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Dissertations / Theses on the topic 'Cascade Reactions'

Author: Grafiati

Published: 4 June 2021

Last updated: 25 July 2025

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1

Dumrongchai, Nuethip. "Palladium Catalyzed Multicomponent Cascade Reactions." Thesis, University of Leeds, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.487516.

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This Thesis is divided into three parts: Introduction (Chapter 1), Result and Discussion (Chapter 2) and Experimental (Chapter 3). The Introduction (Chapter 1) provides a review of the recent literature relating to the 1,3dipolar cycloaddition reactions. ItÃ‚Â· covers nitrones, azomethine ylides and azomethine imines. The Result and Discussion. section (Chapter 2) deals with the author's work which is . concerned with developing four novel multicomponent cascade reactions. These are (i) a 3- component cascade involving bifunctional aryl halide! Michael acceptors, allene and arriine or sulphona

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2

Pocock, Ian. "Novel cascade aryne-capture/rearrangement reactions." Thesis, University of Huddersfield, 2014. http://eprints.hud.ac.uk/id/eprint/23743/.

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Arynes are reactive intermediates that have been an academic curiosity for over a century. A recent renaissance of interest in the chemistry of these intermediates can be traced back to the development of ortho-(silyl)aryl triflates as aryne precursors. The application of aryne chemistry outside academia has been precluded by the expense and laborious preparation of these precursors. Diphenyliodonium-2-carboxylate has been shown to be a stable and inexpensive benzyne precursor, however application has been limited due to the high temperature (>160 ºC) and long reaction times required to genera

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3

Demircan, Aydin. "Cascade reactions involving a furan core." Thesis, University of Sussex, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.297561.

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4

Amjad, Ê¿AliÌ„. "Cobalt-mediated cascade cyclisation reactions in synthesis." Thesis, University of Nottingham, 1993. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.357981.

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5

Too, Heng Kwee Marie Kathleen Sien Kiow. "Glycomimetics and peptidomimetics via catalytic cascade reactions." Thesis, University of Leeds, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.405741.

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6

Annis, Michael Colin. "Free radical cascade reactions involving furan rings." Thesis, University of Sussex, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.394991.

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7

Yap, Aaron J. "Hydrogenolysis, hydrogenation and nanoencapsulation in cascade reactions." Thesis, The University of Sydney, 2012. https://hdl.handle.net/2123/29153.

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Catalytic nanoreactors, prepared by the Layer-by-Layer encapsulation of zeolite H-Beta, were used in the dynamic kinetic resolution (DKR) of 1-phenylethanol and 1-indanol. Yields for both alcohols were clearly above 50%, with ee’s over 85%, indicating successful protection of the pH-sensitive enzyme, candida antarctica lipase B, from the acidic zeolite. Attention proceeded to the DKR of amines, which can involve the undesired hydrogenolysis reaction during the racemisation step. Thus, the phenomenon of hydrogenolysis was investigated. The hydrogenolysis of various amines, imines, and

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8

Double, Philip John. "Acyl radical cascade reactions : the synthesis of azasteroids." Thesis, University of Nottingham, 1998. http://eprints.nottingham.ac.uk/27769/.

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Our work has been concerned with the synthesis of azasteroid ring systems, utilising acyl radical cascade reactions. Chapter 1 comprises an overview of published work relevant to our studies: an analysis of steroid biosynthesis and synthesis; a review of the use of azasteroids, their biological activity and current synthetic techniques in azasteroid formation. This initial chapter also includes an introduction to published work in the area of nitrogen heterocycle synthesis using radical reactions and finally the use of acyl radicals in synthesis, particularly cascade reactions. Chapter 2 start

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9

Chaudhry, Sofia Javid. "Application of statistics and robotics to cascade reactions." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.551229.

