Academic literature on the topic 'Efutu'

This paper analyses the underlying themes in the songs and libation texts of the Aboakyer Festival of the Effutu in the Central Region of Ghana. The paper argues that the central theme and sub-themes of the songs and libation texts of the Aboakyer festival, reflect the worldview of the Effutu tribe of Ghana. The songs and libation texts reveal the Effutus as appreciative, religious, and haters of evil-doers.

This paper identified the great contribution of Flora Nwapa’s Efuru to ideas of ecological consciousness, and environmental protection, using theory that interlaces ecocriticism cum feminist criticism. The methodology therefore involves the conversation or ideas on the images of women and nature in ‘Efuru’, the association between the oppression of women and exploitation of nature by male chauvinist, thereby enslaving the female and nature in the commercial market value. From an ecofeminist perspective, this paper discovered that Flora Nwapa inculcates her novel with a theme of feminine and natural liberation from domination and violence. Flora Nwapa foresees the establishment of symbiosis, in which there is no male oppression or environment exploitation.Keywords: ecological conscience, male oppression, ecofeminism, domination, interconnectedness

Objective: To determine the opinion of the Efiks, Quas and Efuts of old Calabar district towards the practice of female circumcision. To examine the beliefs of the Efiks, Quas and Efuts of Calabar towards the practice of female circumcision. To determine the attitude of the Efiks, Quas and Efuts of Calabar towards the practice of female circumcision.Methods: In order to successfully carry out the study, three research questions and hypothesis were formulated. Literatures were reviewed based on the research variables. The research instrument used for data collection was questionnaire which was administered on three hundred and six (306) respondents who served as the sample for the study. Their responses were analyzed using frequencies, and percentages. Results showed that more than 50% are not in support of the practice and in fact more than 64% will not want their daughters circumcised.Results: It is observed that majority of educated, well informed and enlightened individuals who are aware of the harmful effects of the female circumcision abhors it. To this extent, proper education, and enlightenment, should be encouraged. Religions and cosmopolitan nature of the city are key to influencing the opinions, beliefs and attitude of the people living there. And finally, majority of the people think that the practice of female circumcision is decreasing in the city. Based on these findings information should continue to be disseminated using mass media and local languages for complete eradication and permanent attitudinal change.Conclusions: This work highlight the influence of public education and increase awareness from both the rural and urban communities so rooted to their cultures of female circumcision in old Calabar district as bad practice and unacceptable tradition in the 21st century world of today.

Background: Despite increasing prevalence of hyperglycemia leading to a type 2 diabetes mellitus (T2DM) in the urban areas, relatively little is known about its actual prevalence and associations in the rural population. This study sought to determine hyperglycemia and its associated risk factors among rural dwellers in the Effutu Municipality.Method: A simple-random cross-sectional study was conducted from January 2015 to May 2015 at the Effutu Municipality, in the Central region of Ghana. One hundred and forty-nine (149) participants were enrolled onto the study. A structured questionnaire was administered to obtain information on demography, alcohol use, tobacco use, educational status, visual challenges, sugary food intake and late-night eating. Blood samples were obtained for determination of fasting blood glucose (FBG). Body mass index (BMI), waist to hip ratio (WHR) and waist circumference (WC) were determined and hip circumference (HC) using standard protocols. Data obtained was analyzed with Statistical Package for Social Sciences (SPSS) and p < 0.05 was considered statistically significant.Results: The study showed 8.1% hyperglycemia among the rural dwellers and advanced age showed significant association with glycemic status (P = 0.0376). BMI, gender, waist hip ratio, waist circumference and hip circumference were higher in hyperglycemic participants than in normogylcaemic participants, however there was no significant difference when these parameters were compared by glycemic status.Conclusion: The prevalence of hyperglycemia in rural dwellers was 8.1% and it was significantly associated with advanced age. BMI, gender, HC, WC, WHR showed no association with hyperglycaemia.

