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Journal articles on the topic 'Dynamic secondary metabolites'

Author: Grafiati

Published: 5 June 2025

Last updated: 2 August 2025

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1

METLEN, KERRY L., ERIK T. ASCHEHOUG, and RAGAN M. CALLAWAY. "Plant behavioural ecology: dynamic plasticity in secondary metabolites." Plant, Cell & Environment 32, no. 6 (2009): 641–53. http://dx.doi.org/10.1111/j.1365-3040.2008.01910.x.

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Danova, Kalina, and Laura Pistelli. "Plant Tissue Culture and Secondary Metabolites Production." Plants 11, no. 23 (2022): 3312. http://dx.doi.org/10.3390/plants11233312.

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Song, Chenxia, Yan Wang, Tao Sun, et al. "Annual Dynamic Changes in Lignin Synthesis Metabolites in Catalpa bungei ‘Jinsi’." Metabolites 15, no. 8 (2025): 493. https://doi.org/10.3390/metabo15080493.

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Background: Catalpa bungei ‘Jinsi’ has excellent wood properties and golden texture, which is widely used in producing furniture and crafts. The lignin content and structural composition often determine the use and value of wood. Hence, investigating the characteristics of the annual dynamics of lignin anabolic metabolites in C. bungei ‘Jinsi’ and analyzing their synthesis pathways are particularly important. Methods: We carried out targeted metabolomics analysis of lignin synthesis metabolites using ultra-performance liquid chromatography–tandem mass spectrometry (UPLC-MS/MS) on the xylem sam

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Wu, Zhaochen, Tuqiang Gao, Zhengya Liang, Jianjun Hao, Pengfei Liu, and Xili Liu. "Dynamic Changes in Plant Secondary Metabolites Induced by Botrytis cinerea Infection." Metabolites 13, no. 5 (2023): 654. http://dx.doi.org/10.3390/metabo13050654.

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In response to pathogen infection, some plants increase production of secondary metabolites, which not only enhance plant defense but also induce fungicide resistance, especially multidrug resistance (MDR) in the pathogen through preadaptation. To investigate the cause of MDR in Botrytis cinerea, grapes ‘Victoria’ (susceptible to B. cinerea) and ‘Shine Muscat’ (resistant to B. cinerea) were inoculated into seedling leaves with B. cinerea, followed by extraction of metabolites from the leaves on days 3, 6, and 9 after inoculation. The extract was analyzed using gas chromatography/quadrupole tim

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Yu, Yunxia, Zimin Wang, Dingmi Xiong, Liman Zhou, Fandong Kong, and Qi Wang. "New Secondary Metabolites of Mangrove-Associated Strains." Marine Drugs 22, no. 8 (2024): 372. http://dx.doi.org/10.3390/md22080372.

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Positioned at the dynamic interface between terrestrial and marine realms, mangroves embody a vibrant tapestry of biodiversity, encompassing an array of plants, animals, and microorganisms. These microbial inhabitants of mangrove habitats have emerged as a pivotal resource for antimicrobials and a plethora of pharmaceutically valuable compounds, spanning enzymes, antineoplastic agents, pesticides, immunosuppressants, and immunomodulators. This review delves into the recent landscape (January 2021 to May 2024, according to the time of publication) of novel secondary metabolites isolated from ma

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Seenivasan, R., M. Krishnamoorthy, and P. Velladurai. "Isolation, Screening and Biocidal Activity of Secondary Metabolites from Fungi of Paddy Field Soil Samples in Selected Alanganallur Sub Regions, Madurai, Tamil Nadu." International Journal of Research and Review 11, no. 8 (2024): 332–40. http://dx.doi.org/10.52403/jrr.20240835.

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Soil is a dynamic, living matrix that is an essential part of the terrestrial ecosystem. The soil serves as a reservoir for many microbial communities of plants and herbs which are producing, CO2 and nitrogen. Paddy (Oryza sativa L.) is the most important cereal crop of the world. Paddy field soil contains rich organic matters like old stubble, paddy straw, senescent roots and wastes. It also contains numerous types of fungi, which support rice production as well as maintain the fertility of paddy soil. This study investigates the secondary metabolites produced by various fungal species isolat

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Tallei, Trina, Fatimawali Fatimawali, Afriza Yelnetty, et al. "Unveiling the immunomodulatory mechanisms of pineapple metabolites: A multi-modal computational analysis using network pharmacology, molecular docking, and molecular dynamics simulation." Journal of Advanced Biotechnology and Experimental Therapeutics 7, no. 1 (2024): 1. http://dx.doi.org/10.5455/jabet.2024.d01.

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The exploration of the immunomodulatory potential of pineapple metabolites holds promise for substantial implications across several fields, encompassing medicine, pharmacology, nutrition, and public health. This study explores potential immune-regulating properties of secondary pineapple metabolites beyond bromelain, using computational techniques. Pineapple juice's secondary metabolites were identified via LC-MS-based metabolomics, selected using KNApSAcK Kanaya and Dr. Duke's databases. A heatmap was generated with Orange v.3.27.0. Bioactivity predictions utilized the PASS Online webserver,

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Ancheeva, Elena, Georgios Daletos, and Peter Proksch. "Bioactive Secondary Metabolites from Endophytic Fungi." Current Medicinal Chemistry 27, no. 11 (2020): 1836–54. http://dx.doi.org/10.2174/0929867326666190916144709.

