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Journal articles on the topic 'Bibenzyls'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Xiong, Rui-Lin, Jiao-Zhen Zhang, Xin-Yan Liu, et al. "Identification and Characterization of Two Bibenzyl Glycosyltransferases from the Liverwort Marchantia polymorpha." Antioxidants 11, no. 4 (2022): 735. http://dx.doi.org/10.3390/antiox11040735.

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Liverworts are rich in bibenzyls and related O-glycosides, which show antioxidant activity. However, glycosyltransferases that catalyze the glycosylation of bibenzyls have not yet been characterized. Here, we identified two bibenzyl UDP-glucosyltransferases named MpUGT737B1 and MpUGT741A1 from the model liverwort Marchantia polymorpha. The in vitro enzymatic assay revealed that MpUGT741A1 specifically accepted the bibenzyl lunularin as substrate. MpUGT737B1 could accept bibenzyls, dihydrochalcone and phenylpropanoids as substrates, and could convert phloretin to phloretin-4-O-glucoside and phl

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2

Rukoyatkina, Natalia, Tatyana Sokolova, Nikita Pronin, Andrei Whaley, Anastasiia O. Whaley, and Stepan Gambaryan. "Death of Leukemia Cells and Platelets Induced by 3,3′-Dihydroxy-4,5-Dimethoxybibenzyl Is Mediated by p38 Mitogen-Activated Protein Kinase Pathway." Molecules 30, no. 14 (2025): 2965. https://doi.org/10.3390/molecules30142965.

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Bibenzyls are now recognized as compounds for use in cancer therapy, and many molecules from the bibenzyl group have shown promising anticancer activity; therefore, the characterization of new bibenzyls with strong biological activity is important for developing new anticancer drugs. In this study, we compared the effects of three bibenzyls (3,3′-dihydroxy-4,5-dimethoxybibenzyl, 3,5-dihydroxy-4-methoxybibenzyl and 3,5,3′-trihydroxy-4-methoxybibenzyl) isolated from Empetrum nigrum and erianin on platelets and the MOLT-3 T-lymphoblast cell line. Among the studied bibenzyls, 3,3′-dihydroxy-4,5-di

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3

Chen, Yan, Yu Wang, Chongjun Liang, et al. "Characterization of the Key Bibenzyl Synthase in Dendrobium sinense." International Journal of Molecular Sciences 23, no. 12 (2022): 6780. http://dx.doi.org/10.3390/ijms23126780.

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Dendrobium sinense, an endemic medicinal herb in Hainan Island, is rich in bibenzyls. However, the key rate-limited enzyme involved in bibenzyl biosynthesis has yet to be identified in D. sinense. In this study, to explore whether there is a significant difference between the D. sinense tissues, the total contents of bibenzyls were determined in roots, pseudobulbs, and leaves. The results indicated that roots had higher bibenzyl content than pseudobulbs and leaves. Subsequently, transcriptomic sequencings were conducted to excavate the genes encoding type III polyketide synthase (PKS). A total

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4

Chiummiento, Lucia, Rosarita D’Orsi, Ilaria Caivano, Maria Funicello, and Paolo Lupattelli. "Structural Insights into the TES/TFA Reduction of Differently Substituted Benzofurans: Dihydrobenzofurans or Bibenzyls?" Synlett 32, no. 01 (2020): 63–68. http://dx.doi.org/10.1055/s-0040-1705949.

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AbstractVarious polysubstituted benzofurans were reduced by using triethylsilane in trifluoracetic acid. 2,3-Dihydrobenzofurans or bibenzyl compounds were obtained in high yields, depending on the nature of the substituents at C2 and on the benzene ring of the core structure. A p-anisole substituent at C2 of benzofurans always led to the corresponding bibenzyls.

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5

Imura, Yuka, Kenichi Harada, Miwa Kubo, and Yoshiyasu Fukuyama. "Three New Bibenzyls from the Twigs of Smilax longifolia." Natural Product Communications 12, no. 12 (2017): 1934578X1701201. http://dx.doi.org/10.1177/1934578x1701201216.

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Three new bibenzyl compounds, 1-3, were isolated along with the previously known bibenzyls 4-6, one diarylpropanoid 7, and three diarylheptanoids 8-10 from the twigs of Smilax longifolia. The structures of the new compounds were elucidated by analyzing their spectroscopic data and comparing them with those of known compounds. Diarylheptanoid 9 exhibited potent lethality in the brine shrimp lethality test (BST).

