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Dissertations / Theses on the topic 'Dipeptidy'

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Published: 4 June 2021

Last updated: 1 February 2022

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1

Tran, Tinh Vi. "The hydrolysis rate of fluorescent dipeptides by dipeptidyl peptidase I (DPPI)." Thesis, Georgia Institute of Technology, 1999. http://hdl.handle.net/1853/10132.

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2

Orozco, Erika Vanessa Meñaca. "Síntese e relações estrutura-atividade de dipeptidil-nitrilas inibidoras da cruzaína." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-06052015-141806/.

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A cruzaína é a principal cisteíno protease encontrada no parasito Trypanosoma cruzi, o agente etiológico da Doença de Chagas. A enzima é essencial para o desenvolvimento e sobrevivência do parasito dentro do hospedeiro e possui uma excelente validação pré-clínica como alvo susceptível à ação de fármacos. Várias classes de inibidores peptídicos reversíveis e irreversíveis, baseados no estado de transição, inibem efetivamente a cruzaína. No entanto, a maioria destes inibidores ainda não apresenta perfis farmacodinâmicos/farmacocinéticos adequados e/ou estão relacionados com potenciais efeitos fo

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3

Cardoso, Kiara Carolina 1979. "Transcriptoma da glândula venenífera da serpente Bothrops alternatus (urutu) e caracterização molecular e bioquímica parcial da dipeptidilpeptidase IV." [s.n.], 2011. http://repositorio.unicamp.br/jspui/handle/REPOSIP/312156.

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Orientador: Stephen Hyslop<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Ciências Médicas<br>Made available in DSpace on 2018-08-19T08:32:10Z (GMT). No. of bitstreams: 1 Cardoso_KiaraCarolina_D.pdf: 27750375 bytes, checksum: a1ca027909bfd58421b986e75bfcd515 (MD5) Previous issue date: 2011<br>Resumo: O estudo do transcriptoma de bibliotecas de cDNA da glândula venenífera de serpentes, realizado a partir da análise de ESTs (expressed sequence tags), tem se mostrado útil na identificação de genes expressos neste tecido, inclusive no gênero Bothrops, responsável pela maio

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4

Wienand, Wolfgang. "Ein künstlicher Rezeptor für das Dipeptid D-Alanin-D-Alanin Konzeption, Synthese und physikalisch-organische Charakterisierung /." [S.l. : s.n.], 2002. http://deposit.ddb.de/cgi-bin/dokserv?idn=965869032.

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5

Junior, Daniel Francisco de Arruda. "A inibição da enzima dipeptidil peptidase IV melhora a função cardiorrenal de ratos com insuficiência cardíaca." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-09062015-163759/.

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Dados recentes do nosso laboratório sugerem que a enzima dipeptidil peptidase IV (DPPIV), uma serino-protease que pode ser encontrada ancorada na membrana celular de diversos tipos celulares ou na forma solúvel no plasma, possui um papel importante na fisiopatologia da insuficiência cardíaca (IC). Mais especificamente, demonstramos que a atividade da DPPIV circulante está associada com piores desfechos cardiovasculares em modelo experimental e pacientes com IC. Ademais, observamos que a inibição crônica da DPPIV atenua o desenvolvimento e/ou a progressão da IC em ratos submetidos à injúria do

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6

Gangadharaiah, Dayananda Sagar. "PATTERNS OF DIPEPTIDE USAGE FOR GENE PREDICTION." Wright State University / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=wright1279304144.

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7

Knorr, Karsten. "Amidopyrazolylguanidine - neue Haftmonomere für molekular geprägte Polymere." [S.l. : s.n.], 2003. http://deposit.ddb.de/cgi-bin/dokserv?idn=968544118.

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8

Kleinsmann, Alexander Jan [Verfasser]. "Untersuchungen zur Selbstassemblierung zyklischer Dipeptide / Alexander Jan Kleinsmann." Tübingen : Universitätsbibliothek Tübingen, 2020. http://d-nb.info/1221596853/34.

