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Journal articles on the topic 'Ellagic acid derivatives'

Author: Grafiati
Published: 5 June 2025
Last updated: 1 August 2025

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1

Simões-Pires, Claudia A., Sandra Vargas, Andrew Marston, et al. "Ellagic Acid Derivatives from Syzygium cumini Stem Bark: Investigation of their Antiplasmodial Activity." Natural Product Communications 4, no. 10 (2009): 1934578X0900401. http://dx.doi.org/10.1177/1934578x0900401012.

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Bioguided fractionation of Syzygium cumini (Myrtaceae) bark decoction for antiplasmodial activity was performed, leading to the isolation of three known ellagic acid derivatives (ellagic acid, ellagic acid 4-O-α-L-2″-acetylrhamnopyranoside, 3-O-methylellagic acid 3′-O-α-L-rhamnopyranoside), as well as the new derivative 3-O-methylellagic acid 3′-O-β-D-glucopyranoside. Activity investigation was based on the reduction of P. falciparum (PfK1) parasitaemia in vitro and the inhibition of β-hematin formation, a known mechanism of action of some antimalarial drugs. Among the investigated ellagic aci
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2

Sullim Lee, Et al. "In Silico Screening of Ellagic Acid Derivatives and Their Metabolites as Inhibitors for NF-?b and Tnf?" International Journal on Recent and Innovation Trends in Computing and Communication 11, no. 9 (2023): 3160–65. http://dx.doi.org/10.17762/ijritcc.v11i9.9465.

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The aim of this study was to evaluate inhibitory effects of ellagic acid derivatives and their metabolites on tumor necrosis factor ? (TNF?) and nuclear factor-?B (NF-?B). In silico molecular docking was performed. 3-O-methyl-3', 4' -methylenedioxy ellagic acid (MMDEA) and urolithin D were to be potent inhibitors of TNF? among tested molecules. For NF-?B (p50 and p65 subunits), MMDEA was found to be a potent inhibitor comparable with tanshinone IIA, a known NF-?B inhibitor. Ellagic acid derivatives seemed to be more effective than urolithins, their metabolites. All of the ellagic acid derivati
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3

Tadzhibav, M. M., É. Kh Batirov, A. D. Vdovin, V. M. Malikov, K. L. Lutfullin, and M. R. Yagudaev. "Ellagic acid derivatives fromEuphorbia ferganensis." Chemistry of Natural Compounds 23, no. 5 (1987): 630–31. http://dx.doi.org/10.1007/bf00598694.

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4

Choi, Young-Hee, John Pezzuto, A. Kinghorn, and Norman Farnsworth. "Ellagic Acid Derivatives ofAgrostistachys hookeri1." Planta Medica 54, no. 06 (1988): 511–13. http://dx.doi.org/10.1055/s-2006-962532.

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5

Filho, Wilson Wolter, Arnaldo I. Da Rocha, Massayoshi Yoshida, and Otto R. Gottlieb. "Ellagic acid derivatives from Rhabdodendron macrophyllum." Phytochemistry 24, no. 9 (1985): 1991–93. http://dx.doi.org/10.1016/s0031-9422(00)83107-6.

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6

Li, Xing-Cong, Hala N. Elsohly, Charles D. Hufford, and Alice M. Clark. "NMR assignments of ellagic acid derivatives." Magnetic Resonance in Chemistry 37, no. 11 (1999): 856–59. http://dx.doi.org/10.1002/(sici)1097-458x(199911)37:11<856::aid-mrc529>3.0.co;2-x.

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7

Djoukeng, Jules Desire, Eliane Abou-Mansour, Leon Azefack Tapondjou, David Lontsi, and Raffaele Tabacchi. "Identification of Ellagic Acid Derivatives from Stem Bark of Syzygium Guineense (Myrtaceae)." Natural Product Communications 2, no. 3 (2007): 1934578X0700200. http://dx.doi.org/10.1177/1934578x0700200307.

