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McGreevy, Jeanette Sue. "No school business official left behind School business officials, superintendents, and role theory--Association of school business officials (ASBO) international professional standards and job proficiency /." [Ames, Iowa : Iowa State University], 2006.
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Svensson, Carl-Johan, and Jesper Åkerstedt. "Prognosprocessen : En fallstudie hos Asko Cylinda AB." Thesis, University of Skövde, School of Technology and Society, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-119.
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<p>Balansering av tillgång och efterfrågan har alltid varit ett aktuellt ämne och för att klara av denna balansering krävs information om kommande efterfrågan. Denna information måste ligga så långt fram i tiden som det tar för att med säkerhet få hem exempelvis material. För att lyckas med detta använder sig företag i olika utsträckning av uppskattad framtida efterfrågan, så kallade prognoser. Prognoser kan definieras som systematiska metoder för att förutsäga framtida händelser.</p><p>Problemet är att oavsett hur prognoser görs stämmer det prognostiserade värdet nästan aldrig överens med det verkliga utfallet. Många företag vet att deras prognoser inte är exakta utan att veta vad de ska göra åt saken. Många gånger ignorerar de bara problemet och hoppas att det ska lösa sig självt. För att kunna förbättra sina prognoser bör därför dokumentation och uppföljning ske av det arbete som görs. Med hjälp av uppföljning kan prognosfel beräknas, ett prognosfel är avvikelsen mellan det prognostiserade värdet och det verkliga utfallet. I de fall då prognosfelen är små kan företag genom dokumentation identifiera vad som urskilde dessa perioder från de med högre prognosfel.</p><p>Författarna har i denna uppsats försökt beskriva hur företag kan uppnå en förbättrad prognosprocess med en lägre prognosavvikelse. Uppsatsen syftar också till att väcka intresset för samarbete över företagsgränser. Collaborative forecasting är en av metoderna som författarna har använt sig av för att överkomma problemen med traditionell prognostisering och som samtidigt är i linje med supply chain management. Denna metod samlar ihop och sammanställer information från både interna och externa källor för att sedan sammanställa en prognos som stöds av hela organisationen.</p><p>Uppsatsen är en fallstudie hos vitvaruföretaget Asko Cylinda AB. För att få ytterligare idéer om hur prognosprocessen kan se ut i praktiken har författarna också tittat på prognosprocessen hos Volvo Penta AB. Båda företagens prognosprocesser har sedan analyserats och jämförts med hjälp av teori från litteratur och artiklar. Genom denna analys har författarna kommit fram till förslag på arbetssätt som Asko Cylinda AB och företag med liknande företagsmiljö kan använda sig av för att förbättra sin prognosprocess.</p><p>Analyskapitlet är uppbyggt enligt tre scenarier, en nulägesbeskrivning, ett förslag på en enkel prognosprocess och ett förslag på en mer avancerad prognosprocess. I analysen har olika mätetal används för att åskådliggöra hur prognosavvikelsen varierar då till exempel olika prognosberäkningsmetoder används.</p><p>Utifrån scenarierna som analyserats har författarna kommit fram till att det finns många fördelar med Asko Cylinda AB:s nuvarande arbetssätt och att flera av dessa stöds av teorin. En fördel med en enklare prognosprocess är att den allokerar betydligt mindre resurser än vad som görs i dagsläget. Detta är enligt författarna inte tillräckligt skäl att använda sig av den enkla varianten då framtiden går mot mer samarbete över företagsgränserna för att gemensamt öka konkurrenskraften. Arbetssättet som analyseras i scenario 3 ses av författarna som det bästa alternativet. Detta scenario har hämtat mycket inspiration från teorierna om collaborative forecasting, vilket bidrar till en process som arbetar mer enligt supply chain management. Även delar från både den nuvarande prognosprocessen och Volvo Penta AB:s prognosprocess har använts för att för att uppnå detta arbetssättsförslag som baserats på både teori och praktik och utformats för att vara slagkraftigt i framtiden.</p>
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Juránek, Oldřich. "Expanze ASIO, spol. s.r.o. na Kolumbijský trh." Master's thesis, Vysoké učení technické v Brně. Fakulta podnikatelská, 2011. http://www.nusl.cz/ntk/nusl-223237.
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Final thesis is focused on an entrance into an international market by company ASIO, Ltd. specialized on the field of water-management. The thesis is based on close analysis of Colombian market. The thesis is consisted of theoretical platform, analysis of macro- environments, segmentation of market, analysis of competitiveness, analysis of norms focused on water use and liquid waste and the proposed solution the company entered the Colombian market.
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Štych, Jan. "Vstup firmy ASIO spol. s.r.o. na brazilský trh." Master's thesis, Vysoká škola ekonomická v Praze, 2013. http://www.nusl.cz/ntk/nusl-192531.
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The thesis deals with possibilities of setting up an enterprise in Brazil. Specifically, it is focused on water management and wastewater treatment sector. Apart from political, economic, sociological and technological analysis, the thesis also contains the water management sector analysis, including current trends and opportunities. The main goal of the thesis is to create a suitable base for entrance of the Asio ltd. into brazilian wastewater market and propose an own solution regarding a possible expansion.
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Canales, Alania Edith Pamela, Inga Erika Rossi Dávila, Quelopana Francisco Javier Izquierdo, and Águila Sebastián Rada. "Máquinas expendedoras de artÍculos de aseo personal - Vendiclean." Bachelor's thesis, Universidad Peruana de Ciencias Aplicadas (UPC), 2019. http://hdl.handle.net/10757/626224.
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El presente trabajo de investigación consta en un modelo de negocio innovador y viable para el mercado, consiste en implementar máquinas expendedoras de productos de aseo personal para brindarles a los consumidores alternativas al momento de olvidarse sus utensilios; es por ello que los puntos estratégicos de ventas serán las universidades y empresas privadas. Cabe indicar, que el medio de conexión para llegar a los consumidores es a través las redes sociales; asimismo se elaborarán brochures informativos que serán distribuidos en las oficinas corporativas y folletos para las universidades en los distritos ubicados en las zonas 1, 2, 3, 4, 6 y 8 de Lima Metropolitana donde se encuentran los consumidores potenciales y así nace la idea de negocio Vendiclean.
La empresa para obtener los ingresos económicos ofrecerá artículos de aseo personal, tales como: Toallas húmedas, cepillos de dientes, pasta dental, hilo dental y desodorante. Esto permitirá que los jóvenes que estudian o trabajan tengan la seguridad que, si olvidan algún producto de aseo, puedan contar con productos de primera necesidad para atender urgencias personales a través de nuestras máquinas expendedoras la cual contará con los productos de aseo necesarios y les facilitará la vida de forma inmediata, debido a que el medio de pago será en efectivo y con POS. Vendiclean ofrecerá a las empresas y universidades contar con un ingreso adicional si se asocian a nuestro servicio con la finalidad de atraer consumidores hacia Vendiclean donde ahorraremos el tiempo de adquisición de compra por parte del consumidor.<br>The present research work consists of an innovative and viable business model for the market, consists of implementing vending machines for personal hygiene products to provide consumers with alternatives when forgetting their utensils; that is why the strategic sales points will be universities and private companies. It should be noted that the means of connection to reach consumers is through social networks; Likewise, information brochures will be developed and distributed to corporate offices and brochures for universities in the districts located in zones 1, 2, 3, 4, 6 and 8 of Metropolitan Lima where potential consumers are located and thus the idea of Vendiclean business.
The company to obtain the economic income will offer personal hygiene items, such as: Wet towels, toothbrushes, toothpaste, dental floss and deodorant. This will allow young people who study or work have the security that, if they forget to cleaning products, they will count on products of first necessity to attend to personal urgencies through our vending machines which will have the necessary cleaning products and will facilitate them life immediately, because the means of payment will be in cash and with POS.
Vendiclean will offer companies and universities with additional income that will be associated with our service in order to attract consumers.<br>Trabajo de investigación
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Badilla, Torrico Ximena Patricia, and García Alejandro Cuevas. "Hoteliza." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/137044.
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Tesis para optar al grado de Magíster en Administración<br>Ximena Patricia Badilla Torrico [Parte I Análisis estratégico y de mercado ], Alejandro Cuevas García [Parte II Análisis organizativo-financiero]<br>Autor no envía autorización para acceso a texto completo de su documento. (Parte I)<br>El litoral central de Chile y en especial la zona comprendida en la primera, segunda, y tercera línea de playa
entre Valparaíso, Viña, Reñaca y Con Con ha experimentado durante los últimos 10 años un explosivo
desarrollo inmobiliario. Muchas de estas viviendas son adquiridas como segunda inversión o lugar de
descanso temporal. Claramente bajo esta perspectiva o espacio de descanso, se complica al considerar el
tiempo que debe asignarse a limpieza de la propiedad.
La pregunta es ¿existe oferta para cubrir la demanda de aseo generada por más de 150 edificios de
departamentos en esta zona? Preliminarmente, creemos que existe una oportunidad cierta de suministrar este
servicio, basándose en un modelo se servicio que no requiere personal doméstico permanente, sino por evento
y personalizado. Considerando la no existencia de una compañía con estas características en la zona, esto se
traduce en la ausencia de competencia directa en el mercado relevante definido para la empresa que se
proyecta, lo que se transforma en un factor clave de éxito que permitirá el cumplimiento de los objetivos
institucionales establecidos en el plan de negocio formulado en este informe.
Este proyecto implica la creación de HOTELIZA; una empresa de servicios de aseo, mantenciones menores
y venta de paquetes de productos para cubrir necesidades básicas a propiedades en la zona y cuya visión y
misión se asocian a facilitar la vida a estos propietarios a través de un contrato simple de prestación de
servicios por un período no inferior a tres meses con pago por internet facilitando y disminuyendo los costos
de transacción asociados al contrato que se establezca.
Con HOTELIZA se pretende crear valor para los clientes a través de la maximización del tiempo y sus
recursos, pagando por un servicio eficiente y proporcional a sus necesidades; evitado costos fijos (gas,
electricidad, luz, cable, etc) derivados de la mantención de personal permanente. El segmento de clientes
definido y mercado objetivo propuesto para dirigir la estrategia comercial de la empresa recibirá como
beneficio, el contar con un servicio de calidad, personalizado y acorde a estándares de seguridad establecidos
con el mismo cliente, de manera que este tenga la tranquilidad de dejar su hogar en manos de una
organización seria, confiable y segura, que le permitirá mantener en este un ambiente agradable, limpio y
fresco. Los análisis realizados indican que esta industria es atractiva en un 55%, por lo que la posibilidad de operar un negocio con estas características se hace viable, atractivo y rentable, permitiendo recuperar la
inversión en los tres primeros años de operación.
