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Relevant bibliographies by topics / Drug Release Kinetics / Dissertations / Theses

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Dissertations / Theses on the topic 'Drug Release Kinetics'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

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1

Jones, Stephen Joseph. "Investigating nonlinear enzyme kinetics as an internal control system for nanoreactor drug release." Thesis, University of Leeds, 2018. http://etheses.whiterose.ac.uk/22207/.

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The improper administration of therapeutic compounds is not only financially inefficient, but, there exists a very real risk of harmful, or potentially life-threatening effects. To gain control, nano-drug delivery systems provide a discernible option for temporal and spatial regulation of drug bioavailability within the body. In current regimes, temporal control is realised through gradual release over an extended period of time, or triggered release in response to a change in the physiochemical environment. Of course, when considering the design of an ideal drug delivery system, we think of a

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2

He, Xingyu. "Long-term Light-activated Drug Delivery Systems." University of Cincinnati / OhioLINK, 2020. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1613752062550859.

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3

Fugit, Kyle Daniel. "QUANTIFICATION OF FACTORS GOVERNING DRUG RELEASE KINETICS FROM NANOPARTICLES: A COMBINED EXPERIMENTAL AND MECHANISTIC MODELING APPROACH." UKnowledge, 2014. http://uknowledge.uky.edu/pharmacy_etds/37.

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Advancements in nanoparticle drug delivery of anticancer agents require mathematical models capable of predicting in vivo formulation performance from in vitro characterization studies. Such models must identify and incorporate the physicochemical properties of the therapeutic agent and nanoparticle driving in vivo drug release. This work identifies these factors for two nanoparticle formulations of anticancer agents using an approach which develops mechanistic mathematical models in conjunction with experimental studies. A non-sink ultrafiltration method was developed to monitor liposomal rel

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4

Liu, Quan. "Development of a novel gastro-retentive delivery system using alfuzosin HCl as a model drug." Diss., Temple University Libraries, 2010. http://cdm16002.contentdm.oclc.org/cdm/ref/collection/p245801coll10/id/80170.

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Pharmaceutics;<br>Ph.D.<br>The objectives of this project encompass the design and development of a drug delivery system to continuously deliver therapeutic agents from the stomach to the proximal region of the intestine. The delivery system designed would have sufficient gastric residence time together with near zero-order release kinetics. The physicochemical properties pertaining to the formulation development of the model drug (alfuzosin HCl) were evaluated. Excipients were selected based on the studies of their physicochemical properties and compatibility with the active ingredient. Gast

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5

Modi, Sweta. "The Critical Role of Mechanism-Based Models for Understanding and Predicting Liposomal Drug Loading, Binding and Release Kinetics." UKnowledge, 2013. http://uknowledge.uky.edu/pharmacy_etds/19.

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Liposomal delivery systems hold considerable promise for improvement of cancer therapy provided that critical formulation design criteria can be met. The main objective of the current project was to enable quality by design in the formulation of liposomal delivery systems by developing comprehensive, mechanism-based mathematical models of drug loading, binding and release kinetics that take into account not only the therapeutic requirement but the physicochemical properties of the drug, the bilayer membrane, and the intraliposomal microenvironment. Membrane binding of the drug affects both dru

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6

Cui, Yong. "Enhanced Release of Lidocaine From Supersaturated Solutions of Lidocaine In A Pressure Sensitive Adhesive." The Ohio State University, 2003. http://rave.ohiolink.edu/etdc/view?acc_num=osu1054210962.

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7

Pavurala, Naresh. "Oral Drug Delivery -- Molecular Design and Transport Modeling." Diss., Virginia Tech, 2013. http://hdl.handle.net/10919/53505.

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One of the major challenges faced by the pharmaceutical industry is to accelerate the product innovation process and reduce the time-to-market for new drug developments. This involves billions of dollars of investment due to the large amount of experimentation and validation processes involved. A computational modeling approach, which could explore the design space rapidly, reduce uncertainty and make better, faster and safer decisions, fits into the overall goal and complements the product development process. Our research focuses on the early preclinical stage of the drug development process

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8

GUPTA, PREETI. "HYDROGEL BASED WOUND DRESSING MATERIAL." Thesis, DELHI TECHNOLOGICAL UNIVERSITY, 2021. http://dspace.dtu.ac.in:8080/jspui/handle/repository/18806.