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My thesis is composed of four themed sections: (1) The introduction reviews the Prins reaction, focusing mainly on the Prins condensation-cyclisation of homoallylic alcohols with aldehydes giving substituted tetrahydropyrans. This section also briefly reviews the Prins reaction giving dihydropyrans and the aza-Prins reaction giving piperidines and dihydropiperidines. (2) The results and discussion section details the author's own work and is further divided into two parts. The first part describes the synthesis of novel homoallylic alcohols and bis-homoallylic alcohols from Pd(O)/ln(O) mediate

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10

Boehm, Haydn M. "Tandem radical cascade cyclisation reactions in steroid synthesis." Thesis, University of Nottingham, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.364673.

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11

Heffernan, Stephen John. "The development of novel gold-catalysed indole cascade reactions." Thesis, University of Bath, 2012. https://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.557812.

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Divided into three distinct research areas, this thesis investigates the synthetic utility of enynones and ynamides towards the formation of biologically relevant structures. The first volume of work (Chapter 2) describes the gold-catalysed double alkylation of indole by enynones. The [6,5,7]-tricycles formed in this reaction are generally provided in excellent yield with complete regioselectivity. Optimisation of the procedure, a thorough substrate investigation, and mechanistic insights are discussed within. The gold-catalysed rearrangement of ynamido esters is described in Chapter 3. Follow

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12

Naoe, Saori. "Synthesis of Fused-Ring Compounds through Gold-Catalyzed Cascade Reactions." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215495.

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13

Qureshi, Ashfaq M. "A study of the cascade photochemical reactions of substituted maleimides." Thesis, University of Bristol, 2007. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.443665.

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14

Capaccio, Vito. "Enantioselective construction of new heterocyclic scaffolds via organocatalyzed cascade reactions." Doctoral thesis, Universita degli studi di Salerno, 2019. http://elea.unisa.it:8080/xmlui/handle/10556/4253.

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2017 - 2018<br>Chirality plays a vital role in human daily life. After the famous but tragic case regarding the Thalidomide, Food and Drug Administration (FDA) gave a guide in relation to the submission of new drug applications... [edited by Author]<br>XXXI ciclo

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15

LURIDIANA, ALBERTO. "Synthesis of high-value small molecules through new cascade reactions." Doctoral thesis, Università degli Studi di Cagliari, 2021. http://hdl.handle.net/11584/314052.

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Providing non-traditional disconnections has been recently highlighted as one of the “Key messages for organic chemistry when it comes from drug discovery” by scientists from GSK, Pfizer, and AstraZeneca. Apart from the possibility to unlock the access to previously unattainable chemical matter, the establishment of a novel synthetic approach could furnish new solutions in terms of cost, safety, eco-sustainability and time-consuming of a synthetic process. In the realm of ideal synthesis, cascade reactions are well known for their efficiency in building up molecular complexity starting from si

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16

Ross, Adam. "Novel routes to, and reactions of, cyclopropanes." Thesis, Loughborough University, 2014. https://dspace.lboro.ac.uk/2134/16315.

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An array of different cyclopropanes have been synthesised, including the structurally simple 1-phenylcyclopropanol. These were synthesised in yields upwards of 60%, using the well published Kulinkovich reaction. From 1-phenylcyclopropanol, variations of the cyclopropane core structure were synthesised, creating species ideal for palladium cross coupling reactions, such as 1-phenylcyclopropyl methanesulfonate and 1-phenylcyclopropyl 4-methylbenzenesulfonate. These were formed in 50 and 60% yield respectively. Once obtained these cyclopropanes were used to perform Suzuki cross coupling reactions

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17

Lo, Kai-yip, and 羅啟業. "Synthesis of aza-bicyclic compounds via palladium-catalyzed cascade cyclization reactions." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2012. http://hub.hku.hk/bib/B47849691.

