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1

Lin, Ming-Kuem, Meng-Shiou Lee, Hui-Chi Huang, Tun-Jen Cheng, Yih-Dih Cheng, and Chi-Rei Wu. "Cuscuta chinensis and C. campestris Attenuate Scopolamine-Induced Memory Deficit and Oxidative Damage in Mice." Molecules 23, no. 12 (2018): 3060. http://dx.doi.org/10.3390/molecules23123060.

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The seeds of Cuscuta chinensis Lam. and C. campestris Yuncker have been commonly used as Chinese medical material for preventing aging. Our previous studies have found that C. chinensis and C. campestris possess anti-inflammatory activities in rodents. However, their other biological activities, such as memory-improving properties, have not yet been explored. In the present study, we examined the memory-improving effects of the extracts of C. chinensis and C. campestris on scopolamine (SCOP)-induced memory deficit and explored their underlying mechanism in mice. Both Cuscuta species improved SCOP-induced memory deficits in the passive avoidance test, elevated plus-maze, and spatial performance test of the Morris water maze in mice. In addition, compared with mice injected with SCOP, mice pretreated with both Cuscuta species stayed for a longer time on the platform for the probe test of the Morris water maze. Moreover, both Cuscuta species reduced brain acetylcholinesterase activity and malondialdehyde levels that were increased by SCOP, and the species restored the activities of antioxidant enzymes (superoxide dismutase and catalase) and the levels of glutathione that were decreased by SCOP in the brains of mice. Both Cuscuta species further decreased brain interleukin-1β and tumor necrosis factor-α levels that were elevated by SCOP. We demonstrated that both Cuscuta species exhibited a protective activity against SCOP-induced memory deficit, cholinergic dysfunction, oxidative damage, and neuroinflammation in mice, and C. campestris has better potential than C. chinensis. In addition, we provided evidence that the seeds of C. campestris can be used as Cuscutae Semen in Traditional Chinese Medicine.
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2

Park, Inkyu, Jun-Ho Song, Sungyu Yang, Wook Jin Kim, Goya Choi, and Byeong Cheol Moon. "Cuscuta Species Identification Based on the Morphology of Reproductive Organs and Complete Chloroplast Genome Sequences." International Journal of Molecular Sciences 20, no. 11 (2019): 2726. http://dx.doi.org/10.3390/ijms20112726.

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The genus Cuscuta (Convolvulaceae) comprises well-known parasitic plants. Cuscuta species are scientifically valuable, as their life style causes extensive crop damage. Furthermore, dried seeds of C. chinensis are used as a Korean traditional herbal medicine. Despite the importance of Cuscuta species, it is difficult to distinguish these plants by the naked eye. Moreover, plastid sequence information available for Cuscuta species is limited. In this study, we distinguished between C. chinensis and C. japonica using morphological characterisation of reproductive organs and molecular characterisation of chloroplast genomes. The differences in morphological characteristics of reproductive organs such as style, stigma, infrastaminal scale, seed shape and testa ornamentation were useful for distinguishing between C. japonica and C. chinensis. Analysis of chloroplast genomes revealed drastic differences in chloroplast genome length and gene order between the two species. Although both species showed numerous gene losses and genomic rearrangements, chloroplast genomes showed highly similar structure within subgenera. Phylogenetic analysis of Cuscuta chloroplast genomes revealed paraphyletic groups within subgenera Monogynella and Grammica, which is consistent with the APG IV system of classification. Our results provide useful information for the taxonomic, phylogenetic and evolutionary analysis of Cuscuta and accurate identification of herbal medicine.
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3

Lu, Menglin, and Xiaojie Liu. "Investigation on The Distribution of Cuscuta in Chengdu." Highlights in Science, Engineering and Technology 2 (June 22, 2022): 200–210. http://dx.doi.org/10.54097/hset.v2i.574.

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Cuscuta is an annual parasitic herb in Convolvulaceae family Cuscuta. This project investigated the spread of cuscuta in 12 towns and 1 street that have 71 plots of the Chengdu, Tianfu New District by selecting a certain area of strip and circular plots, and proved the distribution pattern and growth situation of cuscuta in this area. The results showed that: (1) Cuscuta in this area 1 genus 2 species, respectively for Cuscuta chinensis and Cuscuta japonica, of which Cuscuta chinensis accounted for 80%, the Cuscuta japonica accounted for 20%; (2) The two cuscuta species parasitized 40 plants of 30 families, 37 genera in 14 sites, and three host plants of Magnoliaceae were found for the first time in this survey. (3) The parasitism of the cuscuta showed the following pattern: plot afforestation > road afforestation > park afforestation > unmanaged wasteland, and the host plant species of plot afforestation was the largest, and the infection of road afforestation was the most serious. (4) Cuscuta for the parasitic environment sel-ection tends to high light intensity, air humidity about 80%, high plant density, more plant species conditions, in the selection of the parasitic site, is more likely to appear in the middle and upper region of the host plant. The results of this project can provide a theoretical reference for the studyof local landscape protection, and provide a theoretical basis for the development of local greening and tree cultivation.
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4

Xiang, Sheng-Xi, Zhi-Sheng He, and Yang Ye. "Furofuran Lignans from Cuscuta chinensis." Chinese Journal of Chemistry 19, no. 3 (2010): 282–85. http://dx.doi.org/10.1002/cjoc.20010190314.

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5

Zhang, Quanzhong, and Jinming Hu. "Do Faster-Growing Holoparasitic Plant Species Exhibit Broader Niches and Wider Global Distributions?" Plants 14, no. 6 (2025): 831. https://doi.org/10.3390/plants14060831.

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Parasitic organisms, as an important component of ecosystems, have long been a focal point in ecological research, particularly concerning the relationship between their growth characteristics, ecological niche, and distribution patterns. This study selects the holoparasitic plant species Cuscuta campestris Yunck., Cuscuta australis R.Br., and Cuscuta chinensis Lam. from the Cuscuta subgenus Grammica as model species to explore the relationship between the growth rate, ecological niche breadth, and global distribution patterns of parasitic plants. Through greenhouse experiments and data analysis, the main findings of this study indicate a strong positive correlation between the growth rate, ecological niche breadth, number of global occurrence points, and global distribution area for C. campestris, C. australis, and C. chinensis. The significant correlation between growth rate and ecological niche breadth suggests that the intrinsic growth characteristics of parasitic plants may significantly influence their realized ecological niche. Furthermore, the experimental results show that when C. campestris, C. australis, and C. chinensis parasitize non-native hosts from the Americas, they produce greater biomass than when parasitizing native hosts from China. In conclusion, this study provides new support for ecological theories regarding species adaptability, distribution patterns, and environmental influences, and offers directions for future research.
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6

Du, Kun-ze, Jin Li, Xinrong Guo, Yuhong Li, and Yan-xu Chang. "Quantitative Analysis of Phenolic Acids and Flavonoids in Cuscuta chinensis Lam. by Synchronous Ultrasonic-Assisted Extraction with Response Surface Methodology." Journal of Analytical Methods in Chemistry 2018 (December 20, 2018): 1–10. http://dx.doi.org/10.1155/2018/6796720.

