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Journal articles on the topic 'Derivatives of bacteria'

Author: Grafiati

Published: 5 June 2025

Last updated: 1 August 2025

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1

Stratford, Richard, Nicola D. McKelvie, Nicky J. Hughes та ін. "Optimization of Salmonella enterica Serovar Typhi ΔaroC ΔssaV Derivatives as Vehicles for Delivering Heterologous Antigens by Chromosomal Integration and In Vivo Inducible Promoters". Infection and Immunity 73, № 1 (2005): 362–68. http://dx.doi.org/10.1128/iai.73.1.362-368.2005.

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ABSTRACT Novel candidate live oral vaccines based on a Salmonella enterica serovar Typhi ZH9 (Ty2 ΔaroC ΔssaV) derivative that directed the expression of either the B subunit of Escherichia coli heat-labile toxin or hepatitis B virus core antigen from the bacterial chromosome using the in vivo inducible ssaG promoter were constructed. The levels of attenuation of the two S. enterica serovar Typhi ZH9 derivatives were similar to that of the parent as assessed by measuring the replication of bacteria within human macrophage-like U937 cells. The expression of heterologous antigen in the respectiv

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Kmal, Rafid Q., Shaimaa A. Behget, and Meaad N. Husean. "Synthesis and Characterization of Formazan Derivatives from Schiff’s Base and Studying their Biological Activity." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 12, no. 02 (2022): 782–88. http://dx.doi.org/10.25258/ijddt.12.2.56.

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A group of substituted formazine derivatives was prepared through several steps where the first step was the preparation of compound (1) by reacting chloroacetyl chloride with 2-aminopyrimidine, and the second step was the reaction of compound (1) with hydrazine hydrate to obtain the derivative (2) and in the third step was prepared Schiff’s base (3) by reaction of derivative (2) with para-dimethyl benzaldehyde and then a number of formazine derivatives were synthesized by reaction of derivative (3) with a number of substituted aromatic amines. The newly prepared derivatives are distinguished

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Bereczki, Ilona, Zsolt Szűcs, Gyula Batta, et al. "The First Dimeric Derivatives of the Glycopeptide Antibiotic Teicoplanin." Pharmaceuticals 15, no. 1 (2022): 77. http://dx.doi.org/10.3390/ph15010077.

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Various dimeric derivatives of the glycopeptide antibiotic teicoplanin were prepared with the aim of increasing the activity of the parent compound against glycopeptide-resistant bacteria, primarily vancomycin-resistant enterococci. Starting from teicoplanin, four covalent dimers were prepared in two orientations, using an α,ω-bis-isothiocyanate linker. Formation of a dimeric cobalt coordination complex of an N-terminal L-histidyl derivative of teicoplanin pseudoaglycone has been detected and its antibacterial activity evaluated. The Co(III)-induced dimerization of the histidyl derivative was

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Shalini, Kumar Gautam Surendra, Srivastava Shobhit, and Kumar Gupta Sujeet. "Indole: A Versatile Heterocyclic." Chemistry Research Journal 6, no. 4 (2021): 17–30. https://doi.org/10.5281/zenodo.11665549.

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<strong>Abstract </strong>Indole is a heterocyclic compound comprise of benzene and pyrrole ring. The Indole nucleus plays an important role in medicinal chemistry to synthesized a series of multiple biological active derivatives such as Anti-inflammatory, Anti-proliferative, Anti-bacterial, Antidiabetic, Antioxidant, Antifungal, Anticancer etc. Various indole derivatives and substituents are mention in article. These derivative of carbazole are tested for varying pharmacological activities. The main motive of the review article to describe their pharmacological action and activities against d

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5

A Alam, Mohammad. "Antibacterial pyrazoles: tackling resistant bacteria." Future Medicinal Chemistry 14, no. 5 (2022): 343–62. http://dx.doi.org/10.4155/fmc-2021-0275.

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Bacterial resistance to antibiotics threatens our progress in healthcare, modern medicine, food production and ultimately life expectancy. Antibiotic resistance is a global concern, which spreads rapidly across borders and continents due to rapid travel of people, animals and goods. Derivatives of metabolically stable pyrazole nucleus are known for their wide range of pharmacological properties, including antibacterial activities. This review highlights recent reports of pyrazole derivatives targeting different bacterial strains focusing on the drug-resistant variants. Pyrazole derivatives tar

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Honeyman, Laura, Mohamed Ismail, Mark L. Nelson, et al. "Structure-Activity Relationship of the Aminomethylcyclines and the Discovery of Omadacycline." Antimicrobial Agents and Chemotherapy 59, no. 11 (2015): 7044–53. http://dx.doi.org/10.1128/aac.01536-15.

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ABSTRACTA series of novel tetracycline derivatives were synthesized with the goal of creating new antibiotics that would be unaffected by the known tetracycline resistance mechanisms. New C-9-position derivatives of minocycline (the aminomethylcyclines [AMCs]) were tested forin vitroactivity against Gram-positive strains containing known tetracycline resistance mechanisms of ribosomal protection (Tet M inStaphylococcus aureus,Enterococcus faecalis, andStreptococcus pneumoniae) and efflux (Tet K inS. aureusand Tet L inE. faecalis). A number of aminomethylcyclines with potentin vitroactivity (MI

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Kawsar, Sarkar M. A., Samia S. B. S. Nishat, Mohammad A. Manchur та Yasuhiro Ozeki. "Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening". International Letters of Chemistry, Physics and Astronomy 64 (лютий 2016): 95–105. http://dx.doi.org/10.18052/www.scipress.com/ilcpa.64.95.

