To see the other types of publications on this topic, follow the link: Evaluation of cream preparation.
Journal articles on the topic 'Evaluation of cream preparation'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 journal articles for your research on the topic 'Evaluation of cream preparation.'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse journal articles on a wide variety of disciplines and organise your bibliography correctly.
1
Kiran, Gokul khandekar Rahul Jagtap. "Review On Preparation And Evaluation Of Moisturizing Cream." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 363–68. https://doi.org/10.5281/zenodo.11506311.
Full textAbstract:
Moisturizing cream are semi solids preparation used for reduces the chances of skin problems and fights wrinkles. The main aim of the research work is to prepare the moisturizing creams using different herbs and the prepared moisturizing cream are evaluated for the efficacy. The herbs used in the preparations are dried Ficus racemose leaves powder and cucumber peels the formulated moisturizing creams are evaluated for the various irritancy, washability, ph, viscosity, phase separation, spread ability, compatibility test. The results shown that all formulation gave satisfied results.
2
Maha, Hetty Lendora, Kasmirul Ramlan Sinaga, Kasmirul Ramlan Sinaga, Masfria Masfria, and Masfria Masfria. "FORMULATION AND EVALUATION OF MICONAZOLE NITRATE NANOEMULSION AND CREAM." Asian Journal of Pharmaceutical and Clinical Research 11, no. 3 (2018): 319. http://dx.doi.org/10.22159/ajpcr.2018.v11i3.22056.
Full textAbstract:
Objective: The present study is to determine the evaluation profile of the preparations nanoemulsion and cream of miconazole nitrate.Methods: Preparation of nanoemulsi with concentrations 1%, 1.5%, and 2% using the principle of low-energy emulsification and miconazole nitrate cream was then performed physical evaluation of the preparation which included organoleptic test, pH measurement, viscosity test, emulsion type, cycling test, centrifugation test, particle size measurement with particle size analyzer, and homogeneity test of cream preparations.Result: Based on organoleptic test, it can be seen that the miconazole nitrate nanoemulsion preparations produced are clear, colored weak yellow, and the cream is white. The average pH of the nanoemulsion preparations ranged from 6.01 to 6.25, while the cream preparations were 5.95–6.52. The average viscosity values of nanoemulsion preparations were 1707 cps, 1920 cps, and 1987 cps, respectively. In the cycling test, the nanoemulsion preparation remained weak yellow and odorless, and the cream preparation remained white and did not experience phase separation. In the centrifugation test, the nanoemulsion preparation and the cream were centrifuged at a rate of 3800 for 5 h, after centrifugation tests, both the nanoemulsing and cream preparations did not show any phase separation, in the nanoemulsion preparation possibly due to the high viscosity of the preparation. On the type nanoemulsi test, by dripping methylene blue on the formula. After observed, the blue methylene is evenly dispersed into the formula, indicating that all four formulas have an oil-in-water emulsion type (o/w). The particle size of the nanoemulsion preparation ranged from 102.36 nm to 309.11 nm.Conclusion: The results of evaluation of miconazole nitrate nanoemulsion preparations were better than cream preparations.
3
Roshan, Yadav, Kant Thakur Shiva, Parihar Rishabh, Singh Chawra Himmat, Chauhan Uma, and Chanana Arsh. "Pharmaceutical Preparation and Evaluation of Cold Cream." International Journal of Innovative Science and Research Technology 8, no. 5 (2023): 1069–75. https://doi.org/10.5281/zenodo.7972409.
Full textAbstract:
Since the beginning of time, creams have been valued as essential topical preparations in cosmetic products because of how simple it is to apply and remove them from the skin. Pharmaceutical creams are used for a number of aesthetic purposes, including cleansing, beautifying, modifying look, moisturising, etc. They also protect the skin from bacterial and fungal infections and can be used to treat skin injuries including burns, cuts, and wounds. The general population and society can safely employ these semi-solid preparations. The products used to enhance and beautify human appearances are known as herbal cosmetics. The current study's objective was to design and assess herbal cold creams that contained plant extracts made utilising the water in oil method for the goal of moisturising and nourishing the skin.Neem oil and turmeric extract are used to make the cold cream. Utilising several evaluation techniques, the created product’s quality was evaluated. The physical characteristics of the cream formulation did not alter. During the research study period, the cream formulation demonstrated good consistency and spreadability, homogeneity, pH, non-greasy properties, and no signs of phase separation. There was no discernible change in the created cream’s viscosity, aroma, or visual appearance during the research period, according to stability measures. As the water in the emulsion slowly evaporates, the cooling and calming effects of the herbal extract with cold cream are produced. Cold creams are more moisturising because they create an oily barrier to stop the loss of water from the stratum corneum, the outermost layer of the skin. They are water-in-oil emulsion and intended for application on skin or accessible mucous membrane to provide localized and sometimes systemic effect at the site of application
4
Ramdhan, Bahariyan, and Anna L. Yusuf. "Formulation and Evaluation of Avocado Leaf Extract (Persea americana Mill.) Cream Based on Variations Stearic Acid Concentration." Ad-Dawaa : Journal of Pharmacy 1, no. 2 (2023): 78–86. http://dx.doi.org/10.52221/dwj.v1i2.412.
Full textAbstract:
Avocado leaves (Persea americana Mill.) contain flavonoid compounds as high as 8.11 mg, so they have potential in the acne healing process. The aim of this research is to create a formulation and evaluate an avocado leaf extract cream preparation. The method used is experimental. Avocado leaf extract cream preparations are made based on varying stearic acid concentrations of 5%, 10% and 15%. Evaluation of the preparation includes organoleptic tests, homogeneity tests, pH tests, spreadability tests, adhesion tests, and viscosity tests. Based on the organoleptic evaluation, the results showed that FI was slightly runny and contained bubbles, FII was slightly thick and FIII was thick. The FI color is brownish white, FII is yellowish white, and FIII is white, and all formulations have a characteristic creamy odor. The homogeneity test shows that all formulas have the same homogeneous preparation. The pH test of the cream preparation showed the same pH value, namely 6. The spreadability test resulted in good spreadability of the cream, namely between 5 and 6.8 cm. The cream adhesion test has an adhesion between 00.53 and 1.38 seconds. And finally, the viscosity test has a viscosity value between 4500 and 8900 mpa. According to the results of this research, avocado leaf extract cream can be used as a cream preparation, with the best stearic acid concentration being 15%.
5
Lwin, Wai Wai, Napaphol Puyathorn, and Takron Chantadee. "Cold-Pressed Coconut Oil Cream: Preparation and Evaluation." Key Engineering Materials 914 (March 21, 2022): 23–29. http://dx.doi.org/10.4028/p-408j21.
Full textAbstract:
Typically, the emollient effect of the vegetable oil has attributed to its usefulness in skin care preparation. The present study aims to prepare the oil in water emulsion cream containing virgin coconut oil (CO) comprisinghydrophilic and lipophilic surfactants (Tween 80 and Span 80). Stability of creams containing CO upon addition of peppermint oil (PO), co-surfactant (Solutol HS 15, ST), solubilizer (benzyl benzoate, BB) was investigated after the temperature cycling. All prepared creams showed the shear thinning flow behavior. Addition of BB gave the lowest viscosity while that comprising ST exhibited the higher viscosity. The highest viscosity formula was the CO andPO containing cream. The particle size determined using light scattering particle analyzer revealed that the mean particle size of all prepared creamswaslower than 35.56 ± 0.62 µm. The homogenous dispersion of oil globules in emulsion was evident, especially, in formulation II (CO) and IV (COand ST). Although the temperature cycling influenced more or less on the compact structure of gel network of cream, the decrement of viscositywasminimal and not much different for cream containing CO and ST (formulation IV). In addition, the mean particle size wasthe smallest for formulation II (CO) which was followed by formulation IV (CO and ST). There wasthe homogenous dispersion of oil globules in formulation II and IV after temperature cycling. All of the above finding was beneficial for employingCO as the oil phase in producing cream such as the foot massage cream where the addition of ST provided the better stability for the prepared cream containing CO.
6
Yanuarti, Rini, Nurfitriyana Nurfitriyana, Ginanjar Pratama, and Muhammad Zuhriyanto. "Aktivitas Antioksidan dan Evaluasi Fisik Sediaan Body Scrub dari Bubur Rumput Laut Boergesenia forbesii dan Serbuk Kencur (Kaempferia galanga)." Jurnal FishtecH 11, no. 2 (2022): 66–73. http://dx.doi.org/10.36706/fishtech.v11i2.18012.
Full textAbstract:
Seaweed has bioactive components that are very much needed in cosmetic preparations, in addition to seaweed, natural ingredients that can be used are kencur (Kaempferia galanga). This study aims to determine the best combination of B. forbesii seaweed porridge and kencur (K. galanga) powder as a body scrub preparation from the results of antioxidant activity and physical evaluation. This research was conducted by looking at the difference in concentration between B. forbesii and kencur (K. galanga) seaweed with a ratio of 1:1 (R1 cream), 1:2 (R2 cream), and 2:1 (R3 cream) and without the addition of seaweed. and Moringa (R0). The cream preparation was then tested for antioxidants and physical evaluation of the preparation included pH, homogeneity, centrifugal test, and organoleptic observations. The test results showed that all formulations of body scrub cream which were given B. forbesii seaweed porridge and kencur (K. galanga) powder had weak antioxidant activity. The results of the evaluation of physical preparations showed good results for the skin, but the formulation of R2 cream which is the best cream seen from the overall evaluation results
7
Suci Fitriani, Aprilya Sri Rachmayanti, and Reny Haryani. "Formulasi dan Uji Stabilitas Krim Ekstrak Daun Jambu Mete (Ancardium Ocidentale Linn)." Jurnal Ilmu Kedokteran dan Kesehatan Indonesia 1, no. 3 (2021): 206–19. http://dx.doi.org/10.55606/jikki.v1i3.2942.
