To see the other types of publications on this topic, follow the link: Colidae.
Dissertations / Theses on the topic 'Colidae'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Colidae.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Morteau, Olivier. "Altérations de la motricité colique et de la sensibilité viscérale dans la colite expérimentale chez le rat. Approches pharmacologiques." Toulouse 3, 1994. http://www.theses.fr/1994TOU30028.
Full textAbstract:
Les colites chez l'homme se traduisent par des lesions organiques et des anomalies fonctionnelles incluant une alteration de la motricite colique et une exacerbation de la sensibilite viscerale. Notre objectif etait d'adapter des modeles animaux reproduisant ces troubles fonctionnels, afin d'en etudier les mediateurs biochimiques. L'etude basee sur la mesure par electromyographie de la motricite colique in vivo chez le rat, decrit les troubles de la motricite du colon proximal en reponse a une inflammation par l'acide trinitrobenzene sulfonique (tnb). L'utilisation d'inhibiteurs de la synthese et d'antagonistes des recepteurs des principaux mediateurs de la colite montre l'implication du platelet-activating factor (paf) et de l'interleukine-1 (il-1) dans ces alterations. Nous definissons ensuite un modele de douleur viscerale base sur la distension rectale, induisant d'une part une inhibition amont de la motricite colique, d'autre part une augmentation des contractions des muscles de l'abdomen. L'inflammation rectale par le tnb genere une hypersensibilite caracterisee par un abaissement du seuil d'apparition des deux reponses a la distension. L'administration peripherique d'antagonistes des recepteurs 5-ht3 de la 5-hydroxytryptamine (5-ht) revele que les recepteurs 5-ht3 participent a la fois aux alterations motrices induites par la distension et a l'hypersensibilite viscerale generee par le tnb. L'injection intraperitoneale du precurseur de la 5-ht induit une augmentation de la reponse abdominale douloureuse a la distension rectale, permettant l'etude du role des autres recepteurs de la 5-ht (5-ht1, 5-ht2, 5-ht4) dans l'hypersensibilite viscerale. En conclusion, les troubles moteurs associees a la colite experimentale chez le rat impliquent certains des mediateurs (paf, il-1) responsables des lesions organiques. Toutefois, d'autres mediateurs n'intervenant pas directement dans la colite, comme la 5-ht, participent a l'hypersensibilite viscerale induite par une rectocolite, via les recepteurs 5-ht3 dans le cas de la 5-ht
2
DELONGA, OLIVIER. "Interet de l'electromyographie colique dans la constipation par inertie colique." Clermont-Ferrand 1, 1993. http://www.theses.fr/1993CLF1MS09.
Full text
3
Calleja, Medel Gilda Virginia. "Antonio Colinas, traductor /." León : Univ. de León, Secr. de Publ. y Medios Audiovisuales, 2003. http://www.gbv.de/dms/sub-hamburg/487873084.pdf.
Full text
4
Di, Martino Françoise. "Appendicite et cancer colique." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M205.
Full text
5
Santos, Renato Daniel Freitas dos. "Residir na colina." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2020. http://hdl.handle.net/10400.5/20386.
Full textAbstract:
Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Arquitetura apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.<br>A crise climática, a crise da habitação e o crescimento populacional mundial surgem como os
principais desafios do século XXI. A resposta para estes três temas pode ser encontrada na
transformação das nossas cidades. A procura pelo desenvolvimento sustentável do território
urbano e do modo de construção constitui este presente trabalho.
Por ser uma região com grande potencial de desenvolvimento ecológico, social e económico,
o Vale de Alcântara, situado na cidade de Lisboa, torna-se um local ideal para a intervenção
desta investigação.
Ao longo da história, este lugar, tem sido vítima de grandes alterações na sua fisionomia em
deterioramento do ecossistema tronando-o cada vez mais difícil de habitar. Serão então apresentadas
as principais metodologias e princípio teóricos que justificam a recuperação deste
lugar.
O documento resulta da recolha de dados interdisciplinares do âmbito científico, histórico,
urbanístico e arquitetónico.<br>ABSTRACT: The climate crisis, the housing crisis and world population growth appear as the main
challenges of the 21st century. The answer to these three themes can be found in the
transformation of our cities. The search for the sustainable development of the urban territory and
the construction mode constitutes this present work.
Being a region with great potential for ecological, social and economic development, the
Alcântara Valley, located in the city of Lisbon, becomes an ideal place for the intervention of this
research.
Throughout history, this place has been the victim of major changes in its deteriorating
ecosystem physiognomy making it increasingly difficult to inhabit. The main theoretical
methodologies and principles that justify the recovery of this place will be here presented.
The document results from the collection of interdisciplinary data from the scientific, historical,
urban and architectural fields.<br>N/A
6
Eskinazi, Rally. "Contribution à la carcinogénèse colique." Doctoral thesis, Universite Libre de Bruxelles, 2000. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211700.
Full text
7
Ahmed, Proteek. "Uma ilha na colina." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2019. http://hdl.handle.net/10400.5/18192.
Full textAbstract:
Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Interiores e Reabilitação do Edificado apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.<br>O Trabalho que aqui se apresenta focaliza-se no fenómeno das Ilhas na cidade do Porto. Este tipo de edificado faz parte do passado e do presente deste território, tendo ainda uma presença significativa e emblemática na malha urbana da cidade. Na sua origem, foram soluções habitacionais proporcionadas aos operários que afluíram à cidade do Porto à procura de trabalho nas indústrias tradicionais, mas florescentes da cidade, sobretudo a partir de meados do século XIX. Tal como no passado, também na atualidade estamos perante espaços invisíveis na cidade, que passam desapercebido aos cidadãos e visitantes, uma vez que a sua edificação ocorreu no interior dos quarteirões da urbe. Contudo, aqui, encontramos uma cidade-aldeia, dotada de uma vida social marcada por fortes relações de interconhecimento e de interajuda entre os vizinhos, pela existência de uma certa densidade relacional, mesmo no modo como as pessoas se apropriam dos espaços coletivos circundantes.
De forma mais específica, o nosso olhar recaiu sobre as ilhas do bairro das Fontaínhas, constituindo o local de estudo e de intervenção em termos urbanos e arquitetónicos. Este bairro é composto por três ilhas que foram edificadas junto à fábrica de cerâmica que aí existia: a Ilha da Tapada, a Ilha da Maria Vitorina e a Ilha Olímpia. Estas três ilhas pousam em socalcos sobre a colina íngreme das Fontaínhas, encontrando-se num estado devoluto acentuado. As habitações de tipologia “ilha” que aí ainda resiste, apresentam graves problemas de salubridade e precárias condições de habitabilidade.
Este Projeto Final de Mestrado desenvolve algumas soluções capazes de regenerar e revitalizar este espaço degradado e esquecido da cidade. Acredita-se que é possível qualificar este espaço urbano, de modo a dar continuidade e coerência urbana a esta zona ribeirinha; para além disso, procura-se reabilitar as construções precárias que aí existem, de forma e por um lado, devolver as habitações aos seus moradores, e por outro, proporcionar condições dignas de alojamento a renda acessível, atenuando-se assim a falta de habitação nestes espaços que fazem parte da paisagem (social) da cidade do Porto.<br>ABSTRACT: The present document highlights a phenomenon know as Ilhas do Porto in the city of OPorto. This sets of mass with significant presence in the urban mesh of the city are a result of the constructions built during the industrial development of the city. Known as working quarters where people were housed at, this masses started to invade Oporto’s city on a greater scale from the 19th century forward/onward, in order to improve living conditions for those who were looking to work at the industries. Nowadays, this working quarters are invisible spaces within the city that go unnoticed to any passersby due to its implementation inside the city blocks. However, people who still live in this spaces revealed strong community ties and also a strong feeling of neighborhood through the help and feelings shared between them and wihtin the space. Therefor, this strong feeling of neighborhood and the appropriation of collective spaces, much more emotional rather than racional, where a simple pair of chairs and a table placed on the outside can turn its public space (the distributive corridor) into na exterior dinning área.
This is also the case of the ilhas from the Fontaínhas neighborhood, the place chosen as the intervention site for the present work.
