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Journal articles on the topic 'Dictyostelium discoideum. Developmental biology'

Author: Grafiati

Published: 4 June 2021

Last updated: 11 February 2022

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1

Strmecki, Lana, David M. Greene, and Catherine J. Pears. "Developmental decisions in Dictyostelium discoideum." Developmental Biology 284, no. 1 (2005): 25–36. http://dx.doi.org/10.1016/j.ydbio.2005.05.011.

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2

Schaap, P. "Evolutionary crossroads in developmental biology: Dictyostelium discoideum." Development 138, no. 3 (2011): 387–96. http://dx.doi.org/10.1242/dev.048934.

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3

Katoh, Mariko, Guokai Chen, Emily Roberge, Gad Shaulsky, and Adam Kuspa. "Developmental Commitment in Dictyostelium discoideum." Eukaryotic Cell 6, no. 11 (2007): 2038–45. http://dx.doi.org/10.1128/ec.00223-07.

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ABSTRACT Upon starvation, Dictyostelium discoideum cells halt cell proliferation, aggregate into multicellular organisms, form migrating slugs, and undergo morphogenesis into fruiting bodies while differentiating into dormant spores and dead stalk cells. At almost any developmental stage cells can be forced to dedifferentiate when they are dispersed and diluted into nutrient broth. However, migrating slugs can traverse lawns of bacteria for days without dedifferentiating, ignoring abundant nutrients and continuing development. We now show that developing Dictyostelium cells revert to the growt

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4

Kawabe, Yoshinori, Qingyou Du, Christina Schilde, and Pauline Schaap. "Evolution of multicellularity in Dictyostelia." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 359–69. http://dx.doi.org/10.1387/ijdb.190108ps.

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The well-orchestrated multicellular life cycle of Dictyostelium discoideum has fascinated biologists for over a century. Self-organisation of its amoebas into aggregates, migrating slugs and fruiting structures by pulsatile cAMP signalling and their ability to follow separate differentiation pathways in well-regulated proportions continue to be topics under investigation. A striking aspect of D. discoideum development is the recurrent use of cAMP as chemoattractant, differentiation inducing signal and second messenger for other signals that control the developmental programme. D. discoideum is

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Escalante, Ricardo, and Elena Cardenal-Muñoz. "The Dictyostelium discoideum model system." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 317–20. http://dx.doi.org/10.1387/ijdb.190275re.

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When we set out to organize this Special Issue, we faced the difficult task of gathering together a large variety of topics with the unique commonality of having been studied in a single model organism, Dictyostelium discoideum. This apparent setback turned into a wonderful opportunity to learn about an organism as a whole, which provides a more complete understanding of life processes, their natural meaning and their changes during evolution. From studies dedicated almost exclusively to cell motility, differentiation and patterning, the versatility of D. discoideum has allowed in recent years

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Pearce, Xavier G., Sarah J. Annesley, and Paul R. Fisher. "The Dictyostelium model for mitochondrial biology and disease." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 497–508. http://dx.doi.org/10.1387/ijdb.190233pf.

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The unicellular slime mould Dictyostelium discoideum is a valuable eukaryotic model organism in the study of mitochondrial biology and disease. As a member of the Amoebozoa, a sister clade to the animals and fungi, Dictyostelium mitochondrial biology shares commonalities with these organisms, but also exhibits some features of plants. As such it has made significant contributions to the study of eukaryotic mitochondrial biology. This review provides an overview of the advances in mitochondrial biology made by the study of Dictyostelium and examines several examples where Dictyostelium has and

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7

Medina, James M., P. M. Shreenidhi, Tyler J. Larsen, David C. Queller, and Joan E. Strassmann. "Cooperation and conflict in the social amoeba Dictyostelium discoideum." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 371–82. http://dx.doi.org/10.1387/ijdb.190158jm.

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The social amoeba Dictyostelium discoideum has provided considerable insight into the evolution of cooperation and conflict. Under starvation, D. discoideum amoebas cooperate to form a fruiting body comprised of hardy spores atop a stalk. The stalk development is altruistic because stalk cells die to aid spore dispersal. The high relatedness of cells in fruiting bodies in nature implies that this altruism often benefits relatives. However, since the fruiting body forms through aggregation there is potential for non-relatives to join the aggregate and create conflict over spore and stalk fates.

