Dissertations / Theses on the topic 'Blocked trials'

En tant qu'un des plus grands bassins sédimentaires du bloc de Chine du Sud, le bassin de Nanpanjiang a attiré une grande attention de la communauté géologique depuis de longtemps. Après plusieurs années de recherche, il reste encore de grand débats sur i) la provenance du bassin, ii) l'âge du changement de régime extension à compression, iii) le type de bassin et son contexte géodynamique. Dans cette thèse, nous avons conduit une étude pluri-disciplinaire incluant l'analyse des faciès sédimentaires et leur distribution géographique, paléocourants, spectres des minéraux lourds et leur geochimie, la géochronologie U-Pb sur zircon et baddeléyite, et le magnétisme des roches pour reconstrurier l'evolution de ce bassin. Les résultats indiquent un trois-étapes évolution. i) durant la période du Permien supérieur au début du Trias, la diabase mise en place 269Ma annonce l'ouverture du bassin, l'environnement sédimentaire est devenu plus profond. ii) durant la période du stade tardif du Trias inférieur (~ 245 Ma) au Trias moyen, à cause des influences de l'orogène Xuefengshan et de l'orogène d'Indochine situées à l'est et au sud du bassin, le bassin a évolué en bassin d'avant-pays. La diabase arrête sa mise en place durant cette période. Les analyses de détritus et de paléo-courants indiquent que durant cette période, les provenances de la partie est et de la partie sud du bassin étaient respectivement l'orogène Xuefengshan et l'orogène Indochinois. iii) la fin du Tirassique, la profondeur de l'environnement sédimentaire a fortement diminué, indiquant que le bassin a commencé à se rétrécir sous l'effet de la compression de l'orogène Xuefengshan et de l'orogène d'Indochine<br>Ranks as the largest sedimentary basin in the South China during the Triassic, The Nanpanjiang basin attracts a large attention of the geology community for a long time. After many years study, there still exist several debates on i) the provenance of the sedimentary detritus, ii) the time of the change of the tectonic regime from extension to compression, iii) the type of the basin and its geodynamic background. In this thesis, a multidisciplinary study including analysis of sedimentary facies, paleo-current, frame work detritus mode, heavy mineral combinations and their geochemistry feature, rock magnetism and Zircon-baddeleyite isotopic dating on diabase was conducted to rebuild the evolution of the basin.The results show a three-stage evolution, i) during the Late Permian to the Early Triassic, the 269Ma diabase intruding into the basin announces the opening of the basin, the sedimentary environment became deeper. ii) During the late stage of the Early Triassic (~245 Ma) to the Middle Triassic, owing to the influences of the Xuefengshan orogen and the Indochina orogen which are located to the east and south of the basin, the basin evolved into a foreland basin. The diabase ceased emplacement in this period. The detritus and paleo-current analysis indicate that during this stage, the provenances of the East part and the South part of the basin were Xuefengshan Orogen and Indochina Orogen respectively. iii) During the Late Tirassic, the depth of the sedimentary environment decrease drasticly, indicating that the basin began to shrink owing to the compression of the Xuefengshan Orogen and the Indochina Orogen

People often have very little knowledge about the impact of unsustainable human population growth on the environment and social well-being especially in developing countries. Therefore, an efficient method should be explored in order to educate, and if possible, to convince the members of the public to realize the environmental and social problems caused by the unsustainable population growth. Digital Game-Based Learning (DGBL) has been highlighted by some studies as an innovative tool for learning enhancement. While only a handful of studies have scientifically evaluated the impact of DGBL on knowledge outcomes, the approach is an attractive tool to increase knowledge and motivate engagement with environmental issues surrounding population growth because of its potential to improve learners’ motivation and engagement thereby compared to traditional learning approaches. Therefore, the three primary research questions for this study are: 1) "Can a single-player digital game be an appropriate and attractive learning application for the players to gain insight about the relationship between the growing human population and the environmental issues?" 