Full textAbstract:
This research aims to evaluate the formulation and stability of cashew leaf extract cream (Anacardium occidentale Linn) as the active ingredient. The research method includes cashew leaf sampling, plant identification, leaf preparation, extraction, phytochemical screening, cream preparation, cream evaluation, and physical stability testing. Phytochemical screening results indicate the presence of tannins, flavonoids, and saponins in the cashew leaf extract. The cream formulation of cashew leaf extract was prepared using concentrations of 6%, 10%, and 14%. Cream evaluation includes organoleptic aspects, cream type, spreadability, pH, viscosity, and physical stability testing. The research findings show that creams containing cashew leaf extract at different concentrations and stored for 4 weeks at room temperature, low temperature, and 40°C demonstrate relatively stable physical stability. Statistical analysis has been conducted on the evaluation results, and the findings will be discussed in detail. This research concludes that cashew leaf extract cream formulations exhibit good physical stability during the tested storage period. These findings provide a better understanding of the formulation and stability of creams containing cashew leaf extract, which can serve as a basis for the development of more effective and stable pharmaceutical products in the future.
8
Biru, Kumar Thakur, Kumar Atul, Kumar Abhimanyu, Kumar Rana Mukesh, Parween Saba, and Kumar Ajeet. "A Review on Preparation and Evaluation of Cream." Pharmaceutical and Chemical Journal 12, no. 2 (2025): 110–16. https://doi.org/10.5281/zenodo.15606736.
Full textAbstract:
Creams are considered an important part of cosmetic product as topical preparations from time immemorial due to their ease of application to the skin and also their removal. From cosmetic purposes, Pharmaceutical creams have a variety of applications such as cleansing, beautifying, altering appearance, moisturizing etc. to skin protection against bacterial, fungal infections as well as healing cuts, burns, wounds on the skin. The current study's objective was to design and assess herbal cold creams that contained plant extracts made utilising the water in oil method for the goal of moisturising and nourishing the skin. Neem oil and turmeric extract are used to make the cold cream. Utilising several evaluation techniques, the created product's quality was evaluated. The herbal extract containing moisturizing cream gives the cooling and soothing effect due to slow evaporation of water present in the emulsion. The moisturizing creams are more moisturizing as they provide an oily barrier which reduces the water loss from the stratum corneum, the outermost layer of the skin. They are water-in-oil emulsion and intended for application on skin or accessible mucous membrane to provide localized and sometimes systemic effect at the site of application.
9
Estefania, Kaban Vera, Jansen Silalahi, Sumaiyah Sumaiyah, and Denny Satria. "Formulation and Evaluation of Cream Turmeric Extract Preparations from Turmeric Rhizomes (Curcuma domestica Val.)." Indonesian Journal of Pharmaceutical and Clinical Research 5, no. 1 (2022): 01–09. http://dx.doi.org/10.32734/idjpcr.v5i1.6479.
Full textAbstract:
The use of plants as a method of herbal treatment is a step that is currently being developed by many researchers to produce effective and minimal side effects. Turmeric is one of the most widely used cooking spices by the people of Indonesia. The main ingredients possessed by turmeric include curcumin (77%), demethoxy (17%) and bisdemethoxy (3%). One of the pharmaceutical preparations with a topical delivery system is a cream preparation which is a semi-solid dosage form, containing one or more drug ingredients dissolved or dispersed in an appropriate base material. Turmeric can be formulated in various preparations, one of which is a cream dosage form. The advantage of using cream preparations is that they are practical, easy to wash and clean. The purpose of this study was to formulate turmeric extract in a cream preparation. The results of the evaluation test showed that the formula produced a cream with a yellow-orange color, a characteristic odor of turmeric, and a preparation with a semisolid cream texture, had good homogeneity, good dispersing ability, the pH of the preparation was 5.84; 6.32; 6.24; 5,94;5,94 and the type of emulsion is O/W (Oil in Water).
10
Ms., Chetana D. Patil, Rutika U. More Ms., and Pooja S. Bhandare Mrs. "Hydrotropic Cream Preparation from Licorice Extract." International Journal of Trend in Scientific Research and Development 3, no. 5 (2019): 707–10. https://doi.org/10.5281/zenodo.3590995.
Full textAbstract:
The current work aimed to formulate a stable w o cream containing Glycyrrhiza glabra extract and studying its effects on skin pigment. Glycyrrhiza glabra Extract obtained by concentrating the alcoholic extract of Glycyrrhiza glabra roots was entrapped in the inner aqueous phase of W O emulsion. Base containing no active material and a formulation containing ethanolic extract of Glycyrrhiza glabra 1 were prepared. Samples of base and formulation were stored at different accelerated conditions 8°C, 25°C, 40°C, 40°C 75 RH for four weeks to predict the stability of creams. Base and formulation were stable at all accelerated conditions regarding color, liquefaction and phase separation. Both creams were good for sensory evaluation. Ms. Chetana D. Patil | Ms. Rutika U. More | Mrs. Pooja S. Bhandare "Hydrotropic Cream Preparation from Licorice Extract" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-5 , August 2019, URL: https://www.ijtsrd.com/papers/ijtsrd26435.pdf
11
Miftahurrahman, Miftahurrahman, Teuku Khaiyir Raqi Ariz, Dara Rizkya Aura, Nanda Arulia, and Munira Munira. "Pemanfaatan buah andaliman (Zanthoxylum acanthopodium) dari Dataran Tinggi Gayo dalam pembuatan krim antibakteri." Jurnal SAGO Gizi dan Kesehatan 5, no. 2 (2024): 563. http://dx.doi.org/10.30867/gikes.v5i2.1760.
Full textAbstract:
Background: The andaliman fruit, scientifically known as Zanthoxylum acanthopodium is a traditional spice rich in essential oils. The fruit chemicals including alkaloids, flavonoids, steroids, tannins, and saponins, providing antibacterial potential. Chemical composition is influenced by environmental factors such as light exposure, temperature fluctiotions, pH levels, altitude, and humidity. The Gayo Highlands in Aceh Province have a significant influence on the chemical composition of plant due to their altitude and typical tempteratures.Objectives: This research aims to formulate andaliman fruit extract which grows in the Gayo Highlands into an antibacterial cream preparation and test its antibacterial activity.Methods: This research is experimental by making extracts, formulating andaliman fruit extract cream (0%, 2%, 3,5%, 5%, and 6,5%). Carrying out evaluation of cream preparations includes organoleptic examination, homogeneity test, pH examination and antibacterial test. The bacterial inhibitory power was analyzed using the Anova test and followed by the Duncan test.Results: The results of the preparation evaluation show that andaliman fruit extract cream meets all the criteria as a cream preparation where the pH ranges from 5,6 – 6,8. The findings of the antibacterial test proved the significant impact of the andaliman fruit cream from the Gayo highlands in inhibiting the growth of Staphylococcus aureus (P= 0,000).Conclusion: Cream preparations extract of andaliman fruit, it was concluded that all formulations met the evaluation criteria for cream preparations. The substantial diameter of the inhibition zone indicates the potential of the cream as an effective antibacterial.
12
Roy, Jayita, Arna Pal, and Sudipta Chakraborty. "Herbal Creams: An Overview." International Journal of Health Sciences and Research 14, no. 7 (2024): 136–44. http://dx.doi.org/10.52403/ijhsr.20240717.
Full textAbstract:
Semi solid dosage forms that are usually applied topically on skin are called creams. This study mainly focuses on the preparation and evaluation of herbal creams along with some of the common herbs utilized in these types of formulations. The herbal cream is basically water in oil type of emulsion. The natural ingredients chosen for preparation of herbal cream are Turmeric, Papaya, Aloe-Vera, Tulsi, Amla, Cucumber, Neem. The choice of these ingredients is based on their individual properties. The preparation of the cream is basically done by using the cream base i.e., liquid paraffin, beeswax, borax, methyl paraben. These formulations can be evaluated by various parameters like pH, viscosity, irritancy, spreadability, microbial growth, thermal stability, homogeneity, acid value, saponification value, accelerated stability studies, patch test, smear test, after feel, washability, physical properties, dye test, after feel, in vitro diffusion study, etc. Chemical based cosmetics are harmful to the skin and an increased awareness among consumers for herbal products triggered the demand for natural products and natural extracts in cosmetics preparations. The increased demand for the natural product has created new avenues in cosmeceutical market. The natural content in the botanicals does not cause any side effects on the human body; instead enrich the body with nutrients and other useful minerals. Key words: Cosmetics, herbal creams, semisolid dosage forms, turmeric, aloe vera.
13
Aldila, Silvy, Ranatri Puruhita, Syahkhirotul Exma Uliana, Anifatus Sa’adah, and Fransisca Gloria. "BROCCOLI (Brassica oleracea L) ETHANOL EXTRACT: A MOISTURIZER AND ITS EVALUATION IN ASPECTS OF PHYSICAL CHARACTERISTICS." Science and Community Pharmacy Journal 3, no. 1 (2024): 185–95. https://doi.org/10.63520/scpj.v3i1.545.
