Relevant bibliographies by topics / Biochemical markers of transformation

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  2. Dissertations / Theses
  3. Books
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Academic literature on the topic 'Biochemical markers of transformation'

Author: Grafiati
Published: 9 March 2023
Last updated: 19 July 2025

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Journal articles on the topic "Biochemical markers of transformation"

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Lindström-Seppä, Pirjo, Katalin Urban, Ulla Honkalampi-Hämäläinen, and Sashwati Roy. "Biochemical Responses in Aquatic Plants as Markers of Environmental Contamination." Alternatives to Laboratory Animals 29, no. 3 (2001): 277–82. http://dx.doi.org/10.1177/026119290102900312.

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This short review gives several examples of the current status of xenobiotic bio-transformation reactions and oxidative stress responses in plants as biomarkers of organic pollution in aquatic environments. Based on previous basic knowledge, several biomonitoring programmes have been successfully applied during the last decade.
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Havelková, Marcela, Tomáš Randák, Jana Blahová, Iveta Slatinská, and Zdeňka Svobodová. "Biochemical markers for the assessment of aquatic environment contamination." Interdisciplinary Toxicology 1, no. 2 (2008): 169–81. http://dx.doi.org/10.2478/v10102-010-0034-y.

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Biochemical markers for the assessment of aquatic environment contaminationThe need for assessment of aquatic ecosystem contamination and of its impact on water dwelling organisms was developed in response to rising aquatic environmental pollution. In this field study, liver enzymes of phase I and phase II of xenobiotic transformation, namely cytochrome P450, ethoxyresorufin-O-deethylase, glutathione-S-transferase and tripeptide glutathione were used to assess the contamination of the aquatic environment at different rivers in the Czech Republic. The indicator species selected was the male chub (Leuciscus cephalusL.) and male brown trout (Salmo trutta fario). Chemical analyses included also the assessment of the most important inductors of previously mentioned biochemical markers. The major inductors of monitored biomarkers are industrial contaminants which belong to a large group of organic pollutants (PCB, PAH, PCDD/F, DDT, HCH, HCB and OCS), persistent in the environment. Four different groups of river basins were assessed: the River Tichá Orlice and its tributary the Kralický brook; important tributaries of the River Elbe (the rivers Orlice, Chrudimka, Cidlina, Jizera, Vltava, Ohře and Bílina); major rivers in the Czech Republic (the rivers Lužnice, Otava, Sázava, Berounka, Vltava, Labe, Ohře, Svratka, Dyje, Morava and Odra) and the River Vltava. The use of the biochemical markers together with chemical analyses seems to be an effective way to monitor the quality of aquatic environment.
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Bates, P. A. "Complete developmental cycle ofLeishmania mexicanain axenic culture." Parasitology 108, no. 1 (1994): 1–9. http://dx.doi.org/10.1017/s0031182000078458.

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SUMMARYA complete developmental sequence ofLeishmania mexicanahas been produced in axenic culture for the first time. This was achieved by manipulation of media, pH and temperature conditions over a period of 16 days. All experiments were initiated with lesion amastigotes that were transformed to multiplicative promastigotes by culture in HOMEM, 10% foetal calf serum, pH 7·5, at 25 °C. Metacyclogenesis was induced by subpassage in Schneider'sDrosophila medium, 20% foetal calf serum, pH 5·5, and the resulting forms transformed to axenically growing amastigotes by subpassage in the same medium and raising the temperature to 32 °C. Parasites from each day were characterized with respect to their general morphology using light microscopy of Giemsa-stained smears, and biochemically by analysis of total protein content, proteinases, nucleases and secretory acid phosphatase. The results demonstrated that the three main stages identified - amastigotes, multiplicative promastigotes and metacyclic promastigotes - each exhibited the expected suite of biochemical properties. Further, the changes in morphology observed as the developmental sequence proceeded from stage to stage were accompanied by appropriate changes in biochemical properties. These results provide both useful biochemical markers and a culture system in which to examine the regulation of differentiation and transformation during theLeishmanialife-cycle.
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Coradduzza, Donatella, Leonardo Sibono, Alessandro Tedde, et al. "Diagnostic Stratification of Prostate Cancer Through Blood-Based Biochemical and Inflammatory Markers." Diagnostics 15, no. 11 (2025): 1385. https://doi.org/10.3390/diagnostics15111385.