2) "How can we design environmental games for the players to gain insights about the relationship between the growing human population and the environmental issues via playing a game?" and 3) "What are the obstacles preventing the players from adapting environmental knowledge obtained from the learning mediums into the real-life?" To inform the development of an efficacious DGBL game to impact learning outcomes, critical reviews of environmental issues related to population growth as well as critical reviews of commercial and serious environmental games in terms of their educational and motivational values were undertaken in this study. The results of these critical reviews informed the development of a Guideline for Environmental Games (or GEG). The GEG was developed by combining the engaging game technology with environmental learning and persuasion theories. The GEG was then used to inform the development of a prototype game called THE GROWTH; a single-player, quiz-based, city-management game targeting young adolescents and adults. Multiple evaluation methods of the game were used to answer the three key research questions mentioned earlier. These methods included: 1) The Randomized Controlled Trial approach (RCT) where the participants were systematically divided into the experimental and the control group respectively and their knowledge scores (quantitative data) compared and analyzed, 2) The participants’ abilities to recall and describe the environmental and well-being issues were collected and analyzed qualitatively using The Content Analysis method (CA) and, 3) The participants’ overall feedback on the learning mediums was collected and analyzed to evaluate the motivational values of THE GROWTH itself. To this end, THE GROWTH was evaluated with 82 Thai-nationality participants (70 males and 12 females). The results showed that participants assigned to play THE GROWTH demonstrated greater environmental and social-well-being knowledge related to population growth (F(1,40) = 43.86, p = .006) compared to the control group participants assigned to a non-interactive reading activity (consistent with material presented in THE GROWTH). Furthermore, participants who played THE GROWTH recalled on average more content presented in the game when compared to participants who were presented with similar content in the reading material (t (59) = 3.35, p = .001). In terms of level of engagement, the study suggested that participants assigned to the game were more engaging with their learning medium on average when compared to participants assigned to the non-interactive reading activity. This is evidenced by the longer time participants spent on the task, the activity observed from participants’ recorded gameplay, and their positive responses in the survey. The semi-structured interviews used in this study highlighted the participants’ attitudes towards the environmental, social, and technological issues. Although the participants’ perceived behavioural intention towards the environmental commitments were not statistically differed between the two study group, their responses still provide some evidences that leaps may occur from the learning mediums to the real-world context. Furthermore, these responses can be valuable evidences for the policy makers and for the future development of environmental serious games. Overall, the results suggested that digital environmental games such as THE GROWTH might be an effective and motivational tool in promote the learning about sustainable population size, the environment, and the social well-being. The game’s ability to convince the participants to change towards sustainable lifestyles, however, might be subjected to the future research and other real-world circumstances such as the governmental and public supports. In summary, the research in this thesis makes the following contributions to knowledge: • The Guideline for Environmental Games (GEG) contributes to knowledge about making theoretically-based environmental games. It has particular significance because the guideline was validated by demonstrating learning improvements in a systematic randomized controlled trial. • The use of Multi-Strategy Study Design where multiple systematic evaluation methods were used in conjunction to provide conclusive findings about the efficacy of DGBL to impact outcomes. • THE GROWTH itself is a contribution to applied research as an example of an effective DGBL learning tool.

