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Journal articles on the topic 'Epigenomics and epigenetics'

Author: Grafiati

Published: 10 December 2022

Last updated: 31 July 2025

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1

Song, Pengtao, and Biaoru Li. "New Generation of Clinical Epigenetics Analysis and Diagnosis for Precision Medicine." Diagnostics 15, no. 12 (2025): 1539. https://doi.org/10.3390/diagnostics15121539.

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Following the application of epigenetic and epigenomics research into tumor diseases, cardiovascular disease, diabetes, hereditary diseases, and rare diseases, in vitro diagnostics (IVD) epigenetic and epigenomics are increasingly employed for those patients. Here, we review a clinical sampling of epigenetics and epigenomics from patients. We then present procedures, including the detection procedure of clinical epigenetic approaches from clinical samples, clinical epigenomic methods applied to those samples, the small cell number of epigenetics, and epigenomics. Finally, we present the curren

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Bunnik, Eline M., Marjolein Timmers, and Ineke LLE Bolt. "Ethical Issues in Research and Development of Epigenome-wide Technologies." Epigenetics Insights 13 (January 2020): 251686572091325. http://dx.doi.org/10.1177/2516865720913253.

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To date, few scholarly discussions on ethical implications of epigenetics and epigenomics technologies have focused on the current phase of research and development, in which researchers are confronted with real and practical ethical dilemmas. In this article, a responsible research and innovation approach, using interviews and an expert meeting, is applied to a case of epigenomic test development for cervical cancer screening. This article provides an overview of ethical issues presently facing epigenomics researchers and test developers, and discusses 3 sets of issues in depth: (1) informed

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Leite, Michel Lopes, and Fabricio F. Costa. "Epigenomics, epigenetics, and cancer*." Revista Pan-Amazônica de Saúde 8, no. 4 (2017): 23–25. http://dx.doi.org/10.5123/s2176-62232017000400006.

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Jirtle, Randy L. "The science of hope: an interview with Randy Jirtle." Epigenomics 14, no. 6 (2022): 299–302. http://dx.doi.org/10.2217/epi-2022-0048.

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In this interview, Professor Randy L Jirtle speaks with Storm Johnson, Commissioning Editor for Epigenomics, on his work on genomic imprinting, environmental epigenomics and the fetal origins of disease susceptibility. Professor Randy Jirtle joined the Duke University Department of Radiology in 1977 and headed the Epigenetics and Imprinting Laboratory until 2012. He is now Professor of Epigenetics in the Department of Biological Sciences at North Carolina State University, Raleigh, NC, USA. Jirtle's research interests are in epigenetics, genomic imprinting and the fetal origins of disease susc

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Majumder, Sanjoy, Rutupurna Das, Annapurna Sahoo, Kunja Bihari Satapathy, and Gagan Kumar Panigrahi. "Epigenetics, Epigenomics, and Personalized Medicine." Gene Expression 000, no. 000 (2024): 000. http://dx.doi.org/10.14218/ge.2024.00058.

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Peedicayil, J. "Beyond Genomics: Epigenetics and Epigenomics." Clinical Pharmacology & Therapeutics 84, no. 1 (2008): 25–26. http://dx.doi.org/10.1038/clpt.2008.26.

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Kim, Kyoung-Tae, Young-Seok Lee, and Inbo Han. "The Role of Epigenomics in Osteoporosis and Osteoporotic Vertebral Fracture." International Journal of Molecular Sciences 21, no. 24 (2020): 9455. http://dx.doi.org/10.3390/ijms21249455.

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Osteoporosis is a complex multifactorial condition of the musculoskeletal system. Osteoporosis and osteoporotic vertebral fracture (OVF) are associated with high medical costs and can lead to poor quality of life. Genetic factors are important in determining bone mass and structure, as well as any predisposition for bone degradation and OVF. However, genetic factors are not enough to explain osteoporosis development and OVF occurrence. Epigenetics describes a mechanism for controlling gene expression and cellular processes without altering DNA sequences. The main mechanisms in epigenetics are

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Mladenov, Velimir, Vasileios Fotopoulos, Eirini Kaiserli, et al. "Deciphering the Epigenetic Alphabet Involved in Transgenerational Stress Memory in Crops." International Journal of Molecular Sciences 22, no. 13 (2021): 7118. http://dx.doi.org/10.3390/ijms22137118.