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A palladium-catalyzed oxidative cascade cyclization reaction has been developed to prepare pyrrolizidine and indolizidine derivatives from simple aliphatic alkenyl amides 2.1ak in one step in moderate to good yields, using Pd(TFA)2 as the catalyst and molecular oxygen (1 atm) as a green oxidant. This cascade cyclization can also proceed for ring-containing unsaturated amides 2.1ln to afford azatricyclic systems. Palladium(II)-catalyzed dehydrohalogenation cascade cyclization reactions have been developed to synthesize polycyclic pyrrolizidine derivatives from iodoalkenylanilides 4.1ai

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18

Jones, Daniel Ross. "Cascade cyclisation reactions and their application toward the synthesis of lactonamycin." Thesis, Imperial College London, 2018. http://hdl.handle.net/10044/1/59356.

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The lactonamycins represent a class of natural products which possess significant biological activity with high potencies in cancer cell lines and against multi-drug resistant strains of bacterial infections. Here, a cascade cyclisation, developed in the Parsons group, has been used in the synthesis of the pentacyclic core of lactonamycin. The thermal cyclisation of an ene-diyne allows for a transition metal free synthesis of five of the six rings of lactonamycin in ten synthetic steps. Studies on the functionalisation of the pentacyclic core of lactonamycin have also been undertaken. A propos

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19

Pelletier, Sophie Marie-Clémentine. "One-pot nitro-Mannich cascade reactions : new methodologies and synthetic applications." Thesis, University of Oxford, 2011. http://ora.ox.ac.uk/objects/uuid:283641bf-bb4e-48a8-8a28-2e048b8c4ea6.

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Pyrrolidine and pyrrolidinone rings are common motifs found in many biologically active natural products and drugs. Accordingly, our work focuses on the development of new methodologies for their one-pot synthesis. An efficient diastereoselective nitro-Mannich / lactamisation reaction cascade of methyl 3-nitropropanoate with cyclic and acyclic imines for the direct preparation of trans-monocyclic and fused tricyclic pyrrolidinone derivatives was developed. The reaction is easy to perform, broad in scope and tolerates a wide variety of functional groups. For the monocyclic methodology, 28 examp

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20

LIN, PENG. "Enzyme cascade reactions on 3D DNA scaffold with dynamic shape transformation." Doctoral thesis, Kyoto University, 2021. http://hdl.handle.net/2433/265209.

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京都大学<br>新制・課程博士<br>博士(エネルギー科学)<br>甲第23437号<br>エネ博第424号<br>新制||エネ||81(附属図書館)<br>京都大学大学院エネルギー科学研究科エネルギー基礎科学専攻<br>(主査)教授森井孝, 教授佐川尚, 教授片平正人<br>学位規則第4条第1項該当<br>Doctor of Energy Science<br>Kyoto University<br>DFAM

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21

Liu, Xiaoling. "Polymeric Multicompartmentalized Systems Mimicking Artificial Cells for Controllable Multiple Enzymatic Cascade Reactions." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-230515.

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Engineering artificial cells is currently an emerging area of research that involves constructing mimics of biological cells. These biomimetic cellular systems hold tremendous promise for the different biomedical applications (diagnostics, therapy, tissue engineering, gene transfection, bioactive coatings) as well as aspects of synthetic biology. A key architectural principle of the cell is a multicompartmentalized assembly, which is one of the features of biological cells that enable the performance of multiple complex biochemical reactions within confined environments. For this purpose, this

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22

RYCHLET, ELLIOTT MARYSE. "Reactions de cyclisations radicalaires transannulaires en cascade : synthese totale de l'epi-illudol." Paris 6, 1998. http://www.theses.fr/1998PA066612.

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Le but recherche dans mon travail de these est la synthese totale de derives protoilludanes et triquinanes naturels connus pour leurs proprietes biologiques. La premiere partie du memoire (chapitre i) concerne l'etude bibliographique relative a ces composes ainsi que leur mode de biosynthese. La strategie definie pour acceder a ces differents sesquiterpenes est biomimetique et repose sur une cascade de cyclisations radicalaires transannulaires a partir d'un macrocycle a onze atomes de carbone. Dans ce but, une etude bibliographique dans le chapitre ii fait le point sur les reactions radicalair

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23

Richmond, Edward. "An asymmetric pericyclic cascade approach to oxindoles." Thesis, University of St Andrews, 2014. http://hdl.handle.net/10023/4459.