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An effective ultrasonic-assisted extraction method for the separation of phenolic acids and flavonoids in Cuscuta chinensis Lam. was conducted by combining uniform design (UD) coupled with response surface methodology (RSM) and orthogonal design (OD) experiment. A sensitive and selective high-performance liquid chromatography-electrospray ionization tandem triple quadrupole mass spectrometry (HPLC-ESI-MS/MS) method was applied to quantify the sixteen active ingredients (chlorogenic acid, cryptochlorogenic acid, neochlorogenic acid, isochlorogenic acid A, isochlorogenic acid B, isochlorogenic acid C, caffeic acid, hyperin, isoquercitrin, quercetin, campherol, p-coumaric acid, isorhamnetin, rutin, astragalin, and apigenin). The extraction method was optimized with respect to concentration of extraction solvent, extraction time, and ratio of liquid to solid as a consequence of getting a high sensitive and feasible method for simultaneous determination of contents of multiple components and evaluation of quality control of Cuscuta chinensis Lam. from different origins. It was also considered useful and valuable in the further study for quality control of Cuscuta chinensis Lam.
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7

Park, Inkyu, Sungyu Yang, Goya Choi, Byeong Cheol Moon, and Jun-Ho Song. "An Integrated Approach for Efficient and Accurate Medicinal Cuscutae Semen Identification." Plants 9, no. 11 (2020): 1410. http://dx.doi.org/10.3390/plants9111410.

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To guarantee the safety and efficacy of herbal medicines, accurate identification and quality evaluation are crucial. The ripe dried seeds of Cuscuta australis R.Br. and C. chinensis Lam. are known as Cuscutae Semen (CS) and are widely consumed in Northeast Asia; however, the seeds of other species can be misidentified as CS owing to morphological similarities, leading to misuse. In this report, we propose a multilateral strategy combining microscopic techniques with statistical analysis and DNA barcoding using a genus-specific primer to facilitate the identification and authentication of CS. Morphology-based identification using microscopy revealed that the useful diagnostic characteristics included general shape, embryo exudation, hairiness, and testa ornamentation, which were used to develop an effective identification key. In addition, we conducted DNA barcoding-based identification to ensure accurate authentication. A novel DNA barcode primer was produced from the chloroplast rbcL gene by comparative analysis using Cuscuta chloroplast genome sequences, which allowed four Cuscuta species and adulterants to be discriminated completely. Therefore, this investigation overcame the limitations of universal DNA barcodes for Cuscuta species with high variability. We believe that this integrated approach will enable CS to be differentiated from other species, thereby improving its quality control and product safety in medicinal markets.
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8

Al-Sudani, Basma Talib, Nadia H. Mohammed, and Fadia H. Al-Sultany. "Redounding of Cuscuta chinensis Lam. on BxPC-3, HepG2, and U2OS Human Cancer Cell Lines." International Journal of Drug Delivery Technology 10, no. 03 (2020): 354–59. http://dx.doi.org/10.25258/ijddt.10.3.8.

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Objective: The present study was designed to investigate in vitro cytotoxic effect of aqueous extract from whole Cuscuta chinensis on human hepatocellular carcinoma (HepG2), biopsy xenograft of pancreatic carcinoma line-3 (BxPC-3), and children human bone osteosarcoma cell line (U2OS). Materials and Methods: The anticancer effectiveness of the methanol-watery extract of C. chinensis Lam. was determined by using methyl tetrazolium bromide test (MTT) assay against cancer cells by using suspensions of BxPC-3, HepG2, and U2OS cell lines. The inhibitory concentration (IC50) was tested for each cancer cell line. BxPC-3, HepG2, and U2OS cell line death percent after incubation with extract for 24, 48, and 72-hours interval was compared with cisplatin death percent. Results: The results showed that the IC50 of Cuscuta extract for BxPC-3, HepG2, and U2OS cell lines was 13, 6.5, and 0.73 μg/mL, respectively. The HepG2 cell line death%, when treated with 50 μg/mL Cuscuta extract at 24, 48, and 72-hour time interval, was 90.41, 91.45, and 92.93%, while cells were treated with 15 μg/mL cisplatin, the death percent was 88.8, 93.7, and 96.61%, respectively. The BxPC-3 cell line death%, when treated with 50 μg/mL Cuscuta extract, was 51.46, 83.37, and 91.28%, respectively, and when treated with 15 μg/mL cisplatin was 81.64, 88.02, and 96.67%, respectively. The U2OS cell line death%, when treated with 50 μg/mL Cuscuta extract, was 69.43, 69.75, and 88.89%, and was 74.1, 84.61, and 93.39%, respectively, when treated with 15 μg/mL cisplatin. Conclusion: The methanol-watery extract of C. chinensis Lam. may have a potential role as an adjunct therapy for cancers in the future.
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9

Yang, Lijuan, Qianfeng Chen, Fei Wang, and Guolin Zhang. "Antiosteoporotic compounds from seeds of Cuscuta chinensis." Journal of Ethnopharmacology 135, no. 2 (2011): 553–60. http://dx.doi.org/10.1016/j.jep.2011.03.056.

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10

Azadeh, Kiani Ali Firoozabadi *. Alireza Salehi Gholamreza Amin Hossein Rezaeizadeh Leila Abdi Abbas Tavallaii. "EFFECTS OF CUSCUTA CHINENSIS LAM. VERSUS FLUOXETINE FOR TREATMENT OF MAJOR DEPRESSION: A DOUBLE-BLIND, RANDOMIZED CONTROLLED TRIAL." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 01 (2018): 278–87. https://doi.org/10.5281/zenodo.1147442.