La estrategia de la compañía estará basada en la diferenciación del servicio proporcionado a sus clientes
objetivos. Esta se sustentará en las variables diferenciadoras que se posicionarán en el consumidor final:
Calidad, Seguridad y Personalización. Esta estrategia base permitirá también cumplir con la estrategia de
ventas directa establecida en la estrategia comercial de la empresa para los tres primeros años de operación,
basada en la figura de un “Relacionador para el Hogar”.
La ventaja competitiva de HOTELIZA, será la curva de experiencia que desarrollaremos al ser los primeros
en implementar este servicio en la zona. Si bien la inversión inicial es medianamente relevante, lo importante
será que el funcionamiento operativo de la empresa sea de excelencia para garantizar los flujos del negocio
y cuyos márgenes operacionales esperados podrían estar ya en el 6,2% anual en el segundo año de operación,
para ser positivos a partir de ese año.
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Grahn, Magnus, and Henrik Lainla. "Förbättring av tillgänglighet robotcell för diskmaskinsbehållare samt cylinder-behållarline tvättmaskinscylindrar och behållare." Thesis, University West, Department of Technology, Mathematics and Computer Science, 2004. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-840.
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Brajeux, Marie-Aimée. "ASBOs and the community : towards a new model of liability?" Thesis, Queen Mary, University of London, 2015. http://qmro.qmul.ac.uk/xmlui/handle/123456789/7929.
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his thesis argues that anti-social behaviour orders (ASBOs) are the imperfect expression of a new type of community-based liability which seeks to regulate an individual’s behaviour in the context of his relationship with a particular community. The combination of civil and criminal elements in ASBOs stems from a political will to address responsibility for behaviour which is harmful to a community. Despite the central conceptual role played by the community relationship in ASBOs, legal provisions have failed to define the nature of that relationship, relying on judicial discretion to shape the orders’ application in practice. Judicial interpretation of ASBO legislation confirms the alternative nature of the orders, and the importance of the concept of community in creating a different type of liability. From a theoretical perspective, communitarian principles provide a basis for explaining how the individual/community relationship can justify and shape liability. The figure of a responsible individual constituted by his social interactions forms the premise of this type of liability, and the concept of community in this context is established as a fluid rather than rigid notion, defined as a social group connected by a range of specific interests. A model of community-based liability can be constructed from these principles: interference with a community’s interests can justify the imposition of liability, provided the individual’s behaviour represents a wilful engagement with that particular community. This model of liability provides a useful framework through which to re-examine ASBOs. While the case law broadly adopts the defining elements mentioned above, the use of ASBOs shows examples of misapplications of the principles of a community-based model of liability. Nevertheless, this framework also shows how ASBOs can be seen as a flexible and potentially integrative approach to regulating different types of individual/community relationships, despite the missed opportunities sometimes created by their practical application.
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Svensson, Sofia. "Konstruktion av spoltorn för höj- och sänkbar överkorg till diskmaskin." Thesis, University West, Department of Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-738.
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Möller, David. "Flödessimulering av färdigvarulager." Thesis, University West, Department of Technology, 2002. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-797.
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Fromm, Asko [Verfasser]. "3-D-Printing zementgebundener Formteile. Grundlagen, Entwicklung und Verwendung / Asko Fromm." Kassel : Kassel University Press, 2014. http://d-nb.info/106569217X/34.
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Hynne, Tuva. "Jobbengasjement og overskudd fra jobben hos ansatte ved ASKO Midt-Norge." Thesis, Norges teknisk-naturvitenskapelige universitet, Psykologisk institutt, 2012. http://urn.kb.se/resolve?urn=urn:nbn:no:ntnu:diva-16667.
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Klinikk 5 Bedrifthelsetjeneste har de siste to årene startet opp et nærværsprosjekt i bedriften ASKO Midt-Norge. Formålet med nærværsprosjektet har vært å kartlegge hvilke faktorer som skaper en positiv arbeidshverdag for de ansatte og hvordan disse faktorene kan ivaretaes slik at nærværet økes på en måte som er positiv for alle parter. Masteroppgaven har gått ut på å undersøke jobbengasjement og overskudd fra jobben hos de ansatte i ASKO M-N. Bedriften kan ha mye å hente på en økning i jobbengasjementet hos sine ansatte. Jobbengasjement er vist å øke produktiviteten, ivareta helse, bedre resultater og gi mer fornøyd klientell (Bakker & Demerouti, 2008; Bakker, Schaufeli, Leiter, & Taris, 2008; Salanova, Agut, & Peiró, 2005). Oppgavens problemstillingen er: Hvordan kan jobbengasjement og overskudd fra jobben ivaretas og forbedres hos de ansatte ved ASKO Midt-Norge innenfor rammene av nærværsprosjektet? Indeksene jobbressurser, jobbengasjement, tilrettelegging, nærværspress, overskudd fra jobben og sunne omstillingsprosesser ble målt med et fire sider langt spørreskjema. Alle de ansatte ved ASKO M-N ble bedt om å svare på skjemaet. Data ble deretter analysert i SPSS. Det ble kjørt faktoranalyse, korrelasjonsanalyse og hierarkisk regresjonsanalyse på data. Begrepet nærværsmotivasjon er nytt og foreslåes som et mål på kombinasjonen av nærværspress og tilrettelegging på arbeidsplassen. Kun jobbressurser kunne predikere endringer i jobbengasjement. Både korrelasjonsanalysen og regresjonsanalysen bekreftet hypotesen om at jobbengasjement var den viktigste faktoren i prediksjon av overskudd fra jobben. Konklusjonen er at jobbengasjement og overskudd fra jobben bør ivaretaes og økes hos den ansatte. På den måten vil både bedrift og arbeider kunne oppnå en positiv utvikling i form av lavere sykefravær, økt produktivitet, bedre helse og økt trivsel. Å ivareta og øke jobbengasjement og overskudd fra jobben krever et fokus på jobbressurser og nærværsmotivasjon. Med et slikt fokus forsterkes de faktorene som skaper positiv utvikling og endring hos de ansatte, samtidig som de faktorene som skaper press og slitasje reduseres.
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Turk, Ana. "Warranty claims analysis for household appliances produced by ASKO Appliances AB." Thesis, Linköpings universitet, Statistik, 2013. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-96955.
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The input collected from warranty claims data links customer feedback with product quality. Results from warranty claim analysis can potentially improve product quality, customer relationships and positively affect business. However working on warranty claims data holds many challenges that requires a significant share of time devoted to data cleaning and data processing. The purpose of warranty claims analysis is to get the comprehensive overview of the reliability, costs and quality of household appliances produced by ASKO. While there are different ways to approach this problem, we will focus on non-parametric and semi-parametric methods, by using Kaplan-Meier estimators and Cox proportional hazard model respectively. These kinds of models are time dependent and therefore used for prediction of household appliance reliability. Even though non-parametric models are quite informative they cannot handle additional characteristics about observable product hence the semi-parametric Cox proportional hazard model was proposed. Apart from the reliability analysis, we will also predict warranty costs with probit model and observe inequality in household appliances part failures as a part of quality control analysis. Described methods were selected due to the fact that the warranty claims analysis will be practiced in future by ASKO’s quality department and therefore straight forward methods with very informative results are needed.
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Nies, Silke Marie. "Tryptophanabhängige Synthese von indolhaltigen Pigmenten bei verschiedenen humanpathogenen Asco- und Basidiomyceten." Giessen : VVB Laufersweiler, 2006. http://geb.uni-giessen.de/geb/volltexte/2006/3839/index.html.
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Keyes, Kristen. "Geographic and habitat fidelity in the short-eared owl (Asio flammeus)." Thesis, McGill University, 2011. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=103752.
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Over the past half a century, the Short-eared Owl (Asio flammeus) has experienced a severe population decline across North America. Many aspects of Short-eared Owl natural history are poorly understood, thus hampering the development of effective management plans. The overall goal of this thesis was to help to fill the knowledge gaps that exist, and at the same time provide a foundation for future studies. The specific objectives were three-fold: 1) to investigate Short-eared Owl spatial origins across North America in the context of nomadic, migratory and/or philopatric movements; 2) to develop a practical visual survey protocol aimed at improving monitoring efforts and facilitating assessments of across season landscape-level habitat use; and 3) to describe nest site characteristics, success, and causes of failure. Stable isotope analysis was used to investigate spatial origins of Short-eared Owls, and while exploratory in nature, evidence was provided that the species may exhibit different movement strategies across their North American range. The volunteer visual survey protocol developed here was successful over a trial period, and should become a reliable monitoring scheme to track abundance and distribution through time. Based on the comparison of sites 'used' versus 'available' on two islands on Lake Ontario near Kingston, in eastern Ontario, the Short-eared Owl's use of forest cover during the winter appears to be dependent on seasonal effects. Also, during the breeding season in this geographical area, grazed grassland with scattered trees should be considered important habitat. Short-eared Owls exhibited a tendency for loose nesting aggregations in areas that were predominantly tall grasses, and often on grazed grassland. Fledging success was low and both anthropogenic and natural causes of mortality were identified. The findings of this study will contribute greatly to the current understanding of Short-eared Owl natural history, and the techniques described will be valuable tools for subsequent research and conservation initiatives.<br>Au cours de la dernière moitié du siècle, la population du hibou des marais (Asio flammeus) a subi d'un déclin sévère à travers l'Amérique du Nord. Plusieurs aspects de leur histoire naturelle sont mal compris, entravant ainsi le développement de plans de gestion efficaces. Le but principal de cette thèse était d'essayer de combler le manque de notions à l'égard du hibou des marais tout en assurant une base pour les études ultérieures. Les objectifs spécifiques comportent trois volets: 1) examiner les origines spatiales à travers l'Amérique du Nord en lien avec les déplacements nomades, migratoires et/ou philopatriques; 2) développer un protocole pour les sondages visuels visant à améliorer les efforts de surveillance, et à faciliter l'évaluation de l'utilisation de l'habitat à travers les saisons à l'échelle du paysage; et 3) décrire des sites de nidification, le succès des nids et les causes d'échec de la nidification. L'analyse des isotopes stables était utilisée pour examiner les origines spatiales, et malgré son aspect exploratoire, cette méthode a démontrée que l'espèce pourrait posséder différentes stratégies de déplacement à travers l'Amérique du Nord. Le protocole mis en place pour les sondages visuels accomplis par des bénévoles fût un succès durant la période d'essai, et devrait être une méthode de surveillance sûre pour suivre l'abondance et la distribution de l'espèce à travers le temps. Sur la base d'une comparaison des sites 'utilisés' et 'disponibles' sur deux îles du Lac Ontario près de Kingston dans l'est de l'Ontario, l'importance du couvert forestier durant l'hiver semblent dépendre des effets climatiques saisonniers. Aussi, durant la saison de reproduction dans cette région, le pâturage avec les arbres épars doit être considérés comme l'habitat essentiel. Les hiboux des marais ont démontré une tendance pour les nids faiblement agrégés, dans des régions principalement constitués de hautes herbes et souvent dans les pâturages. Le succès d'envol était faible, et les causes de mortalité naturelles et anthropiques étaient identifiées. Les conclusions de cette étude vont contribuer énormément à la compréhension de l'histoire naturelle du hibou des marais, et les techniques décrites seront des outils de valeur pour la recherche et les efforts de conservation dans l'avenir.