These three ilhas were established in support of the ceramic factory that was once there. A factory that nowadays is no more than ruins. The three ilhas are named as Ilha da Tapada, Ilha Maria Vitorina and Ilha Olimpia. Together they land on top of the Fontainhas Hill. This riverside site of Oporto can be found, nowadays, in a devolute state, where most houses of the ilha typology are in a severe degradation state, presenting salubrity problems and few living conditions.
This territory, which overlooks the Douro river presents severe urban planning and architectural issues, in which this paper intends to study in order to develop solutions capable of regenerating and revitalize a degraded area of this city; to qualify the urban space and offer continuity and coherence to this riverside area; to rehabilitate the precarious state of the remaining buildings and return them to their original inhabitants, also creating more affordable housing conditions, striking the lack of dwellings in such dignifying sites.<br>N/A
8
Delaitre, Pascale. "Préparation fonctionnelle respiratoire et chirurgie colique." Montpellier 1, 1988. http://www.theses.fr/1988MON11164.
Full text
9
Ferreira, Sandra Cristina da Silva. "Colite pseudomembranosa associada aos antibacterianos." Master's thesis, [s.n.], 2013. http://hdl.handle.net/10284/3986.
Full textAbstract:
Projeto de Pós-Graduação/Dissertação apresentado à Universidade Fernando Pessoa como parte dos requisitos para obtenção do grau de Mestre em Ciências Farmacêuticas<br>Os antibióticos antibacterianos têm um tropismo para as células procariotas, exercendo a sua ação bactericida ou bacteriostática sobre estas. No entanto, apesar da sua especificidade, os antibióticos podem ter efeitos tóxicos nas células humanas, dando origem às reações adversas. A colite pseudomembranosa foi descrita pela primeira vez em 1893 por Finney, sendo uma doença infeciosa que surge geralmente na sequência de antibioterapia prévia, tendo como principal agente etiológico o Clostridium difficile. Esta trata-se de uma entidade com taxa de mortalidade elevada, rondando os 20 a 30% e onde as recorrências são comuns. A infeção por C.difficile é das mais incidentes adquiridas em indivíduos hospitalizados.
Os antibióticos provocam a alteração da flora intestinal normal permitindo a colonização pelo C.difficile, que em condições apropriadas leva à ocorrência de sintomatologia. Os antibióticos mais implicados são os de largo espetro, tendo-se como exemplo as penicilinas associadas a beta lactamases e a clindamicina, possuindo estes um largo impacto na microbiota intestinal.
Existem vários métodos de diagnóstico laboratorial para testar amostras fecais à procura dos bacilos e/ou suas toxinas para confirmação deste tipo de infeção, bem como métodos de visualização direta e estudos de imagem abdominal (diagnóstico clínico). No que respeita ao tratamento, a vancomicina e o metronidazol são os fármacos mais utilizados na infeção por C.difficile, havendo variações conforme a gravidade da doença.
Embora a maioria das infeções respondam à terapêutica disponível, a infeção pode aumentar a morbilidade, prolongar a hospitalização, e mesmo colocar a vida do doente em risco, pelo que o uso racional dos antibacterianos é de extrema importância, bem como as restantes medidas de prevenção.
Antibacterial antibiotics have a tropism for prokaryotic cells, exerting its bactericidal or bacteriostatic on these. However, despite of their specificity, antibiotics can have toxic effects on human cells, giving rise to adverse reactions. Pseudomembranous colitis was described in 1893 by Finney, being an infectious disease that usually appears as a result of antibiotic treatment, the main etiological agent Clostridium difficile. This is an illness with a high mortality rate, around 20-30% and where recurrences are common. Infection with C. difficile is the most incident acquired in hospitalized individuals.
Antibiotics cause alteration of the normal intestinal flora allowing colonization by C. difficile, which under appropriate conditions leads to the occurrence of symptoms. The antibiotics most commonly involved are broad spectrum, for example penicillins associated with beta lactamases and clindamycin, possessing such a large impact on the intestinal microbiota.
There are several methods of laboratory diagnosis to test fecal samples in search of bacilli and / or their toxins to confirm this type of infection, as well as methods of direct visualization and abdominal imaging studies (clinical diagnosis). With regard to treatment, vancomycin and metronidazole are the most commonly drugs used for the C. difficile infection, with variations depending on the severity of the disease.
Although the majority of infections respond to therapy available, the infection can increase morbidity, prolonged hospitalization, and even life-threatening patient, whereby the rational use of antibacterial agents is extremely important as well as preventive measures remaining.
10
Gonçalves, João Paulo Chatué. "Habitar a flexibilidade na colina." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2018. http://hdl.handle.net/10400.5/17996.
Full textAbstract:
Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Arquitetura apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.<br>A flexibilidade será o mote para o renascer do Colégio de Santo Antão o Novo,
um modo de habitar e de fazer habitação que é, de acordo com o objetivo estruturado,
uma proposta de futuro para o lugar, que tal como ele, se transforma e adapta ao
longo do tempo. Pretende-se com este trabalho compreender os modos de habitar a
fl exibilidade, assim como a sua polivalência e adaptabilidade.
Projetar a fl exibilidade é entender o futuro uso do espaço, dar-lhe a capacidade
de se transformar ao longo do tempo, construir para o desconhecido, procurando acolher
e adaptar-se perante as diferentes apropriações ao longo do tempo, é transformar o
habitante num encenador do espaço habitado, dando-lhe as linhas orientadores para
transformar o espaço à sua necessidade.
O estudo de uma habitação capaz de se adaptar aos vários modos de vida
atuais, é suportado por um conhecimento geral da sociedade. A diversidade existente
numa sociedade cada vez mais global, leva-nos a repensar o modo como habitamos e
fazemos habitar. Sugere-se a criação de uma habitação alternativa com foco para as
zonas privadas, mas também com uma forte componente de comunidade, com espaços
de partilha e reunião, inserindo-se no espírito académico que a rodeia.
Assim, este trabalho pretende recolher metodologias e princípios que visem a
efi ciência da fl exibilidade aplicando-as no conjunto construído do Hospital de São José.
Assente numa proposta que procura estabelecer as relações entre passado, presente
e futuro, o conceito pretende desenvolver um tipo de habitar capaz de se adaptar ao
habitante conforme as suas necessidades se alteram ao longo do dia.
Este lugar, sujeito ao longo dos séculos a várias transformações, assistirá agora
a uma última que o pretende capacitar com as peças necessárias para se adaptar às
necessidades futuras, enquadrando-o num complexo multifuncional que servirá de apoio
à futura Universidade.<br>ABSTRACT: Flexibility as a starting point for the rebirth of the new “Colégio de Santo Antão o
Novo”, a way of living and to housing that is in accordance with the structured objective,
a proposal for the future of the place, wich like him, transforms and adapts over time. This
work intends to understand the ways of inhabiting fl exibility, as well as its versatility and
adaptability.
Design fl exibility is to understand the future use of space, give it the ability to
transform over time, build into the unknown, seeking to accommodate and adapt to the
different appropriations over time, is to transform the inhabitant in a director of the inhabited
space, giving him the guidelines to transform the space into your need.
The study of a housing capable of adapting to the presente various ways of life, is
supported by a general knowledge of society. The diversity that exists in an increasingly
global society, leads us to rethink the way we live and inhabit. I tis suggested to create
na alternative housing with a focus on the private areas, but also with a strong community
component, with sharing and meeting spaces, inserting itself in the academic spirit that
surrounds it..
Thus, this work intends to collect methodologies and principles that aim at the
effi ciency of fl exibility, applying them in the set constructed of Hospital de São José. Based
on a proposal to establish the relationships between past, present and future, the concept
aims to develop a type of dwelling able to adapt to the inhabitant as their needs change
throughout the day.
This place, subject over the centuries to various transformations, will now attend to
a last one that intends to equip it with the necessary pieces to adapt to the future needs,
framing it in a multifunctional complex that will serve as a support for future University.<br>N/A
11
Gonçalves, Marisa Diana Ferreira. "Habitar o pátio na colina." Master's thesis, Universidade de Lisboa, Faculdade de Arquitetura, 2019. http://hdl.handle.net/10400.5/20120.