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6

Nam, Bomi, Ah-Reum Han, and Ik-Soo Lee. "Microbial Glycosylation of Phenanthrene and Bibenzyls by Mucor hiemalis." Natural Product Communications 15, no. 11 (2020): 1934578X2097450. http://dx.doi.org/10.1177/1934578x20974508.

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Microbial transformation of denthyrsinin (1), gigantol (2), and batatasin III (3), the major constituents of Dendrobium species (Orchidaceae), was performed using the filamentous fungus Mucor hiemalis KCTC 26779. Three glycosylated metabolites were obtained in the biotransformation of 1-3, and their structures were identified as denthyrsinin-6- O-β-d-glucoside (4), gigantol-5- O-β-d-glucoside (5), and batatasin III-3- O-β-d-glucoside (6) by analyzing 1-dimensional and 2-dimensional-nuclear magnetic resonance spectra, as well as high-resolution electrospray ionization mass spectral data. Among

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7

Zhang, Jiao-Zhen, Chan Wang, Ting-Ting Zhu, et al. "Spatial Distribution, Antioxidant Capacity, and Spore Germination-Promoting Effect of Bibenzyls from Marchantia polymorpha." Antioxidants 11, no. 11 (2022): 2157. http://dx.doi.org/10.3390/antiox11112157.

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Liverworts, considered to be the first plant type to successfully make the transition from water to land, can resist different oxidative stress. As characteristic constituents of liverworts, the bibenzyls are efficient antioxidants. In this study, spatial distributions of the bibenzyls within Marchantia polymorpha L., the model species of liverworts, were mapped using airflow-assisted desorption electrospray ionization imaging mass spectrometry. Bibenzyls were found to largely exist in the female receptacle of M. polymorpha, where lunularic acid was found to focus in the central region and bis

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8

Asakawa, Yoshinori, Fumihiro Nagashima, and Agnieszka Ludwiczuk. "Distribution of Bibenzyls, Prenyl Bibenzyls, Bis-bibenzyls, and Terpenoids in the Liverwort Genus Radula." Journal of Natural Products 83, no. 3 (2020): 756–69. http://dx.doi.org/10.1021/acs.jnatprod.9b01132.

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9

Chaofeng, Zhang, Wang Min, Lin Ping, Zhang Mian, Wang Zhengtao, and Xu Luoshan. "A new bibenzyl compound from Dendrobium gratiosissmum." Journal of Indian Chemical society Vol. 84, Jul 2007 (2007): 714–16. https://doi.org/10.5281/zenodo.5824487.

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Department of Pharmacognosy, China Pharmaceutical University, Nainjing, Jiangsn 210038, P. R. China <em>E-mail </em>: njchaofeng@126.cqm Fax : 86-25-85309639 <em>Manuscript received 9 November 2006, accepted 4 May 2007</em> A new bibenzyls compound, Isomoniliformine A, 1-{(7-hydroxy-5-methoxy-6-(18-(hydroxylmethyl)oxiranyl)- 16,18-dimethoxylphenoxy)-phenyl}-2-(11-methoxyphenyl)ethane, was isolated from stems of <em>Dendrobium gratiosissmum </em>Rchb. f. The structure of this unusual bibenzyl compound was determined by chemical and spectroscopic methods, particularly one- and two-dimension

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10

Takamiya, Tomoko, Manako Saito, Aoi Miyamoto, et al. "BBS Gene Expression and Its Diversity in the Genus Dendrobium." Diversity 16, no. 6 (2024): 337. http://dx.doi.org/10.3390/d16060337.

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Dendrobium officinale Kimura & Migo in the genus Dendrobium of Orchidaceae is an important medicinal plant that produces various bibenzyl and phenanthrene derivatives. In some orchids, these derivatives have been reported to increase with fungal infection. Bibenzyl biosynthesis is regulated by bibenzyl synthase (BBS). Although six genes of the BBS family have been registered from D. officinale, their gene regulation mechanisms are unclear. The infection of Dendrobium with mycorrhizal fungi also reportedly increases the expression of genes involved in biosynthesis; however, the effect of my

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11

Anchang, Kenneth Yongabi, Miroslav Novaković, Danka Bukvički, and Yoshinori Asakawa. "Bis-bibenzyls from the Cameroon Liverwort Marchantia debilis." Natural Product Communications 11, no. 9 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100934.

