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Dissertations / Theses on the topic 'Covalent compounds'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Thompson, Vanessa R. "Covalent Protein Adduction of Nitrogen Mustards and Related Compounds." FIU Digital Commons, 2014. http://digitalcommons.fiu.edu/etd/1152.

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Chemical warfare agents continue to pose a global threat despite the efforts of the international community to prohibit their use in warfare. For this reason, improvement in the detection of these compounds remains of forensic interest. Protein adducts formed by the covalent modification of an electrophilic xenobiotic and a nucleophilic amino acid may provide a biomarker of exposure that is stable and specific to compounds of interest (such as chemical warfare agents), and have the capability to extend the window of detection further than the parent compound or circulating metabolites. This re

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2

Kui, Chi-fai. "Non-covalent weak interactions in group IV, PT(II) and AU(I) organometallic complexes synthesis, structures and properties /." Click to view the E-thesis via HKUTO, 2005. http://sunzi.lib.hku.hk/hkuto/record/B32021331.

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3

Kueh, Alona Swee Hua. "Molecular imprinting of small, poorly functionalised organic compounds." The University of Waikato, 2008. http://hdl.handle.net/10289/2264.

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Molecularly imprinted polymers (MIPs) have been compared to natural antibodies in that they can specifically bind target compounds in a similar way that antibodies specifically bind to an antigen. The attraction of the MIPs technology is the ease of creating binding elements which are relatively cheap compared with the process of isolating natural antibodies. In this research monoterpenes, such as α-terpineol, were chosen to be the model compounds for investigating the molecular imprinting of small, poorly functionalised organic compounds. The conventional non-covalent approach was mainly u

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4

Izquierdo-Cabezudo, Raúl-Alfonso. "Mass spectrometry of cationic compounds and their non covalent adducts with oligonucleotides." Doctoral thesis, Universidade de Aveiro, 2006. http://hdl.handle.net/10773/4932.

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Doutoramento em Química<br>O objectivo do presente trabalho é a aplicação da espectrometria de massa e espectrometria de massa tandem, ambas com ionização por electrospray (ESIMS e ESI-MS/MS respectivamente) nos modos positivo e negativo ao estudo de compostos catiónicos e das suas interacções com oligonucleotídeos. Usando ESI-MS e ESI-MS/MS no modo positivo, estudaram-se clorinas e isobacterioclorinas catiónicas com anéis de pirrolidina fundidos ao macrociclo. Estes compostos sofrem reacções de cicloreversão em fase gasosa que ocorrem por eliminação de espécies neutras ou carregadas. N

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5

Kui, Chi-fai, and 居智輝. "Non-covalent weak interactions in group IV, PT(II) and AU(I) organometallic complexes: synthesis,structures and properties." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2005. http://hub.hku.hk/bib/B32021331.

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6

Lee, Eun-ju. "The study of molecular assemblies formed via non-covalent interactions between calixarenes /." free to MU campus, to others for purchase, 2003. http://wwwlib.umi.com/cr/mo/fullcit?p1418042.

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7

Griffiths, John Robert. "Structural studies using ion mobility spectrometry." Thesis, Nottingham Trent University, 2001. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.366069.

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8

Liebenberg, Liesl Eileen. "Non-covalent immobilisation of a ligand system : a new approach to affinity separation." Thesis, Stellenbosch : Stellenbosch University, 2003. http://hdl.handle.net/10019.1/53522.

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Thesis (MSc)--Stellenbosch University, 2003.<br>ENGLISH ABSTRACT: Advances in pharmacology, biochemistry and biotechnology are increasingly dependant upon affinity chromatography as a preferred separation technique for the purification and characterisation of specific biomolecules. In the past few years avidin-biotin technology has been widely and successfully used in the fields of medicine, pharmacy, biology and biochemistry. The avidin-biotin complex (ABC) has been used as a mediator for affinity chromatography, affinity cytochemistry, immunoassay, histopathology, bioaffinity sensors,

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9

Moniodis, Joseph John. "Studying the DNA binding of a non-covalent analogue of the trinuclear platinum anticancer agent BBR3464." University of Western Australia. School of Biomedical, Biomolecular and Chemical Sciences, 2006. http://theses.library.uwa.edu.au/adt-WU2007.0008.