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Background: Depression is a common psychiatric disorder and a major worldwide health problem. Although several pharmaceutical agents are available for the treatment of depression, they are sometimes ineffective because patients cannot tolerate the side effects and stop taking their medication. Many herbs can play an important role in the treatment of psychiatric disorders with fewer side effects.Objective: To compare the efficacy of Cuscuta chinensis with fluoxetine in the treatment of major depression.Design and setting: Sixty-eight adult outpatients who met the criteria for major depression based on the structured clinical interview as defined by the Diagnostic and Statistical Manual of Mental Disorders (5th edition) participated in a six-week two-armed double-blind randomized controlled trial.Intervention: Patients were randomly assigned to receive C. chinensis or fluoxetine for six weeks.Outcome measures: Both groups filled out the Beck Depression Inventory (BDI-II) and a questionnaire to evaluate side effects at baseline and at 2, 4 and 6 weeks after onset of treatment.Results: The C. chinensis group recorded a significant decrease in BDI-II scores compared to the fluoxetine group (p < 0.001). There were no significant differences between groups in terms of observed side effects; however, some complications were significantly lower in the C. chinensis group compared to the fluoxetine group.Conclusion: C. chinensis appears to have antidepressant properties with fewer side effects. This herb is effective and safe in the treatment of major depression and could be administered to depressed patients. Keywords: Cuscuta chinensis; Major depressive disorder; Herbal medicine; Fluoxetine; Traditional Persian Medicine.
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11

Wang, Jing, Dongdong Tan, Guangzheng Wei, et al. "Studies on the Chemical Constituents of Cuscuta chinensis." Chemistry of Natural Compounds 52, no. 6 (2016): 1133–36. http://dx.doi.org/10.1007/s10600-016-1886-y.

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12

Nitthikan, Nichcha, Weeraya Preedalikit, Kanittapon Supadej, Siripat Chaichit, Pimporn Leelapornpisid, and Kanokwan Kiattisin. "Exploring the Wound Healing Potential of a Cuscuta chinensis Extract-Loaded Nanoemulsion-Based Gel." Pharmaceutics 16, no. 5 (2024): 573. http://dx.doi.org/10.3390/pharmaceutics16050573.

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Cuscuta chinensis (C. chinensis) presents many pharmacological activities, including antidiabetic effects, and antioxidant, anti-inflammatory, and antitumor properties. However, the wound care properties of this plant have not yet been reported. Therefore, this research aimed to evaluate the antioxidant, anti-inflammatory, and antibacterial activities of ethanol and ethyl acetate C. chinensis extracts. The phytochemical markers in the extracts were analyzed using high-performance liquid chromatography (HPLC). Then, the selected C. chinensis extract was developed into a nanoemulsion-based gel for wound care testing in rats. The results showed that both of the C. chinensis extracts exhibited antioxidant activity when tested using 2,2-Diphenyl-1-picrylhydrazyl (DPPH), ferric reducing antioxidant power (FRAP), and lipid peroxidation inhibition assays. They reduced the expression of IL-1β, IL-6, and TNF-α in RAW264.7 cells induced with lipopolysaccharide (LPS). The ethyl acetate extract also had antibacterial properties. Kaempferol was found in both extracts, whereas hyperoside was found only in the ethanol extract. These compounds were found to be related to the biological activities of the extracts, confirmed via molecular docking. The C. chinensis extract-loaded nanoemulsions had a small particle size, a narrow polydispersity index (PDI), and good stability. Furthermore, the C. chinensis extract-loaded nanoemulsion-based gel had a positive effect on wound healing, presenting a better percentage wound contraction Fucidin cream. In conclusion, this formulation has the potential for use as an alternative wound treatment and warrants further study in clinical trials.
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13

Stefanović, Mihai Costea Ian Spence Saša. "Systematics of Cuscuta chinensis species complex (subgenus Grammica, Convolvulaceae): evidence for long-distance dispersal and one new species." Organisms Diversity & Evolution 11, no. 5 (2011): 373–86. https://doi.org/10.1007/s13127-011-0061-3.

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Stefanović, Mihai Costea Ian Spence Saša (2011): Systematics of Cuscuta chinensis species complex (subgenus Grammica, Convolvulaceae): evidence for long-distance dispersal and one new species. Organisms Diversity & Evolution (New York, N.Y.) 11 (5): 373-386, DOI: 10.1007/s13127-011-0061-3, URL: http://dx.doi.org/10.1007/s13127-011-0061-3
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14

Wang, Hanze, Xiaomeng Hou, Bingqi Li, Yang Yang, Qiang Li, and Yinchu Si. "Study on Active Components of Cuscuta chinensis Promoting Neural Stem Cells Proliferation: Bioassay-Guided Fractionation." Molecules 26, no. 21 (2021): 6634. http://dx.doi.org/10.3390/molecules26216634.

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Neural stem cells (NSCs) exist in the central nervous system of adult animals and capable of self-replication. NSCs have two basic functions, namely the proliferation ability and the potential for multi-directional differentiation. In this study, based on the bioassay-guided fractionation, we aim to screen active components in Cuscuta chinensis to promote the proliferation of NSCs. CCK-8 assays were used as an active detection method to track the active components. On the basis of isolating active fraction and monomer compounds, the structures of these were identified by LC-MS and (1H, 13C) NMR. Moreover, active components were verified by pharmacodynamics and network pharmacology. The system solvent extraction method combined with the traditional isolation method were used to ensure that the fraction TSZE-EA-G6 of Cuscuta chinensis exhibited the highest activity. Seven chemical components were identified from the TSZE-EA-G6 fraction by UPLC-QE-Orbitrap-MS technology, which were 4-O-p-coumarinic acid, chlorogenic acid, 5-O-p-coumarinic acid, hyperoside, astragalin, isochlorogenic acid C, and quercetin-3-O-galactose-7-O-glucoside. Using different chromatographic techniques, five compounds were isolated in TSZE-EA-G6 and identified as kaempferol, kaempferol-3-O-glucoside (astragalin), quercetin-3-O-galactoside (hyperoside), chlorogenic acid, and sucrose. The activity study of these five compounds showed that the proliferation rate of kaempferol had the highest effects; at a certain concentration (25 μg/mL, 3.12 μg/mL), the proliferation rate could reach 87.44% and 59.59%, respectively. Furthermore, research results using network pharmacology techniques verified that kaempferol had an activity of promoting NSCs proliferation and the activity of flavonoid aglycones might be greater than that of flavonoid glycosides. In conclusion, this research shows that kaempferol is the active component in Cuscuta chinensis to promote the proliferation of NSCs.
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Wu, Hai-wang, Yi-hui Feng, Dong-ying Wang, et al. "Effect of Total Flavones from Cuscuta Chinensis on Anti-Abortion via the MAPK Signaling Pathway." Evidence-Based Complementary and Alternative Medicine 2018 (October 2, 2018): 1–12. http://dx.doi.org/10.1155/2018/6356190.

