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Journal articles on the topic 'DEHP metabolites, mono-(2-ethylhexyl)phthalate (MEHP)'

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Published: 4 June 2021

Last updated: 18 February 2022

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1

Beg, Mohd Amin, and Ishfaq Ahmad Sheikh. "Endocrine Disruption: Structural Interactions of Androgen Receptor against Di(2-ethylhexyl) Phthalate and Its Metabolites." Toxics 8, no. 4 (2020): 115. http://dx.doi.org/10.3390/toxics8040115.

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Diethylhexyl phthalate (DEHP) is a commonly used plasticizer in the manufacture of polyvinyl chloride plastics for household and commercial use. DEHP is a ubiquitous ecocontaminant and causes developmental and reproductive problems in children and adults. After exposure, DEHP is metabolized by endogenous hydrolysis and oxidation into the primary metabolite, mono-(2-ethylhexyl) phthalate (MEHP), and the secondary metabolites, mono-(2-ethyl-5-hydroxhexyl)phthalate (5-OH-MEHP), mono-(2-ethyl-5-oxohexyl) phthalate (5-oxo-MEHP), mono-(2-ethyl-5-carboxypentyl) phthalate (5-cx-MEPP), and mono-[(2-car

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2

Kambia, Nicolas, Isabelle Séverin, Amaury Farce, et al. "Comparative Effects of Di-(2-ethylhexyl)phthalate and Di-(2-ethylhexyl)terephthalate Metabolites on Thyroid Receptors: In Vitro and In Silico Studies." Metabolites 11, no. 2 (2021): 94. http://dx.doi.org/10.3390/metabo11020094.

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Plasticizers added to polyvinylchloride (PVC) used in medical devices can be released into patients’ biological fluids. Di-(2-ethylhexyl)phthalate (DEHP), a well-known reprotoxic and endocrine disruptor, must be replaced by alternative compounds. Di-(2-ethylhexyl) terephthalate (DEHT) is an interesting candidate due to its lower migration from PVC and its lack of reprotoxicity. However, there is still a lack of data to support the safety of its human metabolites with regard to their hormonal properties in the thyroid system. The effects of DEHT metabolites on thyroid/hormone receptors (TRs) we

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3

Sun, Xinyi, Wenqiong Chen, Shiqi Weng, et al. "Effects of the environmental endocrine disruptors di-2-ethylhexyl phthalate and mono-2-ethylhexyl phthalate on human sperm function in vitro." Reproduction, Fertility and Development 32, no. 6 (2020): 629. http://dx.doi.org/10.1071/rd19164.

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Di-2-ethylhexyl phthalate (DEHP), a plastic-derived, endocrine-disrupting chemical, has been shown to exhibit male reproductive toxicity. However, its effects on human mature spermatozoa are largely unknown. In this study we investigated the invitro effects of DEHP and mono-2-ethylhexyl phthalate (MEHP; the main metabolite of DEHP) on sperm function and the mechanisms involved. Human spermatozoa were exposed to phthalates invitro at the doses that cover the concentrations detected in human semen: 20nM–8 μM DEHP, 1nM–20 μM MEHP or a mixture of 20nM–8 μM DEHP and 1nM–20 μM MEHP. DEHP and MEHP, a

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4

Genuis, Stephen J., Sanjay Beesoon, Rebecca A. Lobo, and Detlef Birkholz. "Human Elimination of Phthalate Compounds: Blood, Urine, and Sweat (BUS) Study." Scientific World Journal 2012 (2012): 1–10. http://dx.doi.org/10.1100/2012/615068.

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Background. Individual members of the phthalate family of chemical compounds are components of innumerable everyday consumer products, resulting in a high exposure scenario for some individuals and population groups. Multiple epidemiological studies have demonstrated statistically significant exposure-disease relationships involving phthalates and toxicological studies have shown estrogenic effects in vitro. Data is lacking in the medical literature, however, on effective means to facilitate phthalate excretion.Methods. Blood, urine, and sweat were collected from 20 individuals (10 healthy par

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Fan, Shuanghu, Junhuan Wang, Yanchun Yan, Jiayi Wang, and Yang Jia. "Excellent Degradation Performance of a Versatile Phthalic Acid Esters-Degrading Bacterium and Catalytic Mechanism of Monoalkyl Phthalate Hydrolase." International Journal of Molecular Sciences 19, no. 9 (2018): 2803. http://dx.doi.org/10.3390/ijms19092803.

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Despites lots of characterized microorganisms that are capable of degrading phthalic acid esters (PAEs), there are few isolated strains with high activity towards PAEs under a broad range of environmental conditions. In this study, Gordonia sp. YC-JH1 had advantages over its counterparts in terms of di(2-ethylhexyl) phthalate (DEHP) degradation performance. It possessed an excellent degradation ability in the range of 20–50 °C, pH 5.0–12.0, or 0–8% NaCl with the optimal degradation condition 40 °C and pH 10.0. Therefore, strain YC-JH1 appeared suitable for bioremediation application at various

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Tranfo, Giovanna, Lidia Caporossi, Daniela Pigini, Silvia Capanna, Bruno Papaleo, and Enrico Paci. "Temporal Trends of Urinary Phthalate Concentrations in Two Populations: Effects of REACH Authorization after Five Years." International Journal of Environmental Research and Public Health 15, no. 9 (2018): 1950. http://dx.doi.org/10.3390/ijerph15091950.

