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Journal articles on the topic 'Digitalis purpurae'

Author: Grafiati

Published: 7 June 2025

Last updated: 2 August 2025

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1

Vaqqosova, Sh, M. Ismoilova, and Z.Q Axmedova. "YURAK GLIKOZIDLARINI O'ZIDA SAQLOVCHI O'SIMLIKLARNI BIOLOGIK FAOL MODDALARINI O'RGANISH." ACUMEN: INTERNATIONAL JOURNAL OF MULTIDISCIPLINARY RESEARCH 2, no. 2 (2025): 292–95. https://doi.org/10.5281/zenodo.14919987.

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2

Warren, Beverlee. "Digitalis purpurea." American Journal of Cardiology 95, no. 4 (2005): 544. http://dx.doi.org/10.1016/j.amjcard.2004.09.063.

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3

Eagle, Kim, and J. Lawrence Naiman. "Digitalis purpurea (Foxglove)." New England Journal of Medicine 331, no. 23 (1994): 1563. http://dx.doi.org/10.1056/nejm199412083312306.

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4

Iten, Manuela, Michael Studhalter, Markus Lampert, Philipp Walter, and Reto Paganoni. "Digitalis purpurea: ein Suizidversuch." Praxis 107, no. 1 (2018): 35–38. http://dx.doi.org/10.1024/1661-8157/a002862.

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Zusammenfassung. Wir präsentieren den Fall einer 23-jährigen Patientin, die in suizidaler Absicht Blätter des Roten Fingerhutes sammelte und einnahm. Trotz Einnahme einer relevanten Dosis hatte sie jedoch nur geringe Symptome. Intoxikationen mit Herzglykosiden sind selten, können aber relevante Herzrhythmusstörungen verursachen. Die einzige wirksame Behandlung stellt die frühzeitige und ggf. prophylaktische Gabe von digitalisspezifischen Fab-Antikörpern dar.

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5

Rietbrock, N., and B. Woodcock. "Digitalis purpurea 1785–1985." DMW - Deutsche Medizinische Wochenschrift 110, no. 26 (2009): 1052–54. http://dx.doi.org/10.1055/s-0029-1236298.

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6

Tjosvold, S. A., and S. T. Koike. "First Occurrence of Downy Mildew on Digitalis purpurea (Common Foxglove), Caused by Peronospora digitalidis, in California and the United States." Plant Disease 86, no. 10 (2002): 1176. http://dx.doi.org/10.1094/pdis.2002.86.10.1176c.

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In California, Digitalis purpurea (common foxglove) and D. grandiflora (yellow foxglove) are grown as cutflower, potted, and landscape plant commodities. In the spring of 2002, after seasonably wet and cool weather, severe downy mildew was observed on potted common foxglove plants in commercial nurseries in coastal California (Santa Cruz County). Initial symptoms on leaves consisted of light green, rectangular areas that were vein-delimited and measured 2 to 5 × 8 to 12 mm. Such spots later became chlorotic. As disease progressed, chlorotic spots coalesced and turned necrotic. The purple-gray

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7

Silalahi, Marina. "Pemanfaatan, Toksisitas dan Glikosida Jantung dari Digitalis purpurea L." Pro-Life 10, no. 1 (2023): 696–706. https://doi.org/10.33541/pro-life.v10i1.4572.

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Digitalis purpurea (Schrophulariaceae) is used by the local Indonesian community as an ornamental plant, even though this plant has high toxicity and has the potential to treat heart problems. This study aims to explain the botany, bioactivity and toxicity of D. purpurea based on literature studies. Literature was obtained online, especially Google scholar using the keywords Digitalis purpurea, bioactivity D. purpurea, and glycoside heart. In Europe, D. purpurea is very popular to treat congestive heart failure and has been used since 200 years ago, but it is very toxic to humans. Digitalis po

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8

Pogrebnyak, N. Ya, L. N. Shisha, S. V. Storozhenko, L. I. Yuzefovich, B. Dittrich, and Yu Yu Gleba. "Genetic transformation of Digitalis purpurea by Agrobacterium tumefaciens." Biopolymers and Cell 13, no. 1 (1997): 60–62. http://dx.doi.org/10.7124/bc.000468.