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Background: Prostate cancer (PCa) remains one of the most prevalent malignancies in men, with diagnostic challenges arising from the limited specificity of current biomarkers, like PSA. Improved stratification tools are essential to reduce overdiagnosis and guide personalized patient management. Objective: This study aimed to identify and validate clinical and hematological biomarkers capable of differentiating PCa from benign prostatic hyperplasia (BPH) and precancerous lesions (PL) using univariate and multivariate statistical methods. Methods: In a cohort of 514 patients with suspected PCa, we performed a univariate analysis (Kruskal–Wallis and ANOVA) with preprocessing via adaptive Box–Cox transformation and missing value imputation through probabilistic principal component analysis (PPCA). LASSO regression was used for variable selection and classification. An ROC curve analysis assessed diagnostic performance. Results: Five variables—age, PSA, Index %, hemoglobin (HGB), and the International Index of Erectile Function (IIEF)—were consistently significant across univariate and multivariate analyses. The LASSO regression achieved a classification accuracy of 70% and an AUC of 0.74. Biplot and post-hoc analyses confirmed partial separation between PCa and benign conditions. Conclusions: The integration of multivariate modeling with reconstructed clinical data enabled the identification of blood-based biomarkers with strong diagnostic potential. These routinely available, cost-effective indicators may support early PCa diagnosis and patient stratification, reducing unnecessary invasive procedures.
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Desjardins, M., LA Huber, RG Parton, and G. Griffiths. "Biogenesis of phagolysosomes proceeds through a sequential series of interactions with the endocytic apparatus." Journal of Cell Biology 124, no. 5 (1994): 677–88. http://dx.doi.org/10.1083/jcb.124.5.677.

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We have examined the modifications occurring during the transformation of phagosomes into phagolysosomes in J-774 macrophages. The use of low density latex beads as markers of phagosomes (latex bead compartments, LBC) allowed the isolation of these organelles by flotation on a simple sucrose gradient. Two-dimensional gel electrophoresis, immunocytochemistry, and biochemical assays have been used to characterize the composition of LBC at different time points after their formation, as well as their interactions with the organelles of the endocytic pathway. Our results show that LBC acquire and lose various markers during their transformation into phagolysosomes. Among these are members of the rab family of small GTPases as well as proteins of the lamp family. The transfer of the LBC of lamp 2, a membrane protein associated with late endocytic structures, was shown to be microtubule dependent. Video-microscopy showed that newly formed phagosomes were involved in rapid multiple contacts with late components of the endocytic pathway. Collectively, these observations suggest that phagolysosome formation is a highly dynamic process that involves the gradual and regulated acquisition of markers from endocytic organelles.
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Kolgi, Rajeev Ramachandra, Bhargavi G, Nataraju Angaswamy, M. V. Srinivasulu, and S. Shankara Somashetty. "A Short Review - Biochemical Aspects and Advancements in Gastric Cancer." Biosciences Biotechnology Research Asia 21, no. 1 (2024): 69–79. http://dx.doi.org/10.13005/bbra/3203.

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ABSTRACT: Malignancy in the stomach is one of the silent causes of mortality due to a bad prognosis regardless of gender. It is the world's Fourth leading cause of death It is a disorder in which cancerous cells form in the stomach lining. The primary relationships begin between its carcinogenic route and Helicobacter pylori infection, following inflammation, and tissue regeneration. The review aims to evaluate biochemistry related to gastric cancer which focuses on cancer research including etiology, molecular basis, malignant transformation, tumor markers, prognosis, advancements in gastric (stomach) cancer and its therapeutics. The study of prognosis and advancements in gastric cancer helps a researcher, medical practitioner, or surgeon to develop safe, minimally invasive, and effective methods to prevent, screen, diagnose, and treat gastric cancer.
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Alves, Adriana Cristina, Vera Maria Quecini, and Maria Lucia Carneiro Vieira. "PLANT TRANSFORMATION: ADVANCES AND PERSPECTIVES." Scientia Agricola 56, no. 1 (1999): 1–8. http://dx.doi.org/10.1590/s0103-90161999000100001.

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Genetic transformation is a powerful tool for plant breeding and genetical, physiological or biochemical research, consequently it is an extremely dynamic field. Transgenic plants are commonly used to complete or substitute mutants in basic research, helping the studies of complex biological situations such as pathogenesis process, genome organization, light reception and signal transduction. In this review, recent approaches for foreign gene introduction (e.g. Agrobiolistics, whole tissue electroporation, in planta Agrobacterium transformation), screening (reporter gene possibilities and performance) and transformant selection (ipt selective marker) are discussed. Transgene expression and mechanisms underlying (trans)gene inactivation are presented. Practical applications of genetically modified plants, field tests and commercial transgenic crops worldwide and in Brazil are listed, as well as the main traits and species modified. Potential uses of transgenic plants for animal compound production, biological remediation and synthetic polymer assembly are also shown.
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Maitra, Ishaan, Camilo L. M. Morais, Kássio M. G. Lima, et al. "Attenuated Total Reflection Fourier-Transform Infrared Spectral Discrimination in Human Tissue of Oesophageal Transformation to Adenocarcinoma." Journal of Personalized Medicine 13, no. 8 (2023): 1277. http://dx.doi.org/10.3390/jpm13081277.

