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Journal articles on the topic 'Chloroacetyl chloride'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

D’Souza, Malcolm J., Zoon Ha Ryu, Byoung-Chun Park та Dennis N. Kevill. "Correlation of the rates of solvolysis of acetyl chloride and α-substituted derivatives". Canadian Journal of Chemistry 86, № 5 (2008): 359–67. http://dx.doi.org/10.1139/v08-028.

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Additional specific rates of solvolysis have been determined for acetyl chloride and diphenylacetyl chloride. These are combined with literature values to carry out correlation analyses, using the extended Grunwald–Winstein equation with incorporation of literature values for solvent nucleophilicity (NT) and solvent ionizing power (YCl). Parallel analysis are carried out using literature values for the specific rates of solvolysis of trimethylacetyl chloride, chloroacetyl chloride, phenylacetyl chloride, and α-methoxy-α-trifluoromethylphenylacetyl chloride (MTPAC). Chloroacetyl chloride and MT

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2

Zhao, Hong Chi, Juan Li Guo, Ai Juan Sun, and Ling Ling Gao. "Synthesis and Properties of Linear Chloroacetylated Polystyrene." Key Engineering Materials 428-429 (January 2010): 102–5. http://dx.doi.org/10.4028/www.scientific.net/kem.428-429.102.

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Polystyrene (PS) was synthesized by emulsion polymerization. The linear chloroacetylated PS was prepared high effectively by Friedel-Crafts acetylation of PS using chloroacetyl chloride and anhydrous aluminium chloride as chloroacetylation reagent and catalysts, respectively. The structure of chloroacetyl group is similar to that of chloromethyl group. In this method, carcinogenic compound (chloromethyl ether etc.) was avoided and the reactions of secondary cross link and multi-substitute could be eliminated. The resultant polymers were characterized by Fourier transform infrared spectrometery

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3

Journal, Baghdad Science. "Synthesis of Some new 2-(4-Aryliminophenoxy)N-Arylacetamide Via p-hydroxy benzaldehyde." Baghdad Science Journal 11, no. 2 (2014): 486–90. http://dx.doi.org/10.21123/bsj.11.2.486-490.

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Chloroacetamide derivatives (2a-g) have been prepared through reaction of chloroacetyl chloride(1) (which prepared by the reaction of chloroacetic acid with thionyl chloride) with primary aromatic amines and sulfa compounds to afford compounds (2a-g) which then reacted with p-hydroxy benzaldehyde via Williamson reaction to obtaine the new compounds 2-(4-formyl phenoxy)-N-aryl acetamide (3a-g). Finally , compounds (3a-g) will be use as a good synthon to prepare the Schiff bases represented by compounds 2-(4-aryliminophenoxy)-N-arylacetamide (4a-g). through , reaction with some primary aromatic

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4

Sakarya, Handan Can, and Aslı Ketrez. "Synthesis of Novel cis-2-Azetidinones from Imines and Chloroacetyl Chloride Using Triethylamine." Acta Chimica Slovenica 70, no. 4 (2023): 628–33. http://dx.doi.org/10.17344/acsi.2023.8451.

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A synthesis of a novel series of cis-2-azetidinones 2a–c was carried out by the cycloaddition reaction of imine 1a–c and chloroacetyl chloride in dry dichloromethane at 0–5 °C using triethylamine. The cycloaddition of the Schiff bases with chloroacetyl chloride resulted in the corresponding major product cis-2-azetidinone stereoisomers 2a–c. The synthesized compounds were characterized by analytical and spectral techniques (infrared, 1H NMR, 13C NMR, and elemental analysis).

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5

Tolba, Mahmoud S., Mostafa Sayed, Shaban A. A. Abdel-Raheem, Taher A. Gaber, Adel M. Kamal El-Dean, and Mostafa Ahmed. "Synthesis and spectral characterization of some new thiazolopyrimidine derivatives." Current Chemistry Letters 10, no. 4 (2021): 471–78. http://dx.doi.org/10.5267/j.ccl.2021.4.004.

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Thiazolopyrimidnes are considered one of the most interesting classes in heterocyclic chemistry due to their pharmaceutical importance. Herein, we report the synthesis of some new heterocyclic compounds containing thiazolopyrimidine starting from compound (1) which was previously prepared in literature. The starting compound was allowed to react with different alkylating agents such as chloroacetone, chloroacetyl chloride, and phenacyl bromide to afford derivatives (2-4). Compound (5), benzylidene derivative, was obtained by the reaction of compound (2) with benzaldehyde while amino-dicarbonit

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6

Goodall, Karen, та Andrew F. Parsons. "The Synthesis of α, β–Dehydroamino Acid Esters from Hydroxyamino Esters using Haloacetyl Halides". Journal of Chemical Research 2000, № 2 (2000): 54–55. http://dx.doi.org/10.3184/030823400103166508.

