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Journal articles on the topic 'Aromatic hydroxy compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Rubtsova, Daria D., Alexandra A. Bobyleva, Daria D. Lezhnina, Sofia V. Polikarpova, Polina A. Rozhkova, and Vladimir L. Gein. "Synthesis of 5-aryl-3-hydroxy-1-(2-hydroxypropyl)-4-(furyl-2-carbonyl)- 3-pyrrolin-2-ones and 5-aryl-3-hydroxy-1-(3-hydroxypropyl)- 4-(furyl-2-carbonyl)-3-pyrrolin-2-ones." Butlerov Communications 63, no. 9 (2020): 26–30. http://dx.doi.org/10.37952/roi-jbc-01/20-63-9-26.

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In this work, pyrrolidin-2-ones and their derivatives are considered as a promising class of non-aromatic heterocyclic compounds. Their structure is found in the nuclei of many natural products and biologically active molecules. In pharmacy the possibility of introducing various substituents into the nucleus of pyrrolidin-2-ones is a great importance for the synthesis of new medicinal molecules with improved biological activity. Nowadays the synthesis of new active compounds by introducing various substituents at the C1-, C4- and C5-position of 3-hydroxy-3-pyrrolin-2-one has been little studie

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2

Oliveira, Raquel, Nelson Pereira, Dulce Geraldo, and Fátima Bento. "Reactivity of hydroxy-containing aromatic compounds towards electrogenerated hydroxyl radicals." Electrochimica Acta 105 (August 2013): 371–77. http://dx.doi.org/10.1016/j.electacta.2013.04.124.

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3

Jia, Yong Hui. "Technical Study on Relationship between Terpene Phenolic Compounds and Health." Advanced Materials Research 518-523 (May 2012): 529–32. http://dx.doi.org/10.4028/www.scientific.net/amr.518-523.529.

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The hydroxy derivatives of aromatic hydrocarbons which have hydroxyl getup directly attached to the ring are called phenols. Small amounts of water dissolved in phenol lower the melting point to below the room temperature. This paper summarized the bioactivities and safety issues of Terpene Phenolic, and its functions, biosynthetic mechanisms, characteristics and clearing strategies of terpene phenolic compounds.

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4

Yang, Jian Qiong, Hai Liu, Lei Peng, and Guo An Luo. "Study on Terpene Phenolic Compounds and its Health Effects." Advanced Materials Research 1004-1005 (August 2014): 924–27. http://dx.doi.org/10.4028/www.scientific.net/amr.1004-1005.924.

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Hydroxy derivatives of aromatic hydrocarbons, have hydroxyl getup directly attached to the ring, which is called phenols. This paper study the bioactivities and safety issues of Terpene Phenolic and its functions, characteristics and clearing strategies of terpene phenolic compounds, so as its biosynthetic mechanisms. The results show that the small amounts of water dissolved in phenol lower the melting point to below the room temperature.

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5

BONNEAU-GUBELMANN, I., M. MICHEL, B. BESSON, S. RATTON, and J. R. DESMURS. "ChemInform Abstract: Carboxylation of Hydroxy Aromatic Compounds." ChemInform 28, no. 13 (2010): no. http://dx.doi.org/10.1002/chin.199713293.

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6

Brousmiche, Darryl W., Alexander G. Briggs, and Peter Wan. "ChemInform Abstract: Photochemistry of Hydroxy Aromatic Compounds." ChemInform 32, no. 21 (2010): no. http://dx.doi.org/10.1002/chin.200121238.

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7

Kamble, Pallavi, and Sailesh Wadher. "SYNTHESIS, IN VITRO ANTIOXIDANT AND ANTIMICROBIAL EVALUATION OF 3-HYDROXY CHROMONE DERIVATIVES." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 259. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22984.

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Objective: The objective of the present study was to synthesize a series of 3-hydroxychromone derivatives and to evaluate its in vitro antioxidant and antimicrobial activities.Methods: 3-hydroxy chromones were synthesized using an algar flynn oyamada method which includes oxidative cyclization of 2-hydroxy chalcones in basic solution by hydrogen peroxide. 2-hydroxy chalcones were synthesized by Claisen-Schmidt condensation of substituted 2-hydroxy acetophenones with substituted aromatic aldehydes using polyethylene glycol-400 as a recyclable solvent. The synthesized compounds were evaluated fo

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8

Fukuoka, S., H. Ogawa, and T. Watanabe. "Preparation of aromatic carbonates by catalytic carbonylation of aromatic hydroxy compounds." Zeolites 11, no. 1 (1991): 89. http://dx.doi.org/10.1016/0144-2449(91)80380-i.

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9

Kottapalle, Gajanan D., Nagesh J. Deshmukh, and Avinash T. Shinde. "Growth Inhibitory Properties of Synthetic Chalcones." Current Bioactive Compounds 16, no. 6 (2020): 892–99. http://dx.doi.org/10.2174/1573407215666190401202553.