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Weak mechanical strength of hydrogels in wet condition limits their use for load bearing applications. Their mechanical strength can be raised by grafting them over some support or by converting them into nanofibrous form. Present thesis is focused on the preparation of poly (acrylamide-co-acrylic acid) hydrogel grafted over cotton fabric using two different cross-linkers i.e. PEG and MBAAm for making medicated dressing and nanofibers of hydrogel of poly (acrylamide-co-acrylic acid). FTIR was used to confirm the insertion of cross-links into the polymer chains. Grafting of uniform hydro

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9

Lee, Tak-yee. "Part 1: Computer aided dosage form design: theory and applications. Part 2: Kinetics and mechanism of captopril oxidation in aqueous solutions under controlled oxygen partial pressure /." The Ohio State University, 1986. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487266011224445.

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10

Jacob, Dolly. "Investigation into reliability and performance of an implantable closed-loop insulin delivery device." Thesis, De Montfort University, 2014. http://hdl.handle.net/2086/11126.

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An implantable closed-loop insulin delivery device (INsmart device) containing a glucose responsive gel has been developed within the INsmart research group, over a period of 10 years, to mimic pancreas. In this thesis, the reliability and performance capability of the INsmart device was studied for future clinical use. Investigations into the device material compatibility with insulin solution, assessed by monitoring insulin loss and degradant formation over a period of 31 days using RP-HPLC have shown that stainless steel and titanium are the most compatible materials. Polycarbonate contribu

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11

Knaack, Sven. "Entwicklung und Charakterisierung von Scaffolds auf Basis von mineralisiertem Kollagen zur gezielten Wirkstofffreisetzung für die Knochengewebe-Regeneration." Doctoral thesis, Saechsische Landesbibliothek- Staats- und Universitaetsbibliothek Dresden, 2016. http://nbn-resolving.de/urn:nbn:de:bsz:14-qucosa-188547.

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Beim Tissue Engineering ist die Vaskularisierung von größeren Zell-Matrix-Konstrukten nach Implantation bis heute ein großes Problem. Durch das initiale Fehlen eines mikrovaskulären Netzwerkes kommt es zu einem raschen Zellsterben im Scaffold. Aufgrund dessen war das Ziel dieser Arbeit, im Sinne des in situ-Tissue Engineering ein Scaffold auf Basis von mineralisiertem Kollagen zu entwickeln, welches mit dem angiogenen Wachstumsfaktor VEGF funktionalisiert wird, um den Prozess der Vaskularisierung – die Einsprossung von Blutgefäßen – zu fördern und gleichzeitig durch Chemoattraktion in vivo Z

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12

ANGELLOTTI, Giuseppe. "Sviluppo di spugne bioerodibili multifunzionali per la promozione di processi riparativi mediante il rilascio controllato di agenti antibiotici e antiossidanti. Utilizzo in chirurgia orale." Doctoral thesis, Università degli Studi di Palermo, 2023. https://hdl.handle.net/10447/580944.

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La salute delle strutture molli e dure del cavo orale è essenziale non solo per preservare le funzioni ad esse direttamente associate, ma anche per promuovere la salute generale dell’organismo. Tra le problematiche di maggiore interesse clinico a carico della cavità orale ritroviamo: i) le complicazioni post-operatorie che possono verificarsi a seguito di comuni avulsioni dentali che, se non trattate tempestivamente, possono sfociare in gravi parodontiti; ii) i fenomeni di osteonecrosi a carico di mascella e mandibola associate a trattamenti farmacologici nonché alla radioterapia; iii) il carc

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13

Soutif, Jean-Claude. "Etude de l'addition des acides carboxyliques sur les structures oxiranne : application aux polymeres epoxydes." Le Mans, 1987. http://www.theses.fr/1987LEMA1010.

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La modification chimique au deuxieme degre de polymeres epoxydes a ete etudiee pour developper une methode de fixation de principes actifs (medicaments, colorants, complexants) comportant des fonctions acides, sur des supports macromoleculaires. Le catalyseur est un sel de tetramethylammonium de l'acide a fixer. Epoxydation de polyisoprene et polybutadiene

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14

Sant, Shilpa. "Polymeric nanoparticles : from microporosity and drug release kinetics to cellular interactions." Thèse, 2007. http://hdl.handle.net/1866/6653.

