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Journal articles on the topic 'DNA intercalating ligand'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Mamasakhlisov, A. Ye, and Ye Sh Mamasakhlisov. "THE CONDUCTIVITY OF THE MONOLAYER OF COMPLEXES OF DNA WITH QUANTUM DOTS IN THE PRESENCE OF INTERCALATING LIGANDS." Proceedings of the YSU A: Physical and Mathematical Sciences 53, no. 3 (250) (2019): 203–7. http://dx.doi.org/10.46991/pysu:a/2019.53.3.203.

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The noncompetitive DNA hybridization and conductivity in the presence of non-charged ligands have been investigated and the comparison is made with the ligand-free case. It has been shown that the intercalating ligands enhance the sensitivity of the DNA chips as compared with the ligand-free case at the high enough concentration of ligands.

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2

Sharma, Nitin Kumar, Rakesh Kumar Ameta, and Man Singh. "Biological Impact of Pd (II) Complexes: Synthesis, Spectral Characterization, In Vitro Anticancer, CT-DNA Binding, and Antioxidant Activities." International Journal of Medicinal Chemistry 2016 (February 16, 2016): 1–10. http://dx.doi.org/10.1155/2016/9245619.

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A new series of Pd (II) complexes of methyl substituted benzylamine ligands (BLs) has been synthesized and characterized via spectroscopic techniques such as UV/Vis. FTIR, LCMS, 1H, and 13C NMR. The UV/Vis study in DMSO, DMSO + water, and DMSO + PBS buffer (pH = 7.2) confirmed their molecular sustainability in liquids. Their in vitro anticancer activity against breast cancer cell lines such as MCF-7 and MDA-MB-231 makes them interesting for in vivo analysis. Their stronger DNA binding activity (DBA) compared with free ligand suggested them as a good DNA binder. DBA was further confirmed by phy

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3

Nardo, Luca, Maria Bondani, and Alessandra Andreoni. "Discrimination of the binding mode of DNA ligands by single-photon timing." Spectroscopy 23, no. 1 (2009): 11–28. http://dx.doi.org/10.1155/2009/605756.

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We perform time-correlated single-photon counting measurements with 30-ps resolution of the fluorescence emitted by the donor fluorophores of donor–acceptor pairs covalently labeling DNA synthetic oligonucleotides by using a non-commercial single-photon avalanche diode. The measurements allow us to precisely assess the fluorescence resonant energy transfer efficiency of the pairs in solutions containing the oligonucleotides and DNA–ligands, for different ratios of the DNA base-pair to ligand concentrations. A quantitative evaluation of the deformations of DNA double strands following the ligan

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4

Marverti, Gaetano, Gaia Gozzi, Angela Lauriola, et al. "The 1,10-Phenanthroline Ligand Enhances the Antiproliferative Activity of DNA-Intercalating Thiourea-Pd(II) and -Pt(II) Complexes Against Cisplatin-Sensitive and -Resistant Human Ovarian Cancer Cell Lines." International Journal of Molecular Sciences 20, no. 24 (2019): 6122. http://dx.doi.org/10.3390/ijms20246122.

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Ovarian cancer is the most lethal gynecological malignancy, often because of the frequent insurgence of chemoresistance to the drugs currently used. Thus, new therapeutical agents are needed. We tested the toxicity of 16 new DNA-intercalating agents to cisplatin (cDDP)-sensitive human ovarian carcinoma cell lines and their resistant counterparts. The compounds were the complexes of Pt(II) or Pd(II) with bipyridyl (bipy) and phenanthrolyl (phen) and with four different thiourea ancillary ligands. Within each of the four series of complexes characterized by the same thiourea ligand, the Pd(phen)

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5

Piestrzeniewicz, Mariola K., Dorota Wilmańska, Kazimierz Studzian, et al. "Inhibition of RNA Synthesis in vitro by Acridines - Relation between Structure and Activity." Zeitschrift für Naturforschung C 53, no. 5-6 (1998): 359–68. http://dx.doi.org/10.1515/znc-1998-5-610.

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Abstract The effects of acridine derivatives (proflavine and 2,7-dialkyl derivatives, diacridines and triacridines, 9-aminoacridine carboxamides, and 9-anilinoacridine, amsacrine and its congeners) on overall RNA synthesis in vitro, on synthesis of initiating oligonucleotides and the binding of the enzyme to DNA were studied. The primary mechanism of action is related to inhibition of the enzyme binding to DNA. The acridines (intercalating or non-intercalating and bis-intercalating ligands) assayed here differ in the properties of their complexes with DNA. Correlation is generally observed bet

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6

McFadyen, W. D., L. P. G. Wakelin, I. A. G. Roos, and B. L. Hillcoat. "Binuclear platinum (II)-terpyridine complexes. A new class of bifunctional DNA-intercalating agent." Biochemical Journal 238, no. 3 (1986): 757–63. http://dx.doi.org/10.1042/bj2380757.