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Background: In the present study, chalcones were synthesized from 2-hydroxy-1- acetonaphthone and substituted aromatic aldehydes were synthesized by Claisen Schmidt condensation reaction using potassium hydroxide as a base. The synthesized chalcones were purified by recrystallization from ethanol and evaluated for antibacterial activity by well diffusion method. The antibacterial activity was evaluated against Bacillus licheniformis, Bacillus species, Escherichia coli and Staphylococcus aureus using Ciprofloxacin as a standard. Methods: The target molecules were prepared by reacting 2-hydroxy-

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10

S.C., Das. "Ion-exchange studies of resin copolymers derived from aromatic hydroxy compounds." Journal of Indian Chemical Society Vol. 77, Feb 2000 (2000): 66–69. https://doi.org/10.5281/zenodo.5862154.

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Department of Chemistry, S. V. M. College, Jagatsinghpur-754 103, India <em>Manuscript received 18 September 1998, revised 22 June 1999, accepted 20 August 1999</em> The ion-exchange capacity, effect of electrolytes on metal uptake, rate of metal uptake and distribution of metal ion at different pHs of resin copolymers derived from thiosemicarbazone derivatives of phenolic compounds shows higher order than the resin copolymer derived from semicarbazone derivatives. The results are compared with the commercial ion-exchangers.

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11

Lu, Shan, Siegfried Draeger, Barbara Schulz, et al. "Bioactive Aromatic Derivatives from Endophytic Fungus, Cytospora sp." Natural Product Communications 6, no. 5 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600518.

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Two new benzyl γ-butyrolactone analogues, ( R)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (1) and its 6-acetate (2), and a new naphthalenone derivative (8), together with eight additional known aromatic derivatives, ( S)-5-(( S)-hydroxy(phenyl)-methyl)dihydrofuran-2(3H)-one (3), ( S)-5-benzyl-dihydrofuran-2(3H)-one (4), 5-phenyl-4-oxopentanoic acid (5), γ-oxo-benzenepentanoic acid methyl ester (6), 3-(2,5-dihydro-4-hydroxy-5-oxo-3-phenyl-2-furyl)propionic acid (7), (3 R)-5-methylmellein (9), integracins A (10) and B (11) were isolated from Cytospora sp., an endophytic fungus isolate

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12

Wang, Fu-Xiang, Shao-Da Zhou, Chengming Wang, and Shi-Kai Tian. "N-Hydroxy sulfonamides as new sulfenylating agents for the functionalization of aromatic compounds." Organic & Biomolecular Chemistry 15, no. 25 (2017): 5284–88. http://dx.doi.org/10.1039/c7ob01390f.

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13

Eraghi Kazzaz, Armin, Zahra Hosseinpour Feizi, and Pedram Fatehi. "Grafting strategies for hydroxy groups of lignin for producing materials." Green Chemistry 21, no. 21 (2019): 5714–52. http://dx.doi.org/10.1039/c9gc02598g.

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14

Journal, Baghdad Science. "Synthesis of Some new 2-(4-Aryliminophenoxy)N-Arylacetamide Via p-hydroxy benzaldehyde." Baghdad Science Journal 11, no. 2 (2014): 486–90. http://dx.doi.org/10.21123/bsj.11.2.486-490.

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Chloroacetamide derivatives (2a-g) have been prepared through reaction of chloroacetyl chloride(1) (which prepared by the reaction of chloroacetic acid with thionyl chloride) with primary aromatic amines and sulfa compounds to afford compounds (2a-g) which then reacted with p-hydroxy benzaldehyde via Williamson reaction to obtaine the new compounds 2-(4-formyl phenoxy)-N-aryl acetamide (3a-g). Finally , compounds (3a-g) will be use as a good synthon to prepare the Schiff bases represented by compounds 2-(4-aryliminophenoxy)-N-arylacetamide (4a-g). through , reaction with some primary aromatic

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15

Aboud, Wasfi, Harith Y. Mahmood, Rasha M. Othman, and Wasan M. Shaker. "The NMR Study and Antimicrobial Activity of Some Schiff Bases Derived From Sulphonamide Drug." JOURNAL OF ADVANCES IN CHEMISTRY 12, no. 2 (2016): 4009–17. http://dx.doi.org/10.24297/jac.v12i2.2157.

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Some Schiff base compounds derived from sulfonamide drug were synthesized by reaction of 4-aminobenzenesulfonamide with aromatic aldehydes (2-hydroxy-1-naphthaldehyde, 3,4-dihydroxybenzaldehyde and 2-hydroxy benzaldehyde) in good yields. Characterization of synthesized compound was carried by elemental analysis, IR, 1H,13C, HSQC and HMBC- NMR spectroscopy. The synthesized compounds were screened for their antibacterial activity against Staphylococcus aureus, Streptococcus sp., Bacillus subtillus, Escherichia coli and Klebsiella pneumonia. Additionally, the compounds were tested for antifungici

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16

Sychyeva, Ye S., and M. S. Mukanova. "SYNTHESIS AND CHEMICAL MODIFICATION OF NEW HYDROXYBEZALDEHYDE DERIVATIVES." Chemical Journal of Kazakhstan, no. 3 (September 15, 2023): 127–36. http://dx.doi.org/10.51580/2023-3.2710-1185.34.

