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1

International Symposium on Bacterial Polyhydroxyalkanoates (5th 1996 Davos, Switzerland). 1996 International Symposium on Bacterial Polyhydroxyalkanoates. Ottawa: NRC Research Press, 1997.

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2

Ross, Shari. The importance of bacterial roles in the degradation of phaeocystis polymers. Bellingham, WA: Huxley College of Environmental Studies, Western Washington University, 2000.

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3

Speicherung von Polyhydroxyfettsäuren in schwefelfreien Purpurbakterien: Charakterisierung der Polymere und der PHB-Synthese-Gene sowie Beziehung zur Photoproduktion von Wasserstoff. Göttingen: Unitext, 1992.

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4

D, Knudsen Walter, and Bruns Sam S, eds. Bacterial DNA, DNA polymerase, and DNA helicases. Hauppauge, NY: Nova Science, 2009.

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5

Turner, Helen Louise. The use of polymerase chain reaction in determining the mechanism of bacterial resistence to fluoroquinolone antibiotics. Birmingham: University of Birmingham, 1995.

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6

Vekshin, N. L. Biophysics of DNA-antibiotic complexes. Hauppauge, N.Y: Nova Science Publishers, 2010.

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7

L, Hershberger Charles, Queener Stephen W, Hegeman George, American Society for Microbiology, and ASM Conference on the Genetics and Molecular Biology of Industrial Microorganisms (4th : 1988 : Bloomington, Ind.), eds. Genetics and molecular biology of industrial microorganisms. Washington, D.C: American Society for Microbiology, 1989.

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8

Amos, Linda A., and Jan Löwe. Prokaryotic Cytoskeletons: Filamentous Protein Polymers Active in the Cytoplasm of Bacterial and Archaeal Cells. Springer, 2017.

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9

Amos, Linda A., and Jan Löwe. Prokaryotic Cytoskeletons: Filamentous Protein Polymers Active in the Cytoplasm of Bacterial and Archaeal Cells. Springer, 2018.

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10

Microbial extracellular polymeric substances: Characterization, structure, and function. Berlin: Springer, 1999.

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11

(Editor), Jost Wingender, Thomas R. Neu (Editor), and Hans-Curt Flemming (Editor), eds. Microbial Extracellular Polymeric Substances: Characterization, Structure and Function. Springer, 1999.

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12

Bensimon, David, Vincent Croquette, Jean-François Allemand, Xavier Michalet, and Terence Strick. Single-Molecule Studies of Nucleic Acids and Their Proteins. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198530923.001.0001.

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This book presents a comprehensive overview of the foundations of single-molecule studies, based on manipulation of the molecules and observation of these with fluorescent probes. It first discusses the forces present at the single-molecule scale, the methods to manipulate them, and their pros and cons. It goes on to present an introduction to single-molecule fluorescent studies based on a quantum description of absorption and emission of radiation due to Einstein. Various considerations in the study of single molecules are introduced (including signal to noise, non-radiative decay, triplet states, etc.) and some novel super-resolution methods are sketched. The elastic and dynamic properties of polymers, their relation to experiments on DNA and RNA, and the structural transitions observed in those molecules upon stretching, twisting, and unzipping are presented. The use of these single-molecule approaches for the investigation of DNA–protein interactions is highlighted via the study of DNA and RNA polymerases, helicases, and topoisomerases. Beyond the confirmation of expected mechanisms (e.g., the relaxation of DNA torsion by topoisomerases in quantized steps) and the discovery of unexpected ones (e.g., strand-switching by helicases, DNA scrunching by RNA polymerases, and chiral discrimination by bacterial topoII), these approaches have also fostered novel (third generation) sequencing technologies.
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13

Solomon, Tom. Meningitis. Oxford University Press, 2011. http://dx.doi.org/10.1093/med/9780198569381.003.0969.

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Meningitis is defined as inflammation of the brain meninges, characterized clinically by inflammatory cells in CSF. When there is concurrent parenchymal brain involvement the term meningoencephalitis is used, meningoencephalomyelitis implies that there is spinal cord involvement too.Although increased cellularity in the CSF, or pleocytosis, is traditionally considered the hallmark of meningitis, some organisms, particularly fungi, can cause meningitis without a pleocytosis, especially in the immunocompromised. The advent of more sensitive methods of detecting viral nucleic acid in the CSF such as the polymerase chain reaction, have also shown that viral central nervous system infection can occur without an associated pleocytosis. When none of the common bacterial agents is easily identified the term aseptic meningitis is often used. The majority of such cases are caused by viruses; non-viral causes of an aseptic meningitis picture include certain bacteria which are not readily cultured, and do not grow in standard culture media, such as Borrelia burgdorferi. The clinical presentations of meningitis can be broadly divided into the acute, recurrent, and chronic. The development of meningitis depends on the infecting organism, and also whether there is any particular host susceptibility.
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14

Lai, Kar Neng, and Sydney C. W. Tang. Immunoglobulin A nephropathy. Edited by Neil Turner. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199592548.003.0069_update_001.