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9

Majumdar, Soumyajit Mitra Ashim K. "Ocular drug delivery evaluation of dipeptide monoester ganciclovir prodrugs /." Diss., UMK access, 2005.

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Thesis (Ph. D.)--School of Pharmacy. University of Missouri--Kansas City, 2005.<br>"A dissertation in pharmaceutical sciences and pharmacology." Advisor: Ashim K. Mitra. Typescript. Vita. Title from "catalog record" of the print edition Description based on contents viewed June 26, 2006. Includes bibliographical references (leaves 174-192). Online version of the print edition.

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10

Jansson, Lennie. "Purification and refolding of a novel dipeptidyl peptidase III." Thesis, Linköpings universitet, Kemi, 2019. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-154013.

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There is a continuous search for novel enzymes to complement the abilities of today’s commercially available enzyme and find tailor-fit alternatives to suit the diverse array of bio-based industries. One application could be to increase biogas yield by finding substrate degrading proteases that can be added to the anaerobic digestion process and survive degradation themselves. A novel enzyme identified as a hypothetical dipeptidyl peptidase III, a zinc dependent metallo-protease, was found by a metaproteogenomics approach to be produced by the microorganisms of a thermophilic biogas process. T

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11

Hagemann, Diana. "Tryptophanhaltige Dipeptide als Hemmstoffe für das Angiotensin-Converting Enzyme." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2017. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-223528.

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Bluthochdruck zählt zu einer der häufigsten Zivilisationskrankheiten und ist der Hauptfaktor für die Entstehung kardiovaskulärer Erkrankungen. Das Präventionspotenzial bei Hypertonie ist sehr hoch, da lebensstilassoziierte Faktoren wie Übergewicht, hoher Kochsalz- und Alkoholkonsum oder Stress die Entstehung eines erhöhten Blutdrucks wesentlich begünstigen. Daher wird eine antihypertensive Therapie meist mit nicht-medikamentösen Maßnahmen eingeleitet. Für die Regulation des Blutdrucks ist die nähere Betrachtung des Angiotensin-Converting Enzymes (ACE) wichtig, da es eines der Schlüsselenzyme d

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12

Dökel, Sascha. "Synthese von Dipeptiden an hybriden Peptidsynthetasen." [S.l. : s.n.], 2000. http://deposit.ddb.de/cgi-bin/dokserv?idn=96239095X.

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13

Howard, Christine Michelle. "Characterization of Cyclic and Linear Dipeptides." W&M ScholarWorks, 2001. https://scholarworks.wm.edu/etd/1539626310.

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14

Batson, Sarah. "Structural enzymology of peptidoglycan biosynthetic D-amino acid dipeptide ligases." Thesis, University of Warwick, 2010. http://wrap.warwick.ac.uk/3117/.

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This thesis describes approaches to further understand the structure and enzymology of D-Ala-D-Ala ligases (DDL) and those ligases with altered second substrate specificity, which confer glycopeptide antibiotic resistance. DDL is an essential enzyme in the biosynthetic pathway of the bacterial cell wall peptidoglycan. The approaches described are based primarily on the previous transition state mimic; VanA and EcDdlB, co-crystal structures. Active site mapping of VanA by site directed mutagenesis yielded VanA mutants that were expressed and purified for kinetic studies. The active site mapping

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15

Flores, Isadora Luana 1984. "Decreased expression of angiotensinogen and dipeptidyl peptidase 1 may be associated with the development of proliferative verrucous leukoplakia = Diminuição da expressão de angiotensinogênio e dipeptidil peptidase 1 pode estar associada ao desenvolvimento de leucoplasia verrucosa proliferativa." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/287848.

