Log in

Relevant bibliographies by topics / Drug Release Kinetics / Journal articles

To see the other types of publications on this topic, follow the link: Drug Release Kinetics.

Journal articles on the topic 'Drug Release Kinetics'

Author: Grafiati

Published: 4 June 2021

Last updated: 26 July 2025

Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles

Select a source type:

Consult the top 50 journal articles for your research on the topic 'Drug Release Kinetics.'

Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.

You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.

Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.

1

Chakraborty, Santanu, Madhusmruti Khandai, Anuradha Sharma, Ch Patra, V. Patro, and Kalyan Sen. "Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations." Acta Pharmaceutica 59, no. 3 (2009): 313–23. http://dx.doi.org/10.2478/v10007-009-0025-8.

Full text

Abstract:

Effects of drug solubility on the release kinetics of water soluble and insoluble drugs from HPMC based matrix formulations The purpose of the present research work was to observe the effects of drug solubility on their release kinetics of water soluble verpamil hydrochloride and insoluble aceclofenac from hydrophilic polymer based matrix formulations. Matrix formulations were prepared by the direct compression method. The formulations were evaluated for various physical parameters. Along with the dynamics of water uptake and erosion, SEM and in vitro drug release of the tablets were studied.

APA, Harvard, Vancouver, ISO, and other styles

2

Nooreen, Hari kiriti varma G, and Vijayakuchana. "Formulation and in vitro evaluation of sustained release matrix tablets of Rimopride Citrate Dihydrate." Frontier Journal of Pharmaceutical Sciences and Research 7, no. 1 (2024): 1–5. https://doi.org/10.5281/zenodo.10575985.

Full text

Abstract:

Drugs are most frequently administered by oral route. Although a few drugs taken orally are intended to be dissolved in the mouth, nearly all drugs taken orally are swallowed. A few drugs such as antacids are swallowed for their local action in the gastrointestinal tracts. Hence the above study demonstrated that combination of HPMC K4M and HPMC K15M can be used to formulate sustained release matrix tablets of Rimopride Citrate Dihydrate. This can sustain the drug release up to 24 hours as per standard dissolution profile. This can be expected to reduce the frequency of administration and decre

APA, Harvard, Vancouver, ISO, and other styles

3

Kumar, Putta Rajesh, Meena N, Poojitha P, Sowjanya P, Shivaleela U, and Sharma JVC. "Formulation Design and in Vitro Evaluation Studies of Antidepressant Venlafaxine Hydrochloride Oral Drug Delivery Systems." Journal of Biomedical and Pharmaceutical Research 13, no. 2 (2024): 51–63. http://dx.doi.org/10.32553/jbpr.v13i2.1084.

Full text

Abstract:

Background: Venlafaxine Hydrochloride a serotonin, nor epinephrine reuptake inhibitor, oral antidepressant used to treat depression. Objective: The present study was aimed at studying controlled release of Venlafaxine Hydrochloride with Guargum, Hydroxy propyl methyl cellulose as matrix polymers, Micro crystalline cellulose as binder and Dicalcium phosphate as diluent filler. Methods: Tablets were studied for pre, post compression, swelling and in vitro dissolution studies. Drug release was analyzed by release kinetic models. Results: Preformulation studies revealed that the drug procured was

APA, Harvard, Vancouver, ISO, and other styles

4

Zhu, Weiwei, Jiajie Long, and Meiwu Shi. "Release Kinetics Model Fitting of Drugs with Different Structures from Viscose Fabric." Materials 16, no. 8 (2023): 3282. http://dx.doi.org/10.3390/ma16083282.

Full text

Abstract:

(1) Background: It is simpler and more environmentally friendly to use supercritical CO2 fluid technology to process skincare viscose fabrics. Therefore, it is significant to study the release properties of drug-loaded viscose fabrics to choose suitable skincare drugs. In this work, the release kinetics model fittings were investigated in order to clarify the release mechanism and provide a theoretical basis for processing skincare viscose fabrics with supercritical CO2 fluid. (2) Methods: Nine kinds of drugs with different substituent groups, different molecular weights, and different substit

APA, Harvard, Vancouver, ISO, and other styles

5

Arefin, Paroma, Ikramul Hasan, Md Shfiqul Islam, and Md Selim Reza. "Formulation and In vitro Evaluation of Eudragit RL 100 Loaded Fexofenadine HCl Microspheres." Bangladesh Pharmaceutical Journal 19, no. 1 (2016): 58–67. http://dx.doi.org/10.3329/bpj.v19i1.29240.

Full text

Abstract:

The present study deals with the formulation and evaluation of Fexofenadine hydrochloride (HCl) loaded sustained release microspheres by emulsion solvent evaporation method with Eudragit RL 100. The effects of percent drug loading on drug encapsulation efficiency, drug content and drug release rate were assessed. In vitro dissolution study was performed spectrophotometrically according to USP paddle method using phosphate buffer (pH 6.8) for 10 hours. The release rate of Fexofenadine HCl from the microspheres was significantly increased with the increase of drug loading. The drug release patte

APA, Harvard, Vancouver, ISO, and other styles

6

Mitran, Raul-Augustin, Daniela Berger, Jeanina Pandele-Cusu, and Cristian Matei. "Effect of Aluminum Incorporation into Mesoporous Aluminosilicate Framework on Drug Release Kinetics." Journal of Nanomaterials 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/9864396.

Full text

Abstract:

Mesoporous silica materials are promising nanocarriers for the development of drug delivery systems. In this study, the influence of pore size, volume, surface area, and doping the silica framework on the release kinetics of a model drug, metoprolol, has been studied. 20% or 50% wt. therapeutic agent was loaded into the carrier mesopores through incipient wetness impregnation. The carriers and drug-loaded samples have been characterized by small- and wide-angle X-ray diffraction, FT-IR spectroscopy, scanning electron microscopy, and nitrogen adsorption-desorption isotherms. The in vitro releas

APA, Harvard, Vancouver, ISO, and other styles

7

Suprianto. "Analisis Kinetika Pelepasan Teofilin dari Granul Matriks Kitosan." JURNAL ILMIAH MANUNTUNG 2, no. 1 (2016): 70–80. https://doi.org/10.5281/zenodo.1246129.

