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Journal articles on the topic 'Benzohydrazides'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Alqahtani, Yahya S., Sravanthi Avunoori, Vaibhavi M. Kanimehalli, et al. "Synthesis, Docking Studies, and Biological Evaluation of Some New Pyrrolyl Benzohydrazide Derivatives." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 01 (2024): 35. http://dx.doi.org/10.59467/ijhc.2024.34.35.

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A series of 16 new N-(2-(4-(1H-pyrrol-1-yl)phenoxy)acetyl)-N-substituted benzohydrazides was synthesized by the reaction of 1-(1H-pyrrol-1-yl)benzohydrazide with substituted benzoic acids in the presence of N,N-dimethylformamide, HBTU, and DIEA. Molecular docking and biological screening were done on the synthesized compounds to conduct antitubercular and antibacterial activity tests. The selected compounds were investigated for the inhibition of the InhA and DHFR enzymes. Promising antitubercular, antibacterial, and enzyme inhibitory action has been shown for all molecules. Absorption, distri

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2

Manikandan, V., S. Balaji, R. Senbagam, et al. "Synthesis and antimicrobial activities of some (E)-N'-1-(substituted benzylidene)benzohydrazides." International Journal of Advanced Chemistry 5, no. 1 (2017): 17. http://dx.doi.org/10.14419/ijac.v5i1.7155.

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About ten substituted (E)-N'-1-(substituted benzylidene) benzohydrazides have been synthesized. They are analyzed by their analytical, ultra violet (UV), Fourier transform-IR (FT-IR) and nuclear magnetic resonance (NMR) spectral data and evaluated by antimicrobial activities such antibacterial and antifungal activities.

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3

Meshcheryakova, A. A., K. S. Neumoina, and V. V. Sorokin. "Three-Component Synthesis of Spiropyrazolines Derived from Benzohydrazides." Russian Journal of Organic Chemistry 59, no. 8 (2023): 1309–14. http://dx.doi.org/10.1134/s1070428023080031.

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4

Soundarajan, Kamalakannan, Rathinam Periyasamy, and Thangamuthu Mohan Das. "Design and synthesis of sugar-benzohydrazides: low molecular weight organogelators." RSC Advances 6, no. 85 (2016): 81838–46. http://dx.doi.org/10.1039/c6ra18715c.

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A novel class of methyltriglycol benzohydrazide based N-glycosylamines containing long alkyl chain derivatives were synthesized in good yield and characterized using NMR (<sup>1</sup>H and <sup>13</sup>C) spectral analysis.

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5

Zhou, Yi-Xuan, Wei Li, and Zhonglu You. "Synthesis, Spectroscopic Characterization, Crystal Structures and Antibacterial Activity of Benzohydrazones Derived from 4-Pyridinecarboxaldehyde with Various Benzohydrazides." Acta Chimica Slovenica 70, no. 2 (2023): 240–46. http://dx.doi.org/10.17344/acsi.2023.8123.

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Reaction of 4-pyridinecarboxaldehyde with 3-hydroxy-4-methoxybenzohydrazide, 4-bromobenzohydrazide and 4-dimethylaminobenzohydrazide, respectively in methanol afforded three new benzohydrazones. They are 3-hydroxy-4-methoxy-N’-(pyridin-4-ylmethylene)benzohydrazide (1), 4-bromo-N’-(pyridin-4-ylmethylene)benzohydrazide (2), and 4-(dimethylamino)-N’-(pyridin-4-ylmethylene)benzohydrazide (3). The compounds have been characterized by elemental analysis, 1H and 13C NMR and IR spectroscopy, as well as single crystal X-ray diffraction. The antibacterial activities of the compounds against E. coli, P.