Full textAbstract:
Dissertação de Mestrado Integrado em Arquitetura, com a especialização em Interiores e Reabilitação do Edificado apresentada na Faculdade de Arquitetura da Universidade de Lisboa para obtenção do grau de Mestre.<br>Este Trabalho Final de Mestrado incide sobre a temática da habitação operária, mais concretamente, os pátios e vilas na cidade de Lisboa, testemunhos materiais de uma forma de habitar a cidade característica da industrialização que marcou Portugal a partir de meados do século XIX. Este tipo de edificado faz parte do passado e do presente da história da cidade de Lisboa e contém uma incontornável carga simbólica na malha urbana da cidade. A sua origem provém de soluções habitacionais destinadas a operários que migraram do meio rural para a urbe à procura de trabalho nas indústrias e, sobretudo, de uma melhor qualidade de vida. Porém, encontramos nestes lugares ocultos da cidade que se inserem maioritariamente dentro de quarteirões, uma vida social que se baseava em relações de interajuda. O pátio é, portanto, um elemento congregador utilizado como uma extensão da casa.
O lugar de análise e intervenção é o Pátio de Dom Fradique que se integra na malha urbana de Alfama, especificamente adjacente ao Palácio Belmonte e contíguo ao Convento Menino de Deus. Propomos o desenvolvimento de uma solução urbana e arquitetónica que pretende contribuir para a sua revitalização social e arquitetónica, por via da valorização do seu valor identitário através da introdução de novos usos que visam conferir vida e urbanidade, satisfação e otimização da casa e das relações interpessoais.<br>ABSTRACT: This Master’s degree final project focuses on the theme of working class’ housing, specifically the pátios and vilas from the city of Lisbon, and testimonies of the way of living in the city resultant from the industrialization of Portugal in the XIX century. This type of construction is part of the past and present history from the city of Lisbon and is a symbolic representation of the city’s urban network. Its’ origin comes from living solutions destinated for the working class, who move from the countryside to a big city searching for better work opportunities and to improve their life quality. However, due to the fact of these places being away from the city and grouped within blocks we can find a social life ruled by mutual help, with the patio being a place of gathering and used as an extension of the house.
The place of analysing and intervening is Pátio de Dom Fradique, which is integrated within the urban area of Alfama, next to Palácio Belmonte and contiguous to the Convento Menino de Deus. We propose the development of an urban and architectural solution that contributes to its social and architectural revitalization, through the enhancement of its identity value through the introduction of new uses that confers life and urbanity, satisfaction and optimization of the house and interpersonal relationships.<br>N/A
12
Darras, Stéphanie Paineau Jacques. "Colite ischémique après chirurgie cardiovasculaire." [S.l.] : [s.n.], 2006. http://theses.univ-nantes.fr/thesemed/SPEdarras.pdf.
Full text
13
RACLOT, GILLES. "Prostanoides, colites collagene et lymphocytaire." Besançon, 1992. http://www.theses.fr/1992BESA3036.
Full text
14
Sabbagh, Charles. "Prise en charge de l'occlusion colique tumorale." Thesis, Amiens, 2015. http://www.theses.fr/2015AMIE0008/document.
Full textAbstract:
L’occlusion colique est le mode de révélation de 8 à 29% des cancers du colon. Elle révèle undiagnostic tardif associé le plus souvent à une tumeur localement avancée ou métastatique. Laprise en charge, en urgence, de ces cancers est donc cruciale et doit intégrer l’évaluation del’état général du patient (âge, comorbidités, état nutritionnel), et le stade de la maladie quiauront un impact direct sur les résultats postopératoires précoces et à distance. Les optionsthérapeutiques disponibles pour la prise en charge en urgence de ces tumeurs sontchirurgicales (colostomie de décharge, intervention de Hartmann, colectomie segmentaireavec ou sans lavage per opératoire avec anastomose colorectale, colectomie totale avecanastomose iléorectale) ou endoscopique (prothèse colique).Les objectifs de cette thèse étaient d’évaluer l’impact de la prothèse colique sur la prise encharge à visée curative des cancers coliques en occlusion, l’étude des donnéesanatomopathologiques afin d’expliquer les différences de survie en fonction de la stratégiethérapeutique et l’élaboration de recommandations françaises et européennes afin de préciserla place de la prothèse colique dans la prise en charge des cancers coliques en occlusion<br>The colonic obstruction is the mode of revelation of 8 to 29% of colon cancers. It reveals latediagnosis most often associated with a tumor locally advanced or metastatic disease. Themanagement, in an emergency, of these cancers is crucial and must include the evaluation ofthe patient's general condition (age, comorbidities, nutritional status), and the stage of thedisease that will have a direct impact on early and late postoperative outcomes. Treatmentoptions available totreat in emergency these tumors are surgical (colostomy, Hartmannprocedure, segmental colectomy with or without intraoperative lavage with colorectalanastomosis, total colectomy with ileorectal anastomosis) or endoscopic (colonic stent).The objectives of this thesis were to assess the impact of the colonic stent in the curativemanagement of obstructive colonic cancer, to study pathological data to explain differences insurvival according to treatment strategy and the development of French and Europeanrecommendations to clarify the role of colonic stent in the treatment of colon cancerocclusion
15
Aroca, Iniesta Francisco. "Le lyrisme dans la poésie d'Antonio Colinas." Paris 4, 2005. http://www.theses.fr/2005PA040189.
Full textAbstract:
Antonio Colinas (1946, La Bañeza, León) publie ses premiers recueils à la fin des années 60. De prime abord, le poète ne semble pas " rupturiste " au regard de l'époque, marquée par les mouvements d'avant-garde. Ses textes, pourtant, tout en mêlant tradition et modernité manifestent un renouveau dans la poésie espagnole. En dépit de sa simplicité, la langue poétique est extrêmement travaillée et surprend le lecteur par son intensité lyrique. Fidèle à son temps, Antonio Colinas évoque toute une époque, celle des années 70. L'Espagne septentrionale ou méridionale, l'Italie, l'Europe du Nord seront les espaces privilégiés du personnage poétique toujours en quête de son identité individuelle et par-delà d'une identité collective. Dans le lyrisme colinien, art, culture et vie ne sont au service que d'une seule et même exploration destinée à insuffler de nouvelles réalités dans l'espace poématique. La voix colinienne a également recours au rêve et au souvenir, individuel ou collectif, afin de récréer toutes les facettes de la réalité<br>Antonio Colinas (1946, La Bañeza, León) published his first poetry books at the end of the sixties. At first sight, his work does not seem to break with the prevalent avant-garde styles of the period. However, mixing tradition and modernity, his writing was a renewal of Spanish poetry. For all its apparent simplicity, the poetic language is very elaborate, and the reader is surprised by its lyrical intensity. A writer of his time, Antonio Colinas evokes a whole period, that of the seventies. Northern or Southern Spain, Italy and Northern Europe were the preferred regions of a poetic character always seeking both an individual identity and a parallel collective identity. In Colinien lyricism, art, culture and life are at the service of a unique exploration, the purpose of which is to allow new realities to infiltrate the poetic space. The Colinien voice resorts equally to both dreams and memories, individual and collective, in order to recreate all the facets of reality
16
DESTOMBES, DOROTHEE. "Septicemie a streptococques bovis et polypose colique." Lille 2, 1992. http://www.theses.fr/1992LIL2M171.
Full text
17
BENEYTO, LOUIS-CLAUDE. "La colique nephretique : etude realisee a l'hopital d'auch a propos de 100 cas." Toulouse 3, 1989. http://www.theses.fr/1989TOU31062.
Full text
18
DECREMPS, DANIELLE. "Coliques du nourrisson : revue de la litterature et proposition pour une conduite a tenir en pratique quotidienne." Toulouse 3, 1988. http://www.theses.fr/1988TOU31331.
Full text
19
Nery, Joana. "Influence de la taille sur la fonction colique et la tolérance digestive chez le chien." Nantes, 2009. http://www.theses.fr/2009NANT2050.
