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1

Bauckmann, Jana. "Dependency discovery for data integration." Phd thesis, Universität Potsdam, 2013. http://opus.kobv.de/ubp/volltexte/2013/6664/.

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Data integration aims to combine data of different sources and to provide users with a unified view on these data. This task is as challenging as valuable. In this thesis we propose algorithms for dependency discovery to provide necessary information for data integration. We focus on inclusion dependencies (INDs) in general and a special form named conditional inclusion dependencies (CINDs): (i) INDs enable the discovery of structure in a given schema. (ii) INDs and CINDs support the discovery of cross-references or links between schemas. An IND “A in B” simply states that all values of attribute A are included in the set of values of attribute B. We propose an algorithm that discovers all inclusion dependencies in a relational data source. The challenge of this task is the complexity of testing all attribute pairs and further of comparing all of each attribute pair's values. The complexity of existing approaches depends on the number of attribute pairs, while ours depends only on the number of attributes. Thus, our algorithm enables to profile entirely unknown data sources with large schemas by discovering all INDs. Further, we provide an approach to extract foreign keys from the identified INDs. We extend our IND discovery algorithm to also find three special types of INDs: (i) Composite INDs, such as “AB in CD”, (ii) approximate INDs that allow a certain amount of values of A to be not included in B, and (iii) prefix and suffix INDs that represent special cross-references between schemas. Conditional inclusion dependencies are inclusion dependencies with a limited scope defined by conditions over several attributes. Only the matching part of the instance must adhere the dependency. We generalize the definition of CINDs distinguishing covering and completeness conditions and define quality measures for conditions. We propose efficient algorithms that identify covering and completeness conditions conforming to given quality thresholds. The challenge for this task is twofold: (i) Which (and how many) attributes should be used for the conditions? (ii) Which attribute values should be chosen for the conditions? Previous approaches rely on pre-selected condition attributes or can only discover conditions applying to quality thresholds of 100%. Our approaches were motivated by two application domains: data integration in the life sciences and link discovery for linked open data. We show the efficiency and the benefits of our approaches for use cases in these domains.<br>Datenintegration hat das Ziel, Daten aus unterschiedlichen Quellen zu kombinieren und Nutzern eine einheitliche Sicht auf diese Daten zur Verfügung zu stellen. Diese Aufgabe ist gleichermaßen anspruchsvoll wie wertvoll. In dieser Dissertation werden Algorithmen zum Erkennen von Datenabhängigkeiten vorgestellt, die notwendige Informationen zur Datenintegration liefern. Der Schwerpunkt dieser Arbeit liegt auf Inklusionsabhängigkeiten (inclusion dependency, IND) im Allgemeinen und auf der speziellen Form der Bedingten Inklusionsabhängigkeiten (conditional inclusion dependency, CIND): (i) INDs ermöglichen das Finden von Strukturen in einem gegebenen Schema. (ii) INDs und CINDs unterstützen das Finden von Referenzen zwischen Datenquellen. Eine IND „A in B“ besagt, dass alle Werte des Attributs A in der Menge der Werte des Attributs B enthalten sind. Diese Arbeit liefert einen Algorithmus, der alle INDs in einer relationalen Datenquelle erkennt. Die Herausforderung dieser Aufgabe liegt in der Komplexität alle Attributpaare zu testen und dabei alle Werte dieser Attributpaare zu vergleichen. Die Komplexität bestehender Ansätze ist abhängig von der Anzahl der Attributpaare während der hier vorgestellte Ansatz lediglich von der Anzahl der Attribute abhängt. Damit ermöglicht der vorgestellte Algorithmus unbekannte Datenquellen mit großen Schemata zu untersuchen. Darüber hinaus wird der Algorithmus erweitert, um drei spezielle Formen von INDs zu finden, und ein Ansatz vorgestellt, der Fremdschlüssel aus den erkannten INDs filtert. Bedingte Inklusionsabhängigkeiten (CINDs) sind Inklusionsabhängigkeiten deren Geltungsbereich durch Bedingungen über bestimmten Attributen beschränkt ist. Nur der zutreffende Teil der Instanz muss der Inklusionsabhängigkeit genügen. Die Definition für CINDs wird in der vorliegenden Arbeit generalisiert durch die Unterscheidung von überdeckenden und vollständigen Bedingungen. Ferner werden Qualitätsmaße für Bedingungen definiert. Es werden effiziente Algorithmen vorgestellt, die überdeckende und vollständige Bedingungen mit gegebenen Qualitätsmaßen auffinden. Dabei erfolgt die Auswahl der verwendeten Attribute und Attributkombinationen sowie der Attributwerte automatisch. Bestehende Ansätze beruhen auf einer Vorauswahl von Attributen für die Bedingungen oder erkennen nur Bedingungen mit Schwellwerten von 100% für die Qualitätsmaße. Die Ansätze der vorliegenden Arbeit wurden durch zwei Anwendungsbereiche motiviert: Datenintegration in den Life Sciences und das Erkennen von Links in Linked Open Data. Die Effizienz und der Nutzen der vorgestellten Ansätze werden anhand von Anwendungsfällen in diesen Bereichen aufgezeigt.
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Giannella, Chris. "Approximate functional dependency discovery and one-dimensional selectivity estimation." [Bloomington, Ind.] : Indiana University, 2004. http://wwwlib.umi.com/dissertations/fullcit/3162234.

