Log in

Relevant bibliographies by topics / Drug delivery in cancer therapy / Dissertations / Theses

To see the other types of publications on this topic, follow the link: Drug delivery in cancer therapy.

Dissertations / Theses on the topic 'Drug delivery in cancer therapy'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 dissertations / theses for your research on the topic 'Drug delivery in cancer therapy.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.

1

Yung, Bryant Chinung. "NANOPARTICLE DRUG DELIVERY SYSTEMS FOR CANCER THERAPY." The Ohio State University, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=osu1417614665.

Full text

APA, Harvard, Vancouver, ISO, and other styles

2

Zi, Hong. "Polymers for drug delivery in cancer therapy /." May be available electronically:, 2008. http://proquest.umi.com/login?COPT=REJTPTU1MTUmSU5UPTAmVkVSPTI=&clientId=12498.

Full text

APA, Harvard, Vancouver, ISO, and other styles

3

Liu, Yang. "Development of Novel Drug Delivery Systems for Cancer Therapy." The Ohio State University, 2018. http://rave.ohiolink.edu/etdc/view?acc_num=osu153105342400785.

Full text

APA, Harvard, Vancouver, ISO, and other styles

4

Xu, Leyuan. "Engineering of Polyamidoamine Dendrimers for Cancer Therapy." VCU Scholars Compass, 2015. http://scholarscompass.vcu.edu/etd/3773.

Full text

Abstract:

Dendrimers are a class of polymers with a highly branched, three-dimensional architecture comprised of an initiator core, several interior layers of repeating units, and multiple active surface terminal groups. Dendrimers have been recognized as the most versatile compositionally and structurally controlled nanoscale building blocks for drug and gene delivery. Polyamidoamine (PAMAM) dendrimers have been most investigated because of their unique structures and properties. Polycationic PAMAM dendrimers form compacted polyplexes with nucleic acids at physiological pH, holding great potential for

APA, Harvard, Vancouver, ISO, and other styles

5

Qin, Yiru. "Graphene Quantum Dots-Based Drug Delivery for Ovarian Cancer Therapy." Scholar Commons, 2016. http://scholarcommons.usf.edu/etd/6358.

Full text

Abstract:

Ovarian cancer, one of the most dreadful malignancies of the female reproductive system, poses a lethal threat to women worldwide. In this dissertation, the objective was to introduce a novel type of graphene quantum dots (GQDs) based nano-sized drug delivery systems (DDS) for ovarian cancer treatment. As a starting point, the facile synthesis method of the GQDs was established. Subsequently, the targeting ligand,folic acid (FA), was conjugated to GQDs. Next, a FDA approved chemotherapeutic drug, Doxorubicin (DOX), was loaded to form the GQDs-FA-DOX nano-conjugation as the DDS. Moreover, the u

APA, Harvard, Vancouver, ISO, and other styles

6

Man, Kwun-wai Dede, and 文冠慧. "Oleanolic acid delivery using biodegradable nanoparticles for cancer therapy." Thesis, The University of Hong Kong (Pokfulam, Hong Kong), 2015. http://hdl.handle.net/10722/208550.

Full text

APA, Harvard, Vancouver, ISO, and other styles

7

Escolà, Jané Anna. "Somatostatin analogues as drug delivery systems for receptor-targeted cancer therapy." Doctoral thesis, Universitat de Barcelona, 2018. http://hdl.handle.net/10803/663804.

Full text

Abstract:

Somatostatin (SST or SRIF14) is a peptidic hormone secreted throughout the central nervous system and in the gastrointestinal tract which has anti-secretory, anti-proliferative and anti-angiogenic effects. Although its administration as a drug is effective in certain conditions, its therapeutic use is limited by its short plasma half-life (< 3 min), the broad spectrum of biological responses and the lack of selectivity over its receptors (SSTRs). In order to obtain more stable and selective analogues we have incorporated both non-natural electron-rich and electron-poor aromatic amino acids at

APA, Harvard, Vancouver, ISO, and other styles

8

Riaz, Muhammad Kashif. "Peptide functionalized drug delivery system for an efficient lung cancer therapy." HKBU Institutional Repository, 2019. https://repository.hkbu.edu.hk/etd_oa/609.

