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Relevant bibliographies by topics / Coumarin scavenging

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Journal articles

Academic literature on the topic 'Coumarin scavenging'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Coumarin scavenging"

1

Prahadeesh, N., Maheswaran Sithambaresan, and Umaramani Mathiventhan. "A Study on Hydrogen Peroxide Scavenging Activity and Ferric Reducing Ability of Simple Coumarins." Emerging Science Journal 2, no. 6 (2018): 417. http://dx.doi.org/10.28991/esj-2018-01161.

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Coumarin compounds are δ-lactones where α-pyrone ring is fused with benzene ring. Coumarins are widely distributed in the plant kingdom as well as they are very important in synthetic organic chemistry. Coumarins have great interest because of their abundance in nature and diverse pharmacological activities including antibacterial, antiviral, antipyretic, and anticoagulant, antioxidant, anti-inflammatory and anticancer. This study focused on synthesizing different simple Coumarins and studying their antioxidant activity. Four simple Coumarins (Coumarin (C1), 4-hydroxy coumarin (C2), 7-hydroxy

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2

Razo-Hernández, Rodrigo, Kayim Pineda-Urbina, Marlene Velazco-Medel, et al. "QSAR study of the DPPH· radical scavenging activity of coumarin derivatives and xanthine oxidase inhibition by molecular docking." Open Chemistry 12, no. 10 (2014): 1067–80. http://dx.doi.org/10.2478/s11532-014-0555-x.

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AbstractA Quantitative Structure-Activity Relationship (QSAR) of coumarins by genetic algorithms employing physicochemical, topological, lipophilic and electronic descriptors was performed. We have used experimental antioxidant activities of specific coumarin derivatives against the DPPH· radical molecule. Molecular descriptors such as Randic Path/Walk, hydrophilic factor and chemical hardness were selected to propose a mathematical model. We obtained a linear correlation with R2 = 96.65 and Q LOO2 = 93.14 values. The evaluation of the predictive ability of the model was performed by applying

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3

Šeršeň, F., and M. Lácová. "Antioxidant activity of some coumarins / Antioxidačná activita niektorých kumarínov." Acta Facultatis Pharmaceuticae Universitatis Comenianae 62, s9 (2015): 41–45. http://dx.doi.org/10.1515/afpuc-2015-0011.

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AbstractNineteen derivatives of coumarin were tested on the scavenging of 2,2-diphenyl-1-picrylhydrazyl, hydroxyl and superoxide anion radicals. It was found that antioxidant activity exhibits only such coumarins that contain hydroxyl groups. The derivatives without hydroxyl group showed very low antioxidant effectiveness or they were ineffective. On the other hand, the greatest antioxidant effectiveness was exhibited by coumarin derivatives that contained hydroxyl groups in 6 or 8 position, whereas the effectiveness of derivatives with one hydroxyl group in 4, 5 or 7 position was very low. Ba

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4

Abul Qais, Faizan, and Iqbal Ahmad. "Mechanism of non-enzymatic antiglycation action by coumarin: a biophysical study." New Journal of Chemistry 43, no. 32 (2019): 12823–35. http://dx.doi.org/10.1039/c9nj01490j.

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5

Singh, Parvesh, Nomandla Ngcoya, Ramgopal Mopuri та ін. "α-Glucosidase Inhibition, Antioxidant and Docking Studies of Hydroxycoumarins and their Mono and Bis O-alkylated/acetylated Analogs". Letters in Drug Design & Discovery 15, № 2 (2018): 127–35. http://dx.doi.org/10.2174/1570180814666170602081941.

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Background: Diabetes Mellitus (DM) is a complex metabolic disease illustrated by abnormally high levels of plasma glucose or hyperglycaemia. Accordingly, several α-glucosidase inhibitors have been developed for the treatment of diabetes and other degenerative disorders. While, a coumarin ring has the privilege to represent numerous natural and synthetic compounds with a wide spectrum of biological activities e.g. anti-cancer, anti-HIV, anti-viral, anti-malarial, anti-microbial, anti-convulsant, anti-hypertensive properties. Besides this, coumarins have also shown potential to inhibit α-glucosi

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6

Amić, Ana, and Elena Gotal. "Selected Thermodynamic Parameters of Antioxidant Activity of Coumarin Based Heterocyclic Compounds." Chemistry Proceedings 3, no. 1 (2020): 109. http://dx.doi.org/10.3390/ecsoc-24-08385.