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A high pharmacological ability of aromatic benzaldehydes makes them important intermediates for the synthesis of medicinal preparations, such as anticancer, bactericidal, antifungal, and herbicidal drugs. The purpose of this work is the synthesis of biologically active compounds, based on 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde and the establishment of the structure of the synthesized compounds. Results and discussion. New carbonodithioates, based on O-aromatic systems have been synthesized by the interaction of 4-hydroxybenzaldehyde and 4-hydroxy-3-methoxybenzaldehyde with c

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17

Hidayat, Rachmat, and Patricia Wulandari. "Safety Assessment of Combination of Tinospora crispa Extract, Andrographis paniculata, Cinamomum burmanii, Syzygium polyanthum dan Momordica charantia in Hepar and Renal Function." Eureka Herba Indonesia 2, no. 1 (2021): 63–67. http://dx.doi.org/10.37275/ehi.v2i1.13.

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Tinospora crispa, Andrographis paniculata, Cinamomum burmanii, Syzygiumpolyanthum and Momordica charantia contain phenolics and flavonoidswhich are rich in benefits. Phenolic compounds are compounds that have anaromatic ring with one or more hydroxy groups, compounds derived fromplants that have the same characteristics, namely aromatic rings containingone or more hydroxyl groups. Herbal plants, which are rich in phenoliccompounds, have the efficacy, among others, as antioxidants, anti-inflammatory, antimicrobial, anti-fungal and prevents tumor growth. Theacute toxicity test is a procedure des

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18

Talekar, P. R. "Synthesis and Biological Actisvity of Hydroxy Chalcone Their Pyrazole and Isoxazole Derivatives." International Journal of Advance and Applied Research 5, no. 23 (2024): 176–78. https://doi.org/10.5281/zenodo.13622043.

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Abstract: The Heterocyclic compounds and its derivative have wide scope in chemistry and its Shows different Biological Activities due to this intention researcher attract to work. The Chalcone Structure contain two aromatic ring linked by an aliphatic three carbon chain having alpha beta unsaturated ketone with reactive ethylenic group.in claisen-schimdt condensation equimolar quantities of aromatic aldehyde (without alpha hydrogen) and aromatic ketone (with active –CH group) React in the presence of Condensing reagent.in the present work  3-Hydroxy benzaldehyde react with 1,4

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19

CHAPURKIN, V. V., and S. V. CHAPURKIN. "ON THE INTERACTION OF FLUOROCARBONYL COMPOUNDS WITH HYDROGEN PEROXIDE." IZVESTIA VOLGOGRAD STATE TECHNICAL UNIVERSITY, no. 12(295) (December 2024): 10–14. https://doi.org/10.35211/1990-5297-2024-12-295-10-14.

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The interaction of aliphatic and aromatic fluorocarbonyl compounds with hydrogen peroxide leads to the formation of 1-hydroxy-1-hydroperoxides, the hydrocarbon analogues of which are generally unstable. The possibility of their purification and further transformations is shown.

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20

HAMDI, Naceur. "Synthesis, characterization, antibacterial, antioxidant and anti-inflammatory activities of new 4-Aryl-2-amino-6-(4-hydroxy coumarin-3-yl) pyridine-3-carbonitriles derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 11, no. 1 (2016): 3355–63. http://dx.doi.org/10.24297/jac.v11i1.2224.

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This study aimed for the synthesis of 4-Aryl-2-amino-6-(4-hydroxy coumarin-3-yl) pyridine-3-carbonitriles 4 suitable for use as antibacterial, anti-oxidant and anti-inflammatory activities via a versatile, readily accessible 3-((2E)-3(aryl)prop-2-enoyl)-2H-chromen-2-one 3 which were prepared by refluxing 3-acetyl-4-hydroxy coumarin with aromatic aldehydes in chloroform in the presence of a catalytic amount of piperidine. Then the direct reaction of the obtained chalcones 3 with malonitrile in the presence of ammonium acetate in one step gave products 5 .The structures of the new compounds 3-4

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21

Thiruvasagam, P. "Synthesis and characterization of new aromatic hydroxy acid compounds." Bulletin of the Chemical Society of Ethiopia 32, no. 3 (2018): 523. http://dx.doi.org/10.4314/bcse.v32i3.11.

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22

Muriqi, Arbresha, Maarit Karppinen, and Michael Nolan. "Role of terminal groups in aromatic molecules on the growth of Al₂O₃-based hybrid materials." Dalton Transactions 50, no. 47 (2021): 17583–93. http://dx.doi.org/10.1039/d1dt03195c.

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First principles investigation of the molecular mechanism of Al2O3-based hybrid materials grown with homo- or hetero-bifunctional aromatic compounds with hydroxy (OH) and/or amino (NH2) terminal groups.