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Although epigenetic modifications have been intensely investigated over the last decade due to their role in crop adaptation to rapid climate change, it is unclear which epigenetic changes are heritable and therefore transmitted to their progeny. The identification of epigenetic marks that are transmitted to the next generations is of primary importance for their use in breeding and for the development of new cultivars with a broad-spectrum of tolerance/resistance to abiotic and biotic stresses. In this review, we discuss general aspects of plant responses to environmental stresses and provide

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Dar, Fayaz Ahmad, Naveed Ul Mushtaq, Seerat Saleem, Reiaz Ul Rehman, Tanvir Ul Hassan Dar, and Khalid Rehman Hakeem. "Role of Epigenetics in Modulating Phenotypic Plasticity against Abiotic Stresses in Plants." International Journal of Genomics 2022 (June 14, 2022): 1–13. http://dx.doi.org/10.1155/2022/1092894.

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Plants being sessile are always exposed to various environmental stresses, and to overcome these stresses, modifications at the epigenetic level can prove vital for their long-term survival. Epigenomics refers to the large-scale study of epigenetic marks on the genome, which include covalent modifications of histone tails (acetylation, methylation, phosphorylation, ubiquitination, and the small RNA machinery). Studies based on epigenetics have evolved over the years especially in understanding the mechanisms at transcriptional and posttranscriptional levels in plants against various environmen

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Chen, Xiangsong, and Dao-Xiu Zhou. "Rice epigenomics and epigenetics: challenges and opportunities." Current Opinion in Plant Biology 16, no. 2 (2013): 164–69. http://dx.doi.org/10.1016/j.pbi.2013.03.004.

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Xanthopoulos, Charalampos, and Efterpi Kostareli. "Advances in Epigenetics and Epigenomics in Chronic Lymphocytic Leukemia." Current Genetic Medicine Reports 7, no. 4 (2019): 214–26. http://dx.doi.org/10.1007/s40142-019-00178-3.

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Abstract Purpose of Review The development and progression of chronic lymphocytic leukemia (CLL), a highly heterogenous B cell malignancy, are influenced by both genetic and environmental factors. Environmental factors, including pharmacological interventions, can affect the epigenetic landscape of CLL and thereby determine the CLL phenotype, clonal evolution, and clinical outcome. In this review, we critically present the latest advances in the field of CLL epigenomics/epigenetics in order to provide a systematic overview of to-date achievements and highlight the potential of epigenomics appr

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Płonka, Beata. "Nature or Nurture – Will Epigenomics Solve the Dilemma?" Studia Humana 5, no. 2 (2016): 13–36. http://dx.doi.org/10.1515/sh-2016-0007.

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AbstractThe concept of “nature and nurture” is used to distinguish between genetic and environmental influences on the formation of individual, mainly behavioral, traits. Different approaches that interpret nature and nurture as completely opposite or complementary aspects of human development have been discussed for decades. The paper addresses the most important points of nature vs nurture debate from the perspective of biological research, especially in the light of the recent findings in the field of epigenetics. The most important biological concepts, such as the trait, phenotype and geno

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Hussey, Bethan, Martin R. Lindley, and Sarabjit Mastana. "Epigenetics and epigenomics: the future of nutritional interventions?" Future Science OA 3, no. 4 (2017): FSO237. http://dx.doi.org/10.4155/fsoa-2017-0088.

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Rosen, Evan D., Klaus H. Kaestner, Rama Natarajan, et al. "Epigenetics and Epigenomics: Implications for Diabetes and Obesity." Diabetes 67, no. 10 (2018): 1923–31. http://dx.doi.org/10.2337/db18-0537.

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Qureshi, Irfan A., and Mark F. Mehler. "Advances in Epigenetics and Epigenomics for Neurodegenerative Diseases." Current Neurology and Neuroscience Reports 11, no. 5 (2011): 464–73. http://dx.doi.org/10.1007/s11910-011-0210-2.

