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1

Morrey, B. F. "Experimental Knee Pain Reduces Muscle Strength." Yearbook of Orthopedics 2011 (January 2011): 38–39. http://dx.doi.org/10.1016/j.yort.2011.04.131.

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2

Henriksen, Marius, Sara Rosager, Jens Aaboe, Thomas Graven-Nielsen, and Henning Bliddal. "Experimental Knee Pain Reduces Muscle Strength." Journal of Pain 12, no. 4 (April 2011): 460–67. http://dx.doi.org/10.1016/j.jpain.2010.10.004.

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3

Seeley, Matthew K., Jihong Park, Daniel King, and J. Ty Hopkins. "A Novel Experimental Knee-Pain Model Affects Perceived Pain and Movement Biomechanics." Journal of Athletic Training 48, no. 3 (May 1, 2013): 337–45. http://dx.doi.org/10.4085/1062-6050-48.2.02.

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Context: Knee injuries are prevalent, and the associated knee pain is linked to disability. The influence of knee pain on movement biomechanics, independent of other factors related to knee injuries, is difficult to study and unclear. Objective: (1) To evaluate a novel experimental knee-pain model and (2) better understand the independent effects of knee pain on walking and running biomechanics. Design: Crossover study. Setting: Biomechanics laboratory. Patients or Other Participants: Twelve able-bodied volunteers (age = 23 ± 3 years, height = 1.73 ± 0.09 m, mass = 75 ± 14 kg). Intervention(s): Participants walked and ran at 3 time intervals (preinfusion, infusion, and postinfusion) for 3 experimental conditions (control, sham, and pain). During the infusion time interval for the pain and sham conditions, hypertonic or isotonic saline, respectively, was continuously infused into the right infrapatellar fat pad for 22 minutes. Main Outcome Measure(s): We used repeated-measures analyses of variance to evaluate the effects of time and condition on (1) perceived knee pain and (2) key biomechanical characteristics (ground reaction forces, and joint kinematics and kinetics) of walking and running (P < .05). Results: The hypertonic saline infusion (1) increased perceived knee pain throughout the infusion and (2) reduced discrete characteristics of each component of the walking ground reaction force, walking peak plantar-flexion angle (range = 62°–67°), walking peak plantar-flexion moment (range = 95–104 N·m), walking peak knee-extension moment (range = 36–49 N·m), walking peak hip-abduction moment (range = 62–73 N·m), walking peak support moment (range = 178–207 N·m), running peak plantar-flexion angle (range = 38°–77°), and running peak hip-adduction angle (range = 5–21°). Conclusions: This novel experimental knee pain model consistently increased perceived pain during various human movements and produced altered running and walking biomechanics that may cause abnormal knee joint-loading patterns.
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4

Henriksen, Marius, Tine Alkjær, Hans Lund, Erik B. Simonsen, Thomas Graven-Nielsen, Bente Danneskiold-Samsøe, and Henning Bliddal. "Experimental quadriceps muscle pain impairs knee joint control during walking." Journal of Applied Physiology 103, no. 1 (July 2007): 132–39. http://dx.doi.org/10.1152/japplphysiol.01105.2006.

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Pain is a cardinal symptom in musculoskeletal diseases involving the knee joint, and aberrant movement patterns and motor control strategies are often present in these patients. However, the underlying neuromuscular mechanisms linking pain to movement and motor control are unclear. To investigate the functional significance of muscle pain on knee joint control during walking, three-dimensional gait analyses were performed before, during, and after experimentally induced muscle pain by means of intramuscular injections of hypertonic saline (5.8%) into vastus medialis (VM) muscle of 20 healthy subjects. Isotonic saline (0.9%) was used as control. Surface electromyography (EMG) recordings of VM, vastus lateralis (VL), biceps femoris, and semitendinosus muscles were synchronized with the gait analyses. During experimental muscle pain, the loading response phase peak knee extensor moments were attenuated, and EMG activity in the VM and VL muscles was reduced. Compressive forces, adduction moments, knee joint kinematics, and hamstring EMG activity were unaffected by pain. Interestingly, the observed changes persisted when the pain had vanished. The results demonstrate that muscle pain modulated the function of the quadriceps muscle, resulting in impaired knee joint control and joint instability during walking. The changes are similar to those observed in patients with knee pain. The loss of joint control during and after pain may leave the knee joint prone to injury and potentially participate in the chronicity of musculoskeletal problems, and it may have clinically important implications for rehabilitation and training of patients with knee pain of musculoskeletal origin.
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5