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15

Yi-LiTang and 唐義立. "Encapsulation Efficiency and Release Kinetics of Water-Soluble Drug in Ethosome-Like Catanionic Vesicles." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/47964382850050026789.

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16

Yang, S., X. Yin, C. Wang, et al. "Release behaviour of single pellets and internal fine 3D structural features co-define the in vitro drug release profile." 2014. http://hdl.handle.net/10454/10557.

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No<br>Multi-pellet formulations are advantageous for the controlled release of drugs over single-unit dosage forms. To understand the diffusion controlled drug release mechanism, the pellet structure and drug release from a single pellet (not at dose level) were studied using synchrotron radiation X-ray computed microtomography (SR-muCT) and a sensitive LC/MS/MS method. The purpose of this article is to introduce a powerful, non-invasive and quantitative technique for studying individual pellet microstructures and to investigate the relationship between the microstructure and drug release from

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17

Adams, Tiffany S. "Synthesis and characterization of artificial lipoprotein for targeted drug delivery ; influence of formulation factors on the drug release kinetics of whole and half controlled-release trazodone HCL tablets." 2004. http://purl.galileo.usg.edu/uga%5Fetd/adams%5Ftiffany%5Fs%5F200412%5Fphd.

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Thesis (Ph. D.)--University of Georgia, 2004.<br>Directed by James Price. Includes articles submitted to International journal of pharmaceutics, Journal of pahrmaceutical research, and Journal of pharmaceutical science. Includes bibliographical references.

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18

Sharma, R., Roderick Walker, and K. Pathak. "Evaluation of the kinetics and mechanism of drug release from Econazole nitrate nanosponge loaded Carbapol Hydrogel." 2011. http://hdl.handle.net/10962/d1006614.

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The objective of this study was to investigate the mechanism of release of econazole nitrate (EN) nanosponges loaded hydrogel and to compare it with EN hydrogel so as to develop an extended release topical drug delivery system of EN. Nanosponges of EN were prepared using ethyl cellulose and PVA by emulsion solvent evaporation method. On the basis of pharmacotechnical evaluation nanosponges with least particle size of 230.1 nm and good rheological properties were formulated as hydrogel (F1 – F7). In vitro drug release data of EN nanosponges loaded hydrogels in phosphate buffer pH 6.8 and 7.4 wh

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19

Liang, Liu Wen, and 劉文亮. "Drug Release and Skin Permeation Kineticks of Steroidal Drugs." Thesis, 1994. http://ndltd.ncl.edu.tw/handle/49448798084165094318.

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20

Lamontagne, Steven. "Three-Dimensional Model of the Release and Diffusion of Paclitaxel in the Stent-Polymer-Wall-Lumen System of a Blood Vessel." Thèse, 2018. http://hdl.handle.net/1866/22159.

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21

Grant, David William. "Reduced Burst Release of Bioactive rhBMP-2 from a Three-phase Composite Scaffold." Thesis, 2010. http://hdl.handle.net/1807/25605.

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Recombinant human bone morphogenic proteins (rhBMPs) are extensively studied and employed clinically for treatment of various bone defects. Current clinical delivery vehicles suffer wasteful burst releases that mandate supra-physiological dosing driving concerns over safety and cost. It was therefore investigated whether a unique drug delivery vehicle sequestered within a composite scaffold could lower the burst release of rhBMP-2. PLGA-calcium phosphate tri-phasic composite scaffolds delivered model protein BSA with burst release of ~13% and sustained kinetics of 0.5-1.5% BSA/day up to 45 day

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22

Umerska, A., Krzysztof J. Paluch, M. J. Santos-Martinez, C. Medina, O. I. Corrigan, and L. Tajber. "Chondroitin-based nanoplexes as peptide delivery systems-Investigations into the self-assembly process, solid-state and extended release characteristics." Thesis, 2015. http://hdl.handle.net/10454/9416.