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9

Sharma, Anup, and Bulbul Purkait. "Quality Assessment of Serially Ultradiluted and Agitated Drug Digitalis purpurea by Emission Spectroscopy and Clinical Analysis of Its Effect on the Heart Rate of Indian Bufo melanostictus." Journal of Pharmaceutics 2013 (December 27, 2013): 1–6. http://dx.doi.org/10.1155/2013/571464.

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The investigation of ultradiluted (homeopathic) drugs is extremely interesting and challenging, and from that point of view this study shows novelty. A study of in vivo changes in heart rate of the Indian Bufo melanostictus caused by commercially available serially ultra-diluted and agitated extract of Digitalis purpurea has been tried in order to understand their pharmacological role. RR interval (of ECG) was compared after intraperitoneal administration of serially diluted and agitated Digitalis purpurea extract, diluent rectified spirit, and Digoxin in anesthetized animals. The study reveal

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10

Janert, L. "Conium maculatum und Digitalis purpurea." Allgemeine Homöopathische Zeitung 204, no. 02 (2007): 59–66. http://dx.doi.org/10.1055/s-2006-934925.

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11

Husemann, F. "Digitalis purpurea und die Herzbewegung." Der Merkurstab 39, Sonderheft-1 (1986): 8–21. http://dx.doi.org/10.14271/dms-14962-de.

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12

Ritz, E., and W. Schoner. "Von Digitalis purpurea zur Krötenhaut." DMW - Deutsche Medizinische Wochenschrift 133, no. 51/52 (2008): 2690–94. http://dx.doi.org/10.1055/s-0028-1105877.

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13

Sepasgosarian, Jasmin, Peter Meiß, and E. Reinhard. "Co-Cultivation of Digitalis purpurea and Digitalis lanata Cell Cultures." Planta Medica 52, no. 06 (1986): 512–13. http://dx.doi.org/10.1055/s-2007-969286.

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14

Elmqvist, Ada, Johan Karnell, and Håkan Rydin. "Digitalis Purpurea v. Digitalis Lanata: An Experimental and Clinical Investigation." Acta Pharmacologica et Toxicologica 6, no. 4 (2009): 319–32. http://dx.doi.org/10.1111/j.1600-0773.1950.tb03478.x.

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15

Atole, S. S. Randhawan B. B*. Mudgal A. S. Salunke S. S. "A Review on Systematic Study of Digitalies." International Journal of Pharmaceutical Sciences 2, no. 11 (2024): 1777–81. https://doi.org/10.5281/zenodo.14250300.

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Digitalis purpurea L. is an important medicinal plant belonging to the family Scrophulariaceae and is an important source of secondary metabolites. The exclusively important digitalis purpurea L. ( Foxglove) Belongs to the family Scrophulariaceae and is distributed throughout the European continent. The phytochemical screening showed the presence of cardiac glucosides, flavonoids, anthraquinones, and also tripenes. But the most important of the phytoconstituents contributed by D.purpurea is the striking presence of numerous cardioactive glycosi6that that have proven to be the most important dr

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16

Jin, Qinglong, Hong-Guang Jin, Ji-Eun Shin, Jong-Ki Hong, and Eun-Rhan Woo. "Phenylethanoid Glycosides from Digitalis purpurea L." Bulletin of the Korean Chemical Society 32, no. 5 (2011): 1721–24. http://dx.doi.org/10.5012/bkcs.2011.32.5.1721.

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17

Woodcock, Barry G., and Eric Ingram. "Digitalis purpurea and the Meddygon Myddfai." Trends in Pharmacological Sciences 7 (January 1986): 178. http://dx.doi.org/10.1016/0165-6147(86)90307-x.

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18

Deluca, Mónica E., Alicia M. Seldes, and Eduardo G. Gros. "Biosynthesis of digitoxin in Digitalis purpurea." Phytochemistry 28, no. 1 (1989): 109–11. http://dx.doi.org/10.1016/0031-9422(89)85019-8.

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19

Silva, J., E. T. Gomes, R. Serrano, and and O. Silva. "Identification by Microscopy of a Natural Hybrid between Portuguese Digitalis Species." Microscopy and Microanalysis 18, S5 (2012): 43–44. http://dx.doi.org/10.1017/s1431927612012871.