Une élévation majeure de la charge mutationnelle (hypermutation) est observée dans certains gliomes. Néanmoins, les mécanismes de ce phénomène et ses implications thérapeutiques notamment concernant la réponse à la chimiothérapie ou à l'immunothérapie sont encore mal connus. Sur le plan du mécanisme, une association entre hypermutation et mutations des gènes de la voie de réparation des mésappariements de l'ADN (MMR) a été rapportée dans les gliomes, cependant la plupart des mutations MMR observées dans ce contexte n'étaient pas fonctionnellement caractérisées, et leur rôle dans le développement d’hypermutation restait de ce fait incertain. De plus, l'impact de l'hypermutation sur l'immunogénicité des cellules gliales et sur leur sensibilité au blocage des points de contrôles immunitaires (par exemple par traitement anti-PD-1) n’est pas connu. Dans cette étude, nous analysons de manière exhaustive les déterminants cliniques et moléculaires de la charge et des signatures mutationnelle dans 10 294 gliomes, dont 558 (5,4%) tumeurs hypermutées. Nous identifions deux principales voies responsables d'hypermutation dans les gliomes : une voie "de novo" associée à des déficits constitutionnels du système MMR et de la polymérase epsilon (POLE), ainsi qu'une voie "post-traitement", plus fréquente, associée à l'acquisition de déficits MMR et de résistance secondaire dans les gliomes récidivant après chimiothérapie par temozolomide. Expérimentalement, la signature mutationnelle des gliomes hypermutés post-traitement (signature COSMIC 11) était reproduite par les dommages induits par le témozolomide dans les cellules MMR déficientes. Alors que le déficit MMR s'associe à l'acquisition de résistance au témozolomide, des données cliniques et expérimentales suggèrent que les cellules MMR déficientes conservent une sensibilité à la nitrosourée lomustine. De façon inattendue, les gliomes MMR déficients présentaient des caractéristiques uniques, notamment l'absence d'infiltrats lymphocytaires T marqués, une hétérogénéité intratumorale importante, une survie diminuée ainsi qu’un faible taux de réponse aux traitements anti-PD-1. De plus, alors que l'instabilité des microsatellites n'etait pas détectée par des analyses en bulk dans les gliomes MMR déficients, le séquençage du génome entier à l'échelle de la cellule unique de gliome hypermuté post-traitement permettait de démontrer la presence de mutations des microsatellites. Collectivement, ces résultats supportent un modèle dans lequel des spécificités dans le profil mutationnel des gliomes hypermutés pourraient expliquer l’absence de reconnaissance par le système immunitaire ainsi que l’absence de réponse aux traitements par anti-PD-1 dans les gliomes MMR déficients. Nos données suggèrent un changement de pratique selon lequel la recherche d’hypermutation par séquençage tumoral lors de la récidive après traitement pourrait informer le pronostic et guider la prise en charge thérapeutique des patients<br>High tumor mutational burden (hypermutation) is observed in some gliomas; however, the mechanisms by which hypermutation develops and whether it predicts chemotherapy or immunotherapy response are poorly understood. Mechanistically, an association between hypermutation and mutations in the DNA mismatch-repair (MMR) genes has been reported in gliomas, but most MMR mutations observed in this context were not functionally characterized, and their role in causing hypermutation remains unclear. Furthermore, whether hypermutation enhances tumor immunogenicity and renders gliomas responsive to immune checkpoint blockade (e.g. PD-1 blockade) is not known. Here, we comprehensively analyze the clinical and molecular determinants of mutational burden and signatures in 10,294 gliomas, including 558 (5.4%) hypermutated tumors. We delineate two main pathways to hypermutation: a de novo pathway associated with constitutional defects in DNA polymerase and MMR genes, and a more common, post-treatment pathway, associated with acquired resistance driven by MMR defects in chemotherapy-sensitive gliomas recurring after temozolomide. Experimentally, the mutational signature of post-treatment hypermutated gliomas (COSMIC signature 11) was recapitulated by temozolomide-induced damage in MMR-deficient cells. While MMR deficiency was associated with acquired temozolomide resistance in glioma models, clinical and experimental evidence suggest that MMR-deficient cells retain sensitivity to the chloroethylating nitrosourea lomustine. MMR-deficient gliomas exhibited unique features including the lack of prominent T-cell infiltrates, extensive intratumoral heterogeneity, poor survival and low response rate to PD-1 blockade. Moreover, while microsatellite instability in MMR-deficient gliomas was not detected by bulk analyses, single-cell whole-genome sequencing of post-treatment hypermutated glioma cells demonstrated microsatellite mutations. Collectively, these results support a model where differences in the mutation landscape and antigen clonality of MMR-deficient gliomas relative to other MMR-deficient cancers may explain the lack of both immune recognition and response to PD-1 blockade in gliomas. Our data suggest a change in practice whereby tumor re-sequencing at relapse to identify progression and hypermutation could inform prognosis and guide therapeutic management