Jørgensen, Tanja Schjødt, Marius Henriksen, Sara Rosager, Louise Klokker, Karen Ellegaard, Bente Danneskiold-Samsøe, Henning Bliddal, and Thomas Graven-Nielsen. "The dynamics of the pain system is intact in patients with knee osteoarthritis: An exploratory experimental study." Scandinavian Journal of Pain 6, no. 1 (January 1, 2015): 43–49. http://dx.doi.org/10.1016/j.sjpain.2014.11.002.

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AbstractBackground and aimsDespite the high prevalence of knee osteoarthritis (OA) it remains one of the most frequent knee disorders without a cure. Pain and disability are prominent clinical features of knee OA. Knee OA pain is typically localized but can also be referred to the thigh or lower leg. Widespread hyperalgesia has been found in knee OA patients. In addition, patients with hyperalgesia in the OA knee joint show increased pain summation scores upon repetitive stimulation of the OA knee suggesting the involvement of facilitated central mechanisms in knee OA. The dynamics of the pain system (i.e., the adaptive responses to pain) has been widely studied, but mainly from experiments on healthy subjects, whereas less is known about the dynamics of the pain system in chronic pain patients, where the pain system has been activated for a long time. The aim of this study was to assess the dynamics of the nociceptive system quantitatively in knee osteoarthritis (OA) patients before and after induction of experimental knee pain.MethodsTen knee osteoarthritis (OA) patients participated in this randomized crossover trial. Each subject was tested on two days separated by 1 week. The most affected knee was exposed to experimental pain or control, in a randomized sequence, by injection of hypertonic saline into the infrapatellar fat pad and a control injection of isotonic saline. Pain areas were assessed by drawings on anatomical maps. Pressure pain thresholds (PPT) at the knee, thigh, lower leg, and arm were assessed before, during, and after the experimental pain and control conditions. Likewise, temporal summation of pressure pain on the knee, thigh and lower leg muscles was assessed.ResultsExperimental knee pain decreased the PPTs at the knee (P <0.01) and facilitated the temporal summation on the knee and adjacent muscles (P < 0.05). No significant difference was found at the control site (the contralateral arm) (P =0.77). Further, the experimental knee pain revealed overall higher VAS scores (facilitated temporal summation of pain) at the knee (P < 0.003) and adjacent muscles (P < 0.0001) compared with the control condition. The experimental knee pain areas were larger compared with the OA knee pain areas before the injection.ConclusionsAcute experimental knee pain induced in patients with knee OA caused hyperalgesia and facilitated temporal summation of pain at the knee and surrounding muscles, illustrating that the pain system in individuals with knee OA can be affected even after many years of nociceptive input. This study indicates that the adaptability in the pain system is intact in patients with knee OA, which opens for opportunities to prevent development of centralized pain syndromes.
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6

Ahn, Hyochol, Chengxue Zhong, Setor Sorkpor, and Hongyu Miao. "HOME-BASED TRANSCRANIAL DIRECT-CURRENT STIMULATION AND EXPERIMENTAL PAIN SENSITIVITY." Innovation in Aging 3, Supplement_1 (November 2019): S338. http://dx.doi.org/10.1093/geroni/igz038.1227.