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Thesis (Ph.D.)--Indiana University, Dept. of Computer Science, 2004.<br>Title from PDF t.p. (viewed Dec. 1, 2008). Source: Dissertation Abstracts International, Volume: 66-01, Section: B, page: 0361. Chair: Edward Robertson.
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3

Bauckmann, Jana [Verfasser], and Felix [Akademischer Betreuer] Naumann. "Dependency discovery for data integration / Jana Bauckmann. Betreuer: Felix Naumann." Potsdam : Universitätsbibliothek der Universität Potsdam, 2013. http://d-nb.info/1037251431/34.

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4

Moss, Mark Bomi. "Assessing operational impact in enterprise systems with dependency discovery and usage mining." Diss., Atlanta, Ga. : Georgia Institute of Technology, 2009. http://hdl.handle.net/1853/31795.

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Thesis (Ph.D)--Computing, Georgia Institute of Technology, 2010.<br>Committee Chair: Pu, Calton; Committee Member: Ahamad, Mustaque; Committee Member: Liu, Ling; Committee Member: Mark, Leo; Committee Member: Owen, Henry. Part of the SMARTech Electronic Thesis and Dissertation Collection.
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5

Clawson, John K. "Service Dependency Analysis via TCP/UDP Port Tracing." BYU ScholarsArchive, 2015. https://scholarsarchive.byu.edu/etd/5479.

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Enterprise networks are traditionally mapped via layers two or three, providing a view of what devices are connected to different parts of the network infrastructure. A method was developed to map connections at layer four, providing a view of interconnected systems and services instead of network infrastructure. This data was graphed and displayed in a web application. The information proved beneficial in identifying connections between systems or imbalanced clusters when troubleshooting problems with enterprise applications.
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6

Abedjan, Ziawasch, and Felix Naumann. "Advancing the discovery of unique column combinations." Universität Potsdam, 2011. http://opus.kobv.de/ubp/volltexte/2011/5356/.

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Unique column combinations of a relational database table are sets of columns that contain only unique values. Discovering such combinations is a fundamental research problem and has many different data management and knowledge discovery applications. Existing discovery algorithms are either brute force or have a high memory load and can thus be applied only to small datasets or samples. In this paper, the wellknown GORDIAN algorithm and "Apriori-based" algorithms are compared and analyzed for further optimization. We greatly improve the Apriori algorithms through efficient candidate generation and statistics-based pruning methods. A hybrid solution HCAGORDIAN combines the advantages of GORDIAN and our new algorithm HCA, and it significantly outperforms all previous work in many situations.<br>Unique-Spaltenkombinationen sind Spaltenkombinationen einer Datenbanktabelle, die nur einzigartige Werte beinhalten. Das Finden von Unique-Spaltenkombinationen spielt sowohl eine wichtige Rolle im Bereich der Grundlagenforschung von Informationssystemen als auch in Anwendungsgebieten wie dem Datenmanagement und der Erkenntnisgewinnung aus Datenbeständen. Vorhandene Algorithmen, die dieses Problem angehen, sind entweder Brute-Force oder benötigen zu viel Hauptspeicher. Deshalb können diese Algorithmen nur auf kleine Datenmengen angewendet werden. In dieser Arbeit werden der bekannte GORDIAN-Algorithmus und Apriori-basierte Algorithmen zum Zwecke weiterer Optimierung analysiert. Wir verbessern die Apriori Algorithmen durch eine effiziente Kandidatengenerierung und Heuristikbasierten Kandidatenfilter. Eine Hybride Lösung, HCA-GORDIAN, kombiniert die Vorteile von GORDIAN und unserem neuen Algorithmus HCA, welche die bisherigen Algorithmen hinsichtlich der Effizienz in vielen Situationen übertrifft.
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Fouché, Edouard [Verfasser], and K. [Akademischer Betreuer] Böhm. "Estimating Dependency, Monitoring and Knowledge Discovery in High-Dimensional Data Streams / Edouard Fouché ; Betreuer: K. Böhm." Karlsruhe : KIT-Bibliothek, 2020. http://d-nb.info/1223027821/34.