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Mathers, John C. "Session 2: Personalised nutrition Epigenomics: a basis for understanding individual differences?" Proceedings of the Nutrition Society 67, no. 4 (2008): 390–94. http://dx.doi.org/10.1017/s0029665108008744.

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Epigenetics encompasses changes to marks on the genome that are copied from one cell generation to the next, which may alter gene expression but which do not involve changes in the primary DNA sequence. These marks include DNA methylation (methylation of cytosines within CpG dinucleotides) and post-translational modifications (acetylation, methylation, phosphorylation and ubiquitination) of the histone tails protruding from nucleosome cores. The sum of genome-wide epigenetic patterns is known as the epigenome. It is hypothesised that altered epigenetic marking is a means through which evidence

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Laird, Peter W. "How epigenomics broke the mold: an interview with Peter W Laird." Epigenomics 14, no. 6 (2022): 303–8. http://dx.doi.org/10.2217/epi-2022-0066.

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In this interview, Professor Peter W Laird speaks with Storm Johnson, Commissioning Editor for Epigenomics, on his work to date in the field of cancer epigenetics. Dr Peter W Laird is a Professor at Van Andel Institute (VAI) in Grand Rapids, Michigan. He earned his B.S. and M.S., Cum Laude, from the University of Leiden, The Netherlands. He trained for his PhD with Dr Piet Borst, The Netherlands Cancer Institute, and as a postdoc with Dr Anton Berns, The Netherlands Cancer Institute, and with Dr Rudolf Jaenisch, at the Whitehead Institute for Biomedical Research in Cambridge, MA, USA. He joine

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Baccarelli, Andrea A., and José Ordovás. "Epigenetics of Early Cardiometabolic Disease: Mechanisms and Precision Medicine." Circulation Research 132, no. 12 (2023): 1648–62. http://dx.doi.org/10.1161/circresaha.123.322135.

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Epigenetics has transformed our understanding of the molecular basis of complex diseases, including cardiovascular and metabolic disorders. This review offers a comprehensive overview of the current state of knowledge on epigenetic processes implicated in cardiovascular and metabolic diseases, highlighting the potential of DNA methylation as a precision medicine biomarker and examining the impact of social determinants of health, gut bacterial epigenomics, noncoding RNA, and epitranscriptomics on disease development and progression. We discuss challenges and barriers to advancing cardiometabol

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Szyf, Moshe. "The epigenetics of early life adversity and trauma inheritance: an interview with Moshe Szyf." Epigenomics 14, no. 6 (2022): 309–14. http://dx.doi.org/10.2217/epi-2021-0483.

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In this interview, Professor Moshe Szyf speaks with Storm Johnson, Commissioning Editor for Epigenomics, on his work to date in the field of social epigenetics. Szyf received his PhD from the Hebrew University and did his postdoctoral fellowship in genetics at Harvard Medical School, joined the Department of Pharmacology and Therapeutics at McGill University in Montreal in 1989 and is a fellow of the Royal Society of Canada and the Academy of Health Sciences of Canada. He is the founding codirector of the Sackler Institute for Epigenetics and Psychobiology at McGill and is a Fellow of the Cana

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Kumar, Parvinder, Amrit Sudershan, Shikha Bharti, Javaid Hassan Sheikh, Showkat Ahmad Wani, and Hardeep Kumar. "Epigenetics in migraine: A review." IP Indian Journal of Neurosciences 9, no. 3 (2023): 122–31. http://dx.doi.org/10.18231/j.ijn.2023.026.

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Genetic diseases are not only caused by direct mutations in "genes," but also consequences of heritable change other than mutation referred to as epigenetics and the science called epigenomics. In the present study, we aimed to review epigenetics, where we covered a quick overview of epigenetics, diseases that are caused by epigenetic modification, epigenetic as risk factors linked with migraine a cause leads to the neurodegenerative condition, and most accepted mechanisms of epigenetics. A structured research article and review of the literature was searched in the electronic databases of Goo

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Baccarelli, Andrea. "ENVIRONMENTAL EPIGENETICS AND AGING." Innovation in Aging 3, Supplement_1 (2019): S735. http://dx.doi.org/10.1093/geroni/igz038.2696.