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[Truncated abstract] The Phase II clinical candidate, [(trans-Pt(NH3)2Cl)2{μ-trans-Pt(NH3)2(H2N(CH2)6NH2)2}]4+ (BBR3464 or 1,0,1/t,t,t) shows a unique binding profile when compared to the anticancer agent cis-[Pt(NH3)2Cl2] (cisplatin) and dinuclear platinum complexes of the general formula [(trans-Pt(NH3)2Cl)2(H2N(CH2)nNH2)]2+. There is evidence that the increased efficacy of 1,0,1/t,t,t results from the presence of the charged central linker, which can alter the mode of binding to DNA. This alternate binding mode may be due to an electrostatic and hydrogen bonding association of the central p

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10

Mohler, Linda Kay. "Synthesis and study of arylboronic acid derivatives for covalent recognition and transport of neutral water soluble compounds /." The Ohio State University, 1993. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487846885776126.

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11

Gahlot, Sapna. "Asterisk-shaped arenes and heteroarenes incorporating sulfur, oxygen and nitrogen : synthesis, structures, photophysics, dynamic and supramolecular covalent chemistry." Electronic Thesis or Diss., Aix-Marseille, 2022. http://www.theses.fr/2022AIXM0097.

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Le contenu de cette thèse porte sur les astérisques moléculaires fonctionnalisés, ramifiés et polysulfurés, polyoxygénés ou polycyanés incorporant soit un noyau benzénique, un noyau pyridine, ou un noyau pyrène. Les principaux objectifs sont de rapporter la synthèse et les propriétés structurales, photophysiques, supramoléculaires et covalentes dynamiques des architectures moléculaires nouvellement créées, afin de développer d'autres utilisations et applications de celles-ci dans un futur proche, vers l'électronique moléculaire, l'imagerie, les sciences des matériaux et de la vie. Elle interro

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12

Mangrum, John. "ELECTROSPRAY IONIZATION MASS SPECTROMETRY FOR THE CHARACTERIZATION OF COVALENT AND NONCOVALENT POLYNUCLEAR PLATINUM COMPOUNDS INTERACTING WITH BIO-MOLECULES." VCU Scholars Compass, 2010. http://scholarscompass.vcu.edu/etd/2151.

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Polynuclear platinum compounds represent a new class of potential platinum anticancer therapeutics. Derived from the most widely used platinum anticancer drug, cisplatin, these novel compounds are distinct in their interactions with bio-molecules. The effectiveness of platinum anticancer agents is influenced by three pharmacological factors: (i) their resistance to deactivating sulfur nucleophiles, (ii) the ability to gain cellular entry and efficient cellular uptake, and (iii) the ability to form stable and specific complexes with DNA. BBR 3464, the first multinuclear platinum compound to

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13

Knaggs, Jonathan David. "The modulation of Transient Receptor Potential A1 channel by natural and novel semi-synthetic compounds via non-covalent modification." Thesis, University of Hull, 2016. http://hydra.hull.ac.uk/resources/hull:15136.

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Transient Receptor Potential A1 (TRPA1) is commonly known as the detector of a broad range of noxious chemical agents both exogenous and endogenous. TRPA1 detects these chemicals through a reversible covalent modification mechanism that allows most electrophilic compounds to activate the channel; hence one of the channel’s key roles is to protect the respiratory system from harmful irritants by activating the cough reflex. It has been proposed that TRPA1 is involved in chronic inflammatory diseases of the respiratory system and has been highlighted as a potential drug target for this as well a

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14

GALBIATI, ANDREA. "DESIGN AND SYNTHESIS OF NOVEL ENZYME INHIBITORS AS ANTIPROLIFERATIVE COMPOUNDS WITH ANTIPROTOZOAL AND ANTICANCER ACTIVITY." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/827428.

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This dissertation describes the research carried out as part of a PhD program in Chemistry from the 1st October 2017 until 30th November 2020. The PhD project investigated the development of inhibitors of enzymes involved in important metabolic pathways, with the final aim to produce an antiproliferative effect. The present thesis combines the works performed at the University of Milan and Vrije Universiteit of Amsterdam. Part A describes the research performed in Amsterdam, NL during my period abroad from January to September 2019 in the research group of Professor Rob Leurs, at the Di

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15

Peña, Gomez Natalie. "Development of polymeric and silica filtering materials functionalized with antimicrobial compounds for the elimination of microorganisms in liquid food." Doctoral thesis, Universitat Politècnica de València, 2020. http://hdl.handle.net/10251/137041.