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This study presents ATR-FTIR (attenuated total reflectance Fourier-transform infrared) spectral analysis of ex vivo oesophageal tissue including all classifications to oesophageal adenocarcinoma (OAC). The article adds further validation to previous human tissue studies identifying the potential for ATR-FTIR spectroscopy in differentiating among all classes of oesophageal transformation to OAC. Tissue spectral analysis used principal component analysis quadratic discriminant analysis (PCA-QDA), successive projection algorithm quadratic discriminant analysis (SPA-QDA), and genetic algorithm quadratic discriminant analysis (GA-QDA) algorithms for variable selection and classification. The variables selected by SPA-QDA and GA-QDA discriminated tissue samples from Barrett’s oesophagus (BO) to OAC with 100% accuracy on the basis of unique spectral “fingerprints” of their biochemical composition. Accuracy test results including sensitivity and specificity were determined. The best results were obtained with PCA-QDA, where tissues ranging from normal to OAC were correctly classified with 90.9% overall accuracy (71.4–100% sensitivity and 89.5–100% specificity), including the discrimination between normal and inflammatory tissue, which failed in SPA-QDA and GA-QDA. All the models revealed excellent results for distinguishing among BO, low-grade dysplasia (LGD), high-grade dysplasia (HGD), and OAC tissues (100% sensitivities and specificities). This study highlights the need for further work identifying potential biochemical markers using ATR-FTIR in tissue that could be utilised as an adjunct to histopathological diagnosis for early detection of neoplastic changes in susceptible epithelium.
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Jia, Dan, Siqi Jin, Jin Zhang, et al. "Dynamic Changes in Metabolites and Transformation Pathways in Diqing Tibetan Pig Hams During Fermentation Determined by Widely Targeted Metabolomic Analysis." Foods 14, no. 14 (2025): 2468. https://doi.org/10.3390/foods14142468.

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This study investigated the metabolite dynamic changes and transformation pathways in Diqing Tibetan pig (DTP) hams during fermentation (0, 30, 90, 180, 360, 540 d) by widely targeted metabolomics. A total of 873 metabolites in 17 subclasses were detected, with significant changes in 448 metabolites. Additionally, 65 key metabolites were found to be involved in the top 10 pathways, with the top pathways for metabolite markers in mature hams including protein metabolism (2-oxocarboxylic acid metabolism, tryptophan metabolism and amino acid biosynthesis) and lipid metabolism (unsaturated fatty acid biosynthesis and linoleic acid metabolism). Overall, the unique DTP ham taste, flavor, and nutritional value may be contributed to by the significant accumulation of essential amino acids, MSG-like amino acids, free fatty acids (arachidonic acid, docosahexaenoic acid, and eicosapentaenoic acid), citric acid, oxaloacetic acid, succinic acid, and vitamin B. This study facilitates a comprehensive understanding of metabolic profiling and the transformation pathways of DTP hams during fermentation, providing novel insights into the biochemical mechanisms underlying traditional Tibetan pig hams, bridging traditional knowledge with modern omics technologies.
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Djukic, Vojko, Ljiljana Janosevic, Milovan Dimitrijevic, Svetozar Damjanovic, Predrag Pesko, and Jelena Dotlic. "Genetic markers for head and neck cancers: Current state of art and perspectives." Jugoslovenska medicinska biohemija 22, no. 4 (2003): 273–82. http://dx.doi.org/10.2298/jmh0304273d.

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This article analyzes the genetic markers of planocellular head and neck cancers from the aspect of theoretical basis for their identification and application, actual state of research in this field and benefit that could be expected from their introduction into clinical practice. In spite of unquestionable progress of diagnostics and treatment of planocellular cancer of the head and neck, there has been no evident improvement of five-year survival during the last two decades, due to which the attempts have been made for global diagnostics and therapeutic orientation to be directed towards the detection of changes at molecular level. Tumor markers are defined as biochemical indicators of the existing tumors. They include the structural changes of nucleic acids (DNA and RNA), when genetic markers are in question, the development of new or modified antigens at the cell surface, the synthesis of specific plasma proteins and eutopic/ectopic hormone production. The changes of gene structure, in tumor tissue or somatic cells that are easily accessible are verified by molecular-biological techniques, and the initial step is the amplification of the genome part which is considered significant (polymerase chain reaction technique). The presence or absence of specific tumor marker, as well as its phenotypic characteristics may be verified in tumor tissue or body fluids by immunochemical methods including the immunohistochemistry before all, owing to availability of a large number of mono- and polyclonal antibodies. While some fields of oncology have been using the benefits of specific tumor markers for years, no adequate solution for the treatment of planocellular head and neck cancers can be seen yet. Currently, it is clear that there is not a single specific marker for head and neck cancer or for the group of planocellular cancers as a whole, while the literature is plentiful of different and very often contradictory findings. The greatest attention has been paid to the study of P53 gene, either isolated or in the group of other potential markers such as cycline D1, growth transformation factor, vascular endothelium growth factor, E-katherin and collagen VII. The insights obtained by these studies have encouraged the attempts to use the genetic markers for managing several crucial clinical issues, such as early detection of premalignant and malignant lesions, early detection of local recurrence and distant metastasis, early prevention of secondary tumors, and especially, the selection of patients for specific therapy.
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Dissertations / Theses on the topic "Biochemical markers of transformation"

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PROCACCIANTI, CLAUDIO. "Quantitative evaluation of in vitro transformation by analysis of morphological and biochemical markers and statistical descriptors." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2012. http://hdl.handle.net/10281/28450.