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Background: Endophytes represent a complex community of microorganisms colonizing asymptomatically internal tissues of higher plants. Several reports have shown that endophytes enhance the fitness of their host plants by direct production of bioactive secondary metabolites, which are involved in protecting the host against herbivores and pathogenic microbes. In addition, it is increasingly apparent that endophytes are able to biosynthesize medicinally important “phytochemicals”, originally believed to be produced only by their host plants. Objective: The present review provides an overview of

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Akkaya, Hatice, and Aydın Özmaldar. "IN SILICO TRIAL APPROACHES BETWEEN PHYTOCHEMICAL COMPOSITION OF VERBENA OFFICINALIS AND LIVER CANCER TARGETS." Ankara Universitesi Eczacilik Fakultesi Dergisi 48, no. 3 (2024): 19. http://dx.doi.org/10.33483/jfpau.1417289.

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Objective: The abundance of bioactive metabolites in Verbena officinalis explains the biological benefits and folkloric use of the plant. Liver cancer is an extremely heterogeneous malignant disease compared to other defined tumors. To explore the potential therapeutic value of bioactive metabolites in Verbena officinalis, this study aimed to filter secondary metabolites, conduct ADME-Tox assessments, perform drug similarity tests, and analyze with molecular dynamic simulations. The objective was to evaluate how potential drug candidates derived from Verbena officinalis behave in biological sy

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Hectors, Kathleen, Sandra Van Oevelen, Jan Geuns, Yves Guisez, Marcel A. K. Jansen, and Els Prinsen. "Dynamic changes in plant secondary metabolites during UV acclimation inArabidopsis thaliana." Physiologia Plantarum 152, no. 2 (2014): 219–30. http://dx.doi.org/10.1111/ppl.12168.

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Pérez, Evelyn, Gretty Ettiene, Maribel Ramírez, and Ángel Gómez. "Phenology and environment in the presence of secondary metabolites in Psidium guajava L." Revista de la Facultad de Agronomía, Universidad del Zulia 40, Supplement (2023): e2340Spl04. http://dx.doi.org/10.47280/revfacagron(luz).v40.supl.04.

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Guava (Psidium guajava L.) is one of the most important fruit trees in Venezuela due to the acceptance of its fresh and processed fruit with relevant sensory and nutritional characteristics. The establishment of the crop in the producing areas has been the result of the initiative of leading farmers in the country. Due to the potential of guava, the present review aimed to describe the phenology, environment, and presence of secondary metabolites in P. guajava. The search for information on P. guajava included several key words such as phenology, flowering, fruiting, and secondary metabolism.

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Wang, Shuzhen, Feng He, Ruibin Hu, et al. "Dynamic Variation of Secondary Metabolites from Polygonatum cyrtonema Hua Rhizomes During Repeated Steaming–Drying Processes." Molecules 30, no. 9 (2025): 1923. https://doi.org/10.3390/molecules30091923.

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Polygonati Rhizoma, widely used as a traditional functional food and herbal medicine, is well known for its healthpromoting activities after the process of “nine cycles of steaming-drying”. Based on UPLC-MS/MS, 1369 secondary metabolites were identified in P. cyrtonema rhizomes, mainly alkaloids, amino acids and derivatives, flavonoids, organic acids, phenolic acids, and saccharides. The P. cyrtonema rhizomes were rich in xylose, arabinose, glucose, sorbose, mannose, galactose, rhamnose, inositol, fucose, sedoheptulose, phosphorylated monosaccharides, sugar acid, and sugar alcohols. Particular

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Colombo, Raffaella, Mayra Paolillo, and Adele Papetti. "A Dynamic In Vitro Model for Testing Intestinal Absorption of Different Vegetable Food Secondary Metabolites." Applied Sciences 13, no. 8 (2023): 5033. http://dx.doi.org/10.3390/app13085033.

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Cell-based bioreactors are important tools for evaluating molecule absorption in dynamic conditions, simulating simil-physiological flow, transport, and biological barriers. They allow for absorption and metabolization studies to be performed, obtaining very predictive data of in vivo conditions. In this paper, a new dynamic model is proposed to evaluate the intestinal absorption and toxicity of different vegetable food secondary metabolites, by using a LiveFlow® bioreactor. Different food secondary metabolites, such as caffeic, quinic, and rosmarinic acids, quercetin, and rutin, belonging to

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MITOI, Monica Elena, Alexandra Gabriela CIOCAN, Carmen Rodica MAXIMILIAN, Florenta Elena HELEPCIUC, and Gina Carmen COGALNICEANU. "BIOMASS AND VALUABLE METABOLITES DYNAMIC ACCUMULATION IN STRAWBERRY CALLUS CULTURES." AgroLife Scientific Journal 11, no. 2 (2022): 100–109. http://dx.doi.org/10.17930/agl2022213.