Full textAbstract:
Le dioxyde de titane, connu pour ses applications dans les domaines de la photoactivité et du photovoltaïque, est aussi un candidat d’électrode négative pour batteries lithium-ion. Les variétés anatase et TiO2(B) sont les plus prometteuses. Leurs capacités sont respectivement de 0,50 et 0,75 Li+ par motif de TiO2. Sous forme nanométrique, elles présentent des densités d’énergie et de puissance accrues. L’objet de ce travail de thèse concerne la synthèse par chimie douce de dioxydes de titane nanométriques selon la méthode développée initialement par Kasuga et al. Et leur caractérisation. La méthode en trois étapes génère successivement deux intermédiaires tels que (i) le titanate (NaOH)xTiO2(H2O)y (x = 0,3-0,5 et y = 0,4-0,7) par reflux, et (ii) l’acide titanique TiO2(H2O)z (z = 0,7-0,8) après échange ionique, et finalement, après recuit, (iii) le TiO2 de morphologie proche de celle du titanate précurseur. Quatre titanates de sodium ont été identifiés, trois structures lamellaires, se différenciant par leur morphologie (nanotubes, semi-nanotubes et nanorubans) et une structure amorphe s’apparentant à des nanosphères. Après échange ionique et recuit, les nanotubes et les nanosphères se transforment en anatase, les semi-nanotubes en un mélange d’anatase et de TiO2(B), et les nanorubans en TiO2(B) exclusivement. La quantification par spectroscopie Raman du ratio anatase/TiO2(B) a été développée en calibrant les intensités avec les résultats d’électrochimie. Enfin, les nanorubans de TiO2(B) ont été testés au sein de demi-batterie lithium métal. Les performances sont prometteuses avec une capacité réversible de 200 mAh. G-1 à C/3 (soit 0,6 Li+ par TiO2) et de 100 mAh. G-1 à C/15<br>Titanium dioxide, well-known for its applications in the field of the photoactivity and the dye sensitized solar cells, is also a promising candidate as a negative electrode for lithium-ion batteries. Anatase and TiO2(B) varieties are the most interesting ones, with electrochemical intercalations of 0. 50 and 0. 75 Li+ per TiO2 respectively. In nanometric sizes, these varieties exhibit higher energy and power densities. This study is focused on the synthesis of nanometric titanium dioxides by a soft chemistry way first developed by Kasuga et al. The three step method generates successively intermediates such as (i) titanate (NaOH)xTiO2(H2O)y (x = 0,3-0,5 et y = 0,4-0,7) by reflux treatment and (ii) titanic acid TiO2(H2O)z (z = 0,7-0,8) after ionic exchange and finally, after thermolysis, (iii) TiO2 with the same morphologies as the titanate precursors ones. Four types of sodium titanates were identified, three lamellar structures (nanotubes, semi-nanotubes and nanoribbons) and an amorphous nanosphères-like one. After ion exchange and annealing, nanotubes and nanospheres transform into anatase at 400°C and 500°C respectively, semi-nanotubes in a mixture of anatase and TiO2(B), and nanoribbons condense into TiO2(B) exclusively at around 400°C. The quantification of the anatase/TiO2(B) ratio by Raman spectroscopy was obtained by calibrating the intensity using electrochemistry. Finally, nanoribbons of TiO2(B) were tested in half lithium metal cells. They exhibit promising performance with a reversible capacity of 200 mAh. G-1 at C/3 (i. E. 0. 6 Li+ per TiO2) and 100 mAh. G-1 at C/15
20
Santos, Miguel Ângelo Medeiros dos. "Novas abordagens terapêuticas na colite ulcerosa." Master's thesis, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62188.
Full text
21
Santos, Miguel Ângelo Medeiros dos. "Novas abordagens terapêuticas na colite ulcerosa." Dissertação, Instituto de Ciências Biomédicas Abel Salazar, 2010. http://hdl.handle.net/10216/62188.
Full text
22
CONNAN, LAURENT. "La tuberculose colique : a propos de 2 observations." Angers, 1990. http://www.theses.fr/1990ANGE1111.
Full text
23
Jiménez, Arriaza Franco. "Tratado e la pintura callejera : injustiticia de Colihue." Tesis, Universidad de Chile, 2014. http://www.repositorio.uchile.cl/handle/2250/129654.
Full text
24
CHMAIT, AKRAM. "Perforations de diverticulose colique lors de traitements corticoides." Amiens, 1993. http://www.theses.fr/1993AMIEM108.
Full text
25
MERLET, STEPHANE. "Prise en charge diagnostique et therapeutique de la colique nephretique dans un service d'urgence." Nantes, 1994. http://www.theses.fr/1994NANT007M.
Full text
26
MOLENAT, FLORENCE. "Effet du bifidus sur le temps de transit colique : etude sur le volontaire sain." Aix-Marseille 2, 1993. http://www.theses.fr/1993AIX20810.
Full text
27
Guillemette, Eric. "Les coliques nephretique simples dans les services d'urgence : a propos d'une etude realisee au centre hospitalier et universitaire de dijon." Dijon, 1994. http://www.theses.fr/1994DIJOM058.
Full text
28
CAROLET, FOURMET CAROLE. "Reflexions sur la prise en charge des coliques nephretiques en urgence : experience d'un an au chr de reims." Reims, 1989. http://www.theses.fr/1989REIMM074.
Full text
29
Eribon, Olivier. "Analyse automatique du signal electromyographique intestino-colique par méthodes fractales. Application à l'étude de la motricité intestino-colique chez l'animal et l'homme." Chambéry, 1996. http://www.theses.fr/1996CHAMS037.
Full textAbstract:
Le tractus intestino-colique est un organe multifonctionnel où la motricité joue un rôle physiologique déterminant. L’objectif du travail réside dans la mise au point d'un système de recueil, de traitement et d'analyse du signal electromyographique intestino-colique de l'homme capté par des électrodes interpariétales ou endoluminales. Ce système procède à l'extraction automatique des salves de potentiels du signal electromyographique de l'intestin grêle. Il est auto-adaptable aux spécificités du signal selon les niveaux digestifs explores et/ou l'espèce animal étudiée. L’analyse du signal electromyographique digestif s'effectue selon deux modes: soit sur la salve de potentiels seule (correspondant à une contraction) après son extraction, soit sur le signal electromyographique global. Cette dernière approche permet une analyse rapide des informations recueillies. La caractérisation des activités electromyographiques est effectuée à l'aide de neuf paramètres de différentes natures et constitue ainsi un système relativement robuste et adaptable. L’approche fractale entreprise se révèle véritablement adaptée au signal electromyographique digestif. Elle permet de s'affranchir des difficultés liées à l'étalonnage de la chaine de mesure. Les résultats obtenus montrent que la dimension fractale représente un indicateur simple mais pertinent de caractérisation, permettant une classification des activités electromyographiques digestives
30
Vasconcelos, Roberta Juliana Costa. "Suplementação de colina em dietas para poedeiras." Universidade Federal de Minas Gerais, 2013. http://hdl.handle.net/1843/BUBD-9DFJ58.