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The preparation of dehydroamino acid esters from reaction of β–hydroxy–α–amino esters with dichloroacetyl chloride, chloroacetyl chloride or trichloroacetyl chloride in the presence of base has been investigated.

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7

Al-muamin, Thanaa, Naeemah Al-lami, Suroor Rahman, and Rana Ali. "Synthesis, Characterization and Antimicrobial Activity of New Nucleoside Analogues from Benzotriazole." Chemistry & Chemical Technology 10, no. 3 (2016): 271–78. http://dx.doi.org/10.23939/chcht10.03.271.

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Novel derivatives of 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H- benzotriazole and 1-(´1, ´3, ´4, ´6-tetra benzoyl-β-D-fructofuranosyl)-1H-benzotriazole carrying Schiff bases moiety were synthesised and fully characterised. The protection of D-fructose using benzoyl chloride was synthesized, followed by nucleophilic addition/elimination between benzotriazole and chloroacetyl chloride to give 1-(1- chloroacetyl)-1H-benzotriazole. The next step was condensation reaction of protected fructose and 1-(1-chloroacetyl)-1H-benzotriazole producing a new nucleoside analogue. The novel nucle

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8

KRISHNA, C. JOSHI, N. PATHAK VIJAI, and K. GOYAL MAHENDRA. "Synthesis, Anticonvulsant and Analgesic Activities of some New Fluorine containing 1,3,5-Trisubstituted-hydantoins." Journal of Indian Chemical Society Vol. 62, Nov 1985 (1985): 904–8. https://doi.org/10.5281/zenodo.6325270.

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Department of Chemistry, University of Rajasthan Jaipur-302 004 Fifteen new fluorine containing Mannich bases derived from 1,5-disubstituted-arylhydantoins have been synthesised by treating the appropriate 1,5-disubstituted-arylhydantoins with secondary amine and formaldehyde in ethanol. Seven 1,5-disubstituted-arylhydantoins were treated with chloroacetyl chloride and the resulting 3chloroacetyl-derivatives converted into the corresponding 3-dialkylaminoacetyl-1,5- disubstituted-arylhydantoins on treatment with secondary amines. Representative compounds have been screened

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9

Furukawa, Mitsuru, Shigeru Kabashima, Yasuhiro Tomita, Tadashi Ohkawara, and Tetsuo Yamasaki. "Heterocyclizations of Thiosemicarbazones with a-Chloroacetyl Chloride." HETEROCYCLES 31, no. 12 (1990): 2139. http://dx.doi.org/10.3987/com-90-5541.

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10

Agirbag, Hikmet, Dogan Sümengen, Yaşar Dürüst, and Nedime Dürüst. "The Reaction of Amidoximes with Chloroacetyl Chloride." Synthetic Communications 22, no. 2 (1992): 209–17. http://dx.doi.org/10.1080/00397919208021295.

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11

Tverdokhlebov, Anton V., Andrey A. Tolmachev, and Yulian M. Volovenko. "Preparation of Diethyl 1-(Alkyl/Aryl-2-amino-4-oxo-4,5-dihydropyrrol-3-yl)phosphonates." Collection of Czechoslovak Chemical Communications 69, no. 2 (2004): 414–18. http://dx.doi.org/10.1135/cccc20040414.

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12

Lukina, Darya Yu, Maksim O. Drazhin, Victor V. Dotsenko, Nicolai A. Aksenov, and Inna V. Aksenova. "Synthesis of New Water-Soluble Bunte Salts Bearing Thieno[2,3-b]Pyridine-3-yl Substituents." Chemistry Proceedings 3, no. 1 (2020): 24. http://dx.doi.org/10.3390/ecsoc-24-08397.

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Upon treatment with chloroacetyl chloride, 3-aminothieno[2,3-b]pyridines gave the corresponding chloroacetamides. The latter readily react with sodium thiosulphate to afford water soluble S-alkylthiosulphates with pharmacophoric heterocyclic units.

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13

Raauf, Ayad M. R. "Synthesis, Characterization and Biological Activity of New Mefenamic acid - Oxoazetidine Derivatives." Al Mustansiriyah Journal of Pharmaceutical Sciences 13, no. 1 (2013): 75–81. http://dx.doi.org/10.32947/ajps.v13i1.181.