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6

Geffken, Detlef, and Maria Anna Köllner. "Cyclisierung von N′,N′-disubstituierten Anthranilsäurehydraziden mit 1,1′-Oxalyldiimidazol zu 4-Amino-2,3,4,5-tetrahydro-1H-1,4-benzodiaz- epin-2,3,5-trionen / Cyclization of N’,N’-Disubstituted Anthranilic Hydrazides with 1,1’-Oxalyldiimidazole to 4-Amino-2,3,4,5-tetrahydro-1H-1,4-benzodiazepin-2,3,5-triones." Zeitschrift für Naturforschung B 60, no. 11 (2005): 1207–11. http://dx.doi.org/10.1515/znb-2005-1115.

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N’,N’-Disubstituted (2-phenylamino)-, (2-methylamino)- and (2-benzylamino)benzohydrazides (1) are cyclized by in situ prepared 1,1’-oxalyldiimidazole to give 3-amino-2,3,4,5-tetrahydro-1H- 1,4-benzodiazepine-2,3,5-triones 2 as the major product. Depending on the substituents of 1 competitive formation of quinazoline-2,4-diones 3 and 1,3,4-oxadiazoline-2-one 4 is observed. The formation of heterocycles 2, 3, 4 is rationalized via a common primary intermediate 1A.

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7

Mahnashi, Mater H., Sravanthi Avunoori, Sanjay Gopi, et al. "Synthesis, molecular docking study and biological evaluation of new pyrrole scaffolds as potential antitubercular agents for dual targeting of enoyl ACP reductase and dihydrofolate reductase." PLOS ONE 19, no. 5 (2024): e0303173. http://dx.doi.org/10.1371/journal.pone.0303173.

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In this study, new series of N’-(2-(substitutedphenoxy)acetyl)-4-(1H-pyrrol-1-yl)benzohydrazides (3a-j) 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N’-(2-(substitutedphenoxy)acetyl)benzohydrazides (5a-j) were synthesized, characterized and assessed as inhibitors of enoyl ACP reductase and DHFR. Most of the compounds exhibited dual inhibition against the enzymes enoyl ACP reductase and DHFR. Several synthesized substances also demonstrated significant antibacterial and antitubercular properties. A molecular docking analysis was conducted in order to determine the potential mechanism of action of the synthe

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8

Krátký, Martin, Šárka Štěpánková, Michaela Brablíková, Katarína Svrčková, Markéta Švarcová, and Jarmila Vinšová. "Novel Iodinated Hydrazide-hydrazones and their Analogues as Acetyl- and Butyrylcholinesterase Inhibitors." Current Topics in Medicinal Chemistry 20, no. 23 (2020): 2106–17. http://dx.doi.org/10.2174/1568026620666200819155503.

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Background: Hydrazide-hydrazones have been known as scaffold with various biological activities including inhibition of acetyl- (AChE) and butyrylcholinesterase (BuChE). Cholinesterase inhibitors are mainstays of dementias’ treatment. Objective: Twenty-five iodinated hydrazide-hydrazones and their analogues were designed as potential central AChE and BuChE inhibitors. Methods: Hydrazide-hydrazones were synthesized from 4-substituted benzohydrazides and 2-/4- hydroxy-3,5-diiodobenzaldehydes. The compounds were investigated in vitro for their potency to inhibit AChE from electric eel and BuChE f

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9

Taghavi, Ali, Samir Nasir, Marcus Pickhardt, et al. "N′-Benzylidene-Benzohydrazides as Novel and Selective Tau-PHF Ligands." Journal of Alzheimer's Disease 27, no. 4 (2011): 835–43. http://dx.doi.org/10.3233/jad-2011-111238.

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10

Çapan, İrfan. "Synthesis of carbazole-based acetyl benzohydrazides targeting urease enzyme inhibition." Organic Communications, no. 2 (August 18, 2021): 1–10. http://dx.doi.org/10.25135/acg.oc.109.2107.2140.

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11

Reino, José L., Liane Saiz-Urra, Rosario Hernández-Galán, et al. "Quantitative Structure−Antifungal Activity Relationships of Some Benzohydrazides againstBotrytis cinerea." Journal of Agricultural and Food Chemistry 55, no. 13 (2007): 5171–79. http://dx.doi.org/10.1021/jf0704211.