Dans un contexte politique, économique et culturel différent, la justice constitutionnelle se développe en Égypte et en France. D’un point de vue purement juridique, le contrôle de constitutionnalité des lois s’exerce dans les deux pays selon une procédure différente. Le développement du contrôle de constitutionnalité des lois dans les deux pays avait, toutefois, pour effet de reproduire progressivement des rapprochements quant au contrôle de constitutionnalité des lois. L’Égypte établit en 2005 un mécanisme a priori sur la constitutionnalité des certaines catégories des lois électorales. De son côté, la France finit en 2008 par inaugurer un mécanisme du contrôle a posteriori (la QPC). Cette thèse propose de montrer que la justice constitutionnelle dans les deux pays s’appuie sur les mêmes fondements, tant sur un plan matériel que formel. Le contrôle exercé par la Cour constitutionnelle dans chacun des deux pays peut être considéré comme une application du modèle européen de justice constitutionnelle adaptée aux différentes données politiques, juridiques, économiques et culturelles de chacun de deux pays<br>In the political, economic, and cultural status quo, constitutional justice has been developed in both Egypt and France. From the legal perspective, it has been realized that various difference between both countries within the mechanism of the constitutional review of laws. Recently, the development of this legal issue in both countries leads to some of similarities between the mechanism in both Egypt and France, especially on the procedural level. Egypt adopted the same French scheme in 2005 with respect to some of the election laws. Further, France adopted the same constitutional review as Egypt via subordinate claim in 2008. But that does not mean that the constitutional review in both countries include only the procedural levels but also the main principle of the legal constitutional reviews in Egypt and France

博士<br>中山醫學大學<br>醫學研究所<br>104<br>Objective：We use the single gastrocnemius muscle to treat ankle plantarflexor spasticity in hemiplegic patients. The objective is to compare the efficacy and electrophysiologic changes after intramuscular injection of botulinum toxin type A and muscular branch block of the tibial nerve with phenol, and to establish the efficient spasticity treatment strategy. Methods and Materials：Thirty hemiplegic patients with ankle plantarflexor spasticity were recruited. They were randomly assigned to group 1 which underwent gastrocnemius intramuscular botulinum toxin type A injection and group 2 which underwent percutaneous muscular branch block of the tibial nerve with phenol. Informed consent was signed before the entry to this study. We measured physical, electrophysiological and 6 minute walking test for these two groups before and two, four, eight, and twelve weeks after the time of injection. Group 2 also received post-injection measurements on the same day of injection to understand the immediate phenol nerve blocking effect. Results：Twenty nine patients fulfilled this study. There were 15 in group 1and 14 in group 2. The immediate phenol blocking effect in group 2 showed significant improvement in Modified Ashworth scale (MAS), Modified Tardieu scale (MTS) and 6 minute walking test (p＜0.05). The outcome measure, MAS and MTS, which were significantly reduced in the all time periods after the time of injection but there was no difference between these two groups. Significantly larger R1(quick velocity) angle was measured in both knee flexion and extension in all post-injection time periods (p<0.0001). Walking step counts improved significantly in two, eight and twelve weeks after the time of injection (p=0.001). Step length and walking speed also increased significantly in these two groups. There was no statistical difference in compound muscle action potential (CMAP) of the adductor hallucis and soleus muscles, H latency, Hmax and HM ratio before and after injection and in these two groups. CMAP of the lateral gastrocnemius muscle reduced significantly at all post-injection time periods (p=0.001). In the medial gastrocnemius muscle, the CMAP reduced significantly in two and four weeks after the time of injection p=0.026). In the adverse effect, there was three patients (10.3%) in group 1complained of transient muscle weakness and one patient (3.4%) in group 2 complained of pain over the popliteal and calf area. Conclusion and Suggestion：Both intramuscular botulinum toxin type A injection and percutaneous muscular branch of the tibial nerve block with phenol can significantly reduce ankle plantarflexor spasticity caused by the gastrocnemius muscle hypertonicity. These two methods improve Modified Ashworth scale, Modified Tardieu scale and walking ability as well. They are both well-tolerated procedures with few adverse effects. We suggest percutaneous muscular branch of the tibial nerve block with phenol is a safe and cost-effective way for the spasticity management.