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8

Ramagopal, S. "The Dictyostelium ribosome: biochemistry, molecular biology, and developmental regulation." Biochemistry and Cell Biology 70, no. 9 (1992): 738–50. http://dx.doi.org/10.1139/o92-113.

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This is the first comprehensive review of ribosomes in the cellular slime mold Dictyostelium discoideum. The physicochemical, biochemical, cellular, molecular, and developmental properties are reviewed. Several features demonstrate that a unique class of ribosomes exists in this organism, and a study of these ribosomes will be important to decipher special features of translational regulation, and evolution of the organelle in the eukaryotic kingdom.Key words: cellular slime molds, development, ribosome heterogeneity, protein synthesis, evolution.

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9

Kawli, Trupti, B. R. Venkatesh, Vidyanand Nanjundiah, P. Kevin Kennady, and Gopal Pande. "Correlates of developmental cell death in Dictyostelium discoideum." Differentiation 70, no. 6 (2002): 272–81. http://dx.doi.org/10.1046/j.1432-0436.2002.700605.x.

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10

Knecht, David A., Kate M. Cooper, and Jonathan E. Moore. "Teaching a biology laboratory course using Dictyostelium." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 551–61. http://dx.doi.org/10.1387/ijdb.190249dk.

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The Dictyostelium discoideum model system is a powerful tool for undergraduate cell biology teaching laboratories. The cells are biologically safe, grow at room temperature and it is easy to experimentally induce, observe, and perturb a breadth of cellular processes making the system amenable to many teaching lab situations and goals. Here we outline the advantages of Dictyostelium, discuss laboratory courses we teach in three very different educational settings, and provide tips for both the novice and experienced Dictyostelium researcher. With this article and the extensive sets of protocols

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11

Journet, A., A. Chapel, S. Jehan, et al. "Characterization of Dictyostelium discoideum cathepsin D." Journal of Cell Science 112, no. 21 (1999): 3833–43. http://dx.doi.org/10.1242/jcs.112.21.3833.

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Previous studies using magnetic purification of Dictyostelium discoideum endocytic vesicles led us to the identification of some major vesicle proteins. Using the same purification procedure, we have now focused our interest on a 44 kDa soluble vesicle protein. Microsequencing of internal peptides and subsequent cloning of the corresponding cDNA identified this protein as the Dictyostelium homolog of mammalian cathepsins D. The only glycosylation detected on Dictyostelium cathepsin D (CatD) is common antigen 1, a cluster of mannose 6-sulfate residues on N-linked oligosaccharide chains. CatD in

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12

MORIYAMA, RYOICHI, and KAICHIRO YANAGISAWA. "Protein Synthesis Initiated by Cell Fusion in Dictyostelium discoideum. (Dictyostelimu discoideum/cell fusion/protein synthesis)." Development, Growth and Differentiation 30, no. 2 (1988): 169–81. http://dx.doi.org/10.1111/j.1440-169x.1988.00169.x.

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13

Batsios, Petros, Ralph Gräf, Michael P. Koonce, Denis A. Larochelle, and Irene Meyer. "Nuclear envelope organization in Dictyostelium discoideum." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 509–19. http://dx.doi.org/10.1387/ijdb.190184rg.

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The nuclear envelope consists of the outer and the inner nuclear membrane, the nuclear lamina and the nuclear pore complexes, which regulate nuclear import and export. The major constituent of the nuclear lamina of Dictyostelium is the lamin NE81. It can form filaments like B-type lamins and it interacts with Sun1, as well as with the LEM/HeH-family protein Src1. Sun1 and Src1 are nuclear envelope transmembrane proteins involved in the centrosome-nucleus connection and nuclear envelope stability at the nucleolar regions, respectively. In conjunction with a KASH-domain protein, Sun1 usually for

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14

Vines, James H., and Jason S. King. "The endocytic pathways of Dictyostelium discoideum." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 461–71. http://dx.doi.org/10.1387/ijdb.190236jk.