Full textAbstract:
Skin disorders that are dry, dull, scaly, and not fresh affect everyone. Moisturizing cream is a cosmetic product that effectively hydrates and improves dry skin. Broccoli, scientifically known as Brassica oleracea L, is rich in vitamin C components, vitamin E (α-tocopherol), and flavonoids, which act as natural antioxidants and provide moisturizing properties for the skin. Producing extracts by the maceration process. Broccoli extract is utilized in the formulation of four moisturizing cream preparation compositions, each with a concentration of F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage characteristics of moisturizing creams, includes organoleptic testing, homogeneity testing, pH testing, dispersion testing, adhesion testing, and viscosity testing. The concentration of broccoli extract in the four moisturizing cream preparation formulations is as follows: F1 (0%), F2 (2%), F3 (3%), and F4 (4%). The moisturizing cream formulation is assessed for its physical properties. Conducting tests to evaluate the dosage properties of moisturizing creams, including sensory evaluation, uniformity assessment, pH measurement, dispersion analysis, adhesion examination, and viscosity measurement
14
Tammewar, Samiksha, and Ujban Md Hussain Hussain. "Preparation Evaluation and Comparative Studies of Herbal Face Cream." International Journal of Science and Research (IJSR) 12, no. 10 (2023): 2043–49. http://dx.doi.org/10.21275/sr231025210543.
Full text
15
Syaputri, Fauzia Ningrum, and Vinda Maharani Patricia. "Formulation and Physical Characterization of Onion (Allium ascalonicum L) Bulb Extract in Cream Using Tween 80 and Span 60 as the Emulgator." Jurnal Sains dan Kesehatan 2, no. 2 (2019): 115–20. http://dx.doi.org/10.25026/jsk.v2i2.138.
Full textAbstract:
In Indonesia, it is not uncommon to find children who suffer from fever which can occur due to the change of weather from the rainy season during the dry season or vice versa. Communities in rural areas generally use onion (Allium ascalonicum L) to relieve fever in children. Cream preparations are made by varying the concentration of the emulgator to determine the effect of different concentrations of the emulgator on the physical characteristics of the cream preparation. The emulgator used is tween 80 and span 60 with a concentration of Formula 1: 3.5%, Formula 2: 3.75%, formula 3: 4%. Physical evaluations carried out in this study were organoleptic, pH, homogeneity, cream washability, cream type, viscosity, spreadability, adhesion, and freeze-thaw tests. The results of the study it can be concluded that the differences in the concentration of the emulgator can affect the physical characteristics of the cream preparation, namely in the spreading test and the adhesion test shows that F3 (4%) can reduce the spreadability of the cream preparation but can be attached to a long time when compared to F1 (3.5%) and F2 (3.75%). The physically optimal cream preparation formula is F1 and F2 because it meets all the requirements in the evaluation test.
 
 Keywords: Cream, onion, emulgator, physical characteristics
16
Hasniar, Hasniar, Yusriadi Yusriadi, and Akhmad Khumaidi. "FORMULASI KRIM ANTIOKSIDAN EKSTRAK DAUN KAPAS (Gossypium sp.)." Jurnal Farmasi Galenika (Galenika Journal of Pharmacy) (e-Journal) 1, no. 1 (2015): 9–15. http://dx.doi.org/10.22487/j24428744.2015.v1.i1.4830.
Full textAbstract:
Gossypium sp. leaf is one of the plants that contain flavonoids that can act as antioxidants. This study aims to look at the effect of combination of the stearic acid and triethanolamine which function as emulsifier in creams and determine antioxidant activity of cream Gossypium sp. leaf extract. Cream is formulated with a variety of stearic acid and triethanolamine emulsifier that F1 (8%: 2%), F2 (12%: 3%), F3 (16%: 4%). Tests carried out at the first day and the 28th days. Evaluation preparations include organoleptic test, homogeneity, viscosity, pH, and type of the cream. The results showed that the variation of concentration emulsifier that fill quality preparations with some parameters such as organoleptic, homogeneity, the type of cream and viscosity. pH of cream does not qualify are 4.5-6, but still in the neutral pH range (pH ± 7). Antioxidant activity of the cream has a large reduce power at the first day DPPH reduce percent value for F1, F2, and F3 are 80,73%, 83,05% and 83,51% respectively, while after the storage at the 28th days DPPH reduce percent value for F1, F2, and F3 are 80,43%, 82,49% and 79,02% respectively. Preparation creams that fill physical quality cream is F1 by using emulsifier triethanolamine and stearic acid with a concentration of 8%: 2%
17
Purwaningsih, Neneng Sri, Siti Novy Romlah, and Ayu Choirunnisa. "Literature Review Uji Evaluasi Sediaan Krim." Edu Masda Journal 4, no. 2 (2020): 108. http://dx.doi.org/10.52118/edumasda.v4i2.102.
Full textAbstract:
The format of preparation cosmetic in a cream form is still popular in Indonesia, especially for the women. Because its easier to applied, and more comfortable. Literature review of evaluation cream preparation test is to compare the results of cream evaluation preparation from the previous researches, in order to get the best test results and accordance with specified conditions. The general purpose of this research is to know the results of Literature review of evaluation cream preparation test from several journals. Method This research is qualitative research which is Library research Cream evaluation preparation is a Parameters that have been established to determine the stability of cream preparation including organoleptic test, pH test, homogeneity test, type cream test, viscosity test, and scattering test. From the result of organoleptic test, pH test, viscosity test and scattering test review have the results partial test standards, and some doesn’t. this is due to the temperature factor, excessive extract concentration and chemical reaction at the time of storage is accelerated. Whereas at the results of homogeneity test have a quite good homogeneity, and in a type cream test has A/M and M/A type cream.
18
Sertin Prilda Sari Sandoro, Suprianto, and Sumardi. "Formulation of Coconut Shell Activated Charcoal Eyebrow Cream." Jurnal Indah Sains dan Klinis 2, no. 2 (2021): 12–17. http://dx.doi.org/10.52622/jisk.v2i2.26.
Full textAbstract:
Eyebrow cream (EC) is one of the decorative cosmetics applied to the eyebrows using a brush for the purpose of giving color and emphasizing the shape of the eyebrows. EC is one of the practical preparations to fill in empty eyebrow hairs. The research was conducted of formulating activated charcoal into EC. The research method includes the formulation and evaluation of EC results from coconut shell activated charcoal at concentrations of activated charcoal 1%, 3%, 5% and 7%. Evaluation includes: organoleptic, homogeneity, irritation and pH of Eyebrow Cream. The organoleptic showed that the color of the preparation at a concentration of 1% -7% was black to dark black, with a cocoa oleum aroma, and a semi-solid texture. The pH of the preparation is 4.5-6.5 with good homogeneity. The preparation did not show irritation to the skin of volunteers. The study provide information that activated charcoal can be formulated into EC preparations. Coconut shell activated charcoal can be formulated in the form of eyebrow cream. The preparation of eyebrow cream does not cause irritation and is safe.
19
Tampubolon, Antetti. "FORMULASI SEDIAAN CREAM BLUSH ON MENGGUNAKAN EKSTRAK BUNGA MAWAR MERAH (Rosa damascena P.Mill) SEBAGAI PEWARNA ALAMI." Jurnal Riset Kefarmasian Indonesia 6, no. 2 (2024): 249–61. http://dx.doi.org/10.33759/jrki.v6i2.524.
Full textAbstract:
Blush on is a form of cosmetic preparation, aiming to give color to the cheeks and dimensions to the face. The purpose of this study was to determine the possibility of red rose extract (Rosa damascena P. Mill.) to be formulated as a blush on cream preparation, and the effective concentration to fulfill physical tests and evaluations. This research is an experimental study. Data collection was carried out through the formulation of blush on cream with the addition of red rose flower extract in a concentration combination of 10%, 20% and 30%. Then organoleptic test, stability test, pH test, topical test, irritation test, and hedonic test were carried out. Through research it is known that the preparation of blush on cream from red rose flower extract: fulfills the physical evaluation test and stability test; while the hedonic test at concentrations of 0% and 10% were included in the preferred category, and preparations at concentrations of 20% and 30% were included in the very preferred category by the panelists. The conclusion of this study is that cream blush from red rose flower extract is able to produce preparations that meet physical tests and evaluations; and can be formulated as a natural dye in blush on cream preparations that produce pale pink, intense pink, and intense red colors. The higher the concentration of the extract, the darker the resulting color.
20
Gavali, Akshay S. "Preparation and Evaluation of Cream Containing Betel Leaf Extract for Removal of Cutaneous Warts." International Journal for Research in Applied Science and Engineering Technology 12, no. 6 (2024): 2328–38. http://dx.doi.org/10.22214/ijraset.2024.63486.
Full textAbstract:
Abstract: Warts are common skin growths caused by the human papillomavirus (HPV). They can appear on any part of the body but are most commonly found on the hands, feet, and genitals. Warts are usually harmless but can be unsightly or cause discomfort, especially if they are frequent friction or pressure. There are several types of warts, including common warts, plantar warts (on the soles of the feet), genital warts, and flat warts (often found on the face). Creams are semisolid dosage form containing one or more drugs substances dissolved or dispersed in a suitable base. They are emulsion of either W/O, O/W creams are uses for various purposes. Wart removal cream contains some synthetic substances as well as herbal ingredients like betel steam which is having antiviral activity against the human papilloma virus (HPV). Then calcium carbonate and sodium hydroxide slowly absorbed into the skin causing rupturing of the skin cells that contains the wart virus. To prepare wart removal cream sodium hydroxide and calcium carbonate along with the aqueous extract of betel leaf by maceration with the excipients such as stearic acid, glycerin, methyl paraben, distilled water are used. Finally, the cream is evaluated with various parameters such as physical and chemical properties like pH, viscosity, spreadability, texture. As this cream has clove oil which is used as an analgesic to avoid the irritational pain. The pH of the cream is supposed to be basic and around 12-12.5. During the evaluation the pH of the cream was found out to be 12.1. Cream was easily spreadable and it had a pleasant appearance.