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The EC directive REACH (EC1907/2006) sets, amongst others, the need for all the chemicals to be tested for their carcinogenic potential. In vitro assays can provide a fast and reliable tool for screening purposes. The Cell Transformation Assay (CTA) is one of the in vitro assays in the most advanced phase of the validation process and the only one able to evaluate both the genotoxic and the non-genotoxic potentials. The evaluation of results of the CTA is based on the scoring of transformed colonies (foci) by a trained expert on the basis of their morphological features. Levels of cell packing and multilayered growth, as well as fibroblastic shape of cells, criss-crossing and invasion of the surrounding monolayer features are evaluated for classification. While the decision making process is based on standard criteria, their interpretation is potentially biased, especially in borderline cases, due to a certain degree of subjectivism inherent in the evaluation of qualitative features. This aspect is critical towards the international validation of the CTA assay: subjectivity driven error might in fact result in under or over estimation of the carcinogenic potential of tested compounds. In this work, different approaches were used to develop an objective method to give decisional support to the operator in the classification procedure. Biological markers related to the transformation process (p53, cx43), and to a general cell stress (Hsp70) were analyzed. A novel technique for the in focus localization of biological markers of transformation was developed. RNA whole genome screening was used to set the conditions for future molecular characterization of foci-derived cell lines. A novel, Quantitative Index of Dissimilarity has been obtained by statistical descriptors capturing morphological features and employing an unsupervised image analysis approach, in order to help the operator in the decisional process of scoring the borderline cases.
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Wavrek, David A. "Role of sulphur in altering maturity-dependent biomarker transformations - a quantitative approach /." Access abstract and link to full text, 1992. http://0-wwwlib.umi.com.library.utulsa.edu/dissertations/fullcit/9222155.

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Allen, Marcus Christopher. "Biochemical markers of pulmonary oxygen toxicity." Thesis, University of Aberdeen, 1989. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.277226.

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This study has investigated potential biochemical markers of pulmonary oxygen toxicity (POT). Toxicity was investigated in male Sprague Dawley rats exposed to oxygen partial pressures ranging from 0.21-2.5 bars. It is known that prolonged exposure to 1 bar of oxygen damages pulmonary endothelial cells and so the biochemical functions of these cells have been studied. Control isolated perfused rat lungs were able to clear and/or metabolise a wide range of substances including 5-HT, PGE2, bradykinin, and angiotensin 1, all endothelial cell functions. As expected 5-HT clearance was compromised in isolated perfused rat lung obtained from rats exposed to 1 bar of oxygen, confirming endothelial cell damage. However the clearance of 5-HT by lungs obtained from rats exposed to 2.5 bars was normal, implying that the site of toxicity is different at these partial pressures. In addition enhancement of toxicity by vitamin E deficiency was not associated with endothelial cell damage at 2.5 bar. At the molecular level oxygen free radicals are thought to be the causative agents of POT. The radicals are reputed to damage lipids, but a process of peroxidation. One of the lipid fragment products of ω6 polyunsaturated fatty acids is n-pentane, a compound which is excreted on the breath. Monitoring of this compound during exposure to 0.21, 1.0, 2.5 bars of oxygen even in vitamin E deficient rats did not show a rise in pentane expiration in response to oxygen exposure. This implies that peroxidation of ω6 polyunsaturated fatty acids did not take place, although other lipids may have been peroxidised. In conclusion the site of POT may depend on the partial pressure of oxygen. Endothelial cell damage is probably absent during exposure to 2.5 bars of oxygen. In addition n-pentane monitoring, a reputed marker of POT, failed to reveal lipid perodixation during exposure to hyperoxia.
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Israngkun, na Ayudthaya Porn Paul. "Potential biochemical markers for infantile autism /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487322984315317.

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Maissa, Cecile A. "Biochemical markers and contact lens wear." Thesis, Aston University, 1999. http://publications.aston.ac.uk/9627/.

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The project objective was to develop a reliable selection procedure to match contact lens materials with individual wearers by the identification of a biochemical marker for assessment of in-eye performance of contact lenses. There is a need for such a procedure as one of the main reasons for contact lens wearers ceasing wearing contact lenses is poor end of day comfort i.e. the lenses become intolerable to the wearer as the day progresses. The selection of an optimal material for individual wearers has the potential benefit to reduce drop Qut, hence increasing the overall contact lens population, and to improve contact lens comfort for established wearers. Using novel analytical methods and statistical techniques, we were able to investigate the interactions between the composition of the tear film and of the biofilm deposited on the contact lenses and contact lens performance. The investigations were limited to studying the lipid components of the tear film; the lipid layer, which plays a key role in preventing evaporation and stabilising the tear film, has been reported to be significantly thinner and of different mixing characteristics during contact lens wear. Different lipid families were found to influence symptomatology, in vivo tear film structure and stability as well as ocular integrity. Whereas the symptomatology was affected by both the tear film lipid composition and the nature of the lipid deposition, the structure of the tear film and its stability were mainly influenced by the tear film lipid composition. The ocular integrity also appeared to be influenced by the nature of the lipid deposition. Potential markers within the lipid species have been identified and could be applied as follows: When required in order to identify a problematic wearer or to match the contact lens material to the contact lens wearer, tear samples collected by the clinician could be dispatched to an analytical laboratory where lipid analysis could be carried out by HPLC. A colorimetric kit based on the lipid markers could also be developed and used by clinician directly in the practice; such a kit would involve tear sampling and classification according to the colour into "Problem", "Border line" and "Good" contact lens wearers groups. A test kit would also have wider scope for marketing in other areas such as general dry-eye pathology.
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Branca, Francesco. "Biochemical markers of skeletal growth in children." Thesis, University of Aberdeen, 1995. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.282683.