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A series of binuclear DNA-binding ligands was prepared by linking two (2,2′:6′,2″-terpyridine)platinum(II) moieties via alpha omega-dithiols of the type HS-[CH2]n-SH where n = 4-10. A monomeric analogue was also synthesized. Compounds were characterized by elemental analysis and electronic and n.m.r. spectroscopy. Viscometric measurements with sonicated rod-like DNA fragments and covalently closed circular DNA were performed to investigate the mode of binding of these agents. The ligands with n = 5 and 6 function as bis intercalators and form a single ‘base-pair sandwich’ in violation of neigh

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7

Sakthikumar, Karunganathan, Rajadurai Vijay Solomon, and Jeyaraj Dhaveethu Raja. "Spectro-electrochemical assessments of DNA/BSA interactions, cytotoxicity, radical scavenging and pharmacological implications of biosensitive and biologically active morpholine-based metal(ii) complexes: a combined experimental and computational investigation." RSC Advances 9, no. 25 (2019): 14220–41. http://dx.doi.org/10.1039/c8ra09218d.

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Morpholine-based metal(ii) complexes exhibited more significant biological activities than the free ligand. Among investigations towards DNA/BSA, the copper complex revealed excellent intercalating efficacy, which suggests it may have potential as a novel anticancer agent.

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8

de Oliveira, Tiago Alves, Lucas Rolim Medaglia, Eduardo Habib Bechelane Maia, et al. "Evaluation of Docking Machine Learning and Molecular Dynamics Methodologies for DNA-Ligand Systems." Pharmaceuticals 15, no. 2 (2022): 132. http://dx.doi.org/10.3390/ph15020132.

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DNA is a molecular target for the treatment of several diseases, including cancer, but there are few docking methodologies exploring the interactions between nucleic acids with DNA intercalating agents. Different docking methodologies, such as AutoDock Vina, DOCK 6, and Consensus, implemented into Molecular Architect (MolAr), were evaluated for their ability to analyze those interactions, considering visual inspection, redocking, and ROC curve. Ligands were refined by Parametric Method 7 (PM7), and ligands and decoys were docked into the minor DNA groove (PDB code: 1VZK). As a result, the area

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9

Mamasakhlisov, Ye Sh, A. P. Antonyan, and A. A. Hakobyan. "EFFECT OF LIGAND BINDING ON FUNCTIONALITY OF DNA FIELD-EFFECT TRANSISTOR." Proceedings of the YSU A: Physical and Mathematical Sciences 51, no. 1 (242) (2017): 66–70. http://dx.doi.org/10.46991/pysu:a/2017.51.1.066.

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Motivated by the prospects of developing DNA field-effect transistors, as tools for a variety of application fields such as medical diagnostics, environmental pollutants monitoring, biological weapons defense, and taking into account that the efficiency of DNA-sensors depends on the precise prediction of experimental parameters responsible for thermostability of nucleic acids duplexes and specific times of formation of DNA duplexes, we analyze the factors influencing both the thermodynamics of hybridization and the stability of DNA–DNA and DNA–RNA duplexes. In this work the case of competition

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10

Petrosyan, Nara H. "STUDY OF ABSORPTION SPECTRA OF THE COMPLEXES OF BOVINE SERUM ALBUMIN WITH HOECHST 33258 AND METHYLENE BLUE." Proceedings of the YSU B: Chemical and Biological Sciences 55, no. 2 (255) (2021): 158–64. http://dx.doi.org/10.46991/pysu:b/2021.55.2.158.

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The study on the interaction of DNA-specific low-molecular compounds – groove binding material Hoechst 33258 and intercalating ligand methylene blue (MB) with serum albumin has been carried out. The absorption and differential absorption spectra of complexes of the mentioned ligands with protein were obtained. Changes of the absorption and differential absorption spectra indicate the binding of two ligands with albumin. The obtained results indicate that at the interaction with both ligands, the conformational state of the protein alters, though these changes are not similar, since in the case

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11

Kapuscinski, J. "Interactions of nucleic acids with fluorescent dyes: spectral properties of condensed complexes." Journal of Histochemistry & Cytochemistry 38, no. 9 (1990): 1323–29. http://dx.doi.org/10.1177/38.9.1696951.

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Interaction of cations with nucleic acids (NA) often results in condensation of the product. The driving force of aromatic cation-induced condensation is the cooperative interaction between ligand and single-stranded (ss) NA. This type of reaction is highly specific with regard to the primary and secondary structure of NA, and results in destabilization of the latter. The spectral properties of fluorescent intercalating and non-intercalating ligands [acridine orange, pyronin Y(G), DAPI, Hoechst 33258, and Hoechst 33342]-NA complexes were studied in both the relaxed and condensed form. The chan

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12

James, Marisa, Madelyn R. Shevlin, Thomas B. Green, Megan M. Smart, Colin D. McMillen, and Jared A. Pienkos. "Crystal Structures of DNA Intercalating Agents Dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq), (Benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), and [Ir(ppy)2(dppn)][PF6] (Where Hppy = 2-Phenylpyridine)." Inorganics 11, no. 9 (2023): 353. http://dx.doi.org/10.3390/inorganics11090353.