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23

Corrêa, Gabriela A., Susana L. H. Rebelo, and Baltazar de Castro. "Green Aromatic Epoxidation with an Iron Porphyrin Catalyst for One-Pot Functionalization of Renewable Xylene, Quinoline, and Acridine." Molecules 28, no. 9 (2023): 3940. http://dx.doi.org/10.3390/molecules28093940.

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Sustainable functionalization of renewable aromatics is a key step to supply our present needs for specialty chemicals and pursuing the transition to a circular, fossil-free economy. In the present work, three typically stable aromatic compounds, representative of products abundantly obtainable from biomass or recycling processes, were functionalized in one-pot oxidation reactions at room temperature, using H2O2 as a green oxidant and ethanol as a green solvent in the presence of a highly electron withdrawing iron porphyrin catalyst. The results show unusual initial epoxidation of the aromatic

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24

Fu, Yin Xuan, Hai Bin Zhu, Yan Zhi Sun, Yong Mei Chen, and Ping Yu Wan. "Pyrolysis Products of Lignin at Different Temperature Detected by Py-GC-MS." Advanced Materials Research 663 (February 2013): 392–96. http://dx.doi.org/10.4028/www.scientific.net/amr.663.392.

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Pyrolyzation of lignin to aromatic compounds with small molecule weight is one of the ways to efficient utilization of lignin resource. Basing on the data of thermogravimetric scanning curve (TG-DTG) and pyrolysis-gas chromatography -mass spectrometry (Py-GC-MS), the change in the distribution of pyrolysis products at different temperature was analyzed. The results showed that lignin could produce a large number of aromatic compounds having hydroxy or methoxy groups under the conditions of anaerobic and 250-450°C, but it was not benefit to obtain useful organic compounds when pyrolyzed at elev

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25

Krauss, AS, and WC Taylor. "Intramolecular Oxidative Coupling of Aromatic Compounds. III. Monophenolic Substrates." Australian Journal of Chemistry 45, no. 5 (1992): 925. http://dx.doi.org/10.1071/ch9920925.

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The synthesis of (2RS,3SR)-4-(4-hydroxy-3,5-dimethoxyphenyl)-2,3-dimethyl-1-(3,4,5-trimethoxypheny1)butan-1-one (9) is described. Monophenolic oxidative coupling of (9) did not give any useful result. Oxidation of the derived acetoxy compound (18) by chemical and electrochemical methods gave aryltetralin derivatives through aryl-benzyl coupling.

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26

Krečmerová, Marcela, Antonín Holý, and Milena Masojídková. "Pyrimidine Acyclic Nucleotide Analogues with Aromatic Substituents in C-5 Position." Collection of Czechoslovak Chemical Communications 72, no. 7 (2007): 927–51. http://dx.doi.org/10.1135/cccc20070927.

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NH2-protected 5-phenylcytosine and its derivatives 2a-2d were treated with (2S)-2-[(trityloxy)methyl]oxirane (3) followed by etherification with diisopropyl [(tosyloxy)methyl]phosphonate (5) in the presence of sodium hydride. The intermediary phosphonate esters 6 were debenzoylated and subsequently transformed to free phosphonic acids, i.e. (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]-5-phenylcytosine (5-phenyl-HPMPC) derivatives (8a-8d) by the action of bromotrimethylsilane and subsequent hydrolysis. Deamination of these compounds with 3-methylbutyl nitrite afforded corresponding (S)-1-[3-hyd

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27

Čačić, Milan, and Maja Molnar. "Design, Synthesis and Characterization of Some Novel 3-Coumarinyl- 5-aryliden-1,3-thiazolidine-2,4-diones and Their Antioxidant Activity." Zeitschrift für Naturforschung B 66, no. 2 (2011): 177–83. http://dx.doi.org/10.1515/znb-2011-0210.

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In our effort to obtain biologically active compounds, new 3,5-disubstituted 1,3-thiazolidine-2,4- diones (5a - r) were synthesized. A series of 5-arylmethylidene-1,3-thiazolidine-2,4-diones (3a - r) were prepared by Knoevenagel reaction from 1,3-thiazolidine-2,4-dione (2) and appropriate aromatic aldehydes. Condensation of 3a - r with 7-hydroxy-4-bromomethyl-2-oxo-2H-chromene (1) afforded novel 3-(7-hydroxy-2-oxo-2H-chromen-4-ylmethyl)-5-arylidene-1,3-thiazolidine-2,4-diones 5a - r. Compounds 3a - r and 5a - r were evaluated for their antioxidant activity (DPPH free radical scavenging activit

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28

Zhang, Yong-Kang, and De-Kang Shen. "Notizen: Synthesis of Novel Hydroxy-Substituted Aromatic Aminoxyl Esters and their Azo Derivatives." Zeitschrift für Naturforschung B 48, no. 6 (1993): 849–51. http://dx.doi.org/10.1515/znb-1993-0622.