Full text

Abstract:

Moment the drug dosage form development, it is important to study the drug release or dissolution that is recognized as an element in drug development. Mathematical models could help optimize the design of drugs to produce models of drug release information. Analysis of quantitative values obtained when depicting dissolution drug release profiles more easily when the mathematical concepts used to describe the drug release kinetics model. The model release of drugs known includes zero order, first order, Higuchi models, models Hixon Crowell and Peppas Korsmeyer models. The purpose of this

APA, Harvard, Vancouver, ISO, and other styles

8

Dumitriu, Raluca Petronela, Ana Maria Oprea, and Cornelia Vasile. "Kinetics of Swelling and Drug Release from PNIPAAm/Alginate Stimuli Responsive Hydrogels." Solid State Phenomena 154 (April 2009): 17–22. http://dx.doi.org/10.4028/www.scientific.net/ssp.154.17.

Full text

Abstract:

Stimuli responsive hydrogels are very attractive for applications in sustained and/or targeted drug delivery systems. As the release of drugs is related to the swelling behavior of hydrogels, the swelling kinetic studies become of great importance to appreciate the release kinetics from hydrogel matrices. Hydrogels with high performance properties have been prepared from N-isopropylacryl amide (NIPAAm) and sodium alginate, crosslinked with N,N`-methylene-bis-(acrylamide) (MBAAm). This study is focused on the investigation of swelling and drug release kinetics, coupled by morphological studies.

APA, Harvard, Vancouver, ISO, and other styles

9

Das, Utpal, Shimul Halder, Abul Kalam Lutful Kabir, Harun Or Rashid, and Abu Shara Shamsur Rouf. "Development and in vitro Evaluation of Sustained Release Matrix Tablets of Indapamide from Methocel® K15 MCR and K100 LVCR." Dhaka University Journal of Pharmaceutical Sciences 10, no. 2 (2012): 87–92. http://dx.doi.org/10.3329/dujps.v10i2.11785.

Full text

Abstract:

Indapamide, a low-dose thiazide-type diuretic, is used for the treatment of essential hypertension. In this study, we developed an indapamide sustained release formulation using Methocel K15 MCR (a modified hydroxypropyl methylcellulose), Methocel K100 LVCR (a modified hydroxypropyl methylcellulose), magnesium stearate, talc and starch 1500 by direct compression. The powders for tableting were evaluated for angle of repose, loose bulk density, tapped bulk density, compressibility index, total porosity etc. The tablets were subjected to thickness, weight variation test, hardness, friability and

APA, Harvard, Vancouver, ISO, and other styles

10

Loew, Stephan, Alfred Fahr, and Sylvio May. "Modeling the Release Kinetics of Poorly Water-Soluble Drug Molecules from Liposomal Nanocarriers." Journal of Drug Delivery 2011 (June 7, 2011): 1–10. http://dx.doi.org/10.1155/2011/376548.

Full text

Abstract:

Liposomes are frequently used as pharmaceutical nanocarriers to deliver poorly water-soluble drugs such as temoporfin, cyclosporine A, amphotericin B, and paclitaxel to their target site. Optimal drug delivery depends on understanding the release kinetics of the drug molecules from the host liposomes during the journey to the target site and at the target site. Transfer of drugs in model systems consisting of donor liposomes and acceptor liposomes is known from experimental work to typically exhibit a first-order kinetics with a simple exponential behavior. In some cases, a fast component in t

APA, Harvard, Vancouver, ISO, and other styles

11

Debatri, Roy, Das Sudipta, Panda Anumoy, et al. "Development and Comparative Analysis of Metronidazole Microspheres Prepared with Different Combinations of Polymers Using Ionotropic Gelation Technique." Indian Journal of Science and Technology 16, no. 42 (2023): 3821–28. https://doi.org/10.17485/IJST/v16i42.2293.

Full text

Abstract:

Abstract <strong>Objective:</strong> Basis of this experiment was progressive preparation and evaluation of generated metronidazole loaded microsphere by desired ratio of polymers which can improve its therapeutic efficacy and reduce the need for frequent dosing. The use of microspheres can improve the bioavailability of the medication by protecting it from degradation and improving its absorption in the body. Drug release pattern can be altered by swelling Index and diffusion.<strong> Methods:</strong> Metronidazole loaded microsphere was prepared by ionotropic gelation techniq

APA, Harvard, Vancouver, ISO, and other styles

12

Gierszewska, Magdalena, Jadwiga Ostrowska-Czubenko, and Ewelina Chrzanowska. "CHARACTERISTICS OF ASCORBIC ACID RELEASE FROM TPP-CROSSLINKED CHITOSAN/ALGINATE POLYELECTROLYTE COMPLEX MEMBRANES." Progress on Chemistry and Application of Chitin and its Derivatives XXIII (September 10, 2018): 76–87. http://dx.doi.org/10.15259/pcacd.23.007.

Full text

Abstract:

Chitosan/alginate polyelectrolyte complex membranes (Ch/Alg) additionally cross-linked with tripolyphosphate (TPP) and containing ascorbic acid (AA) were prepared. The dynamic swelling behaviour of Ch/Alg/TPP and ascorbic acid release from the membrane were characterised in different buffer solutions. It has been found that the pH of the buffer solution affects the swelling and release behaviour of AA. Ascorbic acid release, observed over a period of 360 min, exhibited a biphasic pattern, characterised by a fast initial burst release, followed by a slow, sustained release. Different mathematic

APA, Harvard, Vancouver, ISO, and other styles

13

Chudoba, Dorota, Monika Jażdżewska, Katarzyna Łudzik, Sebastian Wołoszczuk, Ewa Juszyńska-Gałązka, and Mikołaj Kościński. "Description of Release Process of Doxorubicin from Modified Carbon Nanotubes." International Journal of Molecular Sciences 22, no. 21 (2021): 12003. http://dx.doi.org/10.3390/ijms222112003.