21
Ghildiyal, Himani, Shubham Raj, and Rahul kuwar. "Formulation and Evaluation of Herbal Face Cream." International Journal of Pharmaceutical Research and Applications 09, no. 05 (2024): 42–48. https://doi.org/10.35629/4494-09054248.
Full textAbstract:
Herbal creams are mainly intended for beautification of skin. The main aim of the present research work is to prepare a face cream using different herbs and the prepared cream is evaluated for stability and anti bacterial activity. The herbs used in the formulation (F1, F2, and F3) are flowers of Jasmine, Tulsi, leaves of Neem. The formulated cream is evaluated for the various parameters like organoleptic properties, pH, stability, consistency, skin irritation, and antibacterial properties. F1 formulation has shown good stability and antibacterial properties compared to marketed cream. Aloe vera. Jasmine, Neem, Tulsi are medicinal plant they are used as traditionally from ancient year in various herbal medicines such Ayurveda, siddha, and Homeopathic. Cosmetic and some medicinal products are made up from the Mucilaginous tissue in the centre of aloe vera leaf and called Aloe vera gel. The herbal cream is basically water in oil type of emulsion. The natural ingredients chosen for preparation of herbal cream are turmeric, Jasmine, aloe-vera, Tulsi, and neem. The choice of these ingredients is based on their individual properties.
22
Husnani, Husnani, and Fitri Sri Rizki. "FORMULASI KRIM ANTIJERAWAT EKSTRAK ETANOL BAWANG DAYAK (Eleutherina palmifolia (L.) Merr)." JIFFK : Jurnal Ilmu Farmasi dan Farmasi Klinik 16, no. 01 (2019): 8. http://dx.doi.org/10.31942/jiffk.v16i01.2923.
Full textAbstract:
ABSTRACTDayak onion contains alkaloid compounds, flavonoids, saponins, tannins, glycosides, and triterpenoids which have anti-acne effects. This study aims to make cream formulas from Dayak onion ethanol extract and evaluate the physical quality characteristics of cream. The cream formulation from dayak onion extract was made with extract concentration of 100 mg/ml with stearic acid and triethanolamine as emulgator. Stearic acid and triethanolamine concentrations used were FI (6%: 2%), FII (12%: 3%), FIII ( 18%: 3%). The creams were evaluated for its physical quality characteristics, namely organoleptic, homogeneity, pH, dispersion, cream type and viscosity. From the evaluation of physical quality characteristics, it can be concluded that Formula III is the best formula that meets good cream quality requirements. The Dayak onion ethanol extract cream is an O/W type cream resulting in semi-solid, brown, organoleptic and dayak onion odor. In the homogeneity test there is no clumping on the cream preparation so that the preparation is homogeneous. The pH value is 6, so the cream is safe for the face. The spreadability of FIII is 7.52 cm, meets the requirements. The viscosity of F III is 32000 cPs, meets the requirements of a good cream preparation viscosity.Keywords: Formulation, Cream, Dayak Onion Extract (Eleutherine palmifolia (L.) Merr).
23
Farda, Zais, Titi Pudji Rahayu, and Naelaz Zukhruf Wakhidatul Kiromah. "Formulation and Physical Evaluation of Papaya Leaf (Carica papaya L.) Ethyl Acetate Fraction Cream Preparation as Anti Acne Against Propionibacterium acne Bacteria." Jurnal Pijar Mipa 19, no. 2 (2024): 295–301. http://dx.doi.org/10.29303/jpm.v19i2.6146.
Full textAbstract:
Acne or acne vulgaris is a disease in the form of inflammation of multiple sebaceous glands caused by the bacteria Propionibacterium acne. Papaya leaves are a plant that can potentially be used as an acne treatment. To determine the antiacne activity of papaya leaf ethyl acetate fraction cream preparations caused by Propionibacterium acne bacteria. The ethyl acetate fraction of papaya leaves are made into a cream preparation with varying concentrations of ten, fifteen, and twenty percent. The results of the cream preparation test met the physical property standards. Still, the viscosity in formulation three did not meet the standards, and formulas two and three did not meet the cream stability test standards. Antibacterial tests show that all formulas have inhibitory power against bacteria. The average inhibition zone results in formula one, formula two, and formula three were 4.99 ± 0.48 mm, 6.85 ± 0.48 mm and 10.12 ± 1.42 mm. Formula One papaya leaf fraction cream fulfills all the physical characteristics of the preparation. All papaya leaf ethyl acetate fraction cream preparations are antibacterial against Propionibacterium acne. So, research can be developed using the ethyl acetate fraction of papaya leaves in various preparations, and activity tests against other bacteria can be carried out.
24
Kumar, Sagar1* Painuly Neelam2. "Formulation And Evaluation Of Herbal Analgesic Cream." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 258–69. https://doi.org/10.5281/zenodo.12657970.
Full textAbstract:
Herbal analgesic creams offer a promising avenue for natural pain relief, leveraging the therapeutic properties of botanical ingredients. This formulation is developed using standard formulation of herbal analgesic cream, each varying in the ratio of key ingredients to optimize efficacy. Turmeric, ginger, arnica, lemon balm, and liquorice were selected for their well-documented analgesic and anti-inflammatory properties. The formulations were prepared using a meticulous process, ensuring the integration of active ingredients with suitable excipients for stability and skin compatibility. The method involved the preparation of herbal extracts followed by the formulation of the cream using a double boiler technique. Additional ingredients such as glycerine, methyl paraben, zinc oxide, and rose oil were incorporated to enhance moisturization, preservation, and aroma. The resulting creams were then subjected to comprehensive evaluation to assess their physical properties, stability, irritancy, spreadability, phase separation, and pH. All formulations exhibited a mustard colour with a semi-solid appearance and emitted a characteristic herbal aroma, indicating uniformity in preparation. Stability testing revealed that the creams remained stable over a four-week period, with no observable degradation. pH measurements ranged slightly acidic to slightly alkaline, with all formulations falling within acceptable ranges for skin compatibility. Irritancy tests confirmed the creams' non-irritant nature, indicating their safety for topical application. Spreadability tests demonstrated acceptable ease of application, suggesting practicality in use. Furthermore, all formulations showed no signs of phase separation, affirming homogeneity in composition. These findings collectively highlight the robustness and efficacy of the developed herbal analgesic creams. The formulations F1, F2, and F3 of the herbal analgesic cream exhibit promising characteristics in terms of physical properties, stability, skin compatibility, and efficacy. While all formulations performed well across various evaluation parameters, formulation F3 stood out for its slightly higher pH, which may be a consideration for specific preferences or requirements. Overall, this study underscores the potential of herbal analgesic creams as safe and effective alternatives for managing pain and inflammation, paving the way for further exploration and development in natural therapeutics.
25
Manisha, U. Mishra *. Aishwarya A. Jain Prachi S. Patle Pratibha U. Thakur Priyanshi A. Ramteke Riya A. Jaitwar Pratiksha I. Damahe. "Creation And Evaluation Of Multi Herbal Fairness Cream By Using Carica Papaya And Phyllanthus Emblica." International Journal in Pharmaceutical Sciences 2, no. 7 (2024): 579–63. https://doi.org/10.5281/zenodo.12700090.
Full textAbstract:
The present study was carried out to prepare and evaluate the herbal fairness cream comprising extracts of Aloe barbadensis ,curcuma longa, emblica officinalis,Ocimum sanctum and papaya oil. The various types of formulations oil in water (O/W) base were formulated by incorporating different concentrations Stearic acid and Cetyl alcohol. And different concentration of methyl paraben into the water and glycol in different amount. The pH, viscosity, spreadibilty, and stability of prepared base were investigated. The base was found appropriate for the preparation of cream. The extracts of varying ratio of turmeric , amla , aloe vera and Tulsi were incorporated in base for the preparation of multiherbal fairness cream the herbal cream demonstrated good spreadibilty, good consistency, homogeneity, appearance, pH, irritancy, Wahsability, Homogeneity, Anti-inflammatory,Anti-microbial ease of removal and no evidence of phase separation. All the prepared herbal cream was found to be safe for skin. Mostly people use whitening creams to improve their complexion. Melanin plays main role in the skin colour and pigmentation. The tyrosinase catalyzes melanin synthesis, tyrosinase inhibitors are important in cosmetic skin-whitening. The aim of present study was to formulation and development of whitening poly herbal face cream comprising extracts.
26
Deepali, S. Suryavanshi* Ajit Ashok Naik Anjum Gafar Bairagdar Aditi Rajgonda Patil Snehal P. Bongarde. "Pharmaceutical Preparation And Evaluation Of Herbal Cold Cream." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 663–69. https://doi.org/10.5281/zenodo.11611992.
Full textAbstract:
cold cream is used for deep moisturization and allow to remove waste substance from pores and cools the body. Herbal cold cream involve the pure and natural ingredient without any additives in their preparation. The aim of project is Pharmaceutical Preparation and Evaluation of Herbal Cold Cream. Herbal ingredients such as Mint, Honey, Coconut oil, Turmeric powder, Rose water etc are used. All ingredients have any specific property to protect skin from any harmful effect. Main herbal ingredient is Mint because mint have specific cooling effect. To evaluate cream different evaluation parameter used such as Irritation test, Physical evaluation, Washability, pH, Spread ability test etc. Herbal cold cream provide significant effect to the skin.