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Phthalates are widely used in the industrial manufacture of many products. Some phthalates have shown reproductive toxicity in humans, acting as endocrine disruptors, so they were included in the authorization process defined in Reg. CE 1907/2006 (REACH). Two groups of population were recruited, before and after the inclusion of some phthalates in the authorization list in REACH: the first group of 157 volunteers was studied in 2011 and the second, 171 volunteers, in 2016. Each subject completed a questionnaire about personal lifestyle, working activities and use of chemical products. The main

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7

Hung, Shen-Che, Ting-I. Lin, Jau-Ling Suen, et al. "Phthalate Exposure Pattern in Breast Milk within a Six-Month Postpartum Time in Southern Taiwan." International Journal of Environmental Research and Public Health 18, no. 11 (2021): 5726. http://dx.doi.org/10.3390/ijerph18115726.

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Di-(2-ethylhexyl) phthalate (DEHP), a common plasticizer, has been detected in breast milk in many countries; however, whether phthalate metabolite concentration and the detection rate in breast milk change postpartum is still unknown. We measured phthalate metabolite concentrations in breast milk in the first 6 months postpartum in women enrolled in the E-Da hospital from January to July 2017. A total of 56 breastfeeding mothers and 66 samples were included in this study. We analyzed the samples’ concentration of eight phthalate metabolites using liquid chromatography mass spectrometry. The c

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8

Kolena, Branislav, Ida Petrovicova, Miroslava Sidlovska, et al. "Phthalates Exposure and Occupational Symptoms among Slovakian Hairdressing Apprentices." Applied Sciences 9, no. 16 (2019): 3321. http://dx.doi.org/10.3390/app9163321.

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The objectives of the study were to examine occupational exposure to phthalates of hairdressing apprentices from Slovakia (n = 74, 89.2% females; 10.8% males), outcomes related to body composition and pulmonary functions. We used high-performance liquid chromatography and tandem mass spectrometry to the quantified urinary concentration of phthalates. Pulmonary function test (PFT), anthropometric measurements, and questionnaire were also conducted. We observed a decrease of % of predicted values of forced vital capacity (FVC% of PV) related exposure to mono(2-ethyl-5-oxohexyl) phthalate (MEOHP;

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Gunnarsson, David, Per Leffler, Emelie Ekwurtzel, Gunilla Martinsson, Kui Liu, and Gunnar Selstam. "Mono-(2-ethylhexyl) phthalate stimulates basal steroidogenesis by a cAMP-independent mechanism in mouse gonadal cells of both sexes." REPRODUCTION 135, no. 5 (2008): 693–703. http://dx.doi.org/10.1530/rep-07-0460.

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Phthalates are widely used as plasticizers in a number of daily-life products. In this study, we investigated the influence of mono-(2-ethylhexyl) phthalate (MEHP), the active metabolite of the frequently used plasticizer di-(2-ethylhexyl) phthalate (DEHP), on gonadal steroidogenesisin vitro. MEHP (25–100 μM) stimulated basal steroid synthesis in a concentration-dependent manner in immortalized mouse Leydig tumor cells (MLTC-1). The stimulatory effect was also detected in KK-1 granulosa tumor cells. MEHP exposure did not influence cAMP or StAR protein levels and induced a gene expression profi

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KASAHARA, Emiko, Eisuke F. SATO, Mami MIYOSHI, et al. "Role of oxidative stress in germ cell apoptosis induced by di(2-ethylhexyl)phthalate." Biochemical Journal 365, no. 3 (2002): 849–56. http://dx.doi.org/10.1042/bj20020254.

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Phthalate esters have been used extensively as plasticizers of synthetic polymers. Recent studies have revealed that these esters induce atrophy of the testis, although its pathogenesis remains unknown. The present study describes the possible involvement of oxidative stress in the pathogenesis of atrophy of the rat testis induced by di(2-ethylhexyl)phthalate (DEHP). Biochemical and immunohistochemical analysis revealed that oral administration of DEHP increased the generation of reactive oxygen species, with concomitant decrease in the concentration of glutathione and ascorbic acid in the tes

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Rothenbacher, Klaus-Peter, Reiner Kimmel, Sibylle Hildenbrand, Friedrich W. Schmahl, and Peter C. Dartsch. "Nephrotoxic effects of di-(2-ethylhexyl)phthalate (DEHP) hydrolysis products on cultured kidney epithelial cells." Human & Experimental Toxicology 17, no. 6 (1998): 336–42. http://dx.doi.org/10.1177/096032719801700609.