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The research in this thesis describes an asymmetric pericyclic cascade approach to the synthesis of a range of enantioenriched oxindoles using enantiopure oxazolidine derived nitrones and disubstituted ketenes. Chapter 1 aims to place this work in the context of the literature, describing other commonly employed or state-of-the-art asymmetric approaches to oxindoles and related compounds. Examples of where these approaches have been used successfully in the total synthesis of related indole alkaloids are also presented. The conception of this project within the group is also described alongsid

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24

Groome, Nigel Mark. "Invention of novel catalytic cascade reactions and their application to anticancer drug targets." Thesis, University of Leeds, 2011. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.612558.

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The main body of this thesis comprises four chapters: Chapter One serves as an introduction. The first two thirds deals with cell signalling cascades, focusing particularly upon protein kinases and the roles that their dysfunction play in cancerous processes and upon the methods employed to inhibit them in a bid to counter these processes. Kinase inhibition by small molecules is a very active area of research and notable clinical successes have been achieved. The last portion of the chapter addresses some of the issues surrounding .drug discovery, and ends by stating the author's intention to

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25

Lim, Yee Hwee. "Total sysntheses of bisanthraquinones through cascade reactions 18F-radiochemistry to advance cancer imaging." Thesis, University of Oxford, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.531975.

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26

Schmid, Ira [Verfasser]. "Bioinspired Catalytically Active Materials: ATPase Mimics and Artificial Enzymatic Cascade Reactions / Ira Schmid." Mainz : Universitätsbibliothek Mainz, 2019. http://d-nb.info/1189864215/34.

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27

Löwe, Jana [Verfasser]. "Enzymatic cascade reactions toward amino- and oxyfunctionalized fine and bulk chemicals / Jana Löwe." Bielefeld : Universitätsbibliothek Bielefeld, 2020. http://d-nb.info/1216625778/34.

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28

Babiker, Adil Abdelgadir. "Prostasome Modulation of Blood Cascade System and Phosphoprotein Reactions with Focus on Prostate Cancer." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis : Univ.-bibl. [distributör], 2005. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-5779.

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29

Gräfe, David, Jens Gaitzsch, Dietmar Appelhans, and Brigitte Voit. "Cross-linked polymersomes as nanoreactors for controlled and stabilized single and cascade enzymatic reactions." Royal Society of Chemistry, 2014. https://tud.qucosa.de/id/qucosa%3A36304.

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Polymeric vesicles or polymersomes are one of the supramolecular entities at the leading edge of synthetic biology. These small compartments have shown to be feasible candidates as nanoreactors, especially for enzymatic reactions. Once cross-linked and equipped with a pH sensitive material, the reaction can be switched off (pH 8) and on (pH 6) in accordance with the increased permeability of the polymersome membranes under acidic conditions. Thus cross-linked and pH sensitive polymersomes provide a basis for pH controlled enzymatic reactions where no integrated transmembrane protein is needed

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30

Hinzmann, Alessa [Verfasser]. "Chemoenzymatic cascade reactions towards aliphatic nitriles and amines starting from biorenewable resources / Alessa Hinzmann." Bielefeld : Universitätsbibliothek Bielefeld, 2020. http://d-nb.info/1221718983/34.

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31

Derasp, Joshua. "Development of Cascade Reactions and Strategies for Carbon Centred Nucleophilic Additions to Blocked Isocyanates." Thesis, Université d'Ottawa / University of Ottawa, 2019. http://hdl.handle.net/10393/39326.