Full text

Abstract:

The article discusses the release process of doxorubicin hydrochloride (DOX) from multi-wall carbon nanotubes (MWCNTs). The studies described a probable mechanism of release and actions between the surface of functionalized MWCNTs and anticancer drugs. The surface of carbon nanotubes (CNTs) has been modified via treatment in nitric acid to optimize the adsorption and release process. The modification efficiency and physicochemical properties of the MWCNTs+DOX system were analyzed by using SEM, TEM, EDS, FTIR, Raman Spectroscopy and UV-Vis methods. Based on computer simulations at pH 7.4 and th

APA, Harvard, Vancouver, ISO, and other styles

14

Nining, Nining, Anisa Amalia, and Raditya Naufal Riyanto. "The effect of HPMC-K15M and guar gum as polymer-coated for sustained-released tablet: disintegration and release kinetics." Pharmaciana 14, no. 3 (2024): 396–407. https://doi.org/10.12928/pharmaciana.v14i3.28104.

Full text

Abstract:

Polymeric coating films are able to control tablet drug release rate depending on polymer physicochemical properties. Guar gum and HPMC-K15M (GG/HPMC-K15M) can be a coating polymer in sustained-release tablets. This study aims to characterize the disintegration and drug release kinetics on theophylline sustained-release tablets coated with GG/HPMC-K15M. The film coating was made with variations of the GG/HPMC-K15M ratio of 1:3 (F1), 1:4 (F2), and 1:5 (F3). Granules were preformulated regarding LOD, granule size distribution, packing, and flow properties. Film coating was carried out using a li

APA, Harvard, Vancouver, ISO, and other styles

15

Wani, Taha Umair, and Nisar Ahmad Khan. "Formulation of Carbopol Capsules for Sustained Release of Losartan Potassium." Journal of Drug Delivery and Therapeutics 9, no. 2-s (2019): 92–97. http://dx.doi.org/10.22270/jddt.v9i2-s.2468.

Full text

Abstract:

Sustained release formulations have been extensively studied for their benefits in improving various physicochemical and pharmacokinetic properties of large number of drugs. The aim of this study was to develop and evaluate sustained release capsules of losartan potassium in order to provide drug release over a long period of time. This allows the drug much time for absorption in gastrointestinal tract (GIT) and hence may increase the bioavailability of the drug. Carbopol 971 P was used as rate controlling polymer for the preparation of capsules. The capsules were evaluated for matrix integrit

APA, Harvard, Vancouver, ISO, and other styles

16

Kusum, ,., Avinash Kumar Gupta, Manish Kumar Gupta, and Vijay Sharma. "A Review on Formulation and Evaluation of Sustained Release Tablet of Devilproex Sodium." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 660–62. http://dx.doi.org/10.22270/jddt.v9i4.3067.

Full text

Abstract:

An appropriately designed drug delivery system can be a major step towards solving these two problems. This technique for the drug administration is termed as ‘sustained release’ or ‘controlled release. Drugs with dosage not exceeding 125mg – 325mg are more suited as extended release products in order to limit the size of the delivery system. In the case of soluble matrix the matrix swells or dissolves. These matrices then undergo surface erosion with little or no bulk erosion. Divalproex sodium dissociates to the valproate ion in the gastrointestinal tract. The mechanisms by which valproate e

APA, Harvard, Vancouver, ISO, and other styles

17

Ekenna, Ifeoma Cynthia, and Sunday Okorie Abali. "Comparison of the Use of Kinetic Model Plots and DD Solver Software to Evaluate the Drug Release from Griseofulvin Tablets." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 5–13. http://dx.doi.org/10.22270/jddt.v12i2-s.5402.

Full text

Abstract:

Awareness of the release kinetics of active drugs is important in formulating drugs that have the desired delivery and in predicting the behaviour of the formulated drug in vivo. The study aims to determine the mechanism of drug release from griseofulvin tablets formulated with different surfactants using mathematical models and to compare the use of graphs and DD solver software in fitting dissolution profiles to kinetic models. The batches P1 -P3 were composed of the surfactant - PEG 4000 in different concentrations. A control batch without surfactant and a commercial brand (Mycoxyl 500) wer

APA, Harvard, Vancouver, ISO, and other styles

18

Ekenna, Ifeoma Cynthia, and Sunday Okorie Abali. "Comparison of the Use of Kinetic Model Plots and DD Solver Software to Evaluate the Drug Release from Griseofulvin Tablets." Journal of Drug Delivery and Therapeutics 12, no. 2-S (2022): 5–13. http://dx.doi.org/10.22270/jddt.v12i2-s.5402.

Full text

Abstract:

Awareness of the release kinetics of active drugs is important in formulating drugs that have the desired delivery and in predicting the behaviour of the formulated drug in vivo. The study aims to determine the mechanism of drug release from griseofulvin tablets formulated with different surfactants using mathematical models and to compare the use of graphs and DD solver software in fitting dissolution profiles to kinetic models. The batches P1 -P3 were composed of the surfactant - PEG 4000 in different concentrations. A control batch without surfactant and a commercial brand (Mycoxyl 500) wer

APA, Harvard, Vancouver, ISO, and other styles

19

Al-Ali, Maha. "Comparative analyses of Weibull model and conventional kinetics models of drug release of formulated multi-component tablets." Al-Qadisiyah Journal for Engineering Sciences 18, no. 2 (2025): 107–16. https://doi.org/10.30772/qjes.2024.148019.1175.