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Pyrazino-phenanthroline ligands are commonly used with transition metals as DNA intercalation agents. Herein, we report the characterization of two commonly utilized pyrazino-phenanthroline ligands, dipyrido[3,2-f:2′,3′-h]quinoxaline (dpq) and (benzo[i]dipyrido[3,2-a:2′,3′c]phenazine (dppn), by single-crystal X-ray diffraction. Additionally, the characterization of [Ir(ppy)2(dppn)][PF6], where Hppy = 2-phenylpyridine, by single-crystal X-ray diffraction is described. Both the dpq and dppn ligands crystallize as chloroform solvates where the chloroform molecule occupies the equivalent binding p

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13

Galo, André Luiz, and Márcio Francisco Colombo. "Singular Value Decomposition and Ligand Binding Analysis." Journal of Spectroscopy 2013 (2013): 1–7. http://dx.doi.org/10.1155/2013/372596.

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Singular values decomposition (SVD) is one of the most important computations in linear algebra because of its vast application for data analysis. It is particularly useful for resolving problems involving least-squares minimization, the determination of matrix rank, and the solution of certain problems involving Euclidean norms. Such problems arise in the spectral analysis of ligand binding to macromolecule. Here, we present a spectral data analysis method using SVD (SVD analysis) and nonlinear fitting to determine the binding characteristics of intercalating drugs to DNA. This methodology re

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14

TAKENAKA, Shigeori, Yosuke FUNATU, Naonori SHIGEMOTO, and Hiroki KONDO. "Discrimination of the length of double-stranded DNA fragments by the bis-intercalating ligand." Analytical Sciences 13, Supplement (1997): 177–80. http://dx.doi.org/10.2116/analsci.13.supplement_177.

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15

Lawrence Arockiasamy, D., S. Radhika, R. Parthasarathi, and Balachandran Unni Nair. "Synthesis and DNA-binding studies of two ruthenium(II) complexes of an intercalating ligand." European Journal of Medicinal Chemistry 44, no. 5 (2009): 2044–51. http://dx.doi.org/10.1016/j.ejmech.2008.10.013.

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16

Colgrave, Michelle L., Paula Iannitti-Tito, Geoffrey Wickham, and Margaret M. Sheil. "Rapid Determination of Sequence Selectivity and Stability of Alkylated Oligonucleotide Adducts by Electrospray Tandem Mass Spectrometry." Australian Journal of Chemistry 56, no. 5 (2003): 401. http://dx.doi.org/10.1071/ch02205.

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The binding of the antitumor antibiotics, duocarmycin C2 (pyrindamycin A), duocarmycin C1 (pyrindamycin B), hedamycin, and DC92-B to self complementary oligonucleotides (ranging from 6 to 14-mers) has been studied using electrospray ionization mass spectrometry (ESI-MS) and tandem mass spectrometry (MS/MS). The duocarmycins bind via non-covalent interactions in the minor groove of DNA with subsequent alkylation of the N3 atom of adenine. Hedamycin and DC92-B are intercalating, alkylating agents that target the N7 of guanines within 5′-CGT, and to a lesser extent, 5′-CGG sequences. We show here

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17

Vandiver, M. Scott, E. Page Bridges, Ryan L. Koon, et al. "Effect of Ancillary Ligands on the DNA Interaction of [Cr(diimine)3]3+Complexes Containing the Intercalating Dipyridophenazine Ligand." Inorganic Chemistry 49, no. 3 (2010): 839–48. http://dx.doi.org/10.1021/ic9013619.

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18

Vaidyanathan, Vaidyanathan Ganesan, and Balachandran Unni Nair. "Synthesis, characterization and binding studies of chromium(III) complex containing an intercalating ligand with DNA." Journal of Inorganic Biochemistry 95, no. 4 (2003): 334–42. http://dx.doi.org/10.1016/s0162-0134(03)00132-6.

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19

Naeem, Muhammad, Saqib Ali, Saira Shahzadi, et al. "Synthesis, Characterization and DNA Binding Studies of Zn(II)/Cu(II) Complexes with 2,2`-Diphenyl Acetic Acid/2-(4-Hydroxyphenyl)Acetic Acid Ligand Precursors and Nitrogen Bases." Academic Journal of Chemistry, no. 51 (January 25, 2019): 1–9. http://dx.doi.org/10.32861/ajc.51.1.9.

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The hydrated complexes 1, 3, 7 and 8 with the general formula (RCOO)2M.xH2O (where M = Zn & x = 6; M = Cu & x = 5,6) were synthesized by the reaction of sodium salt of 2,2`-diphenyl acetic acid or 2-(4-hydroxyphenyl)acetic acid (RCOONa) with Zn(NO3)2.6H2O or CuSO4.5H2O in an aqueous medium. The addition of methanolic solution of either bipyridine (bpy) or 1,10-phenanthroline (phen) to an aqueous suspension of 1, 3, 7 and 8 (produced in situ) result in the formation of mixed ligand products with the general formulae (RCOO)2M(bpy).xH2O (2, 4, 9 and 10) and (RCOO)2M(phen).xH2O (5 and 6).

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20

Savić, Aleksandar, Anna M. Kaczmarek, Rik Van Deun, and Kristof Van Hecke. "DNA Intercalating Near-Infrared Luminescent Lanthanide Complexes Containing Dipyrido[3,2-a:2′,3′-c]phenazine (dppz) Ligands: Synthesis, Crystal Structures, Stability, Luminescence Properties and CT-DNA Interaction." Molecules 25, no. 22 (2020): 5309. http://dx.doi.org/10.3390/molecules25225309.