27
T.Pradeepa, T. Pradeepa, Dr S. Ganesan Dr S.Ganesan, Dinesh G. Dinesh G, et al. "Preparation and Evaluation of Polyherbal Cream." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 1381–87. https://doi.org/10.35629/4494-100213811387.
Full textAbstract:
These formulations can be evaluatedby various parameters like pH, viscosity, irritancy, spreadability, microbial growth, thermalstability, homogeneity, acid value, saponification value, accelerated stability studies, patch test,smear test, after feel, washability, physical properties, etc. Chemical based cosmetics are harmful to the skin and an increased awareness amongconsumers for herbal products triggered the demand for natural products and natural extracts incosmetics preparations. The increased demand for the natural product has created new avenues incosmeceutical market. The natural content in the botanicals does not cause any side effects onthe human body; instead enrich the body with nutrients and other useful minerals.
28
Imrana, siddiqua, khatoon Umaima, nathiq Ali Syed, and Koneru Dr.Anupama. "Preparation and Evaluation of Herbal Cold Cream with Incorporated Curcuma longa." International Journal of Innovative Science and Research Technology 7, no. 3 (2022): 974–76. https://doi.org/10.5281/zenodo.6433887.
Full textAbstract:
To formulate and evaluate herbal cream cold cream using Turmeric to give glowing & cooling effect. Methods: The cream was prepared by using the cream base that is bee’s wax, liquid paraffin, borax, distilled water, rose oil.The cream was prepared by using the slab technique/extemporaneous method for geometric and homogenous mixing of all the excipients and the herbal extracts. Cream Was prepared & was evaluated for different parameters like appearance, PH, viscosity, stability dest, patch test, test for homogeneity, spread ability, smear test, evaluation of Emolliency & Test for microbial growth. Results: the cream showed good appearance, PH, adequate viscosity and no phase separation was observed. Also, the formulation showed no redness, erythema and irritation during patch study and they were easily washable was stable at room temperature. Conclusion: Herbal ingredient showed significant results, we can suggest that the cream was stable and can be safely used on the skin.
29
Kirana, Bida Cincin, Erlien Dwi Cahyani, and Antonius Budiawan. "Protective Factor Evaluation of Purslane (Portulaca grandiflora) Magenta Flower Variety Herbs Extract Cream Formula." JURNAL FARMASI DAN ILMU KEFARMASIAN INDONESIA 10, no. 3 (2023): 379–85. http://dx.doi.org/10.20473/jfiki.v10i32023.379-385.
Full textAbstract:
Background: Indonesia is an equatorial country that is rich in sunlight all year. UV light is divided into three wavelength groups: UV-A (320-400nm), UV-B (280-320nm), and UV-C (100-290nm). Intracell chromophores in skin cell membranes such as riboflavin, porphyrin, nicotinamide, and enzymes will absorb the UV-A light. The UV-B light penetrates the dermis layer and causes DNA structure changes, which lead to wrinkles and a rising risk of skin cancer. Premature skin aging and skin cancer can be prevented with sunscreen preparation containing compounds that can protect the skin from UV radiation. Flavonoid is one of the purslane (Portulaca grandiflora) active metabolites that have the potency to be developed as sunscreen. Objective: This research aimed to determine the ability of purslane (Portulaca grandiflora) magenta flower variety herbs extract cream as a sunscreen as indicated by the %Te, %Tp, and Sun Protective Factor value. Methods: This research was an experimental study with various purslane magenta flower variety herbs extract cream formulas that were tested for their %Te, %Tp, and SPF value with a UV-Vis spectrophotometer. Results: The sunscreen cream preparation with 2.5% of purslane (Portulaca grandiflora) magenta flower variety herb extract had %Te, %Tp, and SPF values of 25.86 ± 2.41%, 36.05 ± 2.82%, and 3.97 ± 0.35 respectively. At the same time, preparations with 5% concentration of extract had %Te, %Tp, and SPF values of 8.23 ± 0.86%, 16.65 ± 0.92%, and 8.03 ± 0.38, respectively. Conclusion: The sunscreen activity of all extract concentration creams was significantly different compared to the negative control (cream base) in all parameters. Flavonoids are the compounds responsible for the sunscreen activity of purslane extract.
30
Awalludin, Awalludin, Robert Tungadi, and Endah Nurrohwinta Djuwarno. "Formulasi dan Evaluasi Stabilitas Fisik Krim Minyak Biji Kelor (Moringa oleifera L.)." Journal of Experimental and Clinical Pharmacy (JECP) 2, no. 2 (2022): 144. http://dx.doi.org/10.52365/jecp.v2i2.433.
Full textAbstract:
Minyak biji kelor merupakan tanaman yang memiliki efek antioksidan karena memiliki kandungan flavanoid yang tinggi, sehingga perlu dilakukan pengembangan minyak biji kelor dalam bentuk sediaan krim. Penelitian ini bertujuan untuk memformulasi serta mengevaluasi sediaan krim. Penelitian ini merupakan penelitian eksperimental laboratorium. Sediaan krim dibuat dengan dengan tiga formula konsentrasi minyak biji kelor yang berbeda yaitu FI (3%); FII (4%); FIII (5%). Evaluasi stabilitas sediaan krim meliputi pengamatan organoleptik (bau, warna, tekstur), uji homogenitas, uji pH, uji viskositas, dan uji daya sebar. Hasil pemeriksaan mutu sediaan organoleptik menunjukkan bahwa semakin tinggi konsentrasi dalam sediaan krim maka semakin kental pula sediaan tersebut, uji homogenitas sediaan menunjukkan susunan yang homogen, uji pH yang dihasilkan 5,8-6,1, uji viskositas sediaan yang dihasilkan 5900 Cp, 5300 Cp, dan 5240 Cp, dan uji daya sebar yang dihasilkan 7 cm, 6,5 cm, 5,5 cm. Maka dapat disimpulkan bahwa FI, FII dan FIII krim minyak biji kelor dapat diformulasikan sebagai sediaan krim.Moringa seed oil is a plant that has an antioxidant effect because it has a high flavonoid content, so it is necessary to develop Moringa seed oil in the form of cream preparations. This study aims to formulate and evaluate cream preparations. This research is an experimental laboratory research. Cream preparations were made with three different concentration formulas of Moringa seed oil, namely FI (3%); FII (4%); FIII (5%). Evaluation of the stability of the cream preparation included organoleptic observations (smell, color, texture), homogeneity test, pH test, viscosity test, and spreadability test. The results of the quality inspection of organoleptic preparations showed that the higher the concentration in the cream preparation, the thicker the preparation, the homogeneity test of the preparation showed a homogeneous arrangement, the pH test produced was 5.8 -6.1, the viscosity test of the preparation produced 5900 Cp, 5300 Cp , and 5240 Cp, and the resulting dispersion test was 7 cm, 6.5 cm, 5.5 cm. So it can be concluded that FI, FII and FIII Moringa seed oil cream can be formulated as a cream preparation.
31
Rahmiyani, Ira, Wulan Novian Dewi, Anindita Tri Kusuma Pratita, and Resha Resmawati Shaleh. "FORMULASI KRIM EKSTRAK BIJI KUPA (Syzygium polycephalum) DAN PENENTUAN NILAI SPF (Sun Protection Factor) SECARA IN VITRO." Jurnal Ilmiah Ibnu Sina (JIIS): Ilmu Farmasi dan Kesehatan 7, no. 2 (2022): 328–39. http://dx.doi.org/10.36387/jiis.v7i2.984.
Full textAbstract:
The high intensity of ultraviolet rays and exposure to the sun too often can have harmful effects on the skin, so sunscreen can be used to prevent interference from UV rays. The purpose of this study was to determine the activity of sunscreen and determine the SPF value of the extract and cream preparation of Kupa (Syzygium polycephalum) seeds. In this study, the seeds of Kupa fruit were extracted by the graded maceration method using 96% ethanol, ethyl acetate, and n-hexane as solvents. The ethyl acetate extract was formulated in the form of a cream dosage form with the added concentration of Kupa seed extract, namely 0.1% (F1), 0.2% (F2), and 0.5% (F3). Furthermore, the determination of the value of sunscreen on the extract and cream preparation using UV-Vis spectrophotometry and evaluation of the physical properties of the cream preparation include organoleptic tests, homogeneity, pH tests, spreadability, adhesion, and viscosity. The results showed that the SPF values ??of ethanol, ethyl acetate, and n-hexane extracts at a concentration of 200 ppm were 14.29; 19.32, and 14.02. While the SPF value of ethyl acetate extract cream preparations of Kupa fruit seeds F1, F2, and F3 respectively was 1.97; 2.96, and 4.96. Kupa seed extract has activity as a sunscreen with maximum and ultra protection levels. While the preparation of 0.5% ethyl acetate extract of Kupa seed had sunscreen activity with moderate protection. The physical properties of the cream preparations gave good results during the test.
32
Bui, Dac-Thang, Minh-Tuan Bui, and Ngoc-Van Nguyen Thi. "Optimization formula and evaluation of polyherbal cream for antimicrobial and wound healing activity." Journal of Multidisciplinary Sciences 6, no. 2 (2024): 35–44. https://doi.org/10.33888/jms.2024.625.