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12

Josephine, J. Lesy, T. Pazhanisamy, M. Suresh, et al. "SPECTRAL AND BIOLOGICAL ACTIVITIES OF TiO2 MEDIATED SYNTHESIS OF BENZOHYDRAZIDES." RASAYAN Journal of Chemistry 18, no. 01 (2025): 501–7. https://doi.org/10.31788/rjc.2025.1819041.

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The sol-gel method was used to synthesize TiO₂ nanoparticles, which were then characterized by powder XRD, SEM, EDS, and spectroscopy. The benzohydrazide derivatives (1-4) were synthesized utilizing sol-gel-produced TiO₂ (R) as a catalyst in a solvent environment and characterized by FT-IR, NMR, and mass spectrum analyses. Antimicrobial tests were conducted against bacterial strains such as E. coli, S. typhi, S. aureus and P. aeruginosa, as well as fungal strains such as C. albicans, A. niger, Mucor and Rhizopus sp.

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13

Nikiforova, E. A., R. R. Makhmudov, D. P. Zverev, M. V. Dmitriev, S. N. Shurov, and N. F. Kirillov. "Synthesis and analgesic activity of <i>N</i>-(1-aryl-3-oxo-2-azaspiro[3.5]nonan-2-yl)benzamides." Журнал общей химии 93, no. 8 (2023): 1162–72. http://dx.doi.org/10.31857/s0044460x23080024.

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The Reformatsky reagent, derived from the methyl 1-bromocyclohexanecarboxylate and zinc, reacts with N′ -(arylmethylidene)benzohydrazides, to form, as a result of intramolecular cyclization of the initial addition products, N -(1-aryl-3-oxo-2-azaspiro[3.5]nonan-2-yl)benzamides. The structure of the latter was proved by X-ray diffraction analysis. In the case of p -tolualdehyde benzoylhydrazone, the adduct of the Reformatsky reagent to the double carbon-nitrogen bond of the substrate, which not underwent cyclization, was predominantly isolated. The resulting spiroazetidin-2-ones exhibit antinoc

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14

Garberová, Monika, Ivan Potočňák, Monika Tvrdoňová, et al. "Spectral, structural, and pharmacological studies of perillaldehyde and myrtenal based benzohydrazides." Journal of Molecular Structure 1271 (January 2023): 134112. http://dx.doi.org/10.1016/j.molstruc.2022.134112.

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15

Sokolova, K. V., V. V. Stavytskyi, S. О. Konovalova, O. A. Podpletnya, S. I. Kovalenko, and A. P. Avdeenko. "Design and search for prospective diuretics (CA II Inhibitors) among aroylhydrazones of esters quinone oxime using in silico and in vivo methodology." Medicni perspektivi 27, no. 4 (2022): 27–37. http://dx.doi.org/10.26641/2307-0404.2022.4.271120.

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The design and search for new selective inhibitors of CA II with a better pharmacological profile, which would cause minimal electrolyte disturbances in the body, remains an urgent problem of medical chemistry and pharmacology today. It is important that the discovered new classes of inhibitors do not always contain the main “pharmacophoric” function (sulfamide), which is characteristic of “classic” drugs (Acetazolamide, Methazolamide, Ethoxzolamide, Dorzolamide and others), but are derivatives of phenols, polyamines, coumarins/thiocoumarins, ureas, thioureas, hydroxamates, etc. These molecule

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16

Lee, Kwanghee, Young-Ah Kim, Chanhyun Jung, et al. "Microwave-Mediated, Catalyst-Free Synthesis of 1,2,4-Triazolo[1,5-a]pyridines from Enaminonitriles." Molecules 29, no. 4 (2024): 894. http://dx.doi.org/10.3390/molecules29040894.