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Strawberry is one of the most commonly cultivated and consumed plant, due to its organoleptic properties and nutritional values, exerting multiple beneficial health effects. In this study, two distinct strawberry callus lines obtained in different lighting conditions were characterized. The biotechnological potential of these cultures can be demonstrated by biomass and secondary metabolites accumulation. For this reason, growth rate, cellular morphology and viability were assessed. For metabolic potential evaluation, biochemical analyses of total phenolic and flavonoid content, anthocyanin pig

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Perera, Pasindu Dilshan, and Haritha Lawan. "Antimicrobial Potential of Selected Phytochemicals from Hygrophila schulli; Computational Insights." Biology, Medicine, & Natural Product Chemistry 13, no. 1 (2024): 205–14. http://dx.doi.org/10.14421/biomedich.2024.131.205-214.

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The escalating global concern over antibiotic resistance has led to an intensified exploration of alternative therapeutic strategies, including the utilization of plant-derived secondary metabolites. In this in-silico study, we investigated the structural inhibition of bacterial DNA Topoisomerase IV complex by major secondary metabolites extracted from the medicinal plant Hygrophila schulli. The plant is renowned for its rich phytochemical composition, possessing bioactive compounds with diverse pharmacological properties. Using computational approaches, we conducted molecular docking simulati

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Wang, Yan, Ruixin Hao, Rongkun Guo, Huilan Nong, Yu Qin, and Ningguang Dong. "Integrative Analysis of Metabolome and Transcriptome Reveals Molecular Insight into Metabolomic Variations during Hawthorn Fruit Development." Metabolites 13, no. 3 (2023): 423. http://dx.doi.org/10.3390/metabo13030423.

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Hawthorn (Crataegus pinnatifida var. major), a cultivated fruit tree, is native and unique to China. Its fruits have high nutritional, health, and medicinal values. However, the development and ripening process of hawthorns is accompanied by dramatic changes in flavor, aroma, and bioactive phytochemicals, which are the fundamental factors that contribute to the potential health benefits and establishment of fruit quality. Therefore, an exploration of the dynamic changes in metabolites and their regulatory networks during the development of hawthorn fruits can elucidate the formation mechanisms

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Anwer, Eman K. E., Muhammad Ajagbe, Moustafa Sherif, et al. "Gut Microbiota Secondary Metabolites: Key Roles in GI Tract Cancers and Infectious Diseases." Biomedicines 13, no. 1 (2025): 100. https://doi.org/10.3390/biomedicines13010100.

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The gut microbiota, a dynamic ecosystem of trillions of microorganisms, produces secondary metabolites that profoundly influence host health. Recent research has highlighted the significant role of these metabolites, particularly short-chain fatty acids, indoles, and bile acids, in modulating immune responses, impacting epigenetic mechanisms, and contributing to disease processes. In gastrointestinal (GI) cancers such as colorectal, liver, and gastric cancer, microbial metabolites can drive tumorigenesis by promoting inflammation, DNA damage, and immune evasion. Conversely, these same metaboli

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Mishra, Ajay Kumar, Tomáš Kocábek, Vishnu Sukumari Nath, et al. "Dissection of Dynamic Transcriptome Landscape of Leaf, Bract, and Lupulin Gland in Hop (Humulus lupulus L.)." International Journal of Molecular Sciences 21, no. 1 (2019): 233. http://dx.doi.org/10.3390/ijms21010233.

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The hop plant (Humulus lupulus L.) produces several valuable secondary metabolites, such as prenylflavonoid, bitter acids, and essential oils. These compounds are biosynthesized in glandular trichomes (lupulin glands) endowed with pharmacological properties and widely implicated in the beer brewing industry. The present study is an attempt to generate exhaustive information of transcriptome dynamics and gene regulatory mechanisms involved in biosynthesis and regulation of these compounds, developmental changes including trichome development at three development stages, namely leaf, bract, and

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Sharma, Manoj Kumar. "Exploring the Biochemical Profiles of Medicinal Plants Cultivated Under Stressful Environmental Conditions." Current Agriculture Research Journal 12, no. 1 (2024): 81–103. http://dx.doi.org/10.12944/carj.12.1.07.

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The therapeutic potential of medicinal plants, attributed to diverse bioactive chemicals, is impacted by dynamic metabolic changes under environmental stressors such as salt, drought, and heavy metal exposure. This study aimed to elucidate the biochemical alterations in stressed medicinal plants and their implications for therapeutic qualities. Two groups of plants were compared: one cultivated in optimal conditions, serving as a control, and the other exposed to stressors mimicking real-world scenarios. Biochemical parameters, including total phenolic content, flavonoids, antioxidant activity

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Rossi, Tania, Daniele Vergara, Francesca Fanini, Michele Maffia, Sara Bravaccini, and Francesca Pirini. "Microbiota-Derived Metabolites in Tumor Progression and Metastasis." International Journal of Molecular Sciences 21, no. 16 (2020): 5786. http://dx.doi.org/10.3390/ijms21165786.