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1 Di-(2-ethylhexyl)-phthalate (DEHP) possesses a great industrial value as a plasticizing agent and has become an ubiquitous environmental contaminant. In most species it is rapidly metabolized to mono-(2-ethylhexyl)-phthalate (MEHP) and 2-ethylhexanoic acid (2- EHA). Evaluation of toxicity of DEHP and its primary metabolites has been focussed on reproductive toxicity and hepatocarcinogenic properties. The aim of this study was to determine the nephrotoxic potential of both DEHP metabolites by use of cultured kidney epithelial cells (Opossum kidney cells; OK cells). 2 For this purpose, OK cell

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Mettang, Thomas, Christiane Pauli–Magnus, Dominik Mark Alscher, et al. "Influence of Plasticizer-Free CAPD Bags and Tubings on Serum, Urine, and Dialysate Levels of Phthalic Acid Esters in CAPD Patients." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 20, no. 1 (2000): 80–84. http://dx.doi.org/10.1177/089686080002000115.

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Objectives To evaluate the impact of a plasticizer-free device on exposure to di-(2-ethylhexyl) phthalate (DEHP) and its major metabolites in patients on continuous ambulatory peritoneal dialysis (CAPD). DEHP is the most commonly used plasticizer in polyvinyl chloride (PVC) products; it is added to CAPD bags in order to improve the flexibility of the material. Since DEHP leaches out of the plastic matrix, patients on CAPD are exposed to considerable amounts of DEHP and its metabolites. Design A prospective cross-over study. Setting Department of nephrology in a teaching hospital. Participants

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Martínez-Ibarra, Alejandra, Luis Daniel Martínez-Razo, Edgar Ricardo Vázquez-Martínez, et al. "Unhealthy Levels of Phthalates and Bisphenol A in Mexican Pregnant Women with Gestational Diabetes and Its Association to Altered Expression of miRNAs Involved with Metabolic Disease." International Journal of Molecular Sciences 20, no. 13 (2019): 3343. http://dx.doi.org/10.3390/ijms20133343.

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Several studies indicate that bisphenol A (BPA) and phthalates may have a role in the development of metabolic diseases using different molecular pathways, including epigenetic regulatory mechanisms. However, it is unclear whether exposure to these chemicals modifies serum levels of miRNAs associated with gestational diabetes mellitus (GDM) risk. In the present study, we evaluated the serum levels of miRNAs associated with GDM (miR-9-5p, miR-16-5p, miR-29a-3p and miR-330-3p) and urinary levels of phthalate metabolites (mono-n-butyl phthalate (MBP), mono-isobutyl phthalate (MiBP), mono-benzyl p

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14

Shi, L., L. Jiang, X. Zhang, et al. "Pyrroloquinoline quinone protected autophagy-dependent apoptosis induced by mono(2-ethylhexyl) phthalate in INS-1 cells." Human & Experimental Toxicology 39, no. 2 (2019): 194–211. http://dx.doi.org/10.1177/0960327119882983.

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Mono(2-ethylhexyl) phthalate (MEHP) is the main metabolite of di(2-ethylhexyl) phthalate (DEHP) in organisms and is commonly used as a plasticizer. Exposure to DEHP impairs the function of islet beta cells (INS-1 cells), which is related to insulin resistance and type 2 diabetes. At present, some research data have also confirmed that MEHP has a certain damage effect on INS-1 cells. In our experiment, we found that MEHP would lead to the increase of reactive oxygen species (ROS) and the upregulation of autophagy. And downregulated ROS production by N-acetyl-L-cysteine could also reduce autopha

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15

Kim, Hongsoo, Seyune Lee, Young-Il Jung, and Yun-Chul Hong. "Association between Phthalate Exposure and Frailty among Community-Dwelling Older Adults: A Repeated Panel Data Study." International Journal of Environmental Research and Public Health 18, no. 4 (2021): 1985. http://dx.doi.org/10.3390/ijerph18041985.

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Only a few studies have examined the impacts of environmental exposure on frailty. This study investigated the association between phthalates and frailty among community-dwelling older adults. The Korean Elderly Environmental Panel II (KEEP II) study is a repeated panel data study of 800 community-dwelling older adults in South Korea. Frailty was measured with five items defined by Fried and colleagues. Environmental pollutants in the form of two types of metabolites for Di-ethylhexyl phthalate (DEHPs)—Mono (2-ethyl-5-hydroxyhexyl) phthalate (MEHHP) and Mono (2-ethyl-5-oxohexyl) phthalate (MEO

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Hildenbrand, Sibylle, Thomas Gabrio, and Gerhard Volland. "Inter-Day Variability of Metabolites of DEHP and DnBP in Human Urine—Comparability of the Results of Longitudinal Studies with a Cross-Sectional Study." International Journal of Environmental Research and Public Health 16, no. 6 (2019): 1029. http://dx.doi.org/10.3390/ijerph16061029.

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In the current paper, we compare the inter-day variability of the metabolite concentration of di(2-ethylhexyl) phthalate (DEHP) and di-n-butyl phthalate (DnBP) in 247 morning urine samples obtained from 19 probands of different age and sex with the metabolite concentration in morning urine obtained from 215 probands of the “Tübingen Survey” cross-sectional study. In the first longitudinal study the morning urine of seven volunteers was collected four times a year for seven consecutive days (course of the year study). In a second study the morning urine of 12 students of a boarding school was c

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Hao, Chanjuan, Xuejia Cheng, Hongfei Xia, and Xu Ma. "The endocrine disruptor mono-(2-ethylhexyl)phthalate promotes adipocyte differentiation and induces obesity in mice." Bioscience Reports 32, no. 6 (2012): 619–29. http://dx.doi.org/10.1042/bsr20120042.