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A catalyst-free, additive-free, and eco-friendly method for synthesizing 1,2,4-triazolo[1,5-a]pyridines under microwave conditions has been established. This tandem reaction involves the use of enaminonitriles and benzohydrazides, a transamidation mechanism followed by nucleophilic addition with nitrile, and subsequent condensation to yield the target compound in a short reaction time. The methodology demonstrates a broad substrate scope and good functional group tolerance, resulting in the formation of products in good-to-excellent yields. Furthermore, the scale-up reaction and late-stage fun

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17

Mercy A., Ezeokonkwo, Onwosi Ekene L., Odimegwu Damian C., et al. "Novel Butan-2-ylidene Benzohydrazides; Synthesis, Antimicrobial Evaluation and Molecular Docking Study." International Journal of Sciences 10, no. 02 (2021): 13–21. http://dx.doi.org/10.18483/ijsci.2420.

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18

Wardell, Solange M. S. V., Thatyana R. A. Vasconcelos, Marcus V. N. de Souza, James L. Wardell, John N. Low, and Christopher Glidewell. "Four substituted benzohydrazides: hydrogen-bonded structures in one, two and three dimensions." Acta Crystallographica Section C Crystal Structure Communications 62, no. 10 (2006): o618—o624. http://dx.doi.org/10.1107/s0108270106034974.

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19

VARAPRASADU, B. DURGA, K. SHIVA KUMAR, and B. PULLA RAO. "Design, Synthesis, Characterization and Antibacterial Activity of Some Novel Furan Supported 1,2,4-Triazoles." Asian Journal of Chemistry 35, no. 10 (2023): 2493–97. http://dx.doi.org/10.14233/ajchem.2023.27959.

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A methodical approach to synthesize several novel 2-phenyl-4-methylfuran [2,3-e][1,2,4]triazolo [1,5-c]pyrimidine derivatives (5a-c) as final compounds, N-(4-imino-4-methylfuro [2,3-d]pyrimidin-3(4H)-ylbenzamides (4a-c) by involving 2-amino-3-cyano-4-methyl furan (1) and N-(3-cyano-4-methylfuran)formimidic ethyl ether (2) and N’-((Z-(3-cyano-4-methylfuran-2-ylimino)methyl)benzohydrazides (3a-c) as intermediates and their antibacterial activity was tested. The chemical structures of all the newly synthesized intermediates and title compounds have been characterized by 1H NMR, IR, HRMS and eleme

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20

Sokolova, K.V., V.V. Stavytskyi, S.О. Konovalova, O.A. Podpletnya, S.I. Kovalenko, and A.P. Avdeenko. "Design and search for prospective diuretics (CA II Inhibitors) among aroylhydrazones of esters quinone oxime using in silico and in vivo methodology." Medicni perspektivi 27, no. 4 (2022): 27–37. https://doi.org/10.26641/2307-0404.2022.4.271120.

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The design and search for new selective inhibitors of CA II with a better pharmacological profile, which would cause minimal electrolyte disturbances in the body, remains an urgent problem of medical chemistry and pharmacology today. It is important that the discovered new classes of inhibitors do not always contain the main “pharmacophoric” function (sulfamide), which is characteristic of “classic” drugs (Acetazolamide, Methazolamide, Ethoxzolamide, Dorzolamide and others), but are derivatives of phenols, polyamines, coumarins/thiocoumarins, ureas, thioureas, hydr

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21

Katiyar, Arpit, Mahesh Hegde, Sujeet Kumar, et al. "Synthesis and evaluation of the biological activity of N′-[2-oxo-1,2 dihydro-3H-indol-3-ylidene] benzohydrazides as potential anticancer agents." RSC Advances 5, no. 56 (2015): 45492–501. http://dx.doi.org/10.1039/c5ra01528f.

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New N′-[2-oxo-1,2-dihydro-3H-indol-3-ylidene]benzohydrazide derivatives were synthesized and evaluated for their cytotoxic properties against murine leukemia, L1210, human leukemia, REH, K562 and CEM and human cervix carcinoma, HeLa cells.