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[ES] En la presente tesis doctoral se ha evaluado el uso de nuevos soportes celulósicos y silíceos como sistemas de filtración para la estabilización y conservación de alimentos líquidos con el fin de afrontar dos grandes retos de la industria de bebidas. Por un lado, evitar o minimizar los cambios en las propiedades nutricionales, estructurales y organolépticas de los alimentos, ocasionados por la pasteurización térmica tradicional, y ofrecer una alternativa al problema de la baja viabilidad debida a los altos costos de inversión/producción al aplicar nuevas tecnologías no térmicas. Por ello,

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16

Martín-Gago, Pablo. "Synthesis of Highly Structured and Receptor-Selective Tetradecapeptidic Analogs of Somatostatin: Fine-tuning the non-covalent interactions among their aromatic residues." Doctoral thesis, Universitat de Barcelona, 2013. http://hdl.handle.net/10803/128565.

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Somatostatin, a peptidic hormone also known as somatotropin release-inhibiting factor (SRIF), is implicated in multiple biological functions, mediated by direct interaction of the peptide with a family of structurally related, G-protein coupled transmembrane receptors (GPCRs), named SSTR1-5. However, the full therapeutic potential of SRIF cannot be further exploited owing to its short half-life of <3 min in plasma and its lack of selectivity against all receptors. With the aim to overcome these limitations, many SRIF analogs containing key modifications have been synthesized over recent decade

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17

Kotze, Izak Aldert. "Self-association of [PtII(1,10-Phenanthroline)(N-pyrrolidyl-N-(2,2-dimethyl-propanoyl)thiourea)]+ and non-covalent outer-sphere complex formation with fluoranthene through cation-π interactions : a high resolution 1H and DOSY NMR study". Thesis, Stellenbosch : University of Stellenbosch, 2009. http://hdl.handle.net/10019.1/1796.

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18

Bojdys, Michael Janus. "On new allotropes and nanostructures of carbon nitrides." Phd thesis, Universität Potsdam, 2009. http://opus.kobv.de/ubp/volltexte/2010/4123/.

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In the first section of the thesis graphitic carbon nitride was for the first time synthesised using the high-temperature condensation of dicyandiamide (DCDA) – a simple molecular precursor – in a eutectic salt melt of lithium chloride and potassium chloride. The extent of condensation, namely next to complete conversion of all reactive end groups, was verified by elemental microanalysis and vibrational spectroscopy. TEM- and SEM-measurements gave detailed insight into the well-defined morphology of these organic crystals, which are not based on 0D or 1D constituents like known molecular or sh

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19

Kulchat, Sirinan. "Dynamic covalent chemistry of C=N, C=C and quaternary ammonium constituents." Thesis, Strasbourg, 2015. http://www.theses.fr/2015STRAF018/document.

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Cette thèse décrit la Chimie Covalente Dynamique (CCD) des échanges imine/imine, Knoevenagel/imine et Knoevenagel/Knoevenagel. La L-proline est un excellent organocatalyseur pour la formation de Bibliothèques Covalentes Dynamiques (BCDs). Cependant, l’interconversion entre des dérivées Knoevenagel de l’acide diméthylbarbiturique et des imines se déroule rapidement sans catalyseur. Une nouvelle classe de CCD basée sur des échanges par substitutions nucléophiles (SN2/SN2’) entre des sels d’ammonium quaternaires et des amines tertiaires est développée, impliquant la catalyse par l’iodure. Les réa

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20

Kenfack, Tsobnang Patrice. "Synthèse, caractérisation et étude du comportement à la déshydratation par diffraction des rayon X sur monocristal et poudre, de quelques composés supramoléculaires à base de métallo-tectons ioniques." Thesis, Université de Lorraine, 2014. http://www.theses.fr/2014LORR0243/document.

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Ce travail réalisé dans le cadre de l’initiative africaine de l’IUCr porte sur l’étude structurale par diffraction des rayons X de quelques architectures élaborées par association, via des interactions faibles, des anions {[M(C2O4)3]3-,M = Cr, Fe} et des cations complexes à base de la 2-picolylamine (amp) métaux de transition (Co2+, Cu2+ et Mn2+). L’architecture à base de l’ion Co2+ est bidimensionnelle et présente des feuillets ondulés constitués de chaines bimétalliques de chiralité différente où les deux ions complexes ([Cr(C2O4)3]3- et [Co(amp)3]3+ ) sont connectés par des liaisons hydrogè

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21

Moreira, Ana Sofia Pereira. "Study of modifications induced by thermal and oxidative treatment in oligo and polysaccharides of coffee by mass spectrometry." Doctoral thesis, Universidade de Aveiro, 2016. http://hdl.handle.net/10773/17074.