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Digitalis purpurea L. and Digitalis thapsi L. (Iberian endemism) are two well known Portuguese species that contain cardiac glycosides. Last year we found some specimens in the Northeast region of Portugal that appeared to us to be natural hybrids between D. purpurea and D. thapsi. In consequence, morphological, genetic and chemical experimental work was performed, involving a minimum of 30 samples of each plant species collected in this geographic area. Preliminary results of this work have been published.

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20

Janicka, Dorota, Krzysztof Wraga, and Agnieszka Zawadzińska. "Evaluation of decorative value of selected taxa of the genus Digitalis." Acta Agrobotanica 64, no. 4 (2012): 75–84. http://dx.doi.org/10.5586/aa.2011.048.

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In the years 2008-2010, evaluation of decorative value of <i>Digitalis grandiflora</i> Mill., <i>D. laevigata</i> Waldst. et Kit., <i>D. lanata</i> Ehrh., <i>D. lutea</i> L., <i>D.</i> × <i>mertonensis</i> 'Summer King', <i>D. purpurea</i> L. 'Apricot', 'Foxy','Pam's Choice' and <i>D. thapsi</i> L. 'Spanish Peaks<sup>®</sup>' was carried out. Plants were evaluated at the vegetative and generative stage. Foxglove seedlings were characterized by high quality, proportional rosettes, healthy

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21

Negi, J. S., V. K. Bisht, A. K. Bhandari, and R. C. Sundriyal. "Determination of mineral contents of Digitalis purpurea L. and Digitalis lanata Ehrh." Journal of soil science and plant nutrition, ahead (2012): 0. http://dx.doi.org/10.4067/s0718-95162012005000008.

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22

Jensen, Kjell Briseid. "Chemical and Biological Assay of Digitalis Purpurea." Acta Pharmacologica et Toxicologica 13, no. 4 (2009): 381–404. http://dx.doi.org/10.1111/j.1600-0773.1957.tb00275.x.

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23

Woodcock, Barry G., and Norbert Rietbrock. "The forgotten cardiac glycoside of Digitalis purpurea." Trends in Pharmacological Sciences 6 (January 1985): 273–75. http://dx.doi.org/10.1016/0165-6147(85)90125-7.

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24

Bonfill, Mercedes, Javier Palazón, Rosa M. Cusidó, M. Teresa Piñol, and Carmen Morales. "Effect of auxin and phenobarbital on the ultrastructure and digitoxin content in Digitalis purpurea tissue culture." Canadian Journal of Botany 74, no. 3 (1996): 378–82. http://dx.doi.org/10.1139/b96-047.

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Callus derived from Digitalis purpurea hypocotils were grown during a 6-week period on solid Murashige–Skoog medium supplemented with 1 mg/L 6-benzylaminopurine, 0.01 mg/L gibberellic acid and 0.1 mg/L indole-3-acetic acid or α-naphthaleneacetic acid, with or without phenobarbital (40 mg/L). The presence of phenobarbital in the culture medium caused a reduction of the vacuole/cytoplasm ratio. At the same time, the chloroplastic volume fraction decreased in callus tissue cells grown in media supplemented with phenobarbital, while the mitochondrial volume ratio increased. Digitoxin content was e

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25

Chon, Young Shin, Kyeong Jin Jeong, and Jae Gill Yun. "Improvement of Commercial Value of Potted Digitalis(Digitalis purpurea) by Plant Growth Retardants." Journal of Korea Society for Plants People and Environment 17, no. 4 (2014): 291–95. http://dx.doi.org/10.11628/ksppe.2014.17.4.291.

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26

Ciocarlan, Nina. "A brief review on medicinal Digitalis L. species grown in the ʺAlexandru Ciubotaruʺ National Botanical Garden (Institute)". Journal of Botany XV, № 1(26) (2024): 99–100. http://dx.doi.org/10.52240/1857-2367.2023.1(26).07.

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The paper presents a brief review on the medicinal importance and possibilities of capitalization of Digitalis L. taxa (D. ciliata Trautv., D. ferruginea L., D. grandifl ora Mill., D. laevigata Waldst. ex Kit., D. lanata Ehrh., D. lutea L., D. lutea subsp. australis (Ten.) Arcang., D. purpurea L., D. purpurea var. albifl ora Lej.) intro duced in the Natio nal Botanical Garden (Institute) “Al. Ciubotaru”. The main morphological characteristics of the plants are described, the bioactive components and medicinal properties are summarized. The notable presence of cardioactive glycosides in the spe

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27

Gvazava, L. N., and V. S. Kukoladze. "Phytoecdysteroids from Digitalis ciliata and D. purpurea leaves." Chemistry of Natural Compounds 46, no. 1 (2010): 146–47. http://dx.doi.org/10.1007/s10600-010-9551-3.

