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Journal articles on the topic 'Drug delivery in cancer therapy'

Author: Grafiati

Published: 6 September 2023

Last updated: 31 July 2025

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1

SL, Prabu. "Nano based Drug Delivery System for Cancer Therapy: A Next Generation Theranostics." Bioequivalence & Bioavailability International Journal 6, no. 2 (2022): 1–17. http://dx.doi.org/10.23880/beba-16000178.

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Cancer is considered as one of the foremost cause of illness and death with very complex pathophysiology even though prominent advancement has been made on innovative tumor treatments. Therapeutic properties and the global survival rate are still disappointing for the patients with cancer. There is a shortfall in the capabilities of these cancer therapies, some novel strategies are developed to provide better treatment therapies to improve their quality of life and also aids in reducing the number of deaths. Amongst the cardinal phases towards ensuring ideal cancer management is early diagnosi

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Yadav, Neena, Arul Prakash Francis, Veeraraghavan Vishnu Priya, et al. "Polysaccharide-Drug Conjugates: A Tool for Enhanced Cancer Therapy." Polymers 14, no. 5 (2022): 950. http://dx.doi.org/10.3390/polym14050950.

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Cancer is one of the most widespread deadly diseases, following cardiovascular disease, worldwide. Chemotherapy is widely used in combination with surgery, hormone and radiation therapy to treat various cancers. However, chemotherapeutic drugs can cause severe side effects due to non-specific targeting, poor bioavailability, low therapeutic indices, and high dose requirements. Several drug carriers successfully overcome these issues and deliver drugs to the desired sites, reducing the side effects. Among various drug delivery systems, polysaccharide-based carriers that target only the cancer c

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Subhan, Md Abdus, and Vladimir P. Torchilin. "Advances in Targeted Therapy of Breast Cancer with Antibody-Drug Conjugate." Pharmaceutics 15, no. 4 (2023): 1242. http://dx.doi.org/10.3390/pharmaceutics15041242.

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Antibody–drug conjugates (ADCs) are a potential and promising therapy for a wide variety of cancers, including breast cancer. ADC-based drugs represent a rapidly growing field of breast cancer therapy. Various ADC drug therapies have progressed over the past decade and have generated diverse opportunities for designing of state-of-the-art ADCs. Clinical progress with ADCs for the targeted therapy of breast cancer have shown promise. Off-target toxicities and drug resistance to ADC-based therapy have hampered effective therapy development due to the intracellular mechanism of action and limited

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Anitha, P., J. Bhargavi, G. Sravani, B. Aruna, and Ramkanth S. "RECENT PROGRESS OF DENDRIMERS IN DRUG DELIVERY FOR CANCER THERAPY." International Journal of Applied Pharmaceutics 10, no. 5 (2018): 34. http://dx.doi.org/10.22159/ijap.2018v10i5.27075.

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With the recent advances of nanotechnology, dendrimers are emerging as a highly attractive class of drug delivery vectors for cancer therapy. Dendrimers are multifunctional smart Nanocarriers to deliver one or more therapeutic agent safely and selectively to cancer cells. The high level of control over the synthesis of dendritic architecture makes dendrimers a nearly perfect (spherical) nanocarrier for site-specific drug delivery. The presence of functional groups in the dendrimers exterior also permits the addition of other moieties that can actively target certain diseases which are now wide

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Vasir, Jaspreet K., and Vinod Labhasetwar. "Targeted Drug Delivery in Cancer Therapy." Technology in Cancer Research & Treatment 4, no. 4 (2005): 363–74. http://dx.doi.org/10.1177/153303460500400405.

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Chemotherapy has been the main modality of treatment for cancer patients; however, its success rate remains low, primarily due to limited accessibility of drugs to the tumor tissue, their intolerable toxicity, development of multi-drug resistance, and the dynamic heterogeneous biology of the growing tumors. Better understanding of tumor biology in recent years and new targeted drug delivery approaches that are being explored using different nanosystems and bioconjugates provide optimism in developing successful cancer therapy. This article reviews the possibilities and challenges for targeted

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P, Mohmed Fauzith, Balaji T, Bala Krishnan P, and John Felix S.N. "Nanotechnology-Future Prospects of Sperm-Driven Therapy in Oncology - A Review Article." International Journal of Health Sciences and Research 15, no. 2 (2025): 100–105. https://doi.org/10.52403/ijhsr.20250212.

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Cancer is a major fatal disease worldwide, with millions of new cases and deaths each year. While treatments like chemotherapy and immunotherapy have saved many lives, they often come with severe side effects. A better solution being developed targeted drug delivery, which aims to deliver medication directly to cancer cells, which increasing the effectiveness of the treatment and reducing harmful side effects. One fascinating approach under development is sperm-loaded nanotherapy. This innovative method uses sperm cells as natural carriers for cancer drugs. Because sperm can move efficiently t

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., Sebastine, and Mohamed Zerein Fathima. "Nanosuspensions in Breast Cancer Therapy: A Comprehensive Overview." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 02 (2024): 1090–98. http://dx.doi.org/10.25258/ijddt.14.2.73.