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Several new oxoazetidine derivatives based on mefenamic acid were synthesized via a four steps method in good yields.1st step was prepared 2-[2-chloro-N-(2,3- dimethylphenyl)acetamido]benzoic acid (2) by condensation of mefenamic acid with chloroacetyl chloride, which on amination with hydrazine hydrate in ethanol to give 2-[N- (2,3-dimethylphenyl)-2-hydrazinylacetamido] benzoic acid (3) in good yields(2nd step).Compound 3, on condensation with various aldehydes afforded a series of Schiff bases 2-[N- (2,3-dimethylphenyl)-2-(2-arylhydrazinyl)acetamido]benzoic acid (4a-f) (3rd step).A series of

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14

Flefel, Eman M., Walaa I. El-Sofany, Mahmoud El-Shahat, Arshi Naqvi, and Eman Assirey. "Synthesis, Molecular Docking and in Vitro Screening of Some Newly Synthesized Triazolopyridine, Pyridotriazine and Pyridine–Pyrazole Hybrid Derivatives." Molecules 23, no. 10 (2018): 2548. http://dx.doi.org/10.3390/molecules23102548.

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A series of novel pyridine and fused pyridine derivatives have been prepared starting from 6-(3,4-dimethylphenyl)-2-hydrazinyl-4-(thiophen-2-yl)-pyridine-3-carbonitrile 1 which on treatment with appropriate formic acid, acetic acid/ acetic anhydride, benzoyl chloride and/or carbon disulfide afforded the corresponding triazolopyridine derivatives 2–5. Also, treatment of hydrazide 1 with diethyloxalate, chloroacetyl chloride, chloroacetic acid and/or 1,2-dichloroethane yielded the corresponding pyridotriazine derivatives 7–10. Further transformation of compound 1 with a different active methylen

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15

Zhu, Fuxing, Liang Li, Dafu Zhang, Shangrun Ma, Zhanshan Ma, and Kehui Qiu. "Separation and Rectification of Chloroacetyl Chloride from TiCl4." Processes 9, no. 2 (2021): 287. http://dx.doi.org/10.3390/pr9020287.

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Titanium tetrachloride (TiCl4) is an important intermediate material for the preparation of titanium products. The organic impurities in TiCl4 are easily accumulated during the production of titanium sponges due to the problems of imperfect detection methods and the lack of effective control methods, resulting in a poor quality of sponge titanium. Among all impurities, chloroacetyl chloride (CAC) is the most important in TiCl4. Herein, the determination of the CAC content in TiCl4 solution, with a low detection limit of 0.633 ppm, was established by the standard addition method using Fourier t

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16

Feshin, V. P., and G. B. Soifer. "Structure and rotational isomerism of chloroacetyl chloride molecules." Russian Journal of General Chemistry 76, no. 3 (2006): 356–58. http://dx.doi.org/10.1134/s1070363206030042.

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17

Nirmal, Bharat and Koppula Poonam. "Synthesis of Tri-chloroacetyl Chloride using Green and Sustainable Manufacturing Process." Interwoven: An Interdisciplinary Journal of Navrachana University 6, no. 1 (2023): 67–73. https://doi.org/10.5281/zenodo.8220236.

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18

Neelgundmath, Mahabaleshwaraiah, and Oblennavar Kotresh. "Synthesis, Evaluation and Characterization of Some 1,3,4-Triazole-2-one Derivatives as Antimicrobial Agents." E-Journal of Chemistry 9, no. 4 (2012): 2407–14. http://dx.doi.org/10.1155/2012/672125.

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A series of novel compounds like 3[(phenyl substituted)-5-methyl-1(Benzosulphonylamine)]-1,3,4-triazole-2-ones II(a-f) were synthesized by treating 4-amino-1-phenyl-3-methyl-5-oxo-1,2,4-triazoles with benzene sulphonyl chloride using pyridine as solvent. Similarly by using 4-amino-1-aryl-3-methyl-5-oxo-1,2,4-triazoles and acetic anhydride as starting material 3[(phenyl substituted)-5-methyl-1(acetylamino)]-1,3,4-triazole-2-ones III(a-f) were synthesized and also 3[(phenyl substituted)-5-methyl-1(chloroacetyl)]-1,3,4-triazole-2-ones I(a-f) were synthesized by treating 4-amino-1-aryl-3-methyl-5-

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19

Zaki, Remon M., Adel M. Kamal El Dean, Maisa I. Abd El Monem, and Mohamed A. Seddik. "Novel synthesis and reactions of pyrazolyl-substituted tetrahydrothieno[2,3-c]isoquinoline derivatives." Heterocyclic Communications 22, no. 2 (2016): 103–9. http://dx.doi.org/10.1515/hc-2015-0204.