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In order to create near-infrared (NIR) luminescent lanthanide complexes suitable for DNA-interaction, novel lanthanide dppz complexes with general formula [Ln(NO3)3(dppz)2] (Ln = Nd3+, Er3+ and Yb3+; dppz = dipyrido[3,2-a:2′,3′-c]phenazine) were synthesized, characterized and their luminescence properties were investigated. In addition, analogous compounds with other lanthanide ions (Ln = Ce3+, Pr3+, Sm3+, Eu3+, Tb3+, Dy3+, Ho3+, Tm3+, Lu3+) were prepared. All complexes were characterized by IR spectroscopy and elemental analysis. Single-crystal X-ray diffraction analysis of the complexes (Ln

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21

Liu, Yao, Richard Hammitt, Daniel A. Lutterman, Randolph P. Thummel, and Claudia Turro. "Marked Differences in Light-Switch Behavior of Ru(II) Complexes Possessing a Tridentate DNA Intercalating Ligand." Inorganic Chemistry 46, no. 15 (2007): 6011–21. http://dx.doi.org/10.1021/ic700484j.

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22

Zubair, M. Sulaiman, and Subehan Subehan. "Molecular Docking of Lunacridine from Lunasia amara to DNA : Its Inhibition And Interaction Study Correlated With The Cytotoxic Activity on P388 Murine Leukemia Cells." Indonesian Journal of Cancer Chemoprevention 1, no. 2 (2010): 108. http://dx.doi.org/10.14499/indonesianjcanchemoprev1iss2pp108-117.

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DNA Topoisomerase II inhibitors are a type of anticancer drugs. These drugs perform their biological activity either by forming a DNA-intercalator-topoisomerase II ternary complex or by inhibiting other enzymes and/or transcription factors that act on DNA. The strong interactions with DNA play a crucial role for their pharmacological properties. Lunacridine, the active principle from Lunasia amara, was known as DNA intercalating Topoisomerase II inhibitor. With the aims to explore the affinity and molecular interaction of lunacridine compound isolated from Lunasia amara with DNA, molecular doc

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23

Shahabadi, Nahid, and Maryam Mahdavi. "DNA Interaction Studies of a Cobalt(II) Mixed-Ligand Complex Containing Two Intercalating Ligands: 4,7-Dimethyl-1, 10-Phenanthroline and Dipyrido[3,2-a:2′,3′-c]phenazine." ISRN Inorganic Chemistry 2013 (December 30, 2013): 1–7. http://dx.doi.org/10.1155/2013/604218.

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A new cobalt(II) complex [Co(dppz)2(4,7-dmp)]2+ (4,7-dmp = 4,7-dimethyl-1,10-phenanthrolline) and dppz = dipyrido[3,2-a:2′-3′-c]phenazine has been synthesized and characterized by elemental analysis (CHN), FT-IR, and UV-visible (UV-Vis) spectroscopic techniques. The DNA-binding property of the complex has been investigated employing absorption spectroscopy, fluorescence spectroscopy, circular dichroism, and viscosity measurements. The experimental results show that the complex can bind to DNA in an intercalation mode. In comparison with previous study, the DNA-binding affinity of [Co(dppz)2(4,

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24

Liu, Jingli, Hui Guo, Jing Zhou, et al. "Evodiamine and Rutaecarpine as Potential Anticancer Compounds: A Combined Computational Study." International Journal of Molecular Sciences 23, no. 19 (2022): 11513. http://dx.doi.org/10.3390/ijms231911513.

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Evodiamine (EVO) and rutaecarpine (RUT) are the main active compounds of the traditional Chinese medicinal herb Evodia rutaecarpa. Here, we fully optimized the molecular geometries of EVO and RUT at the B3LYP/6-311++G (d, p) level of density functional theory. The natural population analysis (NPA) charges, frontier molecular orbitals, molecular electrostatic potentials, and the chemical reactivity descriptors for EVO and RUT were also investigated. Furthermore, molecular docking, molecular dynamics simulations, and the analysis of the binding free energies of EVO and RUT were carried out again

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25

Hall, J. P., K. O'Sullivan, A. Naseer, J. A. Smith, J. M. Kelly, and C. J. Cardin. "Structure determination of an intercalating ruthenium dipyridophenazine complex which kinks DNA by semiintercalation of a tetraazaphenanthrene ligand." Proceedings of the National Academy of Sciences 108, no. 43 (2011): 17610–14. http://dx.doi.org/10.1073/pnas.1108685108.

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26

Alsaeedi, Mona S., Bandar A. Babgi, Mostafa A. Hussien, Magda H. Abdellattif, and Mark G. Humphrey. "DNA-Binding and Anticancer Activity of Binuclear Gold(I) Alkynyl Complexes with a Phenanthrenyl Bridging Ligand." Molecules 25, no. 5 (2020): 1033. http://dx.doi.org/10.3390/molecules25051033.