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The formation and processing of vesicles from the cell surface serves many important cellular functions ranging from nutrient acquisition to regulating the turnover of membrane components and signalling. In this article, we summarise the endocytic pathways of the social amoeba Dictyostelium from the clathrin-dependent and independent internalisation of surface components to the engulfment of bacteria or fluid by phagocytosis and macropinocytosis respectively. Due to similarities with the professional phagocytes of the mammalian immune system Dictyostelium has been extensively used to investiga

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15

Bozzaro, Salvatore. "The past, present and future of Dictyostelium as a model system." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 321–31. http://dx.doi.org/10.1387/ijdb.190128sb.

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The social amoeba Dictyostelium discoideum has been a preferred model organism during the last 50 years, particularly for the study of cell motility and chemotaxis, phagocytosis and macropinocytosis, intercellular adhesion, pattern formation, caspase-independent cell death and more recently autophagy and social evolution. Being a soil amoeba and professional phagocyte, thus exposed to a variety of potential pathogens, D. discoideum has also proven to be a powerful genetic and cellular model for investigating host-pathogen interactions and microbial infections. The finding that the Dictyosteliu

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16

Ayres, K., W. Neuman, W. G. Rowekamp, and S. Chung. "Developmental regulation of DNase I-hypersensitive sites in Dictyostelium discoideum." Molecular and Cellular Biology 7, no. 5 (1987): 1823–29. http://dx.doi.org/10.1128/mcb.7.5.1823-1829.1987.

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We have studied two regions of Dictyostelium discoideum chromatin and identified several DNase I-hypersensitive sites in these regions. One of these sites is located about 300 to 500 bases upstream of the transcriptional start site of a gene that is expressed at all stages of development. This site is present in both vegetative cells and postaggregation cells. Another hypersensitive site is associated with a gene that is expressed only after the multicellular stage. This site is located about 400 bases upstream of the start site, and it is present only in postaggregation cells. Thus, much like

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17

Traincard, F., E. Ponte, J. Pun, B. Coukell, and M. Veron. "Evidence for the presence of an NF-kappaB signal transduction system in Dictyostelium discoideum." Journal of Cell Science 112, no. 20 (1999): 3529–35. http://dx.doi.org/10.1242/jcs.112.20.3529.

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The Rel/NF-kappaB family of transcription factors and regulators has so far only been described in vertebrates and arthropods, where they mediate responses to many extracellular signals. No counterparts of genes coding for such proteins have been identified in the Caenorhabditis elegans genome and no NF-kappaB activity was found in Saccharomyces cerevisiae. We describe here the presence of an NF-kappaB transduction pathway in the lower eukaryote Dictyostelium discoideum. Using antibodies raised against components of the mammalian NF-kappaB pathway, we demonstrate in Dictyostelium cells extract

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18

Varela, Isabel, Michiel M. Van Lookeren Campagne, Jose F. Alvarez, and Jose M. Mato. "The developmental regulation of phosphatidylinositol kinase in Dictyostelium discoideum." FEBS Letters 211, no. 1 (1987): 64–68. http://dx.doi.org/10.1016/0014-5793(87)81275-9.

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19

Schwandner, Wolfgang, and CornelisJ Weijer. "Identification of G proteins in dictyostelium discoideum." Cell Differentiation and Development 27 (August 1989): 132. http://dx.doi.org/10.1016/0922-3371(89)90408-5.

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20

Kundert, Peter, and Gad Shaulsky. "Cellular allorecognition and its roles in Dictyostelium development and social evolution." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 383–93. http://dx.doi.org/10.1387/ijdb.190239gs.

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The social amoeba Dictyostelium discoideum is a tractable model organism to study cellular allorecognition, which is the ability of a cell to distinguish itself and its genetically similar relatives from more distantly related organisms. Cellular allorecognition is ubiquitous across the tree of life and affects many biological processes. Depending on the biological context, these versatile systems operate both within and between individual organisms, and both promote and constrain functional heterogeneity. Some of the most notable allorecognition systems mediate neural self-avoidance in flies

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21

Nagano, Seido. "Modeling the model organism Dictyostelium discoideum." Development, Growth and Differentiation 42, no. 6 (2000): 541–50. http://dx.doi.org/10.1046/j.1440-169x.2000.00547.x.