Full textAbstract:
In order to evaluate the effect of supplementation levels of choline in diets for laying hens on performance, internal and external quality of eggs and macro and microscopic analysis of livers an experiment was conducted in two phases. In the first phase was to study the effect of choline supplementation on the performance of one to 14 weeks of age. We used 2240 pullets Dekalb White, housed in a shelter conventional. The experimental design was completely randomized design with two treatments and 14 repetitions of 80 birds per experimental unit. Diets isonutrient, except the levels of choline. The treatments were defined by the levels of choline supplementation. There was no difference between treatments (p> 0.05), F test, the body weight, feed intake, feed conversion and viability, or for the macro and microscopic features of liver by the Mann-Whitney. In the second phase, the effect of the levels of choline supplementation on broiler performance, macro and microscopic analysis of livers of poultry and egg quality during production. 1800 birds were used in the 18 weeks of age from phase I. The experimental design was completely randomized in a factorial 2x5 (two levels of choline supplementation phases: initial and re-x five levels of choline supplementation on laying phase) with six replicates of 30 birds each. Diets isonutrient, except the levels of choline. The treatments were defined by the levels of choline supplementation. There was no difference between treatments (p> 0.05), F test, as the feed and the number of eggs per bird housed. The daily egg production was observed interaction of choline supplementation in the growing phase, with levels of choline in the production phase (p 0.05). Positive linear effect was obtained when the diets were supplemented with choline in the growing phase, when it was made to supplement this phase, there was a linear effect. The weight of the birds, feed intake and viability there was no interaction (p 0.05). For macroscopic and microscopic evaluation of liver phase I, the design was completely randomized design with two treatments (with and without choline supplementation) with eight replications, each bird was considered a recurrence. For macroscopic and microscopic evaluations of the livers of the experimental phase II was randomized in a factorial 2x5 (2 levels of choline supplementation phases: initial and re-x 5 levels of choline supplementation on laying phase) with four replications , and each liver was considered as a repetition. There was no statistical difference (p> 0.05) for any variable. For the evaluation of the quality of the eggs was the same design used for the benchmarks, except for the number of replications was 30, and each egg was considered as one repetition. There was no interaction between choline supplementation in growing and choline levels in the laying stage for any of the variables observed, except the percentage of shell.<br>Com o objetivo de avaliar o efeito dos níveis de suplementação de colina em dietas para poedeiras sobre o desempenho, qualidade interna e externa dos ovos e análise macro e microscópica dos fígados foi realizado um experimento dividido em duas fases. Na primeira fase foi avaliada a influência da suplementação de colina sobre o desempenho de uma a 14 semanas de idade. Foram utilizadas 2240 aves da linhagem Dekalb White, alojadas em galpão convencional. O delineamento experimental foi inteiramente casualizado, com dois tratamentos e 14 repetições de 80 aves por unidade experimental. As rações foram isonutritivas, com exceção dos níveis de colina. Os tratamentos foram definidos pelos níveis de suplementação de colina. Não foi observada diferença entre os tratamentos (p>0,05), pelo teste F, quanto ao peso corporal, consumo de ração, conversão alimentar e viabilidade, nem para as características macro e microscópicas dos fígados pelo teste de Mann-Withney. Na segunda fase foi avaliado o efeito dos níveis de suplementação de colina no desempenho das aves, análises macro e microscópicas dos fígados das aves e qualidade dos ovos na fase de produção. Foram utilizadas 1800 aves da com 18 semanas de idade provenientes da fase experimental I. O delineamento experimental foi inteiramente ao acaso em esquema fatorial 2x5 (dois níveis de suplementação de colina nas fases: inicial e recria x cinco níveis de suplementação colina na fase de postura) com seis repetições de 30 aves cada. As rações foram isonutritivas, com exceção dos níveis de colina. Os tratamentos foram definidos pelos níveis de suplementação de colina. Não foi observada diferença entre os tratamentos (p>0,05), pelo teste F, quanto à conversão alimentar e ao número de ovos por ave alojada. Quanto à produção diária de ovos foi observada interação da suplementação de colina na fase de recria, com os níveis de colina na fase de produção, (p0,05). Efeito linear positivo foi obtido quando as rações foram suplementadas com colina na fase de recria, quando não foi feita a suplementação nessa fase, observou-se efeito linear negativo. Quanto ao peso das aves, consumo diário de ração e viabilidade não houve interação (p0,05). Para a avaliação macro e microscópica dos fígados da fase I, o delineamento foi, inteiramente ao acaso com dois tratamentos (com e sem suplementação de colina) com oito repetições cada, sendo que cada ave foi considerada a repetição. Para as avaliações macro e microscópica dos fígados o delineamento experimental da fase II foi inteiramente ao acaso em esquema fatorial 2x5 (2 níveis de suplementação de colina nas fases: inicial e recria x 5 níveis de suplementação colina na fase de postura), com quatro repetições, sendo que cada fígado foi considerado como uma repetição. Não foi observada diferença estatística (p>0,05) para nenhuma das variáveis. Para as avaliações da qualidade dos ovos o delineamento foi o mesmo utilizado para as avaliações de desempenho, com exceção do número de repetições que foi de 30, sendo que cada ovo foi considerado como uma repetição. Não houve interação entre suplementação de colina na recria e os níveis de colina na fase de postura para nenhuma das variáveis observadas, com exceção da porcentagem de casca.
31
Delmond, Christine Liquière. "La colite collagène et les pathologies associées." Montpellier 1, 1988. http://www.theses.fr/1988MON11225.
Full text
32
Tandonnet, Marie Agnès Alice Augusta. "Colite pseudo-membraneuse : à propos d'un cas." Bordeaux 2, 1994. http://www.theses.fr/1994BOR2M003.
Full text
33
BENARD, CLAUDINE. "Effets des polysaccharides sulfates d'algues sur la muqueuse colique." Nantes, 1998. http://www.theses.fr/1998NANT2078.
Full textAbstract:
Les macroalgues sont une source de fibres alimentaires. Ces fibres algales peuvent etre sulfatees (ulvanes, carraghenanes). Les ulvanes, peu exploitees, sont consommees comme legumes tandis que les carraghenanes sont utilises comme additifs alimentaires. Alors que les ulvanes ont des activites biologiques inconnues, les carraghenanes degrades (40 kda) sont capables d'induire des ulcerations coliques chez les animaux de laboratoire. L'objectif de ce travail etait dans un premier temps, d'etudier l'effet d'ulvanes natifs et desulfates sur la proliferation de cellules epitheliales coliques en culture (ht-29). Dans un second temps, nous avons analyse differents facteurs (flore colique, cellules epitheliales et immunitaires) potentiellement impliques dans le developpement de l'ulceration colique chez le rat, afin de comprendre le ou les mecanismes d'action. Les ulvanes natifs stimulaient la proliferation des cellules ht-29, cependant les groupements sulfates exercaient un effet regulateur de cet effet. Deux preparations de carraghenanes degrades de masse molaire moyenne de 10 et 40 kda ont ete realisees. Dans la deuxieme preparation, seulement 30% des carraghenanes avait une masse molaire de 40 kda, les 70% restantes avait une masse molaire de 10 kda. Apres 55 jours, les carraghenanes de 40 kda induisaient une ulceration du colon distal et du rectum chez le rat, tandis que ceux de 10 kda n'induisaient qu'une hyperhemie rectale. In vitro, les carraghenanes presentaient un comportement fermentaire identique caracterise par un temps de latence de 8 h, et produisaient a 48 h des concentrations de sulfure d'hydrogene similaires. Les carraghenanes de 40 kda n'etaient pas toxiques pour les cellules ht-29. En revanche, les deux preparations stimulaient l'expression de la molecule d'adhesion icam-1 a la surface de monocytes en culture et provoquaient leur agregation. Les carraghenanes n'avaient pas d'effet sur les lymphocytes t. Ces resultats suggerent une participation de la flore (induction d'enzymes bacteriennes et desulfatation) et du systeme immunitaire (recrutement des macrophages) dans l'induction et/ou le developpement de l'inflammation. L'implication des cellules epitheliales n'a pas ete mise en evidence.
34
RENAUX, JEAN-PIERRE. "Nutrition enterale cyclique et maladie de crohn ileo-colique." Amiens, 1988. http://www.theses.fr/1988AMIEM052.
Full text
35
Crenner, Agnès. "Physiopathologie de la motricite colique : apport de l'etude electromyographique." Université Louis Pasteur (Strasbourg) (1971-2008), 1985. http://www.theses.fr/1985STR1M047.
Full text
36
Laibe, Sophy. "Analyse génomique intégrée du cancer colique et impact thérapeutique." Thesis, Aix-Marseille, 2013. http://www.theses.fr/2013AIXM5088.