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A novel series of benzenesulfonyl derivatives of methyl α-D-glucopyranoside (1) were synthesized by reacting benzenesulfonyl chloride in pyridine followed by direct acylation method to yield 6-O-benzenesulfonyl derivative (2). In order to obtain newer products for antibacterial evaluation studies, the 6-O-benzenesulfonyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-11) containing a wide variety of functionalities in a single molecular framework. All the synthesized compounds have been confirmed by IR,1H NMR and elemental analysis. These newly synthesized co

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Kawsar, Sarkar M. A., Samia S. B. S. Nishat, Mohammad A. Manchur та Yasuhiro Ozeki. "Benzenesulfonylation of Methyl α-D-Glucopyranoside: Synthesis, Characterization and Antibacterial Screening". International Letters of Chemistry, Physics and Astronomy 64 (15 лютого 2016): 95–105. http://dx.doi.org/10.56431/p-637009.

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A novel series of benzenesulfonyl derivatives of methyl α-D-glucopyranoside (1) were synthesized by reacting benzenesulfonyl chloride in pyridine followed by direct acylation method to yield 6-O-benzenesulfonyl derivative (2). In order to obtain newer products for antibacterial evaluation studies, the 6-O-benzenesulfonyl derivative was further transformed to a series of 2,3,4-tri-O-acyl derivatives (3-11) containing a wide variety of functionalities in a single molecular framework. All the synthesized compounds have been confirmed by IR, 1H NMR and elemental analysis. These newly synthesized c

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9

Hassan, Huda Salman, and Sana Hitur Awad. "SYNTHESIS AND CHARACTERIZATION OF NEW SCHIFF BASES FOR CHITOSAN AND STUDY THEIR ANTIMICROBIAL ACTIVITY." Iraqi Journal of Market Research and Consumer Protection 15, no. 2 (2023): 192–206. http://dx.doi.org/10.28936/jmracpc15.2.2023.(19).

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Biopolymers and their derivatives have a wide range applications due to their biodegradability, low toxicity, and biocompatibility. The current study aimed to develop and characterize the unique Schiff ,s chitosan bases by conjugation the chitosan with different aldehydes under acidic conditions to form Schiff ,s chitosan bases which reacted with a plant extract derivative (capsaicin) to get new Schiff ,s derivatives. The resulting compounds were diagnosed by using fourier transform infrared (FT-IR), as well as nuclear magnetic resonance(1H-NMR). The biological activity of the new derivatives

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10

Pandian Amuthavalli, Ayyachamy, Babu Prakash, David Edison, and Rajendran Velmurugan. "Synthesis, Spectral Analysis, Molecular Docking and Biological Evaluation of Cyclohepta[b]indole Derivatives." Croatica chemica acta 92, no. 3 (2019): 347–56. http://dx.doi.org/10.5562/cca3375.

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A new series of specifically substituted cyclohepta[b]indole derivatives from the precursor thiophen-2-ylmethylene has been synthesized. The structures of synthesized derivatives were established by spectral and elemental analyses. The docking studies with protein kinase CK2 was performed, derivative 6c exhibited the most excellent glide and E model score of –7.61 and –58.27, respectively. In-vitro anticancer activity against cervical cancer cell line (HeLa) was studied. The IC50 values were compared with the standard drug Ellipticine. Compounds 5c, 6c and 6d showed better IC50 value when comp

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Sultan Alwan, Ensaf, and Rafat Milad Mohareb. "Synthesis of bioactive heterocyclic compounds using camphor." Bulletin of the Chemical Society of Ethiopia 38, no. 4 (2024): 1069–76. http://dx.doi.org/10.4314/bcse.v38i4.20.

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The aim of the work was to synthesize novel heterocyclic compounds derived from camphor with antibacterial activity. The pyridazine, xanthene, pyranothiazole, pyridinothiazole, thiophene and pyrazole derivatives were produced from 4,11,11-trimethyl-9-phenyl-7-(2-phenylhydrazono)-3,4,5,6,7,9-hexahydro-1H-1,4-methanoxanthen-8(2H)-one (1). Thiophene derivatives 6a,b were produced according to the Gewald’s reaction for thiophene synthesis. On the other hand, pyranothiazol derivatives 8a,b were synthesized by the multicomponent reactions between xanthene derivative 5, benzaldehyde and ethylcyanoace

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12

Li, Chunhong, Matthew R. Lewis, Amy B. Gilbert, et al. "Antimicrobial Activities of Amine- and Guanidine-Functionalized Cholic Acid Derivatives." Antimicrobial Agents and Chemotherapy 43, no. 6 (1999): 1347–49. http://dx.doi.org/10.1128/aac.43.6.1347.

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ABSTRACT Compounds in a series of cholic acid derivatives, designed to mimic the activities of polymyxin B and its derivatives, act as both potent antibiotics and effective permeabilizers of the outer membranes of gram-negative bacteria. Some of these compounds rival polymyxin B in antibacterial activity against gram-negative bacteria and are also very active against gram-positive organisms. Other compounds interact synergistically with hydrophobic antibiotics to inhibit bacterial growth.

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13

Acharyulu, S. Raghunadh, N. Srinivasu, Sivaranjani Jampala, and Arundhuthi M. "An Exquisite Design Process and Impacting Synthesis of 2-methyl Nicotinamide Derivatives and their Anti-bacterial Activity Closet to Fab I Inhibitors." Oriental Journal Of Chemistry 40, no. 5 (2024): 1250–60. http://dx.doi.org/10.13005/ojc/400506.