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For centuries, the Chinese herb Cuscuta chinensis has been applied clinically for abortion prevention in traditional Chinese medicine (TCM). Total flavones extracted from Cuscuta chinensis (TFCC) are one of the active components in the herb and also display anti-abortion effect similar to the unprocessed material. However, how TFCC exerts the anti-abortion effect remains largely unknown. In this study, we aim at characterizing the anti-abortion effects of TFCC and its underlying molecular mechanism in vitro and in vivo using human primary decidua cells and a mifepristone-induced abortion model in rat, respectively. The damage to the decidua caused by mifepristone in vivo was reversed by TFCC treatment in a dosage-dependent manner. High dosage of TFCC significantly upregulated the expression of estrogen receptor (ER), progesterone receptor (PR), and prolactin receptor (PRLR) in decidua tissue but downregulated the expression of p-ERK. Furthermore, we detected higher level of p-ERK and p-p38 in primary decidua cells from spontaneous abortion while treatment by TFCC downregulated their expression. Our results suggest TFCC mediates its anti-abortion effect by interfering with MAPK signaling pathway.
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Wong, Nyet Kui, Yong Min Teo, Yan Hong Er, and Soi Moi Chye. "Toxicity Effects of Chinese Herbal ‘Five-seeds’ Formulation on Human Kidney HEK-293 and Chang Liver Cells." ASM Science Journal 15 (May 17, 2021): 1–12. http://dx.doi.org/10.32802/asmscj.2021.637.

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‘Five-seeds’ formulation (Lycium barbarum, Cuscuta chinensis Lam, Rubus idaeus, Schisandra chinensis, Plantago asiatica) have been used by Chinese medicine practitioner for the treatment of male infertility for a long time. The present study aims to investigate the potential toxicity effects of the individual herb used in ‘five-seeds’ formulation and as a concoction on human HEK293 and Chang liver cells, using cell viability MTT assay and SubG1 flow cytometry analysis. Percentage of cell viability from samples (1, 25, 50, 75, 100 mg/mL) decreased as the concentration increased. Half maximal inhibitory concentration (IC50) values indicated that Cuscuta chinensis, Rubus idaeus and Schisandra chinensis are among the most toxic herb samples on HEK293 cells, with the IC50 values less than 22 mg/mL. On the other hand, Rubus idaeus (IC50 value 20.1 mg/mL) and Schisandra chinensis (IC50 value 17.8 mg/mL) were found to have the highest toxicity effect on Chang liver cells. Plantago asiatica and Lycium barbarum (IC50 more than 67 mg/mL) are the least toxic herbs tested on both human HEK293 kidney and Chang liver cells. ‘Five-seeds’ herbal formulation had IC50 values of 33 mg/mL and 38.5 mg/mL on HEK293 and Change liver cells respectively, suggesting that ‘five seeds’ formulation has modulated the toxicity effect of the mixed herbs used in this formula. Apoptotic cells in SubG1 phase were also found to be significantly low for HEK293 (13.08%) and Chang liver cells (10.17%) with the treatment of 25 mg/mL of ‘five seeds’ formulation. Toxicity effect of five-seeds’ herbal formulation has seemingly been modulated when all the five herbs mixed as a concoction, and potentially non-toxic as a concoction to HEK293 kidney and Chang liver cells. However, more investigations should be done to draw a solid conclusion.
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Ahmed Shawqy Saadoon, Mustafa Ghazi Alabbassi, and Nadia Hameed Mohammed. "Cuscuta Chinensis potentiate the effect of methotrexate in Rheumatoid Arthritis Induced Rats." Al Mustansiriyah Journal of Pharmaceutical Sciences 20, no. 4 (2022): 23–34. http://dx.doi.org/10.32947/ajps.v20i4.771.

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Background
 Rheumatoid arthritis (RA) is a chronic destructive inflammatory disease related to a breakdown in immune tolerance. This disease is characterized by joint inflammation, swelling, and in severe cases deformation may occur. Cuscuta
 Chinensis (C. Chinensis) is a parasitic plant, grow around other plants to absorb nutrient and water from them. C. Chinensis has a wide range of chemicals that produce a wide range of pharmacological activates. Because of its anti-oxidant and anti-inflammatory effect, it was considered as a good candidate to assess its role in RA.
 Methods:
 Rheumatoid arthritis was induced by injection of Complete Freund’s Adjuvant inside the foot-pad of male albino rats. The animals were grouped in four groups as follows group 1 considered as a normal control group, group 2 consider as positive control arthritis, group 3 treated with methotrexate (MTX), group 4 treated with MTX and C. Chinensis extract. On day 14 of immunization, treatments began and last for 21 days, at the end of the experiment all animals were sacrificed and serum was collected. The serum markers that had been evaluated were MMP3, VEGF, and SOD. Throughout the experiment time the body weight was evaluated.
 Results
 The combination significantly (P-value ≤ 0.05) improves objective parameter of RA which was the body weight. Also significantly decrease (P-value ≤ 0.05) the serum level of MMP3, VEGF, and considerably increase serum SOD.
 Conclusion:
 The combination has a significant beneficial role in suppression of destructive enzyme (MMP3), angiogenic stimulators (VEGF), and increase serum SOD enzyme.
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18

Liao, Jung-Chun, Wen-Te Chang, Meng-Shiou Lee, et al. "Antinociceptive and Anti-Inflammatory Activities ofCuscuta chinensisSeeds in Mice." American Journal of Chinese Medicine 42, no. 01 (2014): 223–42. http://dx.doi.org/10.1142/s0192415x14500153.

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The seeds of Cuscuta chinensis, Cuscutae Semen, are commonly used as a medicinal material for treating the aching and weakness of the loins and knees, tonifying the defects of the liver and the kidney, and treating the diarrhea due to hypofunction of the kidney and the spleen. Since aching and inflammation are highly correlated with such diseases, the aim of this study is to investigate the possible antinociceptive and anti-inflammatory mechanisms of the seeds of C. chinensis. The antinociceptive effect of the seeds of C. chinensis was evaluated via the acetic acid-induced writhing response and formalin-induced paw licking methods. The anti-inflammatory effect was evaluated via the λ-carrageenan induced mouse paw edema method. The results found that 100 and 500 mg/kg of the methanol extract of the seeds of C. chinensis( CCMeOH) significantly decreased (p < 0.01 and p < 0.001, respectively) the writhing response in the acetic acid assay. Additionally, 20–500 mg/kg of CCMeOHsignificantly decreased licking time at the early (20 and 100 mg/kg, p < 0.001) and late phases (100 mg/kg, p < 0.01; 500 mg/kg, p < 0.001) of the formalin test, respectively. Furthermore, CCMeOH(100 and 500 mg/kg) significantly decreased (p < 0.01 and p < 0.001, respectively) edema paw volume four hours after λ-carrageenan had been injected. The results in the following study also revealed that the anti-inflammatory mechanism of CCMeOHmay be due to declined levels of NO and MDA in the edema paw by increasing the activities of SOD, GPx and GRd in the liver. In addition, CCMeOHalso decreased IL-1β, IL-6, NF-κB, TNF-α, and COX-2 levels. This is the first study to demonstrate the possible mechanisms for the antinociceptive and anti-inflammatory effects of CCMeOHin vivo. Thus, it provides evidence for the treatment of Cuscutae Semen in inflammatory diseases.
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Shin, Sun, Yun Jung Lee, Eun Ju Kim, An Sook Lee, Dae Gill Kang, and Ho Sub Lee. "Effect of Cuscuta chinensis on Renal Function in Ischemia/Reperfusion-Induced Acute Renal Failure Rats." American Journal of Chinese Medicine 39, no. 05 (2011): 889–902. http://dx.doi.org/10.1142/s0192415x11009287.

