Relevant bibliographies by topics / Coupling reagent

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  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Coupling reagent'

Author: Grafiati
Published: 4 June 2021
Last updated: 18 February 2022

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Journal articles on the topic "Coupling reagent"

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Hu, Long, and Junfeng Zhao. "Ynamide: A New Coupling Reagent for Amide and Peptide Synthesis." Synlett 28, no. 14 (2017): 1663–70. http://dx.doi.org/10.1055/s-0036-1588860.

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The discovery and application of ynamide coupling reagents is highlighted with a brief summary of the development history of coupling reagents in amide and peptide synthesis. As novel coupling reagents, ynamides are not only effective for simple amide and dipeptide synthesis but also can be used for peptide fragment condensation. More importantly, no racemization was detected during the activation of α-chiral carboxylic acids by employing ynamide coupling reagents.1 Introduction2 Carbodiimide Coupling Reagents3 Uronium/Guanidinium Salt Coupling Reagents4 Phosphonium Salt Coupling Reagents5 Ethoxyacetylene as a Coupling Reagent6 Ynamine Coupling Reagents7 Ynamide Coupling Reagents8 Summary and Outlook
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Krylov, Igor B., Vera A. Vil’, and Alexander O. Terent’ev. "Cross-dehydrogenative coupling for the intermolecular C–O bond formation." Beilstein Journal of Organic Chemistry 11 (January 20, 2015): 92–146. http://dx.doi.org/10.3762/bjoc.11.13.

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The present review summarizes primary publications on the cross-dehydrogenative C–O coupling, with special emphasis on the studies published after 2000. The starting compound, which donates a carbon atom for the formation of a new C–O bond, is called the CH-reagent or the C-reagent, and the compound, an oxygen atom of which is involved in the new bond, is called the OH-reagent or the O-reagent. Alcohols and carboxylic acids are most commonly used as O-reagents; hydroxylamine derivatives, hydroperoxides, and sulfonic acids are employed less often. The cross-dehydrogenative C–O coupling reactions are carried out using different C-reagents, such as compounds containing directing functional groups (amide, heteroaromatic, oxime, and so on) and compounds with activated C–H bonds (aldehydes, alcohols, ketones, ethers, amines, amides, compounds containing the benzyl, allyl, or propargyl moiety). An analysis of the published data showed that the principles at the basis of a particular cross-dehydrogenative C–O coupling reaction are dictated mainly by the nature of the C-reagent. Hence, in the present review the data are classified according to the structures of C-reagents, and, in the second place, according to the type of oxidative systems. Besides the typical cross-dehydrogenative coupling reactions of CH- and OH-reagents, closely related C–H activation processes involving intermolecular C–O bond formation are discussed: acyloxylation reactions with ArI(O2CR)2 reagents and generation of O-reagents in situ from C-reagents (methylarenes, aldehydes, etc.).
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El-Faham, Ayman, Fernando Albericio, Srinivasa Rao Manne, and Beatriz G. de la Torre. "OxymaPure Coupling Reagents: Beyond Solid-Phase Peptide Synthesis." Synthesis 52, no. 21 (2020): 3189–210. http://dx.doi.org/10.1055/s-0040-1706296.

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AbstractOxymaPure [ethyl 2-cyano-2-(hydroxyimino)acetate] is an exceptional reagent with which to suppress racemization and enhance coupling efficiency during amide bond formation. The tremendous popularity of OxymaPure has led to the development of several Oxyma-based reagents. OxymaPure and its derived reagents are widely used in solid- and solution-phase peptide chemistry. This review summarizes the recent developments and applications of OxymaPure and Oxyma-based reagents in peptide chemistry, in particular in solution-phase chemistry. Moreover, the side reaction associated with OxymaPure is also discussed.1 Introduction2 Oxyma-Based Coupling Reagents2.1 Aminium/Uronium Salts of OxymaPure2.2 Phosphonium Salts of OxymaPure2.3 Oxyma-Based Phosphates2.4 Sulfonate Esters of OxymaPure2.5 Benzoate Esters of OxymaPure2.6 Carbonates of OxymaPure Derivatives3 OxymaPure Derivatives4 Other Oxime-Based Additives and Coupling Reagents5 Side Reactions Using OxymaPure Derivatives6 Conclusion7 List of Abbreviations
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Dong, Zhi-Bing, and Jin-Quan Chen. "Recent Progress in Utilization of Functionalized Organometallic Reagents in Cross Coupling Reactions and Nucleophilic Additions." Synthesis 52, no. 24 (2020): 3714–34. http://dx.doi.org/10.1055/s-0040-1706550.