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Abstract Osteoarthritis (OA) of the knee is one of the most common causes of pain in older adults. Clinic-based transcranial direct current stimulation (tDCS) is a noninvasive brain stimulation technique that has been shown to reduce pain, but no published studies have reported using home-based self-administered tDCS in older adults with knee OA. Thus, the purpose of this study was to examine the effect of home-based tDCS on experimental pain sensitivity in older adults with knee OA. Twenty community-dwelling participants aged 50–85 years with knee OA pain received ten daily sessions of 2 mA tDCS for 20 minutes at home. A multimodal quantitative sensory testing battery was completed, including heat pain tolerance, pressure pain threshold, and punctate mechanical pain. Participants (75% female) had a mean age of 61 years, and a mean body mass index in the sample was 28.33 kg/m2. All 20 participants completed all ten home-based tDCS sessions without serious adverse effects. The Wilcoxon Signed-Rank test showed that all the differences between the baseline measurements and experimental pain sensitivity measurements after 10 sessions were statistically significant. Effect sizes (Rosenthal’s R) were R = 0.35 for heat pain tolerance (P = 0.02), R = 0.40 for pressure pain threshold (P &lt; 0.01), and R = 0.32 for punctate mechanical pain (P = 0.02). We demonstrated that home-based self-administered tDCS was feasible and reduced experimental pain sensitivity in older adults with knee OA. Future studies with well-designed randomized controlled trials are needed to validate our findings.
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7

Park, Jihong, W. Matt Denning, Jordan D. Pitt, Devin Francom, J. Ty Hopkins, and Matthew K. Seeley. "Effects of Experimental Anterior Knee Pain on Muscle Activation During Landing and Jumping Performed at Various Intensities." Journal of Sport Rehabilitation 26, no. 1 (January 2017): 78–93. http://dx.doi.org/10.1123/jsr.2015-0119.

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Context:Although knee pain is common, some facets of this pain are unclear. The independent effects (ie, independent from other knee injury or pathology) of knee pain on neural activation of lower-extremity muscles during landing and jumping have not been observed.Objective:To investigate the independent effects of knee pain on lower-extremity muscle (gastrocnemius, vastus medialis, medial hamstrings, gluteus medius, and gluteus maximus) activation amplitude during landing and jumping, performed at 2 different intensities.Design:Laboratory-based, pretest, posttest, repeated-measures design, where all subjects performed both data-collection sessions.Methods:Thirteen able-bodied subjects performed 2 different land and jump tasks (forward and lateral) under 2 different conditions (control and pain), at 2 different intensities (high and low). For the pain condition, experimental knee pain was induced via a hypertonic saline injection into the right infrapatellar fat pad. Functional linear models were used to evaluate the influence of experimental knee pain on muscle-activation amplitude throughout the 2 land and jump tasks.Results:Experimental knee pain independently altered activation for all of the observed muscles during various parts of the 2 different land and jump tasks. These activation alterations were not consistently influenced by task intensity.Conclusion:Experimental knee pain alters activation amplitude of various lower-extremity muscles during landing and jumping. The nature of the alteration varies between muscles, intensities, and phases of the movement (ie, landing and jumping). Generally, experimental knee pain inhibits the gastrocnemius, medial hamstring, and gluteus medius during landing while independently increasing activation of the same muscles during jumping.
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8

Zhong, Guangjun, Zhu Liang, Jiang Kan, and Aikeremujiang Muheremu. "Selective peripheral nerve resection for treatment of persistent pain around the knee joint after total knee arthroplasty." Journal of International Medical Research 46, no. 6 (April 18, 2018): 2301–6. http://dx.doi.org/10.1177/0300060518764184.