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Coumarin and coumarin derivatives are bioactive compounds that have an important role in medicinal chemistry, for example in the development of anti-inflammatory, anticancer and antiviral drugs. These compounds are also very powerful antioxidants that successfully scavenge free radicals and prevent or alleviate oxidative stress. The antioxidant potential of selected heterocyclic compounds containing coumarin core was investigated theoretically, the focus of this study was on hydrogen atom transfer mechanism (HAT) and single electron transfer followed by a proton transfer mechanism (SET-PT). Us

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7

Bistrović, A., N. Stipaničev, T. Opačak-Bernardi, et al. "Synthesis of 4-aryl-1,2,3-triazolyl appended natural coumarin-related compounds with antiproliferative and radical scavenging activities and intracellular ROS production modification." New Journal of Chemistry 41, no. 15 (2017): 7531–43. http://dx.doi.org/10.1039/c7nj01469d.

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Diverse natural coumarin-based compounds linked to aryl via a 1,2,3-triazole spacer with antiproliferative activity against K562 cells, radical scavenging activity and a decrease of ROS production were provided.

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8

Drábiková, Katarína, Tomáš Perečko, Radomír Nosál’, Juraj Harmatha, Jan Šmidrkal, and Viera Jančinová. "Study of Possible Mechanisms Involved in the Inhibitory Effects of Coumarin Derivatives on Neutrophil Activity." Oxidative Medicine and Cellular Longevity 2013 (2013): 1–10. http://dx.doi.org/10.1155/2013/136570.

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To specify the site of action of the synthetic coumarin derivatives 7-hydroxy-3-(4′-hydroxyphenyl) coumarin (HHC) and 7-hydroxy-3-(4′-hydroxyphenyl) dihydrocoumarin (HHDC), we evaluated their effects on extra- and intracellular reactive oxygen species (ROS) formation in phorbol-myristate-13-acetate (PMA) stimulated human neutrophils. We studied also the effects of HHC and HHDC on possible molecular mechanisms which participate in the activation of NADPH oxidase, that is, on PKC activity, on phosphorylation of some PKC isoforms (α,βII, andδ), and on phosphorylation of the NADPH oxidase subunit

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9

Salar, Uzma, Khalid M. Khan, Sridevi Chigurupati та ін. "New Hybrid Scaffolds based on Hydrazinyl Thiazole Substituted Coumarin; As Novel Leads of Dual Potential; In Vitro α-Amylase Inhibitory and Antioxidant (DPPH and ABTS Radical Scavenging) Activities". Medicinal Chemistry 15, № 1 (2019): 87–101. http://dx.doi.org/10.2174/1573406414666180903162243.

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Background: Despite many side effects associated, there are many drugs which are being clinically used for the treatment of type-II diabetes mellitus (DM). In this scenario, there is still need to develop new therapeutic agents with more efficacy and less side effects. By keeping in mind the diverse spectrum of biological potential associated with coumarin and thiazole, a hybrid class based on these two heterocycles was synthesized. Method: Hydrazinyl thiazole substituted coumarins 4-20 were synthesized via two step reaction. First step was the acid catalyzed reaction of 3-formyl/acetyl coumar

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10

Dao, Phan Thi Anh, Tran Le Quan, and Nguyen Thi Thanh Mai. "Constituents of the Stem of Nauclea orientalis." Natural Product Communications 10, no. 11 (2015): 1934578X1501001. http://dx.doi.org/10.1177/1934578x1501001122.

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A new α-pinene derivative (1) was isolated from the stem of Nauclea orientalis (L.) L. (Rubiaceae), together with twelve known compounds, including four terpenoids, loganetin (2), loganin (3), sweroside (4), grandifloroside (5), four simple phenols, methyl protocatechuate (6), trans- p-coumaric acid (7), 3-(2,4-dihydroxylphenyl)propanoic acid (8), methyl 3-(2,4-dihydroxylphenyl)propanoate (9), two coumarin glucosides, skimmin (10), adicardin (11), an anthraquinone, aloe emodin (12), and a lignan, (+)-pinoresinol (13). Their structures were elucidated on the basis of spectroscopic data. All com

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