Full textAbstract:
Le cancer du côlon (CC) est le 3ème cancer le plus fréquent en France avec plus de 40 000 nouveaux cas diagnostiqués par an. Vingt-cinq à 40% des CC sont diagnostiqués à un stade II. La majorité des CC de stade II ne nécessite pas de traitement adjuvant par chimiothérapie, cependant, environ 20% de ces patients vont évoluer avec l'apparition de métastases viscérales. Or, seuls les facteurs histopathologiques ou la détermination du statut avec instabilité des microsatellites (type MSI) permettent d’orienter ou non vers une chimiothérapie complémentaire à la chirurgie. La majorité des CC de stade II ont un profil avec stabilité des microsatellites (type MSS) et les facteurs pronostiques actuels sont mal définis. La découverte de marqueurs pronostiques pour ces patients est donc un enjeu majeur de la prise en charge du CC. De cette façon, notre équipe a mis en évidence l’existence d’une signature moléculaire sur 166 tumeurs, portant sur l’expression différentielle de 7 gènes, entre les tumeurs de CC de stade II et les tumeurs de CC de stade III. Ensuite, le statut mutationnel des gènes KRAS et BRAF, effectué sur 803 CC métastatiques, a mis en évidence que la mutation BRAF V600E est principalement associée au CC de type MSS suggérant un impact pronostique négatif. Enfin, l’étude du statut du gène APC (mutations, LOH, hyperméthylation du promoteur) sur 183 CC de stade II montre que ce gène n’est vraisemblablement pas impliqué dans le développement de métastases du CC. En perspective de ce travail, l’arrivée de techniques de séquençage de nouvelle génération permet d’envisager un traitement adapté à la tumeur, orientant vers une médecine personnalisée<br>Colon cancer (CC) is the third most common cancer in France with 40000 new cases diagnosed every year. For thirty years, death-rate has decreased through better therapeutic and screening management, and 40% of CC are diagnosed of stage II. Most of stage II CC do not require chemiotherapy adjuva,t to surgical resection. About 20% of patients with stage II CC relapse within 5 years following the diagnosis. Except microsatelitte instability (MSI) incombination with few hispathologic parameters, the molecular prognosis factors are not well defined and remain a major biological challenge in stage II CC. Our study analyzed the molecular signature of 166 tumors and determined the different expression of seven genes between stage II and stage III CC. KRAS and BRAF mutations were determined on 803 metastatic CC showing an association between V600E BRAF mutation and tumors with microsatellite stability (MSS). This result suggests a negative prognostic impact of BRAF mutation in MSS CC. Finally, the APC gene statut (mutations, LOH, promoter hypermethylation) of 183 stage II CC shows that this gene is probably not involved in the metastatic process. Further developments will consist in applying the next generation sequencing to allow the simultaneous analysis of hundreds target genes. In this way, the treatment will be adapted to each tumor, moving towards personalized medicine
37
Accarie, Alison. "Etudes des mécanismes impliqués dans l'hypersensibilité viscérale d'origine colique." Thesis, Clermont-Ferrand 1, 2015. http://www.theses.fr/2015CLF1MM04.
Full textAbstract:
Les douleurs abdominales, principale cause de consultation en gastroentérologie, sont souvent le reflet d’un dysfonctionnement du tractus gastro‐intestinal, parfois responsable d’un Syndrome de l’Intestin Irritable (SII) ou d’une Maladie Inflammatoire Chronique de l’Intestin (MICI). Ces deux types de pathologies ont des caractéristiques bien distinctes (inflammation sévère avec des phases de poussée et de rémission dans le cas des MICI, absentes dans le SII). Cependant elles ont aussi des caractéristiques communes comme le développement d’une hypersensibilité colique (HSC), visible pendant les phases de rémission des MICI. Cette hypersensibilité, dont la physiopathologie est encore mal connue, entraîne une altération de la qualité de vie des patients. Il paraît donc nécessaire de comprendre les mécanismes qui sous‐tendent son apparition, son développement et son maintien, afin de développer des stratégies thérapeutiques adaptées. Les canaux ioniques sont des cibles intéressantes pour cela. Deux ont particulièrement retenu notre attention : le canal ASIC3 (Acid Sensing Ion Channels), sensible à l’acidose tissulaire et impliqué dans de nombreux processus physiopathologiques douloureux et le canal calcique Cav3.2 (voltage‐gated calcium channel) impliqué dans la mécanoperception physiologique et physiopathologique. Dans une première partie, nous avons évalué le rôle des sous‐unités ASIC3 dans l’hypersensibilité colique. Pour cela, nous avons utilisé plusieurs modèles animaux mimant une hypersensibilité colique de diverses origines chez des animaux déficients pour le canal ASIC3 et leurs littermates. Le premier modèle utilisait du DSS à deux concentrations : 0.5% et 1% induisant une hypersensibilité colique respectivement sans et avec inflammation. Le deuxième modèle mimait une hypersensibilité colique induite par une infection gastro‐intestinale. Pour cela, nous avons utilisé une bactérie AIEC (Adherent Invasive Escerichia Coli) de souche LF82 anormalement présente chez les patients atteints de la maladie de Crohn. Nous avons mis en évidence que le canal ASIC3 est impliqué dans la mise en place de l’Hypersensibilité Viscérale d’origine Colique (HSVC) dans ces deux modèles, et que la délétion de cette sous‐unité entraîne une moindre inflammation colique. Dans un dernier modèle, pour déterminer si ces résultats au niveau colique étaient transposables au cas d’une hypersensibilté viscérale d’origine différente, nous avons choisi un modèle de cystite pour lequel nous n’avons pas pu mettre en évidence une implication de la sous‐unité ASIC3. Dans une deuxième partie, nous avons travaillé sur le canal calcique Cav3.2, déjà étudié au laboratoire, et qui n’avait pas montré d’implication dans les douleurs viscérales inflammatoires. Son implication dans l’HSC non inflammatoire a été étudiée à travers deux modèles : le modèle de DSS 0.5% et le modèle de séparation maternelle. Une absence d’hypersensibilité chez les animaux déficients pour ce canal a été mise en évidence, et nous avons trouvé une implication de ce canal calcique chez des patients atteints du SII. La dernière partie de ce travail s’est intéressée à une nouvelle cible pouvant être impliquée dans la perception des stimuli mécaniques au niveau colique, le facteur de transcription EGR‐4. Ce facteur de transcription appartient à la famille des protéines en doigts de zinc et est extrêmement conservé entre les êtres vivants ; il est impliqué dans de nombreuses cascades de signalisations cellulaires. Une équipe clermontoise a montré son implication dans la mécanoperception chez la plante. Nous avons donc voulu savoir si cette implication était transposable à la souris et nos travaux se sont alors concentrés sur le côlon et sur l’implication de ce facteur lors d’une stimulation mécanique. Il est principalement exprimé au niveau des cellules musculaires lisses et est surexprimé au niveau du côlon dans le cas d’une stimulation mécanique<br>Abdominal pain is one of the most common gastrointestinal disorder which accounts for the majority ofconsultations in general practice and half of those in gastroenterology. They often reflect a dysfunction ofthe gastrointestinal tract may be responsible for irritable bowel syndrome (IBS) or chronic inflammatorybowel disease (IBD). Despite significant differences particularly illustrated by a severe inflammatoryphenomenon associated with IBD which is not observed in IBS, these pathologies share colonichypersensitivity (CHS) as a common feature. This hypersensitivity whose pathophysiology is still poorlyunderstood, results in impaired quality of life of patients. It therefore seems necessary to be able tounderstand the mechanisms that underlie the emergence, development and maintenance of the HSC todevelop appropriate therapeutic strategies. Ion channels are attractive targets because of their critical role insynaptic transmission of sensory information. Two of them in particular caught our attention: ASIC3 channel(Acid Sensing Ion Channels), sensitive to tissue acidosis and involved in many pathophysiological processesand painful calcium channel Cav3.2 (voltage‐gated calcium channel) involved in the physiologic andpathophysiologic mechanoperception.In the first part, we evaluated the role of ASIC3 subnits in colonic hypersensitivity. For this, we used severalanimal models mimicking colonic hypersensitivity of different origins in deficient animals for ASIC3 and theirlittermates. The first model using the DSS at two concentrations: 0.5% and 1% respectively inducing colonichypersensitivity with and without inflammation. The second model mimicking colonic hypersensitivityinduced gastrointestinal infection. For this, we used a AIEC bacteria (Adherent‐Invasive Escerichia Coli) ofLF82 strain abnormally present in patients with Crohn's disease. We were able to show that the ASIC3channel is involved in the establishment of the original Visceral Hypersensitivity Colic (HSVC) found in thesetwo models. We were also able to show that the deletion of this channel leads to lower colonic inflammationin our animals. Then, we evaluated its involvement in a cystitis model and found that this channel was notinvolved in this type of pain or in the resulting inflammation.In the second part, we worked on the calcium channel Cav3.2. This channel already studied in the laboratoryhad shown no involvement in visceral inflammatory pain, we observed his involvement in thenoninflammatory colonic hypersensitivity through two models: the DSS model 0.5% and the maternalseparation model. We were able to demonstrate a lack of hypersensitivity in animals deficient for thischannel. In addition, we found an involvement of this calcium channel in patients IBS, resulting in increasedexpression in these patients compared to control patients.The aim of this third part is to determine the EGR‐4 localization and its involvement in the mouse colonsensitivity to a mechanical stimulus. For that purpose, wild‐type and healthy mice were subjected or not to acolorectal distension (mechanical stimulus) for 10 seconds via inflation of a balloon inserted at 1cm from theanal margin. Then, we analyzed the expression of EGR‐4 at different time points after the distension at themRNA level in the colon, dorsal root ganglia (DRG) and spinal cord by quantitative RT‐PCR and its cellularlocalization in DRG, and in colon after whole‐mount dissection, by immunohistochemistry. We also identified targeted genes of this transcription factor in mouse colonic epithelial cells transfected by an EGR‐4expressing vector after microarray analysis. EGR‐4 transcription factor is localized in the colon, DRG andspinal cord cells. In addition, its expression is modified after colorectal distension in a time dependentmanner
38
Attar, Alain. "Analyses et modulations de la fermentation colique chez l'homme." Paris 7, 2007. http://www.theses.fr/2007PA077235.