Triarylborane Functionalized Dicyanovinyl and Acetylacetone Based Molecular Platforms: Building Blocks for Multiple Anion Sensors and Efficient Phosphorescence Emitters The main objective of this thesis is to design a simple strategy for triarylborane based multiple anion sensors and development of triarylborane incorporated phosphorescent metal complexes. The thesis consists of eight chapters and the contents of each chapter are given below. Chapter 1 This chapter gives a general introduction to recent advances relevant to the theme of the thesis. A review of the fundamental characteristics of triarylboranes and their applications in various fields such as chemical sensors and optoelectronics is presented. Advances in boron chemistry in the areas such as anion sensors, solid state emissive and phosphorescence materials are discussed in detail. The scope of the thesis is outlined at the end of the chapter. Chapter 2 The second chapter deals with the general experimental techniques and synthetic procedures followed in this thesis. Chapter 3 This chapter deals with a rational design strategy for differential identification of fluoride and cyanide ions using TAB based sensors. In general, most of the triarylboranes give similar optical responses towards fluoride and cyanide ions as they follow similar sensing mechanism. In order to circumvent this problem, two TAB-DCV conjugates (1 and 2) are designed and synthesised. The DCV unit is highly specific for cyanide ion owing to the presence of electrophilic carbon center. Probes 1 and 2 differ in steric crowding around the boron center. The less crowded boron center in 1 binds with fluoride as well as with cyanide ions giving similar optical response (luminescence is quenched in presence of F¯ and CN¯). In the case of 2, selectivity of boron center towards fluoride is tuned by increasing the steric crowding around the boron unit. The dicyanovinyl unit acts as selective sensing site for cyanide ions. As a result, 2 gives different fluorogenic response towards the anions F¯ and CN¯ which were considered as interfering anions in TAB based sensor chemistry. Thus, a modular design principle is developed for differential identification of fluoride and cyanide ions using TAB. Chapter 4 In this chapter, detailed photophysical studies of TAB-amine-DCV conjugates and colorimetric discrimination of fluoride and cyanide ions are discussed. Presence of amine based donor between the two electron deficient sites enhances the electronic conjugation in 3−5. Since there are two different acceptor sites with a common donor, two distinct charge transfer transition bands are observed in the visible region of electromagnetic spectrum. The absorption and emission spectra of these compounds show pronounced sensitivity to solvent polarity, signifying large excited state dipolmonents. Anion binding studies confirms that these compounds are highly selective towards fluoride and cyanide ions. Fluoride ions selectively interact with boron center and block the corresponding charge transfer transition thereby leading to a distinct colour change which is observable by naked eye. On the other hand, cyanide interacts with boron as well as DCV unit and blocks both the charge transfer transitions which results in disappearance of colour. Hence, compounds 4 and 5 exhibit different colorimetric signals for fluoride and cyanide ions. Since the absorption bands of 3 do not fall in the visible region, it does not show any colorimetric response towards the aforementioned anions. The anion sensing mechanisms are established by 1H, and 19F NMR studies. Chapter 5 This chapter presents a systematic study of the effect of length of π-electronic conjugation on the optical properties and anion sensing abilities of a series of TAB-oligothiophene-DCV conjugates (6−8). Their absorption as well as emission bands undergo redshift upon increasing the number of thiophene units between TAB and DCV units as the π-electronic conjugation in 6−8 is greatly dependent on the number of thiophene units. Their fluorescence emission is highly sensitive to solvent polarity. In the case of 6, the emission band undergoes a redshift with reduced intensity. In the case of 7 the emission band undergoes a redshift but the intensity is not affected by solvent polarity. In the case of 8, the emission band undergoes redshift with enhanced intensity in polar solvents. Interestingly, 7 and 8 show solvent viscosity dependent fluorescence. Structural reorganisation is restricted in viscous medium and results in enhanced emission for 7 and 8. Further, these compounds exhibit selective response towards the fluoride and cyanide ions with different colorimetric responses. Test strips made up of probes 7 and 8 have potential application in identifying fluoride and cyanide ions in aqueous medium. Chapter 6 This chapter describes synthesis and optical characterisation of triarylborane incorporated acetylacetone (acacH) ligands (9, 10) and their borondifluoride complexes (11, 12). AcacH ligands and BF2 complexes show solvent dependent emission phenomena due to the involvement of charge transfer transition. Their optical properties are highly dependent on molecular conformations. Complex with duryl spacer (12) exhibits more red shifted emission in polar solvents due to the enhanced charge transfer transition facilitated by twisted rigid geometry. In presence of fluoride and cyanide ions, the borondifluoride complexes are not stable. The anions concomitantly interact with tricoordinate boron as well as acac-BF2 unit to give rise to complex pattern of photoluminescence spectral changes during the titration experiment. The binding