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Abstract The human epigenome is a flexible, environmental sensitive component of human biology that changes over time. Multiple studies have identified prospective changes in epigenetic marks that indicate that the epigenome ages as we grow older. These changes have been leveraged to create multiple indicators of age that may also predict mortality and age-related disease. There is ongoing research to determine the extent to which age-related epigenomics changes are inherent to cell biology and/or driven by lifestyle and environmental factors. In this presentation, I will review the current ev

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Hoque, Majedul, Kazi Emon, Kazi Emon Md Aktaruzzaman, Md Nahid Hasan, Arafath Jubayer, and Mohammad Sabbir Hossain. "A Mini Review on Cancer Epigenetics." Middle East Research Journal of Medical Sciences 3, no. 02 (2023): 28–38. http://dx.doi.org/10.36348/merjms.2023.v03i02.002.

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Cancer epigenetics is the study of epigenetic changes to cancer cells' DNA that don't involve a change in the nucleotide sequence but instead affect how the genetic code is expressed. The complicated disease of cancer is brought on by genetic and epigenetic changes in the regulation of cell division. Our knowledge of the molecular etiology of cancer has substantially advanced and also the discoveries in the fields of cancer genomics and epigenomics, which have improved our comprehension of the development and evolution of tumorigenic processes. The interaction between genetic and epigenetic mu

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Roy, Suchismita, and Praveen Soni. "Unraveling the Epigenetic Landscape for Salt Tolerance in Plants." International Journal of Plant Biology 13, no. 4 (2022): 443–62. http://dx.doi.org/10.3390/ijpb13040036.

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In every organism, the expression of genes is regulated in response to the changes in the surrounding environment. The study of epigenetics in plants is essential in view of the improvement of agricultural productivity. Epigenetic modifications can enhance crops’ yield and stress tolerance without making any alteration within their genomic sequences. The routes of epigenetic modifications include processes such as methylation of DNA, modifications of histone proteins, chromatin remodeling, and non-coding RNA-mediated regulation of genes. Genome-wide epigenetic profiles, coined as the epigenome

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Alexander, Sheila A. "The Contributions of Nursing to Genetics, Epigenetics, Genomics, and Epigenomics." Biological Research For Nursing 17, no. 4 (2015): 362–63. http://dx.doi.org/10.1177/1099800415586250.

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Kato, Mitsuo, and Rama Natarajan. "Epigenetics and epigenomics in diabetic kidney disease and metabolic memory." Nature Reviews Nephrology 15, no. 6 (2019): 327–45. http://dx.doi.org/10.1038/s41581-019-0135-6.

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Li, Shanyi, Hsiao-Chen Dina Kuo, Ran Yin, et al. "Epigenetics/epigenomics of triterpenoids in cancer prevention and in health." Biochemical Pharmacology 175 (May 2020): 113890. http://dx.doi.org/10.1016/j.bcp.2020.113890.

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Augusto, Ronaldo de Carvalho, Aki Minoda, and Christoph Grunau. "A simple ATAC-seq protocol for population epigenetics." Wellcome Open Research 5 (June 9, 2020): 121. http://dx.doi.org/10.12688/wellcomeopenres.15552.1.

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We describe here a protocol for the generation of sequence-ready libraries for population epigenomics studies. The protocol is a streamlined version of the Assay for transposase accessible chromatin with high-throughput sequencing (ATAC-seq) that provides a positive display of accessible, presumably euchromatic regions. The protocol is straightforward and can be used with small individuals such as daphnia and schistosome worms, and probably many other biological samples of comparable size, and it requires little molecular biology handling expertise.

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Ehrlich, Melanie. "Risks and rewards of big-data in epigenomics research: an interview with Melanie Ehrlich." Epigenomics 14, no. 6 (2022): 351–58. http://dx.doi.org/10.2217/epi-2022-0056.