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22

Kuznetsov, V. V., L. M. Skibina, and R. R. Khalikov. "Effect of the structure of benzohydrazides on cadmium electrodeposition from perchlorate and iodide electrolytes." Protection of Metals 42, no. 6 (2006): 570–76. http://dx.doi.org/10.1134/s0033173206060087.

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23

Osyanin, V. A., P. P. Purygin, and Z. P. Belousova. "Synthesis of 4-(1H-Azol-1-ylmethyl)benzohydrazides and Their Acyclic and Heterocyclic Derivatives." Russian Journal of General Chemistry 75, no. 1 (2005): 111–17. http://dx.doi.org/10.1007/s11176-005-0180-7.

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24

Raparti, Vyankatesh, Trupti Chitre, Kailas Bothara, et al. "Novel 4-(morpholin-4-yl)-N′-(arylidene)benzohydrazides: Synthesis, antimycobacterial activity and QSAR investigations." European Journal of Medicinal Chemistry 44, no. 10 (2009): 3954–60. http://dx.doi.org/10.1016/j.ejmech.2009.04.023.

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25

Houngbedji, Neto-Honorius, Šárka Štěpánková, Václav Pflégr, et al. "Novel Inhibitors of Acetyl- and Butyrylcholinesterase Derived from Benzohydrazides: Synthesis, Evaluation and Docking Study." Pharmaceuticals 16, no. 2 (2023): 172. http://dx.doi.org/10.3390/ph16020172.

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On the basis of previous reports, novel 2-benzoylhydrazine-1-carboxamides were designed as potential inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). Inhibitors of these enzymes have many clinical applications. 2-(Substituted benzoyl)hydrazine-1-carboxamides decorated with N-methyl or tridecyl were prepared with three methods from commercially available or self-prepared hydrazides and isocyanates. For methyl derivatives, N-succinimidyl N-methylcarbamate was used or methyl isocyanate was prepared via Curtius rearrangement. Tridecyl isocyanate was synthesized again via

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26

Mahnashi, Mater H., Pooja Koganole, Prem Kumar S. R., et al. "Synthesis, Molecular Docking Study, and Biological Evaluation of New 4-(2,5-Dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl)benzohydrazides as Dual Enoyl ACP Reductase and DHFR Enzyme Inhibitors." Antibiotics 12, no. 4 (2023): 763. http://dx.doi.org/10.3390/antibiotics12040763.

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In this study, a new series of 4-(2,5-dimethyl-1H-pyrrol-1-yl)-N’-(2-(substituted)acetyl) benzohydrazides (5a–n) were prepared and new heterocycles underwent thorough characterization and evaluation for antibacterial activity; some of them underwent further testing for in vitro inhibition of enoyl ACP reductase and DHFR enzymes. The majority of the synthesized molecules exhibited appreciable action against DHFR and enoyl ACP reductase enzymes. Some of the synthesized compounds also showed strong antibacterial and antitubercular properties. In order to determine the potential mode of action of

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27

Manikandan, Venkatesan, Selvaraj Balaji, Rajamohan Senbagam, et al. "Synthesis, spectral LFER and antimicrobial activities of some (E)-N׳-(1-(substituted phenyl)ethylidene)benzohydrazides." Annales Universitatis Mariae Curie-Sklodowska, sectio AA – Chemia 71, no. 2 (2017): 29. http://dx.doi.org/10.17951/aa.2016.71.2.29.

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<p class="IEEEAuthorAffiliation">About eleven substituted (<em>E</em>)-<em>N</em><em>׳</em>-(1-(substituted phenyl) ethylidene) benzo- hydrazides have been synthesized. They are characterized by their analytical, ultraviolet, infrared and NMR spectral data. The antibacterial and fungal activities of these chalcones have been evaluated.</p>

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28

Rao, A. R. Balavardhana, та Samudranil Pal. "Mono- and dinuclear platinum(II) complexes via single and double cycloplatinations of Nʹ-(arylidene)benzohydrazides". Journal of Organometallic Chemistry 797 (листопад 2015): 96–100. http://dx.doi.org/10.1016/j.jorganchem.2015.08.003.