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AbstractTreatment of isoquinolinecarboxamide 4a with triethyl orthoformate, chloroacetyl chloride or carbon disulfide afforded the pyrimidinone 7, oxopyrimidinethione 12 and chloromethylpyrimidinone 18, respectively. These products were used as versatile starting materials for synthesis of other heterocyclic compounds. The heterocyclic hydrazide 6 was also obtained.

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20

AL-ALAAF, Hiba Ameen, and Mohammed A. AL-IRAQI. "Synthesis of Some New Hydrazones from Quinazolinone Moiety." Eurasia Proceedings of Science Technology Engineering and Mathematics 16 (December 31, 2021): 52–56. http://dx.doi.org/10.55549/epstem.1068546.

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Methyl α-[(4-oxoquinazolin-2-yl)thio]acetate (4) is one of the important heterocyclic compounds. It isused as a precursor to synthesis new derivatives of quinazolin-4-one moiety. The compound (4) was synthesized via a series of steps from anthranilic acid. The anthranilic acid was converted to its methyl ester (1) by esterification with methanol under acidic condition. The ester (1) was reacted with chloroacetyl chloride to produce methyl α-chloroacetamido benzoate (2). The chloro compound (2) was converted to the corresponding thiocyanato compound (3) by its reaction with ammonium thiocyanate

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21

Li, Ya, Huiqing Yang, Linyu Jin, Wen-Peng Wu, and Dagang Yang. "Theoretical study on the mechanism of chloroacetyl chloride decomposition." Computational and Theoretical Chemistry 1086 (June 2016): 52–57. http://dx.doi.org/10.1016/j.comptc.2016.04.021.

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22

KABASHIMA, S., Y. TOMITA, T. OHKAWARA, T. YAMASAKI та M. FURUKAWA. "ChemInform Abstract: Heterocyclizations of Thiosemicarbazones with α-Chloroacetyl Chloride." ChemInform 22, № 45 (2010): no. http://dx.doi.org/10.1002/chin.199145164.

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23

AGIRBAS, H., D. SUEMENGEN, Y. DUERUEST, and N. DUERUEST. "ChemInform Abstract: The Reaction of Amidoximes with Chloroacetyl Chloride." ChemInform 23, no. 24 (2010): no. http://dx.doi.org/10.1002/chin.199224069.

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24

Patel, H. S., H. D. Desai, and H. J. Mistry. "Synthesis and Antimicrobial Activity of Some New Piperazine Derivaties Containing Aryl Sulfonyloxy Group." E-Journal of Chemistry 1, no. 2 (2004): 93–98. http://dx.doi.org/10.1155/2004/732420.

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NovelN-substituted piperazine derivatives containing sulfonyloxy aniline moiety have been prepared. The various 4-sulfonyloxy aniline (SA) derivatives (2a-h) have been prepared by the condensation reaction ofN-Acetyl Sulfanilyl chloride (ASC) and sodium phenates followed by hydrolysis. The SA derivatives are then reacted with chloro acetyl chloride to give corresponding (N-Chloroacetyl) derivatives (3a-h). These derivatives are then reacted withN-phenyl piperazine to yield the corresponding piperazine derivatives (4a-h).

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25

Dotsenko, Victor V., Karina V. Khalatyan, Alena A. Russkih, and Aminat M. Semenova. "New Quinoxaline-1,4-Dioxides Derived from Beirut Reaction of Benzofuroxane with Active Methylene Nitriles." Chemistry Proceedings 3, no. 1 (2020): 14. http://dx.doi.org/10.3390/ecsoc-24-08391.

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Benzofuroxane reacts under Beirut reaction conditions with active methylene nitriles to give new 2-aminoquinoxaline-1,4-dioxides. The treatment of known 2-amino-3-cyanoquinoxaline-1,4-dioxide with chloroacetyl chloride afforded corresponding chloroacetamide which is useful for the preparation of various heterocycles bearing a quinoxaline-1,4-dioxide core system.

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26

Ongania, Karl-Hans. "Synthesis of 3,4-Benzo-1-oxacephem / Synthesis of 3,4-Benzo-1-oxacephem." Zeitschrift für Naturforschung B 40, no. 1 (1985): 115–19. http://dx.doi.org/10.1515/znb-1985-0121.