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An LC-DAD-ESI-MSn technique was developed to investigate crude extracts of the stem bark of S. guineense for phenolic compounds. Ellagic acids were detected on the basis of their UV absorption spectra and ESI-MS fragmentation patterns. Six ellagic acid conjugates in the complex extract of S. guineense were identified. With the aim to confirm the structures, further purification of the extract afforded the known 3-O-ellagic acid-4′-O-α-rhampyranonosides (3), two new ellagic acid rhamnopyranosides, 3-O-methylellagic acid-4′-O-α-2″-O-acetylrhamnopyranoside (4) and 3-O-methylellagic acid-4′-O-α-3″
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8

Xu, Ya-ming, Jing-Zhen Deng, Ji Ma, et al. "DNA damaging activity of ellagic acid derivatives." Bioorganic & Medicinal Chemistry 11, no. 7 (2003): 1593–96. http://dx.doi.org/10.1016/s0968-0896(02)00452-2.

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9

Heur, Young-Hun, Wenguang Zeng, Gary D. Stoner, Gregory A. Nemeth, and Bruce Hilton. "Synthesis of Ellagic Acid O-Alkyl Derivatives and Isolation of Ellagic Acid as a Tetrahexanoyl Derivative from Fragaria ananassa." Journal of Natural Products 55, no. 10 (1992): 1402–7. http://dx.doi.org/10.1021/np50088a003.

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10

Salih, Enass Y. A., Riitta Julkunen-Tiitto, Olavi Luukkanen, Marketta Sipi, Mustafa K. M. Fahmi, and Pia Johanna Fyhrquist. "Potential Anti-Tuberculosis Activity of the Extracts and Their Active Components of Anogeissus leiocarpa (DC.) Guill. and Perr. with Special Emphasis on Polyphenols." Antibiotics 9, no. 7 (2020): 364. http://dx.doi.org/10.3390/antibiotics9070364.

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In Sudanese traditional medicine, decoctions of the stem bark of Anogeissus leiocarpa are used for the treatment of tuberculosis (TB). However, this plant has not been investigated before for its antimycobacterial effects. Our screening results show, for the first time, that many extracts of various parts of A. leiocarpa exhibit growth inhibitory activity against Mycobacterium smegmatis. Minimum inhibitory concentration (MIC) values ranged between 625 and 5000 µg/mL, with an ethyl acetate extract of the root showing the lowest MIC value. The good antimycobacterial effects of the root part coul
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11

Tsouri, Steliana, Evanthia Tselo, Georgios E. Premetis, et al. "A Monocarbonyl Curcuminoid Derivative Inhibits the Activity of Human Glutathione Transferase A4-4 and Chemosensitizes Glioblastoma Cells to Temozolomide." Pharmaceuticals 17, no. 3 (2024): 365. http://dx.doi.org/10.3390/ph17030365.

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Human glutathione transferase A4-4 (hGSTA4-4) displays high catalytic efficiency towards 4-hydroxyalkenals and other cytotoxic and mutagenic products of radical reactions and lipid peroxidation. Its role as a target for the chemosensitization of cancer cells has not been investigated so far. In this study, the inhibitory potency of twelve selected natural products and ten monocarbonyl curcumin derivatives against hGSTA4-4 was studied. Among natural products, ellagic acid turned out to be the strongest inhibitor with an IC50 value of 0.44 ± 0.01 μM. Kinetic analysis using glutathione (GSH) and
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12

Weidner-Wells, Michele A., Jason Altom, Jeffrey Fernandez, et al. "DNA gyrase inhibitory activity of ellagic acid derivatives." Bioorganic & Medicinal Chemistry Letters 8, no. 1 (1998): 97–100. http://dx.doi.org/10.1016/s0960-894x(97)10197-4.

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13

Tchetan, Esaïe, Sergio Ortiz, Pascal Abiodoun Olounladé, et al. "Fractionation Coupled to Molecular Networking: Towards Identification of Anthelmintic Molecules in Terminalia leiocarpa (DC.) Baill." Molecules 28, no. 1 (2022): 76. http://dx.doi.org/10.3390/molecules28010076.

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Terminalia leiocarpa is a medicinal plant widely used in ethnoveterinary medicine to treat digestive parasitosis whose extracts were shown to be active against gastrointestinal nematodes of domestic ruminants. The objective of our study was to identify compounds responsible for this activity. Column fractionation was performed, and the activity of the fractions was assessed in vitro on Haemonchus contortus and Caenorhabditis elegans as well as their cytotoxicity on WI38 fibroblasts. Two fractions were the most active on both nematode models and less cytotoxic. LC-MS/MS analysis and manual dere
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14

Грибова, Н. А., and И. Б. Перова. "Influence of processing methods of strawberries on the content of ellagic acid derivatives." Food processing industry, no. 2 (January 25, 2024): 16–19. http://dx.doi.org/10.52653/ppi.2024.2.2.003.