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Synthesis of “5-(2,5-difluoro-4-((4-methylpiperazin-1-yl) methyl) phenyl)-N-(2-methoxybenzyl)-2-ethyl nicotinamide and 2-fluoro-4-(6-fluoro pyridine-2-yl)-6-(4-methyl piperazine-1-yl)” benzaldehyde derivatives has been developed using the 4−bromo−2,5 –difluoro benzaldehyde and 4−bromo−2,6−diflouro benzaldehyde and further this chemical to prepare the various novel derivatives. Synthesized compounds have been characterized using FTIR, 1H-NMR, 13CNMR etc. Such developed molecules are novel, cost-effective, and can be prepared by industrially viable methods. As a result of the fewer reaction step

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14

Rotem, Shahar, Inna Radzishevsky, and Amram Mor. "Physicochemical Properties That Enhance Discriminative Antibacterial Activity of Short Dermaseptin Derivatives." Antimicrobial Agents and Chemotherapy 50, no. 8 (2006): 2666–72. http://dx.doi.org/10.1128/aac.00030-06.

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ABSTRACT Antimicrobial peptides are widely believed to exert their effects by nonspecific mechanisms. We assessed the extent to which physicochemical properties can be exploited to promote discriminative activity by manipulating the N-terminal sequence of the 13-mer dermaseptin derivative K4-S4(1-13) (P). Inhibitory activity determined in culture media against 16 strains of bacteria showed that when its hydrophobicity and charge were changed, P became predominantly active against either gram-positive or gram-negative bacteria. Thus, conjugation of various aminoacyl-lysin moieties (e.g., aminoh

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15

Kang, Sae-Ryung, Dinh-Huy Nguyen, Su Woong Yoo, and Jung-Joon Min. "Bacteria and bacterial derivatives as delivery carriers for immunotherapy." Advanced Drug Delivery Reviews 181 (February 2022): 114085. http://dx.doi.org/10.1016/j.addr.2021.114085.

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16

Maryam Methaq Najm and Hanan Faleh Mohsein. "Synthesis, Antibacterial Evaluation and Study Molecular Docking of New derivatives from sulfapyridine." Journal of Kufa for Chemical Sciences 3, no. 3 (2024): 134–49. https://doi.org/10.36329/jkcm/2024/v3.i3.15832.

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Sulfa pyridine is a sulfa-derived antibiotic. It works to inhibit the activity and reproduction of bacterial cells, by inhibiting the production of some enzymes that bacteria need for their growth and activity. Therefore, in this research, we decided to increase the effectiveness of the Sulfa pyridine compound by adding some groups such as azomethine, as well as preparing some derivatives of thiazolidinone and derivatives , thiazine, hydroquinazolone, and oxazepine, Then evaluating the effectiveness of some prepared derivatives against two types of gram-negative and gram-positive bacteria, suc

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17

Hurtová, Martina, Kristýna Káňová, Simona Dobiasová, et al. "Selectively Halogenated Flavonolignans—Preparation and Antibacterial Activity." International Journal of Molecular Sciences 23, no. 23 (2022): 15121. http://dx.doi.org/10.3390/ijms232315121.

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A library of previously unknown halogenated derivatives of flavonolignans (silybins A and B, 2,3-dehydrosilybin, silychristin A, and 2,3-dehydrosilychristin A) was prepared. The effect of halogenation on the biological activity of flavonolignans was investigated. Halogenated derivatives had a significant effect on bacteria. All prepared derivatives inhibited the AI-2 type of bacterial communication (quorum sensing) at concentrations below 10 µM. All prepared compounds also inhibited the adhesion of bacteria (Staphyloccocus aureus and Pseudomonas aeruginosa) to the surface, preventing biofilm f

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18

Neves, Ana Rita, Fernando Durães, Joana Freitas-Silva, et al. "Derivatives of Trimethoxybenzoic Acid and Gallic Acid as Potential Efflux Pump Inhibitors: In Silico and In Vitro Studies." International Journal of Molecular Sciences 23, no. 22 (2022): 14468. http://dx.doi.org/10.3390/ijms232214468.

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The overexpression of efflux pumps is one of the strategies used by bacteria to resist antibiotics and could be targeted to circumvent the antibiotic crisis. In this work, a series of trimethoxybenzoic acid derivatives previously described as antifouling compounds was explored for potential antimicrobial activity and efflux pump (EP) inhibition. First, docking studies on the acridine resistance proteins A and B coupled to the outer membrane channel TolC (AcrAB-TolC) efflux system and a homology model of the quinolone resistance protein NorA EP were performed on 11 potential bioactive trimethox

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Sonawane, Vikas D., Raghunath B. Bhosale, Gajanan S. Rashinkar, and Kailas D. Kailas D. "GREEN SYNTHESIS AND BIOLOGICAL SCREENING OF IMIDAZO [2,1-B] THIAZOLE PYRIMIDINES AS POTENT ANTI-BACTERIAL AGENTS." YMER Digital 21, no. 07 (2022): 280–95. http://dx.doi.org/10.37896/ymer21.07/21.

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A series of Imidazo[2,1-b]thiazole pyrmidine derivatives (3a-g-) were designed, synthesized from imidazo[2,1-b]thiazole chalcone derivatives. (2a-g) and Urea in PEG-400 and evaluated for their anti-bacterial potency. Characterization of newly synthesized compounds was done using IR and 1H NMR and Mass spectroscopy. Further Imidazo [2,1-b]thiazole pyrimidine derivatives were subjected to check their anti-bacterial activities against four different strains, viz two Gram +ve bacteria Staphylococcus aureus & Bacillus subtilis and two Gram -ve bacteria Escherichia coli & Pseudomonas aerugin

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Pal, Pinki. "Recent Advancements in the Synthesis of Pyrimidine-based Analogs as Anti-bacterial Agents: A Review." INDIAN JOURNAL OF HETEROCYCLIC CHEMISTRY 34, no. 04 (2024): 489. https://doi.org/10.59467/ijhc.2024.34.489.