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The thioformimidate 4, which may be obtained by S-methylation of 5 reacts with chloroacetyl chloride/triethylamine to yield the trans-2-azetidinone 7. 7 is dehalogenated to 8. Removal of the protective group leads to 9, which undergoes ring closure by the action with mercuric chloride/ mercuric oxide. Chlorolysis of 8 and the subsequent reaction with hydrofluoric acid/acetonitrile yields 12. The treatment of 12 with silver tetrafluoroborate/silver oxide gives also the title compound 10

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27

El-Bindary, Ashraf A., Peter Klaeboe, Claus J. Nielsen, et al. "The Conformational Equilibria and Vibrational Spectra, Including Infrared Matrix Isolation Spectra, of Chloroacetyl Chloride and Chloroacetyl Bromide." Acta Chemica Scandinavica 45 (1991): 877–86. http://dx.doi.org/10.3891/acta.chem.scand.45-0877.

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28

Mahyavanshi, Vinay, and Sunil I. Marjadi. "Design and Synthesis of 1-(2-amino-1-(4-methoxyphenyl)ethyl) cyclohexanol Analogs as Potential Microbial Agents." International Journal of Drug Design and Discovery 2, no. 2 (2024): 474–82. https://doi.org/10.37285/ijddd.2.2.6.

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1-(2-amino-1-(4-methoxyphenyl)ethyl)cyclohexanol (1), on condensation with chloroacetyl chloride yielded 2-chloro-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamide (2), which on amination with hydrazine hydrate yielded in turn 2-hydrazinyl-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamide (3). Compound 3, on condensation with various aromatic aldehydes afforded a series of 2-(2-benzylidenehydrazinyl)-N-(2-(1-hydroxycyclohexyl)-2-(4-methoxyphenyl)ethyl)acetamides 4a-n, which upon dehydrative annulation in the presence of chloroacetyl chloride and triethylamine yielded 2-

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29

S., Guru, Yadav R., Srivastava Soumya, K. Srivastava S., and D. Srivastava S. "Synthesis of some new N1-[(2-oxo-3-chloro-4-aryl-azitidin)-(acetyl amino)]-indole derivatives and their pharmacological activity." Journal of Indian Chemical Society Vol. 83, Dec 2006 (2006): 1236–124. https://doi.org/10.5281/zenodo.5834026.

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Synthetic Organic Chemistry Laboratory, Department of Chemistry, Dr. H. S. Gour University, Sagar-470 003, Madhya Pradesh, India <em>E-mail </em>: professorsks@rediffmail.com <em>Manuscript received 17 March 2006, revised 25 July 2006, accepted 7 September 2006</em> Indole on reaction with chloroacetyl chloride afforded N<sup>1</sup>-(1-chloro acetyl)-indole which was renuxed with hydrazine hydrate to give <em>N</em><sup>1</sup>-[(1-hydrazino)acetyl]-indole. The hydrazino derivative of indole was further treated with various substituted aromatic carbonyls to get <em>N</em><sup>1</sup>-[(benzyl

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30

Sheikhi, Ehsan, Mehdi Adib, Rozita Yazzaf, Mehdi Jahani, and Mehdi Ghavidel. "A Domino Process for the Sustainable Synthesis of Quinazolin-4(3H)-ones with Direct Chemo- and Regioselective Bromination." Synlett 29, no. 15 (2018): 2046–50. http://dx.doi.org/10.1055/s-0037-1610226.

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An efficient approach is reported for the direct and sustainable construction of quinazolin-4(3H)-ones through a three-component reaction of isatoic anhydride, primary amines, and bromoacetyl bromide or chloroacetyl chloride in the presence of K2CO3 in DMSO. With bromoacetyl bromide, mono- or dibrominated quinazolinone scaffolds were obtainable in a chemo- and regioselective manner.

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31

Chikava, Alexandra R., Alexei A. Dolganov, and Victor V. Dotsenko. "On the Acylation of 1,6-Diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles." Chemistry Proceedings 3, no. 1 (2020): 34. http://dx.doi.org/10.3390/ecsoc-24-08315.

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Here, 1,6-diamino-2-oxo-1,2-dihydropyridine-3,5-dicarbonitriles, prepared by the reaction of cyanoacethydrazide with arylmethylene malononitriles, react with 1-cyanoacetyl-3,5-dimethylpyrazole and chloroacetyl chloride to give corresponding cyanoacetamides and chloroacetamides. The reaction with phthalic anhydride proceeds under harsh conditions to give 4,7-dioxo-4,7-dihydropyrido[1′,2′:2,3][1,2,4]triazolo[5,1-a]isoindole- 1,3-dicarbonitriles.

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32

Dotsenko, Victor V., Aminat M. Semenova, and Nicolai A. Aksenov. "New Reactions of 5-Amino-3-(Cyanomethyl)-1H-Pyrazole-4-Carbonitrile." Chemistry Proceedings 3, no. 1 (2020): 23. http://dx.doi.org/10.3390/ecsoc-24-08398.