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Yes<br>A new type of self-assembled polyelectrolyte complex nanocarrier composed of chondroitin (CHON) and protamine (PROT) was designed and the ability of the carriers to bind salmon calcitonin (sCT) was examined. The response of sCT-loaded CHON/PROT NPs to a change in the properties of the liquid medium, e.g. its pH, composition or ionic strength was studied and in vitro peptide release was assessed. The biocompatibility of the NPs was evaluated in Caco-2 cells. CHON/PROT NPs were successfully obtained with properties that were dependent on the concentration of the polyelectrolytes and their

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23

"Methods for Detection of Small Molecule-Protein Interactions." Doctoral diss., 2015. http://hdl.handle.net/2286/R.I.34938.

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abstract: Detection of molecular interactions is critical for understanding many biological processes, for detecting disease biomarkers, and for screening drug candidates. Fluorescence-based approach can be problematic, especially when applied to the detection of small molecules. Various label-free techniques, such as surface plasmon resonance technique are sensitive to mass, making it extremely challenging to detect small molecules. In this thesis, novel detection methods for molecular interactions are described. First, a simple detection paradigm based on reflectance interferometry

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24

Xu, Weijie. "Drug release and its relationship with kinetic and thermodynamic parameters of drug sorption onto polylactide, starch acetate, wheat gluten and soy protein fibers." 2009. http://proquest.umi.com/pqdweb?did=1709934761&sid=6&Fmt=2&clientId=14215&RQT=309&VName=PQD.

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Thesis (Ph.D.)--University of Nebraska-Lincoln, 2009.<br>Title from title screen (site viewed September 08, 2009). PDF text: ca. 195 p. UMI publication number: AAT 3352483. Includes bibliographical references. Also available in microfilm and microfiche formats.

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25

Graubner, Gitte. "Crystal Engineering in Nanoporous Matrices." Doctoral thesis, 2015. https://repositorium.ub.uni-osnabrueck.de/handle/urn:nbn:de:gbv:700-2015021213062.

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As former studies reveal, the nanoporous confinement could have influence on polymorphic drug crystallization. However, little attention has been paid to the question how crystallization of the commonly polymorphic drugs in nanoporous matrices influences the drug release. As a consequence, sufficient information about the crystallization conditions and their influence on phase behavior, crystal texture, and stability of polymorphs should be retrieved prior to drug delivery experiments. Drug release should be polymorph-selective and even crystal face-specific. Therefore, the topic of this PhD t

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26

Knaack, Sven. "Entwicklung und Charakterisierung von Scaffolds auf Basis von mineralisiertem Kollagen zur gezielten Wirkstofffreisetzung für die Knochengewebe-Regeneration." Doctoral thesis, 2015. https://tud.qucosa.de/id/qucosa%3A29043.

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Beim Tissue Engineering ist die Vaskularisierung von größeren Zell-Matrix-Konstrukten nach Implantation bis heute ein großes Problem. Durch das initiale Fehlen eines mikrovaskulären Netzwerkes kommt es zu einem raschen Zellsterben im Scaffold. Aufgrund dessen war das Ziel dieser Arbeit, im Sinne des in situ-Tissue Engineering ein Scaffold auf Basis von mineralisiertem Kollagen zu entwickeln, welches mit dem angiogenen Wachstumsfaktor VEGF funktionalisiert wird, um den Prozess der Vaskularisierung – die Einsprossung von Blutgefäßen – zu fördern und gleichzeitig durch Chemoattraktion in vivo Z

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27

Ferreira, Ana Vanessa Fernandes. "Incorporation of elastase inhibitor in silk fibroin nanoparticles for transdermal delivery." Master's thesis, 2013. http://hdl.handle.net/1822/28648.

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Dissertação de mestrado em Bioengenharia<br>Human neutrophil elastase, as inflammatory response, has the capacity to degrade collagen and elastin component of extracellular matrix, being extensively involved in wrinkles formation induced by UV radiation damage. In order to develop a cosmetic antiwrinkling emulsion, we incorporated a potent synthetic HNE inhibitor, sivelestat (IC50 = 44 nM, Ki = 0.2 μM), into biopolymeric nanoparticles prepared by high-energy emulsification methods. As nanomaterial was used Bombyx mori silk fibroin protein, an FDA approved natural biocompatible and biodeg

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