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Liverworts are rich sources of terpenoids and aromatic compounds among which bis-bibenzyls are well known for their wide spectrum of biological activities. This is the first report of chemical analysis of the African liverwort Marchantia debilis Goebel. From the methanol extract marchantinquinone-1′-methyl ether was newly isolated together with three known bis-bibenzyls, marchantin C, marchantinquinone and perrottetin E. The presence of bis-bibenzyls with a quinone moiety is noted for the first time in the Marchantia genus.

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12

Kongkatitham, Virunh, Adeline Dehlinger, Chatchai Chaotham, Kittisak Likhitwitayawuid, Chotima Böttcher, and Boonchoo Sritularak. "Diverse modulatory effects of bibenzyls from Dendrobium species on human immune cell responses under inflammatory conditions." PLOS ONE 19, no. 2 (2024): e0292366. http://dx.doi.org/10.1371/journal.pone.0292366.

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Dendrobium plants are widely used in traditional Chinese medicine. Their secondary metabolites such as bibenzyls and phenanthrenes show various pharmacological benefits such as immunomodulation and inhibitory effects on cancer cell growth. However, our previous study also showed that some of these promising compounds (i.e., gigantol and cypripedin) also induced the expression of inflammatory cytokines including TNF in human monocytes, and thus raising concerns about the use of these compounds in clinical application. Furthermore, the effects of these compounds on other immune cell populations,

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13

Ivkovic, Ivana, Danka Bukvicki, Miroslav Novakovic, et al. "Antibacterial properties of thalloid liverworts Marchantia polymorpha L., Conocephalum conicum (L.) Dum. and Pellia endiviifolia (Dicks.) Dumort." Journal of the Serbian Chemical Society 86, no. 12 (2021): 1249–58. http://dx.doi.org/10.2298/jsc210728084i.

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The antimicrobial activity of methanol extracts of three thalloid liverworts, Marchantia polymorpha, Conocephalum conicum and Pellia endiviifolia and bis-bibenzyl marchantin A, the most dominant compound in the methanol extract of M. polymorpha, have been investigated in this research. 1H-NMR spectroscopy revealed that the M. polymorpha and P. endiviifolia extracts of liverwort contain terpenes, oils, sugars and bis-bibenzyls, while these specific macrocyclic compounds were absent in the C. conicum extract. The antimicrobial potential was tested on eight bacterial strains. Antimicrobial effect

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14

Asakawa, Yoshinori. "The Isolation, Structure Elucidation, and Bio- and Total Synthesis of Bis-bibenzyls, from Liverworts and Their Biological Activity." Natural Product Communications 12, no. 8 (2017): 1934578X1701200. http://dx.doi.org/10.1177/1934578x1701200845.

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Little attention has been paid to the bryophytes for use in the human diet in spite of the presence of 23,000 species in the world. Some liverworts produce lipophilic terpenoids and phenolic bis-bibenzyls, possessing antimicrobial, antifungal, antiviral, cytotoxic, anti-oxidant, muscle relaxing, and antiobesity activities. In this review, the isolation, structures elucidation, bio- and total syntheses of bis-bibenzyls from several liverworts are discussed.

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15

Asakawa, Yoshinori. "Potential Source of Medicinal Compounds from Liverworts: Bibenzyls and Bis(bibenzyls)." Open Conference Proceedings Journal 4, no. 1 (2013): 8. http://dx.doi.org/10.2174/2210289201304010008.

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16

Arriaga-Giner, F. Javier, Eckhard Wollenweber, and Marion Dörr. "Bibenzyls from crowberry leaves." Phytochemistry 33, no. 3 (1993): 725–26. http://dx.doi.org/10.1016/0031-9422(93)85485-a.

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17

Zhao, Weimin, Guowei Qin, Yang Ye, Rensheng Xu, and Xiufang Le. "Bibenzyls from Stemona tuberosa." Phytochemistry 38, no. 3 (1995): 711–13. http://dx.doi.org/10.1016/0031-9422(94)00655-d.

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18

I., R. Siddiqui, Dwivedi Smriti, K. Shukla Pawan, and K. Singh Pravin. "Synthesis and fungicidal activity of 4,4' -bis[(2" -arylthiazolo[4,3-b]-1,3,4-oxadiazol-5" -yl)methoxy ]bibenzyls." Journal of Indian Chemical Society Vol. 83, Jan 2006 (2006): 89–93. https://doi.org/10.5281/zenodo.5816496.