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5-Amino-3-(cyanomethyl)-1H-pyrazole-4-carbonitrile, prepared by reaction of malononitrile dimer with hydrazine, smoothly reacts with chloroacetyl chloride to form 2-chloro-N-(4-cyano-3-(cyanomethyl)-1H-pyrazol-5-yl)acetamide in good yield. The latter easily reacts with 3-cyanopyridine-2-thiolates to give hybrid molecules bearing nicotinonitrile and pyrazole units.

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33

Hussain, Sayyed, Shivaji Jadhav, Megha Rai, and Mazahar Farooqui. "Synthesis, Characterization and Biological Evaluation of N [3-Chloro-2 (aryl)-4-oxoazitidin-1-y] pyridine-4-carboxamide." International Journal of Drug Design and Discovery 2, no. 3 (2024): 527–32. https://doi.org/10.37285/ijddd.2.3.3.

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Isoniazid on addition with different aromatic aldehyde gives Schiff’s bases. The Schiff base so formed on treatment with chloroacetyl chloride and triethyl amine as a base catalyst in 1-4 Dioxan gives product 2a-2n.The synthesized compounds characterized by spectral analysis like IR, NMR & Mass and elemental analysis. The compounds were screened by anticonvulsant and antimycobacterial activity.

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34

Baraa H. Latief and Ahmed A. H. Ahmed. "Addition reactions to Schiff,s bases and preparation of new thioureas compounds." Tikrit Journal of Pure Science 21, no. 4 (2023): 73–78. http://dx.doi.org/10.25130/tjps.v21i4.1055.

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During this research a number of thiourease compound by the reaction of some prepared amides (from the reaction of Schiffs, bases with acetyl , chloroacetyl and benzoyl chloride ) with thiourea in the presence of sodium carbonate , the prepared compounds have been characterized by I.R spectroscopy and some of them by 1H-NMR and 13C-NMR and micro analysis (C.H.N.S).

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35

Sokhraneva, V. A., D. A. Yusupova, V. S. Boriskin, and N. V. Groza. "Obtaining substituted phenol derivatives with potential antimicrobial activity." Fine Chemical Technologies 17, no. 3 (2022): 210–30. http://dx.doi.org/10.32362/2410-6593-2022-17-3-210-230.

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Objectives. With the growing resistance of pathogenic microorganisms to antibiotics, the development of new antimicrobial drugs offering specific mechanisms of action becomes an urgent task. Only few antimicrobials offer a broad spectrum of activity against gram-positive and gram-negative bacteria, molds, and yeasts. In this regard, the purpose of the work was to develop methods for synthesizing biologically active derivatives of alkyl-substituted phenols (reactions at the hydroxy group) to study their biological effect.Methods. The synthesis of imidazole acetates of substituted phenols was ca

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36

Ağibaş, Hikmet, Ayşle Gül Kaya, and Murat Aydoğdu. "REACTION OF SUBSTITUTED BENZAMIDE OXIMES WITH CHLOROACETYL CHLORIDE AND THIOPHOSGENE." Phosphorus, Sulfur, and Silicon and the Related Elements 149, no. 1 (1999): 39–48. http://dx.doi.org/10.1080/10426509908037021.

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37

Veerabhadraiah, Udarapu, Vedeela Rajeswar Rao, and Tadepalcy Venkata Padmanabha Rao. "Reaction of mercaptoacetic acid and chloroacetyl chloride with benzalamino thiazolyl coumarins." Collection of Czechoslovak Chemical Communications 55, no. 2 (1990): 535–39. http://dx.doi.org/10.1135/cccc19900535.

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2-Aryl-3-[4-(2-oxo-2H-1-benzopyran-3-yl)-2-thiazolyl]-4-thiazolidinones (III), have been synthesized by the reaction of Schiff's bases (II) derived from 3-(2-amino-4-thiazolyl)-2H-1-benzopyran-2-ones (I) with mercaptoacetic acid. The Schiff's bases on reaction with chloroacetyl chloride in the presence of triethylamine in dioxane gave chloroacetamido derivative (IV) instead of expected compound V.

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38

Ogurtsova, D. N., I. V. Palamarchuk, and I. Kulakov. "Synthesis of monothiooxamide derivatives based on chloroacetamides of 3-aminopyridin-2(1n)-ones." BULLETIN of the L.N. Gumilyov Eurasian National University. Chemistry. Geography. Ecology Series 139, no. 2 (2022): 28–32. http://dx.doi.org/10.32523/2616-6771-2022-139-2-28-32.