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The kidneys play a central role in regulating water, ion composition and excretion of metabolic waste products in the urine. Cuscuta chinensis has been known as an important traditional Oriental medicine for the treatment of liver and kidney disorders. Thus, we studied whether an aqueous extract of Cuscuta chinensis (ACC) seeds has an effect on renal function parameters in ischemia/reperfusion-induced acute renal failure (ARF) rats. Administration of 250 mg/kg/day ACC showed that renal functional parameters including urinary excretion rate, osmolality, Na +, K +, Cl -, creatinine clearance, solute-free water reabsorption were significantly recovered in ischemia/reperfusion-induced ARF. Periodic acid Schiff staining showed that administration of ACC improved tubular damage in ischemia/reperfusion-induced ARF. In immunoblot and immunohistological examinations, ischemia/reperfusion-induced ARF decreased the expressions of water channel AQP 2, 3 and sodium potassium pump Na , K -ATPase in the renal medulla. However, administration of ACC markedly incremented AQP 2, 3 and Na , K -ATPase expressions. Therefore, these data indicate that administration of ACC ameliorates regulation of the urine concentration and renal functions in rats with ischemia/reperfusion-induced ARF.
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20

Sayed, Shimaa M. A., Saleh Alseekh, Karsten Siems, et al. "Identification of a Hydroxygallic Acid Derivative, Zingibroside R1 and a Sterol Lipid as Potential Active Ingredients of Cuscuta chinensis Extract That Has Neuroprotective and Antioxidant Effects in Aged Caenorhabditis elegans." Nutrients 14, no. 19 (2022): 4199. http://dx.doi.org/10.3390/nu14194199.

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We examined the effects of the extracts from two traditional Chinese medicine plants, Cuscuta chinensis and Eucommia ulmoides, on the healthspan of the model organism Caenorhabditis elegans. C. chinensis increased the short-term memory and the mechanosensory response of aged C. elegans. Furthermore, both extracts improved the resistance towards oxidative stress, and decreased the intracellular level of reactive oxygen species. Chemical analyses of the extracts revealed the presence of several bioactive compounds such as chlorogenic acid, cinnamic acid, and quercetin. A fraction from the C. chinensis extract enriched in zingibroside R1 improved the lifespan, the survival after heat stress, and the locomotion in a manner similar to the full C. chinensis extract. Thus, zingibroside R1 could be (partly) responsible for the observed health benefits of C. chinensis. Furthermore, a hydroxygallic acid derivative and the sterol lipid 4-alpha-formyl-stigmasta-7,24(241)-dien-3-beta-ol are abundantly present in the C. chinensis extract and its most bioactive fraction, but hardly in E. ulmoides, making them good candidates to explain the overall healthspan benefits of C. chinensis compared to the specific positive effects on stress resistance by E. ulmoides. Our findings highlight the overall anti-aging effects of C. chinensis in C. elegans and provide first hints about the components responsible for these effects.
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Dorjbat, Janchivmaa, Myagmarsuren Byambadolgor, Baatarkhuu Amarjargal, et al. "Evaluation of biological activity and toxicity of extracts from Cuscuta chinensis." Bulletin of the Institute of Chemistry and Chemical Technology, no. 9 (December 30, 2021): 40–46. http://dx.doi.org/10.5564/bicct.v4i9.1817.

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As the world's population grows, so do the many infectious and non-communicable diseases that follow, and there is an urgent need to find ways to treat and cure them. In particular, it is very important to study low-toxic, highly therapeutic substances from natural raw materials such as plants, animals and microorganisms and introduce them for use as medicines and food supplements. In our study, we studied the chemical composition of Cuscuta chinensis grown in Mongolia and obtained a group of extracts to determine the DPPH free radical inhibitory activity and calculated the IC50 value for hexane extract 32.09 μg/ml, chloroform extract 31.35 μg/ml, ethyl acetate extract 7.23 μg/ml, n-butanol extract 53.35 μg/ml, aqueous extract 84.46 μg/ml, and chloroform extract S.aureus, P.aeruginosa, B.subtilis, ethyl-acetate extract S.aureus, P.aeruginosa, B.subtilis, E.faecalis were active in inhibiting the growth of bacteria. Also evaluated toxicity of extracts for Brine shrimp lethality assay. Нангиад ороонго (Cuscuta chinensis Lam)-ын биологийн идэвх, хорон чанарын судалгаа Хураангуй: Бид судалгаандаа Монгол оронд ургадаг Нангиад ороонго /Cuscuta chinensis/-ын химийн найрлагыг судлан, бүлэг хандуудыг гарган авч, DPPH чөлөөт радикал саатуулах идэвхийг тодорхойлон IC50 утгыг тооцоход гексаны ханд 32.09 мкг/мл, хлороформын ханд 31.35 мкг/мл, этил-ацетатын ханд 7.23 мкг/мл, н-бутанолын ханд 53.35 мкг/мл, усан ханд 84.46 мкг/мл утгатай буюу бусад бүлэг хандаас этил-ацетатын ханд нь хамгийн өндөр идэвхтэй, бактерийн эсрэг идэвхийг тодорхойлоход хлороформын ханд Staphylococcus aureus, Pseudomonas aeruginosa, Bacillus subtilis, этил-ацетатын ханд S.aureus, P.aeruginosa, B.subtilis, Enterococcus faecalis бактериудын өсөлтийг дарангуйлах идэвхтэй байв. Мөн хорон чанарыг Artemia salina хавчийн авгалдайд 1 мг/мл, 100 мкг/мл, 10 мкг/мл, 1 мкг/мл концентрацтайгаар тодорхойлон, LC50 утгыг тооцож Кларксоны хорон чанарын индексээр үнэлэхэд н-бутанолын ханд 1619.4 мкг/мл, усан ханд 1888.5 мкг/мл буюу хоргүй, харин гексаны ханд 212.15 мкг/мл, хлороформын ханд 432.47 мкг/мл, этил-ацетатын ханд 455.55 мкг/мл буюу дунд зэргийн хортой байв.Түлхүүр үг: Brine shrimp, фенолт нэгдэл, флавоноид нэгдэл, шимэгч ургамал, ургамлын биохими.
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Tsai, Yu-Chi, Wan-Chun Lai, Ying-Chi Du, et al. "Lignan and Flavonoid Phytoestrogens from the Seeds of Cuscuta chinensis." Journal of Natural Products 75, no. 7 (2012): 1424. http://dx.doi.org/10.1021/np200974e.