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The environmental obesogen hypothesis proposes that exposure to endocrine disruptors during developmental ‘window’ contributes to adipogenesis and the development of obesity. MEHP [mono-(2-ethylhexyl) phthalate], a metabolite of the widespread plasticizer DEHP [di-(2-ethylhexyl) phthalate], has been found in exposed organisms and identified as a selective PPARγ (peroxisome-proliferator-activated receptor γ) modulator. However, implication of MEHP on adipose tissue development has been poorly investigated. In the present study, we show the dose-dependent effects of MEHP on adipocyte differentia

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Awal, M. A., M. Kurohmaru, M. Ishii, B. B. Andriana, Y. Kanai, and Y. Hayashi. "Mono-(2-ethylhexyl) Phthalate (MEHP) Induces Spermatogenic Cell Apoptosis in Guinea Pig Testes at Prepubertal Stage In Vitro." International Journal of Toxicology 23, no. 6 (2004): 349–55. http://dx.doi.org/10.1080/10915810490901985.

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The effects of mono-(2-ethylhexyl) phthalate (MEHP), an active metabolite of di-(2-ethylhexyl) phthalate (DEHP), on prepubertal guinea pig testes in vitro were investigated. The testes of 35-day-old guinea pigs were surgically excised. They were seeded in a defined medium containing antibiotics and administered MEHP at concentrations of 1, 10, and 100 nmol/ml, respectively. The control groups were administered a similar volume of corn oil vehicle. The tissues were incubated for 3, 6, and 9 h. The specimens were collected at 3, 6, and 9 h after treatment. They were fixed in 4%paraformaldehyde o

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Huo, Shao-Jie, Xiu Wu, Chong Ye, et al. "In Situ Fluorescence Tracking Toxic Metabolite Mono-2-ethylhexyl phthalate (MEHP) of Di-(2-ethylhexyl) phthalate (DEHP) in HeLa Cells." Chemical Research in Toxicology 32, no. 10 (2019): 2006–15. http://dx.doi.org/10.1021/acs.chemrestox.9b00191.

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Shim, Yun, Jung Ock, Yoon-Ji Kim, Youngki Kim, Se Kim, and Dongmug Kang. "Association between Heavy Metals, Bisphenol A, Volatile Organic Compounds and Phthalates and Metabolic Syndrome." International Journal of Environmental Research and Public Health 16, no. 4 (2019): 671. http://dx.doi.org/10.3390/ijerph16040671.

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The incidence of metabolic syndrome (MetS), which causes heart disease and stroke, has increased significantly worldwide. Although many studies have revealed the relationship between heavy metals (cadmium, mercury, and lead), the sum of metabolites of di(2-ethylhexyl) phthalate (DEHP), and MetS, the results remain inconsistent. No study has reported the association between various volatile organic compounds (VOCs) and phthalate metabolites with MetS. This cross-sectional study of a representative sample of adult South Koreans aimed to evaluate the relationship between heavy metals, VOC metabol

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Cho, Yoon Hee, Yeong Sook Yoon, Min Sun Koo, et al. "Exposure to Phthalates and Alternative Plasticizers Is Associated with Methylation Changes of ESR1 and PGR in Uterine Leiomyoma: The ELENA Study." Applied Sciences 11, no. 9 (2021): 4234. http://dx.doi.org/10.3390/app11094234.

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Uterine leiomyomas are estrogen-dependent benign tumors with unknown etiologies. Phthalates are endocrine-disrupting chemicals and ubiquitous in the environment; thus, it has been suggested that they play a role in the development of uterine leiomyoma. We aimed to investigate whether the pathogenesis of uterine leiomyoma is related to methylation changes in promoter regions of estrogen receptor α (ESR1) and progesterone receptor (PGR) genes in response to phthalates and alternative plasticizers exposure. Urinary concentrations of 20 phthalate metabolites and seven metabolites of di-2-ethylhexy

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Tang, Qianqian, Bingli Lei, Yun Liu, Xiaolan Zhang, Qian Liu, and Su Sun. "The Interaction Test of Binary Mixtures of Endocrine-Disrupting Chemicals Using In Vitro Bioassays." Journal of Chemistry 2020 (June 22, 2020): 1–12. http://dx.doi.org/10.1155/2020/9729015.

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Typical environmental endocrine-disrupting chemicals (EDCs) such as estradiol valerate (EV), diethylstilbestrol (DES), di-2-ethylhexyl phthalate (DEHP), mono-2-ethylhexyl phthalate (MEHP), and bisphenol A (BPA) have a strong reproductive and developmental toxicity at low concentrations. However, information on their joint toxicity is scarce. In this study, we evaluated the combined effects of EV and other four EDCs (DES, DEHP, MEHP, and BPA) on the human breast MCF-7 cells by detecting the cell proliferation, intracellular reactive oxygen species (ROS) levels, and estrogen receptor alpha (ERα)

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Šidlovská, Miroslava, Ida Petrovičová, Branislav Kolena, Tomáš Pilka, Eva Šovčíková, and Tomáš Trnovec. "Exposure of children to phthalates and the impact of consumer practices in Slovakia." Reviews on Environmental Health 32, no. 1-2 (2017): 211–14. http://dx.doi.org/10.1515/reveh-2016-0028.