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Nanosuspensions offer a promising avenue for enhancing breast cancer treatment through improved drug delivery, solubility, and targeting. These colloidal dispersions contain submicron drug particles, significantly increasing surface area and enhancing drug solubility and dissolution rates. This improvement can lead to increased drug bioavailability, enabling lower doses and reduced side effects. It is also possible to engineer nanosuspensions so that they are controlled-release drugs, providing sustained therapeutic levels at the tumor site. Nanosuspensions facilitate targeted drug delivery, w

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Singh, Amit. "Advancements in Nanotechnology: Revolutionizing Drug Delivery Systems for Precision Targeted Cancer Therapy." Journal of Scientific Advances 1, no. 1 (2024): 23–33. https://doi.org/10.63665/jsa.v1i1.01.

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Nanotechnology has emerged as a transformative approach in medicine, particularly in the field of targeted cancer therapy. This paper explores advancements in nanotechnology that have significantly improved drug delivery systems, allowing for more precise targeting of cancer cells while minimizing the side effects typically associated with traditional chemotherapy. The study highlights various nanocarrier systems, including liposomes, nanoparticles, and dendrimers, discussing their mechanisms of action, advantages, and potential challenges in clinical applications. The findings suggest that na

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Montané, Xavier, Anna Bajek, Krzysztof Roszkowski, et al. "Encapsulation for Cancer Therapy." Molecules 25, no. 7 (2020): 1605. http://dx.doi.org/10.3390/molecules25071605.

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The current rapid advancement of numerous nanotechnology tools is being employed in treatment of many terminal diseases such as cancer. Nanocapsules (NCs) containing an anti-cancer drug offer a very promising alternative to conventional treatments, mostly due to their targeted delivery and precise action, and thereby they can be used in distinct applications: as biosensors or in medical imaging, allowing for cancer detection as well as agents/carriers in targeted drug delivery. The possibility of using different systems—inorganic nanoparticles, dendrimers, proteins, polymeric micelles, liposom

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Yu, Han, Na Ning, Xi Meng, Chuda Chittasupho, Lingling Jiang, and Yunqi Zhao. "Sequential Drug Delivery in Targeted Cancer Therapy." Pharmaceutics 14, no. 3 (2022): 573. http://dx.doi.org/10.3390/pharmaceutics14030573.

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Cancer is a major public health problem and one of the leading causes of death. However, traditional cancer therapy may damage normal cells and cause side effects. Many targeted drug delivery platforms have been developed to overcome the limitations of the free form of therapeutics and biological barriers. The commonly used cancer cell surface targets are CD44, matrix metalloproteinase-2, folate receptors, etc. Once the drug enters the cell, active delivery of the drug molecule to its final destination is still preferred. The subcellular targeting strategies include using glucocorticoid recept

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Sayyed, Adil A., Piyush Gondaliya, Palak Bhat, et al. "Role of miRNAs in Cancer Diagnostics and Therapy: A Recent Update." Current Pharmaceutical Design 28, no. 6 (2022): 471–87. http://dx.doi.org/10.2174/1381612827666211109113305.

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: The discovery of microRNAs (miRNAs) has been one of the revolutionary developments and has led to the advent of new diagnostic and therapeutic opportunities for the management of cancer. In this regard, miRNA dysregulation has been shown to play a critical role in various stages of tumorigenesis, including tumor invasion, metastasis as well as angiogenesis. Therefore, miRNA profiling can provide accurate fingerprints for the development of diagnostic and therapeutic platforms. This review discusses the recent discoveries of miRNA- based tools for early detection of cancer as well as disease

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Shakil, Md Salman, Kazi Mustafa Mahmud, Mohammad Sayem, et al. "Using Chitosan or Chitosan Derivatives in Cancer Therapy." Polysaccharides 2, no. 4 (2021): 795–816. http://dx.doi.org/10.3390/polysaccharides2040048.

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Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionall

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Li, Jiayao, Yinan Liu, and Hend Abdelhakim. "Drug Delivery Applications of Coaxial Electrospun Nanofibres in Cancer Therapy." Molecules 27, no. 6 (2022): 1803. http://dx.doi.org/10.3390/molecules27061803.

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Cancer is one of the most serious health problems and the second leading cause of death worldwide, and with an ageing and growing population, problems related to cancer will continue. In the battle against cancer, many therapies and anticancer drugs have been developed. Chemotherapy and relevant drugs are widely used in clinical practice; however, their applications are always accompanied by severe side effects. In recent years, the drug delivery system has been improved by nanotechnology to reduce the adverse effects of the delivered drugs. Among the different candidates, core–sheath nanofibr

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Sahajwani, Ritika, Manish Srivastava, Anamika Srivastava, et al. "Advanced Materials in Cancer Therapy." Green Chemistry & Technology Letters 7, no. 2 (2021): 01–17. http://dx.doi.org/10.18510/gctl.2021.721.