Full text

Abstract:

Lung cancer has a high incidence rate globally and the leading cause of cancer related mortalities. In 2018, lung cancer has been estimated to cause 1.76 million deaths worldwide (18.33% of total cancer mortalities). In Hong Kong lung cancer has been a leading cause of cancer related deaths, and in 2016 caused 3780 deaths (26.6% of total cancer mortalities). Non-small cell lung cancer (NSCLC) is the major (~85%) lung cancer type, and five-year survival rate for lung cancer has estimated to be 18%. Thus, an efficient lung cancer treatment with lesser adverse effects is need of the hour. In this

APA, Harvard, Vancouver, ISO, and other styles

9

KALAJA, ODETA. "Nanoparticles based delivery System of Flavonoids for Cancer Therapy." Doctoral thesis, Università degli Studi di Trieste, 2018. http://hdl.handle.net/11368/2917683.

Full text

Abstract:

Nowadays, cancer remains one of the major public health problem. Although chemotherapeutic drugs efficiently kill cancer cells, these cells can defend themselves from such toxic compounds with a process called cancer multidrug resistance (MDR). Because of unsatisfactory treatment scenario there has been growing interest in the health advantages of using plant-derived compounds for cancer prevention or in the treatment of chemo-resistant cells. Anthocyanidins are a group of pigments belonging to the family of flavonoids present in red-blue fruits and vegetables. Several studies demonstrated tha

APA, Harvard, Vancouver, ISO, and other styles

10

Cheng, Yu. "Gold Nanoparticles as Drug Delivery Vectors for Photodynamic Therapy of Cancers." Case Western Reserve University School of Graduate Studies / OhioLINK, 2011. http://rave.ohiolink.edu/etdc/view?acc_num=case1301503263.

Full text

APA, Harvard, Vancouver, ISO, and other styles

11

Yin, Hongran. "RNA nanoparticles for anti-oncogenic miRNA and drug delivery for cancer therapy." The Ohio State University, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=osu1589836157141191.

Full text

APA, Harvard, Vancouver, ISO, and other styles

12

Madadi, Ardekani Sara. "CARBON NANOMATERIALS DERIVED FROM ORGANIC SOURCES FOR DRUG DELIVERY AND THERAPY." Thesis, The University of Sydney, 2019. http://hdl.handle.net/2123/20998.

Full text

Abstract:

Remotely triggered drug delivery using nanoparticles is an area of great interest for targeted therapy to fight cancer. We developed photoresponsive nanoparticles to remotely initiate the release of doxorubicin (DOX) to 3D cultured human breast cancer cells (MCF-7) via NIR two-photon excitation (TPE) using carbon nanomaterials (CNMs). The drug loading capacity of CND-P was measured to be 0.98 w/w with the ability to release DOX via two-photon excitation (TPE). The biocompatible CNMs showed 88% cell viability at concentrations as high as 1100 μg/mL. The combined chemo and photothermal therapeut

APA, Harvard, Vancouver, ISO, and other styles

13

Heister, Elena. "Functionalized carbon nanotubes as a multimodal drug delivery system for target cancer therapy." Thesis, University of Surrey, 2010. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.529424.

Full text

APA, Harvard, Vancouver, ISO, and other styles

14

Guo, Sijin. "RNA Nanoparticle as A Safe and Effective Drug Delivery Platform for Cancer Therapy." The Ohio State University, 2019. http://rave.ohiolink.edu/etdc/view?acc_num=osu1561719043509709.

Full text

APA, Harvard, Vancouver, ISO, and other styles

15

Stolzoff, Michelle L. "Designing the surface properties of expansile nanoparticles for targeted cancer therapy." Thesis, Boston University, 2013. https://hdl.handle.net/2144/21256.

Full text

Abstract:

Thesis (M.Sc.Eng.) PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you.<br>Nanoparticle-based drug delivery has been explored to circumvent the often-toxic chemotherapy treatments used today by providing a more efficient and specific delivery to diseased tissues. Recently we have developed polymeric

APA, Harvard, Vancouver, ISO, and other styles

16

García, Díaz María. "Drug delivery in photodynamic therapy: From pharmaceutics to animal testing." Doctoral thesis, Universitat Ramon Llull, 2012. http://hdl.handle.net/10803/81987.