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Orientador: Marcio Ajudarte Lopes<br>Tese (doutorado) - Universidade Estadual de Campinas, Faculdade de Odontologia de Piracicaba<br>Made available in DSpace on 2018-08-24T18:31:33Z (GMT). No. of bitstreams: 1 Flores_IsadoraLuana_D.pdf: 2280685 bytes, checksum: 4c70e1fe2979897700a7a4161710b445 (MD5) Previous issue date: 2014<br>Resumo: OBJETIVO: A leucoplasia verrucosa proliferativa (LVP) é uma variante rara e ainda pouco compreendida de leucoplasia oral com um comportamento de progressão persistente para malignidade apresentando uma taxa de malignização entre 40-100%. Além disso, a detecção

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16

Prokopczyk, Igor Muccilo. "Determinação da afinidade e assinatura termodinâmica de inibidores da cruzaína por calorimetria de titulação isotérmica." Universidade de São Paulo, 2016. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-09112016-153328/.

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A enzima cruzaína é um alvo validado e promissor para a descoberta de agentes tripanossomicidas. A validação desta enzima estimulou o desenvolvimento de vários inibidores ao longo dos últimos vinte anos. A descoberta de novos compostos, provenientes de classes químicas distintas, mais seguros e eficazes representa uma importante contribuição para o desenvolvimento da quimioterapia da doença de Chagas. Dentre essas classes, encontram-se as dipeptidil-nitrilas, que apresentam alta potência contra a cruzaína e são conhecidamente inibidores covalente-reversíveis. Estudos de afinidade através de Ca

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17

Helliwell, Philip Andrew. "Absorption of oligopeptide from the alveolar lumen of the adult rat lung." Thesis, University of York, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.319453.

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18

Anderson, Catriona M. H. "Intestinal proton-coupled amino acid and dipeptide transporters : function and regulation." Thesis, University of Newcastle Upon Tyne, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.398999.

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19

Tempel, Wolfram. "Synthesis and in vitro activity of proline-based ketomethylene dipeptide isoteres." Thesis, University of Salford, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.299103.

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20

Dorsey, Gordon Owen. "Design and synthesis of substituted cyclopropanes as conformationally restrained dipeptide mimics." Thesis, Austin, Texas : University of Texas at Austin, 1992. http://handle.dtic.mil/100.2/ADA252441.

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Thesis (M.A. in Chemistry)--University of Texas at Austin, May 1992.<br>"May 1992." Description based on title screen as viewed on April 8, 2009. Includes bibliographical references (p. 94-101). Also available in print.

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21

Neidrich, Keisha L. "Self-Assembly, Characterization, and Cytotoxicity Studies of a Camptothecin-Dipeptide Library." The Ohio State University, 2016. http://rave.ohiolink.edu/etdc/view?acc_num=osu1452178852.

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22

Sato, Yukiyasu. "Involvement of dipeptidyl peptidase 4 in extravillous trophoblast invasion and differentiation." Kyoto University, 2003. http://hdl.handle.net/2433/148725.

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23

Kilian, Gareth. "Development and testing of liposome encapsulated cyclic dipeptides." Thesis, Nelson Mandela Metropolitan University, 2011. http://hdl.handle.net/10948/1397.

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Cyclic dipeptides have been well characterized for their multitude of biological activities, including antimicrobial and anticancer activities. Cyclo(His-Gly) and cyclo(His-Ala) have also recently been shown to possess significant anticancer activity against a range of cell lines, despite the limitations of these two molecules with respect to their physicochemical properties. Low Log P results in poor cell permeability which can often be problematic for drugs with intracellular mechanisms of action. It can also results in poor biodistribution, and theoretical Log P values for cyclo(His-Gly) an

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24

Geier, Mark Steven. "Development and resolution of experimental colitis in dipeptidyl peptidase IV knockout mice /." Title page and abstract only, 2003. http://web4.library.adelaide.edu.au/theses/09SB/09sbg3121.pdf.

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25

Alghamdi, Ebtehal. "DFT Study on the Binding of Selected Metal Ions with Phenylalanine Dipeptide." DigitalCommons@Robert W. Woodruff Library, Atlanta University Center, 2019. http://digitalcommons.auctr.edu/cauetds/181.