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Abstract Phthalates are environmental pollutants that can enter the human body by ingestion, inhalation and dermal absorption. Food constitutes the most important source of human exposure to these chemicals. The aim of our study was the biological monitoring of exposure to eight phthalate metabolites in children (n=107), 10–12 years of age, living in eastern Slovakia. Additionally, we analysed some associations between anthropometric measures, questionnaire data (i.e. eating and drinking habits, practice of personal care products) and concentrations of phthalate metabolites. Because of the sho

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Larsen, S. Thor, J. Stilund Hansen, M. Hammer, Y. Alarie, and G. Damgård Nielsen. "Effects of mono-2-ethylhexyl phthalate on the respiratory tract in BALB/c mice." Human & Experimental Toxicology 23, no. 11 (2004): 537–45. http://dx.doi.org/10.1191/0960327104ht486oa.

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Airborne mono-2-ethylhexyl phthalate (MEHP) was studied for acute airway effects using a bioassay with BALB/c mice. Concentration-and time-dependent effects were obtained by continuous monitoring of the breathing pattern during exposure to 0.3-43.6 mg/m3 MEHP for 60 min. Additionally, inflammatory effects of MEHP were studied from bronchoalveolar lavage (BAL) fluid. MEHP showed no upper airway irritating effect. Lower airway irritation was apparent from a concentration-dependent decrease in tidal volume (shallow respiration) with a no-observed effect level (NOEL) of 0.3 mg/m3. The respiratory

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Kolena, Branislav, Ida Petrovičová, Miroslava Šidlovská, et al. "Occupational Hazards and Risks Associated with Phthalates among Slovakian Firefighters." International Journal of Environmental Research and Public Health 17, no. 7 (2020): 2483. http://dx.doi.org/10.3390/ijerph17072483.

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Despite increasing attention to the occupational risk of firefighters, little is known about phthalate exposure. In our study, we detected mono-isobutyl phthalate (MiBP), mono-n-buthyl phthalate (MnBP), mono(2-ethyl-5-hydroxyhexyl) phthalate (5OH-MEHP), mono(2-ethyl-5-carboxypentyl) phthalate (5cx-MECPP), and mono(2-ethyl-5-oxohexyl) phthalate (5oxo-MEHP) in each urine sample. We detected positive association between MnBP, MiBP, mono-2-ethylhexyl phthalate (MEHP), 5OH-MEHP, 5oxo-MEHP, 5cx-MECPP, mono-isononyl phthalate (MiNP), the sum of low (∑LMWP) and high molecular-weight phthalates (∑HMWP)

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Rael, Leonard T., Raphael Bar-Or, Daniel R. Ambruso, et al. "Phthalate Esters Used as Plasticizers in Packed Red Blood Cell Storage Bags May Lead to Progressive Toxin Exposure and the Release of Pro-Inflammatory Cytokines." Oxidative Medicine and Cellular Longevity 2, no. 3 (2009): 166–71. http://dx.doi.org/10.4161/oxim.2.3.8608.

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Phthalate esters (PE's) are plasticizers used to soften PVC-based medical devices. PE's are the most abundant man-made pollutants and increase the risk of developing an allergic respiratory disease or a malignancy. The leaching of PE's in donated packed red blood cells (PRBC) during storage was assessed. PRBC transfusion bags containing CPD/AS-1 (ADSOL) buffer were analyzed. Samples were collected on storage day 1 and day 42. Two PE's, di-(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP), were measured by liquid chromatography coupled to mass spectrometry (LCMS). Interle

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SUNA, Shigeru, Fumihiko JlTSUNARI, Fumiyuki ASAKAWA, et al. "Simplified Determination of Di(2-ethylhexyl) Phthalate(DEHP) and Mono-(2-ethylhexyl) Phthalate (MEHP)in Blood and Organs of the Rat Administered DEHP." SANGYO EISEIGAKU ZASSHI 43, no. 4 (2001): 73–75. http://dx.doi.org/10.1539/sangyoeisei.kj00001991666.

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Kalo, D., R. Hadas, and Z. Roth. "76 EX VIVO MODEL TO STUDY THE EFFECT OF ACUTE EXPOSURE TO DI-(2-ETHYLHEXYL) PHTHALATE ON BOVINE OOCYTE MATURATION AND DEVELOPMENTAL COMPETENCE." Reproduction, Fertility and Development 27, no. 1 (2015): 131. http://dx.doi.org/10.1071/rdv27n1ab76.

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Di-(2-ethylhexyl) phthalate (DEHP) and its metabolites are environmental toxicants that potentially affect mammalian health. However, their effects on ovarian function, and in particular oocyte developmental competence, are less known. We established a model of acute exposure to DEHP to examine its immediate and long-term effects on follicles and oocyte competence. Lactating Holstein cows were synchronized and gavaged with DEHP (OXPLAST®O, ZAK, Kędzierzyn-Koźle, Poland; 100 mg kg–1 per day, n = 4) or water (n = 5) for 3 days. Liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis r

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Kambia, K., T. Dine, B. Gressier, et al. "Induction of propranolol metabolism in isolated rats hepatocytes treated by di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate (MEHP)." European Journal of Drug Metabolism and Pharmacokinetics 28, no. 3 (2003): 217–22. http://dx.doi.org/10.1007/bf03190488.