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3,6-Diethynyl-9,10-diethoxyphenanthrene (4) was synthesized from phenanthrene and employed in the synthesis of the binuclear gold(I) alkynyl complexes (R3P)Au(C≡C–3-[C14H6-9,10-diethoxy]-6–C≡C)Au(PR3) (R = Ph (5a), Cy (5b)). The diyne 4 and complexes 5a and 5b were characterized by NMR spectroscopy, mass spectrometry, and elemental analysis. UV-Vis spectroscopy studies of the metal complexes and precursor diyne show strong π → π* transitions in the near UV region that red shift by ca. 50 nm upon coordination at the gold centers. The emission spectrum of 4 shows an intense fluorescence band cen

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27

Ng, Chew Hee, King Chow Kong, Sze Tin Von, et al. "Synthesis, characterization, DNA-binding study and anticancer properties of ternary metal(ii) complexes of edda and an intercalating ligand." Dalton Trans., no. 4 (2008): 447–54. http://dx.doi.org/10.1039/b709269e.

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28

Zhang, Zhen-Qian, Hong Li, Juan Xu, et al. "DNA intercalating studies of [Ru(bpy)2HPIP]2+ with intramolecular hydrogen bond ligand based on introduction of copper ion." Transition Metal Chemistry 32, no. 6 (2007): 776–80. http://dx.doi.org/10.1007/s11243-007-0249-8.

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29

Toneatto, Judith, Rodolfo A. Boero, Guadalupe Lorenzatti, Ana M. Cabanillas, and Gerardo A. Argüello. "New insights in the DNA-[Cr(phen)2(dppz)]3+ binding and photocleavage properties by the complex with an intercalating ligand." Journal of Inorganic Biochemistry 104, no. 7 (2010): 697–703. http://dx.doi.org/10.1016/j.jinorgbio.2010.02.010.

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30

Pavlović, Marijana, Stefan Nikolić, Nevenka Gligorijević, et al. "New organoruthenium compounds with pyrido[2′,3′:5,6] pyrazino[2,3‑f][1, 10]phenanthroline: synthesis, characterization, cytotoxicity, and investigation of mechanism of action." JBIC J Biol Inorg Chem 24, no. 2 (2019): 297–310. https://doi.org/10.1007/s00775-019-01647-4.

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Three new ruthenium(II)-arene complexes with pyrido[2′,3′:5,6]pyrazino[2,3-f][1, 10]phenanthroline (ppf) of general formula: C1 ([(ƞ6-benzene)Ru(ppf)Cl]PF6, C2 ([(ƞ6-toluene)Ru(ppf)Cl]PF6) and C3 ([(ƞ6-p-cymene)Ru(ppf)Cl]PF6) have been synthesized. The structures of complexes were determined by elemental analysis, IR, ESI–MS, as well as with 1H and 13C NMR spectroscopy. Cytotoxic activity has been evaluated in three different human neoplastic cell lines (A549, A375, LS 174T) and in one human non-tumor cell line (MRC-5), by the MTT assay. Complexes C1–C3 showed IC50 valu

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Ghosh, Subhajit, Tapas Das, Shishu K. Suman, Chandan Kumar, Haladhar D. Sarma, and Ashutosh Dash. "Targeted Tumor Therapy with Radiolabeled DNA Intercalator: A Possibility? Preclinical Investigations with 177Lu-Acridine." BioMed Research International 2020 (July 25, 2020): 1–13. http://dx.doi.org/10.1155/2020/9514357.

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Objective. A DNA intercalating agent reversibly stacks between the adjacent base pairs of DNA and thus is expected to exhibit preferential localization in the tumorous lesions as tumors are associated with enhanced DNA replication. Therefore, radiolabeled DNA intercalators are supposed to have potential to be used in targeted tumor therapy. Working in this direction, an attempt was made to radiolabel 9-aminoacridine, a DNA intercalator, with 177Lu, one of the most useful therapeutic radionuclides, and study the potential of 177Lu-acridine in targeted tumor therapy. Experiments. 9-Aminoacridine

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32

Sykuła, Anna, Elżbieta Łodyga-Chruścińska, Eugenio Garribba, et al. "From the Physicochemical Characteristic of Novel Hesperetin Hydrazone to Its In Vitro Antimicrobial Aspects." Molecules 27, no. 3 (2022): 845. http://dx.doi.org/10.3390/molecules27030845.

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Microorganisms are able to give rise to biofilm formation on food matrixes and along food industry infrastructures or medical equipment. This growth may be reduced by the application of molecules preventing bacterial adhesion on these surfaces. A new Schiff base ligand, derivative of hesperetin, HABH (2-amino-N′-(2,3-dihydro-5,7-dihydroxy-2-(3-hydroxy-4-methoxyphenyl)chromen-4-ylidene)benzohydrazide), and its copper complex, CuHABH [CuLH2(OAc)], were designed, synthesized and analyzed in terms of their structure and physicochemical properties, and tested as antibacterial agents. Their structur

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33

Wu, Jian-Zhong, and Li Yuan. "Synthesis and DNA interaction studies of a binuclear ruthenium(II) complex with 2,9-bis(2-imidazo[4,5- f ][1,10]phenanthroline)-1,10-phenanthroline as bridging and intercalating ligand." Journal of Inorganic Biochemistry 98, no. 1 (2004): 41–45. http://dx.doi.org/10.1016/j.jinorgbio.2003.08.011.