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Williams, Robert Stansell Roslin. "Ecology and population dynamics of the long-eared owl Asio otus." Thesis, University of East Anglia, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.338230.
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Hernández, Palma Pablo. "Plan de Negocios: — Empresa de Aseo Integral para Domicilios y Oficinas." Tesis, Universidad de Chile, 2011. http://repositorio.uchile.cl/handle/2250/108066.
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El siguiente plan de negocio tiene por objetivo, analizar el eventual emprendimiento de una
empresa de aseo para domicilios y pequeñas oficinas, en que las labores de limpieza se
profesionalicen con instrumental y personal capacitado para aquello, el segmento al cual
se enfocará el proyecto es de aquellas viviendas de hogares jóvenes como también del
segmento single, compuesto por solteros y separados, en que el medio de contacto con los
clientes será a través del e-commerce.
Para desarrollar el plan de negocios se evaluará el mercado, la industria, estrategia de
servicios y marketing, la implantación, el modelo de negocio, asuntos legales, la evaluación
financiera y los riesgos. De la investigación y el emprendimiento propuesto, se llegará a
determinar la efectividad de realizar este proyecto, que dado sus riesgos, los resultados
financieros son positivos para iniciar esta empresa.
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Barrera, Paez Natalia, Sánchez Xavier Cifuentes, La Roche Molano Erika De, and Cujar Nicolás Velásquez. "Calidad en las empresas del sector cosmético y aseo en Colombia." Master's thesis, Pontificia Universidad Católica del Perú, 2015. http://hdl.handle.net/20.500.12404/14299.
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Las empresas colombianas han identificado que la calidad es un factor clave para
lograr la competitividad y el éxito en el mercado nacional e internacional. Esta tendencia ha
generado un creciente interés de las empresas por adquirir las certificaciones de un sistema de
gestión de calidad. Para tener una mejor comprensión de los efectos y resultados de la
implementación de un sistema de gestión de calidad al interior de las empresas del Sector
Cosmético y de Aseo en Colombia, se realizó una investigación de tipo cuantitativo,
descriptiva y transeccional. Su objetivo fue identificar si las empresas del Sector Cosmético y
Aseo con Sistema de Gestión de Calidad (SGC) tienen un mayor nivel de calidad comparado
con aquellas que no tiene un SGC.
Para lo anterior, se aplicó un cuestionario de 35 preguntas, según el Modelo de Nueve
Factores del TQM, desarrollado por Jorge Benzaquen de las Casas (2013), a una muestra de
124 empresas del sector cosmético y de aseo en Colombia. Los nueve factores analizados,
que permitieron conocer el nivel de compromiso y estado de implementación de la calidad
fueron: alta gerencia, planeamiento de la calidad, auditoría y evaluación de la calidad, diseño
del producto, gestión de la calidad del proveedor, control y mejoramiento de proceso,
educación y entrenamiento, círculos de calidad y enfoque hacia la satisfacción del cliente.
Como resultado de esta investigación, las empresas que cuentan con un sistema de
gestión de calidad presentan una mayor puntuación en los nueve factores del TQM. Es decir,
que estas empresas tienen mejores sistemas de gerenciamiento, planeación, ejecución y
control de sus procesos, los cuales están enmarcados bajo una óptica de cumplimiento y
gestión de la calidad en todas las etapas productivas, promoviendo un mejoramiento continuo
al interior y al exterior de la organización. Este impacto positivo que genera la implementación de un sistema de gestión de calidad, no solo asegura el cumplimiento de los
principios básicos de calidad, sino que además permite un gerenciamiento más estratégico,
con metas claras y definidas y una visión de éxito a largo plazo. De igual manera permite una
incorporación de la calidad en todos los procesos de la compañía, incluyendo el desarrollo y
diseño de nuevos productos de acuerdo a las necesidades del mercado, así como el
mantenimiento de los proveedores como aliados estratégicos. También garantiza el
compromiso del personal en términos de calidad, lo que permite la creación de oportunidades
de mejora en todos los procesos, haciéndolos cada vez más eficientes, competitivos y
sostenibles.
Estos resultados son una base para que el Gobierno Nacional pueda conocer el estado
de la calidad en las empresas del sector cosmético y de aseo en Colombia y pueda formular
planes de acción para mejorar este estado. Como sugerencia, el Gobierno Nacional, la ANDI,
el Programa de Transformación Productiva (PTP) y el INVIMA, entre otros, deben aumentar
su colaboración y soporte a las empresas del sector cosmético y aseo en Colombia, en cuanto
a la capacitación, implementación, evaluación y certificación de sistemas de gestión de
calidad, para alcanzar la visión del PTP: “en el 2032 Colombia será reconocida como un líder
mundial en producción y exportación de cosméticos”. En el caso de las compañías del sector
cosmético y de aseo en Colombia, se recomienda que inicien lo antes posible la
implementación de un sistema de gestión de calidad, pues esto les permite ser más
productivas, competitivas, y estar preparadas para la globalización.<br>Colombian companies have identified that the quality is a key factor to achieve
competitiveness and success in the national and international market. This trend has
generated an increased interest of the companies to acquire the certifications of the quality
management system. To obtain a better understanding of the effects and results of the
implementation of a quality management system inside the companies of the Cosmetic and
Toiletries Industry in Colombia, a quantitative, descriptive and cross-sectional investigation
was performed. Its objective was to identify if the companies of the Cosmetic and Toiletries
Industry in Colombia with a quality management system (SGC) have a higher quality level
compared with the ones that doesn´t have a quality management system.
Thirty five (35) questions were applied to a sample of 124 companies of the Cosmetic
and Toiletries Industry in Colombia, according to the “Modelo de Nueve Factores del TQM”,
developed by Jorge Benzaquen de las Casas (2013). The nine (9) factors that allow us to
know the level of commitment and the state of the quality implementation were: senior
management, quality planning, audit and evaluation of the quality, product design, quality
management of the vendor, process control and improvement, education and training, quality
circles and focus on customer satisfaction.
As a result of this investigation, the companies that have a quality management
system have a higher score in the nine factors of the TQM. These companies have better
management systems, planning, execution and control of their processes, which are framed
under the compliance and quality management in all the production stages, promoting a
continuous improvement inside and outside the company. This positive impact generated by
the implementation of a quality management system, assure the accomplishment of the basic quality principles and also, allow an strategic management, with clear and defined goals and a
vision of a long term success. Also, it allows incorporating the quality in all the process of the
company, including the development and design of new products according to the market
needs, as well as the management of the suppliers as strategic allies. At the same time, it
guarantees the staff commitment in terms of quality, which allows the creation of
improvement opportunities in all the processes, making them more efficient, competitive and
sustainable.
These results are a base so the Nacional Government can know the quality state of the
companies of the Cosmetic and Toiletries Industry in Colombia and can define action plans to
improve this state. As a suggestion, the National Government, the ANDI, the Programa de
Transformación Productiva (PTP) and the INVIMA, should increase their collaboration and
support to the companies of the Cosmetic and Toiletries Industry in Colombia, in terms of
training, implementation, evaluation and certification of the quality management system, to
be able to achieve the vision of the PTP: “in 2032 Colombia will be recognized as a
worldwide leader in production and exportation of cosmetic products”. In the case of the
companies of the Cosmetic and Toiletries Industry in Colombia, we recommend that they can
initiate as soon as possible with the implementation of a quality management system, because
this will allow them to be more productive, competitive and prepared for the globalization.<br>Tesis
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Quint, Dustin Van Blaricom. "IMPLEMENTATION AND VALIDATION OF THE ζ-f AND ASBM TURBULENCE MODELS". DigitalCommons@CalPoly, 2011. https://digitalcommons.calpoly.edu/theses/636.
Full textAbstract:
The use of Computational Fluid Dynamics (CFD) tools throughout the engineering industry has become standard. Simulations are used during nearly all steps throughout the life cycle of products including design, production, and testing. Due to their wide range of use, industrial CFD codes are becoming more flexible and easier to use. These commercial codes require robustness, reliability, and efficiency. Consequently, linear eddy viscosity models (LEVM) are used to model turbulence for an increasing number of flow types. LEVM such as k-ε and k-ω provide modeling with little loss of computational efficiency and have proven to be robust. The LEVM that are most common in CFD tools, however, are not adequate for accurate prediction of complex flows. This includes flows with high streamline curvature, strong rotation and separation regions. Unfortunately, due to their ease of use in the commercial CFD tools, the models are used frequently for complex flows. Modifications have been made to LEVM such as k-ε in order to improve modeling, but generally, the modifications have only improved modeling of less complex flows. More advanced LEVM models have been developed using elliptic relaxation equations to help resolve these issues.
The ν2-f model was developed to better capture flow physics for complex flows while being applicable to general flows. It is generally considered one of the most accurate LEVMs. It does, however, have issues with stability and robustness. Several improvements have been proposed. One of the most notable is its reformulation into the ζ-f model which offers several improvements while maintaining accurate flow prediction. The model improvement is still limited by being a LEVM. While models, such as differential Reynolds stress models, do exist which are able to capture relevant flow physics in complex flows, modeling difficulties make them impractical for use in a commercial CFD code.
Algebraic Reynolds stress models have attempted to bridge this gap with varying levels of success. The models express the Reynolds stress tensor as a function of different higher level tensors. This is the same process used to derive non-linear eddy-viscosity models which add extra high-order terms to the Boussinesq approximation. According to Kassinos and Reynolds, however, this technique is fundamentally flawed. These models fail to capture all relevant information about the turbulence structure. The Reynolds stresses capture information regarding the turbulent componentiality, i.e. velocity components of turbulence. The dimensionality, which carries information regarding the direction of turbulent eddies, is not modeled, however. Kassinos and Reynolds constructed a structure-based model which attempts to capture turbulent componentiality and dimensionality by expressing the Reynolds stress tensor as a function of one-point turbulence structure tensors. Their original model introduced hypothetical turbulence eddies which could be averaged and then used to relate the eddy-axis transport equation to the proper structure tensors. The ideas behind this model were adapted into several different models including the R-D model and the Q-model. These formulations were able to accurately capture the flow physics for many complex flow types especially those with mean rotation. These resulting models, however, were overly complicated for application in commercial CFD codes. These structure-based models later resulted in the development of the algebraic structure based model (ASBM).