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Fareed, Hafiz Muhammad, Lin Ma, Jiang Jianguo, Wu Jinghong, and Ali Murad Jakhar. "Allelopathic activity of Cuscuta chinensis against weed species." Journal of Biologically Active Products from Nature 15, no. 3 (2025): 316–26. https://doi.org/10.1080/22311866.2025.2523318.

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Yang, Shili, Huaiquan Liu, Kewei Li, et al. "Research in revealing the effects on Cuscuta chinensis to diarrhea type irritable bowel syndrome based on network pharmacology and molecular docking potential mechanism." Medicine 103, no. 19 (2024): e38113. http://dx.doi.org/10.1097/md.0000000000038113.

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To explore the potential mechanism in Cuscuta sinensis on diarrhea-type irritable bowel syndrome using network pharmacology and molecular docking techniques. First, the active components and related targets of Cuscuta were found setting oral utilization >30% and drug-like properties greater than or equal to 0.18 as filter information from TCMSP database. The targets of diarrheal irritable bowel syndrome were compiled by searching DrugBank, GeneCards, OMIM, PharmGkb, and TTD databases. The intersections of drugs and targets related to the disease were taken for gene ontology enrichment and Kyoto encyclopedia of genes and genomes enrichment analyses, to elucidate the potential molecular mechanisms and pathway information of Cuscuta sinensis for the treatment of diarrheal irritable bowel syndrome. The protein–protein interaction network was constructed by using the STRING database and visualized with Cytoscape_v3.10.0 software to find the protein–protein interaction network core At last, molecular docking was performed to validate the combination of active compounds with the core target. The target information of Cuscuta and diarrhea-type irritable bowel syndrome was compiled, which can be resulted in 11 active compounds such as quercetin, kaempferol, isorhamnetin, β-sitosterol, and another 17 core targets such as TP53, IL6, AKT1, IL1B, TNF, EGFR, etc, whose Kyoto encyclopedia of genes and genomes was enriched in the pathways of lipids and atherosclerosis, chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, and fluid shear stress and atherosclerosis, etc. Docking demonstrated that the core targets and the active compounds were able to be better combined. Cuscuta chinensis may exert preventive effects on diarrhea-type irritable bowel syndrome by reducing intestinal inflammation, protecting intestinal mucosa, and playing an important role in antioxidant response through multi-targets and multi-pathways.
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Cho, Jong-Won, and So-Yeon Jin. "Quality Characteristics of Yakju (Korean Traditional Rice Wine) Supplemented with Varying Amounts of Cuscuta Seed (Cuscuta chinensis Lamark)." Journal of the East Asian Society of Dietary Life 30, no. 6 (2020): 409–16. http://dx.doi.org/10.17495/easdl.2020.10.30.6.409.

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Yen, Feng-Lin, Tzu-Hui Wu, Liang-Tzung Lin, Thau-Ming Cham, and Chun-Ching Lin. "Nanoparticles formulation of Cuscuta chinensis prevents acetaminophen-induced hepatotoxicity in rats." Food and Chemical Toxicology 46, no. 5 (2008): 1771–77. http://dx.doi.org/10.1016/j.fct.2008.01.021.

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Shu, Jiao, Li Li, Hui Yu, and Dandan Zhang. "Fertility-enhancing potential of ethanol extract of Cuscuta chinensis seeds in a rat model of unilateral cryptorchidism." Tropical Journal of Pharmaceutical Research 20, no. 5 (2022): 995–1002. http://dx.doi.org/10.4314/tjpr.v20i5.16.

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 Purpose: To investigate the fertility-enhancing potential of the ethanol extract of Cuscuta chinensis seeds in a rat model of unilateral cryptorchidism (ULC), and the mechanism(s) of action.
 Methods: Healthy male Sprague Dawley rats (n = 48; mean weight = 220 ± 10 g) were randomly assigned to 4 groups (12 rats/group): control, ULC, 100 mg extract/kg and 200 mg extract/kg groups. Unilateral cryptorchidism of right testis was induced via standard method using an operating microscope. Rats in the treatment groups received 100 and 200 mg of ethanol extract of Cuscuta chinensis/kg orally once a day for 60 days. Sperm count and sperm motility were determined in seminal vesicular fluid (SVF) suspension. Oxidative stress markers and histological changes in rat testis were evaluated. The levels of caspase-3 and caspase-9 in testicular tissue were assessed by enzyme-linked immunosorbent assay (ELISA), while the protein expressions of Nrf2 and heme oxygenase 1 (HO-1) were determined using Western blotting.
 Results: Body and reproductive organ weights, sperm count, sperm motility, and activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) were significantly reduced in ULC group, relative to control group, but these parameters were significantly and dose-dependently increased following extract treatment (p < 0.05). Malondialdehyde (MDA), 8-hydroxy-2’-deoxyguanosine (8-OHdG), caspase-3 and caspase-9 levels were significantly higher in ULC group than in control group, but they were reduced significantly and dose-dependently after extract treatment (p < 0.05). Moreover, the protein expressions of Nrf2 and HO-1 were significantly downregulated in ULC group, when compared with control group, but they were significantly and dose-dependently upregulated by the extract (p < 0.05). Cross sections of testicular tissues of rats in ULC group revealed narrowed and thickened seminiferous tubules (disrupted spermatogonia) characterized by increased apoptotic bodies (increased number of necrotic Sertoli and Leydig cells). However, there were few damaged or necrotic Sertoli and Leydig cells, and complete absence of thickening of seminiferous tubules in testicular tissues of rats treated with the extract.
 Conclusion: The ethanol extract of Cuscuta chinensis seeds effectively mitigates cryptorchidism in rats via mechanisms involving the regulation of Nrf2/HO-1 signaling pathway, and inhibition of apoptosis and oxidative stress. Thus, the plant extract has potentials for further development for the management of male infertility
 
 
 
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Du, Xiao-Ming, Kyoko Kohinata (née Tsuji), Toshio Kawasaki, Yong-Tian Guo, and Kazumoto Miyahara. "Components of the ether-insoluble resin glycoside-like fraction from Cuscuta chinensis." Phytochemistry 48, no. 5 (1998): 843–50. http://dx.doi.org/10.1016/s0031-9422(97)00990-4.