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8

Toman, František. "Vylepšení nástroje ServiceNow Discovery v oblastech aplikačních vztahů a konfigurací aplikací." Master's thesis, Vysoká škola ekonomická v Praze, 2014. http://www.nusl.cz/ntk/nusl-193040.

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The main focus of this paper is to improve the ServiceNow Discovery tool in two areas. The first one is the Application Dependency Mapping (ADM). ServiceNow is currently not able to determine the type of the relationship between two applications. As a solution, a new application was designed and implemented. It enables human element to define the type of relationship before it is found by the Discovery. This application also makes it posiible to define rules, which affect the behaviour of ADM. Second area, taken into account in this paper, is the discovery of application configuration. Weaknesses of Discovery are identified and solution is implemented.
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9

Utku, Selma. "Web Service Testing For Domain Specific Web Service Discovery Framework." Master's thesis, METU, 2012. http://etd.lib.metu.edu.tr/upload/12614083/index.pdf.

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The reliability of web services is important for both users and other service providers, with which they are in interaction. Thus, to guarantee reliability of the web services that are invoked and integrated at runtime, automatic testing of web services is needed. In web service testing, different test cases for web services are generated. The most important issue is to generate the most appropriate value for input parameters of web services at runtime. In this thesis, we developed a method for automatic web service testing that uses semantics dependency-based and data mutation-based techniques to analyze web services and generate different test cases. Thus, we both check whether the services function correctly by generating appropriate input values from different data sources and check robustness of web services by generating random and error-prone data inputs. With respect to the behaviors of web services, the test values are calculated and saved to the database for each web service.
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Bauckmann, Jana, Ziawasch Abedjan, Ulf Leser, Heiko Müller, and Felix Naumann. "Covering or complete? : Discovering conditional inclusion dependencies." Universität Potsdam, 2012. http://opus.kobv.de/ubp/volltexte/2012/6208/.

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Data dependencies, or integrity constraints, are used to improve the quality of a database schema, to optimize queries, and to ensure consistency in a database. In the last years conditional dependencies have been introduced to analyze and improve data quality. In short, a conditional dependency is a dependency with a limited scope defined by conditions over one or more attributes. Only the matching part of the instance must adhere to the dependency. In this paper we focus on conditional inclusion dependencies (CINDs). We generalize the definition of CINDs, distinguishing covering and completeness conditions. We present a new use case for such CINDs showing their value for solving complex data quality tasks. Further, we define quality measures for conditions inspired by precision and recall. We propose efficient algorithms that identify covering and completeness conditions conforming to given quality thresholds. Our algorithms choose not only the condition values but also the condition attributes automatically. Finally, we show that our approach efficiently provides meaningful and helpful results for our use case.<br>Datenabhängigkeiten (wie zum Beispiel Integritätsbedingungen), werden verwendet, um die Qualität eines Datenbankschemas zu erhöhen, um Anfragen zu optimieren und um Konsistenz in einer Datenbank sicherzustellen. In den letzten Jahren wurden bedingte Abhängigkeiten (conditional dependencies) vorgestellt, die die Qualität von Daten analysieren und verbessern sollen. Eine bedingte Abhängigkeit ist eine Abhängigkeit mit begrenztem Gültigkeitsbereich, der über Bedingungen auf einem oder mehreren Attributen definiert wird. In diesem Bericht betrachten wir bedingte Inklusionsabhängigkeiten (conditional inclusion dependencies; CINDs). Wir generalisieren die Definition von CINDs anhand der Unterscheidung von überdeckenden (covering) und vollständigen (completeness) Bedingungen. Wir stellen einen Anwendungsfall für solche CINDs vor, der den Nutzen von CINDs bei der Lösung komplexer Datenqualitätsprobleme aufzeigt. Darüber hinaus definieren wir Qualitätsmaße für Bedingungen basierend auf Sensitivität und Genauigkeit. Wir stellen effiziente Algorithmen vor, die überdeckende und vollständige Bedingungen innerhalb vorgegebener Schwellwerte finden. Unsere Algorithmen wählen nicht nur die Werte der Bedingungen, sondern finden auch die Bedingungsattribute automatisch. Abschließend zeigen wir, dass unser Ansatz effizient sinnvolle und hilfreiche Ergebnisse für den vorgestellten Anwendungsfall liefert.
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Xosanavongsa, Charles. "Heterogeneous Event Causal Dependency Definition for the Detection and Explanation of Multi-Step Attacks." Thesis, CentraleSupélec, 2020. http://www.theses.fr/2020CSUP0003.