The ASBM was developed in order to ensure computational efficiency while capturing relevant turbulence physics. The ASBM uses an algebraic model for the eddy statistics which is constructed from the local mean deformation and two turbulent scales. The original turbulent scales used were the turbulent kinetic energy and the large scale vorticity. Although the model was calibrated specifically for use with the turbulent kinetic energy and large scale vorticity transport equations, the algebraic model can be used in conjunction with any scalar transport equations as long as the field distribution of turbulent kinetic energy and turbulence time scale can be obtained. Based on its formulation, the ASBM, used in combination with any scalar transport equations, should be applicable to most commercial CFD codes.
The objective of this work was to implement the ζ-f model and ASBM, coupled with k-ε and v2-f, in the commercial CFD solver FLUENT and validate its performance for canonical turbulent flows including a subsonic turbulent flat-plate, S3H4 2D hill, and backward-facing step. Each turbulent flow was evaluated using various turbulence models including Spalart-Allmaras, k-ε, k-ω, k-ω-SST, v2-f, ζ-f and two ASBM formulations and compared against experimental results. The ζ-f model produced improved results for both the flat plate and backward facing step as compared to all two-equation or less turbulence models and showed similar predictive capabilities to the v2-f model. It had difficulties predicting attached flow past the S3H4 2D hill just as the v2-f model. This, however, was expected due to its basis on the v2-f model. The model was also more stable than the v2-f model during calculation of the turbulent flat plate but showed no improvement in robustness for the more complex backward facing step. The semicoupled (linear eddy viscosity model based) v2-f-ASBM’s predictive capabilities were comparable to the two equation models for the turbulent flat plate case. It performed surprisingly well for the backward facing step and matched the experimental data within experimental uncertainty. The model did, however, have problems predicting the S3H4 2D hill just as the with the v2-f model.
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Damasceno, Leonardo Henrique Soares. "Tratamento de soro de queijo no ASBR: influência da estratégia de alimentação." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-10062016-101339/.
Full textAbstract:
Avaliou-se o desempenho do reator anaeróbio em batelada seqüencial com biomassa imobilizada (ASBBR) no tratamento de soro de queijo quanto submetido a diferentes estratégias de alimentação e cargas orgânicas volumétricas (COV). O reator operou com agitação mecânica através de impelidor do tipo hélice na rotação de 500 rpm. Um volume de 2 litros foi alimentado por ciclo com 1 litro de volume residual, totalizando 3 litros. O substrato utilizado foi soro de queijo desidratado reconstituído. Suplementou-se o sistema com NaHCO3 na razão de 50% NaHCO3/DQO. Foram testadas as seguintes COVs: 2, 4, 8 e 12 gDQO/l.d. Para ciclos de 8 horas e em cada COV, três estratégias de alimentação foram testadas: (a) operação em batelada com ciclo de 8 horas, (b) batelada alimentada de 2 horas (c) batelada alimentada de 4 horas. Na COV de 2 gDQO/l.d, a conversão de matéria orgânica como DQO em amostras filtradas foi de 92, 96 e 91% para as estratégias de alimentação (a), (b) e (c), respectivamente. Para a COV de 4 gDQO/l.d, o desempenho foi de 94, 97 e 93%, respectivamente. Para a COV de 8 gDQO/l.d houve redução nas eficiências de conversão a 83, 85 e 86%, respectivamente. O aumento da COV para 12 gDQO/l.d, resultou na redução em eficiências de 72, 73 e 81%, respectivamente. Os perfis durante os ciclos da concentração de ácidos voláteis totais mostraram que, apesar do aumento gradual com o tempo de enchimento aumentando, nenhuma diferença significativa foi detectada em termos dos seus valores máximos. Foi observada a redução de ácido propiônico como conseqüência do aumento do tempo de enchimento. Assim, para COV de 2 e 4 gDQO/l.d, a estratégia de alimentação (b) proporcionou maiores eficiências de conversão e estabilidade operacional, enquanto que este comportamento foi observado na estratégia de alimentação (c) para os valores de COV de 8 e 12 gDQO/l.d.<br>The performance of an anaerobic sequencing batch biofilm reactor (ASBBR) treating cheese whey was evaluated when subjected to different feeding strategies and volumetric organic loads (VOL). The reactor operated under mechanical stirring provided by helix impellers at rotor speed of 500 rpm. A volume of 2 l was fed per cycle with 1 l of residual volume, totalizing 3 l. Reconstituted dehydrated cheese whey was used as substrate. NaHCO3 was supplemented at a ratio of 50% NaHCO3/COD. The following VOLs were tested: 2, 4, 8 and 12 gCOD/l.d. For 8-h cycles and each value of VOL three feed strategies were tested: (a) batch operation with 8-h cycle; (b) 2-h fed-batch operation; and (c) 4-h fed-batch. In the VOL of 2 gCOD/l.d, organic matter conversions as COD were 92, 96 and 91%, for feeding strategies (a), (b) and (c), respectively. For the VOL of 4 gCOD/l.d, performance values were 94, 97 and 93%, respectively. For the VOL of 8 gCOD/l.d there was a reduction in conversion efficiency to 84, 85 and 86%, respectively. The increase of VOL to 12 gCOD/l.d resulted in the reduction in efficiency of 78, 73 and 81%, respectively. The profiles of total volatile acids concentration obtained during the cycles showed that despite its gradual increase with the increasingly filling time, no significant differences were detected in terms of maximum values. Reduction in proprionic acid concentration along the cycle were observed as consequence of the increase of the filling time. Thus, for VOL of 2 and 4 gCOD/l.d feeding strategy (b) provided higher conversion efficiency and operation stability. This behavior was similar to that observed for the feeding strategy (c) at the VOL of 8 and 12 gCOD/l.d.
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Amoedo, André Jorge Vieites. "" Determinação do requisito proteico em juvenis de corvina (Argyrosomus regius, Asso, 1801)"." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62209.
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Nuñez, Ramos Claudio Andrés, and Demetri Paulo Cesar Araya. "Servicios de mantención de aseo y manejo de residuos sólidos industriales (RSI)." Tesis, Universidad de Chile, 2015. http://repositorio.uchile.cl/handle/2250/136933.
Full textAbstract:
Tesis para optar al grado de Magíster en Administración<br>Claudio Andrés Nuñez Ramos [Parte I Análisis estratégico y de mercado], Paulo Cesar Araya Demetri [Parte II Análisis organizativo - financiero ]<br>Este plan de negocio tiene como finalidad desarrollar y presentar una empresa capaz de
responder a la recurrente necesidad industrial de la región metropolitana en materias
relacionadas con el aseo y manejo de residuos industriales.
A lo largo de los años, el aseo industrial ha sido habitualmente externalizado a bajo costo,
incumpliendo las exigencias de la Seremi de salud, y respondiendo pobremente a las
expectativas internas y externas de las empresas. Complementariamente, hoy las
empresas se ven enfrentadas a una mayor regulación en lo que respecta al manejo de
sus residuos - como actividad consecutiva al aseo en esta cadena de valor. Tanto la
comunidad como el gobierno, exigen minimizar los impactos en el entorno y desarrollar
una postura mucho más amigable con el medioambiente.
De esta manera nace SMAR (Servicio de Mantención de Aseo y Manejo de Residuos),
empresa que busca responder a la problemática descrita mediante una solución integral
basada en ambos servicios; apuntando a mejorar la imagen interna-externa de las
empresas, hacer cumplir la ley y disminuir el riesgo por multas o penalizaciones, velar por
la seguridad, la salud ocupacional y los aspectos medioambientales, entregar asesorías,
reemplazar la administración interna por la gestión de contratos, generar sinergias y
ahorros mediante procesos estandarizados, recomendar la tecnología idónea para la
reducción de mano de obra, tiempos de operación y transportes, entre otros.
SMAR ha basado su estrategia esencialmente en la integración y especialización de sus
servicios, investigación e inclusión de tecnología, asesoría y gestión. A modo de
materializar la estrategia, la empresa desarrollará procesos únicos y estandarizados,
alianzas con proveedores claves, contará con un staff de profesionales con experiencia
comercial y operacional en el rubro, y una estructura flexible y escalable en el tiempo.
En relación a la evaluación financiera, con horizonte de 10 años, el proyecto entrega un
VAN positivo de $194.178.000, una TIR de 27%, un ROI de 63% y un PAYBACK de 5,6
años. Las cifras expuestas ratifican que el proyecto SMAR es viable, vale decir, se
recupera la inversión, se obtiene lo exigido y se genera un excedente adicional. Para dar
vida al negocio, el requerimiento de capital inicial asciende a CL $140.000 000.
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Amoedo, André Jorge Vieites. "" Determinação do requisito proteico em juvenis de corvina (Argyrosomus regius, Asso, 1801)"." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62209.
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Nyman, Jonas, and Vladimir Krivokuca. "DESIGN AND CONSTRUCTION OF A STEPLESS HEIGHT ADJUSTER FOR AN ASKO DISHWASHER." Thesis, Högskolan i Skövde, Institutionen för ingenjörsvetenskap, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-17307.
Full textAbstract:
The standard for standing household dishwashers to date includes some means of adjusting the height of the upper basket in order to facilitate a more efficient loading of dishware. Ordinarily this is done by lifting the basket and locking it in a few positions. A more efficient and satisfactory method of handling the elevation that instils a premium sensation was to be developed. A design process was initiated and using CAD, a 3D model with associated drawings was created. A FEM analysis was conducted on the most vital components and a subsequent prototype was built. Preliminary results indicated flaws in the construction, however developing solutions appeared promising. The FEA concluded that the key components were sufficiently dimensioned for the tasks given. In the end, the project requirements were fulfilled although with set conditions modified, and without an end user trial.
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Pettenuzzo, Sara <1996>. "La aventura de Aristómenes en dos traducciones de El asno de oro." Master's Degree Thesis, Università Ca' Foscari Venezia, 2022. http://hdl.handle.net/10579/20874.
Full textAbstract:
La presente tesi ha come oggetto di ricerca lo studio e l’analisi de La Metamorfosi, conosciuta anche come L’asino d’oro, capolavoro dello scrittore latino Lucio Apuleio, composto nel II secolo d.C, celebre soprattutto per Amore e Psiche, una delle favole più suggestive narrata all’interno della suddetta opera. In particolare, si pone attenzione alla vicenda del viandante Aristomene, alla sua lepida fabula e alla funzione della magia, componente di notevole importanza ne L’asino d’oro. Nel corso del romanzo, infatti, presenzieranno streghe, filtri d’amore, maledizioni, incantesimi e superstizioni. A tal proposito, questo lavoro si concentra su due aspetti: dopo una breve introduzione, seguirà una prima parte in cui si darà risalto allo studio e all’influenza di Apuleio in Spagna, più precisamente nella letteratura; mentre nella seconda parte, si farà un’analisi comparativa tra due traduzioni spagnole de L’asino d’oro -la prima di Diego López de Cortegana (1500) e la seconda di Lisardo Rubio Fernández (1978)- dove si analizzeranno gli aspetti testuali, gli aspetti semantici, le criticità incontrate e le strategie adottate. La tesi verrà ultimata da una conclusione che riprenderà i punti chiave del lavoro di ricerca.