Full textAbstract:
La fermentation colique des glucides complexe entraîne la production d'acides gras à chaîne courte (AGCC) et de gaz (CO2, H2 et plus rarement CH4). Les principaux AGCC (acétate, propionate et butyrate), exercent des effets majeurs en physiologie et en pathologie. Chez le sujet sain, nous avons montré que la flore colique pouvait être modulée par des prébiotiques (fructo-oligosaccharides et le lactulose) avec augmentation du niveau de population de Bifidobacteries En situation pathologique, nous avons montré que le lactulose n'était pas aussi efficace qu'un laxatif osmotique inerte métaboliquement mais avec des réserves quant à l'utilisation de ce dernier au long cours du fait des modifications de profil fermentaire de la flore. Nous avons également montré que la flore, en excès en cas de colonisation bactérienne chronique du grêle, pouvait être efficacement contrôlée par l'antibiothérapie mais que là aussi, l'effet à long terme d'une antibiothérapie séquentielle et prolongée n'était probablement pas souhaitable du fait des déséquilibres induits sur la flore colique. Comme les effets de ces interventions ont toujours été mesurés de façon indirecte, sur les selles ou les tests respiratoires, et du fait de l'impossibilité de l'étude fine de la fermentation intestinale là où elle se produit, le côlon droit, nous avons développé une technique innovante et originale de « dialyse in vivo » par fibres creuses permettant le recueil et l'analyse du liquide colique droit et montrant que la production des AGCC pouvait être mesurée avec description du profil fermentaire de la fibre étudiée<br>The colonic fermentation leads to the production of short chain fatty acids (SCFA), gas (CO2, H2 and rarely CH4). Main SCFA (acetate, propionate and butyrate) have tremendous effects in pathophysiology. In healthy volunteer, we showed that the colonic flora could be modulated by prebiotics (fructo- oligosaccharides and lactulose) with an increased in bifidobacteria genius. In diseases, we showed that lactulose was not as efficient as an inert osmotic laxative, provided that the long duration effect would not being deleterious according to the modification of fermentation. We also showed that the flora in excess in small intestinal bacterial overgrowth could be modulated efficiently by antibiotics with the exception that it may be also deleterious as it induces unbalance in the flora. As most of these interventions were done by indirect means in stools or with breath tests, because of colon inaccessibility, we developed an original method of in vivo dialysis by hollow fibers for the recovery of the lumen contents of right colon. We measured by this mean the production of SCFA with the description of the profile of fermentation of the studied fiber
39
Briat, Didier. "Ischemie colique et hemodialyse : a propos de trois observations." Clermont-Ferrand 1, 1989. http://www.theses.fr/1989CLF13028.
Full text
40
Barault, Ludovic. "Altérations génétiques et épigénétiques dans le cancer colique sporadique." Dijon, 2008. http://www.theses.fr/2008DIJOS025.
Full textAbstract:
Les cancers sont le plus souvent la conséquence d’un défaut des voies de régulations impliquées dans la survie ou la mort cellulaire. Nous avons pu démontrer sur une base de population de 586 adénocarcinomes coliques, suivis par le registre bourguignon des cancers digestifs que la mutation activatrice d’au moins un des trois gènes de la voie des MAP Kinases (KRAS, BRAF, PI3KCA) était associée a une moins bonne survie chez les patients porteurs d’une tumeur sans instabilité des microsatellites. Nous avons également analysé sur cette base de population la méthylation de l’ADN (caractérisation du phénotype « CpG Island Methylator Phenotype » CIMP). Trois groupes de méthylation ont été définis (No-CIMP, CIMP-Low, CIMP-High). Les cancers MSS/No-CIMP et MSS/CIMP-Low montraient des caractéristiques cliniques et génétiques similaires mais influençaient la survie de façon différente. Plus le niveau de méthylation était élevé, moins bonne était la survie des patients. Cette étude souligne l’effet pronostique péjoratif de la méthylation chez les patients MSS et la nécessité d’identifier les 3 groupes de méthylation. Ces travaux tirent leur importance de l’utilisation récente, dans le traitement du cancer, de thérapeutiques « dites ciblées » dirigées des protéines impliquées dans la transduction du signal du milieu extracellulaire vers le milieu intracellulaire. L’identification des mécanismes d’activation des voies de signalisation et la caractérisation des altérations épigénétiques impliquées dans le cancer colique représentent donc des étapes fondamentales dans la connaissance des facteurs moléculaires pouvant moduler la prise en charge thérapeutique des patients<br>Cancer cells are often the result of alterations in signalling pathways implicated in cell survival or apoptosis. We successfully demonstrated in a population base of 586 colon adenocarcinomas, followed by the cancer registry of Burgundy, that activating mutation of at least one of the three genes from the MAPK signalling pathway (KRAS, BRAF, PI3KCA) was associated with a lower survival in patients bearing a tumour without microsatellite instability. In a second study, DNA Methylation, an epigenetic alteration, was evaluated in the population base (characterization of the CpG Island Methylator Phenotype). Three subgroups of methylation phenotype were identified (No-CIMP, CIMP-Low, and CIMP-High). The clinico-pathological features of cancers with MSS/No-CIMP and MSS/CIMP-Low were quite similar, but they affected survival to different degrees. The higher the level of methylation, the poorer the survival. Our work clearly showed the prognostic effect of methylation in MSS patients and the need to distinguish between the 3 groups of CIMP. These studies are all the more important since the recent use of “targeted therapies” against proteins from the signal transduction system have recently been used in cancer treatment. The identification of activating mechanisms of signalling pathways and the characterisation of epigenetic alterations involved in colon cancer are fundamental to the understanding of the molecular factors involved in colorectal cancer. Knowledge of these will have an impact on patient response and follow-up
41
DEHONT, FRANCK. "Les colites a eosinophiles : a propos de 7 observations." Besançon, 1992. http://www.theses.fr/1992BESA3069.
Full text
42
Goes, Annya Costa Araújo de Macêdo. "A eletroacupuntura atenua a colite experimental induzida por TNBS via ativação de interleucina 10 e inibição de óxido nítrico sintase induzida." reponame:Repositório Institucional da UFC, 2014. http://www.repositorio.ufc.br/handle/riufc/8746.