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AbstractOrganometallic compounds have become increasingly important in organic synthesis because of their high chemoselectivity and excellent reactivity. Recently, a variety of organometallic reagents were found to facilitate transition-metal-catalyzed cross-coupling reactions and nucleophilic addition reactions. Here, we have summarized the latest progress in cross-coupling reactions and in nucleophilic addition reactions with functionalized organometallic reagents present to illustrate their application value. Due to the tremendous contribution made by the Knochel group towards the development of novel organometallic reagents, this review draws extensively from their work in this area in recent years.Introduction1 Transition-Metal-Catalyzed Cross Couplings Involving Organo­zinc Reagents2 Transition-Metal-Catalyzed Cross Couplings Involving Organomagnesium Reagents3 Transition-Metal-Free Cross Couplings Involving Zn and Mg ­Organometallic Reagents4 Nucleophilic Additions Involving Zn and Mg Organometallic Reagents5 Cross-Coupling Reactions or Nucleophilic Additions Involving Mn, Al-, La-, Li-, Sm- and In-Organometallics6 Conclusion
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Jordan, Andrew, and Helen F. Sneddon. "Development of a solvent-reagent selection guide for the formation of thioesters." Green Chemistry 21, no. 8 (2019): 1900–1906. http://dx.doi.org/10.1039/c9gc00355j.

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Campos de Carvalho, A., F. Ramon, and D. C. Spray. "Effects of protein reagents on electrotonic coupling in crayfish septate axon." American Journal of Physiology-Cell Physiology 251, no. 1 (1986): C99—C103. http://dx.doi.org/10.1152/ajpcell.1986.251.1.c99.

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The lateral giant axons of the crayfish nerve cord are composed of segments contributed by each ganglion, which are electrotonically coupled by way of gap junctions. We have investigated the involvement of protein residues in regulating the resistance of crayfish junctional channels by determining effects of group-specific protein reagents. When applied to well-coupled axons, the sulfhydryl group reagents N-ethylmaleimide (NEM) and diamide uncoupled the segments; junctional resistance (Rj) was increased without changing membrane resistance or axoplasmic pH (pHi). The uncoupling produced by NEM could be reversed by alkalinization of the cytoplasm (addition of ammonium chloride to the external medium). Another sulfhydryl reagent (p-chloromercuribenzoic acid) increased Rj to a lesser extent. A disulfide reagent and three amino and three carboxyl group reagents had no effect on the Rj of these axons. The effect of group-specific reagents on partially uncoupled axons was tested by applying the drugs to axons previously exposed to weak acids. N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline recoupled partially uncoupled axons by decreasing Rj and prevented subsequent uncoupling of the junction by low pHi. Another carboxyl group reagent, as well as sulfhydryl and amino group reagents, either had no effect or uncoupled the axons further by increasing Rj. These experimental results suggest that amino acid residues, possibly containing carboxyl and sulfhydryl groups, control the opening and closing of junctional channels and may thus be associated with the channels' active sites.
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Miralles, N., R. M. Romero, E. Fernández, and K. Muñiz. "A mild carbon–boron bond formation from diaryliodonium salts." Chemical Communications 51, no. 74 (2015): 14068–71. http://dx.doi.org/10.1039/c5cc04944j.

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Metal-free borylation of diaryliodonium salts with diboron reagents toward formation of aryl boronic esters and concomitant two-step C–C coupling of both aryl groups of the initial diaryliodonium reagent.
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Yorimitsu, Hideki, and Koichiro Oshima. "New synthetic reactions catalyzed by cobalt complexes." Pure and Applied Chemistry 78, no. 2 (2006): 441–49. http://dx.doi.org/10.1351/pac200678020441.