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29

Jha, Ajit Kumar, Rajkiran Kumari, and Srinivasan Easwar. "A Hydrazine Insertion Route to N′-Alkyl Benzohydrazides by an Unexpected Carbon–Carbon Bond Cleavage." Organic Letters 21, no. 20 (2019): 8191–95. http://dx.doi.org/10.1021/acs.orglett.9b02657.

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30

Atovmyan, E. G., S. M. Aldoshin, and L. O. Atovmyan. "Structural Features of Crystalline Hydrates of N'-Substituted Benzohydrazides and their Reflection in IR-Spectra." Molecular Crystals and Liquid Crystals Incorporating Nonlinear Optics 178, no. 1 (1990): 231–44. http://dx.doi.org/10.1080/00268949008042721.

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31

Gaile, Anastasija, Sergey Belyakov, Ramona Dūrena, Ņikita Griščenko, Anzelms Zukuls та Nelli Batenko. "Studies of the Functionalized α-Hydroxy-p-Quinone Imine Derivatives Stabilized by Intramolecular Hydrogen Bond". Molecules 29, № 7 (2024): 1613. http://dx.doi.org/10.3390/molecules29071613.

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In this work, reactions between 6,7-dichloropyrido[1,2-a]benzimidazole-8,9-diones with different benzohydrazides were studied. Nucleophilic substitution at C(6) was followed by isomerization and led to α-hydroxy-p-quinone imine derivatives. Synthesized compounds represent a combination of several structural motifs: a benzimidazole core fused with α-hydroxy-p-quinone imine, which contains a benzamide fragment. X-ray crystallography analysis revealed the formation of dimers linked through OH···O interactions and stabilization of the imine form by strong intramolecular NH···N hydrogen bonds. The

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32

Sorna, Venkataswamy, Emily R. Theisen, Bret Stephens, et al. "High-Throughput Virtual Screening Identifies NovelN′-(1-Phenylethylidene)-benzohydrazides as Potent, Specific, and Reversible LSD1 Inhibitors." Journal of Medicinal Chemistry 56, no. 23 (2013): 9496–508. http://dx.doi.org/10.1021/jm400870h.

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33

Liu, Jia-Xue, Shi-Yu Zhang, Meng-Xiao Tai, Wei Li, and Zhonglu You. "Synthesis, Characterization and X-Ray Crystal Structures of Aroylhydrazones Derived from 2-Chlorobenzaldehyde with Various Benzohydrazides." Acta Chimica Slovenica 71, no. 4 (2024): 587–94. https://doi.org/10.17344/acsi.2024.8967.

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Reaction of 2-chlorobenzaldehyde with 3-trifluoromethylbenzohydrazide, 3,5-dimethoxybenzohydrazide, 4-trifluoromethylbenzohydrazide and 2-bromobenzohydrazide, respectively, in methanol afforded four new aroylhydrazones. The newly synthesized compounds were characterized by means of elemental analysis, IR and 1H NMR spectroscopy, and their structures were further confirmed by X-ray single crystal determination. The compounds were assayed for their antibacterial activities against E. coli, P. aeruginosa, B. subtilis, and S. aureus and show interesting results.

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34

Babu, G. Narendra, and Samudranil Pal. "Mono- and dinuclear palladium(II) cyclometallates with 4-R-N'-(mesitylidene)benzohydrazides and mono- and diphosphines." Journal of Organometallic Chemistry 805 (March 2016): 19–26. http://dx.doi.org/10.1016/j.jorganchem.2016.01.003.

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35

Simijonović, Dušica M., Dejan A. Milenković, Edina H. Avdović, et al. "Coumarin N-Acylhydrazone Derivatives: Green Synthesis and Antioxidant Potential—Experimental and Theoretical Study." Antioxidants 12, no. 10 (2023): 1858. http://dx.doi.org/10.3390/antiox12101858.