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In this study, M06-2X/6-311+G(2d,2p) level calculations were performed to examine the binding energies and vibrational frequencies of different conformers of phenylalanine dipeptide interacting with metal ions (Na+, K+, Mg2+ and Ca2+). Four conformers were selected from the list of 20 most stable structures. The main goal was to understand the influence of conformers on the binding affinity of metal ions with different conformers of phenylalanine dipeptide. In agreement with experimental results, interactions of metal ions with two aromatic rings along with lone pair electrons of oxygen produc

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26

Berg, Agneta. "Glutamine to ICU patients /." Stockholm, 2007. http://diss.kib.ki.se/2007/978-91-7357-423-5/.

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27

Salles, Thiago de Almeida. "Papel da dipeptidil peptidase IV na fisiopatologia da insuficiência cardíaca." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/5/5166/tde-11012016-145338/.

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Introdução/Objetivo: Este estudo teve como objetivo testar a hipótese de que a atividade e/ou expressão da dipeptidil peptidase IV (DPPIV), uma enzima que inativa peptídeos com ações cardioreno protetoras, como o peptídeo-1 semelhante ao glucagon (GLP-1) e o peptídeo natriurético cerebral (BNP), estaria associada a um pior prognóstico na insuficiência cardíaca (HF). Métodos: Injúria do miocárdio foi realizada através da ablação do ventrículo esquerdo (VE) por radiofrequência em ratos Wistar machos (200-250 g). Os ratos foram divididos em três grupos: Sham, HF e HF + inibidor de DPPIV (sitaglip

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28

Dupont, Virginie. "Synthèse et analyse structurale de n-hydroxy peptides." Vandoeuvre-les-Nancy, INPL, 1993. http://www.theses.fr/1993INPL099N.

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Le but de cette thèse est de reconnaitre l'influence structurale de la n-hydroxylation d'une séquence peptidique. Pour cela, les homologues n-hydroxyles de dipeptides protégés à leurs extrémités par une fonction amide ont été préparés et étudiés en solution par RMN et spectroscopie ir, à l'état solide par diffraction des rayons X, et soumis à une analyse théorique par dynamique moléculaire. Le premier chapitre est un rappel des connaissances nécessaires à la compréhension de la suite. Le second chapitre décrit la synthèse des n-hydroxypeptides examinés et les méthodes d'étude structurale utili

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29

Gupta, Sona. "Rational design and delivery of peptide drugs." Thesis, Bangor University, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.323850.

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30

Venin, Claire. "Synthèse en parallèle d’hétérocycles dérivés de séquences dipeptidiques et profil d’activité inhibitrice sur les phospholipases A2 sécrétées." Thesis, Bordeaux 1, 2013. http://www.theses.fr/2013BOR14855/document.

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Le squelette 1,3,5-triazépane-2,6-dione est un hétérocycle à sept chainons dérivé de dipeptides et accessible en quatre étapes en solution. Une voie de synthèse en parallèle sur support solide de cet hétérocycle a été élaborée. Cette synthèse, qui repose sur les principes de "catch and release" et de cyclo-clivage, a permis la création d’une chimiothèque de plus d’une centaine de composés. Pour augmenter la diversité du squelette 1,3,5-triazépane-2,6-dione, des modifications post-cyclisation peuvent avoir lieu telles que des réactions de N-mono-alkylation ou de N,N-di-alkylation de l’urée, des

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31

Mason, Thomas Oliver. "Diphenylalanine self-assembly- kinetics, thermodynamics and its relevance to amyloidogenesis." Thesis, University of Cambridge, 2018. https://www.repository.cam.ac.uk/handle/1810/270613.