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Without suffering from β-elimination, cobalt complexes allow cross-coupling reactions of alkyl halides with Grignard reagents. A combination of a cobalt complex and trimethylsilylmethyl Grignard reagent effects Mizoroki-Heck-type reaction of alkyl halide with styrene, which conventional palladium catalysts have never made possible. Cobalt exhibits intriguing catalytic activities on hydrophosphination and allylzincation of alkynes. Silylmethylcobalt reagent is a powerful tool for the synthesis of highly silylated ethenes.
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Jiang, Chao, Xiangbing Qi, and Chao Yang. "Alkylzirconocenes in Organic Synthesis: An Overview." Synthesis 53, no. 06 (2021): 1061–76. http://dx.doi.org/10.1055/s-0040-1706146.

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AbstractOrganozirconium chemistry has found extensive applications in organic synthesis since its discovery in the last century. Alkyl­zirconocenes, which are easily generated by the hydrozirconation of alkenes with the Schwartz reagent, are widely utilized for carbon–carbon­ and carbon–heteroatom bond formation. This short review summarizes the progress to date on the applications alkylzirconocenes in organic synthesis.1 Introduction2 General Methods for Generating Alkylzirconocenes3 Transformations of Alkylzirconocenes by Heteroatoms4 Insertion of Unsaturated Groups into Alkylzirconocenes5 Transmetalations6 Cross-Coupling Reactions of Alkylzirconocenes7 Photochemistry of Alkylzirconocenes8 Bimetallic Reagents of Zirconium9 Asymmetric Transformations10 Applications of Alkylzirconocenes Generated from the Negishi Reagent11 Conclusions and Outlook
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Soural, Miroslav, and Veronika Ručilová. "Recent Advances in the Applications of Triethylsilane in Organic Synthesis." Synthesis 50, no. 19 (2018): 3809–24. http://dx.doi.org/10.1055/s-0037-1610107.

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The synthesis of pharmacologically relevant scaffolds is an important goal in modern organic chemistry. For this reason, the use of methodologies involving operationally simple procedures and easily handled reagents to chemoselectively and stereoselectively convert different functionalities has gained considerable attention. In this review, we summarize the latest trends in reductive reactions using triethyl­silane as the key reagent that provide synthetically interesting intermediates, coupling products and structures with control of the 3D architecture.1 Introduction2 Scenario A: Reduction of C–C Multiple Bonds3 Scenario B: Reduction of Functional Groups4 Scenario C: Reductive Coupling5 Scenario D: Reductive Cyclization6 Conclusion
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Dissertations / Theses on the topic "Coupling reagent"

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Pozza, Giorgio, A. Cattazzo, S. Mammi, and T. Carofiglio. "Investigation of the Reaction Mechanism between Bovine Collagen and a Triazine- Based Coupling Reagent - 253." Verein für Gerberei-Chemie und -Technik e. V, 2019. https://slub.qucosa.de/id/qucosa%3A34201.

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Content: The triazine-based coupling reagent 4-(4,6-dimethoxy-1,3,5-triazin-2-yl)-4-methylmorpholinium chloride (DMTMM) is a promptly water-soluble white solid commonly used in chemical synthesis, which is proven to act as effective tanning agent. This research work provides an experimental evidence that the tanning ability of DMTMM is associated to an increase of the cross-linking density in the collagen molecule. As a result of the coupling reaction, DMTMM is converted into water-soluble by-products that can be removed by washing. Take-Away: chrome free tanning, reaction mechanism
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Robinson, Matthew Peter. "Ortho-substituted arylsilanes in oxidative gold catalysis." Thesis, University of Edinburgh, 2018. http://hdl.handle.net/1842/31394.