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Isocyanates are invaluable bulk chemicals that play a central role in the synthesis of various polymers and provide a key platform for the synthesis of nitrogen-containing molecules such as carbamates and ureas. Unfortunately, isocyanates suffer from high toxicity, low functional group tolerance, and a propensity to undergo deleterious side-reactions. Consequently, blocked (masked) isocyanate derivatives have been the subject of increased interest resulting from their reduced toxicity and exceptional control over isocyanate reactivity. This strategy has largely been relegated to the polymeriza

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32

Tokimizu, Yusuke. "Synthesis of Heterocyclic Scaffolds through Transition-Metal-CatalyzedCascade Reactions of Alkynes." 京都大学 (Kyoto University), 2015. http://hdl.handle.net/2433/199500.

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33

Gao, Ming. "Ketone synthesis via rhodium-catalyzed traceless chelation-controlled hydroacylation reactions." Thesis, University of Oxford, 2018. http://ora.ox.ac.uk/objects/uuid:487b65f9-d1f7-4fee-b2bb-358837866ca2.

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This thesis documents the development of rhodium-catalyzed traceless chelation-controlled hydroacylation reactions for the synthesis of a variety of ketone products. <strong>Chapter 1</strong> provides an overview of rhodium-catalyzed hydroacylation chemistry, focusing on the origin of chelation-controlled strategies and the benefits thereof. <strong>Chapter 2</strong> describes a sequential reaction involving alkene hydroacylation, sulfide elimination and boronic acid conjugate addition, which affords products with the initial sulfide coordinating group replaced by a stereochemically defined

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34

Kivala, Milan. "Two-dimensional acetylenic scaffolding : extended donor-substituted perethynylated dehydroannulenes, charge-transfer chromophores, and cascade reactions /." Zürich : ETH, 2007. http://e-collection.ethbib.ethz.ch/show?type=diss&nr=17593.

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35

Müller, Christina Andrea [Verfasser]. "Multi-enzymatic cascade reactions for oxyfunctionalization of alkanes employing P450 BM3 monooxygenases / Christina Andrea Müller." Aachen : Hochschulbibliothek der Rheinisch-Westfälischen Technischen Hochschule Aachen, 2014. http://d-nb.info/1051427797/34.

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36

Ng, Sze-Sze. "Nickel-catalyzed coupling reactions and synthetic studies toward ent-dioxepandehydrothyrsiferol via an epoxide-opening cascade." Thesis, Massachusetts Institute of Technology, 2008. http://hdl.handle.net/1721.1/43730.

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Thesis (Ph. D.)--Massachusetts Institute of Technology, Dept. of Chemistry, 2008.<br>This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections.<br>Vita.<br>Includes bibliographical references.<br>Nickel-Catalyzed Coupling Reactions. Nickel-catalyzed allene--aldehyde coupling and alkene--aldehyde coupling represent two methods of preparing allylic alcohols. Most asymmetric transition metal-catalyzed methods of preparing enantiomerically enriched allylic alcohols rely on chiral ligands. The nickel-catalyzed a

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37

Levick, Matthew Thomas. "Connective-Pummerer cyclisations and SmI2-mediated cascade reactions for the synthesis of nitrogen-containing heteroacenes." Thesis, University of Manchester, 2013. https://www.research.manchester.ac.uk/portal/en/theses/connectivepummerer-cyclisations-and-smi2mediated-cascade-reactions-for-the-synthesis-of-nitrogencontaining-heteroacenes(762eea6e-0dc0-4397-8af0-07413517db63).html.

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This thesis describes work towards a range of novel nitrogen containing polyaromatic heterocycles for use as organic semiconductors. A route to benzo[b]carbazole end-capped oligothiophenes has been developed; relying on two key steps; namely a connective-Pummerer cyclisation and a SmI2-mediated cleavage–cyclisation cascade. A route to extended dibenzoindolo[3,2-b]carbazole-based aza-heptacenes has also been developed, by employing the same key steps in a two-directional manner. The physical and electronic properties of the resulting materials has been assessed, and the utility of the materials

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38

Conyers, Ryan C. "An Investigation of Gold(I) Catalyzed Cycloaddition Reactions." Miami University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=miami1366197923.