Full text

Abstract:

S'ha estudiat el desenvolupament de fotosensibilitzadors i la seva formulació en teràpia fotodinàmica. S'han caracteritzat les propietats fotofísiques dels fotosensibilitzadors porficènics. S'han proposat diferents estratègies tals com la introducció de grups carboxilat en la perifèria o ions de metalls pesants en el nucli, per millorar el disseny de nous fotosensibilitzadors basats en el macrocicle porficènic. Entre ells, el temocè (m-THPPo), el porficè anàleg a la temoporfina, mostra excel•lents propietats fotofísiques, fotoestabilitat i alta eficàcia fotodinàmica. A causa de la seva alta

APA, Harvard, Vancouver, ISO, and other styles

17

Adjei, Isaac Morris. "Nanoparticle-mediated cancer therapy for primary and metastasized tumors." Case Western Reserve University School of Graduate Studies / OhioLINK, 2014. http://rave.ohiolink.edu/etdc/view?acc_num=case1386342707.

Full text

APA, Harvard, Vancouver, ISO, and other styles

18

Gade, Terence Peter Ferrante. "Integrated imaging of drug delivery : a molecular imaging approach to the optimization of cancer therapy /." Access full-text from WCMC:, 2007. http://proquest.umi.com/pqdweb?did=1432803381&sid=12&Fmt=2&clientId=8424&RQT=309&VName=PQD.

Full text

APA, Harvard, Vancouver, ISO, and other styles

19

Gubbins, James. "Engineering theranostic liposomes for image guided drug delivery as a novel nanomedicine for cancer therapy." Thesis, University of Manchester, 2016. https://www.research.manchester.ac.uk/portal/en/theses/engineering-theranostic-liposomes-forimage-guided-drug-delivery-as-a-novelnanomedicine-for-cancer-therapy(ce8381bb-84ee-4b9a-a96c-d09b21956c73).html.

Full text

Abstract:

Cancer mortality is progression-dependent thus its treatment relies on effective therapy and monitoring of responses. Nanoparticles have long been used to improve the therapeutic index of drugs by facilitating their transit to the target site at higher concentrations than free drugs, whilst protecting healthy tissues from an often potent and cytotoxic payload. Through the EPR (enhanced permeability and retention) effect, injected, PEGylated nanoparticles preferentially accumulate in tumour tissue deeming them eminently suitable for cancer intervention for delivery of both therapeutic and contr

APA, Harvard, Vancouver, ISO, and other styles

20

Yu, Bo. "Oligonucleotide Based Liposomal Nanoparticles for Leukemia and Liver Cancer Therapy." The Ohio State University, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=osu1275490450.

Full text

APA, Harvard, Vancouver, ISO, and other styles

21

Shao, Huimin. "Development of an advanced drug delivery system to prevent and treat breast cancer bone metastasis." Thesis, The University of Sydney, 2021. https://hdl.handle.net/2123/28640.

Full text

Abstract:

Metastastic breast cancer is one of the leading causes of cancer death among women worldwide. Bone metastases occur most frequently among breast cancer patients that significantly influence the patients’ quality of life and reduce their survival rate. Among all types of breast cancer, triple negative breast cancer (TNBC) is more aggressive and more likely to develop metastasis. Thus, a targeted preventative modality is highly demanded for this unmet challenge. Nanoparticles have been under investigation for a few decades and have shown ample potential for the treatment of challenging types of

APA, Harvard, Vancouver, ISO, and other styles

22

Erebor, Joan Onyebuchi. "Synthesis and evaluation of targeted dendrisomes as novel gene and drug delivery systems for cancer therapy." Thesis, University of Strathclyde, 2018. http://digitool.lib.strath.ac.uk:80/R/?func=dbin-jump-full&object_id=30187.

Full text

APA, Harvard, Vancouver, ISO, and other styles

23

Giesen, Beatriz [Verfasser], and Ulf Dietrich [Gutachter] Kahlert. "Gold Nanoparticles as Drug Delivery Systems for Brain Cancer Therapy / Beatriz Giesen ; Gutachter: Ulf Dietrich Kahlert." Düsseldorf : Universitäts- und Landesbibliothek der Heinrich-Heine-Universität Düsseldorf, 2021. http://d-nb.info/1237883814/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

24

Traore, Mahama Aziz. "Bacteria-Enabled Autonomous Drug Delivery Systems: Design, Modeling, and Characterization of Transport and Sensing." Diss., Virginia Tech, 2014. http://hdl.handle.net/10919/64326.