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Partant du constat qu'un attaquant motivé finit par réussir à s'infiltrer dans un réseau malgré les moyens de prévention déployés, la mise en place d'une supervision de sécurité est indispensable. L'objectif de cette thèse est de permettre la découverte de scénarios d'attaque multi-étapes à travers l'analyse d'événements de sécurité. Pour atteindre cet objectif, les approches précédentes visent à construire des liens entre les événements et entre les étapes d'une attaque.En pratique, ces liens sont difficiles à définir et découvrir, notamment lorsque l'on considère l'analyse d'événements hétérogènes (c.-à-d. produits par différents types de systèmes de supervision). De plus, la littérature ne propose pas de définition formelle de ce lien. Selon nous, ce lien correspond à une relation de dépendance causale. Inspirés de deux modèles de causalité précédemment définis dans les domaines des systèmes distribués (modèle de Lamport) et de la sécurité (modèle de d'Ausbourg), nous avons donc proposé une définition formelle de cette relation dénommée event causal dependency. Cette relation permet la découverte de tous les événements pouvant être considérés comme les causes, ou les effets, d'un événement d'intérêt telle qu'une alerte.À notre connaissance, nos travaux sont les premiers à proposer une définition formelle de la relation de dépendance causale entre événements hétérogènes. Actuellement, les méthodes proposées dans la littérature ne permettent de construire qu'une approximation de notre modèle. Notre implémentation a la particularité de se baser uniquement sur l'analyse d'événements issus de COTS. Cette dernière permet d'obtenir une bonne approximation de notre modèle<br>Knowing that a persistent attacker will eventually succeed in gaining a foothold inside the targeted network despite prevention mechanisms, it is mandatory to perform security monitoring on the system. The purpose of this thesis is to enable the discovery of multi-step attacks through logged events analysis. To that end, previous alert correlation work has aimed at building connections among events and between attack steps. In practice, this type of link is not trivial to define and discover, especially when considering heterogeneous events (i.e., events emanating from monitoring systems deployed in different abstraction layers of the monitored system), and the literature lacks a formal definition of these connections. We argue that the connections among heterogeneous events correspond to causal dependency relationships among events.Inspired from two causality models from the distributed system and the security research areas, i.e., Lamport's and d'Ausbourg's models, we have thereby proposed a formal definition of this relationship called event causal dependency. The relationship enables the discovery of all events, which can be considered as the cause or the effect of an event of interest (e.g., an IDS alert).To the best of our knowledge, our work is the first one to propose a formal definition of the causal dependency relationship among heterogeneous events. We present how existing work permits the computation of parts of the overall model, and detail our implementation, which exclusively leverages existing monitoring facilities (e.g., auditd, or Zeek NIDS) to produce events. We show that our implementation already yields a good approximation of our model
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Garnaud, Eve. "Dépendances fonctionnelles : extraction et exploitation." Phd thesis, Université Sciences et Technologies - Bordeaux I, 2013. http://tel.archives-ouvertes.fr/tel-00951619.