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28

Sletvold, Nina, and John M. Grindeland. "Fluctuating selection on reproductive timing in Digitalis purpurea." Oikos 116, no. 3 (2006): 473–81. http://dx.doi.org/10.1111/j.2006.0030-1299.15263.x.

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29

Jin, Qinglong, Hong-Guang Jin, Ji Eun Shin, Jongki Hong, and Eun-Rhan Woo. "ChemInform Abstract: Phenylethanoid Glycosides from Digitalis purpurea L." ChemInform 42, no. 42 (2011): no. http://dx.doi.org/10.1002/chin.201142204.

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30

Makarov, P. N. "Microclonal reproduction of Digitalis purpurea L. and adaptation of regenerants in hydroponics." Izvestiâ Timirâzevskoj selʹskohozâjstvennoj akademii, no. 4 (2024): 53–69. http://dx.doi.org/10.26897/0021-342x-2024-4-53-69.

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The paper presents the results of the development of the microclonal propagation technology of Digitalis purpurea L. with plant adaptation in hydroponic Ebb and Flow Systems. It has been found that MS and WPM growth media with a full and reduced content of mineral salts supplemented with 6-BAP cytokinines, 2-iP and auxins of indoleacetic acid, isobutyric acid in various concentrations can be highly efficient for in vitro cultivation of the plants. Intensive shoot proliferation and rhizogenesis of plants in vitro culture is observed on MS and WPM growth media with a twofold reduced content of m

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31

Marchesi, E. "Scrophulariaceae en el Uruguay." Agrociencia 1, no. 1 (1997): 60–79. http://dx.doi.org/10.31285/agro.01.1011.

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Las Scrophulariaceae en el Uruguay están representadas por 22 géneros y 44 especies. 11 géneros y 32 especies indígenas; 8 géneros y 12 especies adventicias. Se citan por primera vez para el país: los géneros Melasma y Digitalis; las especies: Scoparia ericacea, Melasma rhinanthoides, Micranthemum tweediei, Stemodia stricta, Mecardonia tenella v. microphylla, Digitalis purpurea.

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32

Abboud, Mervat Najem Fakhri, and Abdul Kareem A. J. Mohammad Saeed. "Effect of Foliar Spraying with Methyl Jasmonate on Growth and Production of some Cardiac Glycosides of Digitalis purpurea L. Under Water Stress." IOP Conference Series: Earth and Environmental Science 1262, no. 4 (2023): 042007. http://dx.doi.org/10.1088/1755-1315/1262/4/042007.

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Abstract The experiment was conducted in one of the greenhouses affiliated to Baquba Nursery Research Station Center / Diyala Agriculture Directorate during autumn season of the year 2021-2022, to study the effect of methyl Jasmonate on the growth and production of some cardiac glycosides of Digitalis purpurea under water stress. A factorial experiment (2 × 3 × 3) was conducted according to the RCBD, with three replicates, and the results of the experiment were as follows: The results of the experiment indicated that there was a significant effect of the treatments for the irrigation periods,

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33

Amiri, Fatemeh, Ali Moghadam, Ahmad Tahmasebi, and Ali Niazi. "Identification of key genes involved in secondary metabolite biosynthesis in Digitalis purpurea." PLOS ONE 18, no. 3 (2023): e0277293. http://dx.doi.org/10.1371/journal.pone.0277293.

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The medicinal plant Digitalis purpurea produces cardiac glycosides that are useful in the pharmaceutical industry. These bioactive compounds are in high demand due to ethnobotany’s application to therapeutic procedures. Recent studies have investigated the role of integrative analysis of multi-omics data in understanding cellular metabolic status through systems metabolic engineering approach, as well as its application to genetically engineering metabolic pathways. In spite of numerous omics experiments, most molecular mechanisms involved in metabolic pathways biosynthesis in D. purpurea rema

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34

Litvinov, S. V., L. G. Lioshyna, O. V. Bulko, K. V. Lystvan, and S. A. Pchelovska. "Changes in the content of carotenoids and flavonoids in medicinal raw material of Digitalis purpurea, Polemonium caeruleum, and Aerva lanata, cultivated in vitro under the chronic action of ionizing radiation." Nuclear Physics and Atomic Energy 22, no. 1 (2021): 85–92. http://dx.doi.org/10.15407/jnpae2021.01.085.