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Transesterification or acylation method has been used for the preparation of three novel hydroxy-substituted aromatic aminoxyl esters 4, 5, and 8 from which three new spin-labelled azo compounds 10,13, and 14 have been synthesized.

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29

Kostopoulou, Ioanna, Andromachi Tzani, Nestor-Ioannis Polyzos, et al. "Exploring the 2′-Hydroxy-Chalcone Framework for the Development of Dual Antioxidant and Soybean Lipoxygenase Inhibitory Agents." Molecules 26, no. 9 (2021): 2777. http://dx.doi.org/10.3390/molecules26092777.

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2′-hydroxy-chalcones are naturally occurring compounds with a wide array of bioactivity. In an effort to delineate the structural features that favor antioxidant and lipoxygenase (LOX) inhibitory activity, the design, synthesis, and bioactivity profile of a series of 2′-hydroxy-chalcones bearing diverse substituents on rings A and B, are presented. Among all the synthesized derivatives, chalcone 4b, bearing two hydroxyl substituents on ring B, was found to possess the best combined activity (82.4% DPPH radical scavenging ability, 82.3% inhibition of lipid peroxidation, and satisfactory LOX inh

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30

Alka, Pradhan, and Kumar Vishwakarma Sanjay. "Synthesis of quinolone derivatives and their molecular docking for antiepileptic activity." Chemistry International 6, no. 4 (2020): 224–31. https://doi.org/10.5281/zenodo.3700632.

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Compounds having quinolone moiety are associated with wonderful biological activities. In the present study, we synthesized Schiff bases of 7-hydroxy-3-methyl-2-quinolone as well 7-hydroxy-3-methyl-4-quinolone by refluxing them with substituted aromatic carbonyl compounds. The final test compounds were purified and characterized by IR, 1HNMR and Mass Spectral studies. M.P. of these compounds was confirmed by open capillary method instrument chemline cl 725.Docking study of quinolone derivatives was performed on the three high resolution crystal structures of hCA enzyme using Biopredicta module

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31

Ndi, Chi P., Susan J. Semple, and Hans J. Griesser. "Instability of Antibacterial Serrulatane Compounds from the Australian Plant Species Eremophila duttonii." Australian Journal of Chemistry 65, no. 1 (2012): 20. http://dx.doi.org/10.1071/ch11354.

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Hydrophilically substituted diterpenes of the structural class of serrulatanes have attracted attention as novel antibacterial compounds that are effective even against multidrug-resistant Staphylococcus aureus, a key bacterium involved in human infections. The mechanism of action has, however, not been established yet. Available data on structure–activity relationships suggest that the aromatic hydroxy group is essential for activity, and the strongest activity has been found for naphthyl compounds. In this context, it is reported that two highly active serrulatanes isolated from leaf resin o

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Anusuya V, Anusuya V., Muruganantham N. Muruganantham N, Anitha P. Anitha P, and Mahesh S. Mahesh S. "Synthesis of some Schiff base Derivatives using One pot Grinding Method and Its Biological activities." Oriental Journal Of Chemistry 38, no. 6 (2022): 1525–31. http://dx.doi.org/10.13005/ojc/380626.

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In this present study, we reported the synthesis of some Schiff base derivatives by one pot grinding method from 2-hydroxy benzohydrazide and Aromatic aldehydes. NMR and IR spectroscopy were used to characterize the synthesized compounds. The antioxidant, antidiabetic and anti-inflammatory properties of the Schiff base derivatives 3(a-j) were studied. Regarding standards, all the compounds demonstrated good biological activity.

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G. N. Kyadare, Vivekanand B. Jadhav, and Shivaji B. Patwari. "Imidazolium bromo chromate: A new and efficient reagent for bromination of hydroxy aromatic compounds." International Journal of Frontiers in Chemistry and Pharmacy Research 4, no. 1 (2024): 016–19. http://dx.doi.org/10.53294/ijfcpr.2024.4.1.0056.

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A new Cr (VI) oxidizing agent Imidazolium Bromo chromate (IBC) has been used as an efficient and selective nuclear brominating agent for aromatic hydroxyl acetophenones, aldehyde, phenols as well as a brominating agent for unsaturated aromatic compounds. IBC has been found to be an efficient solid reagent that can be easily prepared in good yield.

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34

Kishimoto, T., J. F. Kadla, H. m. Chang, and H. Jameel. "The Reactions of Lignin Model Compounds with Hydrogen Peroxide at Low pH." Holzforschung 57, no. 1 (2003): 52–88. http://dx.doi.org/10.1515/hf.2003.008.

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Summary In peroxymonosulfuric acid bleaching, the presence of hydrogen peroxide is dependent on the reaction conditions and the conversion ratios used to generate the peroxy acid. Substantial amounts of hydrogen peroxide may be present in the reaction system under certain conditions. An understanding of the reactions of hydrogen peroxide under these conditions would be beneficial. Therefore, several simple lignin model compounds were reacted with acidic hydrogen peroxide, pH 1-3, at 70°C. In all cases the phenolic lignin model compounds reacted much faster than their non-phenolic counterparts.