This thesis presents a language-documentation-based description of aspects of the grammar of Efutu (Niger-Congo, Kwa, Southern-Guan), spoken in Winneba, a coastal town in the Central Region of Ghana, West Africa, by a group of fisherfolks. The thesis is in two parts. As the language is previously under-studied, the first part presents a general description of the basic phonology, morphology and syntax. Topics in the first part therefore include the sound system (vowels and consonants), tone, and some prominent phonological processes (vowel harmony, homorganic nasal assimilation); parts of speech; and tense, aspect, mood and negation. Part two focuses on serial verb constructions (SVCs), a prominent feature identified in the grammar of Efutu. SVCs from the documentation corpus are analysed using a set of criteria that help to classify them into groups. The methodology of such an analysis is considered to be data-driven. In addition to the data-driven methodology, a typological classification from Aikhenvald (2006) is adopted as a complementary approach to the analysis, especially, regarding the classification of SVCs. Various semantic types of SVCs, categorised as compositionally symmetrical or asymmetrical are identified and analysed. The means by which SVCs are used in expressing various meanings and functions in the grammar of the language are examined in some detail. Other properties of the SVCs, such as argument sharing and marking of grammatical categories, are also analysed. The documentation of the language mainly involves audio and video recordings of various speech and cultural events, as well as still photos and some texts, all generated through fieldwork totalling approximately fifteen months at three different stages. The recorded materials have been annotated (transcribed, translated, glossed, commented) in collaboration with native speakers in the field. The annotated corpus is then used as a basis for the description of the grammar of the language in this thesis.

Le royaume d'Efutu, un des principaux acteurs du commerce atlantique sur la cote de l'or aux XVIe et XVIIe siècles, s'efface de la scène commerciale à la fin du XVIIe siècle. Il disparait au XIXe siècle, au profit de l'état d'Oguaa (Cape Coast), crée au milieu du XVIIIe siècle par sécession de la ville d'Oguaa. Une étude des relations afro-européennes et des intermédiaires tente de fournir des explications à cette évolution. Au préalable sont étudiées la nature et les modalités des relations afro-européennes, et certaines de leurs conséquences , en particulier les acculturations réciproques. Les européens ne contrôlaient pas ces processus, comme en témoignent leurs échecs en matière d'évangélisation. En regard, la rapide diffusion des plantes américaines, effectuée à l'insu des européens, montre que les africains ne prirent chez les européens que ce qui les intéressait. Par ailleurs l'affaiblissement d'Efutu et la création de l'état d'Oguaa sont le fait d'évolutions internes de ces cosietes africaines, qui prennent place dans le cadre de la montée en puissance des grands états de l'intérieur et de la constitution de la confédération fanti. Efutu perdit sa prééminence commerciale et sa place politique en perdant le contrôle des intermédiaires commerciaux. Les grands intermédiaires commerciaux de Cape Coast ne sont plus, à la fin du XVIIe siècle, liés au lignage royal Efutu. Le grand courtier fanti nomme Brempong Kojo, qui fut à l'origine de la création de l'état d'Oguaa, entérinera définitivement ces évolutions et consacrera la disqualification politique et commerciale d'Efutu
The Efutu kingdom was one of the main actors of the Atlantic trade on the gold coast during the XVIth and XVIIth centuries. It disappeared from the commercial scene at the end of the XVIIth century, to the benefit of the Oguaa state (Cape Coast) created in the middle of the XVIIIth century by secessionof Oguaa town from Efutu. This study of the Afro-European relations and of the middle men between Africans and Europeans try to provide explanations to this evolution. We emphasize the nature and the mode of the afro-european relations, and some of their consequences, particularly the mutual acculturation. The material acculturation is the most obvious one. The europeans did not control this process, as can be seen by the failure of evangelisation. On the other hand, the quick diffusion of american plants shows that the Africans only took from the Europeans what they were interested in. The weakening of Efutu and the creation of Oguaa state do not seem to be due to the Europeans, but to some internal evolutions of these African societies. They took place in the context of the growth of hinterland states and of the constitution of fante confederation. By losing control of commercial middle men, efutu lost its commercial preeminence and its political position. At the end of the XVIIth century, the great fante trader called brempong kojo, who was at the root of the creation of Oguaa state, sealed the political and commercial disqualification of Efutu