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Chronic low-dose γ-irradiation of Digitalis purpurea and Aerva lanata plants in vitro have led to an increase in the content of carotenoids and flavonoids in the leaves at the beginning of the post-radiation period. In the following, the content of pigments and flavonoids decreased in comparison to the control samples. For Polemonium caeruleum such changes had been not observed. The qualitative composition of the secondary metabolites has not been changed, but the ratio of the individual components of the extract varied within a small range. Ri-transformants of Digitalis purpurea have been sho

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35

Gudžinskas, Zigmantas. "Alien herbaceous plant species new to Lithuania." Botanica Lithuanica 23, no. 1 (2017): 33–42. http://dx.doi.org/10.1515/botlit-2017-0003.

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AbstractThis paper presents information about ten new alien plant species recorded in Lithuania in the period from 1995 to 2014. These species belong to eight families: Cucurbitaceae (Lagenaria siceraria), Juncaceae (Luzula sylvestris), Lamiaceae (Physostegia virginiana, Sideritis montana), Poaceae (Melica altissima, Miscanthus sacchariflorus), Portulacaceae (Claytonia perfoliata), Scrophulariaceae (Digitalis purpurea), Solanaceae (Datura inoxia) and Zygophyllaceae (Tribulus terestris). Three species (Claytonia perfoliata, Sideritis montana and Tribulus terestris) were introduced accidentally,

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36

Rothe, K. "Uptake of phloem-specific cardenolides by Cuscuta sp. growing on Digitalis lanata and Digitalis purpurea." Phytochemistry 51, no. 3 (1999): 357–61. http://dx.doi.org/10.1016/s0031-9422(98)00749-3.

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37

Thomas, D., M. Quick, and R. Morgan. "Suspected foxglove (Digitalis purpurea) poisoning in a dairy cow." Veterinary Record 120, no. 13 (1987): 300–301. http://dx.doi.org/10.1136/vr.120.13.300.

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38

Abdulraheem, Zaynab Hammed, Ali Mohammed Noori, Huda S. Husni, Mohammed Abdul Aziz Lateef, and Marwa Fadhil Alsaffar. "Digitalis purpurea L. Propagated in Vitro with Various Hormones." IOP Conference Series: Earth and Environmental Science 1371, no. 4 (2024): 042050. http://dx.doi.org/10.1088/1755-1315/1371/4/042050.

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Abstract The research was conducted in 2024 at the Department of Horticulture and Landscape Design, College of Agriculture, University of Kirkuk, IRAQ, plant cell and tissue culture laboratory. The seeds of digitalis plants, which were procured from the Spanish firm Semill Asfitto, were utilized in an investigation into the impact of gibberellic acid (GA3) and cytokine (BA) on increased vegetative growth characteristics and moist and dry weight, as well as to ascertain the most effective concentration of these substances. In accordance with a completely randomized design (CRD), ten replication

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39

Pérez-Alonso, Naivy, Borys Chong-Pérez, Alina Capote, et al. "Agrobacterium tumefaciens-mediated genetic transformation of Digitalis purpurea L." Plant Biotechnology Reports 8, no. 5 (2014): 387–97. http://dx.doi.org/10.1007/s11816-014-0329-0.

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40

Jensen, Kjell Briseid. "Paper-Chromatographie Detection of New Glycosides in Digitalis Purpurea." Acta Pharmacologica et Toxicologica 9, no. 3 (2009): 275–90. http://dx.doi.org/10.1111/j.1600-0773.1953.tb02956.x.

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41

Dnyandeep, Jadhav* Dipak Borse Chaitanya Baviskar Arvind K. Hatkar Rajendra M. Kawade. "To prepare suspension of digitalis for congestive heart failures." International Journal in Pharmaceutical Sciences 1, no. 12 (2023): 714–21. https://doi.org/10.5281/zenodo.10426636.