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22

Tan, J. L., and J. A. Spudich. "Developmentally regulated protein-tyrosine kinase genes in Dictyostelium discoideum." Molecular and Cellular Biology 10, no. 7 (1990): 3578–83. http://dx.doi.org/10.1128/mcb.10.7.3578-3583.1990.

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Dictyostelium discoideum, an organism that undergoes development and that is amenable to biochemical and molecular genetic approaches, is an attractive model organism with which to study the role of tyrosine phosphorylation in cell-cell communication. We report the presence of protein-tyrosine kinase genes in D. discoideum. Screening of a Dictyostelium cDNA expression library with an anti-phosphotyrosine antibody identifies fusion proteins that exhibit protein-tyrosine kinase activity. Two distinct cDNAs were identified and isolated. Though highly homologous to protein kinases in general, thes

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23

Kumagai, Akiko, and Koji Okamoto. "Prespore-inducing factors in Dictyostelium discoideum." Differentiation 31, no. 2 (1986): 79–84. http://dx.doi.org/10.1111/j.1432-0436.1986.tb00386.x.

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24

Fischer, Sarah, and Ludwig Eichinger. "Dictyostelium discoideum and autophagy – a perfect pair." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 485–95. http://dx.doi.org/10.1387/ijdb.190186le.

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Autophagy is subdivided into chaperone-mediated autophagy, microautophagy and macroautophagy and is a highly conserved intracellular degradative pathway. It is crucial for cellular homeostasis and also serves as a response to different stresses. Here we focus on macroautophagy, which targets damaged organelles and large protein assemblies, as well as pathogenic intracellular microbes for destruction. During this process, cytosolic material becomes enclosed in newly generated double-membrane vesicles, the so-called autophagosomes. Upon maturation, the autophagosome fuses with the lysosome for d

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Lamrabet, Otmane, Tania Jauslin, Wanessa Cristina Lima, Matthias Leippe, and Pierre Cosson. "The multifarious lysozyme arsenal of Dictyostelium discoideum." Developmental & Comparative Immunology 107 (June 2020): 103645. http://dx.doi.org/10.1016/j.dci.2020.103645.

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26

Pelech, Steven, Harry Paddon, Linda Kwong, and Gerald Weeks. "Characterization of Developmentally Regulated cAMP/Ca2+-Independent Protein Kinases from Dictyostelium discoideum. (protein phosphorylation/protein kinases/Dictyostelium discoideum)." Development, Growth and Differentiation 31, no. 4 (1989): 351–61. http://dx.doi.org/10.1111/j.1440-169x.1989.00351.x.

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27

Varnum, Barbara, Kevin B. Edwards, and David R. Soll. "The developmental regulation of single-cell motility in Dictyostelium discoideum." Developmental Biology 113, no. 1 (1986): 218–27. http://dx.doi.org/10.1016/0012-1606(86)90124-7.

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28

Kucukyildirim, Sibel, Megan Behringer, Way Sung, et al. "Low Base-Substitution Mutation Rate but High Rate of Slippage Mutations in the Sequence Repeat-Rich Genome of Dictyostelium discoideum." G3 Genes|Genomes|Genetics 10, no. 9 (2020): 3445–52. http://dx.doi.org/10.1534/g3.120.401578.

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Abstract We describe the rate and spectrum of spontaneous mutations for the social amoeba Dictyostelium discoideum, a key model organism in molecular, cellular, evolutionary and developmental biology. Whole-genome sequencing of 37 mutation accumulation lines of D. discoideum after an average of 1,500 cell divisions yields a base-substitution mutation rate of 2.47 × 10−11 per site per generation, substantially lower than that of most eukaryotic and prokaryotic organisms, and of the same order of magnitude as in the ciliates Paramecium tetraurelia and Tetrahymena thermophila. Known for its high

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29

Finney, Robert, Michael Ellis, Carol Langtimm, Elliot Rosen, Richard Firtel, and David R. Soll. "Gene regulation during dedifferentiation in Dictyostelium discoideum." Developmental Biology 120, no. 2 (1987): 561–76. http://dx.doi.org/10.1016/0012-1606(87)90259-4.