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Coumarin N-acylhydrazone derivatives were synthesized in the reaction of 3-acetylcoumarin and different benzohydrazides in the presence of molecular iodine as catalyst and at room temperature. All reactions were rapidly completed, and products were obtained in good to excellent yields. It is important to emphasize that four products were reported for the first time in this study. The obtained compounds were subjected to evaluation of their in vitro antioxidative activity using DPPH, ABTS, and FRAP methods. It was shown that products with a catechol moiety in their structure are the most potent

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36

Grande, Fedora, Ines Barone, Francesca Aiello, et al. "Identification of novel 2-(1H-indol-1-yl)-benzohydrazides CXCR4 ligands impairing breast cancer growth and motility." Future Medicinal Chemistry 8, no. 2 (2016): 93–106. http://dx.doi.org/10.4155/fmc.15.176.

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37

Kumar, Pradeep, Balasubramanian Narasimhan, Kalavathy Ramasamy, et al. "N′-[4-[(Substituted imino)methyl]benzylidene]-substituted benzohydrazides: synthesis, antimicrobial, antiviral, and anticancer evaluation, and QSAR studies." Monatshefte für Chemie - Chemical Monthly 144, no. 6 (2012): 825–49. http://dx.doi.org/10.1007/s00706-012-0877-3.

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38

Madhira, Sravanthi, Kiranmai Mandava, Sarangapani Manda, Sai Prasanna R, and Vijayalaxmi T. "Synthesis and Evaluation of Some Novel N, NDialkylaminoalkoxy-2-Oxo-Indole-3-Ylidene Benzohydrazides as Anticonvulsant Agents." IOSR Journal of Pharmacy and Biological Sciences 12, no. 02 (2017): 84–93. http://dx.doi.org/10.9790/3008-1202028493.

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39

Kumar, Pradeep, Balasubramanian Narasimhan, Kalavathy Ramasamy, Vasudevan Mani, Rakesh Kumar Mishra, and Abu Bakar Abdul Majeed. "Synthesis, antimicrobial, anticancer evaluation and QSAR studies of 2/3-bromo-N′-(substituted benzylidene/3-phenylallylidene)benzohydrazides." Arabian Journal of Chemistry 10 (May 2017): S3740—S3748. http://dx.doi.org/10.1016/j.arabjc.2014.05.010.

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40

Saini, Mahak, Pradeep Kumar, Mahesh Kumar, et al. "Synthesis, in vitro antimicrobial, anticancer evaluation and QSAR studies of N′-(substituted)-4-(butan-2-lideneamino)benzohydrazides." Arabian Journal of Chemistry 7, no. 4 (2014): 448–60. http://dx.doi.org/10.1016/j.arabjc.2013.05.010.

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Barnish, Ian T., Shing C. Fung, Martin S. Gibson, Saeed R. Khan, Gordon A. Pawalchak, and Kin M. Tse. "Benzohydrazides, benzothiohydrazides, and benzamidrazones as sources of 1,3,4(2H)-oxadiazolenones, 1,3,4(2H)-thiadiazolenones, and 1,2,4(5H)-triazolenones." Journal of Heterocyclic Chemistry 23, no. 2 (1986): 417–19. http://dx.doi.org/10.1002/jhet.5570230221.

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Saidugari, Swamy, V. Lakshmana Rao, K. Vidya, B. Ram, and B. Balram. "Synthesis of Novel Benzohydrazides Bearing 4-[3-Methyl-4-(methylsulfonyl)pyridin-2-yl] Moiety as Potential Antibacterial Agents." Asian Journal of Chemistry 28, no. 3 (2016): 639–43. http://dx.doi.org/10.14233/ajchem.2016.19448.

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Zhou, Yang, Yan Li, Wen-Jing Wang, et al. "Synthesis and biological evaluation of novel (E)-N′-(2,3-dihydro-1H-inden-1-ylidene) benzohydrazides as potent LSD1 inhibitors." Bioorganic & Medicinal Chemistry Letters 26, no. 18 (2016): 4552–57. http://dx.doi.org/10.1016/j.bmcl.2015.06.054.