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One of the most effective tools for preventing bacterial strain-caused infections is anti-microbial agents. Increased microbial resistance to anti-microbial treatments has recently become a significant health concern, necessitating the development of innovative, potent, and safe anti-microbial agents. Pyrimidine derivatives have occupied a unique position in the field of medicinal chemistry. The inclusion of the pyrimidine nucleus in synthetic drugs is crucial in the quest for novel medications. The multidirectional biological actions of pyrimidine and its derivatives have been extensively stu

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Tarantino, Paul M., Chengxin Zhi, George E. Wright, and Neal C. Brown. "Inhibitors of DNA Polymerase III as Novel Antimicrobial Agents against Gram-Positive Eubacteria." Antimicrobial Agents and Chemotherapy 43, no. 8 (1999): 1982–87. http://dx.doi.org/10.1128/aac.43.8.1982.

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ABSTRACT 6-Anilinouracils are selective inhibitors of DNA polymerase III, the enzyme required for the replication of chromosomal DNA in gram-positive bacteria (N. C. Brown, L. W. Dudycz, and G. E. Wright, Drugs Exp. Clin. Res. 12:555–564, 1986). A new class of 6-anilinouracils based on N-3 alkyl substitution of the uracil ring was synthesized and analyzed for activity as inhibitors of the gram-positive bacterial DNA polymerase III and the growth of gram-positive bacterial pathogens. Favorable in vitro properties of N-3-alkyl derivatives prompted the synthesis of derivatives in which the R grou

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Naji, Amel Mohson, Ahmed Mutanabbi Abdula, Olfat A. Nief, and Ebtihal K. Abdullah. "Synthesis, Characterization, Antimicrobial and Molecular Docking Study of Benzooxadiazole Derivatives." Chemistry & Chemical Technology 16, no. 1 (2022): 25–33. http://dx.doi.org/10.23939/chcht16.01.025.

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In this study, a series of new1,2,5-oxadiazole compounds derived from 4-chloro-7-nitro-benzo 1,2,5-oxadiazole was synthesized using different organic procedures. The resulting derivatives were chemically characterized and their structures were confirmed by FT-IR and NMR analysis. All the compounds were also evaluated for their antibacterial and antifungal activity against four types of pathogenic bacteria: S.aureus, S.epidermidis (as gram-negative bacteria), E.coli, Klebsiella spp. (as gram-positive bacteria) and the fungus Candida albicans using the agar well diffusion method. The synthesized

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Sayali, S. Ingale, P. Wadekar Murlidhar, H. Murhekar Gopalkrushna, and G. Thakare Vaibhao. "Studies on synthesis, spectral characterization and antimicrobial evaluation of some 1,3,5-Triazine derivatives." Int. Res. Journal of Science & Engineering, 2023 11, no. 6 (2023): 249–64. https://doi.org/10.5281/zenodo.10523784.

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In this work, new s-triazine derivatives were synthesized, characterized and screened to study the antimicrobial activities. Nowdays synthesis, characterization, and antimicrobial studies of some 1,3,5-Triazine derivatives is having importance due to very diverse medicinal properties of these compounds. The characterization techniques included are thermal and antimicrobial characterization methods used to characterize newly synthesized 1,3,5 triazine derivatives.  The structural characterizations include X-ray diffraction (XRD), Fourier Transform IR Spectroscopy (FTIR) and some impor

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Swellmeen, Lubna, Amal Uzrail, Rand Shahin, and Yusuf AL-Hiari. "Synthesis of Fluoroquinolones Derivatives as Antimicrobial Agents." Oriental Journal Of Chemistry 35, no. 4 (2019): 1248–53. http://dx.doi.org/10.13005/ojc/350401.

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Fluoroquinolones are well known to have an anti-infective action. In the present study we described the synthesis of novel florouquinolones derivative as antimicrobial agent. The biological test highlighted a good inhibitory activity for the 7-Chloro-1-Alkyl-6-fluoro-8-nitro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid derived synthons especially against pathogenic Gram-negative bacteria (Pseudomonas aeruginosa) and Gram-positive bacteria (Staphylococcus aureus and Streptococcus agalactiae). The binding interactions were monitored and could explain the good inhibitory activity of the synthesiz

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Kavitha, .S, B. Baijika., Mathew Cyril, K. P. Jithamol, and Purandharan Aswani. "A Review of Coumarin as Antibacterial Agent." Journal of Advances in Pharmaceutical Sciences 1, no. 2 (2023): 32–44. https://doi.org/10.5281/zenodo.10089048.

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<i>Coumarin is the heterocyclic compound formed from benzene and pyrone ring containing oxygen atom. Coumarin derivatives have different biological activities such as anticancer, antimicrobial, antimalarial, antioxidant, antiviral, anti-inflammatory analgesic, antianxiety etc. The synthesised coumarin derivatives were screened for their anti-bacterial activity by means of Disc-well diffusion assay against Gram-positive bacteria and Gram-negative strains. The compounds proved that it is moderate to significant anti-bacterial activity. This review is based on the synthesis of various coumar

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Adnan, Shaimaa, and Abdullah Shakir. "Synthesis and Characterization of some new Formazan Derivatives from 2-Amino-4-Hydroxy-6-Methyl Pyrimidine and Study the Biological Activity (Anti-Bacteria and Anti-Cancer)." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 11, no. 01 (2020): 53–59. http://dx.doi.org/10.25258/ijpqa.11.1.8.