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The overview of this review article depends on the various techniques of formation of silver nanoparticles and different application take place in medicinal point of view. The branch of nanotechnology plays an important role in medical science research. In this different nanoparticle is synthesized which have various application in gene delivery, drug delivery and reduce the toxic effect of drugs in the human body and also act as an antibacterial in pharmaceutical industries. In recent days silver nanoparticles have had an important role due to their optical and catalytic propertie

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Zhao, Xiangcheng, Nuli Xie, Hailong Zhang, Wenhu Zhou, and Jinsong Ding. "Bacterial Drug Delivery Systems for Cancer Therapy: “Why” and “How”." Pharmaceutics 15, no. 9 (2023): 2214. http://dx.doi.org/10.3390/pharmaceutics15092214.

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Cancer is one of the major diseases that endanger human health. However, the use of anticancer drugs is accompanied by a series of side effects. Suitable drug delivery systems can reduce the toxic side effects of drugs and enhance the bioavailability of drugs, among which targeted drug delivery systems are the main development direction of anticancer drug delivery systems. Bacteria is a novel drug delivery system that has shown great potential in cancer therapy because of its tumor-targeting, oncolytic, and immunomodulatory properties. In this review, we systematically describe the reasons why

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Srivastava, Anand Narain, Jata Shankar Misra, Sharique Ahmad, and Subuhi Anwar. "ORAL CANCER: NOVEL TREATMENTS AND APPROACHES." Era's Journal of Medical Research 9, no. 2 (2022): 256–61. http://dx.doi.org/10.24041/ejmr2022.40.

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The aggressive tumour known as oral cancer can metastasize, produce a high fatality rate, and infect nearby tissue. Surgery, chemotherapy, and radiation therapy, for example, are common treatment options that, when used in clinical settings, have both minimal drawbacks and major side effects. Currently, oral therapeutic medication delivery using targeted drug administration is proving to be effective. In recent years, an effective alternative therapy known as “nanomedicine,” or using nanoplatforms to deliver drugs for the treatment of cancer, has evolved. Thanks to the use of nanoplatforms, dr

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Yang, Yaoyao, Rui Zhang, Zhiyuan Liang, et al. "Application of Electrospun Drug-Loaded Nanofibers in Cancer Therapy." Polymers 16, no. 4 (2024): 504. http://dx.doi.org/10.3390/polym16040504.

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In the 21st century, chemotherapy stands as a primary treatment method for prevalent diseases, yet drug resistance remains a pressing challenge. Utilizing electrospinning to support chemotherapy drugs offers sustained and controlled release methods in contrast to oral and implantable drug delivery modes, which enable localized treatment of distinct tumor types. Moreover, the core–sheath structure in electrospinning bears advantages in dual-drug loading: the core and sheath layers can carry different drugs, facilitating collaborative treatment to counter chemotherapy drug resistance. This appro

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18

Gupta, Chetna, Aadya Jaipuria, and Nikesh Gupta. "Inhalable Formulations to Treat Non-Small Cell Lung Cancer (NSCLC): Recent Therapies and Developments." Pharmaceutics 15, no. 1 (2022): 139. http://dx.doi.org/10.3390/pharmaceutics15010139.

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Cancer has been the leading cause of mortalities, with lung cancer contributing 18% to overall deaths. Non-small cell lung cancer (NSCLC) accounts for about 85% of all lung cancers. The primary form of therapy used to treat lung cancer still includes oral and systemic administration of drugs, radiotherapy, or chemotherapy. Some patients have to go through a regime of combination therapy. Despite being the only available form of therapy, their use is limited due to the adverse effects, toxicity, and development of resistance over prolonged use. This led to a shift and progressive evolution into

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Alfuraiji, Narjes, Weam Kadhim, Rana Hameed, and Qasim Chyad Abdulzahra. "Application of Nano-particulate drug delivery systems to deliver therapeutic agents into cancer cells." Karbala Journal of Medicine 14, no. 2 (2022): 2496–512. http://dx.doi.org/10.70863/karbalajm.v14i2.886.

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Cancer is a disorder in which a group of cells grows uncontrollably, disregarding the cell division's physiological rules. Since its discovery (although the word cancer was not used)3000 BC, extraordinary research aims to uncover novel treatment approaches for combating cancer. Currently, over 60% of all ongoing clinical trials worldwide focus on cancer. The selection of treatment depends on the type of cancer, site, and stage of progression. Surgery, radiation-based surgical knives, chemotherapy, and radiotherapy are traditional treatment approaches that are mostly used. Side effects associat

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Lewis, Lionel D. "Drug Delivery Systems in Cancer Therapy." British Journal of Clinical Pharmacology 58, no. 3 (2004): 336. http://dx.doi.org/10.1111/j.1365-2125.2004.02137.x.