Full text

Abstract:

The lack of efficacy of existing chemotherapeutic treatments of solid tumors is partially attributed to the limited diffusion distance of therapeutics and the low selectivity of anti-cancer drugs with respect to cancerous tissue, which also leads to high levels of systemic toxicity in patients. Thus, chemotherapy can be enhanced through improving anti-cancer drug carrier selectivity and transport properties. Several strains of gram positive (e.g. Clostridium and Bifidobacterium) and gram-negative (e.g. Salmonella Typhimurium and Escherichia coli) bacteria have been shown to possess the innate

APA, Harvard, Vancouver, ISO, and other styles

25

Dalela, Manu. "Synthesis, characterization and biological evaluation of poly(styreneco-maleic anhydride) as a drug delivery vehicle for cancer therapy." Thesis, IIT Delhi, 2016. http://localhost:8080/xmlui/handle/12345678/7037.

Full text

APA, Harvard, Vancouver, ISO, and other styles

26

BABANYINAH, GODWIN KWEKU. "Theranostic Nanoparticles Folic acid-Carbon Dots-Drug(s) for Cancer." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/asrf/2021/presentations/40.

Full text

Abstract:

The main aim of this study is to synthesize theranostic nanoparticles (NPs) that will drastically increase the diagnostics and therapeutic efficacy for cancer. In this research, we had prepared the NPs which constitute carbon dots (CDs), the imaging agent, Folic acid, the targeting agent, and Doxorubicin (DOX) or Gemcitabine (GEM) as the chemotherapy agents. The prepared NPs include noncovalent FA-CDs-DOX, covalent CDs-FA-DOX, and covalent FA-CDs-GEM. The spectroscopy, ultraviolet-visible spectroscopy (UV-vis), fluorescence spectroscopy, and Fourier transform-infrared spectroscopy (FT-IR), wer

APA, Harvard, Vancouver, ISO, and other styles

27

Babanyinah, Godwin Kweku. "Theranostic Nanoparticles Folic Acid-Carbon Dots-Drug(s) for Cancer." Digital Commons @ East Tennessee State University, 2021. https://dc.etsu.edu/etd/3892.

Full text

Abstract:

This study aims to prepare theranostic nanoparticles (NPs) that are expected to increase cancer diagnostics and therapeutic efficacy. We prepared the NPs constituting carbon dots (CDs) as an imaging agent, folic acid as a targeting agent, doxorubicin (DOX), or gemcitabine (GEM) as chemotherapy agents. The NPs include noncovalent FA-CDs-DOX, covalent CDs-FA-DOX, and covalent FA-CDs-GEM. Through ultraviolet-visible spectroscopy, fluorescence spectroscopy, and Fourier transform-infrared spectroscopy, the fabrication of these NPs was confirmed. It was discovered that the high drug loading efficien

APA, Harvard, Vancouver, ISO, and other styles

28

Farvadi, F., A. M. Tamaddon, and F. Hashemi. "PEG-grafted Hyperbranched Polyethyleneimine-Oxidized Single Walled Carbon Nanotube Complex (PEG-PEI-SWNT) for Sustained Delivery of Doxorubicin." Thesis, Sumy State University, 2012. http://essuir.sumdu.edu.ua/handle/123456789/34928.

Full text

Abstract:

To take advantages of single-walled carbon nanotubes (SWNTs) for cellular delivery of chemotherapeutic agents (e.g. doxorubicin) in order to decrease doxorubicin toxicity and increase its efficacy, we aimed to develop a novel approach to aqueous disperse and stabilize SWNTs through consequent steps of oxidation (oxSWNT) and PEG-PEI complexation (PEG-PEI-SWNT). Doxorubicin was loaded onto the modified SWNTs in alkalione pH with more considerable capacity ( 900 %) than those previously reported, due to complex formation with PEI proved by UV-visible spectroscopy. The loaded carrier was stab

APA, Harvard, Vancouver, ISO, and other styles

29

Martínez, Edo Gabriel. "Radial-capped mesoporous silica nanoparticles for multiple drug delivery." Doctoral thesis, Universitat Ramon Llull, 2020. http://hdl.handle.net/10803/669168.