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39

Boudhar, Aicha. "Fenestranes, cyclooctatriènes et leurs dérivés comme châssis moléculaires innovants pour le développement de plateformes modulables." Phd thesis, Université de Strasbourg, 2012. http://tel.archives-ouvertes.fr/tel-00855441.

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Ces travaux de thèse nous ont permis de mettre en évidence un accès à un large nombre de composés polycycliques. Les étendues des méthodes employant des cascades réactionnelles palladocatalysées et leurs limites ont été étudiées. L'initialisation de ces cascades se fait par une cyclocarbopalladation de type de 4-exo-dig, suivie par un couplage de Sonogashira. Avec des substrats et des conditions adéquats, la cascade réactionnelle continue avec une alcynilation, une électrocyclisation à huit électrons p et une électrocyclisation à six électrons p. En un nombre limité d'étapes sont ainsi obtenus

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40

Anderson, Mattias. "Amine Transaminases in Multi-Step One-Pot Reactions." Doctoral thesis, KTH, Industriell bioteknologi, 2017. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-199646.

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Amine transaminases are enzymes that catalyze the mild and selective formation of primary amines, which are useful building blocks for biologically active compounds and natural products. In order to make the production of these kinds of compounds more efficient from both a practical and an environmental point of view, amine transaminases were incorporated into multi-step one-pot reactions. With this kind of methodology there is no need for isolation of intermediates, and thus unnecessary work-up steps can be omitted and formation of waste is prevented. Amine transaminases were successfully com

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41

Masdeu, Gámez Gerard. "Chloroperoxidase and D-fructose-6-phosphate aldolase in enzymatic cascade reactions for the synthesis of iminocyclitols." Doctoral thesis, Universitat Autònoma de Barcelona, 2017. http://hdl.handle.net/10803/457908.

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Aquest treball de tesi se centra en la viabilitat d’una reacció en cascada formada per una peroxidasa i una aldolasa per a la síntesi d’iminociclitols, que són inhibidors de glicosidases amb un enorme potencial terapèutic en moltes malalties, alterant la glicosilació o el catabolisme de glicoproteïnes. El sistema proposat consisteix en dos enzims –cloroperoxidasa (CPO) i D-fructosa-6-fosfat aldolasa (FSA)– per a la formació del precursor de D-fagomina, seleccionat com l’iminociclitol d’interès per a avaluar la viabilitat de l’acoblament d’ambdues reaccions. El substrat inicial és un β-amino al

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42

Kulig, Justyna [Verfasser], Martina [Akademischer Betreuer] Pohl, and Vlada [Akademischer Betreuer] Urlacher. "Stereoselective synthesis of vicinal diols with enzymatic cascade reactions / Justyna Kulig. Gutachter: Martina Pohl ; Vlada Urlacher." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2014. http://d-nb.info/1047666308/34.

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43

Murray, Lorna. "New gas-phase cascade reactions of stabilising phosphorus ylides leading to ring-fused indoles and quinolines." Thesis, University of St Andrews, 2010. http://hdl.handle.net/10023/971.

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Synthesis and flash vacuum pyrolysis (FVP) of stabilised phosphorus ylides containing an o-amino functionalised benzene ring has been examined for the first time. Model studies using N-methyl-N-tosyl and N-mesyl-N-methyl ylides showed that the ylides could be prepared, although yields were variable, and had the expected spectroscopic properties. Upon FVP, however, the expected loss of Ph₃PO and the sulfonyl group was accompanied by unexpected transfer of the reactive site from nitrogen to carbon giving 3- substituted quinolines rather than the expected indole products. Moving to ylides with an

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44

Blouin, Sarah. "Synthèse de cyclooctatétraènes par réactions en cascade palladocatalysées." Thesis, Strasbourg, 2016. http://www.theses.fr/2016STRAF048/document.