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В свежих ягодах и в продуктах их переработки содержится высокая концентрация полезных для здоровья фенольных соединений. Особенно среди фенольных соединений выделяют эллаговую кислоту, которая обладает сильными антиоксидантными, противовоспалительными и противоаллергическими свойствами. Эллаговая кислота является водорастворимым антиоксидантом из класса полифенолов, относящаяся к гидроксибензойной кислоте. Фенольная кислота оказывает антиканцерогенное действие, предотвращает развитие раковых клеток, обладает кровоостанавливающим, противовоспалительным, антимикробным свойствами, это естественны
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15

Machumi, Francis, Jacob O. Midiwo, Melissa R. Jacob, et al. "Phytochemical, Antimicrobial and Antiplasmodial Investigations of Terminalia brownii." Natural Product Communications 8, no. 6 (2013): 1934578X1300800. http://dx.doi.org/10.1177/1934578x1300800619.

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Phytochemical investigation of the ethyl acetate-soluble fraction of stem bark extract of an African medicinal plant Terminalia brownii led to the isolation of a new oleanane-type triterpenoid, along with seven known triterpenoids, seven ellagic acid derivatives, and 3- O-β-D-glucopyranosyl-β-sitosterol. The new compound was identified using spectroscopic methods, notably 1D- and 2D NMR, as 3β,24- O-ethylidenyl-2α,19α-dihydroxyolean-12-en-28-oic acid. The isolated compounds were evaluated for their antimicrobial and antiplasmodial activities. Two compounds with a galloyl group (4 and 6) were f
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16

Tokutomi, Hisashi, JianYun Wu, Takashi Takeda, Norihisa Hoshino, and Tomoyuki Akutagawa. "Phase transition and molecular assembly structure of ellagic acid ester derivatives." New Journal of Chemistry 42, no. 18 (2018): 14700–14703. http://dx.doi.org/10.1039/c8nj02609b.

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17

Guo, Sen, Xiameng Ren, Kan He, et al. "The anti-diabetic effect of eight Lagerstroemia speciosa leaf extracts based on the contents of ellagitannins and ellagic acid derivatives." Food & Function 11, no. 2 (2020): 1560–71. http://dx.doi.org/10.1039/c9fo03091c.

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18

Tabopda, Turibio Kuiate, Joseph Ngoupayo, Jia Wei Liu, et al. "Induction of Neuronal Differentiation in Neurosphere Stem Cells by Ellagic Acid Derivatives." Natural Product Communications 4, no. 4 (2009): 1934578X0900400. http://dx.doi.org/10.1177/1934578x0900400415.

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A bioassay-guided fractionation of methanol extracts of stem barks, combined with screening based on Epidermal Growth Factor (EGF)-responsive neural stem cells (erNSCs) differentiation assay, has been used. This study resulted in the isolation of 3,3′-di- O-methylellagic acid 1, 3,3′-di- O-methyl ellagic acid-4- O-β-D-xylopyranoside 2, ellagic acid 3, and arjunolic acid 4. Among them, compounds 1 and 2 exhibit potent induction of neuronal differentiation in neurosphere stem cells with no cytotoxic effect. These results indicate that compounds 1 and 2 may be useful as pharmacological agents for
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19

Ito, A. "Ellagic acid derivatives and cytotoxic cucurbitacins from Elaeocarpus mastersii." Phytochemistry 61, no. 2 (2002): 171–74. http://dx.doi.org/10.1016/s0031-9422(02)00232-7.

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20

Singh, Awantika, Vikas Bajpai, Sunil Kumar, Kulwant Rai Sharma, and Brijesh Kumar. "Profiling of Gallic and Ellagic Acid Derivatives in Different Plant Parts of Terminalia Arjuna by HPLC-ESI-QTOF-MS/MS." Natural Product Communications 11, no. 2 (2016): 1934578X1601100. http://dx.doi.org/10.1177/1934578x1601100227.

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Terminalia arjuna is a medicinal plant used in ethnomedicine and the codified traditional medicine. A number of active constituents are reported, but there is no information on the whole range of gallic and ellagic acid derivatives present in this plant. A rapid and sensitive analytical method was developed using reverse phase high-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry (HPLC-ESI-QTOF-MS/MS) for qualitative analysis to determine the array of bioactive phytochemicals and their variations in different plant parts viz. bark, unripe fruit, ripe f
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21

Feunaing, Romeo Toko, Alfred Ngenge Tamfu, Abel Joel Yaya Gbaweng, et al. "In Vitro and Molecular Docking Evaluation of the Anticholinesterase and Antidiabetic Effects of Compounds from Terminalia macroptera Guill. & Perr. (Combretaceae)." Molecules 29, no. 11 (2024): 2456. http://dx.doi.org/10.3390/molecules29112456.