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Microbial communities and human cells, through a dynamic crosstalk, maintain a mutualistic relationship that contributes to the maintenance of cellular metabolism and of the immune and neuronal systems. This dialogue normally occurs through the production and regulation of hormonal intermediates, metabolites, secondary metabolites, proteins, and toxins. When the balance between host and microbiota is compromised, the dynamics of this relationship change, creating favorable conditions for the development of diseases, including cancers. Microbiome metabolites can be important modulators of the t

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Guo, Xiuchun, Zhaoyang Xia, Miaomiao Song, Changqin Li, Jinmei Wang, and Wenyi Kang. "Dynamic Changes of Secondary Metabolites and Antioxidant Activity of Ligustrum lucidum During Fruit Growth." Open Chemistry 16, no. 1 (2018): 99–107. http://dx.doi.org/10.1515/chem-2018-0012.

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AbstractThere are a number of secondary metabolites having medicinal values in Ligustri Lucidi Fructus. In this study, the target analytes salidroside, ligustroflavone, specnuezhenide, oleuropein, oleanolic acid and ursolic acid were chosen, aiming to establish a method to investigate the content of six compounds during eight growth stages of Ligustri Lucidi Fructus. Even though the results indicated that the contents of six compounds in different growth periods reached their maximum value, they displayed a downward trend. The antioxidant activity of the analyzed samples also decreased along w

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Belova, M. M., V. O. Shipunova, P. A. Kotelnikova, et al. "“Green” Synthesis of Cytotoxic Silver Nanoparticles Based on Secondary Metabolites of Lavandula Angustifolia Mill." Acta Naturae 11, no. 2 (2019): 47–53. http://dx.doi.org/10.32607/20758251-2019-11-2-47-53.

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In this study, we used green synthesis to prepare silver nanoparticles (NPs) from aqueous plant and callus extracts of the narrow-leaved lavender Lavandula angustifolia Mill. 35.4 1.6 nm and 56.4 2.4 nm nanoparticles, colloidally stable in phosphate-buffered saline, were synthesized using the plant extract and the callus extract, respectively. NPs were characterized by spectrophotometry, dynamic light scattering, and scanning electron microscopy. We studied the dynamics of the nanoparticle synthesis and evaluated the cytotoxic properties of the plant extract-based NPs. Modification of NPs with

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Sun, Ao, Guolong Liu, Luyan Sun, et al. "Study on the Dynamic Changes in Non-Volatile Metabolites of Rizhao Green Tea Based on Metabolomics." Molecules 28, no. 21 (2023): 7447. http://dx.doi.org/10.3390/molecules28217447.

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The processing of tea leaves plays a crucial role in the formation of the taste of the resulting tea. In order to study the compositions of and changes in taste-related substances during the processing of Rizhao green tea, non-targeted metabolomics was used, based on UHPLC-Q Exactive MS. Totals of 529, 349, and 206 non-volatile metabolites were identified using three different detection modes, of which 112 secondary metabolites were significantly changed. Significant variations in secondary metabolites were observed during processing, especially during the drying stage, and the conversion inte

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Filippini, Raffaella, Anna Piovan, Anna Borsarini, and Rosy Caniato. "Study of dynamic accumulation of secondary metabolites in three subspecies of Hypericum perforatum." Fitoterapia 81, no. 2 (2010): 115–19. http://dx.doi.org/10.1016/j.fitote.2009.08.002.

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Li, Shuai, Liangxuan Qi, Xinyang Tan, Shifang Li, Jichao Fang, and Rui Ji. "Small Brown Planthopper Nymph Infestation Regulates Plant Defenses by Affecting Secondary Metabolite Biosynthesis in Rice." International Journal of Molecular Sciences 24, no. 5 (2023): 4764. http://dx.doi.org/10.3390/ijms24054764.

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The small brown planthopper (SBPH, Laodelphax striatellus) is one of the most destructive insect pests in rice (Oryza sativa), which is the world’s major grain crop. The dynamic changes in the rice transcriptome and metabolome in response to planthopper female adult feeding and oviposition have been reported. However, the effects of nymph feeding remain unclear. In this study, we found that pre-infestation with SBPH nymphs increased the susceptibility of rice plants to SBPH infestation. We used a combination of broadly targeted metabolomic and transcriptomic studies to investigate the rice met

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Chen, Yu, Yihan Wu, Chao Wu, and Sizu Lin. "Comparative Analysis Reveals the Metabolic Characteristics of Astringent Seeds of Chinese Fir (Cunninghamia lanceolata (Lamb) Hook) during Astringent Compounds Accumulation Stages." Forests 11, no. 11 (2020): 1206. http://dx.doi.org/10.3390/f11111206.

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Research Highlights: The present study firstly reported the metabolic dynamics of astringent seed, a special type of abortion in Chinese fir, during the astringent material stages. The results provide a reference for further study on its occurrence mechanism and enrich the understanding of the plant seed developmental physiology. Background and Objectives: Astringent seed is a type of abortive phenomenon in Chinese fir, which significantly reduces the yield and quality of elite seeds for its high-incidence and indistinguishableness in seed orchard. Embryo defects can be observed in the astring

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Baldi, Sylvain, Pascale Bradesi, and Alain Muselli. "Guaianolide Derivatives from the Invasive Xanthium spinosum L.: Evaluation of Their Allelopathic Potential." Molecules 27, no. 21 (2022): 7297. http://dx.doi.org/10.3390/molecules27217297.