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Kankanala, Kavitha, V. Ranga Reddy, Yumnam Priyadarshini Devi, et al. "Nonsteroidal Anti-inflammatory Drug-basedN-Allylidene Benzohydrazides and 1-Acyl-2-pyrazolines: Their Synthesis as Potential Cytotoxic AgentsIn Vitro." Journal of Heterocyclic Chemistry 52, no. 1 (2014): 105–13. http://dx.doi.org/10.1002/jhet.1993.

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Kumar, Pradeep, Balasubramanian Narasimhan, Kalavathy Ramasamy, et al. "ChemInform Abstract: N′-[4-[(Substituted imino)methyl]benzylidene]-substituted Benzohydrazides: Synthesis, Antimicrobial, Antiviral, and Anticancer Evaluation, and QSAR Studies." ChemInform 44, no. 34 (2013): no. http://dx.doi.org/10.1002/chin.201334055.

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Ergeç, Nedime, Sevim Rollas, and Yalçin Topalo??lu. "Studies on Azopyrazole Derivatives, VI1). Synthesis and Characterization of New 4-(1-Phenyl-3,5-dimethylpyrazolylazo)-N2-(substituted benzylidene) benzohydrazides." Archiv der Pharmazie 319, no. 6 (1986): 545–49. http://dx.doi.org/10.1002/ardp.19863190612.

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Radwan, Awwad A., F. Al-Mohanna, Fares K. Alanazi, P. S. Manogaran та Abdullah Al-Dhfyan. "Target β-catenin/CD44/Nanog axis in colon cancer cells by certain N′-(2-oxoindolin-3-ylidene)-2-(benzyloxy)benzohydrazides". Bioorganic & Medicinal Chemistry Letters 26, № 7 (2016): 1664–70. http://dx.doi.org/10.1016/j.bmcl.2016.02.064.

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Guo, Shenghai, Jianhui Zhai, and Xuesen Fan. "An I2-mediated cascade reaction of 2′-bromoacetophenones with benzohydrazides/benzamides leading to quinazolino[3,2-b]cinnoline or tryptanthrin derivatives." Organic & Biomolecular Chemistry 15, no. 6 (2017): 1521–29. http://dx.doi.org/10.1039/c6ob02699k.

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Vilková, Mária, Monika Hudáčová, Nikola Palušeková, et al. "Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties." Molecules 27, no. 9 (2022): 2883. http://dx.doi.org/10.3390/molecules27092883.

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Abstract:

A series of novel acridine N-acylhydrazone derivatives have been synthesized as potential topoisomerase I/II inhibitors, and their binding (calf thymus DNA—ctDNA and human serum albumin—HSA) and biological activities as potential anticancer agents on proliferation of A549 and CCD-18Co have been evaluated. The acridine-DNA complex 3b (-F) displayed the highest Kb value (Kb = 3.18 × 103 M−1). The HSA-derivatives interactions were studied by fluorescence quenching spectra. This method was used for the calculation of characteristic binding parameters. In the presence of warfarin, the binding const

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Riza, Hafrizal, and Jordi Buannata. "PENGARUH GUGUS FUNGSI CINCIN PIRIDIN, BENZEN, DAN ATOM NITROGEN PADA CINCIN PIRIDIN TERHADAP PENURUNAN KADAR PLASMA PIRIDOKSIN TIKUS WISTAR." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 7, no. 2 (2022): 223–31. http://dx.doi.org/10.36387/jiis.v7i2.873.

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Abstract:

In this study, researchers will conduct further studies to determine the map of functional groups that have an affinity for neuropathy-causing enzymes in the pyridine ring functional group after previous research on pyridine ring substituents. Through this study, it will be known whether there is an effect of the N atom on the pyridine ring, and the structure of the benzene ring. Therefore, the three structures, namely benzohydrazide, butyrohydrazide, formohydrazide, and isoniazid control, will be tested for their effect on the inhibition of the pyridoxal phosphokinase enzyme in experimental r

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