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Alzheimer’s disease (AD) and diabetes are non-communicable diseases with global impacts. Inhibitors of acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) are suitable therapies for AD, while α-amylase and α-glucosidase inhibitors are employed as antidiabetic agents. Compounds were isolated from the medicinal plant Terminalia macroptera and evaluated for their AChE, BChE, α-amylase, and α-glucosidase inhibitions. From 1H and 13C NMR data, the compounds were identified as 3,3′-di-O-methyl ellagic acid (1), 3,3′,4′-tri-O-methyl ellagic acid-4-O-β-D-xylopyranoside (2), 3,3′,4′-tri-O-meth
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22

Saadullah, Malik, Muhammad Asif, Abdul Sattar, et al. "Cytotoxic and antioxidant potentials of ellagic acid derivatives from Conocarpus lancifolius (Combretaceae)." Tropical Journal of Pharmaceutical Research 19, no. 5 (2020): 1037–80. http://dx.doi.org/10.4314/tjpr.v19i5.24.

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Purpose: Isolation, characterisation and structure elucidation of compounds obtained from Conocarpus lancifolius and screening of their pharmacological effects in vitro.Methods: After collection, authentication and extraction from whole C. lancifolius plants, screening for secondary metabolites, thin-layer chromatography and subsequent open column chromatography were performed for phytochemical analysis and subsequent purification of the compounds. The chemical structures of the isolated compounds were elucidated using spectroscopic (UV-visible, infrared and mass) spectroscopy, and nuclear mag
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23

Różyło, Renata, Ryszard Amarowicz, Michał Adam Janiak, et al. "Micronized Powder of Raspberry Pomace as a Source of Bioactive Compounds." Molecules 28, no. 12 (2023): 4871. http://dx.doi.org/10.3390/molecules28124871.

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Red raspberries, which contain a variety of nutrients and phytochemicals that are beneficial for human health, can be utilized as a raw material in the creation of several supplements. This research suggests micronized powder of raspberry pomace production. The molecular characteristics (FTIR), sugar, and biological potential (phenolic compounds and antioxidant activity) of micronized raspberry powders were investigated. FTIR spectroscopy results revealed spectral changes in the ranges with maxima at ~1720, 1635, and 1326, as well as intensity changes in practically the entire spectral range a
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24

Karczmarz, Katarzyna, Agnieszka Szmagara, and Elżbieta Anna Stefaniak. "ELLAGIC ACID CONTENT IN SELECTED WILD SPECIES OF FRUIT ROSES." Acta Scientiarum Polonorum Hortorum Cultus 18, no. 5 (2019): 131–40. http://dx.doi.org/10.24326/asphc.2019.5.13.

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Ellagic acid (EA) is a natural antioxidant, belonging to the group of polyphenolic compounds. It displays a broad spectrum of pro-health effects, ranging from the prevention of cancer to antiviral properties. It is present in many fruit from the rose family (Rosaceae): strawberries, raspberries, blackberries and walnuts as well as cranberries and grapes. The available literature states that the fruit of roses, in addition to their aesthetic and functional applications, also show therapeutic properties, which, among other things, are associated with a high content of polyphenols, including ella
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25

Atta-Ur-Rahman, F. N. Ngounou, M. Iqbal Choudhary, et al. "New Antioxidant and Antimicrobial Ellagic Acid Derivatives from Pteleopsis hylodendron." Planta Medica 67, no. 4 (2001): 335–39. http://dx.doi.org/10.1055/s-2001-14306.

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26

Ye, Guan, Hua Peng, Mingsong Fan, and Cheng-Gang Huang. "Ellagic acid derivatives from the stem bark of Dipentodon sinicus." Chemistry of Natural Compounds 43, no. 2 (2007): 125–27. http://dx.doi.org/10.1007/s10600-007-0060-y.