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Este trabalho objetiva cartografar os efeitos de oficinas realizadas nas áreas da saúde mental, assistência social e arte-cultura. Entende-se o Oficinar como um dispositivo terapêutico e são pontuados, oportunamente, alguns modos, apostas e princípios referentes, modulações e experimentos que foram propostos desde o ano de 2006. Investiga-se as oficinas como um artifício na e da clínica a partir de uma perspectiva crítica dos processos e das relações que atravessam os jogos no Oficinar. O trabalho está dividido em três planos narrativos, possibilitando leituras independentes, muito embora elas se conectem em alguns encontros ao longo das explanações. O primeiro Narrativas Híbridas, traz uma descrição dos personagens conceituais Pedro Malasartes e Sebasthian Rodrigues. Ambos vivem e contam as histórias vivenciadas pelo autor por meio de cartas, fotos, poesias, músicas e relatos os efeitos possíveis nos processos e vivenciados em oficinas ocorridas num abrigo de população em situação de rua e numa ONG de educação não-formal. O segundo, Viagens no Recife, é um relato da experiência de imersão durante 30 dias na rede de atenção psicossocial (RAPS) do Recife pelo projeto Percursos formativos na RAPS: Intercâmbio entre experiências e supervisão clínico-institucional, do Ministério da saúde. Com a temática associada às demandas relacionadas ao álcool e a outras drogas, este plano traz algumas análises e problematizações no campo de atuação e de pesquisa-intervenção entre a RAPS do Recife e a RAPS de Vila Velha. No último, A Roda, enfatiza-se um ethos peculiar ao fazer alusão à roda de capoeira e à sua musicalidade e às linhas de subjetivações, o corpo no jogo desenvolvido no Oficinar a fim de mapear os elementos que compõem o que chamamos de O Oficinar numa ética da Vadiação, bem como traz narrativas do Oficinar num CAPS transtorno e num CAPS álcool e outras drogas. Ao final, Sebasthian traz fragmentos teóricos por uma Terapia Ocupacional tramada com as ferramentas conceituais da esquizoanálise.
The purpose of this paper was to map the effects of workshops related to mental health, social welfare and art/culture. Workshopping is understood as a therapeutic tool and some approaches, proposals and related principles, modifications and experiments proposed since 2006 were duly assessed. Workshopping was investigated as an instrument of and in clinics, from a critical perspective of the processes and relations underlying the workshop games. The study is divided into three narrative planes, which allow independent reading, but are linked by several interfaces along the explanations. The first plane, "Hybrid Narratives", provides a description of the conceptual characters Peter Malasartes and Sebasthian Rodrigues. Both tell experiences and stories by means of letters, pictures, poems, songs, and reports, expressing possible effects of processes and experiences in workshops in a homeless shelter and in a NGO for non-formal education. The second, the "Journey in Recife," is an account of an immersive experience of 30 days in the psychosocial care network (RAPS) of Recife/Pernambucco, in the framework of the Project “Training pathways in RAPS: interchange between experience and clinical-institutional supervision”, of the Ministry of Health. As the subject is associated with demands related to alcohol and other drugs, this plane presents some analyses and problem statements in the field of intervention measures and research, focused on the RAPS Recife/Pernambucco and RAPS Vila Velha/Espirito Santo. Finally, in "The Circle", a peculiar ethnic element is addressed, which is the capoeira circle with its musicality and lines of subjectivation, emphasizing the body in games developed in workshops, to map the elements of what we call " Workshopping in an ethic of idleness". In narrative descriptions, workshops at a "Psychosocial Care Center (CAPS) for mental disorder" and a CAPS for alcohol and other drugs are highlighted. At the end, Sebasthian adds theoretical fragments of an Occupational Therapy plotted with conceptual tools of schizoanalysis.

To be or not to be that is the question. The Church's Understanding of Death and the Dead with reference to the traditional Effutu people's beliefs and practices is an attempt to do theology in an African way as well as to understand the Christian Faith in terms of death and the dead. In the pervasive influence and challenge of the Christian message to Africans, Effutus not excepted, and demand upon their individual lives and their relationships with one another; in countless personal and group decisions made, and lives actually lived very differently from what they would otherwise have been, in the new high hopes and aspirations for individual and social destiny which it has awakened; in the sheer excellence of human performance in devotion and courageous, self-sacrificing service to others, and yet in other ways, Christianity still plays a role and exerts a force in the Effutu Traditional Area in particular and Ghanaians' way of life in general. This is none the less real and significant because Christianity eludes full and conclusive analysis. For instance, questions relating to the understanding of death; funeral rites; the relationship between the living and the dead - all have been issues of tension between African and the west. As a result there is widespread readiness today to repudiate the missionary past by the Africans who for more than a century now, have been doing theology regarding death and the dead in a strange language, in strange thought forms, in a strange ideology. African theology and especially that of death and the dead is at the crossroad. In some sense it finds some 'natural' affinities with Liberation Theology and historically, as far as Christ's death is concerned, could be connected with western theology. Yet, while it may and should attempt to draw from the richness of both theologies, African theology of the dead should guard against capitulating to either of those forms. It must be dynamic, ready to change and address itself to all situations in time and space. It should be liberating, freeing mankind from all chains, including social, racial, economic, cultural, and even confessional domination. In short, the primary concern of African theology and especially that of death and the dead must be the proclamation and 'incarnation' of the message that "Now we no longer believe because of what you told us; we have heard him ourselves and we know that he really is the Saviour of the world" (John 4/42), through his suffering and death, wrath 'and judgement - all working on behalf of man and his reconciliation.