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Puris, Elena, Gert Fricker, and Mikko Gynther. "The Role of Solute Carrier Transporters in Efficient Anticancer Drug Delivery and Therapy." Pharmaceutics 15, no. 2 (2023): 364. http://dx.doi.org/10.3390/pharmaceutics15020364.

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Transporter-mediated drug resistance is a major obstacle in anticancer drug delivery and a key reason for cancer drug therapy failure. Membrane solute carrier (SLC) transporters play a crucial role in the cellular uptake of drugs. The expression and function of the SLC transporters can be down-regulated in cancer cells, which limits the uptake of drugs into the tumor cells, resulting in the inefficiency of the drug therapy. In this review, we summarize the current understanding of low-SLC-transporter-expression-mediated drug resistance in different types of cancers. Recent advances in SLC-tran

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Cai, Lisha, Xiaoling Xu, and Wei Chen. "The Current State of the Art in PARP Inhibitor-Based Delivery Nanosystems." Pharmaceutics 14, no. 8 (2022): 1647. http://dx.doi.org/10.3390/pharmaceutics14081647.

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Poly (adenosine diphosphate [ADP]–ribose) polymerases inhibitors (PARPi), the first clinically approved drug that exhibits synthetic lethality, are moving to the forefront of cancer treatments. Currently, the oral bioavailability of PARPi is quite low; thus, it is a major challenge to effectively and safely deliver PARPi during clinical cancer therapy. Nanotechnology has greatly advanced the development of drug delivery. Based on the basic characteristics and various forms of nanoparticles, drug delivery systems can prolong the time that drugs circulate, realize the controlled release of drugs

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Hafeez, Umbreen, Sagun Parakh, Hui K. Gan, and Andrew M. Scott. "Antibody–Drug Conjugates for Cancer Therapy." Molecules 25, no. 20 (2020): 4764. http://dx.doi.org/10.3390/molecules25204764.

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Antibody–drug conjugates (ADCs) are novel drugs that exploit the specificity of a monoclonal antibody (mAb) to reach target antigens expressed on cancer cells for the delivery of a potent cytotoxic payload. ADCs provide a unique opportunity to deliver drugs to tumor cells while minimizing toxicity to normal tissue, achieving wider therapeutic windows and enhanced pharmacokinetic/pharmacodynamic properties. To date, nine ADCs have been approved by the FDA and more than 80 ADCs are under clinical development worldwide. In this paper, we provide an overview of the biology and chemistry of each co

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Pandya, Tosha, Kaushika Kaushika Patel, Rudree Pathak, and Shreeraj Shah. "Liposomal Formulations In Cancer Therapy: Passive Versus Active Targeting." Asian Journal of Pharmaceutical Research and Development 7, no. 2 (2019): 35–38. http://dx.doi.org/10.22270/ajprd.v7i2.489.

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In Cancer therapy, Nano drug delivery system comprising of Liposomes, are the most successful mode of treatment in present scenario which also has real time clinical application. Recently it is found that the closed bilayer phospholipid vesicles have many technical advantages over the initially used liposomal formulations. The delivery of therapeutics encapsulated in liposomes changes the biological distribution profile and improves the drug therapeutic indices of various drugs. This review article throws light onto many clinical liposomal drug delivery products. The liposome Nano drug deliver

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Song, Cheeun, Seung Ju Jang, Woo Hyeok Jeon, Sejung Maeng, Jong Hyun Tae, and In Ho Chang. "Nanomedicines for Therapy of Bladder Cancer." Korean Journal of Urological Oncology 20, no. 4 (2022): 235–47. http://dx.doi.org/10.22465/kjuo.2022.20.4.235.

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Bladder cancer is one of most common malignant urinary tract tumor types, and transurethral resection of nonmuscle invasive bladder cancer followed by intravesical instillation of immunochemotherapy is the standard treatment approach to minimize recurrence and delay progression of bladder cancer. In general, conventional intravesical immunochemotherapy lacks selectivity for tumor tissues and the effect of drug is reduced with the excretion of urine leading to frequent administration and bladder irritation symptoms. Recently, nanomedicines which adhere to the bladder tumors for a long time, and

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Iravani, Siavash, and Rajender S. Varma. "Alginate-Based Micro- and Nanosystems for Targeted Cancer Therapy." Marine Drugs 20, no. 10 (2022): 598. http://dx.doi.org/10.3390/md20100598.