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Weldingh, Nina Mickelson, Lena Jørgensen-Kaur, Rune Becher та ін. "Bisphenol A Is More Potent than Phthalate Metabolites in Reducing Pancreatic β-Cell Function". BioMed Research International 2017 (2017): 1–11. http://dx.doi.org/10.1155/2017/4614379.

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Bisphenol A (BPA) and phthalates are common environmental contaminants that have been proposed to influence incidence and development of types 1 and 2 diabetes. Thus, effects of BPA and three phthalate metabolites (monoisobutyl phthalate (MiBP), mono-n-butyl phthalate (MnBP), and mono-(2-ethylhexyl) phthalate (MEHP)) were studied in the pancreatic β-cell line INS-1E, after 2–72 h of exposure to 5–500 μM. Three endpoints relevant to accelerated development of types 1 or 2 diabetes were investigated: β-cell viability, glucose-induced insulin secretion, and β-cell susceptibility to cytokine-induc

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Hashemi, Majid, Mohammad Mehdi Amin, Afsane Chavoshani, Nasim Rafiei, Karim Ebrahimpour, and Roya Kelishadi. "Relationship of Urinary Phthalate Metabolites with Cardiometabolic Risk Factors and Oxidative Stress Markers in Children and Adolescents." Journal of Environmental and Public Health 2021 (April 27, 2021): 1–12. http://dx.doi.org/10.1155/2021/5514073.

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Introduction. Studies have proved that exposure of adults to phthalates might be related to cardiometabolic risk factors and changes in markers of oxidative stress. Such studies conducted on school-age children and adolescents are limited and fail to assess the simultaneous effect of phthalates on these risk factors and oxidative stress markers. Therefore, it was attempted to identify the relationship of urinary phthalate metabolites with cardiometabolic risk factors and oxidative stress markers in children and adolescents. Methods. In this cross-sectional study, 108 children and adolescents,

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Kratochvil, Isabel, Tommy Hofmann, Sandra Rother та ін. "Mono(2‐ethylhexyl) phthalate (MEHP) and mono(2‐ethyl‐5‐oxohexyl) phthalate (MEOHP) but not di(2‐ethylhexyl) phthalate (DEHP) bind productively to the peroxisome proliferator‐activated receptor γ". Rapid Communications in Mass Spectrometry 33, S1 (2019): 75–85. http://dx.doi.org/10.1002/rcm.8258.

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Cai, Wei, Jule Yang, Yini Liu, Yongyi Bi, and Hong Wang. "Association between Phthalate Metabolites and Risk of Endometriosis: A Meta-Analysis." International Journal of Environmental Research and Public Health 16, no. 19 (2019): 3678. http://dx.doi.org/10.3390/ijerph16193678.

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Objective: The association between phthalates and endometriosis risk is inconclusive. This meta-analysis aims to evaluate the association between five different phthalate metabolites and endometriosis, based on current evidence. Methods: The literature included PubMed, WOS (web of science), and EMBASE, published until 3 March 2019. We selected the related literature and evaluated the relationship between phthalates exposure and endometriosis risk. All statistical analyses were conducted with STATA version 12.0. Results: Data from eight studies were used in this review. The results of this anal

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Erkekoglu, Pinar, Walid Rachidi, Ozge Gursoy Yuzugullu, et al. "Corrigendum to “Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on 62]." Toxicology and Applied Pharmacology 273, no. 2 (2013): 425. http://dx.doi.org/10.1016/j.taap.2013.05.032.

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Liu, Ge, Wei Cai, Huan Liu, Haihong Jiang, Yongyi Bi, and Hong Wang. "The Association of Bisphenol A and Phthalates with Risk of Breast Cancer: A Meta-Analysis." International Journal of Environmental Research and Public Health 18, no. 5 (2021): 2375. http://dx.doi.org/10.3390/ijerph18052375.

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Background: Breast cancer is the most common cancer and the second leading cause of cancer-related death amongst American women. Endocrine-disrupting chemicals (EDCs), especially bisphenol A (BPA) and phthalates, have adverse effects on human health. However, the association of BPA and phthalates with breast cancer remains conflicting. This study aims to investigate the association of BPA and phthalates with breast cancer. Methods: Correlative studies were identified by systematically searching three electronic databases, namely, PubMed, Web of Sciences, and Embase, up to November 2020. All da

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Roth, Z., R. Hadas, Y. Maor, and D. Kalo. "166 IN VIVO MODEL TO EXAMINE THE LONG-LASTING EFFECTS OF ACUTE DI-(2-ETHYLHEXYL) PHTHALATE (DEHP) EXPOSURE ON OVARIAN FUNCTION IN BOVINE." Reproduction, Fertility and Development 27, no. 1 (2015): 174. http://dx.doi.org/10.1071/rdv27n1ab166.