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This work focused on the application to growth studies of the assay for pyridinium crosslinks in urine. The study showed the existence of a nyctohermeral rhythm of crosslink excretion in children, with a peak during the night or early in the morning, and pointed out between-day fluctuations of excretion (17% for Pyd and 19% for Dpd). The study also showed that urinary crosslinks were significantly related to anthropometric estimates of skeletal mass and that such estimates should be used to account for size differences between individuals. Cross-sectional observations on 272 children (3-18 years) showed a parallelism between the height velocity curve and the age profile of crosslink excretion. In 3-5 year old children, the study pointed out a positive relationship with monthly height velocity (R = 0.20); 5-month integrated values of excretion were also correlated to 5-month height velocity (R = 0.78 for Pyd; R = 0.73 for Dpd). Urinary crosslinks were normal in 53 children (124±34 months) affected by miscellaneous conditions leading to growth defects, in 14 children (117±47 months) affected by coeliac disease, nor in 20 children affected by GH deficiency or short stature (aged 117±20 months); they were in the high range in 7 girls with Turner's syndrome, in 58 malnourished boys (14±14 months), urinary crosslinks were proportional to the degree of wasting and were positively correlated to the rate of height gain during hospitalisation. In children treated with Growth Hormone, except those affected by Turner's syndrome, crosslinks could predict 6-month growth after the first month of therapy.
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Åkesson, Kristina. "Fracture and biochemical markers of bone metabolism." Lund : University of Lund, Dept. of Orthopaedics, Malmö General Hospital, Sweden, 1995. http://books.google.com/books?id=Ib9qAAAAMAAJ.

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McCoy, Paula K. "Psychological Hardiness and Biochemical Markers of Acute Stress." Thesis, University of North Texas, 2001. https://digital.library.unt.edu/ark:/67531/metadc2884/.

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The establishment of physiological norms for psychologically hardy vs. non-hardy individuals was attempted by examination of levels of salivary cortisol and urinary norepinephrine before and after a mid-term examination stressor. Normative data was collected on the reported frequency of stressors and their severity one week prior to the examination, and self-reported ratings of stress immediately prior to the examination. Performance on the examination as a function of hardiness was explored. Associations between demographic variables and psychological hardiness were also studied. Results from this study were inconclusive in establishing physiological norms for psychologically hardy individuals. Associations were found between: 1) hardiness and frequency of stressors; 2) hardiness and age; and 3) self-reported ratings of stress and anxiety as measured by the State-Trait Anxiety Inventory (STAI).
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Morgan, Tanya G. "Biochemical and mobility markers in osteoarthritis of the knee." Thesis, University of Sunderland, 2003. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.269194.

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Glassbrook, Norman J. "Biochemical markers for the detection and classification of Aspergillus." Thesis, Cardiff University, 2008. http://orca.cf.ac.uk/54802/.

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The genus Aspergillus includes a diverse group of filamentous fungi that are widely distributed in nature, commonly found in soil. The Aspergilli include species that can be beneficial or detrimental to humans, so detection and accurate identification of these organisms can be very important. Morphology and genetic sequence analysis are well established methods for classifying and identifying fungi, but morphology remains a widely used technique that generally works well for Aspergilli. However, some organisms may be misidentified due to atypical morphology and some hidden (cryptic) species may not be recognized as different from named species based on readily observable traits. In this study, reference strains of different Aspergillus species, <italic>Penicillium chrysogenum, Candida albicans,</italic> and <italic>Cryptococcus neoformans </italic> were characterized using LC/MS and GC/MS biochemical profiling techniques in order to find specific small molecules, peptides or biochemical profiles that can be used in addition to established methods to detect and classify Aspergilli to the species level. Subsequently, analytical methods developed for characterizing the reference strains were applied, along with morphology and PCR, to characterize and identify several laboratory and field isolates. Some unique compounds and biochemical patterns did emerge from small molecule profiling that could be used for classifying Aspergilli, but protein profiling by LC/MS/MS was a much more effective approach. Tandem mass spectra from LC/MS/MS of tryptic peptides from fungal proteins were searched against protein databases and matched to theoretical spectra derived from those databases. Many of the amino acid sequences detected were taxonomically diagnostic for classifying Aspergillus species. Protein profiling also provided a great deal of additional biochemical information on the test organisms by identifying the predominant enzymes and structural proteins present under different experimental conditions and may find broader application for identifying and studying other organisms.
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Books on the topic "Biochemical markers of transformation"

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Koopmans, Martin P. Diagenetic and catagenetic transformations of sequestered biomarkers. Faculteit Aardwetenschappen, Universiteit Utrecht, 1997.