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Alginates have been widely explored due to their salient advantages of hydrophilicity, biocompatibility, mucoadhesive features, bioavailability, environmentally-benign properties, and cost-effectiveness. They are applied for designing micro- and nanosystems for controlled and targeted drug delivery and cancer therapy as alginate biopolymers find usage in encapsulating anticancer drugs to improve their bioavailability, sustained release, pharmacokinetics, and bio-clearance. Notably, these nanomaterials can be applied for photothermal, photodynamic, and chemodynamic therapy of cancers/tumors. Fu

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Tiwari, Ankita, and Sanjay K. Jain. "Curcumin Based Drug Delivery Systems for Cancer Therapy." Current Pharmaceutical Design 26, no. 42 (2020): 5430–40. http://dx.doi.org/10.2174/1381612826666200429095503.

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Cancer accounts for the second major cause of death globally. Conventional cancer therapies lead to systemic toxicity that forbids their long term application. Besides, tumor resistance and recurrence have been observed in the majority of cases. Thus, the development of such therapy, which will pose minimum side effects, is the need of the hour. Curcumin or diferuloylmethane (CUR) is a natural polyphenol bioactive (obtained from Curcuma longa) which possesses anti-cancer and chemo-preventive activity. It acts by modulating various components of signaling cascades that are involved in cancer ce

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Silva, Allana Carvalho, Mirsiane Pascoal Costa, Thiago Medeiros Zacaron, et al. "The Role of Inhaled Chitosan-Based Nanoparticles in Lung Cancer Therapy." Pharmaceutics 16, no. 8 (2024): 969. http://dx.doi.org/10.3390/pharmaceutics16080969.

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Lung cancer is the leading cause of cancer-related mortality worldwide, largely due to the limited efficacy of anticancer drugs, which is primarily attributed to insufficient doses reaching the lungs. Additionally, patients undergoing treatment experience severe systemic adverse effects due to the distribution of anticancer drugs to non-targeted sites. In light of these challenges, there has been a growing interest in pulmonary administration of drugs for the treatment of lung cancer. This route allows drugs to be delivered directly to the lungs, resulting in high local concentrations that can

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Zhang, Zixuan. "Functionalized Nanoparticle Drug Delivery System Applied to the Diagnosis and Treatment of Tumor Cells." BIO Web of Conferences 72 (2023): 02013. http://dx.doi.org/10.1051/bioconf/20237202013.

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Chemotherapy is currently an important modality in the treatment of cancer and is widely used in the treatment of many cancers. However, the main problem with chemotherapy is the highly toxic side effects. How improve the efficacy of drugs and reduce their side effects has been a challenge for cancer treatment research. With the booming development of nanotechnology, functionalized nanomaterials are widely used for drug delivery and the treatment of tumors. Nanomaterials have unique physical, chemical, and optical properties, and the drug delivery system constructed by using multifunctional na

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Apostolou, Maria, Amos A. Fatokun, Sulaf Assi, and Iftikhar Khan. "Targeted Lipid-Based Drug Delivery Systems for Lung Cancer Therapy." Applied Sciences 14, no. 15 (2024): 6759. http://dx.doi.org/10.3390/app14156759.

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The aim of this study was to review the literature to explore the lipid-based drug delivery systems that have been investigated for improved treatment of lung cancers. Such lipid-based drug delivery systems include microemulsions, liposomes, transferosomes, niosomes, solid lipid nanoparticles (SLNs) and nanostructured lipid carriers (NLCs). In order to minimise the side effects of chemotherapeutic active pharmaceutical ingredients, surface modification with various ligands has been introduced so that the delivery system will attach only to specific receptors which are overexpressed in lung can

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Zhu, Chen. "Advances in Stimuli-Responsive Liposomes for Antitumour Drug Delivery Systems." Highlights in Science, Engineering and Technology 125 (February 18, 2025): 239–45. https://doi.org/10.54097/q02zx007.

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Cancer, a disease caused by the abnormal proliferation and spread of cells, is responsible for nearly 10 million deaths in 2020, accounting for 1/6 of all deaths worldwide. The pathogenesis of cancer is complex and is usually triggered by a combination of genetic mutations, environmental factors and lifestyle. Current treatments such as surgery, chemotherapy and radiotherapy are effective but have significant side effects such as fatigue, infection and pain. As a drug delivery system, liposomes have the advantages of drug protection, delayed release, and targeted therapy, which can effectively

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Chen, Fengqian, Yunzhen Shi, Jinming Zhang, and Qi Liu. "Nanoparticle-based Drug Delivery Systems for Targeted Epigenetics Cancer Therapy." Current Drug Targets 21, no. 11 (2020): 1084–98. http://dx.doi.org/10.2174/1389450121666200514222900.