Full textAbstract:
The aim of the research is to develop a preparation formula and evaluate the antibacterial and wound healing capabilities of the product polyherbal cream. The optimal ratio of ingredients polyherbal cream formulation was found by testing the antibacterial properties based on the evaluation of the diameter of the antibacterial zone of different bacterial strains and evaluating the acute toxicity and wound healing ability of polyherbal cream in a mouse model. The research has produced the optimal formulation of polyherbal cream, which includes tamanu oil, tea tree essential oil, and cajeput essential oil at concentrations of 28%, 1%, and 9%, respectively, along with excipients such as hydroxyethyl acrylate (1 g), PEG-600 stearate (3.95 g), and cetyl alcohol (5.45 g) in a 100 g preparation. Polyherbal cream determined the acute skin toxicity dose on mice greater than 2000 mg/kg and evaluated the wound healing ability of the preparation. A formula for the preparation of polyherbal cream has been developed and tested for its antibacterial and wound healing effects, contributing to orienting further research on the beneficial pharmacological effects of products made from tamanu (Calophyllum inophyllum), cajeput (Melaleuca quinquenervia), and tea tree (Melaleuca alternifolia) in Vietnam.
33
Rizal, Rosiana, Salman Salman, and Dini Yulanda Putri. "Formulasi Sediaan Lip Cream Dari Ekstrak Etanol Daun Bayam Merah (Amaranthus Tricolor L.) Sebagai Pewarna Alami Bibir." Jurnal Penelitian Dan Pengkajian Ilmiah Eksakta 4, no. 1 (2025): 82–90. https://doi.org/10.47233/jppie.v4i1.1819.
Full textAbstract:
Cosmetics are used to beautify themselves with the intention of adding to their add attraction to be more liked. One of the cosmetics favored by women is lip color, such as lip cream. The application of color is very important to improve the quality of lip cream preparation. A plant that has a dye, namely red spinach (Amarantus tricolor L.) in the form of betacyanin at 0,085%. Apart from being a dye, red spinach also has antioxidant activity which can be seen at the IC50 value 29,76 µg/ml (>50 µg/ml). The purpose of this study was to determine whether the ethanol extract of red spinach leave with concentration of 5%, 10% and 15% could be formulated in lip cream preparations according to the requirements of the evaluation of the preparation (pH test, homogeneity, spreadability, adhesion, stability and irritation test) and to determine the effect of the concentration of red spinach ethanol extract in the preparation. The result showed that the lip cream preparation F0 (without extract), F1 (5%), F2 (10%) and F3 (15%) were stable and evenly dispersed during unform storage. The difference in the concentration of the ethanol extract of red spinach leaves affects the color of the preparation, namely white (F0), pink (F1), brick red (F2) and dark red (F3). The higher the concentration of the extract, the darker the color and the more acidic the pH of the preparation. In the evaluation the preparations, it was found that the pH test was according to the skin range, adhesion and spreadability met the requirements and was not irritating. The result of the preference test found that the best preparation was F2 as much as 28%.
34
Mustarichie, Resmi, and Dolih Gozali. "FORMULATION AND EVALUATION OF ALPHA ARBUTIN SKIN LIGHTENING CREAM USING POLYACRYLATE BASE BY COLD PROCESS." International Journal of Applied Pharmaceutics 11, no. 1 (2019): 100. http://dx.doi.org/10.22159/ijap.2019v11i1.29393.
Full textAbstract:
Objective: The objective of this research was to formulate and evaluate alpha arbutin skin lightening cream using polyacrylate base by cold process.Methods: Five formulas of alpha arbutin skin lightening cream were prepared with Polyacrylate Base with different polyacrylate concentrations as a cream base for each formula. The various concentrations of polyacrylate (2, 3, 4, 5, and 6%) was used as a cream base. The resulting preparation was then examined and observed for consistency, color, odor, and stability for 28 d of storage.Results: The phase separation test results stated that the five cream formulas did not experience phase separation in 2500, 3000, and 3750 rpm centrifugations so that it could be concluded that the five cream formulas were stable in storage at room temperature for at least 12 mo. From the physical evaluation of cream preparations, it was found that the cream formula with 6% polyacrylate concentration gave the best stability results. Cream safety testing results stated that the cream did not irritate the skin of the wearer.Conclusion: The results obtained in this research work clearly indicated alpha arbutin cream can be formulated using polyacrylate as a cream base, and in its manufacture, it can be carried out with a cold process.
35
Gangurde, Avinash B., and Suraj Pagar. "Preparation and evaluation of antibacterial mupirocin cream emulsion using cocamidopropyl betaine emulsifier." Journal of Applied Pharmaceutical Research 12, no. 6 (2024): 215–24. https://doi.org/10.69857/joapr.v12i6.633.
Full textAbstract:
Background: This study aimed to develop and evaluate an antibacterial cream emulsion containing mupirocin using Cocamidopropyl betaine (CAPB) as an emulsifier. Mupirocin, a topical antibiotic effective against Staphylococcus aureus (including methicillin-resistant strains), was formulated into a cream to enhance its topical delivery. Materials and Methods: Mupirocin cream emulsion formulations were developed with varying concentrations of CAPB, PEG-400, and glycerol monostearate. The cream formulations were mainly evaluated for in vitro diffusion tests, antibacterial activity tests, and stability studies. Result and Discussion: CAPB produced a stable cream emulsion formulation (F7) at 30% concentration and 2% PEG-400. The formulation (F7) exhibited sustained drug release over 3.5 hours in the diffusion test. The formulation F7 showed a higher zone of inhibition, 32.16±2.2 mm, than the marketed mupirocin cream, 29.56±1.35 mm, for the Staphylococcus aureus strain. The prepared cream formulation F7 was found stable over 90 days at different temperature conditions (8±2°C, 25±2°C and 40±2°C). Conclusion: The study concludes that CAPB effectively enhances mupirocin cream solubility and antibacterial properties, making it a promising option for treating bacterial skin infections.
36
B Chaudhari Manjusha, Nilesh. "Preparation and Evaluation of Antimicrobial Cream Containing Herbs from Local Habital Plants." International Journal of Science and Research (IJSR) 13, no. 4 (2024): 905–9. http://dx.doi.org/10.21275/mr24408110803.
Full text
37
Mukund, Agarwal, Goyal Bhola, Goyal Rakesh, Bansal Mukesh, and Bhaduka Gaurav. "Cream: A Review on Method of Preparation, Extraction and Evaluation." Pharmaceutical and Chemical Journal 9, no. 6 (2022): 43–46. https://doi.org/10.5281/zenodo.13981776.
Full textAbstract:
Cosmetics are the preparations which used to beautify and enhance the human appearances. The aim of the present research was to formulate and evaluate the aloe cold containing plant extracts prepared by using water in oil (Emulsification method) method for the purpose of nourishing and moisturizing the skin. The cold cream is prepared by using the rose oil and extract of aloe vera. Quality evaluation of the formulated product was assessed by using different evaluation methods. No change of the physical properties was observed in formulated cream. The formulated cream showed good consistency and spread ability, pH, no evidence of phase separation during study period of research. Stability parameters like visual appearance, nature, viscosity and fragrance of the formulated cream showed that there was no significant variation during the study period of research.
38
Aman, Shaikh Tejashree kedar Abubakar Shaikh Sohel Shaikh Naziya pathan. "Formulation And Evaluation Of Multipurpose Herbal Cream." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 1327–34. https://doi.org/10.5281/zenodo.12583271.
Full textAbstract:
Herbal cold cream are semi solid preparation used for the complexion of the face, enhance the appearance The main aim to this research work to prepare a herbal cold cream from using different herbs and prepare a herbal face cream to evaluate the efficacy The formulated herbal cold cream is evaluated for the various parameters like organoleptic properties, pH, stability, consistency, homogeneity and appearance. Herbal cosmetics are products that are used to enhance one's look. The goal of the research was to develop a herbal cold cream for moisturizing, nourishing, enhancing whitening, and treating various skin diseases. Curcu-ma longa (Turmeric powder), cucumber extract, Aloe barbadensis (Aloe-vera leaves), and Ocimum sanctum (Tulsi leaves) are some of the basic herbs used to make the herbal cold cream. The selection of components is based on various therapeutic characteristics.
39
Duha, Idarwati, and Adek Chan. "Cream Formulation of Ethanol Extract of Banana Peel (Musa Paradisiaca Var. Sapientum (L))." Jurnal Dunia Farmasi 1, no. 1 (2019): 22–29. http://dx.doi.org/10.33085/jdf.v1i1.4348.
Full textAbstract:
Introduction: Musa Paradisiaca Var. Sapientum (L) or know as the banana plants in Indonesia is a herbaceous plants that belongs to the family Musaceaa. Objective: This Study Aims tho determine the rind of banana (Musa Paradisiaca Var. Sapientum (L)) can be formulated in Cream.Methode: This research the conducted experimental, the sample is extracted by maceration using 70% ethanol. Extract later in pekatkan at temperatrs 400C with a pressure of 100 atm. Viscous extract obtained of used at an concentration of 5%, 10% and 15%. Results: Results showed that banana peel extract can be prepared as a cream and meet the pyshical Evaluation of the stocks. Homogeneity test result that the preparation made sufficiently homogeneous, pH 6.5 to 6.9 is obtained cream still meet the skin’s Ph ranging between 6.0 to 7.0 and cream type test. Colculsion: Dosage formulations cream bark ethanol extract banana (Musa Paradisiaca Var. Sapientum (L)) qualified physical evaluation preparations include homogeneity, pH test dan thest type cream.
40
Lu, Zhen, Qing Guo Tang, Jin Sheng Liang, and Yan Ding. "The Preparation and Effect Evaluation of Natural Mineral Skin-Care Cream." Advanced Materials Research 427 (January 2012): 230–35. http://dx.doi.org/10.4028/www.scientific.net/amr.427.230.