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Ziniolide, xantholide B (11α-dihydroziniolide), and 11β-dihydroziniolide, three sesquiterpene lactones with 12,8-guaianolide skeletons, were identified as volatile metabolites from the roots of Xanthium spinosum L., an invasive plant harvested in Corsica. Essential oil, as well as hydrosol and hexane extracts, showed the presence of guaianolide analogues. The study highlights an analytical strategy involving column chromatography, GC-FID, GC-MS, NMR (1D and 2D), and the hemi-synthesis approach, to identify compounds with incomplete or even missing spectral data from the literature. Among them,

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Yang, Lu, Shaoli Fan, Jiuyang Zhao, Jinfa Liao, Yicun Chen, and Yangdong Wang. "Comparative Metabolomics Revealed Differences in Alkaloids Metabolism Between Morus nigra L. and Morus. alba L. at Different Growth Stages." Journal of Biobased Materials and Bioenergy 18, no. 1 (2024): 64–72. http://dx.doi.org/10.1166/jbmb.2024.2347.

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Mulberry (Morus spp.), a flowering plant in the Moraceae family, is known for the edible fruit, and mulberry leaves have various applications. This experiment utilized ultra-high performance liquid chromatography-quadrupole time of flight mass spectrometry (UPLC-Q-TOF-MS) and Progenesis QI software to rapidly identify secondary metabolites in the leaves of Morus nigra L. and Morus alba L.. Orthogonal partial least squares discriminant analysis (OPLS-DA), principal component analysis (PCA) and Hierarchical clustering analysis (HCA) were used to examine the dynamic changes and stage specificity

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Md Nor, Shahidah, Phebe Ding, Faridah Abas, and Ahmed Mediani. "1H NMR Reveals Dynamic Changes of Primary Metabolites in Purple Passion Fruit (Passiflora edulis Sims) Juice during Maturation and Ripening." Agriculture 12, no. 2 (2022): 156. http://dx.doi.org/10.3390/agriculture12020156.

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Passion fruit (Passiflora edulis Sims) is a tropical fruit that shows an increasing demand from global fresh fruit industries. The fruit is known to have climacteric properties that allow it to achieve ripening during distribution and transportation. However, the metabolic alterations that occur during ripening are poorly understood. Thus, this study was conducted to analyze the metabolites in passion fruit juice at different harvesting stages (35, 42, 49, 56 and 63 days after anthesis), employing 1H NMR spectroscopy combined with chemometric analysis. A total of 30 metabolites were successful

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Mazhar, Muhammad Waqas, Muhammad Ishtiaq, Mehwish Maqbool, et al. "Synergistic effects of selenium nanoparticles and LED light on enhancement of secondary metabolites in sandalwood (Santalum album) plants through in-vitro callus culturing technique." PeerJ 12 (September 26, 2024): e18106. http://dx.doi.org/10.7717/peerj.18106.

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The yield and concentration of secondary metabolites (SMs) in plants can vary due to numerous challenges such as dynamic environmental conditions, moisture, soil quality, soil organic matter and plant genetics. To obtain a good yield of SMs novel elicitation approaches, such as the use of biotic and abiotic stressors, genetic modifications, and optimized growth conditions, have been practiced, particularly the use of selenium nanoparticles (SeNPs) and light emitting diode (LED) interaction through employing tissue culture technique. In the present study, in vitro callus cultures of sandalwood

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Tian, Xiaoming, Guangfeng Xiang, Cun Mou, et al. "Integrated Transcriptomic and Metabolomic Analysis Reveals Possible Molecular Mechanisms of Leaf Growth and Development in Disanthus cercidifolius var. longipes." Metabolites 14, no. 12 (2024): 654. http://dx.doi.org/10.3390/metabo14120654.

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Background: Disanthus cercidifolius var. longipes is an ancient relic plant unique to China. However, the typical shade-loving plant is largely exposed to the sun, which poses a major challenge to its conservation. Methods: This study explored dynamic changes in primary and secondary metabolites in D. cercidifolius leaves at different stages of development, combining metabolomics and transcriptome analysis to discuss the differentially accumulated metabolites (DAMs) and differentially expressed genes (DEGs). Results: The DAMs and DEGs were enriched in pathways related to photosynthesis, carbon

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Menaa, Farid, P. A. U. I. Wijesinghe, Gobika Thiripuranathar, et al. "Ecological and Industrial Implications of Dynamic Seaweed-Associated Microbiota Interactions." Marine Drugs 18, no. 12 (2020): 641. http://dx.doi.org/10.3390/md18120641.