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Di-(2-ethylhexyl) phthalate (DEHP) is a commonly used plasticizer. Its metabolites have been shown to have adverse effects on reproduction and development in laboratory animals. However, the mechanisms by which they induce infertility remain elusive. We established an experimental model in which lactating Holstein cows were synchronized (GnRH–PG–GnRH) and tube-fed with DEHP (100 mg kg–1 per day; n = 4) or water (n = 5), for 3 days. Urine and plasma samples were collected before (Day 0), during (Days 2 and 4), and after (Days 11, 19, and 24) treatment initiation. For each group, and on each day

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Kessler, Winfried, Wanwiwa Numtip, Wolfgang Völkel, et al. "Kinetics of di(2-ethylhexyl) phthalate (DEHP) and mono(2-ethylhexyl) phthalate in blood and of DEHP metabolites in urine of male volunteers after single ingestion of ring-deuterated DEHP." Toxicology and Applied Pharmacology 264, no. 2 (2012): 284–91. http://dx.doi.org/10.1016/j.taap.2012.08.009.

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Lhuguenot, Jean-Claude, Angela M. Mitchell, Gary Milner, Edward A. Lock, and Clifford R. Elcombe. "The metabolism of di(2-ethylhexyl) phthalate (DEHP) and mono-(2-ethylhexyl) phthalate (MEHP) in rats: In vivo and in vitro dose and time dependency of metabolism." Toxicology and Applied Pharmacology 80, no. 1 (1985): 11–22. http://dx.doi.org/10.1016/0041-008x(85)90096-1.

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Mittermeier, Astrid, Wolfgang Völkel, and Hermann Fromme. "Kinetics of the phthalate metabolites mono-2-ethylhexyl phthalate (MEHP) and mono-n-butyl phthalate (MnBP) in male subjects after a single oral dose." Toxicology Letters 252 (June 2016): 22–28. http://dx.doi.org/10.1016/j.toxlet.2016.04.009.

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Varshavsky, Julia R., Rachel Morello-Frosch, Suhash Harwani, et al. "A Pilot Biomonitoring Study of Cumulative Phthalates Exposure among Vietnamese American Nail Salon Workers." International Journal of Environmental Research and Public Health 17, no. 1 (2020): 325. http://dx.doi.org/10.3390/ijerph17010325.

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Many California nail salon workers are low-income Vietnamese women of reproductive age who use nail products daily that contain androgen-disrupting phthalates, which may increase risk of male reproductive tract abnormalities during pregnancy. Yet, few studies have characterized phthalate exposures among this workforce. To characterize individual metabolites and cumulative phthalates exposure among a potentially vulnerable occupational group of nail salon workers, we collected 17 post-shift urine samples from Vietnamese workers at six San Francisco Bay Area nail salons in 2011, which were analy

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Rafael-Vázquez, L., B. Bazan-Perkins, D. Romero, and B. Quintanilla-Vega. "Effects of Di(2-ethylhexyl) phthalate (DEHP) and Mono(2-ethylhexyl) phthalate (MEHP) on cell progression and expression of proteins of epithelial-mesenquimal transition: a possible effect on fibrosis?" Toxicology Letters 259 (October 2016): S247. http://dx.doi.org/10.1016/j.toxlet.2016.07.725.

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Erkekoglu, Pinar, Walid Rachidi, Ozge Gursoy Yuzugullu, et al. "Evaluation of cytotoxicity and oxidative DNA damaging effects of di(2-ethylhexyl)-phthalate (DEHP) and mono(2-ethylhexyl)-phthalate (MEHP) on MA-10 Leydig cells and protection by selenium." Toxicology and Applied Pharmacology 248, no. 1 (2010): 52–62. http://dx.doi.org/10.1016/j.taap.2010.07.016.

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Caporossi, Lidia, Alessandra Alteri, Giovanni Campo, et al. "Cross Sectional Study on Exposure to BPA and Phthalates and Semen Parameters in Men Attending a Fertility Center." International Journal of Environmental Research and Public Health 17, no. 2 (2020): 489. http://dx.doi.org/10.3390/ijerph17020489.

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Among the possible risk factors for male reproduction, exposure to phthalates and alkylphenols is widely documented. This study evaluated the possible association between chemical exposure and the quality of the seminal fluid of 105 subjects in a fertility clinic. The urinary levels of seven phthalate metabolites (monoethylphthalate, MEP; monobenzylphthalate, MBzP; mono n-butylphthalate, MnBP; mono-(2-ethylhexyl) phthalate, MEHP; mono(2-ethyl-5-hydroxyhexyl) phthalate, MEHHP; mono-n-octylphthalate, MnOP; mono-isononylphthalate, MiNP) and bisphenol A (BPA), were analysed by high performance liq

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Chu, Po-Ching, Charlene Wu, and Ta-Chen Su. "Association between Urinary Phthalate Metabolites and Markers of Endothelial Dysfunction in Adolescents and Young Adults." Toxics 9, no. 2 (2021): 33. http://dx.doi.org/10.3390/toxics9020033.