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Les dépendances fonctionnelles fournissent une information sémantique sur les données d'une table en mettant en lumière les liens de corrélation qui les unient. Dans cette thèse, nous traitons du problème de l'extraction de ces dépendances en proposant un contexte unifié permettant la découverte de n'importe quel type de dépendances fonctionnelles (dépendances de clé, dépendances fonctionnelles conditionnelles, que la validité soit complète ou approximative). Notre algorithme, ParaCoDe, s'exécute en parallèle sur les candidats, réduisant ainsi le temps global de calcul. De ce fait, il est très compétitif vis-à-vis des approches séquentielles connues à ce jour. Les dépendances satisfaites sur une table nous servent à résoudre le problème de la matérialisation partielle du cube de données. Nous présentons une caractérisation de la solution optimale dans laquelle le coût de chaque requête est borné par un seuil de performance fixé préalablement et dont la taille est minimale. Cette spécification de la solution donne un cadre unique pour décrire et donc comparer formellement les techniques de résumé de cubes de données.
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Tao, Hui. "An Investigation of False Discovery Rates in Multiple Testing under Dependence." Fogler Library, University of Maine, 2005. http://www.library.umaine.edu/theses/pdf/TaoH2005.pdf.

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14

Clements, Nicolle. "Multiple Testing in Grouped Dependent Data." Diss., Temple University Libraries, 2013. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/253695.

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Statistics<br>Ph.D.<br>This dissertation is focused on multiple testing procedures to be used in data that are naturally grouped or possess a spatial structure. We propose `Two-Stage' procedure to control the False Discovery Rate (FDR) in situations where one-sided hypothesis testing is appropriate, such as astronomical source detection. Similarly, we propose a `Three-Stage' procedure to control the mixed directional False Discovery Rate (mdFDR) in situations where two-sided hypothesis testing is appropriate, such as vegetation monitoring in remote sensing NDVI data. The Two and Three-Stage procedures have provable FDR/mdFDR control under certain dependence situations. We also present the Adaptive versions which are examined under simulation studies. The `Stages' refer to testing hypotheses both group-wise and individually, which is motivated by the belief that the dependencies among the p-values associated with the spatially oriented hypotheses occur more locally than globally. Thus, these `Staged' procedures test hypotheses in groups that incorporate the local, unknown dependencies of neighboring p-values. If a group is found significant, further investigation is done to the individual p-values within that group. For the vegetation monitoring data, we extend the investigation by providing some spatio-temporal models and forecasts to some regions where significant change was detected through the multiple testing procedure.<br>Temple University--Theses
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Lee, Su-Lin. "Targeting the phosphoinositide-dependent protein kinase-2 for anticancer drug discovery." The Ohio State University, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=osu1337980277.

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Jali, Abdulmajeed. "DISCOVERY OF MOR SELECTIVE, REVERSIBLE OPIOID ANTAGONIST FOR POTENTIAL USE IN TREATMENT OF DRUG DEPENDENCE." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5020.

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Abstract DISCOVERY OF MOR SELECTIVE, REVERSIBLE OPIOID ANTAGONIST FOR POTENTIAL USE IN TREATMENT OF DRUG DEPENDENCE Abdulmajeed M. Jali, M.S. A thesis submitted in partial fulfillment of the requirements of Master of Science at Virginia Commonwealth University. Virginia Commonwealth University, 2017 Director: Dana E. Selley, Ph. D., Department of Pharmacology and Toxicology Opioid dependence/addiction is a major public health problem that is associated with multiple health and social costs. Pharmacotherapeutic treatment has been relatively effective, but the risk of relapse after treatment remains high. Naltrexone, an opioid antagonist, is FDA-approved for long-term maintenance therapy to reduce relapse risk. However, naltrexone is accompanied by side-effects that are due to lack of selectivity among opioid receptor types. Based on the message-address concept and molecular modeling studies, 18 novel compounds designed to bind selectively to the MOR based on interaction with a key aromatic residue, were synthesized by our collaborators. The purpose of this study was to identify MOR-selective antagonists from this series of compounds. Using radioligand and GTPgS binding assays in transfected cells and native tissues, two compounds were discovered with the high MOR-selectivity and low efficacy required to serves as lead ligands in future discovery efforts toward next-generation opioid antagonists.
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Barthel, Alexander. "Analysis, Implementation and Enhancement of Vendor dependent and independent Layer-2 Network Topology Discovery." Master's thesis, Universitätsbibliothek Chemnitz, 2005. http://nbn-resolving.de/urn:nbn:de:swb:ch1-200500455.

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This work shows and implements possibilities of OSI Layer-2 Network Topology Discovery based on information from Cisco Discovery Protocol, Spanning Tree Protocol and Switches' Filtering Databases<br>Diese Arbeit zeigt und implementiert Möglichkeiten zur OSI Layer-2 Netzwerk Topologie Erkennung basierend auf Informationen des Cisco Discovery Protocol, Spanning Tree Protocol und Switch Filter Datenbanken
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Holliday, Casey Jane. "Discovery of shear- and side-dependent messenger RNAs and microRNAs in aortic valvular endothelium." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/47517.

