Academic literature on the topic 'DEHP metabolites, mono-(2-ethylhexyl)phthalate (MEHP)'

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Journal articles on the topic "DEHP metabolites, mono-(2-ethylhexyl)phthalate (MEHP)"

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Beg, Mohd Amin, and Ishfaq Ahmad Sheikh. "Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites." Toxics 8, no. 4 (2020): 115. http://dx.doi.org/10.3390/toxics8040115.

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Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chloride plastics for household and commercial use. DEHP is a ubiquitous ecocontaminant and causes developmental and reproductive problems in children and adults. After exposure, DEHP is metabolized by endogenous hydrolysis and oxidation into the primary metabolite, mono-(2-ethylhexyl) phthalate (MEHP), and the secondary metabolites, mono-(2-ethyl-5-hydroxhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (5-cx-MEPP), and mono-[(2-car
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Kambia, Nicolas, Isabelle Séverin, Amaury Farce, et al. "Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies." Metabolites 11, no. 2 (2021): 94. http://dx.doi.org/10.3390/metabo11020094.

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Plasticizers added to polyvinylchloride (PVC) used in medical devices can be released into patients’ biological fluids. Di-(2-ethylhexyl)phthalate (DEHP), a well-known reprotoxic and endocrine disruptor, must be replaced by alternative compounds. Di-(2-ethylhexyl) terephthalate (DEHT) is an interesting candidate due to its lower migration from PVC and its lack of reprotoxicity. However, there is still a lack of data to support the safety of its human metabolites with regard to their hormonal properties in the thyroid system. The effects of DEHT metabolites on thyroid/hormone receptors (TRs) we
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Sun, Xinyi, Wenqiong Chen, Shiqi Weng, et al. "Effects of the environmental endocrine disruptors di-2-ethylhexyl phthalate and mono-2-ethylhexyl phthalate on human sperm function in vitro." Reproduction, Fertility and Development 32, no. 6 (2020): 629. http://dx.doi.org/10.1071/rd19164.

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Di-2-ethylhexyl phthalate (DEHP), a plastic-derived, endocrine-disrupting chemical, has been shown to exhibit male reproductive toxicity. However, its effects on human mature spermatozoa are largely unknown. In this study we investigated the invitro effects of DEHP and mono-2-ethylhexyl phthalate (MEHP; the main metabolite of DEHP) on sperm function and the mechanisms involved. Human spermatozoa were exposed to phthalates invitro at the doses that cover the concentrations detected in human semen: 20nM–8 μM DEHP, 1nM–20 μM MEHP or a mixture of 20nM–8 μM DEHP and 1nM–20 μM MEHP. DEHP and MEHP, a
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Genuis, Stephen J., Sanjay Beesoon, Rebecca A. Lobo, and Detlef Birkholz. "Human Elimination of Phthalate Compounds: Blood, Urine, and Sweat (BUS) Study." Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/615068.

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Background. Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro. Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion.Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy par
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Fan, Shuanghu, Junhuan Wang, Yanchun Yan, Jiayi Wang, and Yang Jia. "Excellent Degradation Performance of a Versatile Phthalic Acid Esters-Degrading Bacterium and Catalytic Mechanism of Monoalkyl Phthalate Hydrolase." International Journal of Molecular Sciences 19, no. 9 (2018): 2803. http://dx.doi.org/10.3390/ijms19092803.

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Despites lots of characterized microorganisms that are capable of degrading phthalic acid esters (PAEs), there are few isolated strains with high activity towards PAEs under a broad range of environmental conditions. In this study, Gordonia sp. YC-JH1 had advantages over its counterparts in terms of di(2-ethylhexyl) phthalate (DEHP) degradation performance. It possessed an excellent degradation ability in the range of 20–50 °C, pH 5.0–12.0, or 0–8% NaCl with the optimal degradation condition 40 °C and pH 10.0. Therefore, strain YC-JH1 appeared suitable for bioremediation application at various
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Tranfo, Giovanna, Lidia Caporossi, Daniela Pigini, Silvia Capanna, Bruno Papaleo, and Enrico Paci. "Temporal Trends of Urinary Phthalate Concentrations in Two Populations: Effects of REACH Authorization after Five Years." International Journal of Environmental Research and Public Health 15, no. 9 (2018): 1950. http://dx.doi.org/10.3390/ijerph15091950.

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Phthalates are widely used in the industrial manufacture of many products. Some phthalates have shown reproductive toxicity in humans, acting as endocrine disruptors, so they were included in the authorization process defined in Reg. CE 1907/2006 (REACH). Two groups of population were recruited, before and after the inclusion of some phthalates in the authorization list in REACH: the first group of 157 volunteers was studied in 2011 and the second, 171 volunteers, in 2016. Each subject completed a questionnaire about personal lifestyle, working activities and use of chemical products. The main
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Hung, Shen-Che, Ting-I. Lin, Jau-Ling Suen, et al. "Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan." International Journal of Environmental Research and Public Health 18, no. 11 (2021): 5726. http://dx.doi.org/10.3390/ijerph18115726.