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This review summarizes the epigenetic mechanisms of deoxyribonucleic acid (DNA) methylation, histone modifications in cancer and the epigenetic modifications in cancer therapy. Due to their undesired side effects, the use of epigenetic drugs as chemo-drugs in cancer therapies is limited. The drug delivery system opens a door for minimizing these side effects and achieving greater therapeutic benefits. The limitations of current epigenetic therapies in clinical cancer treatment and the advantages of using drug delivery systems for epigenetic agents are also discussed. Combining drug delivery sy

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S, Ali. "Transferosomes: A Versatile and Ultradeformable Approach for Targeted Delivery of Anticancer Drugs in the Treatment of Diverse Cancers." Bioequivalence & Bioavailability International Journal 8, no. 1 (2024): 1–10. http://dx.doi.org/10.23880/beba-16000228.

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Nanoparticles, particularly transferosomes, have emerged as promising drug delivery systems in the field of cancer therapy. With their unique properties and high adaptability, transferosomes have shown great potential in improving the targeted delivery of chemotherapeutic drugs, including through transdermal applications. This article provides a comprehensive review of the advancements and applications of transferosomes in cancer therapy and gene delivery; by highlighting the advantages of nanoparticles in cancer treatment, such as their ability to passively target tumors through the enhanced

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Dharmendra, Kumar. "Nanoparticulate system for cancer therapy: An updated review." International Journal of Nanomaterials, Nanotechnology and Nanomedicine 4, no. 2 (2018): 022–34. https://doi.org/10.17352/2455-3492.000027.

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Nowadays, pharmaceutical nanotechnology has been developed as the most emerging branch in the field of pharmacy. “Nanotechnology refers to the nanosize formulation. These nanoformulations may be used in treatment of various life-threading diseases like cancer. Due to the advantages of their nano size and shape, nanoformulations have been shown to be favorable drug delivery systems and may be useful for encapsulating and conjugating of drugs, enabling most precise tumor targeting and controlled release. Nanoparticle drug delivery system have several advantages such as enhanced intracellul

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Lin, Jiajun. "Intelligent Drug Delivery Systems Applying Cell Death Mechanisms in Cancer Therapy." Advances in Engineering Technology Research 13, no. 1 (2025): 1144. https://doi.org/10.56028/aetr.13.1.1144.2025.

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The diversity of cancers and drug resistance generated by cancer cells make traditional therapeutic approaches challenging. A detailed introduction is provided to a variety of cell death mechanisms such as apoptosis, necroptosis, pyroptosis, autophagy, ferroptosis, cuprotosis, and their applications in cancer therapy. By analysing the mechanism, this paper explores the principles of action and clinical applications of related drugs and materials, and investigates the potential of intelligent drug delivery systems in improving therapeutic efficacy and reducing side effects.

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Song, Zhuoran. "The Application of Nanomaterial-Based Drug Delivery in Cancer Therapy." Advances in Engineering Technology Research 13, no. 1 (2025): 1068. https://doi.org/10.56028/aetr.13.1.1068.2025.

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The effective delivery of drugs is crucial for the treatment of diseases. Due to the unique size advantages and characteristics of nanomaterials, they can effectively enhance the delivery efficiency of therapeutic agents to their target sites, maximizing the minimization of off-target rates in drug delivery. In cancer treatment, nanomaterials can achieve drug-targeted transport and combination therapies for tumors through functionalization, which holds important implications for enhancing the efficiency of cancer treatments. This article summarizes the advancements and challenges encountered i

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Qiu, Meng, Dou Wang, Weiyuan Liang, et al. "Novel concept of the smart NIR-light–controlled drug release of black phosphorus nanostructure for cancer therapy." Proceedings of the National Academy of Sciences 115, no. 3 (2018): 501–6. http://dx.doi.org/10.1073/pnas.1714421115.

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A biodegradable drug delivery system (DDS) is one the most promising therapeutic strategies for cancer therapy. Here, we propose a unique concept of light activation of black phosphorus (BP) at hydrogel nanostructures for cancer therapy. A photosensitizer converts light into heat that softens and melts drug-loaded hydrogel-based nanostructures. Drug release rates can be accurately controlled by light intensity, exposure duration, BP concentration, and hydrogel composition. Owing to sufficiently deep penetration of near-infrared (NIR) light through tissues, our BP-based system shows high therap

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Krishna Sailaja, Abbaraju. "Transferosomes-A Novel Carrier for Drug Delivery." Dermatology and Dermatitis 8, no. 5 (2023): 01–05. http://dx.doi.org/10.31579/2578-8949/132.

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Transferosomes are a type of lipid-based drug delivery system that is designed to enhance the delivery of drugs through the skin or other biological barriers. They are composed of phospholipids, surfactants, and sometimes cholesterol, which form a bilayer structure that encapsulates the drug. Additionally, transferosomes can be tailored to target specific tissues or cells, which can increase the efficacy of drugs while reducing the risk of side effects. For example, transferosomes can be designed to deliver drugs to cancer cells, allowing for targeted cancer therapy with fewer side effects tha

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Tran, Phuong H. L., Wei Duan, Beom-Jin Lee, and Thao T. D. Tran. "Nanogels for Skin Cancer Therapy via Transdermal Delivery: Current Designs." Current Drug Metabolism 20, no. 7 (2019): 575–82. http://dx.doi.org/10.2174/1389200220666190618100030.