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Aortic valve (AV) disease is a major cause of cardiovascular-linked deaths globally. In addition, AV disease is a strong risk factor for additional cardiovascular events; however, the mechanism by which it initiates and progresses is not well-understood. We hypothesize that low and oscillatory flow is present on the fibrosa side of the AV and stimulates ECs to differentially regulate microRNA (miRNA) and mRNAs and influence AV disease progression. This hypothesis was tested employing both in vitro and in vivo approaches, high throughput microarray and pathway analyses, as well as a variety of functional assays. First, we isolated and characterized side-dependent, human aortic valvular endothelial cells (HAVECs). We found that HAVECs express both endothelial cell markers (VE-Cadherin, vWF, and PECAM) as well as smooth muscle cell markers (SMA and basic calponin). Using microarray analysis on sheared, side-specific HAVECs, we identified side- and shear-induced changes in miRNA and mRNA expression profiles. More specifically, we identified over 1000 shear-responsive mRNAs which showed robust validation (93% of those tested). We then used Ingenuity Pathway Analysis to identify key miRNAs, including those with many relationships to other genes (for example, thrombospondin and I&B) and those that are members of over-represented pathways and processes (for example, sulfur metabolism). Furthermore, we validated five shear-sensitive miRNAs: miR-139-3p, miR-148a, miR-187, miR-192, and miR-486-5p and one side-dependent miRNA, miR-370. To prioritize these miRNAs, we performed in silico analysis to group these key miRNAs by cellular functions related to AV disease (including tissue remodeling, inflammation, and calcification). Next, to compare our in vitro HAVEC results in vivo, we developed a method to isolate endothelial-enriched, side-dependent total RNA and identify and validate side-dependent (fibrosa vs. ventricularis) miRNAs in porcine aortic valvular endothelium. From this analysis, we discovered and validated eight side-dependent miRNAs in porcine endothelial-enriched AV RNA, including one miRNA previously identified in vitro, miR-486-5p. Lastly, we determined the relationship between important miRNAs (specifically miR-187 and miR-486-5p) and AV disease by modulating levels of miRNAs and performing functional assays. Preliminary studies overexpressing miR-187 in HAVECs have shown a reduction in inflammatory state through monocyte adhesion (p<0.05). Further, miR-486-5p overexpression reveals an increase in migration (p<0.05) and a trend for a decrease in early apoptosis, linking miR-486-5p to tissue remodeling in the AV. Better understanding of AV biology and disease in terms of gene-regulation under different hemodynamic conditions will facilitate the design of a tissue-engineered valve and provide alternative treatment options.
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TEMBE, WAIBHAV DEEPAK. "PATTERN EXTRACTION USING A CONTEXT DEPENDENT MEASURE OF DIVERGENCE AND ITS VALIDATION." University of Cincinnati / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ucin994882030.

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Gavelli, Alessandro. "Verso Industry 4.0: profilazione di dati telemetrici di produzione presso Bonfiglioli Riduttori S.p.A." Master's thesis, Alma Mater Studiorum - Università di Bologna, 2021.

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Nella cosiddetta “era dei Big Data” le aziende sono sempre più guidate dai dati nel prendere decisioni strategiche, tanto che è stato coniato il termine data-drive companies per descrivere questo fenomeno. Tra le numerose tipologie di dati, l’acquisizione di quelli telemetrici, ovvero ottenuti a partire da sensori posizionati sulle macchine, si sta sempre più affermando grazie al paradigma dell’Industria 4.0. Il vantaggio principale consiste nella possibilità di utilizzare le informazioni ricavabili per aumentare la produttività degli impianti, in particolare grazie alla manutenzione predittiva. La trasformazione da dato in informazione ed infine in conoscenza non può però prescindere dalla presenza di metadati in grado di fornire alcune informazioni preliminari e riassuntive relative alla distribuzione dei dati e dalla qualità di questi ultimi. Il progetto realizzato presso l’ufficio IT di Bonfiglioli Riduttori S.p.A. ha proprio l’obiettivo di creare tabelle e dashboard in grado di raccogliere e presentare grandezze, tra cui media, deviazione standard, massimo e minimo, calcolate per le variabili telemetriche di coppia, corrente e potenza raccolte dall’azienda dalle proprie macchine e progettare un “engine” volto a verificare l’eventuale presenza di valori anomali, frutto di un possibile problema di mapping delle variabili. Gli output prodotti andranno a supportare l’implementazione della manutenzione predittiva sulle macchine presenti negli stabilimenti produttivi dell’azienda.
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Heesen, Philipp [Verfasser], Arnold [Akademischer Betreuer] Janssen, and Helmut [Akademischer Betreuer] Finner. "Adaptive step up tests for the false discovery rate (FDR) under independence and dependence / Philipp Heesen. Gutachter: Arnold Janssen ; Helmut Finner." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2015. http://d-nb.info/1064694039/34.