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Objective This study was performed to determine the efficacy of selective peripheral nerve resection for treatment of persistent neuropathic pain after total knee arthroplasty (TKA). Methods Patients who underwent TKA in our department from January 2013 to July 2016 and experienced persistent pain around the knee joint after TKA were retrospectively included in the current study. Sixty patients were divided into experimental and control groups according the treatment they received. The treatment effect was evaluated by the Hospital for Special Surgery (HSS) knee score and visual analog scale (VAS) pain score preoperatively and at 1, 2, 3, 6, and 12 months postoperatively. Results The HSS knee scores were higher in both groups after than before the treatment, and HSS knee scores were significantly higher in the experimental group than in the control group. The VAS pain scores were lower in both groups after than before the treatment, and VAS pain scores were significantly lower in the experimental group than in the control group. Conclusions Selective peripheral nerve resection is an effective treatment method for persistent neuropathic pain after TKA.
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9

Perez-Huerta, Betsy Denisse, Belén Díaz-Pulido, Daniel Pecos-Martin, David Beckwee, Enrique Lluch-Girbes, Ruben Fernandez-Matias, María José Bolaños Rubio, and Tomas Gallego-Izquierdo. "Effectiveness of a Program Combining Strengthening, Stretching, and Aerobic Training Exercises in a Standing versus a Sitting Position in Overweight Subjects with Knee Osteoarthritis: A Randomized Controlled Trial." Journal of Clinical Medicine 9, no. 12 (December 20, 2020): 4113. http://dx.doi.org/10.3390/jcm9124113.

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There is an increasing incidence, prevalence, and burden of knee osteoarthritis due to a global increase in obesity and an aging population. The aim of the present study was to compare the effectiveness of the addition of aerobic exercises performed in an unloaded or loaded position to a conventional exercise program in overweight subjects with knee osteoarthritis. Twenty-four subjects were randomly allocated to receive 36 sessions of 30-min duration of either sitting aerobic exercises (experimental group) or standing aerobic exercises (control group). Pain intensity, knee disability, and quality-of-life data were collected at baseline and at 12, 24, and 36 sessions. Generalized linear mixed models (GLMMs) were constructed for the analysis of the differences. Significant differences were found in the experimental group for self-reported pain and knee pain and disability at 24 and 36 sessions (p < 0.05). Significant between-group differences were observed in change in self-reported knee pain and disability and quality of life from baseline to 24th- and 36th-session measurements in favor of the experimental group. Adherence to treatment was higher in the experimental group. Adding aerobic exercises in an unloaded position to a conventional exercise program produced superior effects over time for self-reported knee pain, knee pain and disability and quality of life compared to loaded aerobic exercises in overweight subjects with knee osteoarthritis.
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10

Palmieri-Smith, Riann M., Mark Villwock, Brian Downie, Garin Hecht, and Ron Zernicke. "Pain and Effusion and Quadriceps Activation and Strength." Journal of Athletic Training 48, no. 2 (March 1, 2013): 186–91. http://dx.doi.org/10.4085/1062-6050-48.2.10.

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Context: Quadriceps dysfunction is a common consequence of knee joint injury and disease, yet its causes remain elusive. Objective: To determine the effects of pain on quadriceps strength and activation and to learn if simultaneous pain and knee joint effusion affect the magnitude of quadriceps dysfunction. Design: Crossover study. Setting: University research laboratory. Patients or Other Participants: Fourteen (8 men, 6 women; age = 23.6 ± 4.8 years, height = 170.3 ± 9.16 cm, mass = 72.9 ± 11.84 kg) healthy volunteers. Intervention(s): All participants were tested under 4 randomized conditions: normal knee, effused knee, painful knee, and effused and painful knee. Main Outcome Measure(s): Quadriceps strength (Nm/kg) and activation (central activation ratio) were assessed after each condition was induced. Results: Quadriceps strength and activation were highest under the normal knee condition and differed from the 3 experimental knee conditions (P &lt; .05). No differences were noted among the 3 experimental knee conditions for either variable (P &gt; .05). Conclusions: Both pain and effusion led to quadriceps dysfunction, but the interaction of the 2 stimuli did not increase the magnitude of the strength or activation deficits. Therefore, pain and effusion can be considered equally potent in eliciting quadriceps inhibition. Given that pain and effusion accompany numerous knee conditions, the prevalence of quadriceps dysfunction is likely high.
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11