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Fan, Bo-Yi, Jian-Guang Luo, Yu-Cheng Gu, and Ling-Yi Kong. "Unusual ether-type resin glycoside dimers from the seeds of Cuscuta chinensis." Tetrahedron 70, no. 11 (2014): 2003–14. http://dx.doi.org/10.1016/j.tet.2014.01.068.

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Qin, Daorui, Yunman Tang, Xuejun Wang, Yu Mao, and Zhichun Feng. "Antagonistic Effect of Cuscuta chinensis on a Rat Model with Unilateral Cryptorchidism." Medical Science Monitor 25 (September 7, 2019): 6727–35. http://dx.doi.org/10.12659/msm.916893.

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Sun, Kai, Chen Zhao, Xiang-Feng Chen, et al. "Ex vivo relaxation effect of Cuscuta chinensis extract on rabbit corpus cavernosum." Asian Journal of Andrology 15, no. 1 (2012): 134–37. http://dx.doi.org/10.1038/aja.2012.124.

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Maimaiti, Aikebaier, Li Jing-Jing, and Linsen Shi. "Investigating the acute and sub-acute toxicity of medicinal Cuscuta chinensis Lam plant." Journal of Ethnopharmacology 273 (June 2021): 114005. http://dx.doi.org/10.1016/j.jep.2021.114005.

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Chakraborty, Sumanta, Sunanda Burman, and Goutam Chandra. "Repellent and oviposition-deterrent efficacies of Cuscuta chinensis on filarial vector Culex quinquefasciatus." International Journal of Mosquito Research 9, no. 3 (2022): 48–52. http://dx.doi.org/10.22271/23487941.2022.v9.i3a.614.

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Yen, Feng-Lin, Tzu-Hui Wu, Liang-Tzung Lin, and Chun-Ching Lin. "Hepatoprotective and antioxidant effects of Cuscuta chinensis against acetaminophen-induced hepatotoxicity in rats." Journal of Ethnopharmacology 111, no. 1 (2007): 123–28. http://dx.doi.org/10.1016/j.jep.2006.11.003.

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Marambe, Buddhi, Siril Wijesundara, Kushan Tennakoon, Dhammika Pindeniya, and Chandana Jayasinghe. "Growth and development of Cuscuta chinensis Lam. and its impact on selected crops." Weed Biology and Management 2, no. 2 (2002): 79–83. http://dx.doi.org/10.1046/j.1445-6664.2002.00051.x.

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Jian-Hui, Liu, Jiang Bo, Bao Yong-Ming, and An Li-Jia. "Effect of Cuscuta chinensis glycoside on the neuronal differentiation of rat pheochromocytoma PC12 cells." International Journal of Developmental Neuroscience 21, no. 5 (2003): 277–81. http://dx.doi.org/10.1016/s0736-5748(03)00040-6.

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Wei, Ying-qin, Man-man Sun, and Hai-yan Fang. "Dienzyme-assisted salting-out extraction of flavonoids from the seeds of Cuscuta chinensis Lam." Industrial Crops and Products 127 (January 2019): 232–36. http://dx.doi.org/10.1016/j.indcrop.2018.10.068.

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Е.Ю., ЗЫКОВА. "ДОПОЛНЕНИЯ К ЧУЖЕРОДНОЙ ФЛОРЕ РЕСПУБЛИКИ АЛТАЙ". Растительный мир Азиатской России 17, № 2 (2024): 139–45. http://dx.doi.org/10.15372/rmar20240205.

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Сообщается о 5 видах, новых для чужеродной флоры Республики Алтай: Colchicum speciosum Steven, Cuscuta campestris Yunck., Lamium maculatum (L.) L., Phalaroides japonica Steud., Prunus cerasus L. Обнаружены новые местонахождения редко встречающихся в регионе видов: Amaranthus blitum L., Astragalus falcatus Lam., Callistephus chinensis (L.) Nees, Carduus acanthoides L., Euphorbia marginata Pursh, Ipomoea purpurea (L.) Roth., Picris hieracioides L., Reynoutria japonica Houtt., R. sachalinensis (F. Schmidt) Nakai, Rudbeckia hirta L., Stachys annua (L.) L. Для десяти чужеродных видов отмечено проникновение в новые для них муниципальные районы Республики Алтай, среди них Arctium minus (Hill) Bernh, Galinsoga parviflora Cav. и Lepidium ruderale L., являющиеся инвазионными видами в Республике Алтай. Особенности расселения в республике Amaranthus blitum, Carduus acanthoides, Portulaca oleracea L., Parthenocissus quinquefolia (L.) Planch., Reynoutria japonica Houtt., Rudbeckia laciniata L., Rumex obtusifolius L., Thladiantha dubia Bunge позволяют отнести их к потенциально инвазионным видам в регионе. Бóльшая часть обсуждаемых видов является ксенофитами, случайно занесенными видами. Five species new to the adventive flora of the Republic of Altai are reported: Colchicum speciosum Steven, Cuscuta campestris Yunck., Lamium maculatum (L.) L., Phalaroides japonica Steud., Prunus cerasus L. New locations of 11 species were discovered: Amaranthus blitum L., Astragalus falcatus Lam., Callistephus chinensis (L.) Nees, Carduus acanthoides L., Euphorbia marginata Pursh, Ipomoea purpurea (L.) Roth., Picris hieracioides L., Reynoutria japonica Houtt., R. sachalinensis (F. Schmidt) Nakai, Rudbeckia hirta L. and Stachys annua (L.) L., rare in the region. For 10 alien species, penetration into new areas was noted, among them Arctium minus (Hill) Bernh, Galinsoga parviflora Cav. and Lepidium ruderale L., which are invasive species in the Republic of Altai. Features of the settlement in the republic of Amaranthus blitum L., Carduus acanthoides L., Portulaca oleracea L., Parthenocissus quinquefolia (L.) Planch., Reynoutria japonica Houtt., Rudbeckia laciniata L., Rumex obtusifolius L., Thladiantha dubia Bunge allow them to be classified as potentially invasive species in the region. Most of the species discussed are xenophytes, accidentally introduced species.
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Pan, Shaobin, Xiao Wang, Wenjuan Duan, Zongyuan Yu, Lin Zhang, and Wei Liu. "PREPARATIVE ISOLATION AND PURIFICATION OF FLAVONOIDS FROM CUSCUTA CHINENSIS LAM. BY HIGH-SPEED COUNTERCURRENT CHROMATOGRAPHY." Journal of Liquid Chromatography & Related Technologies 37, no. 15 (2014): 2162–71. http://dx.doi.org/10.1080/10826076.2013.825869.