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This study involves a synthesis of some formazan derivatives starting from react chloro acetyl chlorid with 2-amino-4-hydroxy-6-methyl pyrimidine to gate compound (a), (a) react with hydrazine hydrate to give compound (b) also (b) react with 3-4-dimethoxy benzaldehyd to product Schiff base derivative (c) then (c) react with deferent amin derivatives to get formazan derivatives. All these compounds characterized by 13C-NMR, fourier transform infrared spectroscopy (FTIR), 1HMNR. After that, we study the biological activity for all formazan derivatives toward two different kinds of bacteria and a

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Ng, Keng Tiong, John D. Perry, Emma C. L. Marrs, Sylvain Orenga, Rosaleen J. Anderson, and Mark Gray. "Synthesis and Antimicrobial Activity of Phosphonopeptide Derivatives Incorporating Single and Dual Inhibitors." Molecules 25, no. 7 (2020): 1557. http://dx.doi.org/10.3390/molecules25071557.

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In diagnostic microbiology, culture media are widely used for detection of pathogenic bacteria. Such media employ various ingredients to optimize detection of specific pathogens such as chromogenic enzyme substrates and selective inhibitors to reduce the presence of commensal bacteria. Despite this, it is rarely possible to inhibit the growth of all commensal bacteria, and thus pathogens can be overgrown and remain undetected. One approach to attempt to remedy this is the use of “suicide substrates” that can target specific bacterial enzymes and selectively inhibit unwanted bacterial species.

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Huda ahmed younis and Raheem Jameel Mahesein. "Synthesis and characterization A derivative of levofloxacin and a study of its bacteriostatic activity." Journal of Kufa for Chemical Sciences 3, no. 1 (2023): 97–125. http://dx.doi.org/10.36329/jkcm/2023/v3.i1.11699.

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This study includes two newly synthesized prodrugs of Levofloxacin derivatives mono and dipeptide H2, where was the Synthesized monoPeptide as Levofloxacin-Histadine (L-H), as well as dipeptide H6 as Synthesis of diPeptide (phenylalanine- levofloxacin (GPA-L), using a Levofloxacin substituted. Spectroscopic data were studied for two derivative compounds H2 and H6 and reactivity indices were characterized using techniques FT-IR, 1H-NMR, and 13C-NMR. All the newly produced derivative compounds H2 and H6 have FT-IR spectra that share similarities in certain fingerprint-like bands and other bands.

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Israpilova, A. I., A. A. Adieva, A. M. Jafarova, G. M. Abakarov, and I. V. Amirkhanova. "ANTIBACTERIAL PROPERTIES OF ORGANOTELLURIUM COMPOUNDS." Problems of Biological, Medical and Pharmaceutical Chemistry 27, no. 2 (2024): 31–39. http://dx.doi.org/10.29296/25877313-2024-02-04.

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Introduction. Antimicrobial resistance in bacteria has become a global challenge for public health systems. Bacteria that pose the greatest threat to human health due to their increasing resistance to antibiotics include Escherichia coli, Staphylococcus aureus and Salmonella spp. The purpose of the work is to study the antibacterial properties of three tellurium derivatives against infections caused by Staphylococcus, Escherichia coli and Salmonella. Material and methods. The object of study is heterocyclic tellurium derivatives. A comparative analysis of the antibacterial properties of the sy

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WAITE, JOY G., and AHMED E. YOUSEF. "Enhanced Inactivation of Foodborne Pathogenic and Spoilage Bacteria by FD&C Red No. 3 and Other Xanthene Derivatives during Ultrahigh Pressure Processing." Journal of Food Protection 71, no. 9 (2008): 1861–67. http://dx.doi.org/10.4315/0362-028x-71.9.1861.

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Variability among microorganisms in barotolerance has been demonstrated at genus, species, and strain levels. Identification of conditions and additives that enhance the efficacy of ultrahigh pressure (UHP) against important foodborne micro-organisms is crucial for maximizing product safety and stability. Preliminary work indicated that FD&C Red No. 3 (Red 3), a xanthene derivative, was bactericidal and acted synergistically with UHP against Lactobacillus spp. The objective of this study was to determine the antimicrobial efficacy of Red 3 and other xanthene derivatives, alone and combined

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Yarullina, L. G., J. N. Kalatskaja, E. A. Cherepanova, et al. "Prospects to Improving Biological Activity of Agricultural Formulations Based on Bacteria of the Genus <i>Bacillus</i> and Chitosan Nanocomposites." Прикладная биохимия и микробиология 59, no. 5 (2023): 427–39. http://dx.doi.org/10.31857/s0555109923050185.

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The review examines the properties of endophytic bacteria of the genus Bacillus as objects of biocontrol, prospects to expand the spectrum of their protective action based on complexes with chitosan derivatives. The mechanisms of direct and indirect effects of bacteria on the protective potential of plants are described, the role of the pro-/antioxidant system in the formation of systemic protective reactions is analyzed. The immunostimulating properties of chitosan derivatives and its modifications with organic molecules and metal nanoparticles are analyzed. The prospects of using Bacillus sp

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Trizna, E. Yu, E. N. Khakimullina, L. Z. Latypova, et al. "Thio Derivatives of 2(5H)-Furanone As Inhibitors against Bacillus subtilis Biofilms." Acta Naturae 7, no. 2 (2015): 102–7. http://dx.doi.org/10.32607/20758251-2015-7-2-102-107.