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R, Eastell, and Bone Markers: Biochemical and Clinical Perspectives Workshop (2000 : Geneva, Switzerland), eds. Bone markers: Biochemical and clinical perspectives. Martin Dunitz, 2001.

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Kagaku Gijutsu Shinkō Kikō. Kenkyū Kaihatsu Senryaku Sentā. Sentā Rinshō Igaku Yunitto. Chōkōrei shakai ni okeru sensei iryō no suishin =: Promoting preemptive medicine in a hyper-aged society. Kagaku Gijutsu Shinkō Kikō Kenkyū Kaihatsu Senryaku Sentā Rinshō Igaku Yunitto, 2011.

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Kim, Sang-gyŏm. Saenghwahakchŏk pʻyojija mit taeri kyŏlgwa pyŏnsu ŭi PK/PD modelling chŏgyong e kwanhan yŏnʼgu =: The study for evaluation of PK/PD modeling using biomarker and surrogate endpoint. Sikpʻum Ŭiyakpʻum Anjŏnchʻŏng, 2007.

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Practices, LLC Best. Incorporating biomarker research for R&D success: Access and intelligence for achieving world-class excellence. Best Practices, LLC, 2004.

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S, Hulka Barbara, Wilcosky Timothy C, and Griffith Jack D, eds. Biological markers in epidemiology. Oxford University Press, 1990.

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Carlos, Kaski Juan, and Holt David W, eds. Myocardial damage: Early detection by novel biochemical markers. Kluwer Academic, 1998.

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Sensei, Iryō Wākushoppu (2010 Tokyo Japan). Sensei iryō: Wākushoppu hōkokusho. Kagaku Gijutsu Shinkō Kikō Kenkyū Kaihatsu Senryaku Sentā, 2011.

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Nela, Pivac, ed. Peripheral biological markers in alcoholism. Nova Science Publishers, 2008.

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Roine, Risto. Urinary dolichols as biological markers of alcoholism. [s.n.], 1988.

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Book chapters on the topic "Biochemical markers of transformation"

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Nhut, Duong Tan, Jaime A. Teixeira da Silva, C. R. Aswath, Bui Van Le, and K. Tran Thanh Van. "Biochemical and Molecular Markers in Programmed Plant Differentiation and Manipulation of the Morphogenetic Pathways in Tabacco and Lily by Using TCL Technique." In Thin Cell Layer Culture System: Regeneration and Transformation Applications. Springer Netherlands, 2003. http://dx.doi.org/10.1007/978-94-017-3522-3_6.

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Lee, Bun-Hee, and Yong-Ku Kim. "Biochemical Markers." In Understanding Suicide. Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-26282-6_13.

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Baak, Marleen A., Bernard Gutin, Kim A. Krawczewski Carhuatanta, et al. "Overtraining-Biochemical Markers." In Encyclopedia of Exercise Medicine in Health and Disease. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-540-29807-6_156.

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Wu, Alan H. B., and Robert G. McCord. "New Biochemical Markers for Heart Diseases." In Cardiac Markers. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4612-1806-7_17.

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Jensen, J. E. B., H. A. Sørensen, and O. H. Sørensen. "Biochemical Markers and Bone." In Management of Fractures in Severely Osteoporotic Bone. Springer London, 2000. http://dx.doi.org/10.1007/978-1-4471-3825-9_6.

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Wu, Alan H. B. "Introduction to Coronary Artery Disease (CAD) and Biochemical Markers." In Cardiac Markers. Humana Press, 1998. http://dx.doi.org/10.1007/978-1-4612-1806-7_1.

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Christenson, Robert H., and Hassan M. E. Azzazy. "Assessing Reperfusion and Prognostic Infarct Sizing with Biochemical Markers." In Cardiac Markers. Humana Press, 2003. http://dx.doi.org/10.1007/978-1-59259-385-9_4.

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Hampson, Geeta. "Biochemical Markers in Bone Diseases." In Radionuclide and Hybrid Bone Imaging. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/978-3-642-02400-9_5.

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Chu, T. M. "Biochemical Markers for Human Cancer." In Current Topics in Pathology. Springer Berlin Heidelberg, 1987. http://dx.doi.org/10.1007/978-3-642-71356-9_2.

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Blackwell, Penny, Ian Godber, and Nigel Lawson. "Biochemical Markers of Bone Turnover." In Clinical Trials in Osteoporosis. Springer London, 2002. http://dx.doi.org/10.1007/978-1-4471-3710-8_13.

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Conference papers on the topic "Biochemical markers of transformation"

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Yamadera, Keiji, and Michiharu Niimi. "Improved Ultimate Link without Markers for Projective Transformation." In 2024 Asia Pacific Signal and Information Processing Association Annual Summit and Conference (APSIPA ASC). IEEE, 2024. https://doi.org/10.1109/apsipaasc63619.2025.10849096.