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Melanie Ehrlich, PhD, is a professor in the Tulane Cancer Center, the Tulane Center for Medical Bioinformatics and Genomics and the Hayward Human Genetics Program at Tulane Medical School, New Orleans, LA. She obtained her PhD in molecular biology in 1971 from the State University of New York at Stony Brook and completed postdoctoral research at Albert Einstein College of Medicine in 1972. She has been working on various aspects of epigenetics, starting with DNA methylation, since 1973. Her group made many first findings about DNA methylation (see below). For example, in 1982 and 1983, in coll

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Pinel, Clémence. "When more data means better results: Abundance and scarcity in research collaborations in epigenetics." Social Science Information 59, no. 1 (2020): 35–58. http://dx.doi.org/10.1177/0539018419895456.

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Drawing upon ethnographic findings from an epigenetics research laboratory in the United Kingdom, this article explores practices of research collaborations in the field of epigenetics, and epigenomics research consortia in particular. I demonstrate that research consortia are key scientific infrastructures that enable the aggregation of masses of data deemed necessary for the production of results and the fostering of epistemic value. Building on Science and Technology Studies (STS) scholarship on value production, and the concept of asset, I show that the production of valuable research with

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Biémont, C. "From genotype to phenotype. What do epigenetics and epigenomics tell us?" Heredity 105, no. 1 (2010): 1–3. http://dx.doi.org/10.1038/hdy.2010.66.

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Agarwal, Gaurav, Himabindu Kudapa, Abirami Ramalingam, et al. "Epigenetics and epigenomics: underlying mechanisms, relevance, and implications in crop improvement." Functional & Integrative Genomics 20, no. 6 (2020): 739–61. http://dx.doi.org/10.1007/s10142-020-00756-7.

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Augusto, Ronaldo de Carvalho, Oliver Rey, Céline Cosseau, et al. "A simple ATAC-seq protocol for population epigenetics." Wellcome Open Research 5 (January 7, 2021): 121. http://dx.doi.org/10.12688/wellcomeopenres.15552.2.

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We describe here a protocol for the generation of sequence-ready libraries for population epigenomics studies, and the analysis of alignment results. We show that the protocol can be used to monitor chromatin structure changes in populations when exposed to environmental cues. The protocol is a streamlined version of the Assay for transposase accessible chromatin with high-throughput sequencing (ATAC-seq) that provides a positive display of accessible, presumably euchromatic regions. The protocol is straightforward and can be used with small individuals such as daphnia and schistosome worms, a

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Ramos, Paula S. "Epigenetics of scleroderma: Integrating genetic, ethnic, age, and environmental effects." Journal of Scleroderma and Related Disorders 4, no. 3 (2019): 238–50. http://dx.doi.org/10.1177/2397198319855872.

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Scleroderma or systemic sclerosis is thought to result from the interplay between environmental or non-genetic factors in a genetically susceptible individual. Epigenetic modifications are influenced by genetic variation and environmental exposures, and change with chronological age and between populations. Despite progress in identifying genetic, epigenetic, and environmental risk factors, the underlying mechanism of systemic sclerosis remains unclear. Since epigenetics provides the regulatory mechanism linking genetic and non-genetic factors to gene expression, understanding the role of epig

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Pfeifer, Gerd P. "The ups and downs of DNA methylation: an interview with Gerd Pfeifer." Epigenomics 14, no. 6 (2022): 339–43. http://dx.doi.org/10.2217/epi-2021-0485.

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In this interview, Professor Gerd Pfeifer speaks with Storm Johnson, Commissioning Editor for Epigenomics, on his work to date in the field of DNA methylation. Dr Pfeifer received a PhD degree from the University of Frankfurt, Germany. After postdoctoral work, he became a faculty member at the Beckman Research Institute of the City of Hope (Duarte, CA) in 1991. He is currently a full professor at the Van Andel Institute in Grand Rapids, MI. Dr. Pfeifer has served on several NIH advisory committees and has published over 300 research papers. Dr Pfeifer's research interests are cancer etiology,

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Silva, Tiago C., Antonio Colaprico, Catharina Olsen, et al. "TCGA Workflow: Analyze cancer genomics and epigenomics data using Bioconductor packages." F1000Research 5 (June 29, 2016): 1542. http://dx.doi.org/10.12688/f1000research.8923.1.