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Seaweeds are broadly distributed and represent an important source of secondary metabolites (e.g., halogenated compounds, polyphenols) eliciting various pharmacological activities and playing a relevant ecological role in the anti-epibiosis. Importantly, host (as known as basibiont such as algae)–microbe (as known as epibiont such as bacteria) interaction (as known as halobiont) is a driving force for coevolution in the marine environment. Nevertheless, halobionts may be fundamental (harmless) or detrimental (harmful) to the functioning of the host. In addition to biotic factors, abiotic facto

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Soorya Aravindakshan, Aghil, Raghavendra L. S. Hallur, and Sameer Sharma. "In silico analysis of Trichosanthes lobata extracts: A promising source of antioxidants for therapeutic applications." Biomedicine 43, no. 3 (2023): 897–907. http://dx.doi.org/10.51248/.v43i3.2912.

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Introduction and Aim: Trichosanthes lobata is one of the species which belongs to Chinese traditional medicine for the therapeutic purpose of antioxidant properties. Free radicals’ production by the body has numerous beneficial roles including in immune systems, cellular signaling pathways, mitogenic response, and synthesis of cellular structures. This study aimed to evaluate the therapeutic efficacy of the T. lobata secondary metabolites toward COX proteins and validate their antioxidant potential. Materials and Methods: We extracted the plant using Soxhlet and subjected it to various assays

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Shen, Jianjun, Weiting Pu, Qiyan Song, et al. "Traditional Processing Can Enhance the Medicinal Effects of Polygonatum cyrtonema by Inducing Significant Chemical Changes in the Functional Components in Its Rhizomes." Pharmaceuticals 17, no. 8 (2024): 1074. http://dx.doi.org/10.3390/ph17081074.

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The aims of this study were to explore the significant chemical changes in functional components induced by the traditional processing method and evaluate whether this method based on nine cycles of steaming and drying can effectively enhance the medicinal effects of Polygonatum cyrtonema rhizome. A global analysis on dynamic changes in secondary metabolites during nine processing cycles was performed, and the significantly differentially accumulated secondary metabolites were initially identified based on the secondary metabolome. Unsupervised principal component analysis (PCA), hierarchical

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Phong, Nguyen Viet, Byung Sun Min, Seo Young Yang та Jeong Ah Kim. "Inhibitory Effect of Coumarins and Isocoumarins Isolated from the Stems and Branches of Acer mono Maxim. against Escherichia coli β-Glucuronidase". Applied Sciences 12, № 20 (2022): 10685. http://dx.doi.org/10.3390/app122010685.

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We isolated eight known secondary metabolites, including two isocoumarins and six coumarins, from the stems and branches of Acer mono Maxim. Their structures were confirmed using nuclear magnetic resonance spectroscopy and by comparing the data to published reports. The inhibitory effects of all compounds (1−8) on Escherichia coli β-glucuronidase were evaluated for the first time using in vitro assays. 3-(3,4-Dihydroxyphenyl)-8-hydroxyisocoumarin (1) displayed an inhibitory effect against β-glucuronidase (IC50 = 58.83 ± 1.36 μM). According to the findings of kinetic studies, compound 1 could f

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Legacki, Erin L., Elizabeth L. Scholtz, Barry A. Ball, Scott D. Stanley, Trish Berger, and Alan J. Conley. "The dynamic steroid landscape of equine pregnancy mapped by mass spectrometry." REPRODUCTION 151, no. 4 (2016): 421–30. http://dx.doi.org/10.1530/rep-15-0547.

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Liquid chromatography–tandem mass spectrometry (LC–MS/MS) allowed comprehensive analysis of various steroids detectable in plasma throughout equine gestation. Mares (n=9) were bled serially until they foaled. Certain steroids dominated the profile at different stages of gestation, clearly defining key physiological and developmental transitions. The period (weeks 6–20) coincident with equine chorionic gonadotropic (eCG) stimulation of primary corpora lutea and subsequent formation of secondary luteal structures was defined by increased progesterone, 17OH-progesterone and androstenedione, all Δ

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ZHANG, Ruizhen, Rong DUAN, Weiqing WANG, Zhiguo YU, Yun LI, and Yunli ZHAO. "Study on the dynamic variation of the secondary metabolites in Viscum coloratum using targeted metabolomics." Chinese Journal of Natural Medicines 21, no. 4 (2023): 308–20. http://dx.doi.org/10.1016/s1875-5364(23)60439-x.

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Rollando, Rollando, Melisa Dwi Chandra, Muhammad Hilmi Aftoni, and Windra Swastika. "Molecular Docking and Molecular Dynamic Studies of Secondary Metabolites from Momordica Charantia as Natural Antidiabetic." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 10, no. 1 (2024): 117–40. http://dx.doi.org/10.22487/j24428744.2024.v10.i1.15976.

