatin analog." Waco, Tex. : Baylor University, 2006. http://hdl.handle.net/2104/4819.

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35

Hui, Chun-fai Ivan. "Study of mammalian target of rapamycin (mTOR) signaling and the effects of its specific inhibitors in hepatocellular carcinoma." Click to view the E-thesis via HKUTO, 2007. http://sunzi.lib.hku.hk/HKUTO/record/B39558459.

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36

Sriram, Madhavi Pinney Kevin G. "Design, synthesis, biochemical and biological evaluation of benzocyclic and enediyne analogs of combretastatins as potential tubulin binding ligands in the treatment of cancer." Waco, Tex. : Baylor University, 2007. http://hdl.handle.net/2104/5121.

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37

Chu, Qingjun, and 褚慶軍. "S-allylcysteine (SAC) and S-allylmercaptocysteine (SAMC), water soluble garlic derivatives, suppress growth and invasion of androgen-independent prostate cancer, under in vitro and in vivo conditions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B37935653.

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38

Howard, Edward William. "The potential clinical applications of garlic-derived S-allylmercaptocysteine in the treatment of hormone refractory prostatecancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2007. http://hub.hku.hk/bib/B38834856.

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39

Wang, Ying, and 王穎. "Exploring action mechanisms of chemotherapeutic agents in human cancercell lines by biochemical and proteomic approaches." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2006. http://hub.hku.hk/bib/B36633306.

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40

Xu, Yang. "Proteomic and biochemical characterization of the anti-cancer mechanism of tubeimoside-1 extracted from the Chinese herbal medicine "Tu bei mu"." Click to view the E-thesis via HKUTO, 2010. http://sunzi.lib.hku.hk/hkuto/record/B44135968.

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41

Liu-Chen, Xinyue. "Novel strategies to treat human cancer cells : resistant to thymidylates synthase inhibitors /." Access full-text from WCMC:, 1999. http://proquest.umi.com/pqdweb?did=1432807601&sid=7&Fmt=2&clientId=8424&RQT=309&VName=PQD.

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42

Brauns, Seth Clint Aron. "The effects of selected proline-based cyclic dipeptides on growth and induction of apoptosis in cancer cells." Thesis, University of Port Elizabeth, 2004. http://hdl.handle.net/10948/396.

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An increasing number of cyclic dipeptides (CDPs) have been shown to exhibit important biological activity including antifungal, antibacterial, anticonvulsant and immunomodulatory activity. Furthermore, some CDP derivatives have been shown to exhibit antitumour activity in vitro and in vivo. Several proline-based CDPs that exhibit biological activity have been detected in various processed foods and beverages. In the present study, the potential of seven proline-based CDPs to inhibit cancer cell growth was investigated in HT-29 (colon), HeLa (cervical), MCF-7 (breast) and WHCO3 (oesophageal) ca

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43

Schuler, Aaron D. "Development of sirtuin and calmodulin-dependent protein kinase inhibitors as anti-cancer therapeutics /." Thesis, Connect to this title online; UW restricted, 2006. http://hdl.handle.net/1773/8491.

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44

Wong, Suk-yu. "Study of anti-cancer and anti-viral activities of lanthanide and vanadium complexes." View the Table of Contents & Abstract, 2006. http://sunzi.lib.hku.hk/hkuto/record/B36584599.

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45

Jodrell, Duncan Ian. "The pharmacology and toxicology of novel thymidylate synthase inhibitors, potential new anticancer agents." Thesis, University of Southampton, 1990. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.296525.

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46

Palmebäck, Wegman Pia. "Studies of tamoxifen resistance in breast cancer /." Linköping : Univ, 2007. http://www.bibl.liu.se/liupubl/disp/disp2007/med987s.pdf.

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47

Rheeders, Wilmarie. "Aspects of the usage of antineoplastic and immunomodulating agents in a section of the private health care sector / Wilmarie Rheeders." Thesis, North-West University, 2008. http://hdl.handle.net/10394/4216.

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48

Edler, David. "Thymidylate synthase expression in colorectal cancer : its role as a prognostic factor and a predictive factor in adjuvant 5-fluorouracil-based chemotherapy /." Stockholm, 2001. http://diss.kib.ki.se/2001/91-628-4651-5/.

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49

Brink, Susanna. "Structure-activity relationships of titanocene complexes with antitumor properties." Pretoria : [s.n.], 2003. http://upetd.up.ac.za/thesis/available/etd-09052005-101713/.

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50

Wong, Lai-Ming Ella. "Iron and ruthenium complexes with nitrogen and oxygen donor ligands for anti-cancer and anti-viral studies." Click to view the E-thesis via HKUTO, 2006. http://sunzi.lib.hku.hk/hkuto/record/B3587742X.

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