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Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA), The Encyclopedia of DNA Elements (ENCODE), and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap). These projects have provided unprecedented opportunities to interrogate the epigenome of cultured cancer cell lines as well as normal and tumor tissues with high genomic resolution. The bioconductor project offers more than 1,000 open-source software and statistical packages to analyze high-throughput genomic data. However, mos

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Silva, Tiago C., Antonio Colaprico, Catharina Olsen, et al. "TCGA Workflow: Analyze cancer genomics and epigenomics data using Bioconductor packages." F1000Research 5 (December 28, 2016): 1542. http://dx.doi.org/10.12688/f1000research.8923.2.

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Biotechnological advances in sequencing have led to an explosion of publicly available data via large international consortia such as The Cancer Genome Atlas (TCGA), The Encyclopedia of DNA Elements (ENCODE), and The NIH Roadmap Epigenomics Mapping Consortium (Roadmap). These projects have provided unprecedented opportunities to interrogate the epigenome of cultured cancer cell lines as well as normal and tumor tissues with high genomic resolution. The Bioconductor project offers more than 1,000 open-source software and statistical packages to analyze high-throughput genomic data. However, mos

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Šrut, Maja. "Environmental Epigenetics in Soil Ecosystems: Earthworms as Model Organisms." Toxics 10, no. 7 (2022): 406. http://dx.doi.org/10.3390/toxics10070406.

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One of the major emerging concerns within ecotoxicology is the effect of environmental pollutants on epigenetic changes, including DNA methylation, histone modifications, and non-coding RNAs. Epigenetic mechanisms regulate gene expression, meaning that the alterations of epigenetic marks can induce long-term physiological effects that can even be inherited across generations. Many invertebrate species have been used as models in environmental epigenetics, with a special focus on DNA methylation changes caused by environmental perturbations (e.g., pollution). Among soil organisms, earthworms ar

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Lee, Daniel Y. "Cancer Epigenomics and Beyond: Advancing the Precision Oncology Paradigm." Journal of Immunotherapy and Precision Oncology 3, no. 4 (2020): 147–56. http://dx.doi.org/10.36401/jipo-20-18.

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ABSTRACT How cancers are characterized and treated has evolved over the past few decades. Major advances in genomics tools and techniques have revealed interlinked regulatory pathways of cancers with unprecedented detail. Early discoveries led to success with rationally targeted small molecules and more recently with immunomodulatory agents, setting the stage for precision oncology. However, drug resistance to every agent has thus far proven intractable, sending us back to fill the gaps in our rudimentary knowledge of tumor biology. Epigenetics is emerging as a fundamental process in every hal

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Kelsey, Karl. "Epigenetics, environment and epidemiology: an interview with Karl Kelsey." Epigenomics 14, no. 6 (2022): 323–26. http://dx.doi.org/10.2217/epi-2022-0008.

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In this interview, Professor Karl Kelsey speaks with Storm Johnson, Commissioning Editor for Epigenomics, on his work to date in the field of environmental epigenomics and epidemiology. Dr Karl Kelsey, MD, MOH is a Professor of Epidemiology and Pathology and Laboratory Medicine at Brown University. He is the Founding Director of the Center for Environmental Health and Technology and Head of the Environmental Health Section at the Department of Epidemiology. Dr Kelsey is interested in the application of laboratory-based biomarkers in environmental disease, with experience in chronic disease epi

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Goodrich, Jaclyn. "Insights on exposure-induced disease susceptibility: an interview with Jaclyn Goodrich." Epigenomics 14, no. 6 (2022): 319–21. http://dx.doi.org/10.2217/epi-2022-0046.