Full textAbstract:
In this work, purified and surface-pretreated attapulgite was added to the common recipe of the skin-care cream and the improved cream products, containing clay minerals, were prepared. In order to optimize the moisturizing and sunscreen properties of the cream products, different attapulgite addition was tried and the grinding time of the attapulite was considered. The result shows that, by adding attapulgite clay, the moisturizing and sunscreen properties of the skin-care products can be improved respectively.
41
Ayuningsih, Qurotha, Anita Dwi Septiarini, and Weri Veranita. "Formulasi dan uji aktivitas antioksidan sediaan hand body cream ekstrak kulit pisang emas menggunakan metode FRAP." Pharmasipha : Pharmaceutical Journal of Islamic Pharmacy 7, no. 2 (2024): 11–26. http://dx.doi.org/10.21111/pharmasipha.v7i2.9979.
Full textAbstract:
ABSTRACT Antioxidants are chemical compounds that, in certain amounts, can reduce or slow down damage caused by free radical oxidation processes. The content of compounds that have the potential as antioxidants is golden banana skin (Musa acuminata). This study aims to find out whether golden banana peel extract can be formulated into hand and body cream, whether the hand and body cream formulation of golden banana peel extract meets the requirements for good preparation evaluation, and whether the formulation of hand and body cream preparation with golden banana peel extract has antioxidant activity by the FRAP method. This research is a laboratory experimental research conducted by collecting and identifying plant materials and simplicia characteristics, making extracts, testing the correct antioxidant levels in the dosage formulations, and conducting antioxidant activity tests for hand and body cream preparations of golden banana peel extract using the FRAP method. The test results of the golden banana peel (Musa acuminata) can be formulated into hand and body cream preparations, with the best results in formulation 5, which consists of 3% extract with an average antioxidant activity value of 86.118 mgAAE/gram, which indicates the formulation of hand and body cream extract preparations. Mas banana peel has antioxidant activity with the FRAP method. The formulation of hand and body cream preparations with golden banana peel extract can meet the evaluation requirements for good hand and body cream preparations. Keywords: Antioxidants, Golden Banana Peel, Hand and Body Cream ABSTRAK Antioksidan adalah senyawa kimia yang dalam jumlah tertentu dapat mengurangi/ memperlambat kerusakan akibat proses oksidasi radikal bebas. Kandungan senyawa yang berpotensi sebagai antioksidan yaitu kulit pisang emas (Musa acuminata). Penelitian ini bertujuan untuk mengetahui apakah kulit pisang emas dapat diformulasikan menjadi hand and body cream, untuk mengetahui apakah formulasi sediaan hand and body cream ekstrak kulit pisang emas memenuhi syarat evaluasi sediaan yang baik serta mengetahui apakah formulasi sediaan hand and body cream ekstrak kulit pisang emas memiliki aktivitas antioksidan dengan metode FRAP. Penelitian ini merupakan penelitian eksperimen laboratorium dengan melakukan pengumpulan serta identifikasi bahan tumbuhan, karakteristik simplisia, pembuatan ekstrak, pengujian kadar antioksidan yang tepat dalam formulasi sediaan serta melakukan uji aktivitas antioksidan sediaan hand and body cream ekstrak kulit pisang emas menggunakan metode FRAP. Hasil pengujian kulit pisang emas (Musa acuminata) dapat diformulasikan menjadi sediaan hand and body cream dengan hasil terbaik pada formulasi 5 yang terdiri dari 3% ekstrak dengan nilai rata-rata aktivitas antioksidan sebesar 86,118 mgAAE/gram yang menandakan Formulasi sediaan hand and body cream ekstrak kulit pisang mas memiliki aktivitas antioksidan dengan metode FRAP. Formulasi sediaan hand and body cream ekstrak kulit pisang emas dapat memenuhi syarat evaluasi sediaan hand and body cream yang baik. Kata kunci: Antioksidan, Kulit Pisang Emas, Hand and Body Cream
42
Rahman, Alief Putriana, Liana, Syaifiyatul H, and Ach Faruk Alrosyidi. "Antioxidant Face Cream Formulation of Ethanol Extract from Soursop leaves (Annona muricata L)." Berkala Ilmiah Kimia Farmasi 10, no. 2 (2023): 34–41. http://dx.doi.org/10.20473/bikfar.v10i2.38479.
Full textAbstract:
Face cream is a treatment cream used to treat facial skin. One of the natural plant ingredients that can be used as an active substance in cream preparations is soursop leaves (Annona muricata L.) which have antioxidant activity. The purpose of this study was to formulate cream preparations from soursop leaf ethanol extract as well as the antioxidant activity of face cream preparations. Soursop leaves were extracted by maceration using a 96% ethanol solvent. Cream preparations in physical quality evaluation include organoleptic, pH, homogeneity, viscosity, spread power, sticking power, centrifugation, determination of emulsion type, and antioxidant activity test with DPPH method at 𝜆 511,5 nm using UV-Vis spectrophotometry. The results that organoleptic cream preparations had color differences. The pH of FI, FII, and FIII creams had an average yield of 6,0-6,6 and were homogeneous. All creams had a viscosity value of 49950 cPs and scatter power at 5,2-5,7 cm. FI, FII, and FIII creams fixed power test with an average value of 26,5-46,5 and physically stable at centrifugation tests with cream emulsion type of O/W. Based on the antioxidant activity, the facial creams of ethanol extract from soursop leaves of FI (3%), FII (5%), and FIII (7%) had IC50 values of 80,64, 46,06, and 10,91 ppm respectively. So this study concluded that the facial cream of ethanol extract from soursop leaves at FI, FII, and FIII meet the physical stability requirements based on organoleptic, pH, homogeneity, viscosity, scatter power, clinging power, centrifugation, and emulsion type tests. FI cream had strong antioxidant activity (IC50 value of 80,64 ppm), then FII and FIII had very strong antioxidant activity (IC50 value of 46,06 and 10,91 ppm. Keywords: Cream, Formulation, Antioxidant, Ethanol extract, Soursop leaves
43
Kalyani, Khairnar* Jitesh Desale Mayur Gangurde. "Formulation And Evaluation Of Herbal Cream Containing Curcumin From Curcuma Longa." International Journal of Pharmaceutical Sciences 2, no. 6 (2024): 727–33. https://doi.org/10.5281/zenodo.11668928.
Full textAbstract:
Curcuma longa commonly called as turmeric belongs to the family of Zingiberaceae and it is derived from the rhizomes. It is well known that curcumin has a good anti-inflammatory properties and a protective effect on the skin. Traditionally, curcumin is incorporated in many natural herbal remedies to treat skin infections and inflammation. Stearic Acid, different quantities of Turmeric Extraction, Cetyl alcohol, Propylene Glycol ,glycerine, Methyl Paraben, Vitamin E, Sodium Lauryl Sulphate, Almond oil, and the necessary amount of distilled water were used to produce the cream. The pH of the skin (6.8–7) was then maintained by adding. The prepared compositions were assessed for skin irritation, Spreadability, pH, and physical appearance. Stability investigations have adhered to ICH recommendations. The purpose of this study to isolate curcumin from Curcuma longa and formulate curcumin containing herbal cream. Result: The current work was completed on the formulation and assessment of the herbal cream. A number of factors are taken into consideration when evaluating cream, including its colour, consistency, pH, Spreadability, viscosity, stability, washability, and skin irritancy test results
44
Jangla, Priyal, Khushboo Merai, Drishti Patel, and Kalyani Sheth. "PREPARATION AND EVALUATION OF BB CONCEALER CREAM CONTAINING NEEM OIL FOR ACNE TREATMENT." INDIAN DRUGS 58, no. 11 (2021): 66–69. http://dx.doi.org/10.53879/id.58.11.12450.
Full textAbstract:
Acne vulgaris is a chronic dermatological inflammatory disease with symptoms like redness, comedones and blemishes appearing on face and neck. Propionobacterium acnes plays an important role in this disease. Neem oil, an ayurvedic, anti-bacterial medicine is non-comedogenic. Concealer is a type of cosmetic used to mask and camouflage blemishes and imperfections visible on skin and are available as liquid, balm, cream and stick. BB creams in cosmetics is termed as “beauty balm, blemish base, blemish balm” designed to serve as foundation, moisturizer and sunscreen all at once. The current study was to develop an aesthetic BB cream combining an anti-acne activity with concealing effect. Concentrations of upto 25 %w/w neem oil was prepared and evaluated for appearance, texture, pH, spreadability, antibacterial properties and in vitro release studies. All the formulations confirmed activity against P. acnes. Prolonged activity of neem oil observed at the end of 6 h as demonstrated in vitro
45
Sameer Shafi and Shendarkar G R. "Optimization And Evaluation Of Polyherbal Topical Cream." International Journal of Research in Pharmaceutical Sciences 12, no. 1 (2021): 940–46. http://dx.doi.org/10.26452/ijrps.v12i1.4522.
Full textAbstract:
Herbal plants and their combination report therapeutic as a well synergistic effect that has been recognized in medicine. So, taking into account this factor, the polyherbal topical cream formulation was prepared by using plant extracts to improve patient compliance, enhance antimicrobial spectrum and enhance aesthetic properties. The study focused on the topical polyherbal cream formulation for delivery of the active constituents present in plants to improve skin diseases. The plant extracts of Ocimum sanctum (OS), Rubia cordifolia (RC), Glycyrrhiza glabra (GG) were utilized for the preparation of cream. The formulated cream was subjected to different evaluation parameters and the results depicted that the spreadability of the formulation was low (17.80 ± 1.10g. cm/sec) and that indicates trouble-free spreading, free from grittiness. In rheological properties all the cream formulations also exhibited the same non-Newtonian behaviour. Polyherbal topical cream showed potential antimicrobial activity against all selected microorganisms. Polyherbal topical cream (PHC-5) was ideal in terms of viscosity than other formulations and showed good drug release. Thus, the formulated polyherbal cream was found to be stable in terms of all physicochemical properties.