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Bao, Xingfeng, Zhan Wang, Jinian Fang, and Xiaoyu Li. "Structural Features of an Immunostimulating and Antioxidant Acidic Polysaccharide from the Seeds of Cuscuta chinensis." Planta Medica 68, no. 3 (2002): 237–43. http://dx.doi.org/10.1055/s-2002-23133.

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Yen, Feng-Lin, Tzu-Hui Wu, Liang-Tzung Lin, Thau-Ming Cham, and Chun-Ching Lin. "Concordance between antioxidant activities and flavonol contents in different extracts and fractions of Cuscuta chinensis." Food Chemistry 108, no. 2 (2008): 455–62. http://dx.doi.org/10.1016/j.foodchem.2007.10.077.

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Alijaniha, Fatemeh, Fatemeh Emadi, Mohsen Naseri, and Zahra Bahaedin. "Preliminary Phytochemical and Physicochemical Study of Cuscuta Chinensis L. Aqueous Extract Compared with Previous Studies." complementary Medicine Journal 13, no. 1 (2023): 3–9. http://dx.doi.org/10.61186/cmja.13.1.3.

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Pan, Hangkai, Yi Li, Luxi Chen, and Junmin Li. "Molecular Processes of Dodder Haustorium Formation on Host Plant under Low Red/Far Red (R/FR) Irradiation." International Journal of Molecular Sciences 23, no. 14 (2022): 7528. http://dx.doi.org/10.3390/ijms23147528.

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Low R/FR irradiation can promote dodder haustorium formation on the host plant; however, the mechanisms underlying the process are still unknown. In this study, we compared the transcriptomic data during the formation of haustorium of Cuscuta chinensis on host plant Arabidopsisthaliana under low (R/FR = 0.1) versus high (R/FR = 0.2) R/FR irradiation at 12 h, 24 h and 72 h time points. The results show that low R/FR radiation significantly promoted the entanglement and haustorium formation. Transcriptome analysis showed that during the early stage of haustorium formation, low R/FR radiation significantly up-regulated ARR-A related genes and down-regulated peroxidase related genes compared with high R/FR radiation. Meanwhile, during the middle stage of haustorium formation, low R/FR treatment significantly increased the expression of genes related to pectinesterase (PE), polygalacturonase (PG) and pectin lyase (Pel) production, while, during the late stage of haustorium formation, peroxidase (Prx)-related genes were differentially expressed under different R/FR treatments. Overall, our findings show that a low R/FR ratio promotes the parasitism of C. chinensis through plant hormone signal transduction and cell wall degradation pathways. This study provides a basis for the control of parasitic plants.
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Yang, Cheng-Chan, Jia-Ying Chien, Yu-Yau Chou, Jhih-Wei Ciou, and Shun-Ping Huang. "The Effects of Lycium chinense, Cuscuta chinensis, Senna tora, Ophiopogon japonicus, and Dendrobium nobile Decoction on a Dry Eye Mouse Model." Medicina 58, no. 8 (2022): 1134. http://dx.doi.org/10.3390/medicina58081134.

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Background and objective: Dry eye disease (DED) is a relatively common disorder associated with abnormal tear film and the ocular surface that causes ocular irritation, dryness, visual impairment, and damage to the cornea. DED is not a life-threatening disease but causes discomfort and multifactorial disorders in vision that affect daily life. It has been reported that all traditional medicinal plants exhibit anti-inflammatory effects on several diseases. We hypothesized that the decoction ameliorated ocular irritation and decreased cytokine expression in the cornea. This study aimed to investigate the molecular mechanisms of DED and discover a therapeutic strategy to reduce corneal inflammation. Material and Methods: We used a DED mouse model with extraorbital lacrimal gland (ELG) excision and treated the mice with a decoction of five traditional medicines: Lycium chinense, Cuscuta chinensis, Senna tora, Ophiopogon japonicus, and Dendrobium nobile for 3 months. The tear osmolarity and the ocular surface staining were evaluated as indicators of DED. Immunohistochemistry was used to detect the level of inflammation on the cornea. Results: After treatment with the decoction for three months, epithelial erosions and desquamation were reduced, the intact of corneal endothelium was maintained, and tear osmolarity was restored in the eyes. The IL-1β-associated inflammatory response was reduced in the cornea in the DED model. Conclusions: These data suggested that a mixture of traditional medicines might be a novel therapy to treat DED.
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Kim, Suji, Byung-Hyun Jang, Seo-Hyuk Chang, et al. "Effects of Herbal Mixture Extracts Containing Angelica gigas Nakai and Cuscuta chinensis Lam. on Menopausal Symptoms in Ovariectomized Rats." Journal of the Korean Society of Food Science and Nutrition 45, no. 8 (2016): 1083–89. http://dx.doi.org/10.3746/jkfn.2016.45.8.1083.

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Alijaniha, Fatemeh, Fatemeh Emadi, Mohsen Naseri, et al. "Effect of gamma irradiation on cytotoxicity, phenolics content and acute toxicity of Cuscuta chinensis L. extract." Radiation Physics and Chemistry 185 (August 2021): 109508. http://dx.doi.org/10.1016/j.radphyschem.2021.109508.

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Chakraborty, Sumanta, and Goutam Chandra. "Eco-Friendly Larvicidal Compounds from Cuscuta chinensis Seed Extract against Culex quinquefasciatus without Non-Target Toxicity." Proceedings of the Zoological Society 75, no. 1 (2022): 94–102. http://dx.doi.org/10.1007/s12595-021-00427-w.

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LAI, Xiaojian, Shixi CHEN, Guoyin LAI, et al. "Chinese herbs Epimedium brevicornum Maxim. and Cuscuta chinensis Lam. induced ovary development in Japanese eel Anguilla japonica." Journal of Fishery Sciences of China 26, no. 2 (2019): 314. http://dx.doi.org/10.3724/sp.j.1118.2019.18173.

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Salih, S., T. Alkhazraji, and A. Ali. "ALKALOID CONTENT AND EFFECTIVENESS OF ANTI-BACTERIAL AND OXIDATION EXTRACTS OF THE SPECIES Cuscuta chinensis Lam. (CONVOLVULACEAE)." Journal of Plant Production 7, no. 2 (2016): 117–22. http://dx.doi.org/10.21608/jpp.2016.44281.

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Zhu, Ronghua, Feng Liu, Wei Liu, Shuqin Zhang, Xiao Wang, and Luqi Huang. "Determination of Four Flavonoids in Cuscuta chinensis Lam. by HPLC with Ultrahigh Pressure-Assisted Cloud Point Extraction." Asian Journal of Chemistry 26, no. 16 (2014): 5058–62. http://dx.doi.org/10.14233/ajchem.2014.16318.

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