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35

Amanuddin, Amanuddin, Hanggara Arifian, Agung Rahmadani, and Rolan Rusli. "Sintesis 2’-Hidroksi-5’-Kloro-3,5-Dimetoksi-4-Hidroksikalkon." Proceeding of Mulawarman Pharmaceuticals Conferences 11 (February 28, 2020): 50–53. http://dx.doi.org/10.25026/mpc.v11i1.393.

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Chalcone are compounds that have 2 aromatic rings connected by 3 carbon atoms which are an ?, ? unsaturated carbonyl system that have various biological activities. 2'-hydroxy-5'-chloro-3,5-dimethoxy-4-hydroxicalcone was synthesized from 2'-hydroxy-5'-chloro acetophenone and syringaldehyde using a NaOH catalyst. This compound was purified using Column Chromatography by isocratic method using n-hexane:ethyl acetate (15:1) as eluent. This compound has a Rf 0.75 and 2.7% of yield.

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36

B., SUCHARITA REDDY, and DARBARWAR MALLESHWAR. "Synthesis and Physiological Activity of 2H-[1]-Benzothiopyrano[3,4-e ](1 ,3] oxazine-5-ones." Journal of Indian Chemical Society Vol. 63, Mar 1986 (1986): 323–25. https://doi.org/10.5281/zenodo.6254032.

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Department of Chemistry, Osmania University, Hyderabad-500 007 <em>Manuscript received 5 August 1985, accepted 24 December 1985</em> Fourteen benzothiopyranooxazine-5-ones have been synthesised by the condensation of 4-hydroxy-t thiocoumarin and 6 chloro-4-hydroxy-1-thiocoumarin with different Schiff bases (derived from aromatic aldehydes and aniline) in acetic acid medium. The possible reaction mechanism has been advanced. Analytical, spectral and physio- logical properties of the compounds have been evaluated.

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37

Sroka, Zbigniew. "Antioxidative and Antiradical Properties of Plant Phenolics." Zeitschrift für Naturforschung C 60, no. 11-12 (2005): 833–43. http://dx.doi.org/10.1515/znc-2005-11-1204.

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The plant phenolic compounds such as flavonoids, tannins and phenolic acids appeared to be strong antiradical and antioxidant compounds. The number of hydroxy groups and the presence of a 2,3-double bond and orthodiphenolic structure enhance antiradical and antioxidative activity of flavonoids. The glycosylation, blocking the 3-OH group in C-ring, lack of a hydroxy group or the presence of only a methoxy group in B-ring have a decreasing effect on antiradical or antioxidative activity of these compounds. Tannins show strong antioxidative properties. Some tannins in red wine or gallate esters w

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38

Pawar, P. Y., P. M. Gaikwad, and P. H. Balani. "Microwave Assisted Synthesis of N-Substituted-7-hydroxy-4-methyl-2-oxoquinolines as Anticonvulsant Agents." E-Journal of Chemistry 8, no. 2 (2011): 945–51. http://dx.doi.org/10.1155/2011/121476.

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The reaction of resorcinol with ethylacetoacetate yielded the 7-hydroxy-4-methyl coumarin (1), which on treatment with benzidine gives 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2). 1-{4ʹ-[(Substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinolin-2-one (3a-j) were obtained by reacting 1-(4ʹ-amino-biphenyl-4-yl)-7-hydroxy-4-methyl-1H-quinolin-2-one (2) with different substituted aromatic aldehydes in presence of glacial acetic acid by microwave irradiation. The compound 1-{4ɴ-[(substituted benzylidene)-amino]-biphenyl-4-yl}-7-hydroxy-4-methyl-1H-quinol

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39

Kazantseva, M. I., N. N. Kasimova, and V. L. Gein. "Synthesis of 5-Aryl-1-[2-(1H-indol-3-yl)ethyl]- 4-(hydroxy-4-methylphenylmethylene)pyrrolidine-2,3-diones by Reaction of Tryptamine with 4-Methylbenzoyltartaric Acid Methyl Ester and Aromatic Aldehydes." Журнал общей химии 94, no. 3 (2024): 350–57. http://dx.doi.org/10.31857/s0044460x24030041.

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Short heating of a mixture of tryptamine, aromatic aldehyde and 4-methylbenzoylpyruvic acid methyl ester followed by keeping for 24 h at room temperature leads to the formation of 5-aryl-1-[2-(1H-indol-3-yl)ethyl]-4-(hydroxy-p-tolylmethylene)pyrrolidine-2,3-diones. Structure of the obtained compounds was confirmed by IR and 1H NMR spectroscopy methods. Antimicrobial activity of the obtained compounds was investigated.

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40

Naganagowda, Gadada, Reinout Meijboom, and Amorn Petsom. "Synthesis and Antimicrobial Activity of New Schiff Base Compounds Containing 2-Hydroxy-4-pentadecylbenzaldehyde Moiety." Advances in Chemistry 2014 (July 21, 2014): 1–9. http://dx.doi.org/10.1155/2014/921857.