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Rodríguez, Sáez Maria Elena. "Identificación de las causas de la rotación de auxiliares de aseo de la ciudad de Rancagua que influyen en la declaración de permanencia en la empresa." Tesis, Universidad de Chile, 2018. http://repositorio.uchile.cl/handle/2250/168509.
Full textAbstract:
Tesis para optar al Grado de MAGÍSTER EN GESTIÓN DE PERSONAS Y DINÁMICA ORGANIZACIONAL<br>GGP Servicios Industriales SPA perteneciente al Holding C&G Servicios Industriales. Este grupo
empresarial está compuesto por 3 empresas de servicios, con más de 20 años de experiencia, se ha
posicionado como una empresa referente de la industria.
La rotación del personal es un problema significativo y agobiante que enfrenta GGP Servicios
Industriales SPA. Los costos asociados a la rotación de personal afectan tanto a nivel comercial como a
nivel administrativo y de imagen corporativa. Se califica la rotación y falta de permanencia como un bajo
compromiso laboral de los trabajadores hacia nuestra empresa, instalándose esta percepción en nuestro
diario vivir generando distancias considerables entre el estado actual y el deseado de la organización.
La rotación dejaría rastros evidentes de falta de compromiso laboral de los trabajadores y una baja tasa
de permanencia. Teniendo en cuenta el porcentaje de representación de trabajadores de esta empresa
dentro del holding la rotación de personal se constituye en un flagelo que incide inevitablemente a las
demás empresas del Holding al cual pertenece.
Por otro lado, desde el rol de profesional del área de Gestión de Recursos Humanos, ha sido posible
reconocer la soledad, situación de aislamiento e invisibilidad de las personas en su función. Esta
invisibilidad se reconoce, tanto en las personas a las cuales sirve el auxiliar de aseo (usuarias del
servicio), como para la organización misma. Por otro lado, la condición de empleado de una empresa
subcontratada constituye una situación laboral que incrementa la invisibilidad. El trabajador
subcontratado es un nómade laboral que sufre con los rigores de no contar con una afiliación clara de
donde pertenece” (Acuña & Silva, 2008, p. 113).
La reflexión desarrollada los últimos seis años, desde el rol de Subgerente de Recursos Humanos en la
empresa, motiva la elección de la temática del proyecto. Resulta urgente para esta organización poder
investigar los motivos que llevan al personal a tener una baja permanencia en la organización. La
relevancia de esta temática se fundamenta, tanto en los efectos que tiene la rotación en la organización,
como las condiciones que experimentan los trabajadores de la empresa y que se constituirían en causa
de su baja permanencia
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Georgiou, George. "Corporate lobbying behaviour in the ASB standard-setting process." Thesis, University of Aberdeen, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.322590.
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Schimanski, Silke Veronika [Verfasser]. "Biotechnologische Erzeugung natürlicher Aromastoffe aus Submerskulturen von Asco- und Basidiomyceten / Silke Veronika Schimanski." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2014. http://d-nb.info/1069207853/34.
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Gustafsson, Henrik. "Rationellare hantering av plåtdetaljer från pressline 1 till aktuellt monteringsställe." Thesis, University West, Department of Technology, Mathematics and Computer Science, 2006. http://urn.kb.se/resolve?urn=urn:nbn:se:hv:diva-796.
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Albert, Caro Cynthia. "Validación del inventario de sensibilidad ambiental y corporal de Schienle, Walter, Stark y Vaitl en un grupo de estudiantes de la ciudad de Lima." Bachelor's thesis, Universidad Ricardo Palma, 2018. http://cybertesis.urp.edu.pe/handle/urp/1399.
Full textAbstract:
La presente investigación es un trabajo de validación del “Inventario de sensibilidad ambiental y corporal” de Schienle, Walter, Stark y Vaitl (2002), también conocida en su lengua original como “Fragebogen zur Erfassung der Ekelempfindlichkeit” (FEE), cuyo objetivo es medir la emoción del asco. La prueba fue traducida del alemán al castellano por el Doctor Ramón León Donayre.
La relevancia de validar un inventario que evalúe el asco radica en que, probablemente, se trate de la emoción acerca de la que menos se haya investigado, o sobre la que se ha sistematizado en menor cuantía el conocimiento derivado de su estudio. Sin embargo, entendemos que es de mucha relevancia en el campo clínico ya que se trata de una emoción que se encuentra presente en diversas patologías. Este inventario podría tener un alto valor predictivo además de mucha utilidad en la correlación de sus resultados con los de otros inventarios como los de personalidad.
Con el fin de validar la prueba la encuesta fue aplicada a una muestra de 588 sujetos representada por 313 mujeres y 275 hombres. Los resultados obtenidos reflejan que el “Inventario de sensibilidad ambiental y corporal” posee un alto grado de confiabilidad, representado por un Alfa de Cronbach de ,939.
present research is a validation work of the “Questionnaire for the assessment of disgust sensitivity” developed by Schienle, Walter, Stark and Vaitl (2002), also known in its original language as "Fragebogen zur Erfassung der Ekelempfindlichkeit" (FEE). The test was translated from German into Spanish by Dr. Ramón León Donayre.
The relevance of validating a questionnaire that assess the emotion of disgust is, probably, that disgust might be the emotion that has been less investigated or to which the knowledge derived from its study has been systematized to a lesser extent. Nevertheless, we understand that it is of great relevance in the clinical field since disgust is an emotion that is present in diverse pathologies. This questionnaire could have a high predictive value and a lot of usefulness in the correlation of its results with those of other inventories such as, for example, personality tests.
The survey was applied to a sample of 588 subjects represented by 313 women and 275 men.
The validation of the instrument shows that the it has a high degree of reliability, represented by a Cronbach alpha of ,939.
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Nilsson, Ebony Grace. "The ‘Enemy Within’: Left-wing Soviet Displaced Persons in Australia." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24375.
Full textAbstract:
In the wake of the Second World War, Soviet displaced persons (DPs) from Europe and Russians displaced from China were resettled across Western nations. Their migration coincided with the escalating geopolitical tensions of the early Cold War, which in an Australian context turned migrants of Soviet origin into potential ‘enemy aliens.’ Soviet DPs have generally been considered virulently anti-communist, as indeed many were. Others developed their anti-communist narratives as they negotiated displacement, emphasising beliefs which were expedient and keeping quiet about those that were not. But despite the pressures of the early Cold War, a minority of Soviet DPs actively engaged with left-wing politics after arriving in Australia. These DPs’ political activities resisted the Australian government’s expectations of migration assimilation. Their convictions oriented them back toward a Soviet homeland and resulted in dual loyalties which appeared dangerous in Cold War Australia. Thus, left-wing DPs negotiated not only politics, but state suspicion regarding their loyalties and the surveillance of the Australian Security Intelligence Organisation (ASIO).
This dissertation reconstructs the political and social experiences of individual Soviet DPs throughout the processes of displacement and migration. Through biography and individual experience, it traces the development of politics across continents and the interactions with intelligence which resulted. I argue that despite the Australian state’s expectation that migrants would assimilate and develop loyalty (solely) to their new home, some DPs maintained their dual loyalties and orientation toward an ‘enemy’ homeland, co-existing with attitudes to Australia that ranged from alienation to acceptance.
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Au, Chun-hei Victor, and 區晉熙. "The role of ankyrin repeats and SOCS box protein 4 (ASB4) in hepatocellular carcinoma." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2013. http://hdl.handle.net/10722/196475.
Full textAbstract:
Hepatocellular carcinoma (HCC)is one of the commonly diagnosed cancers in the world. Most patients have poor prognosis due to late detection of disease. Ankyrin repeat and suppressor of cytokine signaling box protein 4(ASB4), as a member of the ASB family, possesses two domains, ankyrin repeat (AR) and suppressor of cytokine signaling (SOCS)box, which are responsible for recruiting the target proteins for proteasomal degradation. Previous study has demonstrated high expression level of ASB4 in metastatic HCC cells, implicating the properties of ASB4 in cancer invasiveness. With this hypothesis, various experiments were performed in this research project to elucidate the functional roles of ASB4 in HCC cells. The aim of this study is to characterize the roles of ASB4 in HCC by manipulating its expression level in HCC cell lines through gene knockdown and over-expression. Altering the level of ASB4 in HCC cells resulted in no significant effects on the cell proliferation rates. However, ASB4 was demonstrated to promote migration and invasion properties of HCC cells, as suppression of its level led to slower migration and made cells less invasive. Opposite effects on cell migration and invasion were observed when ASB4 was ectopically expressed. Regarding the regulatory mechanism of ASB4, miR-200a was demonstrated to be a negative regulator for ASB4. In summary, ASB4 is probably involved in the migration and invasion properties of HCC cells, and also, being regulated by miR-200a.<br>published_or_final_version<br>Surgery<br>Master<br>Master of Philosophy
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Velazco, Vargas Jorge Luis. "Contribución al estudio de las necesidades nutritivas de la corvina (Argyrosomus regius, Asso 1801)." Doctoral thesis, Universitat Politècnica de València, 2014. http://hdl.handle.net/10251/35446.
Full textAbstract:
La corvina es una especie carnívora que se ha incorporado a la producción de la
acuicultura en el Mar Mediterráneo, por sus altos índices de crecimiento y calidad de la carne.
Por la poca información nutricional existente para esta especie, se ha introducido en su
producción la experiencia que ya se tiene en la dorada y la lubina. Los objetivos de esta tesis
doctoral fue determinar las necesidades nutritivas de la corvina y estudiar la inclusión del turtó
de soja como una fuente proteica vegetal alternativa de la harina de pescado.
Para determinar las necesidades de proteína y energía se trabajó con un pienso
comercial, se experimentó con dos grupos de peces (53 y 200 g), en donde se aplicó un modelo
factorial, obteniendo que las necesidades de mantenimiento para la proteína fue de 0,0617 g PD
100 g pez-1 día-1 y para la energía de 2.74 kJ ED 100 g pez-1 día-1. Las necesidades para el
máximo crecimiento de la proteína fue de 0,64 g PD 100 g pez-1 día-1 y de energía 38.5 kJ ED
100 g pez-1 día-1. Con peces de 52 g, se realizó el estudio del efecto de los niveles de la proteína
digestible (35%, 43%, 49% y 53%), los peces alimentados con piensos con niveles de 43%,
49% y 53% de proteína digestible, obtuvieron los mejores crecimientos (Coeficiente térmico de
crecimiento = 2,47, 2,57 y 2.69 x 10-3, respectivamente). El nivel óptimo de proteína digestible
ingerida para juveniles de corvina fue de 0,8 g PD 100 g pez-1 día-1. Para determinar la relación
Proteína/Energía se experimentaron con peces de 147 g en jaulas marinas y fueron alimentados
con piensos de 47/20, 51/28 y 55/17, obteniendo los mejores crecimientos e índices de
conversión con el pienso 47/20.