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Laboratory of Green Technology. Department of Chemistry, University of Allahabad, Allahabad-211 002, Uttar Pradesh, India <em>E-mail</em> : smriti96@rediffmail.com <em>Manuscript received 14 July 2004, revised 18 July 2004, accepted 9 September 2005</em> Several 4,4' -bis(2" -aryl-4" -thiazolidinon-3' -yl-N-acetamidoxy)bibenzyls (4a-h) and 4,4' -bis[2" -arylthiazolo[4,3- b]-1,3,4-oxadiazol-5"-yl)methoxy]bibenzyls (5a-h) have been synthesized and tested for their antifungal activity.

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19

Novakovic, Miroslav, Agnieszka Ludwiczuk, Danka Bukvicki, and Yoshinori Asakawa. "Phytochemicals from bryophytes: Structures and biological activity." Journal of the Serbian Chemical Society 86, no. 12 (2021): 1139–75. http://dx.doi.org/10.2298/jsc211027100n.

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Little attention has been paid to the bryophytes as sources for human diet despite the presence of 23,000 species in the world. Some mosses contain Vitamin B1, tocopherols, prostaglandin-like highly unsaturated fatty acids and phenolic compounds. On the other hand, liverworts contain enantiomeric mono-, sesqui- and diterpenoids similar to those found in vascular plants. Additionally, they possess bibenzyls, bis-bibenzyls and polyketides, many of them showing various bioactivity, such as antimicrobial, antiviral, anti-inflammatory, cytotoxicity against cancer cell lines, muscle relaxing, antiox

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20

Hu, Jiang-Miao, Ji-Jun Chen, Hong Yu, You-Xing Zhao, and Jun Zhou. "Two novel bibenzyls fromDendrobium trigonopus." Journal of Asian Natural Products Research 10, no. 7 (2008): 647–51. http://dx.doi.org/10.1080/10286020802133605.

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21

Komala, Ismiarni, Takuya Ito, Fumihiro Nagashima, Yasuyuki Yagi, and Yoshinori Asakawa. "Cytotoxic Bibenzyls, and Germacrane- and Pinguisane-type Sesquiterpenoids from Indonesian, Tahitian and Japanese Liverworts." Natural Product Communications 6, no. 3 (2011): 1934578X1100600. http://dx.doi.org/10.1177/1934578x1100600301.

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Cytotoxic bibenzyls, and germacrane- and pinguisane-type sesquiterpenoids have been isolated from unidentified Indonesian and Tahitian Frullania sp. and Japanese Porella perrottetiana by using a combination of chromatographic methods. The structure activity relationship (SAR) study showed that the presence of a phthalide group in bibenzyls, an α-methylene-γ-lactone in germacrane-type sesquiterpenoids, and β-hydroxycarbonyl in pinguisane-type sesquiterpenoids play an important role in providing cytotoxic activity against both human promyelocytic leukemia (HL-60) and human pharyngeal squamous ca

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22

Ludwiczuk, Agnieszka, Fumihiro Nagashima, Rob S. Gradstein, and Yoshinori Asakawa. "Volatile Components from Selected Mexican, Ecuadorian, Greek, German and Japanese Liverworts." Natural Product Communications 3, no. 2 (2008): 1934578X0800300. http://dx.doi.org/10.1177/1934578x0800300205.

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Twenty-one liverworts from Mexico, Ecuador, Greece, Germany and Japan were extracted with diethyl ether and the crude extracts analyzed by TLC and GC/MS. Several volatile sesqui- and diterpenoids, and also bibenzyls were identified. Many of these compounds are important chemical markers of liverworts genus or family. Sacculatane-type diterpene dialdehydes occur in the Pelliaceae family, while bibenzyls, especially with a prenyl group are characteristic of the Japanese Radula perrottetii. Eudesman-type sesquiterpene lactones and pinguisane-type sesquiterpenoids are significant markers of Frulla

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23

Ivković, Ivana, Miroslav Novaković, Milan Veljić, et al. "Bis-Bibenzyls from the Liverwort Pellia endiviifolia and Their Biological Activity." Plants 10, no. 6 (2021): 1063. http://dx.doi.org/10.3390/plants10061063.