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Background: Recently, several strategies have been proposed for skin cancer therapy by transdermal delivery, and particularly the use of nanotechnology. Methods: This process disrupts the stratum corneum to deliver a drug through the skin, allowing it to accumulate at the tumor site. Results: Nanogels are drug delivery systems that can be applied to many diseases. Nanogel engineering has been widely studied for use in drug delivery, particularly in cancer theranostics. This review summarizes specific strategies for using nanogels to treat skin cancer, a topic that is limited in recent literatu

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Maanvizhi, Saba, Vijayakumar Arumugam Ramamurthy, Athithan Velan, and Pugazhenthan Thangaraju. "Biomaterial implants in the treatment of oncology: a review." International Journal of Basic & Clinical Pharmacology 10, no. 7 (2021): 886. http://dx.doi.org/10.18203/2319-2003.ijbcp20212390.

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In globally, cancer is a second leading disease next to cardiovascular diseases in non-communicable diseases, which affect the all ages, sex, social status, ethnicity and primary cause of illness related death. Traditionally, systemic delivery drug systems like chemotherapy via oral capsule, injections of nanoparticles/micro particles, immunotherapy and others, which can inhibit or halt the progression of tumors. The short half-life of drugs which cannot achieve the targeted dose level to the tumor site and not able to target desired cell and commonly produces the organ toxicity. Recently, res

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Amin, Mohamadreza, Ann L. B. Seynhaeve, Majid Sharifi, Mojtaba Falahati, and Timo L. M. ten ten Hagen. "Liposomal Drug Delivery Systems for Cancer Therapy: The Rotterdam Experience." Pharmaceutics 14, no. 10 (2022): 2165. http://dx.doi.org/10.3390/pharmaceutics14102165.

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At the Nanomedicine Innovation Center (NICE) at the Erasmus MC in Rotterdam, we have approached the treatment of cancer by starting with a vision of first establishing a platform that enables us to overcome the low levels of drugs delivered to tumors and the issue of dose-limiting toxicity. Showing that a reduction of the volume of distribution, and a lowering of toxicity and side-effects, accompanied by augmented intratumoral drug delivery, could change outcomes in patients, paved the way to target, not only localized disease, but also systemic and metastasized cancers. In particular, the det

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Nikita. "Probiotic Bacteria for Targeted Drug Delivery: Potential Applications in Cancer Therapy." International Journal for Research Publication and Seminar 15, no. 3 (2024): 216–24. http://dx.doi.org/10.36676/jrps.v15.i3.1476.

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Conventional cancer treatments like radiation and chemotherapy frequently fail to meet expectations owing to side effects include systemic toxicity, lack of selectivity, and drug resistance. Targeted medication delivery systems have recently gained attention as a potential way to improve treatment effectiveness while reducing side effects. This research delves at the idea of using probiotic bacteria as a fresh way to deliver drugs to specific areas in cancer treatment. Due to their unique properties, such as their ability to colonise specific environments, interact with the immune system, and

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Gowtham, Pemula. "Advances in Targeted Drug Delivery in Melanoma." Asian Pacific Journal of Cancer Biology 6, no. 4 (2021): 331–37. http://dx.doi.org/10.31557/apjcb.2021.6.4.331-337.

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Cancer remains a major killer of mankind. Failure of conventional chemotherapy has resulted in recurrence and development of virulent multi drug resitant (MDR) phenotypes adding to the complexity and diversity of this deadly disease. Melanoma is the most aggressive and dangerous type of skin cancer, but its molecular mechanisms remain largely unclear Drug delivery systems (DDS) such as lipid- or polymer-based nanoparticles can be designed to improve the pharmacological and therapeutic properties of drugs administered parenterally with the emergence of nanotechnology, the use of nano-carriers i

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Premdas, T., A. Vennela, and G. Tejashwini. "Revolutionizing Cancer Treatment: The Role of Nanotechnology in Breast and Colorectal Cancer." Journal of Biomedical and Pharmaceutical Research 14, no. 2 (2025): 9–18. https://doi.org/10.32553/jbpr.v14i2.1254.

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Cancer remains a leading cause of mortality worldwide, with breast and colorectal cancers among the most prevalent. Despite advancements in conventional treatments such as chemotherapy, radiation therapy, and immunotherapy, challenges like systemic toxicity, drug resistance, and lack of targeted therapy persist. Nanotechnology has emerged as a promising approach in oncology, offering precise drug delivery, improved bioavailability, and reduced side effects. This review explores the role of nanotechnology in breast and colorectal cancer treatment, focusing on recent advancements in drug deliver

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Md, Shadab, Nabil A. Alhakamy, Shahid Karim, Gamal A. Gabr, Mohammad Kashif Iqubal, and Samar S. A. Murshid. "Signaling Pathway Inhibitors, miRNA, and Nanocarrier-Based Pharmacotherapeutics for the Treatment of Lung Cancer: A Review." Pharmaceutics 13, no. 12 (2021): 2120. http://dx.doi.org/10.3390/pharmaceutics13122120.