This study investigated how much influence the SES of parents has on students’ achievements in the Awutu-Senya and Effutu Educational Directorates of the Central Region of Ghana. The study focused on parents’ financial status, educational qualifications, jobs, enabling learning environment provided by parents and the type of school attended and how these affected students’ achievements. The study adopted a cross sectional and a multi-site case study designs. The population consisted of school officials, teachers, students of SHS and parents in the Awutu Senya and Effutu Educational Districts in the Central Region of Ghana. A sample size of 531 respondents was chosen for the study. The instruments used in the data collection were questionnaires, semi-structured interviews, focus group discussions, direct observation and secondary data. A range of sampling techniques from simple random, purposive, census, to cluster sampling techniques was adopted in selecting the participants. The researcher used descriptive and inferential statistics in presenting the data. Respondents agreed that parents’ financial circumstances affected students’ academic achievements in the study area. Respondents were of the opinion that learning environment provided by parents at home determined the academic achievements of students. The study found that students from high socio-economic homes were provided with most of the materials they needed to succeed in their education than their counterparts. Respondents agreed to some extent with the assumption that educational qualifications of parents influenced students’ academic success. They argued that parents’ educational attainments enhanced home environment for students’ learning. The study made original contributions by highlighting parents’ financial difficulties they faced in promoting their children’s education, isolating some of the influences of SES of parents on students’ learning and providing policy implications. The study recommends that Government of Ghana should expand its youth training programme on skills acquisition to cover all categories of people who desire skills.

Les bacteries halophiles extremes vivent dans des milieux ultrasalins tels les marais salans et la mer morte. Les facteurs d'elongation tu, proteine qui interagit avec des aminocyl-trna, chez halobacterium marismortui a ete etudie, a ete purifie et ses proprietes halophiles demontrees, et la purification du gene codant pour cette monomolecule a ete realisee