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TASAKA, MASAO, CAROLYN A. KAY, SHARON M. SOMMERVILLE, AROLINE E. GRANT, and ADRIAN S. TSANG. "Regulation of Prestalk-specific Acid Phosphatase in Dictyostelium discoideum. (Dictyostelium discoideum/monoclonal antibody/prestalk/acid phosphatase/differentiation)." Development, Growth and Differentiation 28, no. 5 (1986): 471–82. http://dx.doi.org/10.1111/j.1440-169x.1986.00471.x.

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Wetterauer, Birgit, and Harry K. MacWilliams. "A developmental shift in cell volume regulation in Dictyostelium discoideum." Differentiation 45, no. 1 (1990): 14–20. http://dx.doi.org/10.1111/j.1432-0436.1990.tb00451.x.

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32

Sharkey, D. J., and R. Kornfeld. "Developmental regulation of asparagine-linked oligosaccharide synthesis in Dictyostelium discoideum." Journal of Biological Chemistry 266, no. 28 (1991): 18485–97. http://dx.doi.org/10.1016/s0021-9258(18)55087-0.

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33

Estevez, Antonio M., Oscar H. Martinez-Costa, Valentina Sanchez, and Juan J. Aragon. "Cloning, Sequencing and Developmental Expression of Phosphofructokinase from Dictyostelium discoideum." European Journal of Biochemistry 243, no. 1-2 (1997): 442–51. http://dx.doi.org/10.1111/j.1432-1033.1997.0442a.x.

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34

Yin, Y., P. V. Rogers, and C. L. Rutherford. "Dual regulation of the glycogen phosphorylase 2 gene Dictyostelium discoideum: the effects of DIF-1, cAMP, NH3 and adenosine." Development 120, no. 5 (1994): 1169–78. http://dx.doi.org/10.1242/dev.120.5.1169.

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Cell differentiation in Dictyostelium results in the formation of two cell types, stalk and spore cells. The stalk cells undergo programmed cell death, whereas spore cells retain viability. The current evidence suggests that stalk cell differentiation is induced by Differentiation Inducing Factor (DIF), while spore cell differentiation occurs in response to cAMP. We have discovered the first developmentally regulated Dictyostelium gene, the glycogen phosphorylase gene 2 (gp2) gene, that can be induced by both DIF-1 and cAMP, suggesting the possibility of a new group of developmentally regulate

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35

Hoffmann, Anne, Lieselotte Erber, Heike Betat, Peter F. Stadler, Mario Mörl, and Jörg Fallmann. "Changes of the tRNA Modification Pattern during the Development of Dictyostelium discoideum." Non-Coding RNA 7, no. 2 (2021): 32. http://dx.doi.org/10.3390/ncrna7020032.

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Dictyostelium discoideum is a social amoeba, which on starvation develops from a single-cell state to a multicellular fruiting body. This developmental process is accompanied by massive changes in gene expression, which also affect non-coding RNAs. Here, we investigate how tRNAs as key regulators of the translation process are affected by this transition. To this end, we used LOTTE-seq to sequence the tRNA pool of D. discoideum at different developmental time points and analyzed both tRNA composition and tRNA modification patterns. We developed a workflow for the specific detection of modifica

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Araki, Tsuyoshi, and Tamao Saito. "Small molecules and cell differentiation in Dictyostelium discoideum." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 429–38. http://dx.doi.org/10.1387/ijdb.190192ts.

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Dictyostelium is a microorganism found in soils that are known as the battle fields of chemical warfare. Genome analysis of Dictyostelium revealed that it has great potential for the production of small molecules, including secondary metabolites such as polyketides and terpenes.Polyketides are a large family of secondary metabolites which have a variety of structures. In accordance with their structural variety, polyketides have a plethora of biological activities, including antimicrobial, antifungal, and antitumor activities. Unsurprisingly, they have exceptional medical importance. Polyketid

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Alexander, S., and T. M. Shinnick. "Specific regulation of transcription of the discoidin gene family in Dictyostelium discoideum." Molecular and Cellular Biology 5, no. 5 (1985): 984–90. http://dx.doi.org/10.1128/mcb.5.5.984-990.1985.