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Gram-positive bacteria cause a wide spectrum of infectious diseases, including nosocomial infections. While in the biofilm, bacteria exhibit increased resistance to antibiotics and the human immune system, causing difficulties in treatment. Thus, the development of biofilm formation inhibitors is a great challenge in pharmacology. The gram-positive bacterium Bacillus subtilis is widely used as a model organism for studying biofilm formation. Here, we report on the effect of new synthesized 2(5Н)-furanones on the biofilm formation by B.subtilis cells. Among 57 compounds tested, sulfur-containin

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Unde, Pradip J., Kiran D. Dhawale, Satish G. Parte, and Limbraj R. Patil. "Microwave Assisted Synthesis of Some Novel Pyrimidine Derivative and Screening for their Biological Activity." Asian Journal of Organic & Medicinal Chemistry 5, no. 4 (2020): 289–94. http://dx.doi.org/10.14233/ajomc.2020.ajomc-p292.

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A substituted pyrimidine derivatives were synthesized from chalcone of 3-acetyl-2,5-dimethyl thiophene with corresponding active aldehyde in microwave oven. The newly synthesized compounds were characterized by TLC, IR, 1H NMR, 13C NMR spectral analysis. Pyrimidine derivative were screened for their antibacterial activity in vitro by the disk diffusion assay against two Gram-positive and two Gram-negative bacteria and then the minimum inhibitory concentration (MIC) was carried with the reference of standard drugs amoxicillin, ampicillin and ciprofloxacin. The pyrimidine derivatives shows bette

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M. Juaila, Karrar, and Nasreen R. Jber. "Synthesis, Characterization and Evaluation of the Antimicrobial Activity of a New [1,2,4] Triazolo [3,4-B] [1,3,4] Thiadiazoles Derivatives." Al-Nahrain Journal of Science 27, no. 3 (2024): 1–8. https://doi.org/10.22401/anjs.27.3.01.

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In this study, synthesis of [D-H] via reaction of compound [C] with p-alkoxybenzaldehyde. The derivative [C] that produces from reaction the 4-amino-5-(4-aminophenyl)-4H-1,2,4-triazole-3-thiol with phosphory l chloride. The synthesized derivatives are characterized by 1HNMR and FTIR spectroscopies. The antibacterial activity of the obtained thiadiazol derivatives [D-H] was screened against Gram-positive bacteria viz.(Staphylococcus aureus, Bacillus subtilis) and Gram-negative bacteria viz. (Escherichia coli) by disc diffusion method, the results showed that compound [H]has the highest activity

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Gao, Kun, Yukun Qin, Song Liu, et al. "Synthesis, Characterization, and Anti-Phytopathogen Evaluation of 6-Oxychitosan Derivatives Containing N-Quaternized Moieties in Its Backbone." International Journal of Polymer Science 2018 (August 1, 2018): 1–7. http://dx.doi.org/10.1155/2018/3970142.

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The structure modification of chitosan has great application potential. 6-Oxychitosan was prepared by specially oxidizing the C6-OH of chitosan, then 6-oxychitosan was reacted with three kinds of aldehydes to prepare N-quaternized 6-oxychitosan derivatives in this paper. The derivatives were characterized by FT-IR, NMR, and elemental analysis. The antimicrobial activity of these derivatives was tested against two common plant-threatening fungi and three plant disease bacteria. The results showed that N-quaternized 6-oxychitosan derivatives had good water-solubility and excellent antimicrobial

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Halawa, Ahmed H., Ahmed H. Bedair, Ahmed M. El-Agrody, et al. "Synthesis and biological activities of new bis-indole derivatives via microwave irradiation." Zeitschrift für Naturforschung B 72, no. 9 (2017): 639–46. http://dx.doi.org/10.1515/znb-2017-0039.

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AbstractThree new series of bis-indole derivatives were synthesized based onp-phenylenediamine (2–4, 5and6) and 4,4′-ethylenedianiline moieties (7–9) using facile and efficient condensation of three positional isomeric indole-carboxaldehyde derivatives (1a–c) with bifunctional amines upon microwave irradiation. The symmetric dimeric indole derivatives2–4as well as non-symmetric analogues5and6were obtained byin situcondensation of the respective positional 3-, 2- and 5-isomeric indole-carboxaldehydes withp-phenylenediamine, while compounds7–9resulted from respective condensation based on 4,4′-e

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T. Abduljabbar, Tariq, and Mohammed K. Hadi. "Synthesis, Characterization and Antibacterial Evaluation of Some Coumarin Derivatives." Iraqi Journal of Pharmaceutical Sciences ( P-ISSN: 1683 - 3597 , E-ISSN : 2521 - 3512) 30, no. 1 (2021): 249–57. http://dx.doi.org/10.31351/vol30iss1pp249-257.

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Coumarin derivatives have shown different biological activities, such as antifungal, antibacterial antiinflammatory, and antioxidant activities, besides antibiotic resistance modulating effects, and anti-HIV, hepatoprotective, and antitumor effect. So, new coumarin derivatives (hydrazones and an amide) were synthesized through multisteps reactions. All the synthesized target compounds were characterized by FT-IR spectroscopy, 1HNMR analysis. The compounds then evaluated for their anti-bacterial activity by means of well-diffusion method against two gram-positive bacteria (Staphylococcus aureus

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Cao, Zhenping, and Jinyao Liu. "Bacteria and bacterial derivatives as drug carriers for cancer therapy." Journal of Controlled Release 326 (October 2020): 396–407. http://dx.doi.org/10.1016/j.jconrel.2020.07.009.