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Various novel Schiff base compounds have been synthesized by reaction of 2-hydroxy-4-pentadecylbenzaldehyde with substituted benzothiophene-2-carboxylic acid hydrazide and different substituted aromatic or heterocyclic amines in the presence of acetic acid in ethanol. The structures of all these compounds were confirmed by elemental analysis, IR, 1H-NMR, 13C-NMR, and mass spectral data and have been screened for antibacterial and antifungal activity.

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41

Ashok, Dongamanti, Rangu Kavitha, Srinivas Gundu, and Rao Hanumantha. "Microwave-assisted synthesis of new pyrazole derivatives bearing 1,2,3-triazole scaffold as potential antimicrobial agents." Journal of the Serbian Chemical Society 82, no. 4 (2017): 357–66. http://dx.doi.org/10.2298/jsc160205016a.

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A new series of (E)-3-(3-(4-substituted phenyl)-1-phenyl-1H-pyrazol- 4-yl)-1-(2-hydroxy-4-((1-aryl-1H-1-2,3-triazol-4-yl)methoxy)phenyl)- prop-2-en-1-one derivatives was synthesized. The synthesis of the title compounds involved the 1,3-dipolar Cu(I)-catalyzed alkyne?azide cycloaddition (CuAAC) reaction of (E)-3-(3-(4-substituted phenyl)-1-phenyl-1H-pyrazol-4- -yl)-1-(2-hydroxy-4-(prop-2-yn-1-yloxy)phenyl)prop-2-en-1-ones with aromatic azides. The structures were confirmed by NMR, FT-IR, mass and elemental analysis. All the synthesized compounds (6a?j) were evaluated for their antimicrobial ac

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42

Gatphoh, Banylla Felicity Dkhar, B. C. Revanasiddappa, M. Vijay Kumar, and Hemanth Kumar. "SYNTHESIS, ANTI-ARTHRITIC AND ANTIOXIDANT ACTIVITIES OF NOVEL 1,3,4-OXADIAZOLE DERIVATIVES." INDIAN DRUGS 55, no. 12 (2018): 18–23. http://dx.doi.org/10.53879/id.55.12.11512.

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A series of novel 2,5-disubstituted-1,3,4-oxadiazoles (2a-j) were synthesized by the reaction of 4-hydroxy benzhydrazide (1) and aromatic aldehydes (2) in the presence of small amounts of ferric chloride in methanol as solvent medium. The synthesized compounds were characterized by various spectrochemical methods including 1H-NMR, IR and MS spectroscopy. The newly synthesized compounds were evaluated for In vitro antioxidant and anti-arthritic activities. Some of the synthesized compounds showed moderate antioxidant and antiarthritic activities.

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43

Neng, N. R., та J. M. F. Nogueira. "Monitoring trace levels of hydroxy aromatic compounds in urine matrices by bar adsorptive microextraction (BAμE)". Analytical Methods 9, № 36 (2017): 5260–65. http://dx.doi.org/10.1039/c7ay01410d.

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In this study, the enhancement for trace analysis of hydroxy aromatic compounds (HACs), such as phenol, hydroquinone, catechol and resorcinol, in urine matrices is proposed using bar adsorptive microextraction combined with micro-liquid desorption followed by high-performance liquid chromatography with diode array detection (BAμE-μLD/HPLC-DAD).

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44

Gatphoh, Banylla Felicity Dkhar, Natasha Naval Aggarwal, Merugumolu Vijay Kumar, and Bistuvalli Chandrashekharappa Revanasiddappa. "Synthesis, in silico Studies, and Anticonvulsant Activity of 1,3,4-Oxadiazole Derivatives." Trends in Sciences 18, no. 23 (2021): 701. http://dx.doi.org/10.48048/tis.2021.701.

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The title compounds 1,3,4-oxadiazole derivatives (C1-5) were synthesized by the cyclization of 4-hydroxy benzhydrazide (1) with various substituted aromatic aldehydes (2) in the presence of ceric ammonium nitrate. The structures of the newly synthesized compounds were established based on FT-IR, 1H-NMR, and Mass spectral data. In silico analysis was carried out using the Schrodinger 2018-3 suite device Maestro and docked to the binding site of the Human GABAA receptor (PDB ID:4COF). The toxicity of the compounds was predicted using the LAZAR (Lazy structure-activity relationship) program. The

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Hashmi, Imran Ali, Wolfgang Frey, Ivo C. Ivanovc, and Willi Kantlehner. "One-pot, Three-component Synthesis of 7H-[1,3,4]Thiadiazolo[ 3,2-a]pyridines from 2-Phenacyl-[1,3,4]thiadiazole Derivatives and Arylmethylene-cyanoacetic Acid Derivatives." Zeitschrift für Naturforschung B 62, no. 10 (2007): 1298–304. http://dx.doi.org/10.1515/znb-2007-1011.