Full text

Abstract:

The Kinetics study of drug release is an essential requirement to examine the capability of the drug formulation to modulate with the typical drug release profile. In the present work, hence, Weibull model and other traditional drug release models are selected to investigate the release of tablets prepared using different drying techniques in a simulated abdominal solution. These tablets are prepared using electromagnetic microwave irradiation tablet (MVT), convective drying (CVT), freeze drying (FRT), vacuum drying (VAT), and that without drying process (NDT). This study aims to compare the W

APA, Harvard, Vancouver, ISO, and other styles

20

Sha’at, Mousa, Lacramioara Ochiuz, Cristina Marcela Rusu, et al. "Experimental and Theoretical Design on the Development of Matrix Tablets with Multiple Drug Loadings Aimed at Optimizing Antidiabetic Medication." Pharmaceutics 16, no. 12 (2024): 1595. https://doi.org/10.3390/pharmaceutics16121595.

Full text

Abstract:

Background: Diabetes is a growing global health crisis that requires effective therapeutic strategies to optimize treatment outcomes. This study aims to address this challenge by developing and characterizing extended-release polymeric matrix tablets containing metformin hydrochloride (M-HCl), a first-line treatment for type 2 diabetes, and honokiol (HNK), a bioactive compound with potential therapeutic benefits. The objective is to enhance glycemic control and overall therapeutic outcomes through an innovative dual-drug delivery system. Methods: The tablets were formulated using hydrophilic p

APA, Harvard, Vancouver, ISO, and other styles

21

Sreekanth Reddy, O., M. C. S. Subha, T. Jithendra, C. Madhavi, and K. Chowdoji Rao. "Fabrication of Gelatin/Karaya gum blend microspheres for the controlled release of Distigmine bromide." Journal of Drug Delivery and Therapeutics 9, no. 3-s (2019): 1–11. http://dx.doi.org/10.22270/jddt.v9i3-s.2720.

Full text

Abstract:

This paper reports the fabrication of gelatin/karaya gum microspheres by emulsion crosslinking method for controlled release of distigmine bromide. The microspheres were crosslinked with the help of glutaraldehyde and used for controlled oral delivery of distigmine bromide. The obtained microspheres were characterized by Fourier transform infrared spectroscopy, differential scanning calorimetry, X-ray diffraction and scanning electron microscopy. Drug release kinetics of the microspheres is investigated in simulated intestinal fluid pH 7.4 at 37oC. Results illustrated that microspheres was inf

APA, Harvard, Vancouver, ISO, and other styles

22

Saini, Mohit. "Release Kinetic Study of Matrix Type Transdermal Patch Using anAnalgesic Drug." IAR Journal of Medicine and Surgery Research 1, no. 1 (2020): 1–8. http://dx.doi.org/10.70818/iarjmsr.2020.v01i01.01.

Full text

Abstract:

Transdermal therapeutic systems are defined as a self-contained, distinct dosage forms which, when applied to the intact skin, deliver the drug, through the skin at control rate to the systemic circulation. TDDS characterizes one of the most quickly advancing areas of novel drug delivery. TDDS are designed for controlled liberate of drug through the skin into systemic circulation maintaining consistent efficacy and reducing dose of the drug and its related side effects. Present study was conducted to prepare transdermal patch of Tramadol HCL with permeation enhancer to diminish extra side effe

APA, Harvard, Vancouver, ISO, and other styles

23

Khan, Kamran Ahmad, Gul Majid Khan, Muhammad Muzammal, et al. "Preparation of Losartan Potassium Controlled Release Matrices and In-Vitro Investigation Using Rate Controlling Agents." Molecules 27, no. 3 (2022): 864. http://dx.doi.org/10.3390/molecules27030864.

Full text

Abstract:

Controlled release matrices have predictable drug release kinetics, provide drugs for an extended period of time, and reduce dosing frequency with improved patient compliance as compared with conventional tablet dosage forms. In the current research work, losartan potassium controlled release matrix tablets were fabricated and prepared with rate altering agents; that is, Ethocel grade 100 combined with Carbopol 934PNF. Various drug to polymer ratios were used. HPMC, CMC, and starch were incorporated in some of the matrices by replacing some amount of filler (5%). The direct compression method

APA, Harvard, Vancouver, ISO, and other styles

24

Yang, Keni, Karolina Tran, and Anna Salvati. "Tuning Liposome Stability in Biological Environments and Intracellular Drug Release Kinetics." Biomolecules 13, no. 1 (2022): 59. http://dx.doi.org/10.3390/biom13010059.

Full text

Abstract:

Ideal drug carriers should be stable in biological environments but eventually release their drug load once inside the targeted cells. These two aspects can be in contrast with each other, thus they need to be carefully tuned in order to achieve the desired properties for specific applications. Quantifying drug release profiles in biological environments or inside cells can be highly challenging, and standard methods to determine drug release kinetics in many cases cannot be applied to complex biological environments or cells. Within this context, the present work combined kinetic studies by f

APA, Harvard, Vancouver, ISO, and other styles

25

Quesada-Pérez, Manuel, Luis Pérez-Mas, David Carrizo-Tejero, José-Alberto Maroto-Centeno, María del Mar Ramos-Tejada, and Alberto Martín-Molina. "Coarse-Grained Simulations of Release of Drugs Housed in Flexible Nanogels: New Insights into Kinetic Parameters." Polymers 14, no. 21 (2022): 4760. http://dx.doi.org/10.3390/polym14214760.

Full text

Abstract:

The diffusion-controlled release of drugs housed in flexible nanogels has been simulated with the help of a coarse-grained model that explicitly considers polymer chains. In these in silico experiments, the effect of its flexibility is assessed by comparing it with data obtained for a rigid nanogel with the same volume fraction and topology. Our results show that the initial distribution of the drug can exert a great influence on the release kinetics. This work also reveals that certain surface phenomena driven by steric interactions can lead to apparently counterintuitive behaviors. Such phen

APA, Harvard, Vancouver, ISO, and other styles

26

Batul, Rahila, Abdul Khaliq, Ahmed Alafnan, Mrinal Bhave, and Aimin Yu. "Investigation of Gentamicin Release from Polydopamine Nanoparticles." Applied Sciences 12, no. 13 (2022): 6319. http://dx.doi.org/10.3390/app12136319.