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34

Franco, Duvan, Attilio V. Vargiu, and Alessandra Magistrato. "Ru[(bpy)2(dppz)]2+ and Rh[(bpy)2(chrysi)]3+ Targeting Double Strand DNA: The Shape of the Intercalating Ligand Tunes the Free Energy Landscape of Deintercalation." Inorganic Chemistry 53, no. 15 (2014): 7999–8008. http://dx.doi.org/10.1021/ic5008523.

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35

Monaco, Regina R. "Capture of a Transition State Using Molecular Dynamics: Creation of an Intercalation Site in dsDNA with Ethidium Cation." Journal of Nucleic Acids 2010 (2010): 1–4. http://dx.doi.org/10.4061/2010/702317.

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The mechanism of intercalation and the ability of double stranded DNA (dsDNA) to accommodate a variety of ligands in this manner has been well studied. Proposed mechanistic steps along this pathway for the classical intercalator ethidium have been discussed in the literature. Some previous studies indicate that the creation of an intercalation site may occur spontaneously, with the energy for this interaction arising either from solvent collisions or soliton propagation along the helical axis. A subsequent 1D diffusional search by the ligand along the helical axis of the DNA will allow the lig

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36

Piosik, Jacek, Kacper Wasielewski, Anna Woziwodzka, Wojciech Śledź, and Anna Gwizdek-Wiśniewska. "De-intercalation of ethidium bromide and propidium iodine from DNA in the presence of caffeine." Open Life Sciences 5, no. 1 (2010): 59–66. http://dx.doi.org/10.2478/s11535-009-0077-2.

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AbstractCaffeine (CAF) is capable of interacting directly with several genotoxic aromatic ligands by stacking aggregation. Formation of such hetero-complexes may diminish pharmacological activity of these ligands, which is often related to its direct interaction with DNA. To check these interactions we performed three independent series of spectroscopic titrations for each ligand (ethidium bromide, EB, and propidium iodine, PI) according to the following setup: DNA with ligand, ligand with CAF and DNA-ligand mixture with CAF. We analyzed DNA-ligand and ligand-CAF mixtures numerically using wel

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Saenz-Méndez, Patricia, Rita C. Guedes, Daniel J. V. A. dos Santos, and Leif A. Eriksson. "Theoretical Study of Sequence Selectivity and Preferred Binding Mode of Psoralen with DNA." Research Letters in Physical Chemistry 2007 (November 7, 2007): 1–5. http://dx.doi.org/10.1155/2007/60623.

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Psoralen interaction with two models of DNA was investigated using molecular mechanics and molecular dynamics methods. Calculated energies of minor groove binding and intercalation were compared in order to define a preferred binding mode for the ligand. We found that both binding modes are possible, explaining the low efficiency for monoadduct formation from intercalated ligands. A comparison between the interaction energy for intercalation between different base pairs suggests that the observed sequence selectivity is due to favorable intercalation in 5′-TpA in (AT)n sequences.

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Hudecova, Lenka, Klaudia Jomova, Peter Lauro, et al. "Antimicrobial and antifungal activities of bifunctional cooper(ii) complexes with non-steroidal anti-inflammatory drugs, flufenamic, mefenamic and tolfenamic acids and 1,10-phenanthroline." Open Chemistry 18, no. 1 (2020): 1444–51. http://dx.doi.org/10.1515/chem-2020-0180.

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AbstractCooper(ii) complexes represent a promising group of compounds with antimicrobial and antifungal properties. In the present work, a series of Cu(ii) complexes containing the non-steroidal anti-inflammatory drugs, tolfenamic acid, mefenamic acid and flufenamic acid as their redox-cycling functionalities, and 1,10-phenanthroline as an intercalating component, has been studied. The antibacterial activities of all three complexes, [Cu(tolf-O,O′)2(phen)] (1), [Cu(mef-O,O′)2(phen)] (2) and [Cu(fluf-O,O′)2(phen)] (3), were tested against the prokaryotic model organisms Escherichia coli (E. col

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Liu, Yongchun, Zhengyin Yang, Kejun Zhang, Yun Wu, Jihua Zhu, and Tianlin Zhou. "Crystal Structures, Antioxidation, and DNA Binding Properties of SmIII Complexes." Australian Journal of Chemistry 64, no. 3 (2011): 345. http://dx.doi.org/10.1071/ch10302.

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The dinuclear SmIII complexes with 1:1 metal to ligand stoichiometry were prepared from Sm(NO3)3·6H2O and three anionic tetradentate Schiff-base ligands derived from 8-hydroxyquinoline-2-carboxyaldehyde with benzoylhydrazine, 2-hydroxybenzoylhydrazine, and isonicotinylhydrazine, respectively. All the ligands and complexes can bind strongly to calf thymus DNA through intercalation with the binding constants at 105–106 M–1, but complexes present stronger affinities to DNA than ligands. All the ligands and complexes have strong abilities of antioxidation, but complexes and ligands containing an a

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Liang-Nian, Ji, and Liu Jin-Gang. "Polypyridyl ruthenium complexes binding with nucleic acids." Journal of Indian Chemical Society Vol. 78, Oct-Dec 2001 (2001): 499–508. https://doi.org/10.5281/zenodo.5902237.