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Chen, Joseph, Charles I. Fisher, M. K. Sewell-Loftin та W. David Merryman. "Calcific Nodule Morphogenesis by Aortic Valve Interstitial Cells: Synergism of Applied Strain and TGF-β1". У ASME 2011 Summer Bioengineering Conference. American Society of Mechanical Engineers, 2011. http://dx.doi.org/10.1115/sbc2011-53899.

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Calcific Aortic Valve Disease (CAVD) is the third most common cause of cardiovascular disease, affecting nearly 5 million people in the United States alone. It is now the most common form of acquired valvular disease in industrialized countries and will likely affect more individuals in the coming years as the prevalence increases with life expectancy. It is known that the progression of CAVD is closely related to the behavior of aortic valve interstitial cells (AVICs); however the cellular mechanobiological mechanisms leading to dysfunction remain unclear. Generally, CAVD is characterized by the formation of calcified AVIC aggregates with an apoptotic core. These aggregates increase the leaflet stiffness and impede normal valve function. Multiple studies have investigated the effects of various biochemical cues on this process, such as transformation growth factor β1 (TGF-β1), on the regulation of nodule formation [1]. Additionally, Yip et al revealed that matrix stiffness controls nodule formation in vitro, with stiffer substrates promoting apoptotic nodule formation, while compliant substrates generated nodules containing cells with osteoblast markers [2]. This suggests that matrix stiffness is involved in the regulatory mechanisms of nodule formation and may initiate different types of nodule formation (i.e. osteogenic vs. dystrophic). In the current study, we examined the synergistic role of strain and TGF-β1 in the generation of calcified nodules AVICs.
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Karlovits, Igor. "Lignocellulosic bio-refinery downstream products in future packaging applications." In 10th International Symposium on Graphic Engineering and Design. University of Novi Sad, Faculty of technical sciences, Department of graphic engineering and design,, 2020. http://dx.doi.org/10.24867/grid-2020-p2.

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The concept of efficient utilisation of renewable bio-based materials (biomass feedstock) is the driving force in the green transformation to a more sustainable and circular society. Biorefineries or biochemical platforms convert and utilise different sources of biomass into fuels and other beneficial derivates like fibres and other bio-based chemicals. These can be used as building blocks for many potentially useful applications. In this review, we shall describe the current state of the art and trends in the conversion of lignocellulosic feedstock into materials which can be primarily used in packaging applications. The three main constituents (cellulose, hemicellulose and lignin) are being re-engineered into new products with higher added value. The main goal of all these downstream products is that they do not compete with animal feed and food applications. The main downstream products of different kind of transformations are different natural fibres which can be further processed into micro or nano fibrillated state and used for a broad application of fields from ink, adhesive and packaging materials. Also, fibres and its derivates can be bonded successfully into bio-composites or fibre-based foams applications for the protective packaging applications. Hemicellulose, as a second most abundant component, has been researched for applications in adhesives and paper and paperboard coatings. Lignin which is currently utilised as an energy source for the paper industry, has been recently actively researched. Lignin-based biopolymers have a potential to be used in many different applications from additives in the barrier coatings on the packaging to active packaging and even as lignin-based foams. All these applications are currently in the development stages and cover niche market segments, but are expected to grow and to be used in future markets.
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Greifová, H., E. Tvrdá, P. Červeňanská, et al. "BIOCHEMICAL MARKERS OF INFLAMMATION IN DAIRY CATTLE." In XVIII INTERNATIONAL SCIENTIFIC CONFERENCE RISK FACTORS OF FOOD CHAIN 2017. Uniwersytet Pedagogiczny w Krakowie, 2017. http://dx.doi.org/10.24917/9788380840973.6.

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Maciel Campos Da Silva, Ana Sofia, Rita Enriquez, Joana Duarte, et al. "Biochemical markers as predictors of outcomes in COPD exacerbations." In ERS International Congress 2023 abstracts. European Respiratory Society, 2023. http://dx.doi.org/10.1183/13993003.congress-2023.pa3638.

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Gomez Punter, Rosa Mar, Rosa Maria Giron, Emma Vazquez, et al. "Biochemical Markers Of Bone Turnover In Adults With Cystic Fibrosis." In American Thoracic Society 2012 International Conference, May 18-23, 2012 • San Francisco, California. American Thoracic Society, 2012. http://dx.doi.org/10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a2810.

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Du, Shuyan, Xiangling Mao, Dikoma Shungu, and Paul Sajda. "Blind recovery of biochemical markers of brain cancer in MRSI." In Medical Imaging 2004, edited by J. Michael Fitzpatrick and Milan Sonka. SPIE, 2004. http://dx.doi.org/10.1117/12.534652.

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"Catalytically active bispecific antibodies – new biochemical markers of HIV/AIDS." In Bioinformatics of Genome Regulation and Structure/ Systems Biology. institute of cytology and genetics siberian branch of the russian academy of science, Novosibirsk State University, 2020. http://dx.doi.org/10.18699/bgrs/sb-2020-258.