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In this interview, Dr Jaclyn Goodrich speaks with Storm Johnson, Commissioning Editor for Epigenomics, on her work to date on environmental epigenetics and the impact of toxic exposures on susceptible populations. Jaclyn Goodrich is a research assistant professor of environmental health sciences at the University of Michigan School of Public Health (Ann Arbor, MI, USA). She obtained a doctorate in toxicology and completed postdoctoral training in environmental epigenomics at the University of Michigan. The overarching goal of her current research program is to identify environmental factors th

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Abdelmoula, E., B. Abdelmoula, and N. Bouayed Abdelmoula. "Embodied cognition and urban design: Thoughts through epigenetic advances." European Psychiatry 67, S1 (2024): S626—S627. http://dx.doi.org/10.1192/j.eurpsy.2024.1299.

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IntroductionIn the history of urban planning, the cognitive trend has been a well-established entity since the work of the American urban planner during the mid-’90s; Kevin Lynch. However, for a long time, urban planning has been deprived of the contribution of scientific knowledge from cognitive neurosciences, with a lack of operational recommendations for urban projects.ObjectivesThis study aims to reveal the role of embodiment theories in the revolution of urban design and urban projects through emerging findings in epigenetics and post-genomic biology.MethodsWe conducted an exhaustive revi

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Figueroa, Maria Eugenia, John Greally, Ruud Delwel, and Ari M. Melnick. "Genome-Wide Epigenetics in Myeloid Leukemias." Blood 112, no. 11 (2008): sci—35—sci—35. http://dx.doi.org/10.1182/blood.v112.11.sci-35.sci-35.

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Abstract While the role of genetic alterations in cancer is well-recognized, epigenetic deregulation has only recently been identified as a hallmark of malignant transformation. The term “epigenetic” refers to a heritable regulation of gene expression that is not dependent on changes in the DNA sequence. These epigenetic modifications – including but not limited to DNA methylation and covalent modifications of histone tails – play a crucial role in determining chromatin structure and gene expression. Abnormal epigenetic regulation can lead to aberrant chromatin structure and deregulation of tr

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Lakshmi Priya R and Devi S. Nair. "Ayurvedic Personalized Healthcare: Integrating Genomics, Epigenomics and Traditional Wisdom." Journal of Ayurveda and Integrated Medical Sciences 9, no. 11 (2025): 192–97. https://doi.org/10.21760/jaims.9.11.27.

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In the evolving landscape of personalized medicine, integrating Ayurvedic principles with modern genomic science presents a transformative opportunity for healthcare. This paper explores the concept of Prakriti, the unique constitution of individuals as defined in Ayurveda, and its potential correlation with genetic profiles. By merging Ayurvedic insights with genomic and epigenomic research, we propose a framework for personalized healthcare that considers both genetic predispositions and lifestyle factors. The study outlines practical approaches, including the use of Single Nucleotide Polymo

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Dudley, K. J., K. Revill, R. N. Clayton, and W. E. Farrell. "Pituitary tumours: all silent on the epigenetics front." Journal of Molecular Endocrinology 42, no. 6 (2009): 461–68. http://dx.doi.org/10.1677/jme-09-0009.

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Investigation of the epigenome of sporadic pituitary tumours is providing a more detailed understanding of aberrations that characterise this tumour type. Early studies, in this and other tumour types adopted candidate-gene approaches to characterise CpG island methylation as a mechanism responsible for or associated with gene silencing. However, more recently, investigators have adopted approaches that do not require a priori knowledge of the gene and transcript, as example differential display techniques, and also genome-wide, array-based approaches, to ‘uncover’ or ‘unmask’ silenced genes.

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Wu, Renyi, Lujing Wang, Ran Yin, et al. "Epigenetics/epigenomics and prevention by curcumin of early stages of inflammatory‐driven colon cancer." Molecular Carcinogenesis 59, no. 2 (2019): 227–36. http://dx.doi.org/10.1002/mc.23146.

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Karlsson, Oskar. "Epigenetics in the Anthropocene: an interview with Oskar Karlsson." Epigenomics 14, no. 6 (2022): 315–18. http://dx.doi.org/10.2217/epi-2022-0044.