Para estudiar la inclusión del turtó de soja en la corvina se realizaron dos fases de
investigación. En una primera fase se utilizaron 800 peces de 165 g, durante 107 días fueron
alimentados con cuatro piensos isoproteíco (50% de proteína bruta) e isolípidico (17% de grasa
bruta), con niveles de inclusión del 0, 15, 30 y 45% de turtó de soja. En los piensos del 15 y
30% de turtó de soja se obtuvieron los mejores resultados y de acuerdo a la regresión cuadrática
el nivel óptimo de inclusión de turtó de soja fue del 27.6%. La relación entre el porcentaje de
aminoácidos esenciales de la dieta y el porcentaje de aminoácidos esenciales a nivel corporal de
los peces presentó deficiencias en arginina, lisina, treonina y principalmente de metionina. En la
segunda fase se utilizó la misma metodología que en el primer experimento, pero utilizando 300
peces de 346 g de media durante 26 días. Los resultados muestran que la corvina presentó un
alto crecimiento (Coeficiente térmico de crecimiento = 4,00 x 10-3) y se recomienda una
inclusión de turtó de soja de entre un 30 ¿ 45%.
En base a los resultados obtenidos, se propone un pienso para Argyrosomus regius de
47% de proteína bruta, 17% de grasa bruta y un 30% de inclusión de turtó de soja,
suplementado con metionina y lisina, con el fin de obtener altos crecimientos, disminuir el uso
de la harina de pescado y hacer más rentable la producción acuícola de esta especie en el Mar
Mediterráneo<br>Velazco Vargas, JL. (2014). Contribución al estudio de las necesidades nutritivas de la corvina (Argyrosomus regius, Asso 1801) [Tesis doctoral no publicada]. Universitat Politècnica de València. https://doi.org/10.4995/Thesis/10251/35446<br>TESIS
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Heuzé, Mélina. "Mécanismes d'action de l'ubiquitine ligase ASB2 au cours de la différenciation des cellules hématopoïétiques." Paris 7, 2007. http://www.theses.fr/2007PA077154.
Full textAbstract:
Le gène Asb2 a initialement été identifié comme un gène activé au cours de la différenciation induite de cellules leucémiques. L'objectif de mon travail de thèse était de caractériser les mécanismes d'action de la protéine ASB2. La dégradation sélective d'une protéine par le protéasome nécessite son ubiquitinylation préalable qui met en jeu trois enzymes dont une E3 ubiquitine ligase responsable de la reconnaissance spécifique de la protéine cible. Nous avons montré que la protéine ASB2 est la sous-unité de spécificité d'un complexe E3 ubiquitine ligase multimérique de type Culline/RING finger. De plus, nous avons identifié un premier substrat d'ASB2: la filamine A, une protéine multifonctionnelle qui constitue une véritable plateforme régulatrice entre des récepteurs transmembranaires et le cytosquelette d'actine. Nous avons montré que la protéine ASB2 induit l'ubiquitinylation et la dégradation de la filamine A par le protéasome et avons révélé un lien entre ASB2 et la signalisation des intégrines. Ainsi, à travers la dégradation de la filamine A, ASB2 pourrait moduler l'ancrage et la motilité des cellules souches au sein de la niche médullaire. De plus, nous avons découvert l'existence d'une nouvelle isoforme d'ASB2, ASB2beta, exprimée spécifiquement dans les cellules musculaires et requise pour la différenciation musculaire in vitro. Ces travaux apportent une nouvelle preuve de l'importance du système Ubiquitine-Protéasome dans la régulation de l'hématopoïèse et de la myogénèse. Au cours de ces deux événements, les protéines ASB2alpha et ASB2beta, respectivement, pourraient ubiquitinyler et cibler à la dégradation certains régulateurs négatifs de la différenciation<br>The gene Asb2 was initially identified as a gene activated during induced differentiation of leukemia cells. The aim of my phD was to characterize ASB2 mechanisms of action. In cells, ubiquitination of a protein is generally a prerequisite to its proteasomal degradation and employs three enzymes, of which an E3 ubiquitin ligase responsible for the spécific recognition of the target protein. We demonstrated that ASB2 is the specificity subunit of a multimeric Cullin/RING finger-type E3 ubiquitin ligase complex. Moreover, we have identified a first substrate of ASB2 ubiquitin ligase activity: the multifunctional filamin A protein, which constitutes a regulatory platform between transmembrane receptors and actin cytoskeleton. We showed that the ASB2 protein induced filamin A ubiquitination and subsequent proteasomal degradation. We also revealed a function of ASB2 in integrin signalling. Altogether, these results suggest that through filamin A degradation, ASB2 can modulate stem cells anchor and motility within the bone marrow niche. Finally, we discovered a novel isoform of ASB2, ASB2beta, specifically expressed in muscle cells and required for muscle differentiation in vitro. This work is a new demonstration of the importance of the Ubiquitin-Proteasome System in regulation of hematopoiesis and myogenesis. During these two processes, ASB2alpha and ASB2beta, respectively, may ubiquitinate specific negative differentiation regulators leading to their proteasomal degradation
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Ferguson, James Edward Patterson Cam. "Investigating the role of ankyrin repeat and SOCS box protein 4 (ASB4) during vascular development." Chapel Hill, N.C. : University of North Carolina at Chapel Hill, 2007. http://dc.lib.unc.edu/u?/etd,1230.
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Thesis (Ph. D.)--University of North Carolina at Chapel Hill, 2007.<br>Title from electronic title page (viewed Mar. 26, 2008). "... in partial fulfillment of the requirements for the degree of Doctor of Philosophy in the Department of Pharmacology." Discipline: Pharmacology; Department/School: Medicine.
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Zhang, Yongheng. "Membrane topology and structure-function relationship of the Apical Sodium-dependent Bile Acid Transporter, ASBT /." The Ohio State University, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=osu1486401895210192.
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Junior, Roberto Antonio Bezerra. "Estabilidade e eficiência de um reator anaeróbio de leito fixo com agitação operado em batelada seqüencial em função da diluição inicial de esgoto sintético." Universidade de São Paulo, 2004. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-20042016-095657/.
Full textAbstract:
Dentro do escopo de estudo de aspectos fundamentais e tecnológicos, este trabalho foi direcionado à avaliação do comportamento da estabilidade e da eficiência de um reator anaeróbio contendo biomassa imobilizada em espuma de poliuretano para o tratamento de água residuária sintética com concentração de aproximadamente 500 mgDQO/L. O reator, de 6 litros de volume nominal, mantido à temperatura de 30 +/- 1ºC e sob a agitação mecânica de 500 rpm, foi operado em bateladas seqüenciais com a renovação de apenas parte do volume de água residuária tratada por ciclo, ou seja, a descarga do reator não foi completa, mas apenas parcial. Neste contexto, a principal característica operacional investigada foi a relação entre o volume de água residuária afluente, o qual era alimentado a cada novo ciclo de operação, e o volume de meio contido no reator, o qual não era descarregado no ciclo anterior, mantendo-se a mesma carga orgânica volumétrica. Desta forma, foi possível verificar a flexibilidade operacional do sistema com relação ao volume de água residuária tratada a cada ciclo e o tempo de duração do ciclo para uma mesma carga orgânica. Os resultados indicaram que o reator pôde operar com diferentes relações entre o volume alimentado e o volume de meio reacional sem diminuição significativa do seu desempenho, permitindo-se, assim, maior flexibilidade operacional. Para as condições em que o volume renovado foi maior ou igual a 50% do volume de meio do reator (ciclos de 4 a 8 horas), as eficiências de remoção de matéria orgânica filtrada e não filtrada mantiveram-se no patamar de 84 e 79%, respectivamente, enquanto que nas demais condições de maior diluição inicial do afluente (ciclos de 1 e 2 horas), essas eficiências foram ligeiramente menores, em torno de 80 e 74%, respectivamente. A alta velocidade de formação de material viscoso de aparência polimérica, nas condições de maior diluição inicial do afluente, dificultou a manutenção do volume de meio reacional do reator constante.<br>An assessment was performed on the stability and efficiency of an anaerobic reactor containing biomass immobilized on polyurethane foam for the treatment of synthetic wastewater with organic loading of approximately 500 mgCOD/L. The reactor had a total volume of 6 L. Batch operation took place at a temperature of 30 +/- 1ºC and an agitation rate of 500 rpm. During operation only part of the treated wastewater was renewed per cycle, i.e., reactor discharge was not complete, but partial. The main operation characteristic investigated was the ratio between influent wastewater volume, which was fed at each cycle, and the volume of medium contained in the reactor, which had not been discharged in the previous cycle, maintaining the same volumetric organic load. This way, it was possible to verify operation flexibility of the system regarding treated wastewater volume in each cycle as well as cycle time duration for the same volumetric organic loading. Results indicated that the reactor was able to operate at different ratios between feed and reaction medium volume without significant loss in performance, allowing, hence, greater operation flexibility. For conditions at which renewed volume was greater than or equal to 50% of the reactor medium (cycles from 4 to 8 hours), filtered and non-filtered organic matter removal efficiencies were about 84 and 79%, respectively, whereas at conditions of higher initial influent dilution (cycles from 1 to 2 hours) these efficiencies were slightly lower, about 80 and 74%, respectively. The high formation rate of viscous polymer-like material probably of microbiological origin, at the conditions of higher initial influent dilution hindered maintenance of constant reactor medium volume.
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OTTONE, TIZIANA. "La mutazione di tipo A della nucleofosmina nella diagnosi e nel follow-up della leucemia mieloide acuta." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2009. http://hdl.handle.net/2108/1135.
Full textAbstract:
Acute myeloid leukaemias (AML), which account for about 80% of the acute leukaemias in adult, represent a phenotypically and genetically heterogeneous group of clonal haematopoietic diseases in which, failure to differentiate and over proliferation in the stem cell/progenitor compartment, result in accumulation of non-functional myeloblasts. Nucleophosmin-1 (NPM1) mutations is the most frequent gene alteration in AML (30%), and are particularly frequent in AML with normal karyotype (AML-NK) (60%). These alterations have been shown to carry prognostic significance because they seem to identify patients with better response to chemotherapy. As a consequence, the analysis of NPM1 mutational status is now recommended for inclusion in the genetic routine characterization of AML (Gorello P. et al., Leukemia 2006; Ammatuna E. et al., Clin Chem 2005; Nelida I.N. et al., Leukemia 2005; Scholl S. et al., Leuk Res 2007; Lin LI et al., Leukemia 2006).