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Endothelial function is crucial in the pathogenesis of circulatory and cardiovascular toxicity; epidemiologic research investigating the association between phthalate exposure and endothelial dysfunction remains limited. We examined the associations between exposures to specific phthalates (di-2-ethylhexyl phthalate, DEHP; di-n-butyl phthalate, DnBP) and circulating endothelial and platelet microparticles (EMPs and PMPs) in adolescents and young adults. Of the 697 participants recruited, anthropometric measurements and health-related behaviors relevant to cardiovascular risks were collected an

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Fischer, Frank-Peter, Christoph Machleidt, Albert W. Rettenmeier, Ulrich Kuhlmann, and Thomas Mettang. "Plasticizers and Inhibition of Leukocyte Function in Vitro." Peritoneal Dialysis International: Journal of the International Society for Peritoneal Dialysis 18, no. 6 (1998): 620–25. http://dx.doi.org/10.1177/089686089801800610.

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Objectives To evaluate the influence of the plasticizer metabolites of di(2-ethylhexyl)phthalate (DEHP), mono(2-ethylhexyl)phthalate (ME HP), 2-ethylhexanol (2-EH), and phthalic acid (PA) on various immune functions of poly-morphonuclear blood leukocytes (PMNL) and monocytes (MN). ME HP, 2-EH, and PA are the main hydrolysis products of DE HP. Since DE HP is leached out of the plastic matrix, patients on hemodialysis and continuous ambulatory peritoneal dialysis are exposed to considerable amounts of DE HP and its metabolites. Setting Teaching hospital, Department of Nephrology. Participants Te

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Hoyer, Patricia B. "Reproductive toxicology: current and future directions11Abbreviations: FSH, follicle-stimulating hormone; LH, luteinizing hormone; PAH, polycyclic aromatic hydrocarbon; DBP, di-n-butyl phthalate; DEHP, di-(2-ethylhexyl)phthlate; MEHP, mono-2-(ethylhexyl)phthlate; DDT, dichlorodiphenyl-trichloroethane; p,p′-DDE, 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene; PCB, polychlorinated biphenyl; BPA, bisphenol A; and cAMP, cyclic AMP." Biochemical Pharmacology 62, no. 12 (2001): 1557–64. http://dx.doi.org/10.1016/s0006-2952(01)00814-0.

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Wu, Anna H., Adrian A. Franke, Lynne R. Wilkens, et al. "Urinary phthalate exposures and risk of breast cancer: the Multiethnic Cohort study." Breast Cancer Research 23, no. 1 (2021). http://dx.doi.org/10.1186/s13058-021-01419-6.

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Abstract Background The epidemiologic evidence from observational studies on breast cancer risk and phthalates, endocrine disrupting chemicals, has been inconsistent. In the only previous study based on pre-diagnostic urinary phthalates and risk of breast cancer, results were null in mostly white women. Methods We examined the association between pre-diagnostic urinary phthalates and breast cancer in a nested case-control study within the Multiethnic Cohort (MEC) study, presenting the first data from five major racial/ethnic groups in the USA. We measured 10 phthalate metabolites and phthalic

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Rock, G., R. S. Labow, C. Franklin, R. Burnett, and M. Tocchi. "Plasticizer Interaction with Stored Blood Produces a Toxic Metabolite, Mono(2-Ethylhexyl)Phthalate." MRS Proceedings 110 (1987). http://dx.doi.org/10.1557/proc-110-767.

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AbstractMost medical devices utilized in blood storage and transfusion, as well as in many medical and surgical procedures, are manufactured with polyvinylchloride (PVC) plastic containing the plasticizer di(2-ethylhexyl)phthalate (DEHP). During exposure of blood to the plastic surface, the DEHP is leached into the plasma where it is converted to mono(2-ethylhexyl)phthalate (MEHP) by a plasma enzyme in vivo or ex vivo during storage in plastic containers. The toxic effects of MEHP when infused into rats were investigated. The amount of MEHP infused was based on MEHP levels found in a variety o

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Lin, Chun-Yu, Chung-Hao Huang, Wen-Hung Wang, et al. "Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses." Frontiers in Immunology 12 (February 15, 2021). http://dx.doi.org/10.3389/fimmu.2021.599345.

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Exposure to environmental hormones such as di(2-ethylhexyl) phthalate (DEHP) has become a critical human health issue globally. This study aimed to investigate the correlations between DEHP/mono-(2-ethylhexyl) phthalate (MEHP) levels and macrophage-associated immune responses and clinical manifestations in dengue virus (DV)-infected patients. Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/

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Chen, Yi-Huan, Yi-Ju Wu, Wei-Cheng Chen, et al. "MEHP interferes with mitochondrial functions and homeostasis in skeletal muscle cells." Bioscience Reports 40, no. 4 (2020). http://dx.doi.org/10.1042/bsr20194404.

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Abstract Di (2-ethylhexyl) phthalate (DEHP) is a plasticizer frequently leached out from polyvinyl chloride (PVC) products and is quickly metabolized to its monoester equivalent mono(2-ethylhexyl) phthalate (MEHP) once enters organisms. Exposure to DEHP/MEHP through food chain intake has been shown to modified metabolism but its effect on the development of metabolic myopathy of skeletal muscle (SKM) has not been revealed so far. Here, we found that MEHP repressed myogenic terminal differentiation of proliferating myoblasts (PMB) and confluent myoblasts (CMB) but had weak effect on this proces

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