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In this interview, Oskar Karlsson speaks with Storm Johnson, commissioning editor for Epigenomics, on his work to date in the field of toxicological origins of disease and gene–environment interactions. Oskar Karlsson, is an associate professor at the Science for Life Laboratory (SciLifeLab), Department of Environmental Science, Stockholm University, Sweden. Dr. Karlsson earned a PhD in toxicology at the Department of Pharmaceutical Bioscience, Uppsala University, and has also worked at Centre of Molecular Medicine, Karolinska Institute, as well as Harvard University School of Public Health. H

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Shema, Efrat. "Abstract PR006: Single-molecule and single-cell epigenetics: Decoding the epigenome for cancer research and diagnostics." Cancer Research 82, no. 23_Supplement_2 (2022): PR006. http://dx.doi.org/10.1158/1538-7445.cancepi22-pr006.

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Abstract Genes and genomic elements are packaged by chromatin structures that regulate their activity. We developed a novel high-throughput single-molecule imaging technology to decode combinatorial modifications on millions of individual nucleosomes. We apply this technology to image nucleosomes and delineate their combinatorial epigenetic patterns, and how these patterns are deregulated in cancer. In addition, we adapt single-cell technologies based on CyTOF to profile the global levels of multiple histone modifications in single cells, thus revealing epigenetic heterogeneity in cancer. Our

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Oliveira, Carolliny Texeira Neves, José Pedro Lima Marinho de Andrade, Lídian Sarah Rocha Vieira Sampaio, Marco Túlio Silva Jardim, and Kleber Alves Gomes. "TRANSTORNO DO ESPECTRO AUTISTA E SUA RELAÇÃO COM A EPIGENÉTICA: UMA REVISÃO DOS IMPACTOS NO DESENVOLVIMENTO INFANTIL." Revista ft 29, no. 143 (2025): 15–16. https://doi.org/10.69849/revistaft/ar10202502102015.

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Objective: To analyze how epigenetic mechanisms influence the development of Autism Spectrum Disorder (ASD) in childhood and analyze the implications of these influences for diagnosis and therapeutic approaches. Methods: An integrative literature review conducted in December 2024, using databases such as PubMed, SCIELO, and Acervo+ Index Base. The search utilized descriptors such as "Autism Spectrum Disorder”, “Autistic Disorder”, “Epigenomics”, “Multifactorial Inheritance” e “Developmental Disabilities", combined with the Boolean operator “AND”. Articles published between 2014 and 2024, with

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Al Jowf, Ghazi I., Clara Snijders, Bart P. F. Rutten, Laurence de Nijs, and Lars M. T. Eijssen. "The Molecular Biology of Susceptibility to Post-Traumatic Stress Disorder: Highlights of Epigenetics and Epigenomics." International Journal of Molecular Sciences 22, no. 19 (2021): 10743. http://dx.doi.org/10.3390/ijms221910743.

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Exposure to trauma is one of the most important and prevalent risk factors for mental and physical ill-health. Excessive or prolonged stress exposure increases the risk of a wide variety of mental and physical symptoms. However, people differ strikingly in their susceptibility to develop signs and symptoms of mental illness after traumatic stress. Post-traumatic stress disorder (PTSD) is a debilitating disorder affecting approximately 8% of the world’s population during their lifetime, and typically develops after exposure to a traumatic event. Despite that exposure to potentially traumatizing

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Zotenko, Elena, Rachel Gittelman, Alan Selewa, et al. "Abstract 1955: Blood-based mapping of the personalized tumor epigenomic landscape." Cancer Research 85, no. 8_Supplement_1 (2025): 1955. https://doi.org/10.1158/1538-7445.am2025-1955.

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Abstract Background: Mapping the epigenetic landscape of tumors provides insights into regulatory and functional aspects beyond somatic mutations, offering valuable information that can influence clinical decisions and benefit the patient journey. Given the challenges of obtaining tissue biopsies, especially in the longitudinal monitoring or progression setting as tumors evolve due to selective pressure from treatment, the advantages of non-invasive liquid biopsies to characterize tumors through blood are highly beneficial. Here, we demonstrate that the epigenetic landscape of a patient’s tumo

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