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Organometallic compounds derived from tin, boron, and zinc, have been used extensively in transition metal-catalysed cross-coupling, and continue to hold status as the go-to reagents to form new carbon-carbon bonds. Recently, organosilicon compounds have emerged as an attractive alternative to these established reagents, benefitting from low toxicity, low cost, and general ease of handling. While the fundamental reactivity of arylsilane reagents (Ar-SiR3) is well known, their role in transition metal-catalysed reactions is generally less well studied. This thesis comprises an investigation into the effect of ortho-substitution of these arylsilane reagents, and specifically, their application in gold-catalysed direct arylation. In Chapter 2, the transmetalation of these reagents to gold(III) is assessed using a combination of in situ reaction monitoring coupled with kinetic simulations. This allowed a scale of reactivity to be constructed for a range of structurally diverse arylsilanes, and uncovered that more sterically hindered arylsilanes actually exhibit accelerated rates of transmetalation. In Chapter 3, the reactivity of ortho-substituted arylsilanes in gold-catalysed arylation is addressed. The majority of arylsilanes tested in the previous chapter were found to be unable to undergo coupling, despite the viability of transmetalation having been demonstrated. Slight modification of the ortho-substituent, to incorporate a tethered ligand, was found to have a dramatic effect on reactivity, and allowed the coupling of a variety of substrates. The nature of the ligand, as well as the substitution of the tether was found to have a significant impact on the rate of coupling. Chapter 4 describes the way in which the reactivity of ortho-substituted arylsilanes might be exploited in a 'Catch and Release' protocol for catalyst recovery. This aims to combine the established benefits of homogeneous and heterogeneous catalysis to offer an alternative to current methods of catalyst recycling in industrial chemistry. A number of different 'Catch and Release' mechanisms were considered, and the validity of the concept was demonstrated in a monophasic system.
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Haraguchi, Ryosuke. "Studies on Preparation of Functionalized Organozinc Reagents via Zinciomethylation." 京都大学 (Kyoto University), 2016. http://hdl.handle.net/2433/215552.

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Begouin, Jeanne-Marie. "Activation de composés aromatiques et hétéroaromatiques pour la formation de liaisons C-C et C-N par catalyse au cobalt." Thesis, Paris Est, 2009. http://www.theses.fr/2009PEST0033.

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Les réactions de couplage croisé catalysées par des métaux de transition permettant la formation de liaisons C-C et C-hétéroatome sont à la base de la synthèse d’intermédiaires clefs pour la chimie pharmaceutique, la chimie supramoléculaire et la chimie des matériaux. Cependant, certains catalyseurs métalliques utilisés sont reconnus comme étant assez coûteux ou toxiques. Le développement de catalyseurs alternatifs peu coûteux et écologiques, tels que les catalyseurs à base de cobalt qui ont déjà montré leur efficacité pour la formation de liaisons C-C, fait donc l’objet d’études. Nous avons décidé d’utiliser des organozinciques aromatiques fonctionnalisés, obtenus facilement à l’aide d'une réaction catalysée par CoBr2, dans des réactions de couplage catalysées par CoBr2 avec des chloro-diazines et -triazines aboutissant à la synthèse d’aryldiazines et -triazines. Des organozinciques benzyliques ont également pu être utilisés dans ces réactions permettant la synthèse de benzyltriazines. Nous avons également envisagé l’utilisation d’autres types de substrats. Des réactions de couplage catalysées par CoBr2 entre des organozinciques aromatiques et des méthylthiopyrimidines ou le 2- méthylthiobenzo[b]thiazole ont ainsi été réalisées, conduisant à la synthèse de 2,4- diarylpyrimidines ou de 2-arylbenzo[b]thiazoles. Nous avons également étudié la réactivité des dérivés du benzonitrile dans les couplages directs catalysés par CoBr2 avec des halogénures aromatiques basés sur l’activation de la liaison C-CN pour former des biaryles. Enfin, des réactions de couplage croisé C-N entre des halogénures aromatiques et l’aniline conduisant à la synthèse de diarylamines ont été étudiées<br>Transition metal-catalyzed cross-coupling reactions allowing the formation of C-C or C-Heteroatom bonds underlie the synthesis of key intermediates for pharmaceutical, supramolecular chemistry and material sciences. Thereby, the development of these methodologies is prominent and an increasing number of studies are devoted to these processes. However, some metallic catalysts are known to be rather expensive or toxic. Consequently, the development of alternative sustainable catalysts such as cobalt or ironbased catalysts has been studied over the past few years. Cobalt-catalysts have been little-used although they have shown to be effective for various C-C bond forming reactions. Functionalized arylzinc reagents can be readily obtained from the corresponding arylhalides using a CoBr2-catalyzed reaction. First we envisioned using these arylzinc reagents in CoBr2-catalyzed cross-coupling reactions with chlorodiazines and chlorotriazines leading to aryldiazines and aryltriazines. Benzylzinc reagents had also been used in these reactions and we synthesized various benzyltriazines in this manner. We also studied whether we can use other kind of substrates in these reactions. Thus, we performed CoBr2-catalyzed cross-coupling reactions between arylzinc reagents and methylthiopyrimidines or methylthiobenzo[b]thiazole derivatives leading to 2,4-diarylpyrimidines and 2- arylbenzo[b]thiazole. Then, we studied the reactivity of benzonitrile derivatives in direct cross-coupling reactions with arylhalide based on C-CN bond activation using CoBr2 as catalyst. Finally, we also carried out the study of CoBr2-catalyzed C-N cross-coupling reactions for the synthesis of diarylamines
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Findik, Hamide. "Potassium Permanganate/ Carboxylic Acid/ Organic Solvent: A Powerful Reagent For C-c Bond Formation, Aryl Coupling Reactions And Enone Oxidation Ipso-nitration Of Arylboronic Acids With Silver Nitrite/ Tmscl." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/12610472/index.pdf.