Full text

Abstract:

Polydopamine (PDA), being highly reactive in nature, has acquired great attention in multi-disciplinary fields. Owing to its fascinating properties, including its biocompatible, non-toxic and readily bio-degradative nature, we investigated the drug loading and release behavior, using an aminoglycoside antibiotic gentamicin (G) as a model drug. The gentamicin was loaded into the PDA nanoparticles (NPs) via an in situ polymerization method. The release kinetics of the gentamicin was then studied in pH 3, 5 and 7.4. Two batches with varied gentamicin loadings, G-PDA NPs 1:1 (with approx. 84.1% lo

APA, Harvard, Vancouver, ISO, and other styles

27

Kumar, B., and G. Jeyabalan. "Development of Anti-diabetic Niosomes Formulation Containing Metformin and Gliclazide." Indian Journal of Pharmaceutical and Biological Research 5, no. 02 (2017): 24–28. http://dx.doi.org/10.30750/ijpbr.5.2.5.

Full text

Abstract:

Metformin/Gliclazide niosomes were formulated with span 60 by ether injection method. Three batches MG1-MG3 were prepared in order to study influence of drug polymer ratio on the niosomes formation and in vitro drug release. The formulated niosomes were characterized by drug entrapment, vesicle size determination, and in vitro drug release. Optimized concentration of span 60 and cholesterol was found to be 1:1. In the in-vitro study, niosomes formulation of MG1 showed high percentage of drug release, 40.18 to 45.75% for about 8 hrs. This indicated that this batch of niosomes formulation exhibi

APA, Harvard, Vancouver, ISO, and other styles

28

Bodhankar, Shishupal S., and Mohini Sihare. "Formulation and Evaluation of Multiparticulate Pellet Systems for Antidiabetic and Antihypertensive Drugs: Application of Extrusion– Spheronization and Solution Layering Techniques." International Journal of Drug Delivery Technology 15, no. 02 (2025): 01–08. https://doi.org/10.25258/ijddt.15.2.10.

Full text

Abstract:

The present study focuses on the development and comprehensive evaluation of sustained and controlled release multiparticulate pellet formulations for three therapeutic agents: Tolbutamide, Saxagliptin, and Verapamil. The primary objective was to enhance drug release profiles and patient compliance using extrusion–spheronization and solution layering techniques. Tolbutamide and Verapamil were formulated into matrix-based sustained release pellets using hydrophilic polymers (HPMC) and plasticizers (MCC), while Saxagliptin pellets were prepared via solution layering on nonpareil seeds with optio

APA, Harvard, Vancouver, ISO, and other styles

29

Kotharapu, Rama Koteswararao, and Srinivas Lankalapalli. "Development and Evaluation of Clopidogrel Bisulphate Multi-Unit Floating Mini-Tablets." Journal of Drug Delivery and Therapeutics 9, no. 4 (2019): 173–80. http://dx.doi.org/10.22270/jddt.v9i4.3169.

Full text

Abstract:

The objective of the present work was to formulate and characterize multi-unit floating drug delivery system of Clopidogrel bisulphate to increase the bioavailability and sustain the drug release properties up to 8 h with more predictable drug release kinetics that avoids all or nothing emptying effect wherefore to improve patient compliance. Clopidogrel bisulphate floating mini-tablets were prepared by effervescent approach with melt granulation and direct compression techniques alone and in combination using Hydroxypropyl methylcellulose (HPMC) K100M and Compritol 888 ATO at different concen

APA, Harvard, Vancouver, ISO, and other styles

30

Reddy S, Giridhar. "Kinetic Studies for the Release of Hydroxychloroquine Sulphate Drug (HCQ) In-vitro in Simulated Gastric and Intestinal Medium from Sodium Alginate and Lignosulphonic Acid Blends." Trends in Sciences 20, no. 5 (2023): 5318. http://dx.doi.org/10.48048/tis.2023.5318.

Full text

Abstract:

Biodegradable polymeric blends are used to study the controlled release of Hydroxychloroquine sulphate (HCQ) as the model drug used extensively in COVID-19 treatments. HCQ drug is loaded in sodium alginate (NaAlg) and lignosulphonic acid (NaLS) blends as matrix are crosslinked using calcium chloride solution. Its release is evaluated in different pH mediums of simulated gastric fluid (SGF) and simulated intestinal fluid (SIF). The HCQ release data obtained during experimentation is used to study kinetics using different models to investigate polymeric relaxation's drug diffusion and mechanism

APA, Harvard, Vancouver, ISO, and other styles

31

Wang, Lei, and Gang Wu. "Local Delivery System Using Thermosensitive Hydrogel and Drug Loading Microspheres for Cartilage Repairing." Advanced Materials Research 898 (February 2014): 300–303. http://dx.doi.org/10.4028/www.scientific.net/amr.898.300.

Full text

Abstract:

A local drug delivery system constituted by hybrid microsphere/thermosensitive hydrogel was fabricated for Osteoarthritis (OA) therapy in the research. The hydrogel were synthesized by ring-opening copolymerization. Microsphere was fabricated by O/W emulsion and solution evaporation method. The properties of the products were characterized by 1HNMR, FTIR and phase transition diagram. The microsphere/hydrogel was prepared for in vitro drug release research. The results showed microsphere/hydrogel hybrid system can alleviate initial burst release. After 650 hours, only 60 percent of the drugs we

APA, Harvard, Vancouver, ISO, and other styles

32

Manalan, B. Valli, Nadendla Swathi, Narra Nandini, et al. "Formulate and evaluate once daily sustained release tablet of highly soluble drug of metformin HCL." International Journal of Research in Pharmaceutical Sciences and Technology 1, no. 4 (2020): 138–45. http://dx.doi.org/10.33974/ijrpst.v1i4.206.