Joergensen, Tanja Schjoedt, Marius Henriksen, Bente Danneskiold-Samsoee, Henning Bliddal, and Thomas Graven-Nielsen. "Experimental Knee Pain Evoke Spreading Hyperalgesia and Facilitated Temporal Summation of Pain." Pain Medicine 14, no. 6 (April 16, 2013): 874–83. http://dx.doi.org/10.1111/pme.12093.

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12

Henriksen, Marius, Thomas Graven-Nielsen, Jens Aaboe, Thomas P. Andriacchi, and Henning Bliddal. "Gait changes in patients with knee osteoarthritis are replicated by experimental knee pain." Arthritis Care & Research 62, no. 4 (April 2010): 501–9. http://dx.doi.org/10.1002/acr.20033.

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13

Thenmozhi P, Nisha P, Prema J, and Shreeba R. "Effectiveness of contrast hydrotherapy on knee pain among osteoarthritis patients." International Journal of Research in Pharmaceutical Sciences 10, no. 4 (October 16, 2019): 3217–22. http://dx.doi.org/10.26452/ijrps.v10i4.1625.

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Many patients with osteoarthritis experiences knee pain, but if untreated, it may lead to chronic knee pain. This may quietly limit the functional abilities and impairs the quality of life. Thus the study was conducted with the aim to determine the effect of contrast hydrotherapy on knee pain. Quasi-experimental research design was adopted with 30 samples who met the inclusion criteria. Samples were assigned into experimental and control group by convenience sampling technique. A pre-test was conducted by using Numerical pain rating scale in both experimental and control group. Contrast hydrotherapy was administered to the experimental group, and the control group was continued with the routine practice. Post-test was conducted after 7 days with the same tool for both the group. Data were analyzed using SPSS. The study findings revealed that contrast hydrotherapy was effective in reducing the level of knee pain at the level of p<0.05 in the experimental group. Contrast hydrotherapy is inexpensive, safer method, does not cost the time, reduce the risk pharmacological intervention and can be affordable by all the participants. This therapy may be recommended in both clinical and community setting to reduce the pain, thereby improves the quality of life.
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Indriulionis, Tomas, Juozas Raistenskis, Kęstutis Saniukas, Rūta Garšvienė, Viktorija Zacharenko, Viktoras Vaičikauskas, Sigitas Kamandulis, et al. "EFFICIENCY OF ORTHOPAEDIC BRACE WITH LASER ON KNEE JOINT FUNCTION, PAIN AND SWELLING." Baltic Journal of Sport and Health Sciences 3, no. 98 (2015): 13–21. http://dx.doi.org/10.33607/bjshs.v3i98.89.

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Background. The effectiveness of outpatient mobile laser intervention on specific treatment goals has not been fully explored. Thus, the aim of the study was to examine the effect of orthopaedic knee brace with laser on knee joint function, pain and swelling. Methods. Volunteers were divided into two experimental groups: chronic pain (n = 20, knee pain > 6 months) and acute pain (n = 20, knee pain < 1 week), and one control (n = 20, placebo) group. Subjects in all groups were immobilized in a knee brace for 4 weeks. In addition, the experimental groups underwent low-intensity laser therapy, whereas control group underwent pseudo-laser therapy, every second day for 10 min. The sequences of the tests were as follows: (a) clinical assessments and evaluation of knee extension and flexion amplitude, swelling, Lysholm subjective assessment questionnaire, VAS pain scale, (b) evaluation of balance using Kistler platform, (c) muscle peak torque and isometric torque variability assessment using isokinetic dynamometry. All tests were performed twice - before and after intervention. Results. Knee brace with laser is effective treatment for the reduction of pain, swelling, and recovering of daily functions (p < .05). Operation of the complex device is particularly effective in treating knee pain in the acute period (p < .05). Conclusions. Knee brace with laser therapy in the rehabilitation period ensures faster healing of patients compared to wearing only knee brace, particularly in acute pain, while muscle strength and proprioception remains depressed.
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15