Finally, given their high prevalence and stability over the course of the disease, NPM1 mutations may serve as an ideal target for minimal residual disease (MRD) assessment, particularly for patients with AML-NK (Gorello P. et al., Leukemia 2006).
In early 2005, Falini et al. (Falini B. et al., New Engl J Med 2005) reported that NPM1 gene mutations, mainly consisting of small nucleotide insertion/deletions, occur frequently in AML and are strongly associated with NK. Over 40 different types of mutations in the NPM1 (NPM1m) locus have been described so far, which result in the formation of different mutant proteins. This alterations consist of the insertion/deletion of short nucleotide stretches (4 or 10 bps) after nucleotide position 956 in NPM1 exon 12 that lead to an ORF shift resulting in different protein variants containig novel C-terminus portions. The most common NPM1 mutation is the type A (NPM1 mut-A), accounting for 75% - 85% of cases, and consist of duplication of a TCTG tetranucleotide at position 956 to 959 of the reference sequence (GenBank accession number NM_002520).
Available methods to detect nucleophosmin mutations are costly, require sophisticated equipment, and are often less sensitive. The aim of this work was to develop two assays that enable rapid and sensitive detection of NPM1 mut-A (Ottone T. et al., Genes Chromosomes Cancer 2009): a fragment analysis method and an RT-ASO-PCR (Reverse Trascriptase Allele Specific Oligonucleotide Polymerase Chain Reaction) method. Furthermore a semi-nested ASO-PCR method was also designed in order to increase the sensitivity of our assay for the monitoring of MRD.
After informed consent, bone marrow and peripheral blood cells were collected at presentation from 107 patients with AML diagnosed at the Institute of Hematology, Department of Biopathology of the University Tor Vergata of Rome. For each patient reverse trascribed cDNA was divided into three aliquotes used for capillary elettrophoresis, sequencing and ASO-PCR. Semi-nested ASO-PCR experiments were carried out using RT-ASO-PCR products. For capillary electrophoresis fluorescent labeled PCR products were used to screen for the presence of NPM1 mutations using the CEQTM 8000 Genetic Analysis Sistem (Beckman Coulter) instrument. Electroferogram showed 348 bp and 352 bp fragment size, corresponding to NPM1wt and NPM1m, respectively. OCI-Aml3 cell line was used as a positive control. The sensitivity of method was tested using the following serial dilutions of the mutated with wild type allele: 0.01, 0.10, 0.25, 0.50, 0.75, 1.00 (mut/wt). To confirm fragment analysis results, 17 NPM1m and 10 NPM1wt samples were sequenced: cDNA were amplified and the products, after purification, were prepared for sequencing using the CEQTM 8000 instrument.
With the aim of analyzing the presence of type A mutation in NPM1 exon 12, an RT-ASO-PCR strategy was used. A forward primer was designed to specifically amplify NPM1 exon 12 only if the mutation A is present; this primer in fact contains an intentional mismatch at third nucleotide from 3’ end to improve specificity. The amplified region includes the insertion of a TCTG tetranucleotide and corresponds to a 320 bp amplified product. As internal PCR control the ABL housekeeping gene was also amplified in each sample.
In order to increase the sensitivity for the assay for MRD monitoring, we set up a semi-nested ASO-PCR; for this purpose an internal forward primer NPM-AN for NPM1 mut-A was designed, corresponding to a 319 bp amplified fragment.
Fragment analysis allowed to identify 17 NPM1m samples. All the NPM1m samples were heterozygous confirming that NPM1m allele is negative dominant. As concerning sensitivity method enabled to detect the NPM1 mutations present in concentration of 10-2.
Sequencing analysis confirmed in all instances NPM1m and NPM1wt cases, showing that 12 samples harboured the most frequent type A mutation, the remaining mutated samples showing type B (3 cases), type D (1 case) and type K mutation (1 case).
RT-ASO-PCR assay confirmed the capillary electrophoresis and sequencing results, showing a concordance in 100% of cases; in fact this method identified the 12 out of 17 NPM1m samples as NPM1 mut-A, with an overall frequency of 70%.
The semi-nested ASO-PCR assay was carried out to increase the sensitivity of this assay for the monitoring of MRD. The sensitivity calculated for both methods, RT-ASO-PCR and semi-nested ASO-PCR, indicated that this assays could detect the NPM1 mut-A present in concentration of 10-2 and 10-5, respectively.
Out of 107 patients, cytogenetic data were available for 99 patients, divided into 2 groups: a group (n=15) consisting of NPM1m and a group (n=84) with NPMwt. Twenty seven out of 99 had normal karyotype. Amongst twenty seven, 13 were NPM1m with an incidence of 48%.
The capillary electrophoresis assay developed in this work proved to be a fast, reproducible and easy method applicable to NPM1m diagnosis, capable to discriminate 1 mutated cell out of 100. RT-ASO-PCR and the more sensitive semi-nested ASO-PCR were developed for specifically detect NPM1mut-A, the most frequent NPM1 mutation. These methods were capable to detect 1 mutated cell out of 100 and out of 100.000, respectively.
Monitoring more patients by these new assays in MRD longitudinal studies could be relevant for better assess molecular remission and the risk of relapse in AML-NK.
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Bengtsson, Peder. "Increasing the value of household appliances by adding a heat pump system." Licentiate thesis, Karlstads universitet, Institutionen för ingenjörs- och kemivetenskaper, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-33596.
Full textAbstract:
Historically, domestic tasks such as preparing food and washing and drying clothes and dishes were done by hand. In a modern home many of these chores are taken care of by machines such as washing machines, dishwashers and tumble dryers. When the first such machines came on the market customers were happy that they worked at all! Today, the costs of electricity and customers’ environmental awareness are high, so features such as low electricity, water and detergent use strongly influence which household machine the customer will buy. One way to achieve lower electricity usage for the tumble dryer and the dishwasher is to add a heat pump system. The function of a heat pump system is to extract heat from a lower temperature source (heat source) and reject it to a higher temperature sink (heat sink) at a higher temperature level. Heat pump systems have been used for a long time in refrigerators and freezers, and that industry has driven the development of small, high quality, low price heat pump components. The low price of good quality heat pump components, along with an increased willingness to pay extra for lower electricity usage and environmental impact, make it possible to introduce heat pump systems in other household products. However, there is a high risk of failure with new features. A number of household manufacturers no longer exist because they introduced poorly implemented new features, which resulted in low quality and product performance. A manufacturer must predict whether the future value of a feature is high enough for the customer chain to pay for it. The challenge for the manufacturer is to develop and produce a high-performance heat pump feature in a household product with high quality, predict future willingness to pay for it, and launch it at the right moment in order to succeed. Tumble dryers with heat pump systems have been on the market since 2000. Paper I reports on the development of a transient simulation model of a commercial heat pump tumble dryer. The measured and simulated results were compared with good similarity. The influence of the size of the compressor and the condenser was investigated using the validated simulation model. The results from the simulation model show that increasing the cylinder volume of the compressor by 50% decreases the drying time by 14% without using more electricity. Paper II is a concept study of adding a heat pump system to a dishwasher in order to decrease the total electricity usage. The dishwasher, dishware and water are heated by the condenser, and the evaporator absorbs the heat from a water tank. The majority of the heat transfer to the evaporator occurs when ice is generated in the water tank. An experimental setup and a transient simulation model of a heat pump dishwasher were developed. The simulation results show a 24% reduction in electricity use compared to a conventional dishwasher heated with an electric element. The simulation model was based on an experimental setup that was not optimised. During the study it became apparent that it is possible to decrease electricity usage even more with the next experimental setup.
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Olsson, Astrid. "ASB lika med SAB? En jämförelse av dokumenttitlar i de båda klassifikationssystemen." Thesis, Högskolan i Borås, Institutionen Biblioteks- och informationsvetenskap / Bibliotekshögskolan, 2003. http://urn.kb.se/resolve?urn=urn:nbn:se:hb:diva-20974.
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The purpose of this Masters thesis is to compare the scheme structure of two national classifications system, namely the Swedish SAB system and the German ASB. It has been assumed that there are no major differences between the two models of classification systems or the main classes into which documents are placed. The classification theory and subject analysis, which form the basic theory on which my research is based, are taken from Dahlberg, Langridge and Rowley. A comparison of 30 monographs classified in the SAB system Sveriges allmänna biblioteksförening and in the German ASB system Allgemeine Systematik für öffentliche Bibliotheken showed that the classification structure was primarily responsible for determining where a particular document was placed. However, despite the fact that the subject in various documents may be similar, my research will demonstrate that the structure of the two codes also depends on different interpretations of the main subject in a document. My conclusion is that is not only the model of the classification system that determines the result of a classification, but also the extent of previous knowledge and the depth of interest for the subject being classified, held by the classifier.<br>Uppsatsnivå: D
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Codognato, Débora Cristina Kawasaki. "Interação da albumina de soro bovino (ASB) com fotossensibilizadores usados em fotoquimioterapia." Universidade de São Paulo, 2017. http://www.teses.usp.br/teses/disponiveis/59/59135/tde-01112017-162951/.