Full text

Abstract:

The aim of the present study was to design an oral sustained release matrix tablet of highly water soluble biguanide anti diabetic drug. The matrix tablets are prepared by melt granulation method using HPMC K 200M as hydrophilic drug release retarding polymer, and stearic acid as melt able binder as well as hydrophobic carrier. The drug and excipients compatibility was studied by FT – IR. The formulated matrix tablets were characterized for physical parameters and in vitro dissolution profile. FT – IR spectra revealed the absence of drug excipients interaction. The physical parameters of the t

APA, Harvard, Vancouver, ISO, and other styles

33

Haidar, Ziyad S. "Mathematical Modeling for Pharmacokinetic Predictions from Controlled Drug Release Nano Systems: A Comparative Parametric Study." Biomedical and Pharmacology Journal 11, no. 4 (2018): 1801–6. http://dx.doi.org/10.13005/bpj/1552.

Full text

Abstract:

In the present work, several mathematical models well-known in the literature for simulating drug release kinetics are compared using available experimental data sets obtained in real systems with different drugs and nano-sized carriers. Herein, the χ2 minimization method, is employed concluding that the Korsmeyer-Peppas model provides the best-ﬁt in all cases. Hence, (i) better understanding of the exact mass transport mechanism(s) involved in drug(s) release, and (ii) quantitative prediction of the drug release kinetics, can be computed.

APA, Harvard, Vancouver, ISO, and other styles

34

Yin, Wang, Randy Bachelard Nziengui Raby, Yuankai Li, Zuojun Li, Mengqing Sun, and Zhi Huang. "An Alternating Magnetic Field-Controlled Drug Delivery System Based on 4,4′-Azobis (4-Cyanovaleric Acid)-Functioned Fe3O4@Chitosan Nanoparticles." Bioengineering 10, no. 2 (2023): 129. http://dx.doi.org/10.3390/bioengineering10020129.

Full text

Abstract:

Herein, we designed chitosan–coated Fe3O4 nanocomposites for the control release of drugs by an alternating magnetic field (AMF). The chitosan-coated Fe3O4 nanoparticles (Fe3O4@CS) were prepared by a alkaline co-precipitation method, and then, the model drug toluidine blue (TB) was covalently grafted onto the surface of the nanocomposite by a two-step amide reaction with the thermosensitive molecule 4,4′-azobis (4-cyanovaleric acid) (ACVA) as the linker group. The prepared nanocomposites were superparamagnetic and showed high magnetization saturation (about 54.0 emu g-1). In vitro hydrothermal

APA, Harvard, Vancouver, ISO, and other styles

35

Andreevskaya, SN, TG Smirnova, EN Antonov, et al. "New in vitro model to evaluate kinetics of antimycobacterial drug release from bioresorbable polymeric carriers." MicroRNA in ocular pathology, no. 2020(4) (August 2020): 10–15. http://dx.doi.org/10.24075/brsmu.2020.050.

Full text

Abstract:

Sustained-release drugs against tuberculosis are a promising approach to therapy since they positively affect patient compliance with long regimens, especially when it comes to the multidrug-resistant form of the disease. Conventional UV-visible spectroscopy does not work well with multicomponential culture media used for growing M. tuberculosis. The aim of this study was to develop a method for evaluating the kinetics of anti-tuberculosis drug released from bioresorbable polymeric carriers suitable for screening a wide range of encapsulated prolonged-release drugs and identifying the best per

APA, Harvard, Vancouver, ISO, and other styles

36

Joiner, Jordan B., Alka Prasher, Isabella C. Young, et al. "Effects of Drug Physicochemical Properties on In-Situ Forming Implant Polymer Degradation and Drug Release Kinetics." Pharmaceutics 14, no. 6 (2022): 1188. http://dx.doi.org/10.3390/pharmaceutics14061188.

Full text

Abstract:

In-situ forming implants (ISFIs) represent a simple, tunable, and biodegradable polymer-based platform for long-acting drug delivery. However, drugs with different physicochemical properties and physical states in the polymer-solvent system exhibit different drug release kinetics. Although a few limited studies have been performed attempting to elucidate these effects, a large, systematic study has not been performed until now. The purpose of this study was to characterize the in vitro drug release of 12 different small molecule drugs with differing logP and pKa values from ISFIs. Drug release

APA, Harvard, Vancouver, ISO, and other styles

37

Ghosal, Souvik, Javon E. Walker, and Christopher A. Alabi. "Predictive Platforms of Bond Cleavage and Drug Release Kinetics for Macromolecule–Drug Conjugates." Annual Review of Chemical and Biomolecular Engineering 12, no. 1 (2021): 241–61. http://dx.doi.org/10.1146/annurev-chembioeng-091720-030636.

Full text

Abstract:

Macromolecule–drug conjugates (MDCs) occupy a critical niche in modern pharmaceuticals that deals with the assembly and combination of a macromolecular carrier, a drug cargo, and a linker toward the creation of effective therapeutics. Macromolecular carriers such as synthetic biocompatible polymers and proteins are often exploited for their inherent ability to improve drug circulation, prevent off-target drug cytotoxicity, and widen the therapeutic index of drugs. One of the most significant challenges in MDC design involves tuning their drug release kinetics to achieve high spatiotemporal pre

APA, Harvard, Vancouver, ISO, and other styles

38

Afnan, Muhammad, Hamza Shakeel, Ghulam Mustafa, Waseem Akram, and Talib Husain. "Formulation, development and optimization of ofloxacin FDDS sustained release for UTI and H. pylori." Journal of Contemporary Pharmacy, Vol 8, (1) 2024 (June 30, 2024): 1–8. https://doi.org/10.56770/jcp2024811.