46
Rumayar, Ricky C., Paulina V. Y. Yamlean, and Jainer P. Siampa. "FORMULASI DAN UJI AKTIVITAS ANTIJAMUR SEDIAAN KRIM EKSTRAK METANOL KETEPENG CINA (Cassia alata L.) TERHADAP JAMUR Candida albicans." PHARMACON 9, no. 3 (2020): 365. http://dx.doi.org/10.35799/pha.9.2020.30020.
Full textAbstract:
ABSTRACTCandle tree is widely used traditionally as an antiparasitic and antifungal. Candle tree leaves have important ingredients such as alkaloids, saponins, tannins, steroids, anthraquinones, flavonoids. This study aims to formulate, evaluate, and test the antifungal effectiveness of cream preparations with M / A cream types of methanol extract of Candle tree (cassia alata L.) leaves at a concentration of 3.5%; 5.5% and 7.5%. Antifungal effectiveness tests were performed using the diffusion method for creams with the largest antifungal activity. Then the results of testing the effectiveness of the largest antifungal cream was obtained at a concentration of 7.5% with a 9.5 mm diameter of inhibition zone. Physical evaluation of the preparation includes organoleptic test, homogeneity test, pH test, dispersion test, adhesion test, and cycling test. All tests are carried out before and after cyling test. The results of the cream preparation study met the physical evaluation requirements before the cycling test and after the cyling test. Antifungal cream showed organoleptic, homogeneity, pH 8, spreadability test 6.67 cm and adhesion test 27.41 seconds after storage did not change. In conclusions from the study of 3.5% concentration cream; 5.5% and 7.5% methanol extract of Candle tree leaves can be formulated as a cream preparation because it is physically stable and has strong antifungal activity. Keywords: Candle tree (cassia alata L.), Cream, Candida albicans, Antifungal ABSTRAK Ketepeng cina banyak dimanfaatkan secara tradisional, antara lain adalah sebagai antiparasit dan antijamur Daun ketepeng cina memiliki kandungan penting seperti alkaloid, saponin, tannin, steroid, antrakuinon, flavonoid. Penelitian ini bertujuan untuk memformulasi, mengevaluasi, serta menguji efektivitas antijamur sediaan krim dengan tipe krim M/A daun ekstrak metanol ketepeng cina (cassia alata L.) pada konsentrasi 3,5%; 5,5% dan 7,5%. Uji efektivitas antijamur dilakukan dengan metode difusi untuk krim dengan aktivitas antijamur terbesar. Kemudian dilakukan hasil pengujian efektivitas krim antijamur terbesar diperoleh pada konsentrasi 7,5% dengan diameter zona hambat 9,5 mm. evaluasi fisik sediaan meliputi uji organoleptic, uji homogenitas, uji pH, uji daya sebar, uji daya lekat, dan uji cycling test semua pengujian dilakukan sebelum dan sesudah cyling test. Hasil penelitian sediaan krim memenuhi persyaratan evaluasi fisik sebelum uji cycling test dan setelah cyling test. Krim antijamur memperlihatkan organoleptic, homogenitas, pH 8, uji daya sebar 6,67 cm dan uji daya lekat 27,41 detik setelah penyimpanan tidak terjadi perubahan. Kesimpulan dari penelitan pada krim konsentrasi 3,5%; 5,5% dan 7,5% ekstrak metanol daun ketepeng cina dapat diformulasi sebagai sediaan krim karena stabil secara fisik dan memiliki aktivitas antijamur yang kuat. Kata kunci : Ketepeng cina (cassia alata L.), Krim, Candida albicans, Antijamur
47
Aman, Shaikh* Tejashree Kedar Abubakar Shaikh Sohel Shaikh Naziya Pathan. "Formulation And Evaluation Of Multipurpose Herbal Cream." International Journal in Pharmaceutical Sciences 2, no. 6 (2024): 587–94. https://doi.org/10.5281/zenodo.11549296.
Full textAbstract:
Herbal cold cream are semi solid preparation used for the complexion of the face, enhance the appearance The main aim to this research work to prepare a herbal cold cream from using different herbs and prepare a herbal face cream to evaluate the efficacy The formulated herbal cold cream is evaluated for the various parameters like organoleptic properties, pH, stability, consistency, homogeneity and appearance. Herbal cosmetics are products that are used to enhance one's look. The goal of the research was to develop a herbal cold cream for moisturizing, nourishing, enhancing whitening, and treating various skin diseases. Curcu-ma longa (Turmeric powder), cucumber extract, Aloe barbadensis (Aloe-vera leaves), and Ocimum sanctum (Tulsi leaves) are some of the basic herbs used to make the herbal cold cream. The selection of components is based on various therapeutic characteristics.
48
Solanki, Kinjal, Krupa Soni, Divy Raval, Deval Patel, and Yash Prajapati. "Formulation and Evaluation of Novel Multipurpose Herbal Moisturizing Cream." International Journal of Pharmaceutical Research and Applications 10, no. 2 (2025): 691–97. https://doi.org/10.35629/4494-1002691697.
Full textAbstract:
Moisturizing creams are essential for maintaining skin hydration, nourishment, and overall health. Many commercial formulations rely on synthetic ingredients, which may not be suitable for all skin types. To provide a natural and effective alternative, this study focuses on the preparation and evaluation of an herbal moisturizing cream formulated with kojic acid, niacinamide, dandelion extract, aloe-vera extract, cucumber extract, cocoa butter, and beeswax. These ingredients not only enhance skin hydration but also help in skin texture, reducing minor blemishes, protecting against sunburn, reducing acne, and brightening the skin. The formulation was developed using an emulsion-based approach to ensure optimal moisture retention while maintaining a lightweight, non-greasy texture. The presence of kojic acid and niacinamide helps in promoting an even skin tone and reducing acne, while dandelion extract offers mild protection against sun-induced damage. The cream was evaluated for pH, viscosity, spreadability, stability, and occlusivity, with results demonstrating good consistency, hydration efficacy, and formulation stability. This study highlights the potential of herbal-based moisturizing creams as a safer and multifunctional alternative to conventional formulations, offering intense hydration along with skin-brightening, sun protection, and anti-acne benefits.
49
Bhat, Vishnu, Nisha Ullas Naik, Kushal R, et al. "FORMULATION AND EVALUATION OF FOOT CREAM FROM FICUS RACEMOSA." Journal of Pharmaceutical and Scientific Innovation 11, no. 4 (2022): 43–46. http://dx.doi.org/10.7897/2277-4572.114233.
Full textAbstract:
Feet are our body’s substructure, so keeping them healthy is indispensable to our overall health. From ancient time variety of herbs have been used to treat different foot diseases. In this study, the main aim is the preparation of foot cream using Ficus racemosa (cluster fig) plant extract. Its biological active ingredients, such as Gluconal acetate, β-sitosterol, lupeol and lupeol acetate produces wound healing, antioxidant, anti-inflammatory, and anti-fungal activity over skin surface. The main objective of this research work includes the complete qualification of wound healing or screening, and it is useful to obtain good foot cream for topical application. Preparation of foot cream using Ficus racemosa was done and its evaluation was carried out on various parameters. The used product is compatible with other ingredients present in the formulation.
50
Yas, Ali A., and Nidhal K. Marie. "Formulation and Evaluation of Cimetidine as a Topical Preparation." Al Mustansiriyah Journal of Pharmaceutical Sciences 4, no. 1 (2007): 87–101. http://dx.doi.org/10.32947/ajps.v4i1.383.
Full textAbstract:
Cimetidine is a H2 – receptor blocking drug, widely used for the treatment of stomach ulcer in addition to its immune response modifying activity. This study is carried out to formulate cimetidine in a stable topical preparation.The in vitro release of cimetidine from different semisolid bases was studied utilizing: o/w emulsion base A and B, sodium carboxymethylcellulose gel, and w/o emulsion base. The results showed that the best release was obtained from the o/w emulsion base B (i.e. cream base); hence it was selected for extensive studies.The effect of cimetidine concentration on its diffusion through excised mouse skin was also investigated and the data showed an increase in the diffusion rate with increasing cimetidine concentration using cream base. The study also involved the diffusion of the drug from cimetidine 10% w/w cream base through excised mouse skin with different penetration enhancers utilizing: sodium lauryl sulphate, propylene glycol, xanthan gum, oleic acid, methyl salicylate, urea, and PEG1000. The study showed that 3% w/w sodium lauryl sulphate had a very highly significant effect on the diffusion rate of cimetidine. The study also showed that the temperature and the storage period led to a decrease in the diffusion rate, increase in the viscosity of cimetidine 10%w/w cream formula and a little change in the pH. The use of EDTA disodium 1.0%w/w as a stabilizer gave a more stable formula for cimetidine 10% w/w cream formula where the expiration date was 4.09 years compared to 2.74 years when using 1.0%w/w dl – α tocopherol as an antioxidant, and 1.35 years for the blank formula (i.e. formula free from antioxidant and stabilizer).Preliminary clinical study was performed among fifteen patients, ten with warts, and five with adrenal androgenic female – pattern alopecia. The results indicated that 80% of patients with warts gave positive response, while, 40% of patients with adrenal androgenic female – pattern alopecia gave positive response.