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Ces travaux de thèse ont permis de développer une voie d’accès à des systèmes polycycliques complexes contenant un cyclooctatétraène par réactions en cascade palladocatalysées à partir de substrats de départ originaux. Le mécanisme de formation de ces composés est tout à fait particulier. Une étude mécanistique approfondie, corroborée notamment par des calculs DFT, a mis en avant une étape de réaction inédite : une électrocyclisation conrotatoire 8pi d’un système triènyne formant ainsi un cyclooctadiènallène palladé. Cette méthodologie a permis de synthétiser de nombreux cyclooctatétraènes pré

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45

Mertens, Marie Anna Stephanie [Verfasser], Ulrich [Akademischer Betreuer] Schwaneberg, and Takashi [Akademischer Betreuer] Hayashi. "Combination of bio- and metal catalysts in chemoenzymatic cascade reactions / Marie Anna Stephanie Mertens ; Ulrich Schwaneberg, Takashi Hayashi." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1216040796/34.

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Mertens, Marie Anna Stephanie Verfasser], Ulrich [Akademischer Betreuer] [Schwaneberg, and Takashi [Akademischer Betreuer] Hayashi. "Combination of bio- and metal catalysts in chemoenzymatic cascade reactions / Marie Anna Stephanie Mertens ; Ulrich Schwaneberg, Takashi Hayashi." Aachen : Universitätsbibliothek der RWTH Aachen, 2019. http://d-nb.info/1216040796/34.

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Loiseau, Francis. "Cope-type Hydroamination of Alkenes with Hydroxylamines and Hydrazines - Scope and Mechanism." Thèse, Université d'Ottawa / University of Ottawa, 2013. http://hdl.handle.net/10393/23794.

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Hydroamination stands as a desirable approach to nitrogen-containing molecules, which have important applications ranging from pharmaceuticals (fine chemicals) to paints, coatings, insecticides and agrochemicals (bulk chemicals). It features the use of alkene and alkyne starting materials, which are abundant and rarely used in the formation of C-N bonds. This work aims at building on the improved Cope-type reactivity developed in the Beauchemin group by expanding the reach of the reaction and understanding its mechanistic complexities. The first part of this thesis describes the development of

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Salacz, Laura. "Synthèse de structures complexes par réactions en cascade et catalyse au rhodium." Thesis, Strasbourg, 2018. http://www.theses.fr/2018STRAF034/document.

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Ces travaux de thèse ont permis, au cours de deux projets, de s’attacher à la synthèse de structures complexes au moyen de réaction en cascade et de catalyse au rhodium.Dans une première partie, une méthodologie robuste pour la synthèse de 2,4,6-cycloheptatriénones entièrement substituées et non-symétriques par réaction de cycloaddition carbonylative [2+2+2+1] catalysée par des complexes de rhodium a été développée. Des mécanismes expliquant la formation des différents composés ont été proposés. Dans une seconde partie, l’application de l’hydroformylation désymétrisante catalysée au rhodium à

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Pantaine, Loïc. "Aminocatalyse et Réactions en Cascade pour la Synthèse de Polycycles Tridimensionnels." Thesis, Université Paris-Saclay (ComUE), 2016. http://www.theses.fr/2016SACLV084/document.

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Les travaux exposés dans ce manuscrit ont pour objectif d’étudier des séquences réactionnelles organocatalysées permettant la formation stéréosélective de liaisons carbone-carbone ou carbone-hétéroatome. Plusieurs stratégies ont été développées pour la préparation d’architectures cycliques chirales dont la synthèse représente un enjeu important en raison de leur présence dans un grand nombre de molécules d’intérêt biologique. Le manuscrit débute par une introduction sur le principe de l’organocatalyse en se focalisant sur les différents modes d’activation en aminocatalyse.Le premier chapitre t

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Maddirala, Amarendar Reddy. "Applications of Ugi Four Component Cascade Coupling Reactions for the Synthesis of Bioactive Diverse Heterocyclic Molecules and Natural Products." University of Toledo / OhioLINK, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=toledo1461775415.

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