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On the basis of biologically active 3-aminopyridine-2(1H)-ones, the authors carried out chemical modification into derivatives of the corresponding monothiooxamides for the first time. It has been shown that monothiooxamides of 3-aminopyridin-2(1H)-oneenter into transamidation reactions with hydrazine-hydrate and are further cyclized under the action of chloroacetyl chloride into conjugated 1,3,4-thiadizole derivatives.

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39

M., B. HOGALE, K. SALUNKHE V., and S. KACHARE D. "Preparation of 5-Methyl-N-propylamino- 2,3-dihydroindole Derivatives." Journal of Indian Chemical Society Vol. 66, Jul 1989 (1989): 484–86. https://doi.org/10.5281/zenodo.6223842.

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Department of Chemistry, Shivaji University, Kolhapur-416 004 <em>Manuscript received 8 April 1987, revised 26 July 1988,accepted 23 May 1989</em> Preparation of 5-Methyl-<em>N</em>-propylamino-  2,3-dihydroindole Derivatives

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40

AL-Tamimi, Entesar Obeed, Raad Mahjoub Muslih, and Khalida Ali Thejeel. "Synthesis, Characterization and Antibacterial Studies of 2-azetidinones Compounds Derived from Amoxicillin." Al Mustansiriyah Journal of Pharmaceutical Sciences 15, no. 1 (2015): 14–23. http://dx.doi.org/10.32947/ajps.v15i1.160.

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In this study, the new azetidinones were synthesized from Schiff bases 2(a-j) that derived from amoxicillin (1) on treatment with chloroacetyl chloride in presence of triethylamine gave azetidinone 3(a-j). The structure of these compounds have been elucidated on the basis of their physical and spectral. Azetidinone compounds were also screened for their antibacterial activity against some bacterial species using amoxicillin as standard.

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41

Pulate, Chetan P., Gurubasavrajswamy P. M., Rishikesh V. Antre, and Divakar Goli. "Microwave-Assisted Synthesis and Antimicrobial Activity of Novel Azetidinones from Dehydroacetic Acid." International Journal of Drug Design and Discovery 2, no. 2 (2024): 483–87. https://doi.org/10.37285/ijddd.2.2.7.

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This paper describes the reaction of dehydroacetic acid with primary aromatic amines to yield Schiff bases (2a-2g) by using microwave system. Schiff bases irradiated with dimethyl formamide in presence of triethyl amine and chloroacetyl chloride to afford azetidinones (3a-3g) in excellent yields. The products, characterized on the basis of spectral data, have shown moderate to good antimicrobial activity against some bacteria and fungi.

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42

Siddiqui, Abdul U., Yelluru Satyanarayana та Abdul H. Siddiqui. "Synthesis of trans β-Lactams of Estrane Series". Collection of Czechoslovak Chemical Communications 60, № 7 (1995): 1186–90. http://dx.doi.org/10.1135/cccc19951186.

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17,17-Ethylenedioxy-1,3,5(10)-estratrien-3β-ol (I) was converted into ethyl ester II by reaction with ethyl chloroacetate in the presence of potassium. The ethyl ester II on reaction with hydrazine gave hydrazide III, which on condensation with aromatic aldehydes gave Schiff bases IVa-IVd. The reaction of Schiff bases IVa-IVd with chloroacetyl chloride in the presence of triethylamine afforded β-lactams Va-Vd.

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43

Müller, Harald, Heinz P. Fritz, Ralf Nemetschek, Rudolf Hackl, Werner Biberacher та Claus-Peter Heidmann. "Synthesis and Properties of Bis-(phenylenedithio)-tetrathiafulvalene (BPhDT-TTF): a New π-Donor for Organic Metals". Zeitschrift für Naturforschung B 47, № 5 (1992): 718–24. http://dx.doi.org/10.1515/znb-1992-0519.

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The new π-donor bis-(phenylenedithio)-tetrathiafulvalene (5), synthesized via phosphite coupling of 2-oxo-1,3-dithiolo-[4,5b][1,4]-benzodithiin (4), has been prepared in 5 steps starting from 1,2-dimercaptobenzene and chloroacetyl chloride. Spectroscopic and electrochemical data point to a close similarity of 5 and dibenzo-tetrathiafulvalene (DB-TTF). 5 forms a highly conducting radical-cation salt (σRT = 100 S/cm) with AsF6- as counter ion.

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44

Y., D. KULKARNI, SRIVASTAVA D., BISHNOI ABHA та R. DUA P. "Synthesis of 3-[ α-(3-Chloro-2-oxo-4-substituted-phenyl/ furfuryl-1-azetidinyl)]-2H-1-benzopyran-2-ones and 3-[α-(2-Substituted-phenyl/furfurylthiazolidiznyI)]-2H -1- benzopyran-2-ones as C.N.S. -active Agents". Journal of Indian Chemical Society Vol. 73, Apr-May 1996 (1996): 173–75. https://doi.org/10.5281/zenodo.5891876.