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27

Soh, René F., Jean K. Bankeu, Bruno N. Lenta, et al. "Antibacterial Ellagic Acid Derivatives and Other Constituents from Pancovia pedicellaris." Zeitschrift für Naturforschung B 64, no. 9 (2009): 1070–76. http://dx.doi.org/10.1515/znb-2009-0913.

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Two new ellagic acid derivatives, named panconosides A (1) andB(2) were isolated from Pancovia pedicellaris together with eleven known compounds (3 - 13). The structures of 1 and 2, as well as those of the known compounds were established by spectroscopic methods and by comparison with previously reported data. Compounds 1 and 2 were tested in vitro for their antibacterial potential against six strains of microorganisms: Micrococcus luteus, Streptococcus ferus, Streptococcus minor, Escherichia coli, Bacillus subtilis, and Pseudomonas agarici. They were found to exhibit moderate antibacterial a
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28

WEIDNER-WELLS, M. A., J. ALTOM, J. FERNANDEZ, et al. "ChemInform Abstract: DNA Gyrase Inhibitory Activity of Ellagic Acid Derivatives." ChemInform 29, no. 18 (2010): no. http://dx.doi.org/10.1002/chin.199818280.

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29

Bindra, R. S., N. K. Satti, and O. P. Suri. "Isolation and structures of ellagic acid derivatives from Euphorbia acaulis." Phytochemistry 27, no. 7 (1988): 2313–15. http://dx.doi.org/10.1016/0031-9422(88)80150-x.

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30

Cho, Hyunnho, Hana Jung, Heejae Lee, Hae Chang Yi, Ho-kyung Kwak, and Keum Taek Hwang. "Chemopreventive activity of ellagitannins and their derivatives from black raspberry seeds on HT-29 colon cancer cells." Food & Function 6, no. 5 (2015): 1675–83. http://dx.doi.org/10.1039/c5fo00274e.

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31

Nasser, Ana L. M., Camila B. A. Carli, Clenilson M. Rodrigues, et al. "Identification of Ellagic Acid Derivatives in Methanolic Extracts from Qualea Species." Zeitschrift für Naturforschung C 63, no. 11-12 (2008): 794–800. http://dx.doi.org/10.1515/znc-2008-11-1203.

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Abstract The methanolic extract from the barks of the medicinal plant Qualea parviflora (Vochysiaceae) was fractionated by column chromatography over silica gel followed by gel permeation over Sephadex LH-20 to give 3,3′-di-O-methylellagic acid-4-O-β-d-glucopyranoside (1), 3-Omethylellagic acid-4′-O-α-l-rhamnopyranoside (2), 3,3′,4-tri-O-methylellagic acid-4′-O-β-dglucopyranoside (3), and 3,3′-di-O-methylellagic acid (4), together with triterpenes and saponins. We also performed comparative analyses among this species and Q. grandiflora and Q. multiflora using high-pressure liquid chromatograp
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32

Zheng, Yan-Zhen, Zhong-Min Fu, Geng Deng, Rui Guo, and Da-Fu Chen. "Free radical scavenging potency of ellagic acid and its derivatives in multiple H /e processes." Phytochemistry 180 (December 31, 2020): 1–9. https://doi.org/10.1016/j.phytochem.2020.112517.

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Zheng, Yan-Zhen, Fu, Zhong-Min, Deng, Geng, Guo, Rui, Chen, Da-Fu (2020): Free radical scavenging potency of ellagic acid and its derivatives in multiple H /e processes. Phytochemistry (112517) 180: 1-9, DOI: 10.1016/j.phytochem.2020.112517, URL: http://dx.doi.org/10.1016/j.phytochem.2020.112517
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Djedjibegovic, Jasmina, Aleksandra Marjanovic, Emiliano Panieri, and Luciano Saso. "Ellagic Acid-Derived Urolithins as Modulators of Oxidative Stress." Oxidative Medicine and Cellular Longevity 2020 (July 28, 2020): 1–15. http://dx.doi.org/10.1155/2020/5194508.

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Oxidative stress is a state of excess of prooxidative species relative to the antioxidant defenses (enzymatic and nonenzymatic) in a living organism. The consequence of this imbalance is damage of the major cellular macromolecules (carbohydrates, lipids, proteins, and DNA), which further leads to a gradual loss of tissue and organ function. It has been shown that oxidative stress plays an important role in the pathogenesis of many chronic diseases (cardiovascular, metabolic, and neurodegenerative diseases and cancer) and in the process of aging. Thus, many strategies to combat oxidative stress
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34

Gagić, Tanja, Željko Knez, and Mojca Škerget. "Subcritical Water Extraction of Chestnut Bark and Optimization of Process Parameters." Molecules 25, no. 12 (2020): 2774. http://dx.doi.org/10.3390/molecules25122774.