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A working hypothesis is that patients with immunoglobulin A (IgA) nephropathy have inherited defects in B cells producing galactose-deficient polymeric IgA1. Additional cofactors are required to form immune complexes and their deposition in glomeruli. Molecular characterization of IgG autoantibodies that recognize abnormally underglycosylated IgA1 reveals a specific amino acid substitution in the variable region of the IgG1 heavy chain. This substitution greatly enhances IgG1 binding to the galactose-deficient IgA1. The triggering antigens may include viral or bacterial antigens, or possibly by ingested food epitopes. Antiglycan IgG1 antibodies are one of the additional risk factors, or a second/multiple hit, which predisposes to disease development.
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15

Greenlee, John E. Cerebrospinal Fluid. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199937837.003.0145.

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Evaluation of cerebrospinal fluid is of essential importance in the diagnosis of central nervous system infections, with a major role in the diagnosis of meningitis and encephalitis. In bacterial and viral meningitis, CSF evaluation is usually straightforward, and well-defined serological and molecular techniques are available for CSF examination in many of the more common viral encephalitides. This is in contrast to CSF evaluation in cases of tuberculous and chronic meningitis, in which organisms may be difficult to detect by culture or polymerase chain methods or antigen detection. This chapter first discusses the anatomy and physiology of CSF production, reviews concepts of CSF analysis, and then reviews CSF changes in the major categories of central nervous system infections.
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16

Kirchman, David L. Elements, biochemicals, and structures of microbes. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198789406.003.0002.

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Microbiologists focus on the basic biochemical make-up of microbes, such as relative amounts of protein, RNA, and DNA in cells, while ecologists and biogeochemists use elemental ratios, most notably, the ratio of carbon to nitrogen (C:N), to explore biogeochemical processes and to connect up the carbon cycle with the cycle of other elements. Microbial ecologists make use of both types of data and approaches. This chapter combines both and reviews all things, from elements to macromolecular structures, that make up bacteria and other microbes. The most commonly used elemental ratio was discovered by Alfred Redfield who concluded that microbes have a huge impact on the chemistry of the oceans because of the similarity in nitrogen-to-phosphorus ratios for organisms and nitrate-to-phosphate ratios in the deep oceans. Although statistically different, the C:N ratios in soil microbes are remarkably similar to the ratios of aquatic microbes. The chapter moves on to discussing the macromolecular composition of bacteria and other microbes. This composition gives insights into the growth state of microbes in nature. Geochemists use specific compounds, “biomarkers”, to trace sources of organic material in ecosystems. The last section of the chapter is a review of extracellular polymers, pili, and flagella, which serve a variety of functions, from propelling microbes around to keeping them stuck in one place.
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17

Vigdor, Steven E. Randomness and Complexity. Oxford University Press, 2018. http://dx.doi.org/10.1093/oso/9780198814825.003.0007.

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Chapter 7 describes the fundamental role of randomness in quantum mechanics, in generating the first biomolecules, and in biological evolution. Experiments testing the Einstein–Podolsky–Rosen paradox have demonstrated, via Bell’s inequalities, that no local hidden variable theory can provide a viable alternative to quantum mechanics, with its fundamental randomness built in. Randomness presumably plays an equally important role in the chemical assembly of a wide array of polymer molecules to be sampled for their ability to store genetic information and self-replicate, fueling the sort of abiogenesis assumed in the RNA world hypothesis of life’s beginnings. Evidence for random mutations in biological evolution, microevolution of both bacteria and antibodies and macroevolution of the species, is briefly reviewed. The importance of natural selection in guiding the adaptation of species to changing environments is emphasized. A speculative role of cosmological natural selection for black-hole fecundity in the evolution of universes is discussed.
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18

Specter, Steven, Herman Friedman, and Mauro Bendinelli. Rapid Detection of Infectious Agents. Springer, 2013.

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19

Steven, Specter, Bendinelli Mauro, and Friedman Herman 1931-, eds. Rapid detection of infectious agents. New York: Plenum Press, 1998.

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20

Specter, Steven. Rapid Detection of Infectious Agents. Springer, 2013.

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21

Specter, Steven, Herman Friedman, and Mauro Bendinelli. Rapid Detection of Infectious Agents. Springer London, Limited, 2006.

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22

Pcr Protocols for Emerging Infectious Diseases A Supplement to Diagnostic Molecular Microbiology: Principles and Applications. ASM Press, 1996.

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23

H, Persing David, ed. PCR protocols for emerging infectious diseases: A supplement to Diagnostic Molecular Microbiology : principles and applications. Washington, D.C: ASM Press, 1996.

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