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Dictyostelium discoideum strains that carry the dis mutations fail to express the family of developmentally regulated discoidin lectin genes during morphogenesis. We show here that this absence of discoidin lectin expression is due to the failure to transcribe the discoidin genes. Furthermore, the dis mutations appear to affect only discoidin expression and not the expression of other proteins during development, as assessed by a two-dimensional gel analysis of pulse-labeled proteins and by the accumulation of developmentally regulated enzymes. The dis mutations appear to define trans-acting r

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Erber, Lieselotte, Anne Hoffmann, Jörg Fallmann, et al. "Unusual Occurrence of Two Bona-Fide CCA-Adding Enzymes in Dictyostelium discoideum." International Journal of Molecular Sciences 21, no. 15 (2020): 5210. http://dx.doi.org/10.3390/ijms21155210.

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Dictyostelium discoideum, the model organism for the evolutionary supergroup of Amoebozoa, is a social amoeba that, upon starvation, undergoes transition from a unicellular to a multicellular organism. In its genome, we identified two genes encoding for tRNA nucleotidyltransferases. Such pairs of tRNA nucleotidyltransferases usually represent collaborating partial activities catalyzing CC- and A-addition to the tRNA 3′-end, respectively. In D. discoideum, however, both enzymes exhibit identical activities, representing bona-fide CCA-adding enzymes. Detailed characterization of the correspondin

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Katoh, Mariko, Tomaz Curk, Qikai Xu, Blaz Zupan, Adam Kuspa, and Gad Shaulsky. "Developmentally Regulated DNA Methylation in Dictyostelium discoideum." Eukaryotic Cell 5, no. 1 (2006): 18–25. http://dx.doi.org/10.1128/ec.5.1.18-25.2006.

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ABSTRACT Methylation of cytosine residues in DNA plays a critical role in the silencing of gene expression, organization of chromatin structure, and cellular differentiation of eukaryotes. Previous studies failed to detect 5-methylcytosine in Dictyostelium genomic DNA, but the recent sequencing of the Dictyostelium genome revealed a candidate DNA methyltransferase gene (dnmA). The genome sequence also uncovered an unusual distribution of potential methylation sites, CpG islands, throughout the genome. DnmA belongs to the Dnmt2 subfamily and contains all the catalytic motifs necessary for cytos

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Huber, Robert J., William D. Kim, and Sabateeshan Mathavarajah. "Inhibiting Neddylation with MLN4924 Suppresses Growth and Delays Multicellular Development in Dictyostelium discoideum." Biomolecules 11, no. 3 (2021): 482. http://dx.doi.org/10.3390/biom11030482.

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Neddylation is a post-translational modification that is essential for a variety of cellular processes and is linked to many human diseases including cancer, neurodegeneration, and autoimmune disorders. Neddylation involves the conjugation of the ubiquitin-like modifier neural precursor cell expressed developmentally downregulated protein 8 (NEDD8) to target proteins, and has been studied extensively in various eukaryotes including fungi, plants, and metazoans. Here, we examine the biological processes influenced by neddylation in the social amoeba, Dictyostelium discoideum, using a well-estab

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Tao, Y. P., T. P. Misko, A. C. Howlett, and C. Klein. "Nitric oxide, an endogenous regulator of Dictyostelium discoideum differentiation." Development 124, no. 18 (1997): 3587–95. http://dx.doi.org/10.1242/dev.124.18.3587.

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We have previously demonstrated that nitric oxide (NO)-generating compounds inhibit D. discoideum differentiation by preventing the initiation of cAMP pulses (Tao, Y., Howlett, A. and Klein, C. (1996) Cell. Signal. 8, 37–43). In the present study, we demonstrate that cells produce NO at a relatively constant rate during the initial phase of their developmental cycle. The addition of oxyhemoglobin, an NO scavenger, stimulates cell aggregation, suggesting that NO has a negative effect on the development of aggregation competence. Starvation of cells in the presence of glucose, which has been sho

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Corney, A. J., A. J. Richards, T. Phillpots, and B. D. Hames. "Developmental regulation of cell-type-enriched mRNAs in Dictyostelium discoideum." Molecular Microbiology 4, no. 4 (1990): 613–23. http://dx.doi.org/10.1111/j.1365-2958.1990.tb00630.x.

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43

MAEDA, MINEKO. "Cell-type Conversion at Low Temperature in Dictyostelium discoideum. (Dictyostelium discoideum/low temperature/proportion regulation/antispore-Ig/ultrastructure)." Development, Growth and Differentiation 27, no. 5 (1985): 583–90. http://dx.doi.org/10.1111/j.1440-169x.1985.00583.x.