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Department of Chemistry, Lucknow University, Lucknow-226 007 Pharmacology Division, Central Drug Research Institute, Lucknow-226 007 Manuscript received 31 January 1994, revised 26 July 1994, accepted 21 September 1994 Reaction of 3-substituted-phenylidine/furfurylidineamino-2<em>H</em>-1-benzopyran-2-ones (3a-d) with chloroacetyl chloride and thioglycolic acid affords the corresponding four-membered azetidinones (4a-d) and five-membered thiazolidinones (5a-d) respectively. All the compounds were tested for their acute toxicity, effects on gross behaviour, spontaneous motor activity (SMA), ano

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45

Bentley, T. William, H. Carl Harris, Zoon Ha Ryu, Gui Taek Lim, Dae Dong Sung, and Stanley R. Szajda. "Mechanisms of Solvolyses of Acid Chlorides and Chloroformates. Chloroacetyl and Phenylacetyl Chloride as Similarity Models." Journal of Organic Chemistry 70, no. 22 (2005): 8963–70. http://dx.doi.org/10.1021/jo0514366.

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46

Hacaloglu, Jale, Ali Gokmen, and Sefik Suzer. "Negative ion formation in chloroacetyl chloride, trichloroacetyl chloride, and chloroacetaldehyde under low-energy electron impact." Journal of Physical Chemistry 94, no. 11 (1990): 4412–15. http://dx.doi.org/10.1021/j100374a011.

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47

S. Hmood, Kasim, and Amer N. Elias. "Synthesis, Characterization, and Antimicrobial Evaluation of New Ceftriaxone Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN 1683 - 3597 E-ISSN 2521 - 3512) 23, no. 2 (2017): 75–88. http://dx.doi.org/10.31351/vol23iss2pp75-88.

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The present study was designed to synthesize a number of new Ceftriaxone derivatives by its involvement with a series of different amines, through the chemical derivatization of its 2-aminothiazolyl- group into an amide with chloroacetyl chloride, which on further conjugation with these selected amines will produce compounds with pharmacological effects that may extend the antimicrobial activity of the parent compound depending on the nature of these moieties. Ceftriaxone was first equipped with a spacer arm (linker) by the action of chloroacetyl chloride in aqueous medium and then furth

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48

Patel, N. Z., J. N. Patel, and R. M. Patel. "Synthesis and Biological Activity of Polyketone Resins-IV. Systems Based on m-Xylene with Nitrobenzene as Solvent." High Performance Polymers 4, no. 3 (1992): 141–49. http://dx.doi.org/10.1088/0954-0083/4/3/002.

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Seven chlorine-terminated polyketones of low molecular weight were prepared from m-xylene, chloroacetyl chloride and ao-dichloroalkanes, i.e. dichloro-methane and 1,2-dichloroethane, by the Friedel-Crafts reaction using nitrobenzene as solvent. The polyketones were characterized by [R spectra and vapour pressure osmome-t'y. The thermal properties were studied by thermogravimetry and differential scanning calorimetry. The kinetic parameters for the decomposition reactions were evaluated by the Broido and Doyle methods. The polyketones were found to be thermally sable up to 220°C but decompose b

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49

Klein, Andrew J., Susan G. Morrell, Orville H. Hicks, and Jimmy W. Worley. "Determination of chloroacetyl chloride in air by high-performance liquid chromatography." Analytical Chemistry 58, no. 4 (1986): 753–55. http://dx.doi.org/10.1021/ac00295a022.

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50

Khalid M, Rawha'a, Ayad Suliman H, and Fahdel Dawood Kh. "Design, Synthesis and Investigation of Mefenamic Acid Containing Thiazolidine-4-one." Journal for Research in Applied Sciences and Biotechnology 2, no. 5 (2023): 146–60. http://dx.doi.org/10.55544/jrasb.2.5.24.

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Mefenamic acid and chloroacetyl chloride were mixed together to make 2-(2-chloro-N-(2,3-dimethylphenyl) acetamido) benzoic acid. The last compound prepared reacted with hydrazine hydrate to get 2-(N-(2,3-dimethylphenyl)-2-hydrazineylacetamido) benzoic acid, Condensed substituted benzaldehydes were utilized to make Schiff bases; Through cyclization reactions with thioglycolic acid, these compounds were transformed into 2,3-disubstituted thiazolidine-4-one; and finally, all structures were described using FT-IR, 1H-NMR, and mass spectrometry.

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