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The first part of the thesis presents the KMnO4/ carboxylic acid/ organic solvent which is a powerful reagent for C-C bond formation, aryl coupling reactions and enone oxidation. The a&cent<br>-acetoxylation of enones and the a-acetoxylation of aromatic ketones were carried out with potassium permanganate and acetic acid, in which acetoxylation products were obtained in 74-96% yields. The same reaction was carried out with carboxylic acids other than acetic acid, which furnished corresponding acyloxy ketones with the same regioselectivity. For the first time, formyloxylation products were synthesized in a 61-85% yield by using formic acid. The potassium permanganate and acetic acid method was also used for aryl coupling reactions. The reaction of arylboronic acids and aryl hydrazines in benzene with potassium permanganate and acetic acid in turn furnished biaryls in a 85-96% yield. We showed that potassium permanganate/carboxylic acid/organic solvent behaves as manganese(III) acetate. In the second part of the thesis, ipso-nitration of arylboronic acids with AgNO2/ TMSCl was performed. Nitration of aromatic compounds is one of the most extensively studied reactions, and nitroaryl moieties play key roles in the physical and chemical properties of many target molecules in organic synthesis. For electrophilic nitration of aromatic compounds, a wide variety of reagents are available to date. Most of them are very strong nitrating agents and often lead to further nitration and mixture of isomers. Since most nitrating agents are oxidants, oxidation of other functional groups can also occur, giving a mixture of products. Thus, a search for milder and selective nitrating agents is a good research goal. In this work, we aimed to apply AgNO2/ TMSCl system to ipso nitration of arylboronic acids.
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Pearson, Mark. "Organometallic reagents for catalytic cross-coupling." Thesis, University of Oxford, 1992. http://ora.ox.ac.uk/objects/uuid:c5eea9a0-8f0c-46bf-a1ea-28a40b79546d.

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Phosphine complexes of nickel and palladium provide the best catalysts for the homogeneous catalysed carbon-carbon bond forming reaction between an organometallic nucleophile and an organic electrophile. Use of a homochiral ligand on the catalyst can lead to stereoselectivity in the cross-coupling reaction, with high ee's of coupled product being obtained. The processes of selectivity in the transmetalation step of the catalytic cycle have not been elucidated and the initial aim of the project was to study these processes. Initial experiments using organotin derivatives as the organometallic nucleophile highlighted the problems of selectivity and the forcing conditions needed in the attempted transfer of a benzyl group from the tin to the palladium catalyst. The compounds [8- (dimethylamino)-1-naphthyl]methyldiphenyltin (60) and [2-((dimethylamino)methyl) phenyl]methyldiphenyltin (70) were prepared and their reactivity in the palladium catalysed cross-coupling with 2-furoyl chloride, to give 2-benzoylfuran, was investigated. These molecules were found to undergo facilitated transfer of a phenyl group compared to transfer from control molecules. The effect was tested and attributed to the internal nucleophilic attack at the tin atom by the lone pair on the nitrogen atom. The compound [2- ((dimethylamino)methyl)-3-trimethylsilylphenyl]methyldiphenyltin (79) was prepared to test the effects of steric buttressing within the molecule, but was found to be of the same order of magnitude of reactivity as (60) and (70). All three molecules showed a reactivity of at least an order of magnitude greater than control compounds. The effect did not prove applicable to the transfer of a benzyl group or in other coupling reactions. The effect of palladium ligation was tested and the ligand triphenyl arsine found to increase the rate of the coupling reaction. The two facilitating processes were found to work in a co-operative fashion, giving a rate enhancement of ca. one hundredfold over control reactions. The nickel catalysed cross-coupling of α-substituted sp<sup>3</sup> hybridised Grignard reagents with allylic esters was attempted, but proved unsuccessful. Stoichiometric reactions with nickel complexes were also found to be unsatisfactory in yielding coupled products. The synthesis of α-substituted diorganozinc reagents was attempted, but furnished only homocoupled products. The reaction of dibenzylzinc with aldehydes was found to proceed in the absence of catalyst, highlighting the reactivity of a benzylzinc moiety.
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Woods, Tom MacDonald. "Phosphinates as new electrophilic reagents for cross-coupling reactions." Thesis, Durham University, 2008. http://etheses.dur.ac.uk/2130/.