Full text

Abstract:

Objective: Development & Optimization of Ofloxacin Floating tablets to enhance gastric retention time. Sustained release effect of formulation will reduce the dosing frequency for UTIs and prolonged local effect will benefit against H-pylori infection. Materials: Pre formulation tests were performed which include bulk characteristics and flow properties. Post formulation studies include weight variation, thickness, content uniformity, hardness, friability, dissolution studies, release kinetics and compatibility & stability analysis. Kinetic studies were done and models were applied to

APA, Harvard, Vancouver, ISO, and other styles

39

Sharma, Megha, Seema Kohli, and Abhisek Pal. "PREPARATION AND EVALUATION OF CONTROLLED RELEASE FLOATING MICROSPHERES OF REPAGLINIDE: OPTIMIZATION AND IN-VITRO STUDIES." Asian Journal of Pharmaceutical and Clinical Research 10, no. 3 (2017): 103. http://dx.doi.org/10.22159/ajpcr.2017.v10i3.15310.

Full text

Abstract:

ABSTRACTObjective: To develop and evaluate floating microspheres of repaglinide (RG).Materials and Methods: RG loaded noneffervescent microspheres of different ratios of ethylcellulose (EC) and hydroxypropyl methylcellulose (HPMCK4M) were prepared using polyvinyl alcohol as emulsifier by solvent evaporation technique. Various process variables such as polymer ratio, stirringspeed, concentration of drug, and emulsifying agent were studied. Compatibility of drug and polymers was studied by Fourier-transform infraredspectroscopy (FTIR). Characterization, in-vitro evaluation, and kinetic studies w

APA, Harvard, Vancouver, ISO, and other styles

40

Vercik, Luci Cristina de Oliveira, Andres Vercik, and Eliana Cristina da Silva Rigo. "Kinetics of silver nanoparticle release from chitosan spheres." MRS Advances 2, no. 19-20 (2017): 1089–94. http://dx.doi.org/10.1557/adv.2017.48.

Full text

Abstract:

ABSTRACTThe kinetics of silver nanoparticles release from chitosan spheres is addressed experimentally and theoretically in this work. From the experimental viewpoint, the study of silver nanoparticles release is performed by measuring the time-dependent UV-Vis spectra of solutions where spheres were dispersed. The UV-VIS spectra intensity reflects the concentration of nanoparticles in the solution. Despite simple expressions for drug release are found in the literature, as those that relate the amount of drug release with the square root of time, a proper modeling might require the inclusion

APA, Harvard, Vancouver, ISO, and other styles

41

Suprianto, Suprianto. "ANALISIS KINETIKA PELEPASAN TEOFILIN DARI GRANUL MATRIKS KITOSAN." Jurnal Ilmiah Manuntung 2, no. 1 (2017): 70. http://dx.doi.org/10.51352/jim.v2i1.50.

Full text

Abstract:

Moment the drug dosage form development, it is important to study the drug release or dissolution that is recognized as an element in drug development. Mathematical models could help optimize the design of drugs to produce models of drug release information. Analysis of quantitative values obtained when depicting dissolution drug release profiles more easily when the mathematical concepts used to describe the drug release kinetics model. Model release of drugs known include zero order, first order, Higuchi models, models Hixon Crowell and Peppas Korsmeyer models. The purpose of this review app

APA, Harvard, Vancouver, ISO, and other styles

42

Posina Rakshitha, B. Deekshi Gladiola, and Cheepurupalli Prasad. "Formulation and biopharmaceutical evaluation of a transdermal patch containing letrozole." International Journal of Pharmaceuticals and Health Care Research 12, no. 4 (2024): 430–37. https://doi.org/10.61096/ijphr.v12.iss4.2024.430-437.

Full text

Abstract:

The skin can be used as the site for drug administration for continuous transdermal drug infusion into the systemic circulation. For the continuous diffusion penetration of the drugs through the intact skin surface membrane-moderated systems, matrix dispersion type systems, adhesive diffusion controlled systems and micro reservoir systems have been developed. Various penetration enhancers are used for the drug diffusion through skin. In matrix dispersion type systems, the drug is dispersed in the solvent along with the polymers and solvent allowed to evaporate forming a homogeneous drug-polyme

APA, Harvard, Vancouver, ISO, and other styles

43

Radu (Dușman), Ramona-Daniela, and Doina Drăgănescu. "Present and Future of ZrO2 Nanostructure as Reservoir for Drug Loading and Release." Coatings 13, no. 7 (2023): 1273. http://dx.doi.org/10.3390/coatings13071273.

Full text

Abstract:

Extensive research has been conducted on ZrO2 nanostructures due to their favorable biocompatibility, low toxicity, and promising prospects in various biomedical applications. They can be used as drug carriers, facilitating the administration of therapeutic substances into the body while enhancing their effectiveness and safety. This is achieved by regulating the timing, location, and rate at which drugs are released within the body. Several factors can influence the effectiveness of drug loading onto ZrO2 nanostructures, such as the physicochemical characteristics of the drugs, the surface pr

APA, Harvard, Vancouver, ISO, and other styles

44

Krueger, Bailey, Taylor Frazier, Sheila Galbreath, and Tarun Goswami. "Therapeutic efficacies of nano carriers and dissolution kinetics." Journal of Pharmaceutical and Biopharmaceutical Research 4, no. 2 (2022): 296–317. http://dx.doi.org/10.25082/jpbr.2022.02.002.

Full text

Abstract:

The drug dissolution behavior of poorly soluble medication such as doxorubicin has been conducted in this paper. Since the drug was fixed, different carriers used to deliver it and their dissolutions kinetics compiled from literature evaluated in this paper. Even though targeting of drugs is very important in drug delivery, it is not within the scope of this paper. However, functionalization of the carrier may provide this benefit, those constructs are included for comparison in terms of hybrid constructs. Dendrimer, micelles and hybrid constructs used in the delivery of doxorubicin compared i

APA, Harvard, Vancouver, ISO, and other styles

45

Ebadi, Mona, Kalaivani Buskaran, Bullo Saifullah, Sharida Fakurazi, and Mohd Zobir Hussein. "The Impact of Magnesium–Aluminum-Layered Double Hydroxide-Based Polyvinyl Alcohol Coated on Magnetite on the Preparation of Core-Shell Nanoparticles as a Drug Delivery Agent." International Journal of Molecular Sciences 20, no. 15 (2019): 3764. http://dx.doi.org/10.3390/ijms20153764.