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This study outlines the preparation of a digitalis suspension for congestive heart failure (CHF) management. The method involves extracting digitalis glycosides from Digitalis purpurea leaves, followed by meticulous processing to achieve a stable suspension. The formulation's efficacy in addressing CHF symptoms is assessed, providing insights into its potential therapeutic value. This research contributes to the exploration of alternative formulations for digitalis administration in congestive heart failure patients. Digitalis, commonly derived from the foxglove plant, is a medication used to

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42

Ikeda, Yukari, Youichi Fujii, Ikuko Nakaya, and Mitsuru Yamazaki. "Quantitative Hplc Analysis of Cardiac Glycosides in Digitalis purpurea Leaves." Journal of Natural Products 58, no. 6 (1995): 897–901. http://dx.doi.org/10.1021/np50120a012.

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43

Maier, Marta S., Alicia M. Seldes, and Eduardo G. Gros. "Biosynthesis of the butenolide ring of cardenolides in Digitalis purpurea." Phytochemistry 25, no. 6 (1986): 1327–29. http://dx.doi.org/10.1016/s0031-9422(00)81282-0.

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44

KUDO, MARIKO, ROBERT A. WATT, and ANTHONY C. MOFFAT. "Rapid Identification of Digitalis purpurea Using Near-Infrared Reflectance Spectroscopy." Journal of Pharmacy and Pharmacology 52, no. 10 (2000): 1271–77. http://dx.doi.org/10.1211/0022357001777252.

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45

Jensen, Kjell Briseid. "Paper Chromatography of Cardiac Glycosides and Aglyeones from Digitalis Purpurea." Acta Pharmacologica et Toxicologica 9, no. 2 (2009): 99–108. http://dx.doi.org/10.1111/j.1600-0773.1953.tb02934.x.

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46

Rietbrock, Norbert, and Barry G. Woodcock. "Two hundred years of foxglove therapy Digitalis purpurea 1785–1985." Trends in Pharmacological Sciences 6 (January 1985): 267–69. http://dx.doi.org/10.1016/0165-6147(85)90123-3.

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47

Seitz, Hanns Ulrich, and Dorothea Elisabeth G�rtner. "Enzymes in cardenolide-accumulating shoot cultures of Digitalis purpurea L." Plant Cell, Tissue and Organ Culture 38, no. 2-3 (1994): 337–44. http://dx.doi.org/10.1007/bf00033894.

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48

Chaturvedi, H. C., and Madhu Jain. "Restoration of regeneration potentiality in prolonged culture of Digitalis purpurea." Plant Cell, Tissue and Organ Culture 38, no. 1 (1994): 73–75. http://dx.doi.org/10.1007/bf00034448.

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49

Deluca, Mónica E., Alicia M. Seldes та Eduardo G. Gros. "The 14β-Hydroxylation in the Biosynthesis of Cardenolides in Digitalis purpurea. The Role of 3β-Hydroxy-5β-pregn-8(14)-en-20-one". Zeitschrift für Naturforschung C 42, № 1-2 (1987): 77–78. http://dx.doi.org/10.1515/znc-1987-1-213.

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Abstract Labelled 3β-hydroxy-5β-pregnan-20-one was incorporated by Digitalis purpurea plants into digitoxin while 3β-hydroxy-5β-pregn-8(14)-en-20-one was not. This result excluded the intermediary role of the latter compound as precursor of cardenolides in the mentioned plant.

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50

Lokesh, Mahajan* Mansi Mahajan Nandini Mahale Meenaz Sayyed Ravindra Patil. "Analytical Method (HPLC) for Determination of Digitalis as a Cardiotonic Drug." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1186–97. https://doi.org/10.5281/zenodo.15018744.

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Digitalis, a cardiotonic used for the treatment of heart conditions like atrial fibrillation and heart failure is one of this well-known drugs. My favourite Cinchona80 is mixed with plant Digitalis purpurea. When the pump of Na+/K+-ATPase is inhibited, digoxin and digitoxin both augment myocardial contractility. Given the narrow therapeutic index of digitalis glycosides, their accurate quantification in pharmaceutical formulations and bio-fluids is necessary to determine drug efficacy as well as safety. The accurate and reliable quantitation of digitalis glycosides using High Performance Liqui

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