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Doutoramento em Bioquímica<br>Os polissacarídeos são os componentes maioritários dos grãos de café verde e torrado e da bebida de café. Os mais abundantes são as galactomananas, seguindo-se as arabinogalactanas. Durante o processo de torra, as galactomananas e arabinogalactanas sofrem modificações estruturais, as quais estão longe de estar completamente elucidadas devido à sua diversidade e à complexidade estrutural dos compostos formados. Durante o processo de torra, as galactomananas e arabinogalactanas reagem com proteínas, ácidos clorogénicos e sacarose, originando compostos castanh

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22

Maria, Thomas Chriso. "Construction of porous supramolecular frameworks assembled from covalent cage compounds." Phd thesis, 2021. http://hdl.handle.net/1885/247908.

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This thesis describes the synthesis of cage molecules using covalent and non-covalent interactions and approaches to covalently modify the organic cages to form frameworks. Chapter 1 is an introduction to the field of supramolecular chemistry discussing the types of non-covalent interactions that can be used for self-assembly. It details the types of porous materials that are known with a focus on porous organic solids relevant to the thesis. Chapter 2 details the synthesis of covalent organic cages via threefold Eglinton coupling reactions and crystal packing studies of the resulting cages

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23

Kagiampakis, Ioannis. "Improving the Anti-HIV Potency of Different Compounds through Synergy and Covalent Linkage: Dimerization Studies of CXCL8." Thesis, 2010. http://hdl.handle.net/1969.1/ETD-TAMU-2010-08-8512.

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In the first part of my dissertation we focused on the development of covalently linking compounds that bind gp120 with those that bind gp41 in order to block HIV fusion. We used griffithsin or CD4M33, that both bind to gp120, covalently linked with C-peptide C37 of gp41. The results show the linked compound Griff37 is several-fold more potent than griffithsin alone in both fusion and viral assay, making Griff37 an attractive candidate for further development as a microbicide against HIV. In the second part of my dissertation we investigate the effect of combining HIV fusion inhibitors having

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24

HSING-FANG, CHIANG, and 江幸芳. "(a)Synthesis, Characterization, Structure and Studies of metal complexes with short Fluoro-ponytailed Bipyridine Ligands Possessing Halogen (Halogen Bonding) (b)Studies of The Non-Covalent Bonds of Flourous Compounds as Electron Acceptor or Donor." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/qsxrh7.

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碩士<br>國立臺北科技大學<br>有機高分子研究所<br>105<br>(a) Our Lab has been started to synthesize polyfluorinated compounds and promoted their recognition considerably. On continuation of our prior studies, I synthesized Bipyridine ligands having terminal Halogen and its palladium / platinum metal complexes in the research to study their structural properties. The reaction of bipyridine ligands with Palladium and Platinum Metals to generate their corresponding Metal complexes. The synthesized ligands and their metal complexes have been characterized using IR, NMR, Single Crystal X-ray diffraction, and Melting

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25

Beaudoin, Daniel. "Préparation de réseaux organiques covalents monocristallins par polymérisation de composés polynitroso aromatiques." Thèse, 2014. http://hdl.handle.net/1866/12300.

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26

Nekardová, Michaela. "Výpočetní studie interakcí malých molekul s jejich biologickými cíly." Doctoral thesis, 2020. http://www.nusl.cz/ntk/nusl-411413.

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The thesis specializes in the computational description of pharmaceutically important compounds. A substantial number of pharmaceutical drugs are small molecules that are bound to an active site of an enzyme by the "lock (binding site) and key (drug)" model through non-covalent interactions. The association of enzymes with drugs cause an increase or decrease in the activity of enzymes. The main topic is focused on the computational elucidation of the structural basis for the interactions of the purine-like compounds with the enzyme cyclin- dependent kinase 2 that belongs to the protein-kinase

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27

"Synthesis of covalently-linked porphyrin-quinones and their metal complexes." Chinese University of Hong Kong, 1993. http://library.cuhk.edu.hk/record=b5887808.

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by Chi-Shing Chan.<br>Thesis (M.Phil.)--Chinese University of Hong Kong, 1993.<br>Includes bibliographical references (leaves 62-65).<br>Acknowledgements --- p.i<br>Contents --- p.ii<br>Abbreviations --- p.iii<br>Abstract --- p.1<br>Introduction --- p.2-8<br>Synthetic Strategy --- p.9-12<br>Results and Discussion<br>Chapter A. --- Synthesis of the aryl triflate substituted and aryl bromide substituted porphyrins --- p.13-15<br>Chapter B. --- Synthesis of the (alkynyl)phenyl substituted porphyrins --- p.16-19<br>Chapter C --- Benzannulation of Fischer carbene complexes with (alkynyl)ph

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