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Van Driessche, Nancy, Chad Shaw, Mariko Katoh, et al. "A transcriptional profile of multicellular development inDictyostelium discoideum." Development 129, no. 7 (2002): 1543–52. http://dx.doi.org/10.1242/dev.129.7.1543.

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A distinct feature of development in the simple eukaryote Dictyostelium discoideum is an aggregative transition from a unicellular to a multicellular phase. Using genome-wide transcriptional analysis we show that this transition is accompanied by a dramatic change in the expression of more than 25% of the genes in the genome. We also show that the transcription patterns of these genes are not sensitive to the strain or the nutritional history, indicating that Dictyostelium development is a robust physiological process that is accompanied by stereotypical transcriptional events. Analysis of the

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Kubohara, Yuzuru, and Haruhisa Kikuchi. "Dictyostelium: An Important Source of Structural and Functional Diversity in Drug Discovery." Cells 8, no. 1 (2018): 6. http://dx.doi.org/10.3390/cells8010006.

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The cellular slime mold Dictyostelium discoideum is an excellent model organism for the study of cell and developmental biology because of its simple life cycle and ease of use. Recent findings suggest that Dictyostelium and possibly other genera of cellular slime molds, are potential sources of novel lead compounds for pharmacological and medical research. In this review, we present supporting evidence that cellular slime molds are an untapped source of lead compounds by examining the discovery and functions of polyketide differentiation-inducing factor-1, a compound that was originally isola

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de Hostos, Eugenio L., Gretchen McCaffrey, Richard Sucgang, Daniel W. Pierce, and Ronald D. Vale. "A Developmentally Regulated Kinesin-related Motor Protein fromDictyostelium discoideum." Molecular Biology of the Cell 9, no. 8 (1998): 2093–106. http://dx.doi.org/10.1091/mbc.9.8.2093.

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The cellular slime mold Dictyostelium discoideum is an attractive system for studying the roles of microtubule-based motility in cell development and differentiation. In this work, we report the first molecular characterization of kinesin-related proteins (KRPs) in Dictyostelium. A PCR-based strategy was used to isolate DNA fragments encoding six KRPs, several of which are induced during the developmental program that is initiated by starvation. The complete sequence of one such developmentally regulated KRP (designated K7) was determined and found to be a novel member of the kinesin superfami

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Consalvo, Kristen M., Ramesh Rijal, Yu Tang, Sara A. Kirolos, Morgan R. Smith, and Richard H. Gomer. "Extracellular signaling in Dictyostelium." International Journal of Developmental Biology 63, no. 8-9-10 (2019): 395–405. http://dx.doi.org/10.1387/ijdb.190259rg.

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In the last few decades, we have learned a considerable amount about how eukaryotic cells communicate with each other, and what it is the cells are telling each other. The simplicity of Dictyostelium discoideum, and the wide variety of available tools to study this organism, makes it the equivalent of a hydrogen atom for cell and developmental biology. Studies using Dictyostelium have pioneered a good deal of our understanding of eukaryotic cell communication. In this review, we will present a brief overview of how Dictyostelium cells use extracellular signals to attract each other, repel each

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Walk, Alexander, Jennifer Callahan, Pat Srisawangvong, et al. "Lipopolysaccharide enhances bactericidal activity in Dictyostelium discoideum cells." Developmental & Comparative Immunology 35, no. 8 (2011): 850–56. http://dx.doi.org/10.1016/j.dci.2011.03.018.

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Knecht, David A., Eric D. Green, William F. Loomis, and Randall L. Dimond. "Developmental changes in the modification of lysosomal enzymes in Dictyostelium discoideum." Developmental Biology 107, no. 2 (1985): 490–502. http://dx.doi.org/10.1016/0012-1606(85)90330-6.

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De Wit, RenéJ W., and Tobias F. Rinke De Wit. "Developmental regulation of the folic acid chemosensory system in Dictyostelium discoideum." Developmental Biology 118, no. 2 (1986): 385–91. http://dx.doi.org/10.1016/0012-1606(86)90008-4.

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