Full text

Abstract:

En la present tesi doctoral, s'ha desenvolupat un sistema d'alliberament de fàrmacs sensible a pH basat en nanopartícules mesoporoses de sílice (MSN). Els porus de la nanopartícula estan radialment obstruïts mitjançant la funcionalització de cadenes de PEG, substituïdes amb un fàrmac en un dels seus extrems. L'objectiu d'aquesta nova metodologia és la de preservar la càrrega interna d'aquestes MSN. En primer lloc, s'ha estudiat el concepte d'obstrucció radial per avaluar la utilitat pràctica d'aquest mètode. Per aquesta raó, diferents tipus de cadenes de PEG amb càrrega, a saber, amines quate

APA, Harvard, Vancouver, ISO, and other styles

30

Guerrant, William. "Targeted histone deacetylase inhibition." Diss., Georgia Institute of Technology, 2012. http://hdl.handle.net/1853/44907.

Full text

Abstract:

Histone deacetylase (HDAC) inhibitors (HDACi) have demonstrated a wealth of biological effects, including anti-proliferative, anti-inflammatory, anti-parasitic, and cognition-enhancing activities. The recent FDA approvals of the inhibitors SAHA and FK-228 have validated HDACi clinical use in cutaneous T cell lymphoma, while numerous clinical trials are currently ongoing using HDACi against a variety of disease states. While the future of the HDAC field looks increasingly promising, there are lingering issues hindering broader use. Recent data point to dysregulation of specific HDAC isoforms in

APA, Harvard, Vancouver, ISO, and other styles

31

Nadal, Bufi Ferran. "Peptide-based drugs to inhibit LDH5, a potential target for cancer therapy." Thesis, Queensland University of Technology, 2022. https://eprints.qut.edu.au/232526/1/Ferran_Nadal%20Bufi_Thesis.pdf.

Full text

Abstract:

This thesis investigates novel strategies to target lactate dehydrogenase 5 (LDH5), a protein involved in cancer. After decades of research without success, this thesis reports the development of the first molecules able to inhibit the activity of LDH5 with an alternative mechanism of action: disrupting its structure. To do that, an emerging class of drugs called peptides are explored. The lead peptide of this work successfully kills breast cancer cells via LDH5 inhibition. The validation of this strategy is relevant because it can be applied to many other cancer targets that have been traditi

APA, Harvard, Vancouver, ISO, and other styles

32

Schilb, Andrew L. "OPTIMIZATION OF NON-VIRAL GENE DELIVERY SYSTEM FOR IMAGE-GUIDED THERAPY FOR TRIPLE NEGATIVE BREAST CANCER." Case Western Reserve University School of Graduate Studies / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=case1627484657204883.

Full text

APA, Harvard, Vancouver, ISO, and other styles

33

Foy, Susan Patricia. "Multifunctional Magnetic Nanoparticles for Cancer Imaging and Therapy." Case Western Reserve University School of Graduate Studies / OhioLINK, 2012. http://rave.ohiolink.edu/etdc/view?acc_num=case1319836040.

Full text

APA, Harvard, Vancouver, ISO, and other styles

34

Peralta, Donna V. "Synthesis and Applications of Mutimodal Hybrid Albumin Nanoparticles for Chemotherapeutic Drug Delivery and Phototherml Therapy Platforms." ScholarWorks@UNO, 2014. http://scholarworks.uno.edu/td/1886.

Full text

Abstract:

Progress has been made in using human serum albumin nanoparticles (HSAPs) as carrier systems for targeted treatment of cancer. Human serum albumin (HSA), the most abundant human blood protein, can form HSAPs via a desolvation and crosslinking method, with the size of the HSAPs having crucial importance for drug loading and in vivo performance. Gold nanoparticles have also gained medicinal attention due to their ability to absorb near-infrared (NIR) light. These relatively non-toxic particles offer combinational therapy via imaging and photothermal therapy (PPTT) capabilities. A desolvation and

APA, Harvard, Vancouver, ISO, and other styles

35

Lahori, Deeksha. "Combination of nitric oxide and polymer based drug delivery system to improve the effectiveness of a peptide inhibitor in cancer therapy outcomes." Thesis, University of Sydney, 2020. https://hdl.handle.net/2123/24311.