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Background: Diabetes Mellitus is a non-contagious disease characterized by hyperglycemia. Diabetes mellitus occurs when the body cannot receive or use insulin properly. If you already have diabetes, then the patient must take medication continuously because diabetes mellitus is a lifelong disease. Because medicines are quite expensive, alternative ways to cure the disease are needed by consuming traditional medicines, one of which is bitter melon (Momordica charantia). Objectives: This research aims to predict the secondary metabolite compounds in the bitter melon plant, analyze molecular inte

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Eshananda, Yuriza, Sri Martina Wiraswati, Sri Lestari, Afifah Mariana, Tia Erfianti, and Hermin Pancasakti Kusumaningrum. "Ability of Secondary Metabolites from Actinomadura sp. as COVID-19 Protease Inhibitor: In Silico Method." Biotropic : The Journal of Tropical Biology 7, no. 2 (2023): 25–34. http://dx.doi.org/10.29080/biotropic.v7i2.1926.

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The pandemic of COVID-19 disease in the late of 2019 resulted in the massive screening for drug discovery purpose. However, there is still no reports about the ability of natural products from bacterial group of class Actinobacteria as COVID-19 inhibitor. The aim of this research is to identify the potential ability of natural compounds from Actinomadura sp., the member of class Actinobacteria, against two receptors of COVID-19 protease with PDB ID 6LU7 and 5R7Y. The eleven natural compounds were docked using AutoDock Vina and the interaction between receptor and ligands were analysed using LI

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Ibragić, Saida, Sabina Dahija, and Erna Karalija. "The Good, the Bad, and the Epigenetic: Stress-Induced Metabolite Regulation and Transgenerational Effects." Epigenomes 9, no. 2 (2025): 10. https://doi.org/10.3390/epigenomes9020010.

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Background: Plants face a wide range of environmental stresses that disrupt growth and productivity. To survive and adapt, they undergo complex metabolic reprogramming by redirecting carbon and nitrogen fluxes toward the biosynthesis of protective secondary metabolites such as phenylpropanoids, flavonoids, and lignin. Recent research has revealed that these stress-induced metabolic processes are tightly regulated by epigenetic mechanisms, including DNA methylation, histone modifications, chromatin remodeling, and non-coding RNAs. Methods: This review synthesizes current findings from studies o

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Zwetsloot, Alexander James, Gokhan Tut, and Anne Straube. "Measuring microtubule dynamics." Essays in Biochemistry 62, no. 6 (2018): 725–35. http://dx.doi.org/10.1042/ebc20180035.

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Microtubules are key players in cellular self-organization, acting as structural scaffolds, cellular highways, force generators and signalling platforms. Microtubules are polar filaments that undergo dynamic instability, i.e. transition between phases of growth and shrinkage. This allows microtubules to explore the inner space of the cell, generate pushing and pulling forces and remodel themselves into arrays with different geometry and function such as the mitotic spindle. To do this, eukaryotic cells employ an arsenal of regulatory proteins to control microtubule dynamics spatially and tempo

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Conte, Mariarosaria, Elisabetta Fontana, Angela Nebbioso, and Lucia Altucci. "Marine-Derived Secondary Metabolites as Promising Epigenetic Bio-Compounds for Anticancer Therapy." Marine Drugs 19, no. 1 (2020): 15. http://dx.doi.org/10.3390/md19010015.

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Sessile organisms such as seaweeds, corals, and sponges continuously adapt to both abiotic and biotic components of the ecosystem. This extremely complex and dynamic process often results in different forms of competition to ensure the maintenance of an ecological niche suitable for survival. A high percentage of marine species have evolved to synthesize biologically active molecules, termed secondary metabolites, as a defense mechanism against the external environment. These natural products and their derivatives may play modulatory roles in the epigenome and in disease-associated epigenetic

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Manefield, Mike, Diane McDougald, Scott A Rice, and Staffan Kjelleberg. "Bacterial communication: when does a metabolite become a signal?" Microbiology Australia 27, no. 3 (2006): 115. http://dx.doi.org/10.1071/ma06115.

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Bacterial communication has risen to prominence in microbiology as a dynamic research topic, both because of its role in microbial ecology and evolution and for the opportunity it offers to control pathogenic microbial activity. Bacterial communication has evolved from the metabolic processes of prokaryotic cellular life, in which the biosynthesis and breakdown of chemical compounds in central metabolism generates secondary metabolites with ambiguous utility in natural selection.

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Thiele Orberg, Erik, Elisabeth Meedt, Andreas Hiergeist, et al. "Bacterial and Bacteriophage Consortia Are Associated with Protective Intestinal Immuno-Modulatory Metabolites in Allogeneic Stem Cell Transplantation Patients." Blood 142, Supplement 1 (2023): 477. http://dx.doi.org/10.1182/blood-2023-172457.

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The human microbiome is a predictor of clinical outcome in patients undergoing allogeneic hematopoietic stem cell transplantation (allo-SCT). Besides bacteria, fungi and viruses as well as intestinal microbiota-derived metabolites are involved. However, it is still unclear how dynamic shifts in these three kingdoms contribute to the production of intestinal metabolites, how metabolites are impacted by graft-versus-host disease (GvHD) or antibiotics and whether they are associated with clinical outcome. We report the two-year follow-up of a prospective, observational, longitudinal cohort of all

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Patrick, Ryan M., Xing-Qi Huang, Natalia Dudareva, and Ying Li. "Dynamic histone acetylation in floral volatile synthesis and emission in petunia flowers." Journal of Experimental Botany 72, no. 10 (2021): 3704–22. http://dx.doi.org/10.1093/jxb/erab072.