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Activated esters, e.g. triflates, sulfonates, nonaflates and phosphates are excellent electrophiles for a variety of cross-coupling reactions. However, other phosphorus-based esters have received little attention in these protocols. This thesis discusses the synthesis and cross-coupling chemistry of vinyl phosphinates, a new class of electrophilic species. A simple model vinyl phosphinate, N-(tert-butyloxycarbonyl)-4,5,6,7-tetrahydro-1H-azepin-2-yl-diphenylphosphinate, was prepared in excellent yield from commercially available caprolactam. A screening study identified Suzuki cross-coupling conditions under which this phosphinate smoothly coupled with a variety of electron-rich, electron-poor and sterically-hindered boronic acids. The scope and limitations of this chemistry were investigated and a variety of electron-withdrawing nitrogen protecting groups, e.g. Boc, CO(_2)Ph, C0(_2)Bn and Ts could be used without problem. However, electron-donating protecting groups, e.g. Me and Bn proved unsuccessful. Additionally, where seven and eight-membered ring lactam phosphinates coupled efficiently, five and six-membered ring derivatives proved largely unsuccessful. Relative reactivity studies were carried out with N-phenyloxycarbonyl-2- (diphenylphosphinoyloxy)-3,4-dihydro-6-bromoquinolone and indicated that the reactivity of vinyl phosphinates lies between that of aryl chlorides and aryl bromides in the Suzuki reaction. Attempts to improve the efficiency of the cross-coupling of this substrate using DoE and PCA modelling was attempted, but was largely unsuccessful. Studies towards the total synthesis of Lennoxamine via a cross-coupling reaction between a benzazepine-derived vinyl phosphinate and 2,3-dimethoxy-N-(2'-phenylpropan-2-yl)-6-(tributylstannyl) benzamide were commenced. Synthesis of the stannane was achieved in high yield via a directed metallation strategy. Unfortunately, preliminary attempts to cross-couple this stannane with N-(benzyloxycarbonyl)-4,5,6,7- tetrahydro-1 H-azepin-2-yl diphenylphosphinate in a model reaction were unsuccessful. Synthesis of the desired benzazepine phosphinate fragment proved more difficult and although progress has been made, this work remains unfinished. Additionally, treatment of N-([4'-methylphenyl]sulfonyl)-2-oxo-azepane with LDA/TMEDA in the presence of diphenylphosphoryl chloride afforded the sultam 1,2,3,4-tetrahydro-7-methylazepino[1,2-b][1,2]benzothiazole-10,10-dioxide in moderate yield. A range of aryl sulfonamides could be used affording the corresponding sultams in moderate yields.
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Schuster, Christopher Henry. "Synthesis and Utility of Organoboron Reagents for Enantioselective Synthesis." Thesis, Boston College, 2014. http://hdl.handle.net/2345/bc-ir:103558.