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Diphenylalanine (FF) is a dipeptide capable of self-assembly in aqueous solution into needle-like hollow micro- and nanocrystals that possess advantageous properties such as high stiffness and piezoelectricity and have emerged as attractive candidates for functional nanomaterials. In addition, these structures can be made conductive or used as scaffolds for organising functional entities which do not on their own possess a propensity towards self-assembly. At the start of this project, despite wide-ranging interest in the FF assemblies, many important and fundamental aspects of the system rema

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32

Kwolek, Kathleen A. "Investigation of Site-Specific Metal-Catalyzed Oxidation of Proteins Using Dipeptides as Model Compounds." Youngstown State University / OhioLINK, 2001. http://rave.ohiolink.edu/etdc/view?acc_num=ysu997720041.

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33

Ribeiro, Jean Francisco Rosa. "Inibidores de Cisteíno Proteases como Candidatos Terapêuticos para o Tratamento de Doenças Parasitárias." Universidade de São Paulo, 2018. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-10102018-160410/.

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<p align=\"justify\">A necessidade urgente de descoberta de terapias mais seguras e eficazes para o tratamento da doença de Chagas e leishmanioses tem motivado a pesquisa por novos inibidores das enzimas cruzaína e CPB, as principais cisteíno proteases do T. cruzie e Leishmania spp., respectivamente. Uma série de 52 compostos nitrílicos que atuam como inibidores covalente-reversíveis de cisteíno proteases foi sintetizada no grupo NEQUIMED/IQSC/USP e avaliada quanto a sua atividade inibitória contra as enzimas cruzaína, CPB de Leishmania mexicana e catepsina L de humanos. Utilizando planejament

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34

Yapar, Serap [Verfasser], and Stefan [Akademischer Betreuer] Kubik. "Novel Gold Nanoparticles for Dipeptide Recognition in Water / Serap Yapar ; Betreuer: Stefan Kubik." Kaiserslautern : Technische Universität Kaiserslautern, 2016. http://d-nb.info/1121587747/34.

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35

Stewart, Andrew Kenneth. "Intracellular pH regulation associated with proton-coupled dipeptide transport in mouse small intestine." Thesis, University of Oxford, 1998. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.298321.

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36

Duffy, Nicola A. "Plasma dipeptidyl peptidase IV activity : role in degradation of enteroinsular hormones and diabetes." Thesis, University of Ulster, 2004. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.414325.

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37

Breton, Pascal. "Synthese et caracterisation d'activateurs potentiels des macrophages : analogues pseudo-peptidiques du muramyl dipeptide." Orléans, 1989. http://www.theses.fr/1989ORLE2032.

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Dans le but de developper une approche immunotherapeutique anti-cancereuse, nous avons elabore une serie d'acyl-pseudopeptides non glycosyles, d'hydrophobicite variable, du type r1-xxxch#2od(l)-ala-ala-d-glulys(r2)-nhet-nh2 (r1=ac, boc ou lauroyle; xxx=gly ou ser; r2=ch#3cooh,h ou ch#3cooh,h-gly), susceptibles de stimuler efficacement l'activite anti-tumorale des macrophages et dont l'extremite n-terminale mime une partie de la structure de l'acide n-acetyl muramique contenu dans le muramyl dipeptide (mdp). La preparation de ces nouvelles molecules est decrite et, en particulier, la mise au po

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38

Wang, Flora Yinglai-Hua. "Purification and Characterization of Native and Recombinant Dipeptidyl Aminopeptidase 1 of Plasmodium falciparum." Thesis, Virginia Tech, 2008. http://hdl.handle.net/10919/42714.

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Plasmodium falciparum dipeptidyl aminopeptidase 1 (DPAP1) contributes to the degradation of hemoglobin by releasing dipeptides from globin oligopeptides in the food vacuole. The lack of success at DPAP1 gene disruption suggests that this exopeptidase is important for efficient growth during the erythrocytic asexual stage. DPAP1 is therefore an attractive target for the development of anti-malarial drugs that block the catabolism of hemoglobin. To guide the design of selective, potent DPAP1 inhibitors, it is necessary to characterize the substrate specificity of this enzyme along with its hum

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39

Hudson, Alexander Stephen. "Efforts towards the total synthesis of labelled CCL2 proteins and dipeptide chemotaxis inhibitors." Thesis, Durham University, 2015. http://etheses.dur.ac.uk/11471/.

