Academic literature on the topic 'Dihydrophthalazines'

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Journal articles on the topic "Dihydrophthalazines"

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Clark, Catherine, Lois M. Ednie, Gengrong Lin, et al. "Antistaphylococcal Activity of Dihydrophthalazine Antifolates, a Family of Novel Antibacterial Drugs." Antimicrobial Agents and Chemotherapy 53, no. 4 (2009): 1353–61. http://dx.doi.org/10.1128/aac.01619-08.

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ABSTRACT For a panel of 153 Staphylococcus aureus clinical isolates (including 13 vancomycin-intermediate or heterogeneous vancomycin-intermediate and 4 vancomycin-resistant strains), MIC50s and MIC90s of three novel dihydrophthalazine antifolates, BAL0030543, BAL0030544, and BAL0030545, were 0.03 and 0.25 μg/ml, respectively, for methicillin-susceptible strains and 0.03 and ≤0.25 μg/ml, respectively, for methicillin-resistant strains. For a panel of 160 coagulase-negative staphylococci (including 5 vancomycin-intermediate and heterogeneous vancomycin-intermediate strains and 7 linezolid-nonsu
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Caspers, Patrick, Luc Bury, Bérangère Gaucher, et al. "In Vitro and In Vivo Properties of Dihydrophthalazine Antifolates, a Novel Family of Antibacterial Drugs." Antimicrobial Agents and Chemotherapy 53, no. 9 (2009): 3620–27. http://dx.doi.org/10.1128/aac.00377-09.

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ABSTRACT Racemic 2,4-diaminopyrimidine dihydrophthalazine derivatives BAL0030543, BAL0030544, and BAL0030545 exhibited low in vitro MICs toward small, selected panels of Enterococcus faecalis, Enterococcus faecium, Streptococcus pneumoniae, Moraxella catarrhalis, and Mycobacterium avium, though the compounds were less active against Haemophilus influenzae. The constellation of dihydrofolate reductases (DHFRs) present in 20 enterococci and 40 staphylococci was analyzed and correlated with the antibacterial activities of the dihydrophthalazines and trimethoprim. DHFRs encoded by dfrB, dfrA (S1 i
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Lukács, Gyula, and Gyula Simig. "Synthesis of new 1,2-dihydrophthalazines." Journal of Heterocyclic Chemistry 39, no. 5 (2002): 989–96. http://dx.doi.org/10.1002/jhet.5570390520.

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Potikha, Lyudmyla M., Volodymyr S. Brovarets, and Victor V. Zhirnov. "Anticancer evaluation of difunctional substituted 1,2-dihydrophthalazines." Chemical Data Collections 37 (February 2022): 100817. http://dx.doi.org/10.1016/j.cdc.2021.100817.

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Jørgensen, K., K. Frisch, A. Landa, and S. Saaby. "Enantioselective Synthesis of 1,2-Dihydroisoquinolines and 1,2-Dihydrophthalazines." Synfacts 2006, no. 01 (2005): 0024. http://dx.doi.org/10.1055/s-2005-921690.

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Pei, Xue-Feng, Michael A. Sturgess, C. Fernando Valenzuela, and Maria-Luisa Maccecchini. "Allosteric modulators of the ampa receptor: Novel 6-substituted dihydrophthalazines." Bioorganic & Medicinal Chemistry Letters 9, no. 4 (1999): 539–42. http://dx.doi.org/10.1016/s0960-894x(99)00044-x.

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OPARIN, D. A. "ChemInform Abstract: Synthesis of 1-(2,4-Dinitrophenylhydrazono)-2,4-diaryl-1,2- dihydrophthalazines." ChemInform 25, no. 4 (2010): no. http://dx.doi.org/10.1002/chin.199404182.

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Pelletier, Jeffrey C., David P. Hesson, Kenneth A. Jones, and Anna-Maria Costa. "Substituted 1,2-Dihydrophthalazines: Potent, Selective, and Noncompetitive Inhibitors of the AMPA Receptor." Journal of Medicinal Chemistry 39, no. 2 (1996): 343–46. http://dx.doi.org/10.1021/jm950740w.

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Pei, Xue-Feng, Michael A. Sturgess, C. Fernando Valenzuela, and Maria-Luisa Maccecchini. "ChemInform Abstract: Allosteric Modulators of the AMPA Receptor: Novel 6-Substituted Dihydrophthalazines." ChemInform 30, no. 26 (2010): no. http://dx.doi.org/10.1002/chin.199926157.

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Aljaar, Nayyef, Jürgen Conrad, and Uwe Beifuss. "Synthesis of 2-Aryl-1,2-dihydrophthalazines via Reaction of 2-(Bromomethyl)benzaldehydes with Arylhydrazines." Journal of Organic Chemistry 78, no. 3 (2013): 1045–53. http://dx.doi.org/10.1021/jo302491x.

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Book chapters on the topic "Dihydrophthalazines"

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Haider, N., and W. Holzer. "Oxidation of Dihydrophthalazines." In Six-Membered Hetarenes with Two Identical Heteroatoms. Georg Thieme Verlag KG, 2004. http://dx.doi.org/10.1055/sos-sd-016-00417.

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"1-Hydroxy-3-Aryl-3,4-Dihydrophthalazine-4-Acetic Acids." In Chemistry of Heterocyclic Compounds: A Series Of Monographs. John Wiley & Sons, Inc., 2008. http://dx.doi.org/10.1002/9780470186558.ch14.

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Boddapati, S. N. Murthy, Jaganmohana Rao Saketi, A. Emmanuel Kola, and Giri Prasad Gorumutchu. "Preparation of Novel Dihydrophthalazinyl Phenylamide Derivatives and their Anti-Microbial Evaluation." In Recent Developments in Chemistry and Biochemistry Research Vol. 3. B P International, 2024. http://dx.doi.org/10.9734/bpi/rdcbr/v3/308.

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