Full textAbstract:
GOES, Annya Costa Araújo de Macêdo. A eletroacupuntura atenua a colite experimental induzida por TNBS via ativação de interleucina 10 e inibição de óxido nítrico sintase induzida. 2014. 113 f. Tese (Doutorado em Cirurgia) - Universidade Federal do Ceará. Faculdade de Medicina, Fortaleza, 2014.<br>Submitted by denise santos (denise.santos@ufc.br) on 2014-08-19T15:48:25Z
No. of bitstreams: 1
2014_tese_acamgoes.pdf: 19483930 bytes, checksum: f9454ee5a932df9cced9e223c7832892 (MD5)<br>Approved for entry into archive by denise santos(denise.santos@ufc.br) on 2014-08-19T15:48:51Z (GMT) No. of bitstreams: 1
2014_tese_acamgoes.pdf: 19483930 bytes, checksum: f9454ee5a932df9cced9e223c7832892 (MD5)<br>Made available in DSpace on 2014-08-19T15:48:51Z (GMT). No. of bitstreams: 1
2014_tese_acamgoes.pdf: 19483930 bytes, checksum: f9454ee5a932df9cced9e223c7832892 (MD5)
Previous issue date: 2014<br>The etiology of inflammatory bowel disease (IBD) involves genetic, environmental and immunological factors. There are clinical reports of the use of acupuncture on IBD, however its therapeutic mechanisms are still uncertain. The purpose of this work is to study the anti-inflammatory and analgesic actions of electroacupuncture on a experimental colitis model. Male Swiss rats, divided in six groups (n=6-9), were subjected to induction of colitis by TNBS in 50% ethanol. The controls were saline (SAL) and ethanol (ETNL). The animals with colitis were treated with electroacupuncture (EAC) at the ST-36 acupoint, 100Hz, false electroacupuncture (FEAC), 100Hz, and dexamethasone (DEXA), 1 mg/Kg/day. Visceral hyperalgesia was evaluated by means of the Von Frey test. After three days, a colon segment was obtained for macroscopic and histopathological analysis, quantification of the activity of myeloperoxidase, Immunohistochemistry for iNOS, and quantification of malondialdehyde and cytokines (TNF-α, IL-1β, IL-10). The parametric data were analyzed with ANOVA/Tukey test or test T, and the non-parametric data with Kruskal-Wallis/Dunn test. There was an increase on the wet weight of the colons on group TNBS, and prevention of this event on group EAC. The groups TNBS and EAC showed an increase on neutrophil infiltration, as compared to the other groups. The group TNBS showed increased values for the microscopic scores, as compared to the treated groups. The groups TNBS and EAC showed an increase on the concentration of IL-1β in the colon. The group TNBS showed suppression of the concentration of IL-10 in the colon, prevented by treatment with EAC. The group EAC showed decrease on the concentration of MDA in the colon, as compared to the other groups. The group EAC showed decrease on the expression of iNOS in the connective, as compared to the treated groups. The group TNBS did not show any alterations of hypernociception, as evaluated with Von Frey, at 24 and 72 hours. It can be therefore concluded that electroacupuncture, at the acupoint ST-36, 100Hz, showed anti-inflammatory action on the colitis induced by TNBS in 50% ethanol, by means of increase of IL-10 concentration and decrease on the expression of iNOS.<br>A etiopatogenia das doenças inflamatórias intestinais idiopáticas (DII) envolve fatores genéticos, ambientais e imunológicos. Há relatos do uso da acupuntura no tratamento da DII, porém seus mecanismos ainda são incertos. A proposta deste trabalho é estudar a ação antiinflamatória e analgésica da eletroacupuntura em modelo de colite experimental. Utilizaram-se camundongos machos Swiss, distribuídos em seis grupos (n=6-9), submetidos a indução de colite por TNBS em etanol a 50%. Os controles do modelo foram salina (SAL) e etanol (ETNL). Os animais com colite foram tratados com eletroacupuntura (EAC) no acuponto ST-36, 100Hz, falsa-eletroacupuntura (FEAC) 100Hz e dexametasona (DEXA) 1mg/Kg/dia. A hiperalgesia visceral foi avaliada pelo teste de Von Frey. Após três dias, foi coletado segmento de cólon para análises macroscópicas, histopatológicas (H-E), dosagem da atividade de mieloperoxidase, imunoistoquímicas para iNOS e dosagem de malonaldeído, e citocinas (TNF-α, IL-1β, IL-10). Os dados paramétricos foram analisados por ANOVA/teste de Tukey ou teste T e os dados não paramétricos por Kruskal-Wallis/teste de Dunn. Houve aumento do peso úmido dos cólons no grupo TNBS e prevenção desse evento no grupo EAC. Os grupos TNBS e EAC apresentaram aumento na infiltração de neutrófilos no cólon em relação aos demais grupos. O grupo TNBS apresentou aumento na pontuação dos escores microscópicos em relação aos grupos tratados. Os grupos TNBS e EAC apresentaram aumento na concentração de IL-1β no cólon. O grupo TNBS apresentou supressão na concentração de IL-10 no cólon, prevenido pelo tratamento com EAC. O grupo EAC apresentou diminuição na concentração de MDA no cólon em relação ao grupo TNBS. O grupo EAC apresentou diminuição na expressão de iNOS no conjuntivo em relação ao grupo TNBS. O grupo TNBS não apresentou alteração da hipernocicepção, avaliada pelo Von Frey, nos tempos 24 e 72 horas. Conclui-se que eletroacupuntura, a 100Hz no acuponto ST-36, apresentou ação antiinflamatória na colite por TNBS em etanol a 50% através do aumento na concentração de IL-10 e redução na expressão de iNOS.
43
RIMETZ, FREDERIC. "La colite a eosinophiles : a propos d'une observation." Lille 2, 1992. http://www.theses.fr/1992LIL2M111.
Full text
44
NOTTEGHEM, BERTRAND. "Que deviennent les colites aigues inclassees ? resultats d'une etude de cohorte de 104 malades dans la region nord pas-de-calais." Lille 2, 1994. http://www.theses.fr/1994LIL2M068.
Full text
45
Léger-Cresson, Nathalie. "Introduction d'une Légumineuse fourragère, (Mucuna aterrima Holl. ), dans la culture du mai͏̈s pluvial à Colima (Mexique)." Montpellier 2, 1989. http://www.theses.fr/1989MON20168.
Full text
46
Yáñez, C. César. "Propuesta para el mejoramiento de la gestión municipal del manejo de sólidos domiciliarios de la Comuna de Colina, Región Metropolitana." Tesis, Universidad de Chile, 2005. http://www.repositorio.uchile.cl/handle/2250/105085.
Full text
47
Garcés, O. Matías. "El Patrimonio Cultural en las Canteras de Colina:Una Reflexión Social en Torno a su Preservación." Tesis, Universidad de Chile, 2008. http://www.repositorio.uchile.cl/handle/2250/106659.
Full text
48
BREARD, VIANNEY. "La crise de colique nephretique : elements epidemiologiques, evolutifs et meteorologiques." Nantes, 1991. http://www.theses.fr/1991NANT130M.
Full text
49
DAVION, COEVOET MARTINE. "Polypose gastrique hyperplasique et adenomes coliques familiaux : a propos d'un cas." Lille 2, 1993. http://www.theses.fr/1993LIL2M262.
Full text
50
Jiménez, Velázquez María del Carmen Gardenia. "Caracterización geomorfológica del Volcán de Fuego de Colima." Tesis de Licenciatura, Universidad Autónoma del Estado de México, 2018. http://hdl.handle.net/20.500.11799/95410.
Full textAbstract:
El Volcán de Fuego de Colima está localizado al Norte del estado de Colima, en los límites con el estado de Jalisco, es un complejo volcánico que pertenece al eje volcánico trasversal mexicano. Se ha caracterizado por ser uno de los volcanes más activos del país, es por ello que debido a la constante actividad, el edificio volcánico muestra una morfología específica, misma que se analizó mediante métodos geográficos como el reconocimiento de sitio de estudio y la elaboración e interpretación de cartografía morfológica y morfométrica que permitió conocer el comportamiento de relieve en dicha zona.
Los resultados obtenidos con el análisis geomorfológico del sitio de estudio, se determinó que debido a la constante actividad volcánica del complejo, la morfología del lugar está en constante cambio debido a la expulsión de material incandescente y arrastre fluvial debido a las laderas con pendiente pronunciada, muestra una importante demarcación hecha por el material piroclástico que ha ido erosionando el cono.