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The aim of the work was the optimization of the subcritical water extraction process of chestnut bark using Box–Behnken response surface methodology. The influence of process parameters, such as temperature, extraction time and solvent-solid ratio, on extraction yield, yield of the main compounds, total phenol content, total tannin content and antioxidant activity has been investigated. The identified compounds were ellagic and gallic acids, ellagitannins (vescalagin, castalagin, 1-o-galloyl castalagin, vescalin and castalin), sugars (maltose, glucose, fructose and arabinose) and sugar derivat
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35

Cerulli, Antonietta, Assunta Napolitano, Milena Masullo, Cosimo Pizza, and Sonia Piacente. "LC-ESI/LTQOrbitrap/MS/MSn Analysis Reveals Diarylheptanoids and Flavonol O-glycosides in Fresh and Roasted Hazelnut (Corylus avellana cultivar “Tonda di Giffoni”)." Natural Product Communications 13, no. 9 (2018): 1934578X1801300. http://dx.doi.org/10.1177/1934578x1801300906.

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Hazelnut represents one of the most consumed food, containing a large range of bioactive and health-promoting compounds. Investigation of the fatty component of C. avellana nut has been widely carried out, but little is known about its phenolic content. In order to achieve deeper insight into the polar fraction of the n-butanol extracts of both fresh and roasted kernels of C. avellana cultivar, “Tonda di Giffoni” a PGI (Protected Geographical Indication) product of Campania region (Italy), a phytochemical investigation was carried out. High performance liquid chromatography coupled to electros
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Kaczmarek-Szczepańska, Beata, Sylwia Grabska-Zielińska, and Marta Michalska-Sionkowska. "The Application of Phenolic Acids in The Obtainment of Packaging Materials Based on Polymers—A Review." Foods 12, no. 6 (2023): 1343. http://dx.doi.org/10.3390/foods12061343.

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This article provides a summarization of present knowledge on the fabrication and characterization of polymeric food packaging materials that can be an alternative to synthetic ones. The review aimed to explore different studies related to the use of phenolic acids as cross-linkers, as well as bioactive additives, to the polymer-based materials upon their application as packaging. This article further discusses additives such as benzoic acid derivatives (sinapic acid, gallic acid, and ellagic acid) and cinnamic acid derivatives (p-coumaric acid, caffeic acid, and ferulic acid). These phenolic
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37

Santos, Klebson Silva, Ana Letícia Sirqueira Nascimento, Andriele Mendonça Barbosa, et al. "Cambuí (Myrciaria floribunda (West ex Willd.) O. Berg): A potential nutritional supplement for inhibition of COVID-19 infections / Cambuí (Myrciaria floribunda (West ex Willd.) O. Berg): Um potencial suplemento nutricional para a inibição de infecções por COVID-19." Brazilian Journal of Development 8, no. 2 (2022): 11975–87. http://dx.doi.org/10.34117/bjdv8n2-235.

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In the present study, we suggest that the Myrciaria floribunda (West ex Willd.) O. Berg fruit (cambuí) is a natural source of potential molecules against COVID-19. Extracts from orange and purple cambuí were obtained by using pressurized hot water extraction (PHWE). Extraction overall yield was 39.66 ± 1.62% and 33.00 ± 8.44% for the extracts of purple and orange cambuí, respectively. All analyzed extracts showed high total phenolic contents, especially those of purple fruits (3870.37 ± 353.09 mg GAE/100g). The total flavonoid content was 693.16 ± 180.09 and 770.08 ± 103.62 mg RE/100g for purp
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38

Tang, Long, Jianchun Jiang, Guoqiang Song, et al. "Design, Synthesis, and Biological Evaluation of Novel 6H-Benzo[c]chromen-6-one Derivatives as Potential Phosphodiesterase II Inhibitors." International Journal of Molecular Sciences 22, no. 11 (2021): 5680. http://dx.doi.org/10.3390/ijms22115680.