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Di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, has been detected in breast milk in many countries; however, whether phthalate metabolite concentration and the detection rate in breast milk change postpartum is still unknown. We measured phthalate metabolite concentrations in breast milk in the first 6 months postpartum in women enrolled in the E-Da hospital from January to July 2017. A total of 56 breastfeeding mothers and 66 samples were included in this study. We analyzed the samples’ concentration of eight phthalate metabolites using liquid chromatography mass spectrometry. The c
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Kolena, Branislav, Ida Petrovicova, Miroslava Sidlovska, et al. "Phthalates Exposure and Occupational Symptoms among Slovakian Hairdressing Apprentices." Applied Sciences 9, no. 16 (2019): 3321. http://dx.doi.org/10.3390/app9163321.

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The objectives of the study were to examine occupational exposure to phthalates of hairdressing apprentices from Slovakia (n = 74, 89.2% females; 10.8% males), outcomes related to body composition and pulmonary functions. We used high-performance liquid chromatography and tandem mass spectrometry to the quantified urinary concentration of phthalates. Pulmonary function test (PFT), anthropometric measurements, and questionnaire were also conducted. We observed a decrease of % of predicted values of forced vital capacity (FVC% of PV) related exposure to mono(2-ethyl-5-oxohexyl) phthalate (MEOHP;
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Gunnarsson, David, Per Leffler, Emelie Ekwurtzel, Gunilla Martinsson, Kui Liu, and Gunnar Selstam. "Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes." REPRODUCTION 135, no. 5 (2008): 693–703. http://dx.doi.org/10.1530/rep-07-0460.

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Phthalates are widely used as plasticizers in a number of daily-life products. In this study, we investigated the influence of mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of the frequently used plasticizer di-(2-ethylhexyl) phthalate (DEHP), on gonadal steroidogenesisin vitro. MEHP (25–100 μM) stimulated basal steroid synthesis in a concentration-dependent manner in immortalized mouse Leydig tumor cells (MLTC-1). The stimulatory effect was also detected in KK-1 granulosa tumor cells. MEHP exposure did not influence cAMP or StAR protein levels and induced a gene expression profi
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KASAHARA, Emiko, Eisuke F. SATO, Mami MIYOSHI, et al. "Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate." Biochemical Journal 365, no. 3 (2002): 849–56. http://dx.doi.org/10.1042/bj20020254.

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Phthalate esters have been used extensively as plasticizers of synthetic polymers. Recent studies have revealed that these esters induce atrophy of the testis, although its pathogenesis remains unknown. The present study describes the possible involvement of oxidative stress in the pathogenesis of atrophy of the rat testis induced by di(2-ethylhexyl)phthalate (DEHP). Biochemical and immunohistochemical analysis revealed that oral administration of DEHP increased the generation of reactive oxygen species, with concomitant decrease in the concentration of glutathione and ascorbic acid in the tes
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Dissertations / Theses on the topic "DEHP metabolites, mono-(2-ethylhexyl)phthalate (MEHP)"

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Monfort, Mercader Núria 1983. "Detecció dels metabòlits del plastificant di(2-etilhexi)l ftalat com a marcadors de l'ús de transfusions en l'esport." Doctoral thesis, Universitat Pompeu Fabra, 2012. http://hdl.handle.net/10803/110464.

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El di(2-etilhexil) ftalat (DEHP) és un plastificant que s’afegeix als productes de clorur de polivinil (PVC) per a dotar-los de més flexibilitat. El material mèdic fet de PVC, i en particular els dispositius i bosses que s’utilitzen en les transfusions de sang, conté el DEHP com additiu. Així, el receptor d’una transfusió està altament exposat a aquest compost. L’objectiu de la tesi va ser estudiar els metabòlits del DEHP en orina com a possibles marcadors de la pràctica d’una transfusió de sang en l’esport. Es va desenvolupar i validar un mètode d’anàlisi per cromatografia líquida acoblada a
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Zurek, Martin [Verfasser]. "Wirkungen der Phthalate DEHP [Di-(2-ethylhexyl)-phthalat] und MEHP [Mono-(2-ethylhexyl)-phthalat] und des Schwermetalls Cadmium auf die Zellen der Sertoli-Zelllinie SerW3 / Martin Zurek." Berlin : Medizinische Fakultät Charité - Universitätsmedizin Berlin, 2011. http://d-nb.info/1026264774/34.

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Conference papers on the topic "DEHP metabolites, mono-(2-ethylhexyl)phthalate (MEHP)"

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Labow, R. S., E. Meek, G. A. Adams, and G. Rock. "AGGREGATION RESPONSE OF PLATELETS DURING INHIBITION OF PHOSPHOLIPASE A2." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644542.

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Arachidonic acid (AA) is liberated from platelet membrane phospholipids during stimulation and promotes cellular aggregation through the synthesis of thromboxane A2. Two pathways; phospholipase A2 (PLA2) or phospholipase C (PLC) followed by the action of acylglycerolipases, are thought to be activated during platelet stimulation and supply the necessary AA. We have reported that mono (2-ethylhexyl)phthalate (MEHP), a physiological metabolite of the plasticizer di(2-ethylhexyl)-phthalate (DEHP), commonly used in a variety of medical devices and storage containers, inhibits PLA2, but not PLC in
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