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Based on previous investigations where bis-bibenzyls isolated from liverworts showed various biological activities (cytotoxic, antimicrobial, and antiviral), we investigated their cytotoxic activity in several human cancer cell lines. From the methylene-chloride/methanol extract of the liverwort Pellia endiviifolia, three bis-bibenzyls of the perrottetin type were isolated, namely perrottetin E, 10′-hydroxyperrottetin E, and 10,10′-dihydroxyperrottetin E. The last two were found for the first time in this species. Their structures were resolved using 1D and 2D NMR, as well as by comparison wit

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24

Sen, Kakali, Mohammad Imtiyaj Khan, Raja Paul, Utsha Ghoshal, and Yoshinori Asakawa. "Recent Advances in the Phytochemistry of Bryophytes: Distribution, Structures and Biological Activity of Bibenzyl and Bisbibenzyl Compounds." Plants 12, no. 24 (2023): 4173. http://dx.doi.org/10.3390/plants12244173.

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Research on bryophyte phytochemistry has revealed the presence of different phytochemicals like fatty acids, terpenoids, small phenolic molecules, etc. Small phenolic molecules, i.e., bibenzyls (of two aromatic rings) and bisbibenzyls (four aromatic rings), are unique signature molecules of liverworts. The first bisbibenzyls marchantin A and riccardin A were discovered in two consecutive years, i.e., 1982 and 1983, respectively, by Asakawa and coworkers. Since then, about 70 bisbibenzyls have been reported. These molecules are characterized and identified using different spectroscopic techniqu

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25

Otoguro, Kazuhiko, Aki Ishiyama, Masato Iwatsuki, et al. "In vitro antitrypanosomal activity of bis(bibenzyls)s and bibenzyls from liverworts against Trypanosoma brucei." Journal of Natural Medicines 66, no. 2 (2011): 377–82. http://dx.doi.org/10.1007/s11418-011-0587-x.

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26

Nuamnaichati, Narawat, Utid Suriya, Hnin Ei Ei Khine, et al. "Arene Substitutions in Orchid Bibenzyls: Mechanistic Insights into Glucose Uptake and Lipid Metabolism for Targeting Metabolic Disorders." Nutrients 17, no. 7 (2025): 1104. https://doi.org/10.3390/nu17071104.

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Background: Phytochemicals possess diverse therapeutic potential; however, the impact of arene substitutions on the pharmacological properties of the bibenzyl compounds batatasin III and gigantol, derived from Dendrobium venustum, remains unexplored. Objectives: This study examines how structural differences between these compounds affect cellular glucose uptake and lipid metabolism during adipocyte differentiation. Methods: The effects of both bibenzyl compounds on cytotoxicity and glucose uptake were assessed in mouse and human pre-adipocytes and rat skeletal muscle myoblasts using colorimet

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27

L., R. Siddlqui, and Dwivedi Smriti. "Synthesis and fungicidal activity of 4,4' -bis[2"-(aryl/alkylimino )-4"-oxothiazolin-3"-yl-acetamidoxy)bibenzyls and 4,4' -bis(oxadiazolylmethoxy)bibenzyls." Journal of Indian Chemical Society Vol. 86, Feb 2009 (2009): 149–52. https://doi.org/10.5281/zenodo.5807433.

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Laboratory of Green Technology, Department of Chemistry, Allahabad University, Allahabad-211 002, Uttar Pradesh, India Galgotia College of Engineering & Technology, Knowledge Park, Geater Noida, Uttar Pradesh, India <em>E-mail</em>: smriti96@rediffmail.com <em>Manuscript received 2 February 2007, revised 11 July 2008, acepted 24 September 2008</em> Chemoselective facile synthesis of novel 4,4''-bis[2<em>"-</em>(aryl/alkylimino)-4<em>"</em> -oxothlazolln-3<em>"</em> -ylacetamldoxy]- bibenzyls (5a-e) and 4,4''-bis(oxadiazolylmethoxy)bibenzyls (6a-e) are reporte

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28

Xiao, Shiji, Yike Fang, Lei Cheng, et al. "Two New Bibenzyls from Dendrobium hercoglossum." Records of Natural Products, no. 2 (November 2, 2021): 1–5. http://dx.doi.org/10.25135/rnp.291.2109.2198.