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Urolithins (hydroxylated 6H-benzo[c]chromen-6-ones) are the main bioavailable metabolites of ellagic acid (EA), which was shown to be a cognitive enhancer in the treatment of neurodegenerative diseases. As part of this research, a series of alkoxylated 6H-benzo[c]chromen-6-one derivatives were designed and synthesized. Furthermore, their biological activities were evaluated as potential PDE2 inhibitors, and the alkoxylated 6H-benzo[c]chromen-6-one derivative 1f was found to have the optimal inhibitory potential (IC50: 3.67 ± 0.47 μM). It also exhibited comparable activity in comparison to that
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39

Nguyen Lam Hong, Nguyen Thi Hue, Nguyen Thuy Linh, Pham Van Cuong, and Doan Thi Mai Huong. "CHEMICAL CONSTITUENTS FROM THE STEMS OF CLEISTANTHUS EBERHARDTII." Tạp chí Dược liệu 30, no. 2 (2025): 74–79. https://doi.org/10.63240/jmm-nimm.2025.2.106.

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From the stems of Cleistanthus eberhardtii (Gagnep.) Croizat, nine known compounds were isolated, including two triterpenoids (lupeol (1) and betulinic acid (2)), one ellagic acid derivative (3,3′-di-O-methylellagic acid-4′-O-α-L-rhamnopyranoside (3)), one steroid (β-sitostenone (4)), and five benzoic acid derivatives (2,3-dihydroxy-1-(4′-hydroxy-3-methoxyphenyl)propane-1-one (5), 3,4-dihydroxybenzaldehyde (6), 3,4-dihydrobenzoic acid (7), methyl 3,4-dihydroxybenzoate (8), and methyl gallate (9). The structures of these compounds were determined through MS and NMR spectra analyses and comparis
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Wojtunik-Kulesza, Karolina, Przemysław Niziński, Anna Krajewska, Tomasz Oniszczuk, Maciej Combrzyński, and Anna Oniszczuk. "Therapeutic Potential of Ellagic Acid in Liver Diseases." Molecules 30, no. 12 (2025): 2596. https://doi.org/10.3390/molecules30122596.

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Ellagic acid (EA) is a natural polyphenol found in various fruits, nuts, and mushrooms. It exhibits a variety of biological activities, including potent antioxidant, anti-inflammatory, anti-obesity, and neuroprotective properties. EA exerts hepatoprotective effects through multiple mechanisms, including (1) scavenging reactive oxygen species (ROS) and enhancing endogenous antioxidant defenses (e.g., by activating Nrf2/ARE), (2) modulating inflammatory signaling pathways (e.g., inhibiting NF-κB, TNF-α, and IL-6), and (3) regulating apoptosis (e.g., downregulating the Bax/Bcl-2 ratio) and fibros
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41

Díaz-de-Cerio, Elixabet, Vito Verardo, Ana María Gómez-Caravaca, Alberto Fernández-Gutiérrez, and Antonio Segura-Carretero. "Determination of Polar Compounds in Guava Leaves Infusions and Ultrasound Aqueous Extract by HPLC-ESI-MS." Journal of Chemistry 2015 (2015): 1–9. http://dx.doi.org/10.1155/2015/250919.

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Literature lacks publications about polar compounds content in infusion or guava leaves tea. Because of that, a comparison between different times of infusion and a conventional ultrasound aqueous extract was carried out. Several polar compounds have been identified by HPLC-ESI-MS and their antioxidant activity was evaluated by FRAP and ABTS assays. Four different classes of phenolic compounds (gallic and ellagic acid derivatives, flavonols, flavanones, and flavan-3-ols) and some benzophenones were determined. The quantification results reported that the order, in terms of concentration of the
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42

Rose, Kenneth, Chunpeng Wan, Amber Thomas, Navindra P. Seeram, and Hang Ma. "Phenolic Compounds Isolated and Identified from Amla (Phyllanthus emblica) Juice Powder and their Antioxidant and Neuroprotective Activities." Natural Product Communications 13, no. 10 (2018): 1934578X1801301. http://dx.doi.org/10.1177/1934578x1801301019.

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The edible fruit of Phyllanthus emblica (known as amla and Indian gooseberry) is widely used in Eastern traditional medicinal systems for a variety of ailments. Our group has previously reported that an amla juice powder shows neuroprotective effects in several in vitro and in vivo assay models but its chemical constituents and their neuroprotective activity remain unknown. Therefore, we conducted a phytochemical investigation of amla juice powder and evaluated the antioxidant and neuroprotective effects of the isolates. Ten phenolics (1–10), including gallic acid (1), five gallic acid derivat
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43

Raya-Morquecho, Erick M., Pedro Aguilar-Zarate, Leonardo Sepúlveda, et al. "Ellagitannins and Their Derivatives: A Review on the Metabolization, Absorption, and Some Benefits Related to Intestinal Health." Microbiology Research 16, no. 6 (2025): 113. https://doi.org/10.3390/microbiolres16060113.