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Department of Chemistry, Zhongshan University, Guangzhou, 510275, P<strong>. </strong>R.China <em>E-mail : </em>cesjln@zsu.edu.cn   <em>Fax : </em>0086-20-84035497 Department of Chemistry, Tongji University, Shanghai, 200092, P. R. China <em>Manuscript received 17 July 2000</em> The binding mechanism and interactions between the octahedral polypyridyl ruthenium(II) complexes and DNA are reviewed. The influence of ligands including the intercalative ligand and the ancillary ligands on DNA-binding behavior, enantioselectivity, the nonradioactive nucleic acids probes and DNA molecular l

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S., Iyyam Pillai* C. Joel K. VIjayaraghavan and S. Subramanian. "METAL BASED PHARMACOLOGICALLY DYNAMIC MIXED LIGAND CU (II), NI (II) AND ZN (II) COMPLEXES: SYNTHESIS, SPECTRAL AND DNA INTERACTION INVESTIGATION." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 10 (2018): 10816–30. https://doi.org/10.5281/zenodo.1470665.

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<em>Small inorganic complexes that can interact with DNA or other biological molecules have tremendous conservation. The Schiff base mixed ligand L and its complexes have been characterized with the aid of elemental analysis, FT-IR, NMR, Mass, elemental analysis and electronic studies. Binding interaction of this complex with calf thymus (CT-DNA) has been investigated by emission, absorption, circular dichroism, and viscosity techniques. The complex displays significant binding properties to the CT-DNA. In fluorimeteric analysis, the binding mode of the complex with CT-DNA was investigated usi

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Kölsch, Sarah, Heiko Ihmels, Jochen Mattay, Norbert Sewald, and Brian O. Patrick. "Reversible photoswitching of the DNA-binding properties of styrylquinolizinium derivatives through photochromic [2 + 2] cycloaddition and cycloreversion." Beilstein Journal of Organic Chemistry 16 (January 23, 2020): 111–24. http://dx.doi.org/10.3762/bjoc.16.13.

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It was demonstrated that styrylquinolizinium derivatives may be applied as photoswitchable DNA ligands. At lower ligand:DNA ratios (≤1.5), these compounds bind to duplex DNA by intercalation, with binding constants ranging from K b = 4.1 × 104 M to 2.6 × 105 M (four examples), as shown by photometric and fluorimetric titrations as well as by CD and LD spectroscopic analyses. Upon irradiation at 450 nm, the methoxy-substituted styrylquinolizinium derivatives form the corresponding syn head-to-tail cyclobutanes in a selective [2 + 2] photocycloaddition, as revealed by X-ray diffraction analysis

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43

Liang-Nian, Ji, and Liu Jin-Gang. "Polypyridyl ruthenium complexes binding with nucleic acids." Journal of Indian Chemical Society Vol. 78, October-December 2001 (2001): 499–508. https://doi.org/10.5281/zenodo.5878741.

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Department of Chemistry, Zhongshan University, Guangzhou, 510275, P. R.China <em>E-mail</em>: cesjln@zsu.edu.cn   <em> Fax</em> : 0086-20-84035497 Department of Chemistry, Tongji University, Shanghai, 200092, P. R. China <em>Manuscript received 17 July 2000</em> The binding mechanism and interactions between the octahedral polypyridyl ruthenium(ll) complexes and DNA are reviewed. ·The influence of ligands including the intercalativc ligand and the ancillary ligands on DNA-binding behavior, enantioselectivity, the nonradioactive nucleic acids probes and DNA molecular light swit

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Tan, Lifeng, Xuejiao Chen, and Jianliang Sheng. "Synthesis, Characterization, DNA-Binding, and DNA-Photocleavage Properties of RuII Complexes." Australian Journal of Chemistry 62, no. 12 (2009): 1646. http://dx.doi.org/10.1071/ch09075.

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A new polypyridyl ligand 2-benzo[b]thiophen-3-yl-1H-1,3,7,8-tetraazacyclopenta[l]phenanthrene (BTCP) and its RuII complexes [Ru(bpy)2(BTCP)]2+ (1) (bpy = 2,2′-bipyridine), [Ru(phen)2(BTCP)]2+ (2) (phen = 1,10-phenanthroline), and [Ru(dmb)2(BTCP)]2+ (3) (dmb = 4,4′-dimethyl-2,2′-bipyridine), have been synthesized and characterized. The DNA-binding properties of the three complexes were investigated by spectroscopic methods and viscosity measurements. The results indicate that complexes 1, 2, and 3 bind to DNA by an intercalative mode and the ancillary ligands have a significant effect on the bi

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ALI FATHIMA, S. SYED, and M. MOHAMED SAHUL MEERAN. "Synthesis, Characterization, DNA Synergy and Molecular Docking Studies of Novel 1,10-Phenanthroline Derived Mixed Ligand Metal(II) Complexes." Asian Journal of Chemistry 35, no. 10 (2023): 2336–48. http://dx.doi.org/10.14233/ajchem.2023.28051.