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Chemokines such as CCL2 are small proteins with molecular weights between 8-10 kDa. They promote chemotaxis and play a vital role in the recruitment of leukocytes to the site of inflammation. Given their key biological functions, understanding their mechanism of action and inhibiting their action has therapeutic potential in a range of diseases. Selective inhibitors of CCL2 induced chemotaxis based on the diketopiperazine (DKP) natural product, cyclo(13,15-dichloro-L-Pro-L-Tyr) were recently reported by the Cobb group. In order to develop this work further and to produce an expanded library, w

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Sasselli, Iván Ramos. "Modelling Fmoc-dipeptide nanostructures : the synergistic effect of combining computational and experimental methods." Thesis, University of Strathclyde, 2015. http://oleg.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=27047.

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Nanomaterials based on aromatic peptide amphiphiles are interesting new materials with potential applications in the areas of biomedicine and nanotechnology. These natural based materials take advantage of the properties of the peptides, as it is the ability to form the final structures spontaneously without any external stimulus by self-assembly, or the high number of functionality available due to the 20 natural building blocks, amino acids, and their possible combinations. Although it is known that the functionality of these nanostructures is highly dependent on both, the chemical groups an

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41

Narumi, Tetsuo. "Synthetic studies on fluoroalkene dipeptide isosteres and their application to biologically active peptides." 京都大学 (Kyoto University), 2008. http://hdl.handle.net/2433/137143.

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42

Jamie, Hajierah. "The medicinal chemistry of the isomers of the cyclic dipeptide: cyclo(Trp-Pro)." Thesis, University of Port Elizabeth, 2002. http://hdl.handle.net/10948/281.

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The isomers of cyclo(Trp-Pro) (cyclo(L-Trp-L-Pro), cyclo(L-Trp-D-Pro), cyclo(D-Trp-LPro) and cyclo(D-Trp-D-Pro)) have been successfully synthesized and screened for biological activity. High percentage yields were obtained by using the three phase synthesis system, which involves the synthesis of the intermediate protected linear dipeptides, followed by the removal of the protecting Boc groups. This step is followed by cyclization and crystallization of the isomers. The diketopiperazines rings of cyclo(L-Trp-L-Pro) and cyclo(D-Trp-D-Pro) contain cisamide bonds, while cyclo(L-Trp-D-Pro) and cyc

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43

Reyes, Cristian David Camilo. "Síntese de dipeptidil-nitrilas como inibidores da enzíma cruzaína." Universidade de São Paulo, 2014. http://www.teses.usp.br/teses/disponiveis/75/75133/tde-29072014-153915/.

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A doença de Chagas, descrita em 1909 pelo médico sanitarista brasileiro Dr. Carlos Chagas, é causada pelo parasito Trypanosoma cruzi. É uma doença tropical negligenciada que afeta aproximadamente entre 12 e 14 milhões de indivíduos em América latina. No ano de 2008 foi responsável pela morte de cerca de 10 mil pessoas no mundo, sendo que a terapia atual consiste no uso dos fármacos benzonidazol e nifurtimox que são eficazes apenas no estágio inicial da doença (fase aguda) e ainda possuem efeitos colaterais severos. Esse quadro justifica a necessidade da busca por substâncias mais eficientes pa

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Mohajane, Mamohale. "Dipeptides as potential anti-flammatory drugs for rheumatoid arthritis." Master's thesis, University of Cape Town, 2013. http://hdl.handle.net/11427/6340.