Introducción: Pseudomonas aeruginosa es un patógeno oportunista que causa una gran variedad de infecciones, entre las que destacan las infecciones respiratorias agudas y crónicas y las infecciones de heridas por quemaduras. En un trabajo previo, usamos anticuerpos específicos para detectar la presencia del epítopo de fosforilcolina en la superficie bacteriana asociado al factor de elongación Tu (EF-Tu). Identificamos que el gen eftM (Elongation Factor Tu Modifying enzime) es el responsable de la incorporación de fosforilcolina a EF-Tu. Además demostramos que este epítopo es crucial para la colonización inicial del tracto respiratorio por P. aeruginosa y el desarrollo de neumonía. En esta tesis hemos investigado la contribución de la fosforilcolina en la interacción de P. aeruginosa con los queratinocitos epidérmicos humanos y en las infecciones de heridas por quemadura causadas por este patógeno. Contenido de la investigación: La proteína EF-Tu recombinante purificada de un aislado clínico y de un mutante isogénico desprovisto del gen eftM funcional fue analizada por espectrometría de masas. El análisis comparativo demostró que el producto de eftM es una metiltransferasa (EftM) que incorpora tres grupos metilo al residuo 5 de lisina de EF-Tu dando lugar a un epítopo estructuralmente igual a la fosforilcolina. Mediante la combinación de técnicas de fraccionamiento celular, microscopía electrónica e inmunología, demostramos que EftM trimetila EF-Tu en el citoplasma, el cual es posteriormente transportado a la membrana externa, dejando el residuo 5 trimetilado expuesto hacia el exterior. Los ensayos de invasión y transmigración con cultivos de queratinocitos humanos polarizados infectados con la cepa parental o el mutante en eftM demostraron que la trimetilación de EF-Tu media la migración de P. aeruginosa a través de la barrera epitelial. Esto es debido a que la cepa parental es capaz de alterar, de forma más eficiente que el mutante, la permeabilidad de la barrera epitelial mediante la reducción de la expresión de ZO-1, una proteína clave para la integridad del epitelio. Los ensayos con un antagonista del receptor del factor activador de plaquetas (PAFR) demostraron que este receptor media la interacción de P. aeruginosa con los queratinocitos a través de EF-Tu trimetilado. Sin embargo, la reducción de ZO-1 no es debida directamente a la interacción EF-Tu-PAFR, sino que está inducida por la activación, por parte de P. aeruginosa, del factor de transcripción celular NF-κB. Finalmente, los experimentos en un modelo murino de infección por quemadura demostraron que la mutación de eftM reduce notablemente la virulencia y la capacidad de diseminación de P. aeruginosa. Conclusiones: Se ha identificado el gen eftM, que codifica una nueva metiltransferasa que incorpora tres grupos metilo al residuo 5 de lisina de EF-Tu. EftM está muy conservado y ampliamente distribuido entre especies y es necesario y suficiente para metilar EF-Tu en P. aeruginosa o en otros sistemas heterólogos. EF-Tu está en la membrana externa exponiendo la región N-terminal trimetilada hacia el exterior. Dicha trimetilación facilita la invasión y transmigración bacteriana a través de queratinocitos humanos mediante la interacción con PAFR. P. aeruginosa reduce los niveles de proteína ZO-1 incrementando la permeabilidad paracelular de la barrera epitelial, proceso mediado por la activación de NF-κB. La carencia de EftM reduce la virulencia de P. aeruginosa en un modelo murino de infección de quemadura. La nueva metiltransferasa podría ser una nueva diana para el diseño de fármacos contra P. aeruginosa.
Introducció: Pseudomonas aeruginosa és un patogen oportunista que causa una gran varietat d’infeccions, entre les quals destaquen les infeccions respiratòries agudes i cròniques i les infeccions de ferides per cremada. A un treball previ, vàrem utilitzar anticossos específics per detectar la presència de l’epítop de fosforilcolina a la superfície del bacteri associat al factor d’elongació Tu (EF-Tu). Vàrem identificar que el gen eftM (Elongation Factor Tu Modifying enzime) és el responsable de la incorporació de fosforilcolina a EF-Tu. A més a més demostrarem que aquest epítop és clau per la colonització inicial del tracte respiratori per P. aeruginosa i el desenvolupament de pneumònia. En aquesta tesi hem investigat la contribució de la fosforilcolina a la interacció de P. aeruginosa amb els queratinocits epidèrmics humans i a les infeccions de ferides per cremades causades per aquest patogen. Contingut de la recerca: La proteïna EF-Tu recombinant purificada d’un aïllament clínic i d’un mutant isogènic desproveït del gen eftM funcional va ser analitzat per espectrometria de masses. L’anàlisi comparativa va demostrar que el producte de eftM és una metiltranferasa (EftM) que incorpora tres grups metil al residu 5 de lisina de EF-Tu donant lloc a un epítop estructuralment igual a la fosforilcolina. Mitjançant la combinació de tècniques de fraccionament cel·lular, microscopia electrònica i immunologia, hem demostrat que EftM trimetila EF-Tu al citoplasma, el qual és posteriorment transportat a la membrana externa, deixant el residu 5 trimetilat expossat cap a l’exterior. Els assajos d’invasió i transmigració amb cultius de queratinocits humans