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Thesis advisor: James P. Morken<br>Described herein are three distinct projects centered on the formation and use of carbon-boron bonds. In the first, the enantioselective platinum-catalyzed 1,4-diboration of trans-1,3-dienes is advanced in both selectivity and scope through the development of a novel class of electron rich chiral monodentate phosphines. Under the action of the new ligands, highly selective diboration is maintained at reduced loadings of catalyst. Secondly, enantioenriched 1,2-bis(pinacol boronates) are engaged in regioselective Suzuki-Miyaura cross-coupling with aryl and vinyl electrophiles. A tandem diboration cross-coupling sequence is successfully implemented to afford homobenzylic and homoallylic pinacol boronates directly from terminal olefins, which subsequently undergo oxidation, amination or homologation of the remaining carbon-boron bond to arrive at a range of enantioenriched products. Lastly, aryl electrophiles containing tethered allylboronate units undergo efficient intramolecular coupling in the presence of a chiral palladium catalyst to give enantioenriched carbocyclic products<br>Thesis (PhD) — Boston College, 2014<br>Submitted to: Boston College. Graduate School of Arts and Sciences<br>Discipline: Chemistry
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Jensen, Anne Eeg. "Transition metal-catalyzed cross-coupling reactions of functionalized organometallic reagents." Diss., lmu, 2001. http://nbn-resolving.de/urn:nbn:de:bvb:19-2331.

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Sore, Hannah Fiona. "The synthesis and palladium catalysed cross coupling of organosilicon reagents." Thesis, University of Cambridge, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.608633.

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Books on the topic "Coupling reagent"

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Dohi, Toshifumi, Jian-Wei Han, and Ravi Kumar, eds. New Hypervalent Iodine Reagents for Oxidative Coupling. Frontiers Media SA, 2021. http://dx.doi.org/10.3389/978-2-88966-650-8.

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Molander, Gary A. Catalyst Components for Coupling Reactions. Wiley & Sons, Incorporated, John, 2013.

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Molander, Gary A. Catalyst Components for Coupling Reactions. Wiley & Sons, Incorporated, John, 2013.

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Book chapters on the topic "Coupling reagent"

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Li, Jie Jack. "Yamada coupling reagent." In Name Reactions. Springer Berlin Heidelberg, 2002. http://dx.doi.org/10.1007/978-3-662-04835-1_312.

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Li, Jie Jack. "Yamada coupling reagent." In Name Reactions. Springer Berlin Heidelberg, 2003. http://dx.doi.org/10.1007/978-3-662-05336-2_327.

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Roux, F., J. Coste, E. Frérot, D. Le-Nguyen, P. Jouin, and A. Loffet. "TPyClU: A new peptide coupling reagent." In Peptides. Springer Netherlands, 1992. http://dx.doi.org/10.1007/978-94-011-2264-1_249.

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Horiki, Kusuo. "An efficient phosphorus-based peptide coupling reagent." In Peptide Chemistry 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1474-5_13.

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Thern, Bernd, Joachim Rudolph, and Günther Jung. "Triphosgene as Peptide Coupling Reagent: Highly Efficient Total Synthesis of Cyclosporin O." In Peptides: The Wave of the Future. Springer Netherlands, 2001. http://dx.doi.org/10.1007/978-94-010-0464-0_110.

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Pipkorn, R., M. Beyermann, and P. Henklein. "2-(2-oxo-1(2H)-pyridyl)-1,1,3,3-bispentamethylene uroniumtetrafluoroborate (TOPPipU): An exellent coupling reagent in peptide chemistry." In Peptides 1992. Springer Netherlands, 1993. http://dx.doi.org/10.1007/978-94-011-1470-7_87.

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Kurusu, Yasuhiko. "Dioxygen Oxidation by the Metal-Immobilized Catalyst Derived from Silica and Montmorillonite Modified by Silane Coupling Reagent." In The Activation of Dioxygen and Homogeneous Catalytic Oxidation. Springer US, 1993. http://dx.doi.org/10.1007/978-1-4615-3000-8_57.

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El- Faham, Ayman, and Fernando Albericio. "Peptide-Coupling Reagents." In Amino Acids, Peptides and Proteins in Organic Chemistry. Wiley-VCH Verlag GmbH & Co. KGaA, 2011. http://dx.doi.org/10.1002/9783527631803.ch12.

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Kolb, Andreas, and Paultheo von Zezschwitz. "Organoaluminum Couplings to Carbonyls, Imines, and Halides." In Modern Organoaluminum Reagents. Springer Berlin Heidelberg, 2012. http://dx.doi.org/10.1007/3418_2012_39.