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Inamdar, Arati Ajinkya. "Discovery of a nitric oxide-dependent response and a functional analysis of genes regulating the response in a Drosophila model of Parkinson's disease." Thesis, [Tuscaloosa, Ala. : University of Alabama Libraries], 2009. http://purl.lib.ua.edu/93.

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"A Tool to Reduce Defects due to Dependencies between HTML5, JavaScript and CSS3." Master's thesis, 2016. http://hdl.handle.net/2286/R.I.39436.

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abstract: One of the most common errors developers make is to provide incorrect string identifiers across the HTML5-JavaScript-CSS3 stack. The existing literature shows that a significant percentage of defects observed in real-world codebases belong to this category. Existing work focuses on semantic static analysis, while this thesis attempts to tackle the challenges that can be solved using syntactic static analysis. This thesis proposes a tool for quickly identifying defects at the time of injection due to dependencies between HTML5, JavaScript, and CSS3, specifically in syntactic errors in string identifiers. The proposed solution reduces the delta (time) between defect injection and defect discovery with the use of a dedicated just-in-time syntactic string identifier resolution tool. The solution focuses on modeling the nature of syntactic dependencies across the stack, and providing a tool that helps developers discover such dependencies. This thesis reports on an empirical study of the tool usage by developers in a realistic scenario, with the focus on defect injection and defect discovery times of defects of this nature (syntactic errors in string identifiers) with and without the use of the proposed tool. Further, the tool was validated against a set of real-world codebases to analyze the significance of these defects.<br>Dissertation/Thesis<br>Masters Thesis Computer Science 2016
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Clarke, Sandra Jane. "The performance of multiple hypothesis testing procedures in the presence of dependence." 2010. http://repository.unimelb.edu.au/10187/7284.

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Hypothesis testing is foundational to the discipline of statistics. Procedures exist which control for individual Type I error rates and more global or family-wise error rates for a series of hypothesis tests. However, the ability of scientists to produce very large data sets with increasing ease has led to a rapid rise in the number of statistical tests performed, often with small sample sizes. This is seen particularly in the area of biotechnology and the analysis of microarray data. This thesis considers this high-dimensional context with particular focus on the effects of dependence on existing multiple hypothesis testing procedures.<br>While dependence is often ignored, there are many existing techniques employed currently to deal with this context but these are typically highly conservative or require difficult estimation of large correlation matrices. This thesis demonstrates that, in this high-dimensional context when the distribution of the test statistics is light-tailed, dependence is not as much of a concern as in the classical contexts. This is achieved with the use of a moving average model. One important implication of this is that, when this is satisfied, procedures designed for independent test statistics can be used confidently on dependent test statistics.<br>This is not the case however for heavy-tailed distributions, where we expect an asymptotic Poisson cluster process of false discoveries. In these cases, we estimate the parameters of this process along with the tail-weight from the observed exceedences and attempt to adjust procedures. We consider both conservative error rates such as the family-wise error rate and more popular methods such as the false discovery rate. We are able to demonstrate that, in the context of DNA microarrays, it is rare to find heavy-tailed distributions because most test statistics are averages.
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25

"Multi-omics network analysis to discover novel type 2 diabetes related genes." 2013. http://library.cuhk.edu.hk/record=b5884454.

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Gao, Zhibo.<br>Thesis (Ph.D.)--Chinese University of Hong Kong, 2013.<br>Includes bibliographical references (leaves 147-157).<br>Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web.<br>Abstract also in Chinese.
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26

Kitt, Alexander. "Manipulating graphene's lattice to create pseudovector potentials, discover anomalous friction, and measure strain dependent thermal conductivity." Thesis, 2014. https://hdl.handle.net/2144/15101.