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Zolotavina, M. L., and E. A. Gaidabura. "CORRELATION ANALYSIS OF THE MAIN BIOCHEMICAL MARKERS OF IN-FLAMMATION IN COVID-19." In NOVEL TECHNOLOGIES IN MEDICINE, BIOLOGY, PHARMACOLOGY AND ECOLOGY. Institute of information technology, 2022. http://dx.doi.org/10.47501/978-5-6044060-2-1.137-142.

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The article is devoted to determining the correlation between the biochemical parameters of the blood serum of patients with COVID-19. Concentrations of the main biochemical markers of inflammation at different stages of lung tissue damage by a new coronavirus infection with further correlation analysis of blood parameters were determined. The experiment of the study showed that there is a high correlation between the biochemical parameters of blood. Its sig-nificance helps to determine the sequence of the manifestation of biochemical markers of in-flammation and proves the mechanism of changes in the biochemical picture of blood in COVID-19, which we assume.
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Singh, S. P., and C. Murali Krishna. "Raman spectroscopy of oral tissues: correlation of spectral and biochemical markers." In SPIE BiOS, edited by Bernard Choi, Nikiforos Kollias, Haishan Zeng, et al. SPIE, 2014. http://dx.doi.org/10.1117/12.2052797.

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Reports on the topic "Biochemical markers of transformation"

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Nicholson, Ralph, Reuven Reuveni, and Moshe Shimoni. Biochemical Markers for Disease Resistance in Corn. United States Department of Agriculture, 1996. http://dx.doi.org/10.32747/1996.7613037.bard.

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The objective was to screen maize lines for their ability to express resistance based on biochemical traits. Cultivars were screened for retention of the hydroxamic acid DIMBOA and the synthesis of phenols (based on anthocyanin production) as markers for resistance. Lines were selected and inoculated with fungal pathogens (Exserohilum turcicum, Puccinia sorghi, Cochliobolus heterostraphus, Colletotricum graminicola.), and the Maize Dwarf Mosaic and Johnson Grass Mosaic viruses. Lines were screened in the field and greenhouse. Results showed that lines selected for augmented phenol synthesis do exhibit heightened levels of resistance to fungal pathogens. Isolation of mRNA followed by northern analyses for expression of A1 (dihydroflavanol reductase) and peroxidase confirmed that genes for these enzymes were turned on in response to inoculation of lines predicted to exhibit resistance. Peroxidase and b-1,3-glucanase were assayed in breeding lines having or lacking the se gene. A specific ionically-bound peroxidase isozyme and a b-1,3-glucanase isozyme were revealed in lines having the se gene. Data suggest that peroxidase and b-1,3-glucanase isozymes, may be considered as markers to identify resistance to E. turcicum in maize genotypes with the se gene.
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Hayes, Ronald L. Biochemical Markers of Brain Injury: An Integrated Proteomics-Based Approach. Defense Technical Information Center, 2005. http://dx.doi.org/10.21236/ada437666.

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Lockridge, Oksana. Biochemical Markers for Exposure to Low Doses of Organophosphorus Insecticides. Defense Technical Information Center, 2002. http://dx.doi.org/10.21236/ada408118.

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Lockridge, Oksana. Biochemical Markers for Exposure to Low Doses of Organophosphorus Insecticides. Defense Technical Information Center, 2003. http://dx.doi.org/10.21236/ada419631.

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Hayes, Ronald L. Biochemical Markers of Brain Injury: An Integrated Proteomics Based Approach. Defense Technical Information Center, 2004. http://dx.doi.org/10.21236/ada425658.

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Akhverdyan, Y., L. Seewordova, Y. Polyakova, B. Zavodovsky, E. Papichev, and V. Pavlovskaya. BIOCHEMICAL MARKERS OF BONE REMODELING IN PATIENTS WITH RHEUMATOID ARTHRITIS. "PLANET", 2019. http://dx.doi.org/10.18411/978-5-907192-54-6-2019-xxxvi-19-23.

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Hayes, Ronald L. Biochemical Markers of Brain Injury: An Integrated Proteomics-Based Approach. Defense Technical Information Center, 2011. http://dx.doi.org/10.21236/ada561092.

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Hayes, Ronald L. Biochemical Markers of Brain Injury: An Integrated Proteomics-Based Approach. Defense Technical Information Center, 2007. http://dx.doi.org/10.21236/ada474912.

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Wiles, Connor. Frozen, Old, or New? Comparing Biochemical Markers and Tissue Oxygenation in Transfused Blood. Portland State University Library, 2014. http://dx.doi.org/10.15760/honors.34.

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zhong, xiaoling. Diagnostic Efficacy of Biochemical Markers in ADHD: A Systematic Review and Meta-Analysis. INPLASY - International Platform of Registered Systematic Review and Meta-analysis Protocols, 2025. https://doi.org/10.37766/inplasy2025.7.0060.

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