Full text

Abstract:

The recent development in the field of nanotechnology offers the opportunity to alter the pharmacokinetic profiles of drugs, reducing off-target toxicity and improving therapeutic index, and ultimately patient outcome. This study aims to use a biodegradable and biocompatible material which is a modified form of the glucose polymer ‘dextran’. Aldehyde-functionalised dextran is the oxidised form of dextran to introduce aldehyde functionality for stably chemical loading therapeutic agents for its potential application in cancer treatment. Cancer is a heterogeneous disease caused by the progressiv

APA, Harvard, Vancouver, ISO, and other styles

36

VERDERIO, PAOLO. "Synthesis and Biofunctionalization of Novel Composite Nanocarriers for Targeted Detection and Treatment of Malignant Cells." Doctoral thesis, Università degli Studi di Milano-Bicocca, 2014. http://hdl.handle.net/10281/50789.

Full text

Abstract:

At present, mammary carcinoma is the second most common type of malignant tumor in adult women after lung cancer, as more than one million women are diagnosed with breast cancer every year. Despite advances in diagnosis and treatment, which have resulted in a decrease in mortality in this decade, breast cancer remains a major public health problem. Nevertheless, the heterogeneity of human breast cancer in terms of genetic features, molecular profiles and clinical behavior represents a constraint obstructing the discovery of a solution to the disease. It is currently considered that the chances

APA, Harvard, Vancouver, ISO, and other styles

37

Holden, Christopher A. "MODIFIED PAMAM DENDRIMERS IN TUNABLE DRUG-DELIVERY SYSTEMS: A SUSTAINED-RELEASE DENDRIMER HYDROGEL FOR ANTI-GLAUCOMA DRUGS AND SURFACE-ENGINEERED MACROPHAGES AS NANOPARTICLE CARRIERS FOR TARGETED ANTI-CANCER THERAPY." VCU Scholars Compass, 2017. http://scholarscompass.vcu.edu/etd/5038.

Full text

Abstract:

Two specific drug-delivery applications were sought in this work using polyamidoamine (PAMAM) dendrimers. One drug-delivery system used a novel dendrimer hydrogel (DH) for sustained delivery of anti-glaucoma drugs. In this work, PAMAM G3.0 dendrimers were covalently bonded with poly(ethylene glycol) (PEG12000) molecules which were subsequently acrylated, resulting in photocurable DH conjugates. For pharmacological studies, DH were loaded with a solution of intraocular pressure lowering drugs, brimonidine and timolol maleate, and were characterized for in vitro release and ex vivo transport an

APA, Harvard, Vancouver, ISO, and other styles

38

Hervault, A. M. M. "Development of a doxorubicin-loaded dual pH- and thermo-responsive magnetic nanocarrier for application in magnetic hyperthermia and drug delivery in cancer therapy." Thesis, University College London (University of London), 2017. http://discovery.ucl.ac.uk/1566981/.

Full text

Abstract:

Magnetic nanocarriers have attracted increasing attention for multimodal cancer therapy due to the possibility to deliver heat and drugs locally. The enhancement of the anti-cancer effect of chemotherapy with application of concurrent hyperthermia has been noticed more than thirty years ago. However, combining magnetic nanoparticles with drug molecules in the same nanoformulation has only recently emerged as a promising tool for the simultaneous application of hyperthermia and chemotherapy. In this work, initial experimentation was primarily focused on the synthesis of magnetic nanoparticles o

APA, Harvard, Vancouver, ISO, and other styles

39

Mott, Landon Alexander. "TOWARDS THE RATIONAL DESIGN AND APPLICATION OF POLYMERS FOR GENE THERAPY: INTERNALIZATION AND INTRACELLULAR FATE." UKnowledge, 2019. https://uknowledge.uky.edu/cme_etds/99.

Full text

Abstract:

Gene therapy is an approach for the treatment of acquired cancers, infectious disease, degenerative disease, and inherited genetic indications. Developments in the fields of immunotherapies and CRISPR/Cas9 genome editing are revitalizing the efforts to move gene therapy to the forefront of modern medicine. However, slow progress and poor clinical outcomes have plagued the field due to regulatory and safety concerns associated with the flagship delivery vector, the recombinant virus. Immunogenicity and poor transduction in certain cell types severely limits the utility of viruses as a delivery

APA, Harvard, Vancouver, ISO, and other styles

40

Wei, Tuo. "Systèmes innovants de délivrance de médicaments basés sur des nanomicelles pour le traitement du cancer." Thesis, Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4031.