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Includes abstract.<br>Includes bibliographical references.<br>The H⁺ and Cu²⁺ equilibria of four glycine peptides (glycyl-glycine, glycyl-L-leucine, glycyl-L-phenylalanine and glycyl-L-histidine) and four sarcosine peptides (sarcosylglycine, sarcosyl-L-leucine, sarcosyl-L-phenylalanine and sarcosyl-L-histidine) have been studied using glass electrode potentiometry and isothermal titration calorimetry at 25 °C and an ionic strength 0.15 M (NaCl). The terminal amine of the sarcosine peptides is more basic than the glycine analogues. The methyl group on the terminal amine (for sarcosine peptides)

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45

White, Colleen A. "An investigation into human serum carnosinase." Thesis, Glasgow Caledonian University, 1999. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.301471.

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Marsh, Susan E. "The physiology and pathophysiology of dipeptide transport in cultured human intestinal Caco-2 cells." Thesis, University of Aberdeen, 2002. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.248618.

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It is well established that H<sup>+</sup>-coupled dipeptide transport in the cultured intestinal cell line, Caco-2 is electrogenic and results in intracellular acidification, via the apically located transport protein, PepTl. The purpose of this study was to initially investigate both the pH dependency and electrogenic nature of H<sup>+</sup>-coupled dipeptide transport, using microspectrofluorometric analysis of intracellular pH and short circuit current (I<sub>SC</sub>) measurement of Gly-Sar transport in Caco-2 monolayers. This aimed to characterise both the apical and basolateral transport

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Solomon, Daniel Adam. "Mechanisms of G4C2 derived dipeptide repeat protein toxicity in Drosophila models of C9ALS/FTD." Thesis, King's College London (University of London), 2018. https://kclpure.kcl.ac.uk/portal/en/theses/mechanisms-of-g4c2-derived-dipeptide-repeat-protein-toxicity-in-drosophila-models-of-c9alsftd(fe890a3c-a4a0-42c7-b2fc-7780889fc2b9).html.

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A G4C2 hexanucleotide repeat expansion in the gene C9ORF72 is the most common cause of Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal dementia (FTD). Although intronic, the G4C2 repeat is translated in the absence of an ATG start codon through a mechanism known as repeat-associated non-ATG translation resulting in the production of five different dipeptide-repeat proteins (DPRs). These DPRs form inclusions in brains of C9+ ALS and FTD sufferers. Further, C9+ patients are also characterised by cytoplasmic inclusions of the protein TDP-43, whose dysfunction is causally related to ALS and

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Aldewachi, Hasan. "Chromogenic detection of dipeptidyl peptidase IV (DPP-IV) activity using peptide-functionalized gold nanoparticles." Thesis, Sheffield Hallam University, 2017. http://shura.shu.ac.uk/18152/.

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Metal nanoparticles offer a useful platform for a wide range of biological applications especially for biosensing, bioimaging and drug delivery. This thesis presents a body of original research describing the synthesis, characterisation and development of a novel and convenient biosensing assay for detection of dipeptidyl peptidase IV (DPP-IV) enzyme activity using peptide functionalized gold nanoparticles. The distinctive optical and physical properties of gold nanoparticles (Au NP) were harnessed for the development of a colorimetric assay for rapid sensing of DPP-IV activities and screening

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David, Frédéric. "Determination du role de certains residus conserves de la dipeptidyl peptidase iv de souris." Aix-Marseille 2, 1996. http://www.theses.fr/1996AIX22047.

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La dipeptidyl peptidase iv (dpp iv/cd26) est une sialoglycoproteine membranaire de type ii a l'expression ubiquiste. Cette serine protease permet de catalyser le clivage d'un dipeptide xaa-pro, ou xaa-ala, a l'extremite aminoterminale de certains oligopeptides bioactifs. De nombreux resultats experimentaux soulignent l'importance de cette enzyme dans la reponse immunitaire. Cd26 caracterise les populations de lymphocytes t les plus reactives a l'antigene. Plus qu'un simple temoin de l'activation de la cellule t, cd26 est une molecule accessoire qui facilite la transduction du signal d'activati

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Duru, Christiane. "Synthèse et études structurales d'oligomères de mimes contraints de dipeptide : recherche de nouveaux foldamères." Montpellier 2, 2005. http://www.theses.fr/2005MON20120.

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