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Graphene is a single atomic sheet of graphite that exhibits a diverse range of unique properties. The electrons in intrinsic graphene behave like relativistic Dirac fermions; graphene has a record high Young's modulus but extremely low bending rigidity; and suspended graphene exhibits very high thermal conductivity. These properties are made more intriguing because with a thickness of only a single atomic layer, graphene is both especially affected by its environment and readily manipulated. In this dissertation the interaction between graphene and its environment as well as the exciting new physics realized by manipulating graphene's lattice are investigated. Lattice manipulations in the form of strain cause alterations in graphene's electrical dispersion mathematically analogous to the vector potential associated with a magnetic field. We complete the standard description of the strain-induced vector potential by explicitly including the lattice deformations and find new, leading order terms. Additionally, a strain engineered device with large, localized, plasmonically enhanced pseudomagnetic fields is proposed to couple light to pseudomagnetic fields. Accurate strain engineering requires a complete understanding of the interactions between a two dimensional material and its environment, particularly the adhesion and friction between graphene and its supporting substrate. We measure the load dependent sliding friction between mono-, bi-, and trilayer graphene and the commonly used silicon dioxide substrate by analyzing Raman spectra of circular, graphene sealed microchambers under variable external pressure. We find that the sliding friction for trilayer graphene behaves normally, scaling with the applied load, whereas the friction for monolayer and bilayer graphene is anomalous, scaling with the inverse of the strain in the graphene. Both strain and graphene's environment are expected to affect the quadratically dispersed out of plane acoustic phonon. Although this phonon is believed to provide the majority of graphene's very high thermal conductivity, its contributions have never been isolated. By measuring strain and pressure dependent thermal conductivity, we gain insight into the mechanism of graphene's thermal transport.
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Hakki, Tarek [Verfasser]. "Development of efficient cytochrome P450-dependent whole-cell biotransformation reactions for steroid hydroxylation and drug discovery / von Tarek Hakki." 2008. http://d-nb.info/1007545569/34.

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Samuelsen, Andrew Ira. "Transformation of tobacco with the yeast FRE1 and FRE2 genes : characterization of transformants and discovery of a temperature-dependent morphological mutant." Thesis, 1996. http://hdl.handle.net/1957/34329.

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A key mechanism utilized by plants to make iron (Fe) available for uptake is the reduction of Fe(III) to Fe(II) via an inducible, plasma membrane-bound Fe(III) reductase. Genes encoding such enzymes have not yet been isolated from plants; however, two Fe(III) reductases have been cloned from yeast. FRE1 and FRE2 account for the total membrane-associated Fe(III) reductase activity in Saccharomyces cerevisiae. If yeast reductase genes could be expressed in a plant system, root Fe(III) reduction may be enhanced, leading to a decrease in Fe chlorosis in transgenic plants. FRE1 and FRE2 were introduced into tobacco via Agrobacterium-mediated transformation. Fe(III) reductase activity was measured in homozygous transformants containing FRE1, FRE2, or both. The highest Fe(III) reduction levels were found in lines containing both FRE1 and FRE2. Liquid reductase assays showed three to four times more Fe(III) reduction in these transformants as compared to controls, and visual plate assays showed reduction along the entire length of the roots. One FRE1 containing line initially exhibited chlorosis on medium with low Fe at pH 7.5, but later recovered. Other transformants and the control remained chlorotic. Agrobacterium-mediated transformation often produces mutant phenotypes. A temperature-dependent morphological mutant was found among the progeny of tobacco transformed by Agrobacterium. The mutation is recessive and is expressed at low temperature (21��C). Mutant characteristics include formation of thick, narrow leaves with abnormal mesophyll cells and near absence of apical dominance. Also in the greenhouse (21-23��C), most plants remain vegetative, and the few flowers that are formed have petaloid stamens. High temperature (30��C) reverses the mutant phenotype, with formation of normal leaves and restoration of apical dominance. However, many flowers still have petaloid stamens. This mutant shares several phenotypic characteristics with transgenic tobacco plants overexpressing maize and Arabidopsis homeodomain proteins.<br>Graduation date: 1997
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Hillertz, Per [Verfasser]. "Advances in fragment-based drug discovery : studies of cAMP-dependent protein-kinase A using X-ray crystallography, surface plasmon resonance and high compound concentration assays / presented by Per Hillertz." 2010. http://d-nb.info/1003221165/34.

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