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The effect of tumour and all its related costs, both human and commercial factor is driving the exploration for novel curative medicines.Although platinum-based anticancer drugs have shown considerable success, their use is complicated by a number of drawbacks. Therefore, this study is mainly designed for transition metal complex based chemotherapeutic agents to reduce the obstacles for platinum-based anticancer agents presently used. Herein, novel mixed ligand-metal(II) complexes derived from 9-anthraldehyde, 2-aminophenol, metal chlorides and 1,10-phenanthroline (co-ligand) were synthesized

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Banasiak, Anna, Nicolò Zuin Fantoni, Andrew Kellett, and John Colleran. "Mapping the DNA Damaging Effects of Polypyridyl Copper Complexes with DNA Electrochemical Biosensors." Molecules 27, no. 3 (2022): 645. http://dx.doi.org/10.3390/molecules27030645.

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Several classes of copper complexes are known to induce oxidative DNA damage that mediates cell death. These compounds are potentially useful anticancer agents and detailed investigation can reveal the mode of DNA interaction, binding strength, and type of oxidative lesion formed. We recently reported the development of a DNA electrochemical biosensor employed to quantify the DNA cleavage activity of the well-studied [Cu(phen)2]2+ chemical nuclease. However, to validate the broader compatibility of this sensor for use with more diverse—and biologically compatible—copper complexes, and to probe

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Tan, Mingxiong, Jinchan Zhu, Yingming Pan, et al. "Synthesis, Cytotoxic Activity, and DNA Binding Properties of Copper (II) Complexes with Hesperetin, Naringenin, and Apigenin." Bioinorganic Chemistry and Applications 2009 (2009): 1–9. http://dx.doi.org/10.1155/2009/347872.

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Complexes of copper (II) with hesperetin, naringenin, and apigenin of general composition[CuL2(H2O)2]⋅nH2O(1–3) have been synthesized and characterized by elemental analysis, UV-Vis, FT-IR, ESI-MS, and TG-DTG thermal analysis. The free ligands and the metal complexes have been tested in vitro against human cancer cell lines hepatocellular carcinoma (HepG-2), gastric carcinomas (SGC-7901), and cervical carcinoma (HeLa). Complexes1and3were found to exhibit growth inhibition of SGC-7901 and HepG2 cell lines with respect to the free ligands; the inhibitory rate of complex1is 43.2% and 43.8%, while

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Tang, Xia, Shanshan Mao, Xinkui Shi, Kesheng Shen, and Huilu Wu. "Synthesis, crystal structure and biological activities of a Ag(I) complex based on the V-shaped ligand 1,3-bis(1-benzylbenzimidazol-2-yl)-2-thiapropane." Zeitschrift für Naturforschung B 72, no. 4 (2017): 281–88. http://dx.doi.org/10.1515/znb-2016-0233.

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AbstractA new silver(I) complex with 1,3-bis(1-benzylbenzimidazol-2-yl)-2-thiapropane (bbbt) and crotonate ligands, with composition [Ag(bbbt)(crotonate)]·CH3CH2OH, has been synthesized and characterized by physicochemical and spectroscopic methods. Single-crystal X-ray diffraction revealed that the coordination environment of the silver(I) center can be described as a distorted tetrahedral geometry, the Ag(I) atom being coordinated by two oxygen atoms from a crotonate anion and two nitrogen atoms from a bbbt ligand. Experimental studies of the DNA-binding properties indicated that the free li

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Shu, Xu-gang, Chun-li Wu, Cui-jin Li, Min Zhang, Ke Wan, and Xin Wu. "Synthesis, Crystal Structure, Spectroscopic Properties, and Interaction with Ct-DNA of Zn(II) with 2-Aminoethanethiol Hydrochloride Ligand." Bioinorganic Chemistry and Applications 2016 (2016): 1–7. http://dx.doi.org/10.1155/2016/2691253.

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The zinc(II) complex (C2H6NS)2Zn·ZnCl2was synthesized with 2-aminoethanethiol hydrochloride and zinc sulfate heptahydrate as the raw materials in aqueous solution. The composition and structure of the complex were characterized by elemental analysis, infrared spectra, single crystal X-ray diffraction, and thermogravimetry. The crystal structure of the zinc(II) complex belongs to monoclinic system, space groupP 21/n, with cell parameters ofa= 0.84294(4),b= 0.83920(4),c= 1.65787(8) nm,Z=2, andD= 2.041 g/cm3. In this paper, the interaction of complex with Ct-DNA was investigated by UV-visible and

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Deng, Qianjun, Zitian Tang, Ruixue Liu, Yuan Liu, Huaxuan Liang, and Yancheng Liu. "(Z)-2-(2-(Anthracen-9-ylmethylene)hydrazineyl)pyrimidine-rhodium(III): Crystal Structure and DNA Binding Property." Crystals 12, no. 11 (2022): 1664. http://dx.doi.org/10.3390/cryst12111664.

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A new rhodium(III) complex of a 9-anthrahydrazone ligand ((Z)-2-(2-(Anthracen-9-ylmethylene)hydrazineyl)pyrimidine, 9-PMAH) is six-coordinated respectively by one bidentate ligand, one solvent DMSO, and three chlorides, to form a distorted octahedral coordination geometry. The ligand chelates to Rh(III) via the hydrazone N atom (N1) and pyrimidine N atom (N3), whereas DMSO coordinates to Rh(III) via the S atom. The three chloride ligands (Cl1, Cl2, and Cl3) are in a mer-configuration of the octahedron, with the DMSO cis- to the pyrimidine nitrogen. In solution, the complex may exist in the pos

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