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Hwang, Sumi. "Antibacterial Activity for Synthesized Coumarin Derivatives and a Coumarin Component of Lime Peel (Citrus aurantifolia)." Bioengineering 11, no. 8 (2024): 752. http://dx.doi.org/10.3390/bioengineering11080752.

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In this study, we investigated the antibacterial activity of the coumarin component isolated from lime peel and coumarin derivatives synthesized using various techniques against eight types of food-poisoning bacteria. The minimum inhibitory concentration (MIC) for the 3b [5,7-dihydroxy-4-trifluoromethylcoumarin] derivative was measured as 1.5 mM in Bacillus cereus, Micrococcus luteus, Listeria monocytogenes, and Staphylococcus aureus subsp. aureus; that for the 3c [7-hydroxy-4-trifluoromethylcoumarin] derivative was 1.7 mM in Enterococcus facium; and that for the 3n [dicoumarol] derivative was

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Boukattaya, Fatma, Amal Daoud, Fabien Boeda, et al. "Synthesis and Biological Evaluation of 3-cyano-4H-chromene Derivatives Bearing Carbamate Functionality." Medicinal Chemistry 15, no. 3 (2019): 257–64. http://dx.doi.org/10.2174/1573406414666181009124449.

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Background: 2-Aminochromene derivatives display important pharmacological properties, including mainly antibiotic and anticancer activities. Objective: The study aims to synthesize new chromene derivatives via a new approach using Grignard reagents, for the evaluation of their antibiotic and antifungal properties. Method: A series of novel 3-cyano-4-aminochromene derivatives bearing alkyl substituents at the 4-position was prepared for biological evaluation. Results: These compounds were obtained by the addition of various Grignard reagents into Nethoxycarbonyl- 3-cyanoiminocoumarines in moder

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SarveAhrabi, Yasin, Nakisa Zarrabi Ahrabi, and Ali Souldozi. "Synthesis and Antimicrobial Evaluation of New Series of 1,3,4-Oxadiazole Containing Cinnamic Acid Derivatives." Avicenna Journal of Clinical Microbiology and Infection 8, no. 1 (2021): 11–16. http://dx.doi.org/10.34172/ajcmi.2021.03.

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Background: New drugs must be designed and synthesized for combating resistant pathogens. In this study, antibacterial and antifungal activities of 4 new derivatives of 1,3,4-oxadiazole were assessed against 8 bacterial and 2 fungal pathogens. Methods: To this end, the cinnamic acid derivatives were dissolved in acetonitrile solvent and N-iso-ciano-imino-triphenyl-phosphorane was added to the above-mentioned solution, followed by applying Petroleum ether and Ethyl acetate as solvent and base. Then, antimicrobial susceptibility tests were used to determine inhibition zone diameter, minimum inhi

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M.G., Assy, Abdalha A.A., and Abdel Aziz A.E. "Synthesis and Antimicrobial Evaluation of Some New Benzoxazinone and Quinazolinone Derivatives." JOURNAL OF ADVANCES IN CHEMISTRY 8, no. 1 (2016): 1491–99. http://dx.doi.org/10.24297/jac.v8i1.4030.

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Ring opening reactions of benzoxazinone (2) with nitrogen and oxygen nucleophiles gave the corresponding benzamides (3)&(4) and benzoates (5).Quinazolinone derivatives (6) and (7) were obtained upon treatment of (2) with hydrazine hydrate and/or hydroxylamine hydrochloride.Triazole derivatives (8a – b) were obtained when (2) was subjected to react with semicarbazide and/or thiosemicarbazide respectively. Reaction of (2) with sodium azide gave a mixture of tetrazole derivative (9) and benzoimidazolone derivative (10). The antimicrobial activity of some synthesized compounds was examined aga

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Israpilova, Ashura I., Aina A. Adieva, Albina M. Dzhafarova та Gasan M. Abakarov. "Изучение активности гетероциклических производных теллура в отношении условно-патогенных бактерий". Journal of Medical and Biological Research, № 3 (20 вересня 2024): 301–10. http://dx.doi.org/10.37482/2687-1491-z200.

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Antimicrobial resistance is a serious challenge for medicine and society as a whole. Among the bacteria that pose the greatest threat to human health due to their growing antibiotic resistance are Escherichia coli, Staphylococcus aureus and Salmonella spp. The main reasons behind this problem are the misuse of antibiotics and lack of new antimicrobials, which are difficult to develop due to the complexity of the mechanisms of microbial infections and their limited weak points. Moreover, the process of developing new drugs requires significant time and financial resources. The purpose of this a

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Fadel, F. J., M. M. Kareem, and F. H. Mohammed. "NEW GLYCOGEN DERIVATIVES AS AN ADVANTAGEOUS POLYMERS CARRIER IN BACTERIA THERANOSTICS." Chemical Problems 23, no. 2 (2025): 166–77. https://doi.org/10.32737/2221-8688-2025-2-166-177.

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Pharmaceutical polymers based on glycogen as prodrugs were synthesized to enhance the physical and chemical properties, thereby increasing the solubility of the drugs compared to the original drugs. This improvement leads to better efficacy and bioavailability, enhancing their absorption and distribution within the body. The drug release process in prodrugs contributes to sustained pharmacological effects, extending the duration of therapeutic effects compared to immediate-release formulations. This research involves the preparation of pharmaceutical polymers [FA6-FA10] based on glycogen throu

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Bozinovic, Nina, Irena Novakovic, Sladjana Kostic-Rajacic, Igor Opsenica, and Bogdan Solaja. "Synthesis and antimicrobial activity of azepine and thiepine derivatives." Journal of the Serbian Chemical Society 80, no. 7 (2015): 839–52. http://dx.doi.org/10.2298/jsc150116013b.