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29

Keserű, G. M., and M. Nógrádi. "The chemistry of macrocyclic bis(bibenzyls)." Nat. Prod. Rep. 12, no. 1 (1995): 69–75. http://dx.doi.org/10.1039/np9951200069.

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30

Baek, Seung-Hwa, Richard K. Phipps, and Nigel B. Perry. "Antimicrobial Chlorinated Bibenzyls from the LiverwortRiccardiamarginata." Journal of Natural Products 67, no. 4 (2004): 718–20. http://dx.doi.org/10.1021/np030455c.

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31

Asakawa, Yoshinori, Agnieszka Ludwiczuk, Miroslav Novakovic, Danka Bukvicki, and Kenneth Yongabi Anchang. "Bis-bibenzyls, Bibenzyls, and Terpenoids in 33 Genera of the Marchantiophyta (Liverworts): Structures, Synthesis, and Bioactivity." Journal of Natural Products 85, no. 3 (2021): 729–62. http://dx.doi.org/10.1021/acs.jnatprod.1c00302.

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32

Asakawa, Yoshinori, Masao Toyota, Motoo Tori, and Toshihiro Hashimoto. "Chemical structures of macrocyclic bis(bibenzyls) isolated from liverworts (Hepaticae)." Spectroscopy 14, no. 4 (2000): 149–75. http://dx.doi.org/10.1155/2000/570265.

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Liverworts (Hepaticae) produce a number of macrocyclic bis(bibenzyls) which show interesting biological activity and are of very valuable for the chemosystematic study of liverworts. The structural elucidation of these characteristic natural products are reviewed.

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33

Nagashima, Fumihiro, and Yoshinori Asakawa. "Terpenoids and Bibenzyls from Three Argentine Liverworts." Molecules 16, no. 12 (2011): 10471–78. http://dx.doi.org/10.3390/molecules161210471.

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34

Labbé, Cecilia, Francesca Faini, Carolina Villagrán, Josep Coll, and David S. Rycroft. "Bioactive Polychlorinated Bibenzyls from the LiverwortRiccardia polyclada." Journal of Natural Products 70, no. 12 (2007): 2019–21. http://dx.doi.org/10.1021/np070192c.

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35

Chia-Li Wu and Hsiang-Ru Lin. "Labdanoids and bis(bibenzyls) from Jungermannia species." Phytochemistry 44, no. 1 (1997): 101–5. http://dx.doi.org/10.1016/s0031-9422(96)00519-5.

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36

Anton, Hermann, Ludwig Kraut, Rüdiger Mues, and I. Z. Morales Maria. "Phenanthrenes and bibenzyls from a Plagiochila species." Phytochemistry 46, no. 6 (1997): 1069–75. http://dx.doi.org/10.1016/s0031-9422(97)00344-0.

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37

Cullmann, Frank, and Hans Becker. "Prenylated Bibenzyls from the Liverwort Radula laxiramea." Zeitschrift für Naturforschung C 54, no. 3-4 (1999): 147–50. http://dx.doi.org/10.1515/znc-1999-3-401.

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From Radula laxiramea, 12 bibenzyl derivatives and the common bisbibenzyl perrottetin E were isolated. Two compounds are described for the first time as natural products, and one, previously only known after derivatisation, was found in genuine form . Perrottetinene, a cannabinoid from a liverwort is worth mentioning.

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38

Asakawa, Yoshinori, Keiko Kondo, Née K. Takikawa, Motoo Tori, Toshihiro Hashimoto, and Shunichi Ogawa. "Prenyl bibenzyls from the liverwort Radula kojana." Phytochemistry 30, no. 1 (1991): 219–34. http://dx.doi.org/10.1016/0031-9422(91)84129-g.

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39

Apisantiyakom, Samneang, Prasat Kittakoop, Thanaporn Manyum, Kanyawim Kirtikara, John?B Bremner, and Yodhathai Thebtaranonth. "Novel Biologically Active Bibenzyls fromBauhinia saccocalyx Pierre." Chemistry & Biodiversity 1, no. 11 (2004): 1694–701. http://dx.doi.org/10.1002/cbdv.200490127.

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40

Krauss, Jürgen, Ursula Kopp, and Franz Bracher. "Short microwave-assisted modular synthesis of naturally occurring oxygenated bibenzyls." Zeitschrift für Naturforschung B 70, no. 9 (2015): 637–41. http://dx.doi.org/10.1515/znb-2015-0047.