pathway and the possible species involved are established with the help of 1H, 19F and 11B NMR spectral studies in presence of the anions. Complexes 11 and 12 act as selective chemodosimetric sensors for fluoride and cyanide ions. Chapter 7 In this chapter, the synthesis and optical characterisations of triarylborane conjugated cyclometalated platinum complexes are discussed. A series of square planar platinum complexes are synthesised with different cyclometalating ligands. Complexes (13−18) exhibit a range of luminescence from green to red in solution as well as in the solid state. Their emission intensities are highly sensitive towards atmospheric oxygen suggesting that they originate from a triplet excited state. A maximum of 85% quantum yield is observed for complex 15 in solution state while complex 14 showed a maximum of 58% quantum yield in solid state. Complexes with rigid molecular conformation (14, 16 and 18) showed higher luminescence quantum yield than those having phenyl spacer (13, 15 and 17). The sterically encumbered boryl (-BMes2) group significantly reduces π-π stacking between the square planar entities. Thus, complexes 13−18 show bright luminescence in solid state compared to model complexes without boryl group. The effect of Lewis acidic boron center on luminescence behaviour is explored by fluoride binding studies. Chapter 8 This chapter is divided into two parts. Part-I describes the synthesis and optical characterisation of triarylborane conjugated cyclometalated iridium complexes (19−24). They are brightly luminescent in solution state with high sensitivity towards atmospheric oxygen. Complex 20 shows a highest quantum yield of 91%. Interestingly, under ambient atmospheric conditions, they exhibit a rare type of dual emission. Life time data suggest that the lower energy emission band originates from cyclometalated iridium based triplet excited state while higher energy emission band originates from boryl ased singlet excited state. Fluoride binding at the boron site results in luminescence quenching; evidently, tri-coordinate boron has a major contribution to the luminescence features of these iridium complexes. Part-II deals with synthesis of triarylborane conjugated pyrazole ligand (25) and its binuclear iridium complexes (26−28) in which two iridium centers are bridged by hydroxo as well as pyrazolato ligands. These binuclear iridium complexes exhibit higher luminescence quantum yield than TAB-acac-Iridium complexes (mononuclear complexes; part I). Binding of fluoride ions at the boron center has a minor impact on their luminescence nature. High sensitivity of their luminescence towards atmospheric oxygen indicates the involvement of triplet excited state in their emission process.

Le syndrome douloureux régional complexe (SDRC) est un trouble neurologique qui se caractérise par des douleurs intenses, des troubles vasomoteurs, sudomoteurs, moteurs et trophiques, accompagnés d’un œdème au niveau du membre affecté. Malgré la présence de peu de données en faveur, à cause de l’absence d’un traitement clé du SDRC, le blocage sympathique a été utilisé depuis de nombreuses années pour traiter ce syndrome. Objectif Le but principal de ce projet est d’étudier l’effet antalgique de la néostigmine utilisée comme adjuvant à la bupivacaïne lors d’un bloc stellaire dans le traitement du syndrome douloureux régional complexe du membre supérieur. Méthodes Il s’agit d’une étude pilote, randomisée en double insu. L’intensité de la douleur a été évaluée en utilisant l’échelle numérique. La force de préhension aux deux mains a été estimée par dynamométrie de Jamar. La dextérité fine des doigts a été mesurée par le « Purdue Pegboard Test ». L’œdème au niveau de la main a été déterminé par la volumétrie. Le questionnaire « SF-36 » a été utilisé afin de déterminer l’homogénéité des échantillons. Résultats Notre étude a eu des difficultés à établir l’efficacité de la thérapie par bloc stellaire dans le traitement du syndrome douloureux régional complexe. Conclusion Notre recherche n’a pu prouver l’hypothèse que le traitement de la douleur dans le SDRC du membre supérieur par un bloc stellaire est plus efficace quand l’action de l’anesthésique local est potentialisée par l’ajout de la néostigmine.<br>Complex regional pain syndrome (CRPS) is a neurological disorder characterized by severe pain, vasomotor, sudomotor, motor and trophic changes, accompanied by a swelling in the affected limb. Despite the limited data on his efficiency, in the absence of a definite curative treatment of the CRPS, sympathetic blocks have been used for years to treat the syndrome. Objective The main purpose of this project was to investigate the analgesic effect of neostigmine used as an adjuvant to the local anaesthetic bupivacaine in stellate ganglion blockade, in treating CRPS of the upper limb. Methods This was a pilot, randomized, double-blind study. The intensity of the pain was evaluated using a numeric scale. Grip strength in both hands was estimated by Jamar dynamometry. Fine finger dexterity was measured by the "Purdue Pegboard Test." The swelling in the hand was determined by volumetry. The questionnaire "SF-36" was used to determine the homogeneity of the samples in terms of quality of life assessment. Results Our study had difficulties in establishing the efficiency of stellate ganglion blockade in the treatment of complex regional pain syndrome. Conclusion This research project has not been able to prove that the pain treatment in upper limb CRPS by means of stellate ganglion blockade is more effective when the action of the local anesthetic is potentiated by the addition of neostigmine.