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Ellagitannins are bioactive phenolic acids found in various fruits, plants, and beverages such as wine and spirits. This review aims to discuss the metabolism, absorption, and some health benefits related to the intestinal activity of these molecules, as well as some supplements developed from them. Ellagitannins are first biodegraded to ellagic acid and then to urolithins, which are more easily absorbed. This process is mediated by specific enzymes and intestinal microbiota. Not all individuals can metabolize ellagitannins into urolithins due to differences in the composition of the intestina
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44

Liu, Shunzhi, Tao Zhu, Yingkun Qiu, et al. "Chromones and tannins from the fruit of Euscaphis japonica var. wupingensis." BioResources 14, no. 3 (2019): 5355–64. http://dx.doi.org/10.15376/biores.14.3.5355-5364.

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Euscaphis japonica var. wupingensis is a variety of E. japonica in the family Staphyleaceae. The biological characteristics of E. japonica var. wupingensis have been well described, but few studies have been conducted on its constituents. After repeated separation using column chromatography and preparative high performance liquid chromatography (HPLC), ten compounds were isolated from the methanol extract of fruit of E. japonica var. wupingensis. The structure of the components was characterized on the basis of spectroscopic data, including nuclear magnetic resonance (NMR), and mass spectra (
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45

Billard, J., H. Zimmermann, R. Poupko, and Z. Luz. "Ellagic acid derivatives : a new mesogenic series exhibiting a thermotropic cubic mesophase." Journal de Physique 50, no. 5 (1989): 539–47. http://dx.doi.org/10.1051/jphys:01989005005053900.

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Léger, Claude L., Enrique Torres-Rasgado, Gilles Fouret, Céline Lauret, and Marie-Annette Carbonneau. "Ellagic acid and its methyl-derivatives inhibit a newly found nitratase activity." Fundamental & Clinical Pharmacology 24, no. 1 (2010): 115–19. http://dx.doi.org/10.1111/j.1472-8206.2009.00734.x.

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Tabopda, Turibio Kuiate, Joseph Ngoupayo, Jiawei Liu та ін. "α-Glucosidase Inhibitors Ellagic Acid Derivatives with Immunoinhibitory Properties from Terminalia superba". CHEMICAL & PHARMACEUTICAL BULLETIN 56, № 6 (2008): 847–50. http://dx.doi.org/10.1248/cpb.56.847.

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48

Pakulski, Grzegorz, and Jaromir Budzianowski. "Ellagic acid derivatives and naphthoquinones of Dionaea muscipula from in vitro cultures." Phytochemistry 41, no. 3 (1996): 775–78. http://dx.doi.org/10.1016/0031-9422(96)89675-0.

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Chakravarty, Ajit Kumar, Binayak Das, Tapas Sarkar, Kazuo Masuda, and Kenji Shiojima. "ChemInform Abstract: Ellagic Acid Derivatives from the Leaves of Eugenia jambos Linn." ChemInform 30, no. 25 (2010): no. http://dx.doi.org/10.1002/chin.199925211.

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Tenório, Camylla Janiele Lucas, Thainá dos Santos Dantas, Lucas Silva Abreu, Magda Rhayanny Assunção Ferreira, and Luiz Alberto Lira Soares. "Influence of Major Polyphenols on the Anti-Candida Activity of Eugenia uniflora Leaves: Isolation, LC-ESI-HRMS/MS Characterization and In Vitro Evaluation." Molecules 29, no. 12 (2024): 2761. http://dx.doi.org/10.3390/molecules29122761.

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The content of chemical constituents in Eugenia uniflora leaf extracts correlates positively with biological activities. The experimental objective was to carry out the phytochemical screening and purification of the major polyphenols from the leaves of E. uniflora. In addition, the anti-Candida activity of the hydroalcoholic extract, fraction, subfractions and polyphenols purified were evaluated. After partitioning of the extract with ethyl acetate, the fractions were chromatographed on Sephadex® LH-20 gel followed by RP-flash chromatography and monitored by TLC and RP-HPLC. The samples were
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