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A series of new 5H-pyridobenzazepine and pyridobenzothiepine derivatives was synthesized by Pd-catalyzed formation of C-N and C-S bonds. All synthesized compounds were tested for their in vitro antimicrobial activity. The 5H-pyridobenzazepine derivatives showed better antibacterial and antifungal activity than corresponding 5H-dipyridoazepine analogs. Among the synthesized azepines, derivative 8 displayed potent activity against tested bacteria (MIC = 39-78 ?g/mL), while azepine 12 showed promising antifungal activity (MIC = 156-313 ?g/mL). The synthesized thiepine derivatives exhibited weak a

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Kania, Agnieszka, Waldemar Tejchman, Anna M. Pawlak, et al. "Preliminary Studies of Antimicrobial Activity of New Synthesized Hybrids of 2-Thiohydantoin and 2-Quinolone Derivatives Activated with Blue Light." Molecules 27, no. 3 (2022): 1069. http://dx.doi.org/10.3390/molecules27031069.

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Thiohydantoin and quinolone derivatives have attracted researchers’ attention because of a broad spectrum of their medical applications. The aim of our research was to synthesize and analyze the antimicrobial properties of novel 2-thiohydantoin and 2-quinolone derivatives. For this purpose, two series of hybrid compounds were synthesized. Both series consisted of 2-thiohydantoin core and 2-quinolone derivative ring, however one of them was enriched with an acetic acid group at N3 atom in 2-thiohydantoin core. Antibacterial properties of these compounds were examined against bacteria: Staphyloc

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FAN, XUETONG, KAREN WAGNER, KIMBERLY J. B. SOKORAI, and HELEN NGO. "Inactivation of Gram-Positive Bacteria by Novel Phenolic Branched-Chain Fatty Acids." Journal of Food Protection 80, no. 1 (2016): 6–14. http://dx.doi.org/10.4315/0362-028x.jfp-16-080.

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ABSTRACT Novel phenolic branched-chain fatty acids (PBC-FAs) were evaluated for their antimicrobial properties against both gram-positive (Listeria innocua, Bacillus subtilis, Enterococcus faecium) and gram-negative (Escherichia coli, Salmonella Typhimurium, and Pseudomonas tolaasii) bacteria. In addition, PBC-FA derivatives, such as PBC-FA methyl ester mixture, methyl-branched fatty acid mixtures, and trimethylsilyl–PBC-FA methyl esters, were synthesized to study the structure activity relationship. Results showed that PBC-FAs were a potent antimicrobial against gram-positive bacteria with MI

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Batubara, Nikmah Ridha, Dwi Suryanto, Erman Munir, and Rahmiati Rahmiati. "Screening and Characterization of Chitinolytic Bacteria from Shrimp Waste." JURNAL PEMBELAJARAN DAN BIOLOGI NUKLEUS 8, no. 3 (2022): 744–53. http://dx.doi.org/10.36987/jpbn.v8i3.3251.

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Shrimp waste is a perishable material. The degradation process is carried out by decaying microbes by producing degrading enzymes. The presence of chitin content in shrimp waste causes the emergence of chitinase enzyme-producing bacteria. Chitin is a linear homopolymer composed of N-acetyl-D-glucosamine monomers with -(1,4) glycosidic bonds. Chitin has unique properties, namely; biodegradable, biocompatible and non-toxic. This causes chitin and its derivatives to be widely used in various industrial and biomedical applications so that chitin and its derivatives have great economic value. There

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Kang, Sangrim, Kyoung Sunwoo, Yuna Jung, et al. "Membrane-Targeting Triphenylphosphonium Functionalized Ciprofloxacin for Methicillin-Resistant Staphylococcus aureus (MRSA)." Antibiotics 9, no. 11 (2020): 758. http://dx.doi.org/10.3390/antibiotics9110758.

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Multidrug-resistant (MDR) bacteria have become a severe problem for public health. Developing new antibiotics for MDR bacteria is difficult, from inception to the clinically approved stage. Here, we have used a new approach, modification of an antibiotic, ciprofloxacin (CFX), with triphenylphosphonium (TPP, PPh3) moiety via ester- (CFX-ester-PPh3) and amide-coupling (CFX-amide-PPh3) to target bacterial membranes. In this study, we have evaluated the antibacterial activities of CFX and its derivatives against 16 species of bacteria, including MDR bacteria, using minimum inhibitory concentration

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Al-Rasheed, Hessa H., Monirah Al Alshaikh, Jamal M. Khaled, Naiyf S. Alharbi, and Ayman El-Faham. "Ultrasonic Irradiation: Synthesis, Characterization, and Preliminary Antimicrobial Activity of Novel Series of 4,6-Disubstituted-1,3,5-triazine Containing Hydrazone Derivatives." Journal of Chemistry 2016 (2016): 1–9. http://dx.doi.org/10.1155/2016/3464758.

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Novel series of 4,6-disubstituted-1,3,5-triazines containing hydrazone derivatives were synthesized employing ultrasonic irradiation and conventional heating. The ultrasonication gave the target products in higher yields and purity in shorter reaction time compared with the conventional method. IR, NMR (H 1 and C 13), elemental analysis, and LC-MS confirmed the structures of the new products. The antimicrobial and antifungal activities were evaluated for all the prepared compounds against some selected Gram-positive and Gram-negative bacterial strains. The results showed that only two compound

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