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AbstractThe naturally occurring oxygenated bibenzyls lunularin and m-O-methyllunularin were prepared in a modular synthesis in four steps from two appropriate iodophenols and trimethylsilylacetylene utilizing microwave-assisted Sonogashira couplings as the crucial steps. The antimicrobial activity of the resulting natural products was evaluated in an agar diffusion assay.

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41

Asakawa, Yoshinori, Masao Toyota, Toshihiro Hashimoto, Motoo Tori, Fumihiro Nagashima, and Liva Harinantenaina. "Marchantiophyta (Liverworts): Rich Sources of Macrocyclic Bis(bibenzyls)." HETEROCYCLES 76, no. 1 (2008): 99. http://dx.doi.org/10.3987/rev-08-sr(n)3.

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42

S. Vairappan, Charles, Shean-Yeaw Ng, Takashi Kamada, Chin-Soon Phan, and Monica Suleiman. "New Prenylated Bibenzyls from Bornean Liverwort Acrobolbus saccatus." HETEROCYCLES 96, no. 11 (2018): 1958. http://dx.doi.org/10.3987/com-18-13981.

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43

Chanvorachote, Pithi, Akkarawut Kowitdamrong, Thidarat Ruanghirun, Boonchoo Sritularak, Chutichot Mungmee, and Kittisak Likhitwitayawuid. "Anti-metastatic Activities of Bibenzyls from Dendrobium pulchellum." Natural Product Communications 8, no. 1 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800127.

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Abstract:

Our investigation of the stem of Dendrobium pulchellum resulted in the isolation of four known bibenzyls, chrysotobibenzyl (1), chrysotoxine (2), crepidatin (3) and moscatilin (4). The present study reveals for the first time the ability of these four compounds to facilitate anoikis and inhibit the growth of lung cancer cells in anchorage-independent condition. The preliminary data obtained disclose the inhibitory effect on cancer cell metastasis of the isolated compounds, and provide an important new approach for cancer drug development.

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Bai, Li, Noriko Masukawa, Masae Yamaki, and Shuzo Takagi. "A polyphenol and two bibenzyls from Pleione bulbocodioides." Phytochemistry 47, no. 8 (1998): 1637–40. http://dx.doi.org/10.1016/s0031-9422(97)00785-1.

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Friederich, Susanne, Ulrich H. Maier, Brigitte Deus-Neumann, Yoshinori Asakawa, and Meinhart H. Zenk. "Biosynthesis of cyclic bis(bibenzyls) in Marchantia polymorpha." Phytochemistry 50, no. 4 (1999): 589–98. http://dx.doi.org/10.1016/s0031-9422(98)00557-3.

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Anton, Hermann, Ralph Schoeneborn, and Ruediger Mues. "Bibenzyls and bisbibenzyls from a neotropical Plagiochila species." Phytochemistry 52, no. 8 (1999): 1639–45. http://dx.doi.org/10.1016/s0031-9422(99)00394-5.

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Morita, Hiroshi, Kazumasa Zaima, Ikumi Koga, et al. "Vasorelaxant effects of macrocyclic bis(bibenzyls) from liverworts." Bioorganic & Medicinal Chemistry 19, no. 13 (2011): 4051–56. http://dx.doi.org/10.1016/j.bmc.2011.05.019.

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Chen, Ye-Gao, Jiang-Tao Li, Ben-Lin Yin, and Ying Liu. "Bibenzyls, 9,10-dihydrophenanthrenes, and phenanthraquinone from Dendrobium longicornu." Chemistry of Natural Compounds 46, no. 5 (2010): 790–91. http://dx.doi.org/10.1007/s10600-010-9743-x.

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Li, Yu-Peng, Ya-Juan Wang, and Li-Ling Chen. "Antioxidant Bibenzyls, Phenanthrenes, and Fluorenones from Dendrobium chrysanthum." Chemistry of Natural Compounds 52, no. 1 (2016): 90–92. http://dx.doi.org/10.1007/s10600-016-1554-2.

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Veerraju, P., N. S. Prakasa Rao, L. Jaganmohan Rao, K. V. Jagannadha Rao, and R. Mohana Rao. "Bibenzyls and phenanthrenoids of some species of orchidaceae." Phytochemistry 28, no. 11 (1989): 3031–34. http://dx.doi.org/10.1016/0031-9422(89)80273-0.

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