polaritzats infectats amb la soca parental o el mutant d’eftM demostraren que la trimetilació d’ EF-Tu facilita la migración de P. aeruginosa a través de la barrera epitelial. Això és degut al fet que la soca parental és capaç d’alterar, de forma més eficient que el mutant, la permeabilitat de la barrera epitelial mitjançant la reducció de l’expressió de ZO-1, una proteïna clau per a la integritat de l’epiteli. Els assajos amb un antagonista del receptor del factor activador de plaquetes (PAFR) demostraren que aquest receptor actua com a intermediari en la interacció de P. aeruginosa amb els queratinòcits a través d’EF-Tu trimetilat. No obstant això, la reducció de ZO-1 no és deguda directament a la interacció EF-Tu-PAFR, sino que està induïda per l’activació, per part de P. aeruginosa, del factor de transcripció cel·lular NF-κB. Finalment, els experiments a un model murí d’infecció per cremada demostraren que la mutació d’eftM redueix la virulència i la capacitat de disseminació de P. aeruginosa. Conclusions: S’ha identificat el gen eftM, que codifica una nova metiltransferasa que incorpora tres grups metil al residu 5 de lisina d’EF-Tu. EftM està molt conservat i àmpliament distribuït entre espècies i és necessari i suficient per metilar EF-Tu a P. aeruginosa o a altres sistemes heteròlegs. EF-Tu està a la membrana externa exposant la regió N-terminal trimetilada cap a l’exterior. Aquesta trimetilació facilita la invasió i transmigració bacteriana a través de queratinocits humans mitjançant la interacció amb PAFR. P. aeruginosa redueix els nivells de proteïna ZO-1, incrementant la permeabilitat paracel·lular de la barrera epitelial, procés mitjançat per l’activació de NF-κB. La mancança d´EftM redueix la virulència de P. aeruginosa a un model murí d’infecció de cremada. La nova metiltransferasa podria ser una nova diana pel disseny de fàrmacs contra P. aeruginosa.
Introduction: Pseudomonas aeruginosa is an opportunistic pathogen responsible of a wide range of infections including acute and chronic respiratory infections and wound burn infections. In a previous study, we used specific antibodies to detect the presence of the phosphorylcholine epitope on the bacterial surface linked to the elongation factor Tu (EF-Tu). We identified the gene eftM (Elongation Factor Tu Modifying enzime) as the responsible of the modification of EF-Tu with phosphorylcholine. In addition, we demonstrated that this epitope is crucial for initial colonization of the respiratory tract by P. aeruginosa and for development of pneumonia. In this Thesis we have investigated the contribution of the phosphorylcholine in the interaction of P. aeruginosa with the human epidermic keratinocytes and in the burn wound infections caused by this pathogen. Research: A tandem mass spectrometry analysis was choosen to compare recombinant EF-Tu purified from a clinical isolate and from an isogenic eftM deficient mutant. Comparative analysis shown that the product of eftM, is a methyltransferase (EftM) that transfers three methyl groups to the lysine residue 5 of EF-Tu resulting in a chemical structure similar to phosphorylcholine. Through a combination of approaches, including sub-cellular fractionation, electronic microscopy and immunological techniques, we demonstrated that EftM trymethylates EF-Tu in the cytoplasm, which is subsequently transported to the outer membrane, leaving the trimethylated residue 5 exposed outwards. Invasion and transmigration experiments with cultured human polarized keratinocytes infected with the wild-type strain or the eftM mutant demonstrated that the trimethylation of EF-Tu mediates the migration of P. aeruginosa through the epithelial barrier. Accordingly, the wild-type strain increased the paracellular permeability and reduced the expression of ZO-1, a key protein for the integrity of the epithelial barrier, more efficiently than the mutant. An antagonist of the platelet activating factor receptor (PAFR) reduced the invasion and transmigration of the wild type strain but had no effect on the mutant suggesting that PAFR on the keratinocytes mediates the interaction with the modified EF-Tu. However, reduction of ZO-1 is not directly due to the interaction EF-Tu-PAFR, but is due to the activation of the transcription factor NF-κB induced by P. aeruginosa. Finally, we demonstrated the mutation of eftM impaired the virulence and the dissemination capacity of P. aeruginosa in murine model of wound burn infection. Conclusions: We have identified the gen eftM, encoding a novel methyltransferase, which links three methyl groups to the lysine residue 5 of EF-Tu. EftM is conserved and widely distributed among different species and is sufficient and necessary to methylate EF-Tu in P. aeruginosa and other heterologous systems. EF-Tu is on the outer membrane exposing the N-terminal trimethylated region outward. Trimethylation of EF-Tu promotes invasion and transmigration of the microorganisms via PAFR. Activation of NF-κB by P. aeruginosa induces the reduction of ZO-1 and increase the paracellular permeability of the epithelial barrier. Mutation of eftM reduces the virulence of P. aeruginosa in a murine model of wound burn infection. This opens up new avenues for the development of new drugs targeting this new methyltransferase.