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Verma, Astha, and Webster L. Santos. "Copper-Catalyzed Coupling Reactions of Organoboron Compounds." In Boron Reagents in Synthesis. American Chemical Society, 2016. http://dx.doi.org/10.1021/bk-2016-1236.ch010.

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Conference papers on the topic "Coupling reagent"

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Zhang, Lei, Pu Liu, Lina Wang, Nan Zhang, Aimin Duan, and Xia Liu. "Advanced treatment of coking wastewater using three-dimensional electrode reactor coupling Fenton's reagent." In 2013 International Conference on Materials for Renewable Energy and Environment (ICMREE). IEEE, 2013. http://dx.doi.org/10.1109/icmree.2013.6893756.

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Bulavka, Vladimir. "Synthesis of some polycyclic aryls by haloaryl coupling with zinc dust – (trialkyl)ammonium formate reagent." In The 10th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2006. http://dx.doi.org/10.3390/ecsoc-10-01408.

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Nilsson, Johan, and Jacek Stawinski. "Oxidative coupling of H-phosphonate and H-phosphonothioate diesters. Iodine as a reagent and a catalyst." In XIIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2002. http://dx.doi.org/10.1135/css200205087.

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Zhang, Jin. "Notice of Retraction: Optimization of Coupling Effect of Oxidation and Flocculation in Removal of Algal Pollution with Fenton's Reagent." In 2011 5th International Conference on Bioinformatics and Biomedical Engineering. IEEE, 2011. http://dx.doi.org/10.1109/icbbe.2011.5781018.

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Skulski, Lech, and Lukasz Kraszkiewicz. "Facile Syntheses of Symmetrical Diaryliodonium Salts from Various Arenes, with Sodium Metaperiodate as the Coupling Reagent in Acidic Media." In The 9th International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2005. http://dx.doi.org/10.3390/ecsoc-9-01480.

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Khattab, Sherine N., Ramon Subirós-Funosas, Ayman El-Faham, and Fernando Albericio. "Organophosphinic Coupling Reagents in Peptide Synthesis." In Annual International Conference on Chemistry, Chemical Engineering and Chemical Process (CCECP 2014). GSTF, 2014. http://dx.doi.org/10.5176/2301-3761_ccecp14.20.

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Rosca, Sorin I. "New Carbon - Carbon Coupling Reactions Mediated by Aluminum, Chromium and Samarium Reagents." In the 39th American Romanian Academy of Arts and Sciences Congress. ARA Publisher, 2015. http://dx.doi.org/10.14510/39ara2015.3903.

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Česnek, Michal, Michal Hocek, and Antonín Holý. "Cross-coupling reactions of 2-amino-6-halopurine derivatives with organometallic reagents leading to 6-alkylated purine acyclic nucleotide analogues." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902255.

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Fernandez-Suarez, Miryam, Eduardo Garcia-Egido, Mickael Montembault, Maria J. Chapela, and Stephanie Y. F. Wong-Hawkes. "The Development of Integrated Microfluidic Chemistry Platforms for Lead Optimisation in the Pharmaceutical Industry." In ASME 4th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2006. http://dx.doi.org/10.1115/icnmm2006-96058.

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Abstract:
During the last decade, GlaxoSmithKline Pharmaceuticals (GSK) has carried out much of the seminal work in the area of micro fluidics and micro flow assay for lead optimisation. It has pioneered and built an in-house micro fluidic system for drug discovery. The huge and diverse advantages of this approach come from its miniaturised nature and its scale, which makes it easily automatable. As a result of its miniaturised nature it allows for greater control over heat and mass transfer, along with lower consumption of reagents (both chemical and biological) and solvents, less waste generation and decreased exposure to potentially toxic materials. But for a pharmaceutical company, the main advantage of this technology is the capability of coupling a fast microfluidic chemistry generator with a modern compatible miniaturised screening technique to generate instant biological information (i.e. the assay results) in “real time” that can be used to refine the chemistry (closing the feedback loop) and therefore allowing for a much faster lead optimisation. We will review some of the efforts within GSK towards this pioneering work in the development of miniaturised chemistry platforms capable of performing multiple functions such as synthesis, separation, quantification and screening.
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