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Abstract Biosynthesis of secondary metabolites relies on primary metabolic pathways to provide precursors, energy, and cofactors, thus requiring coordinated regulation of primary and secondary metabolic networks. However, to date, it remains largely unknown how this coordination is achieved. Using Petunia hybrida flowers, which emit high levels of phenylpropanoid/benzenoid volatile organic compounds (VOCs), we uncovered genome-wide dynamic deposition of histone H3 lysine 9 acetylation (H3K9ac) during anthesis as an underlying mechanism to coordinate primary and secondary metabolic networks. Th

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Zhu, Xiao-Mei, Xing-Xing Zhang, Run-Tan Cheng, et al. "Dynamical modelling of secondary metabolism and metabolic switches in Streptomyces xiamenensis 318." Royal Society Open Science 6, no. 4 (2019): 190418. http://dx.doi.org/10.1098/rsos.190418.

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The production of secondary metabolites, while important for bioengineering purposes, presents a paradox in itself. Though widely existing in plants and bacteria, they have no definite physiological roles. Yet in both native habitats and laboratories, their production appears robust and follows apparent metabolic switches. We show in this work that the enzyme-catalysed process may improve the metabolic stability of the cells. The latter can be responsible for the overall metabolic behaviours such as dynamic metabolic landscape, metabolic switches and robustness, which can in turn affect the ge

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Petelkov, Ivan, Vesela Shopska, Rositsa Denkova-Kostova, Kristina Ivanova, Georgi Kostov, and Velislava Lyubenova. "Investigation of Fermentation Regimes for the Production of Low-alcohol and Non-alcohol Beers." Periodica Polytechnica Chemical Engineering 65, no. 2 (2021): 229–37. http://dx.doi.org/10.3311/ppch.15975.

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The combination of modified mashing method and arrested fermentation for the production of low-alcohol and non-alcohol beers was studied. Therefore, five regimes for fermentation of wort with reduced fermentable sugar content with top-fermenting yeast strain at low temperatures and pitching rates were investigated. According to the fermentation dynamic results the decrease in the fermentation temperature from 10 °C to 5 °C at pitching rate of 109 Colony Forming Units cm−3 ( CFU cm−3 ) led to significantly reduced concentrations of ethanol and secondary metabolites in beer. The temperature decr

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Cui, Lili, Nan He, Xiaofeng Zhang, Shiming Li, Yan Zhang, and Wenyi Kang. "Dynamic Change of Secondary Metabolites and spectrum-effect relationship of Malus halliana Koehne flowers during blooming." Open Chemistry 16, no. 1 (2018): 362–70. http://dx.doi.org/10.1515/chem-2018-0043.

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AbstractMalus halliana Koehne flowers have been used as a Chinese traditional medicine to treat metrorrhagia. In this study, the dynamic changes in its secondary metabolites and spectrum-effect relationship of inhibition on α-glucosidase during blooming were investigated. The changes in the contents of three flavonoids (phloretin-4’-O-glycosidase, afzeloside, and 3-hydroxyphloridzin) were determined by high performance liquid chromatography (HPLC) and changes in inhibitory effect on α-glucosidase were evaluated in vitro. Then, spectrum-effect relationship was evaluated by partial least square

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Luo, Xuan, Jiahao Wu, Hongjuan Li, et al. "Integrative Analysis of Transcriptomic and Metabolomic Profiles Identifies Distinct Dynamic Changes in Primary and Secondary Metabolites in Grape Berries Under Fruit-Specific Light Exposure." Horticulturae 11, no. 5 (2025): 481. https://doi.org/10.3390/horticulturae11050481.

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Light influences fruit development and quality through two primary pathways: its effect on vegetative organs, which subsequently impacts the fruit, and its direct effect on the fruit itself. While the mechanism of the former pathway is well-documented, the direct impact of light on fruit has been less studied due to limitations in applying controlled light exposure to preharvest fruit. This study addresses this gap by developing a novel device that delivers fruit-specific light treatment, enabling precise light exposure without altering the light conditions of vegetative tissues. The integrati

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Maiti, Priyanka, Priyanka Sharma, Mahesha Nand, et al. "Integrated Machine Learning and Chemoinformatics-Based Screening of Mycotic Compounds against Kinesin Spindle ProteinEg5 for Lung Cancer Therapy." Molecules 27, no. 5 (2022): 1639. http://dx.doi.org/10.3390/molecules27051639.

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Among the various types of cancer, lung cancer is the second most-diagnosed cancer worldwide. The kinesin spindle protein, Eg5, is a vital protein behind bipolar mitotic spindle establishment and maintenance during mitosis. Eg5 has been reported to contribute to cancer cell migration and angiogenesis impairment and has no role in resting, non-dividing cells. Thus, it could be considered as a vital target against several cancers, such as renal cancer, lung cancer, urothelial carcinoma, prostate cancer, squamous cell carcinoma, etc. In recent years, fungal secondary metabolites from the Indian H

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