Full text

Abstract:

Une faible biodisponibilité et une haute toxicité des médicaments anticancéreux, ajoutées à une résistance aux médicaments, constituent des obstacles majeurs pour le traitement du cancer. L'application des nanotechnologies pour la délivrance de médicaments est largement pressentie pour aborder ces problèmes. Premièrement, nous avons utilisé un peptide CRGDK comme ligand spécifique pour les cellules cancéreuses que nous avons conjugué au DSPE-PEG2000 pour préparer les nanomicelles encapsulant le médicament anticancéreux doxorubicine. Le peptide CRGDK conjugué aux nanomicelles provoque la liaiso

APA, Harvard, Vancouver, ISO, and other styles

41

Bon, Romero Ignacio. "Development and characterization of a new hydrogel for endoscopic resection. Efficacy as a drug-delivery platform for local therapy in colorectal cancer and experimental colitis animal models." Doctoral thesis, Universitat Autònoma de Barcelona, 2019. http://hdl.handle.net/10803/667190.

Full text

Abstract:

L'endoscòpia és un procediment mínimament invasiu que permet diagnosticar condicions dins del tracte gastrointestinal, respiratori o urinari, mitjançant un endoscopi que s'insereix a través d'un orifici corporal. Els avenços en la medicina endoscòpica han conduït al desenvolupament d'una endoscòpia terapèutica que permet als metges tractar nombroses condicions mitjançant tècniques endoscòpiques com l'eliminació de pòlips i tumors primerencs. La resecció endoscòpica de lesions grans condueix a defectes extensius de la mucosa i exposició submucosa, amb un risc substancial de complicacions

APA, Harvard, Vancouver, ISO, and other styles

42

Wei, Tuo. "Systèmes innovants de délivrance de médicaments basés sur des nanomicelles pour le traitement du cancer." Electronic Thesis or Diss., Aix-Marseille, 2015. http://www.theses.fr/2015AIXM4031.

Full text

Abstract:

Une faible biodisponibilité et une haute toxicité des médicaments anticancéreux, ajoutées à une résistance aux médicaments, constituent des obstacles majeurs pour le traitement du cancer. L'application des nanotechnologies pour la délivrance de médicaments est largement pressentie pour aborder ces problèmes. Premièrement, nous avons utilisé un peptide CRGDK comme ligand spécifique pour les cellules cancéreuses que nous avons conjugué au DSPE-PEG2000 pour préparer les nanomicelles encapsulant le médicament anticancéreux doxorubicine. Le peptide CRGDK conjugué aux nanomicelles provoque la liaiso

APA, Harvard, Vancouver, ISO, and other styles

43

Croissant, Jonas. "NANOMÉDECINE THÉRANOSTIQUE ACTIVÉE À DEUX-PHOTONS POUR LE TRAITEMENT DU CANCER." Thesis, Montpellier, Ecole nationale supérieure de chimie, 2014. http://www.theses.fr/2014ENCM0004/document.

Full text

Abstract:

La nanomédecine activée à deux-photon est devenue l'un des principaux candidats à l'accomplissement de la sélectivité spatiotemporelle nécessaire pour la nanomédecine. En effet, la raison d'être de l'application médicale de nanotechnologie dans le domaine du traitement du cancer est de diminuer et supprimer les effets secondaires causés par les techniques actuelles telles que la chimiothérapie et la radiothérapie, à cause de leur manque de sélectivité. Parmi diverses nanoparticules (NPs), les nanoparticules de silice mésoporeuse (MSN) ont attiré une attention croissante dans la dernière décenn

APA, Harvard, Vancouver, ISO, and other styles

44

Champeau, Mathilde. "Dissolving microneedles for an optimal transdermal delivery of an active principle used in photodynamic therapy : development and proof of concept." Thesis, Lille 2, 2020. http://www.theses.fr/2020LIL2S007.