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Generally, arylmethylene-cyanoacetic acid derivatives react with enols and aromatic or heteroaromatic hydroxy compounds to afford 2-amino-4H-pyran derivatives of type 6. In contrast, a ring closure with the nitrogen atom of the thiadiazole ring occurs when 2-phenacyl-1,3,4-thiadiazoles (1a - d) act on derivatives of arylmethylene-cyanoacetic acid giving rise to the formation of 7H- [1,3,4]thiazolo[3,2-a]pyridine derivatives 5a - r. The same products are obtained if 2-phenacyl-1,3,4- thiadiazoles react with aromatic or heteroaromatic aldehydes and cyanoacetic acid derivatives. The constitution

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46

Kirkova, Desislava, Yordan Stremski, Maria Bachvarova, et al. "New Benzothiazole–Monoterpenoid Hybrids as Multifunctional Molecules with Potential Applications in Cosmetics." Molecules 30, no. 3 (2025): 636. https://doi.org/10.3390/molecules30030636.

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The Thymus vulgaris and Origanum vulgare essential oils (contained thymol and carvacrol in a range of 35–80%) are used in various products in the fields of medicine, cosmetics, and foods. Molecular hybridization between benzothiazole (BT) and phenolic monoterpenoids is a promising method for the development of biologically active compounds. New benzothiazole–monoterpenoid hybrids were synthesized through a regioselective α-amidoalkylation reaction of thymol and carvacrol with high yields (70–96%). This approach is both simple and cost-effective, employing easily accessible and inexpensive reag

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MURAMATSU, YASUJI, KENTARO KURAMOTO, ERIC M. GULLIKSON, and RUPERT C. C. PERERA. "SOFT X-RAY ABSORPTION SPECTRA IN THE 0 K REGION OF MICROPOROUS CARBON AND SOME REFERENCE AROMATIC COMPOUNDS." Surface Review and Letters 09, no. 01 (2002): 267–70. http://dx.doi.org/10.1142/s0218625x02002178.

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To analyze the oxidation states of the graphitic surface of microporous carbon, soft X-ray absorption spectra in the 0 K region have been obtained for microporous carbon and various aromatic compounds. The aromatic molecules studied are substituted with one or more of the following oxygenated functional groups: hydroxy (–OH), carboxy (–COOH), carbonyl (>C=O), formyl (–CH=O), and ether (–O–). From comparison of the soft X-ray absorption spectra of microporous carbon and of reference aromatic compounds, the most probable chemical bonding states of oxygen in microporous carbon are found to be

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48

Jezierska, Aneta, Peter M. Tolstoy, Jarosław J. Panek, and Aleksander Filarowski. "Intramolecular Hydrogen Bonds in Selected Aromatic Compounds: Recent Developments." Catalysts 9, no. 11 (2019): 909. http://dx.doi.org/10.3390/catal9110909.

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A review of intramolecular hydrogen bonding in ortho-hydroxyaryl Schiff bases, ortho-hydroxyaryl Mannich bases, dipyrrins, ortho-hydroxyaryl ketones, ortho-hydroxyaryl amides, and 4-Bora-3a,4a-diaza-s-indacene (BODIPY) dyes with tautomeric sensors as substituents is presented in this paper. Ortho-hydroxy Schiff and Mannich base derivatives are known as model molecules for analysing the properties of intramolecular hydrogen bonding. The compounds under discussion possess physicochemical features modulated by the presence of strong intramolecular hydrogen bonds. The equilibrium between intra- an

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Duc, Dau Xuan, and Vo Cong Dung. "Recent Progress in the Synthesis of Isoxazoles." Current Organic Chemistry 25, no. 24 (2021): 2938–89. http://dx.doi.org/10.2174/1385272825666211118104213.

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Isoxazole derivatives are aromatic five-membered ring heterocyclic compounds with one oxygen atom and one nitrogen atom at adjacent positions. These compounds have a broad spectrum of applications in medicinal chemistry, such as antimicrobial, anticancer, antitumor, antitubercular, analgesic, anti-inflammatory, antidepressant, and anticonvulsant activities and some of them are well-known drugs for the treatment of various diseases in the market. The use of this class of compounds in agriculture as herbicides, insecticides have been widely reported. In organic materials, these compounds have be

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50

Gein, V. L., D. G. Dianova, O. O. Senokosova, N. V. Nosova, E. A. Buldakova, and I. G. Mokrushin. "Three-Component Synthesis of 5-Aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrroline-2-ones." Журнал общей химии 94, no. 3 (2024): 342–49. http://dx.doi.org/10.31857/s0044460x24030039.

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A series of new 5-aryl(hetaryl)-4-aroyl-1-isobutyl-3-hydroxy-3-pyrrolin-2-ones were synthesized by reacting methyl esters of aroylpyruvic acids with aromatic (heterocyclic) aldehydes and isobutylamine in dioxane. Antimicrobial activity of the obtained compounds was studied in vitro against Staphylococcus aureus, Escherichia coli and Candida albicans strains.

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