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A Fotoquimioterapia (FQT) vem sendo usada no tratamento de várias doenças, inclusive câncer, com a vantagem de ser menos agressiva, possuindo efeitos colaterais negativos desprezíveis. Esta técnica envolve a combinação de uma fonte de luz visível e de um fotossensibilizador (FS), que é reativo apenas sob a irradiação com luz adequada, e que se acumula preferencialmente no tecido doente. Uma ideia para deixar essa técnica mais eficiente é potencializar esta última característica do FS com uso de um carreador que tenha afinidade com tecidos doentes. Pensamos na hipótese de usar a albumina do soro como carreador uma vez que ela é uma proteína intrínseca do organismo, tem alta afinidade com os tecidos tumorais e possui sítios para ligar vários compostos extrínsecos. Como modelo usamos a albumina de soro bovino (ASB). Como FS utilizamos acridina laranja, nitrofurantoína, corantes ciânicos com dois cromóforos e protoporfirina IX (PpIX) sintética e extraída de glândulas Harderianas de ratos da linhagem Wistar (PpIX endógena). Foram analisadas as características de ligação entre os FS e a ASB e seus efeitos nas características fotofísicas dos FS em função da sua estrutura, utilizando espectroscopias de absorção ótica, fluorescência estática e resolvida no tempo e a técnica de microscopia de imagens por tempo de vida da fluorescência (FLIM). Foi mostrado que a ligação com ASB induz ao deslocamento batocrômico dos espectros de absorção e da fluorescência, aumentando a intensidade e o tempo de vida de fluorescência dos FS. Características como carga positiva, estrutura linear e tamanho pequeno da molécula do FS favorecem sua ligação com a ASB. Uma comparação entre PpIX sintética e endógena mostrou que a formação de um complexo da PpIX com estruturas anfifílicas também aumenta a probabilidade da sua ligação com a ASB. Os resultados obtidos mostraram que a ASB se liga efetivamente aos FS de diferentes estruturas e pode ser usada como carreador dos mesmos para tecidos tumorais.<br>Photochemotherapy (PCT) is used for the treatment of various diseases, including cancer, with the advantage of being less aggressive with reduced adverse effects. This technique includes the use of a visible light source and a photosensitizer (PS), which is reactive only under light exposure and localizes preferably in abnormal tissues. To make this technique more efficient it is necessary to increase the PS content in these tissues using a carrier which possesses affinity with these tissues and is able to bind PS. A good opportunity is to use serum albumin as a carrier since it is an intrinsic protein, has high affinity to tumor tissues and possesses sites for binding of various extrinsic compounds. In this work the bovine serum albumin (BSA) was used as a carrier model. Acridine orange, nitrofurantoin, cyanine dyes with two chromophores and protoporphyrin IX synthetic and extracted from Harderian glands of Wistar line rats (endogenous) were used as PS. The characteristics of the PS binding with BSA and the effect of this interaction on PS photophysical properties were studied using optical absorption, steady-state and time resolved fluorescence spectroscopies, and fluorescence lifetime image microscopy (FLIM). It was demonstrated that PS binding with BSA produces a bathochromic shift in the PS absorption and fluorescence spectra and increases its fluorescence intensity and lifetime. The positive charge, linear structure and small size of the PS molecule favors its binding with BSA. A comparison between synthetic and endogenous PpIX demonstrates that complexation of PpIX molecule with an amphiphilic structure increases the probability of its binding with BSA. The obtained results demonstrate that BSA binds effectively PS with different molecular structures and it is promising for their transport to tumor tissue.
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Nies, Silke Marie [Verfasser]. "Tryptophanabhängige Synthese von indolhaltigen Pigmenten bei verschiedenen humanpathogenen Asco- und Basidiomyceten / vorgelegt von Silke Marie Nies." Giessen : VVB Laufersweiler, 2006. http://d-nb.info/988661799/34.
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曾可澄 and Ho-ching Felice Tsang. "Identification of ankyrin repeats and SOCS box protein 4 (ASB4) as oncogenic biomarker in liver cancer." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2008. http://hub.hku.hk/bib/B40738814.
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Tsang, Ho-ching Felice. "Identification of ankyrin repeats and SOCS box protein 4 (ASB4) as oncogenic biomarker in liver cancer." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B40738814.
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Thirtle, Michael R. "Seeing the lighthouse-- as simple as the ASBC? facilitating organizational change in the U.S. Air Force /." Santa Monica, CA : Rand, 1999. http://catalog.hathitrust.org/api/volumes/oclc/42905356.html.
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Borges, Alisson Carraro. "Influência da estratégia de alimentação no desempenho do reator anaeróbio em batelada seqüencial contendo biomassa imobilizada." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-04042005-174049/.
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Submeteu-se um reator anaeróbio operado em batelada seqüencial a diferentes tempos de enchimento, com o objetivo de verificar-se o desempenho do sistema. O reator, construído em acrílico e com capacidade de 6,3 L, tratou por ciclo um volume de 2,5 L de esgoto sintético com concentração de aproximadamente 500 mgDQO/L. O sistema foi operado à temperatura de 30 graus mais ou menos 1, com duração de 8 h para cada ciclo (tC) e agitação de 500 rpm implementada mecanicamente. Cubos de espuma de poliuretano foram usados como suporte para imobilização da biomassa. No início de cada ciclo, o reator foi carregado com 60 % do volume do esgoto; o restante foi preenchido durante tempos de enchimento (tF) que caracterizaram as diferentes estratégias de alimentação. Os resultados obtidos demonstram que para razões tF/tC <= 0,5 o sistema alcança médias de remoção de matéria orgânica acima de 75 % e 70% para amostras filtradas e não filtradas, respectivamente. Nos ensaios em que tF/tC > 0,5, registrou-se perda na eficiência e formação de polímeros extracelulares, apesar da estabilidade observada. O estudo contribuiu para o melhor entendimento do sistema e definição de técnicas de operação em futuras aplicações.<br>An anaerobic sequencing batch reactor was operated at different fill times with the objective to asses system performance. The reactor, made of plexiglas and with a capacity of 6.3 L, treated per cycle 2.5 L of synthetic wastewater with a concentration of nearly 500 mgCOD/L. The system was operated at a temperature of 30oC, with 8-h cycles (tC) and mechanical agitation rate of 500 rpm. Cubic particles of polyurethane foam were used as support material for anaerobic biomass immobilization. At the start of each cycle, the reactor was fed with 60 % of the wastewater volume, the remainder was filled at different feeding times (tF) that characterized the different feeding strategies. The results obtained showed that for a ratio of tF/tC <= 0.5 the system attained average filtered and non-filtered substrate removal efficiency of 75 % and 70 %, respectively. Ratios of tF/tC > 0.5, resulted in loss in efficiency and formation of extra cellular polymers, in spite of system stability. The study contributed to a better understanding of the system and definition of operational techniques for future applications.
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Lapa, Katt Regina. "Avaliação de desempenho do reator anaeróbio em batelada seqüencial (ASBR), contendo biomassa imobilizada em pedra pome, para tratamento de esgoto sanitário." Universidade de São Paulo, 2003. http://www.teses.usp.br/teses/disponiveis/18/18138/tde-30082004-112743/.
Full textAbstract:
Os reatores anaeróbios em batelada (ASBR) de leito fixo, em desenvolvimento no Instituto Mauá de Tecnologia e na Escola de Engenharia de São Carlos, têm apresentado desempenho satisfatório no tratamento de esgotos sanitários. A escolha do leito suporte é um dos importantes aspectos dessa etapa de desenvolvimento, além do aprofundamento do conhecimento dos aspectos fundamentais do processo e daqueles relacionados à operação do reator. Esta investigação estudou o comportamento de um ASBR de leito fixo, em escala de bancada, formado por matrizes de pedra pome, para suporte da biomassa, provido de agitador mecânico, no tratamento de esgotos sanitários coletados no Campus da USP, em São Carlos. O reator, com volume total de 7,2 L, foi operado em ciclos de 8 horas de duração, durante 86 dias, totalizando 216 ciclos. A DQO média afluente, no período, foi de 446 ± 169 mg/L, com valores médios, no efluente, respectivamente iguais a 233 ± 52, 64 ± 31, 32 ± 15 e 141 ± 32 mg/L para a DOQ total, fração particulada, coloidal e solúvel. Esses valores confirmam o bom desempenho do reator na remoção da fração particulada da matéria orgânica (eficiência de remoção de 84%). O modelo cinético para a velocidade de decaimento da DQO, que melhor se ajustou aos dados experimentais foi o de primeira ordem com residual (k1ap = 0,63 ± 0,06/h). Apesar do bom desempenho do reator, a presença, no efluente, de concentrações elevadas de sólidos solúveis fixos e valores anormais de alcalinidade e pH, alertaram para a necessidade de estudo mais aprofundado do leito, concluindo-se que a pedra pome sintética não apresenta a estabilidade química necessária para seu uso como material suporte nesse tipo de reator, pois ocorreu a perda contínua de cálcio do leito que resultou na perda da estabilidade estrutural das matrizes<br>The anaerobic sequencing batch reactors (ASBR) with immobilized biomass, that are under development at Mauá Institute of Technology and at São Carlos Engineering School, presented good performance in the wastewater treatment. Recent researches are trying to improve this reactor design and operation. The choice of the support material is one of the important aspects of this development stage, besides the knowledge enhancement of the fundamental process aspects and the ones related with the reactor operation and its influence in the performance. This work presents the results of the ASBR operation and their influence in its performance, in bench scale, filled with pumice stones matrices used as biomass support. The reactor was provided with a mechanical agitator to treat the sewage collected at USP-São Carlos. The reactor volume was 7,2 liters and was operated with 8 hours duration cycles, during 86 days, totalizing 216 cycles. The mean inflow COD was 446 ± 169 mg/L, obtaining mean values, in the effluent, respectively equal to a 233 ± 52, 64 ± 31, 32 ± 15 e 141 ± 32 mg/L for total COD, particulate fraction, colloidal fraction and soluble fraction. This data confirm the good reactor performance in the removal of the particulate fraction of the organic matter (removal efficiency of 84%). The kinetic model for the COD decay rate that best fit the experimental data was a first order model with residual (k1ap=0,63 ± 0,06 /h). Despite of the good reactor performance, the high fixed soluble solids concentration in the effluent, as the abnormal alkalinity and pH values, took the matrices study further. It was concluded that the synthetic pumice stones, does not present a chemical stability necessary for its use as support material in this kind of reactor, because the matrices continuously lost calcium, resulting in the lost of its structural stability
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Becker, Shannon. "Comparison of Ankle Kinematics between Soft and Semi-Rigid Ankle Orthoses for Field-Sport Activities." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/30297.
Full textAbstract:
Purpose of study: Examine ASO (soft) and Malleoloc semi-rigid stirrup (SRS) ankle orthosis designs on ankle kinematics during field-sport movements: sprint, one-legged jump, and 45-degree cut.
Participants: 13 competitive Ultimate players who regularly wore an ankle orthosis during physical activity.
Methods: ASO or Malleoloc orthosis was randomly assigned to each person. Kinematic data were captured while the participants performed several trials for each movement in a motion analysis laboratory. Participants repeated the protocol with the other orthosis.
Results: ASO allowed significantly more plantar-flexion during weight acceptance of the planting foot in cutting (p=0.038). In jumping, the Malleoloc allowed significantly more eversion-inversion range during stance (p=0.048) and eversion-inversion angular velocity from midstance to toe-off (p=0.026). Qualitative data also showed a significant preference for ASO.
Conclusion: Hypotheses that ankle inversion and eversion would be greater with the ASO; and plantar-flexion and dorsiflexion would be greater with the Malleoloc were refuted.
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Krings, Ulrich [Verfasser]. "[Schriftenverzeichnis: zur Habilitation vorgelegte und genehmigte Arbeiten] : [zum Thema: Metabolismus flüchtiger Stoffe in Asco- und Basidiomyceten] / Ulrich Krings." Hannover : Technische Informationsbibliothek und Universitätsbibliothek Hannover (TIB), 2011. http://d-nb.info/1017335117/34.
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Logan, Gemma. "An investigation of the role of ankyrin repeat and SOCS box proteins (ASBs) in normal and malignant haematopoiesis." Thesis, Queen's University Belfast, 2015. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.678942.
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