Full text

Abstract:

Les cancers de la peau de type non mélanome constituent un enjeu sanitaire majeur : l’OMS en dénombre 2 à 3 millions par an. Pour les traiter, il faut parfois recourir à une résection chirurgicale localisée. Pour éviter ce geste, la thérapie photodynamique (PDT) est un traitement alternatif intéressant. Actuellement utilisée en clinique, la PDT consiste à appliquer sur la peau lésée une crème contenant un précurseur photosensible qui après métabolisation et sous excitation lumineuse induit la mort cellulaire. Néanmoins, cette technique atteint ses limites thérapeutiques lorsque la crème ne pén

APA, Harvard, Vancouver, ISO, and other styles

45

Blaudszun, André-René [Verfasser], and Gerhard [Akademischer Betreuer] Wenz. "Ex vivo activated human T lymphocytes as living drug delivery vehicles for cancer therapy : in vitro studies with nanoparticulate idarubicin and complexed mTHPP as payload / André-René Blaudszun. Betreuer: Gerhard Wenz." Saarbrücken : Saarländische Universitäts- und Landesbibliothek, 2016. http://d-nb.info/1100061568/34.

Full text

APA, Harvard, Vancouver, ISO, and other styles

46

Thomas, Sean Casey. "A Developed and Characterized Orthotopic Rat Glioblastoma Multiforme Model." Thesis, Virginia Tech, 2020. http://hdl.handle.net/10919/100772.

Full text

Abstract:

This thesis project serves to fill experimental gaps needed to advance the goal of performing pre-clinical trials using an orthotopic rat glioblastoma model to evaluate the efficacy of high-frequency electroporation (H-FIRE) and QUAD-CTX tumor receptor-targeted cytotoxic conjugate therapies, individually and in combination, in selectively and thoroughly treating glioblastoma multiforme. In order to achieve this, an appropriate model must be developed and characterized. I have transduced F98 rat glioma cells to express red-shifted firefly luciferase, which will facilitate longitudinal tumor mon

APA, Harvard, Vancouver, ISO, and other styles

47

Babatunde, Oluwaseun Oyeniyi. "Exploring the potential of Rhodobacter sphaeroides in photodynamic therapy of tumors." Bowling Green State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1624793446693196.

Full text

APA, Harvard, Vancouver, ISO, and other styles

48

Babatunde, Oluwaseun Oyeniyi. "Exploring the potential of Rhodobacter sphaeroides in photodynamic therapy of tumors." Bowling Green State University / OhioLINK, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=bgsu1624793446693196.

Full text

APA, Harvard, Vancouver, ISO, and other styles

49

Bretin, Ludovic. "Thérapie photodynamique (PDT) dans un modèle in vitro et in vivo de cancer colorectal : utilisation d'un photosensibilisateur nanovectorisé." Thesis, Limoges, 2019. http://www.theses.fr/2019LIMO0052/document.

Full text

Abstract:

Le cancer colorectal (CCR) est l’un des cancers les plus diagnostiqués dans le monde mais surtout le 2ème cancerle plus mortel. Malgré les progrès de la recherche médicale dans les traitements anticancéreux, de nombreux effetssecondaires subsistent chez les patients ainsi que l’apparition de résistances aux traitements conventionnels. Ledéveloppement de nouvelles stratégies thérapeutiques anticancéreuses est donc nécessaire afin d’améliorer la priseen charge de ces patients. La thérapie photodynamique (PDT) utilisant des photosensibilisateurs (PS) se présentecomme une stratégie thérapeutique i

APA, Harvard, Vancouver, ISO, and other styles

50

Liu, Juan. "Nouveaux systèmes nanométriques et ph dépendant pour le transport de médicaments contre les phénomènes de résistances." Thesis, Aix-Marseille, 2016. http://www.theses.fr/2016AIXM4072.

Full text

Abstract:

La résistance aux médicaments constitue un obstacle majeur pour le traitement du cancer. Les systèmes nanoparticulaires de délivrance de médicaments (nanoparticule drug delivery system, NDDS) sont pressentis pour apporter un nouvel espoir dans le traitement du cancer afin de surmonter la résistance aux médicaments en délivrant spécifiquement l’agent anticancéreux dans la lésion tumorale par effet EPR. Cela aura pour effet d’augmenter la concentration locale en médicaments et par conséquent d’améliorer l'efficacité thérapeutique tout en épargnant les tissus sains afin d'éviter les effets second

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!