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Lung cancer is one of the most commonly diagnosed cancers and is responsible for a large number of deaths worldwide. The pathogenic mechanism of lung cancer is complex and multifactorial in origin. Thus, various signaling pathways as targets for therapy are being examined, and many new drugs are in the pipeline. However, both conventional and target-based drugs have been reported to present significant adverse effects, and both types of drugs can affect the clinical outcome in addition to patient quality of life. Recently, miRNA has been identified as a promising target for lung cancer treatme

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Smith, Howard. "Intrathecal Drug Delivery." Pain Physician 2s;11, no. 3;2s (2008): S89—S104. http://dx.doi.org/10.36076/ppj.2008/11/s89.

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Intrathecal analgesia has emerged as a key therapeutic option for pain relief for patients who have failed other treatment avenues as well as patients with adequate analgesia on high dose enteral or parenteral therapy but with unacceptable side effects. Intrethecal infusions of analgesics have been increasingly utilized since the later 1980s for the treatment of persistent pain. The purpose of this review is to provide research based clinical insight regarding the safe and appropriate use of the intrathecal infusion modality. Long-term intrathecal infusion analgesia or long-term intrathecal or

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Wang, Jin, Bohang Yin, Jiabing Lian, and Xia Wang. "Extracellular Vesicles as Drug Delivery System for Cancer Therapy." Pharmaceutics 16, no. 8 (2024): 1029. http://dx.doi.org/10.3390/pharmaceutics16081029.

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In recent decades, the pursuit of drug delivery systems has led to the development of numerous synthetic options aimed at enhancing drug efficacy while minimizing side effects. However, the practical application of these systems is often hindered by challenges such as inefficiency, cytotoxicity, and immunogenicity. Extracellular vesicles, natural carriers for drugs, emerge as promising alternatives with distinct advantages over synthetic carriers. Notably, EVs exhibit biocompatibility, low immunogenicity, and inherent tissue-targeting capabilities, thus opening new avenues for drug delivery st

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Kim, Kibeom, Jungmin Lee, and Myoung-Hwan Park. "Microbubble Delivery Platform for Ultrasound-Mediated Therapy in Brain Cancers." Pharmaceutics 15, no. 2 (2023): 698. http://dx.doi.org/10.3390/pharmaceutics15020698.

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The blood-brain barrier (BBB) is one of the most selective endothelial barriers that protect the brain and maintains homeostasis in neural microenvironments. This barrier restricts the passage of molecules into the brain, except for gaseous or extremely small hydrophobic molecules. Thus, the BBB hinders the delivery of drugs with large molecular weights for the treatment of brain cancers. Various methods have been used to deliver drugs to the brain by circumventing the BBB; however, they have limitations such as drug diversity and low delivery efficiency. To overcome this challenge, microbubbl

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Zhu, Dandan, Huanle Zhang, Yuanzheng Huang, et al. "A Self-Assembling Amphiphilic Peptide Dendrimer-Based Drug Delivery System for Cancer Therapy." Pharmaceutics 13, no. 7 (2021): 1092. http://dx.doi.org/10.3390/pharmaceutics13071092.

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Despite being a mainstay of clinical cancer treatment, chemotherapy is limited by its severe side effects and inherent or acquired drug resistance. Nanotechnology-based drug-delivery systems are widely expected to bring new hope for cancer therapy. These systems exploit the ability of nanomaterials to accumulate and deliver anticancer drugs at the tumor site via the enhanced permeability and retention effect. Here, we established a novel drug-delivery nanosystem based on amphiphilic peptide dendrimers (AmPDs) composed of a hydrophobic alkyl chain and a hydrophilic polylysine dendron with diffe

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Iravani, Siavash, and Rajender S. Varma. "Nanosponges for Drug Delivery and Cancer Therapy: Recent Advances." Nanomaterials 12, no. 14 (2022): 2440. http://dx.doi.org/10.3390/nano12142440.

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Nanosponges with three-dimensional (3D) porous structures, narrow size distribution, and high entrapment efficiency are widely engineered for cancer therapy and drug delivery purposes. They protect the molecular agents from degradation and help to improve the solubility of lipophilic therapeutic agents/drugs with targeted delivery options in addition to being magnetized to attain suitable magnetic features. Nanosponge-based delivery systems have been applied for cancer therapy with high specificity, biocompatibility, degradability, and prolonged release behavior. In this context, the drug load

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