Full text

Abstract:

One of the current developments in drug research is the controlled release formulation of drugs, which can be released in a controlled manner at a specific target in the body. Due to the diverse physical and chemical properties of various drugs, a smart drug delivery system is highly sought after. The present study aimed to develop a novel drug delivery system using magnetite nanoparticles as the core and coated with polyvinyl alcohol (PVA), a drug 5-fluorouracil (5FU) and Mg–Al-layered double hydroxide (MLDH) for the formation of FPVA-FU-MLDH nanoparticles. The existence of the coated nanopar

APA, Harvard, Vancouver, ISO, and other styles

46

Parashar, Tarun, Kapil Kalra, Jyoti M. Kalra, et al. "Formulation and In-vitro Evaluation of Bilayer Tablet of Olmesartan Medoxomil for Biphasic Drug Release." INTERNATIONAL JOURNAL OF PHARMACEUTICAL QUALITY ASSURANCE 14, no. 02 (2023): 388–92. http://dx.doi.org/10.25258/ijpqa.14.2.24.

Full text

Abstract:

Objective: The current study aimed to optimize the bioavailability and absorption of olmesartan in the lower gastrointestinal tract by creating a bilayer tablet for biphasic drug release. Methods: Microcrystalline cellulose was combined and direct compression the requirement for an early response to address an undesirable defect or condition. In the current instance, 5 mg of olmesartan must be released immediately, and the remaining 10 mg of olmesartan must be released gradually to maintain the therapeutic concentration. In order to adjust the release pattern of the olmesartan sustained releas

APA, Harvard, Vancouver, ISO, and other styles

47

Chandra, Prakash Sunuwar* Meenakshi Kandwal Shivanand Patil. "A Review on Formulation and Evaluation of Mirabegron Extended-Release Tablets." International Journal of Pharmaceutical Sciences 3, no. 5 (2025): 4859–65. https://doi.org/10.5281/zenodo.15547921.

Full text

Abstract:

A type of modified-release dosage form known as an extended-release (ER) tablet is designed to release the active pharmaceutical ingredient (API) gradually over a long period of time. The human body metabolizes and excretes drugs at different rates. Fast drug absorption may result in peak plasma concentrations that could be harmful, whereas fast clearance in conventional formulations causes subtherapeutic levels that necessitate frequent dose. Extended-release formulations get around these issues and ensure a long-lasting therapeutic effect by modifying the kinetics of medicine release. This s

APA, Harvard, Vancouver, ISO, and other styles

48

Damiri, Fouad, Yahya Bachra, Chaimaa Bounacir, Asmae Laaraibi, and Mohammed Berrada. "Synthesis and Characterization of Lyophilized Chitosan-Based Hydrogels Cross-Linked with Benzaldehyde for Controlled Drug Release." Journal of Chemistry 2020 (May 18, 2020): 1–10. http://dx.doi.org/10.1155/2020/8747639.

Full text

Abstract:

In this study, chitosan-based hydrogels were produced by incorporating three drugs with a different solubility into a polymer matrix. The lyophilized chitosan salt was prepared using an innovative and less-expensive synthetic process by the freeze-drying technique. Firstly, the three drugs (caffeine, ascorbic acid, and 5-fluorouracil (5-FU)) were selected as model drugs to test the in vitro release behavior of the hydrogel. The drugs were solubilized in chitosan salt, lyophilized, and cross-linked with benzaldehyde involving the formation of a Schiff base with (–C=N-) linkage to produce a phys

APA, Harvard, Vancouver, ISO, and other styles

49

G.Jagadeesh*, Dr.Vijaya Kuchana. "DESIGN AND INVITRO CHARACTERIZATION OF GASRO RETENTIVE MUCOADHESIVE FLOATING TABLETS OF METFORMIN HCL." Indo American Journal of Pharmaceutical Sciences 04, no. 09 (2017): 3202–9. https://doi.org/10.5281/zenodo.936410.

Full text

Abstract:

In the present research work gastro retentive mucoadhesive floating formulation of Metformin was developed by using various hydrophilic polymers. Initially analytical method development was done for the drug molecule. Absorption maxima was determined based on that calibration curve was developed by using different concentrations. Gas generating agent accrual and bioadhesive polymer carbopol concentration was optimized. Then the formulation was developed by using different concentrations of polymers of various polymers. The formulation blend was subjected to various preformualation studies, flo

APA, Harvard, Vancouver, ISO, and other styles

50

Kundrat, Vojtech, Nicole Cernekova, Adriana Kovalcik, Vojtech Enev, and Ivana Marova. "Drug Release Kinetics of Electrospun PHB Meshes." Materials 12, no. 12 (2019): 1924. http://dx.doi.org/10.3390/ma12121924.

Full text

Abstract:

Microbial poly(3-hydroxybutyrate) (PHB) has several advantages including its biocompatibility and ability to degrade in vivo and in vitro without toxic substances. This paper investigates the feasibility of electrospun PHB meshes serving as drug delivery systems. The morphology of the electrospun samples was modified by varying the concentration of PHB in solution and the solvent composition. Scanning electron microscopy of the electrospun PHB scaffolds revealed the formation of different morphologies including porous, filamentous/beaded and fiber structures. Levofloxacin was used as the model

APA, Harvard, Vancouver, ISO, and other styles

We offer discounts on all premium plans for authors whose works are included in thematic literature selections. Contact us to get a unique promo code!