Ahn, Hyochol, Jun-Ho La, Jin M. Chung, Hongyu Miao, Chengxue Zhong, Miyong Kim, Kyungeh An, Debra Lyon, Eunyoung Choi, and Roger B. Fillingim. "The Relationship Between β-Endorphin and Experimental Pain Sensitivity in Older Adults With Knee Osteoarthritis." Biological Research For Nursing 21, no. 4 (May 30, 2019): 400–406. http://dx.doi.org/10.1177/1099800419853633.

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Osteoarthritis (OA) is the most common cause of pain in people aged >45 years, and the knee is the most commonly affected joint. There is a growing interest in understanding the biological factors that influence pain among older adults, but few studies have examined the relationship between β-endorphin and experimental pain sensitivity in older adults with knee OA pain. The purpose of this study was to investigate the relationship between resting plasma levels of β-endorphin and experimental pain sensitivity. This study was a secondary analysis of data for 40 adults with knee OA pain in whom quantitative sensory testing was used to measure experimental sensitivity to heat- and mechanically induced pain. The mean age of the sample was 60 years ( SD = 9 years), and approximately half were female (53%). Regression analyses indicated that β-endorphin level was negatively related to pressure pain threshold (β = −17.18, p = .02) and positively related to punctate mechanical pain (β = 17.13, p = .04), after controlling for age, gender, and OA severity. We did not find a significant relationship between β-endorphin and heat pain tolerance. The results suggest that higher circulating levels of β-endorphin at rest are associated with increased sensitivity to mechanical pain in older adults with knee OA. These findings add to the literature regarding biological factors associated with pain sensitivity in older adults with chronic pain. Additional studies are needed to identify mediators of the relationship between β-endorphin and pain sensitivity in OA and other musculoskeletal pain conditions.
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Holm, Bente, Henrik Husted, Henrik Kehlet, and Thomas Bandholm. "Effect of knee joint icing on knee extension strength and knee pain early after total knee arthroplasty: a randomized cross-over study." Clinical Rehabilitation 26, no. 8 (January 19, 2012): 716–23. http://dx.doi.org/10.1177/0269215511432017.

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Objective: To investigate the acute effect of knee joint icing on knee extension strength and knee pain in patients shortly after total knee arthroplasty. Design: A prospective, single-blinded, randomized, cross-over study. Setting: A fast-track orthopaedic arthroplasty unit at a university hospital. Participants: Twenty patients (mean age 66 years; 10 women) scheduled for primary unilateral total knee arthroplasty. Interventions: The patients were treated on two days (day 7 and day 10) postoperatively. On one day they received 30 minutes of knee icing (active treatment) and on the other day they received 30 minutes of elbow icing (control treatment). The order of treatments was randomized. Main outcome measures: Maximal knee extension strength (primary outcome), knee pain at rest and knee pain during the maximal knee extensions were measured 2–5 minutes before and 2–5 minutes after both treatments by an assessor blinded for active or control treatment. Results: The change in knee extension strength associated with knee icing was not significantly different from that of elbow icing (knee icing change (mean (1 SD)) –0.01 (0.07) Nm/kg, elbow icing change –0.02 (0.07) Nm/kg, P = 0.493). Likewise, the changes in knee pain at rest ( P = 0.475), or knee pain during the knee extension strength measurements ( P = 0.422) were not different between treatments. Conclusions: In contrast to observations in experimental knee effusion models and inflamed knee joints, knee joint icing for 30 minutes shortly after total knee arthroplasty had no acute effect on knee extension strength or knee pain.
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17

Henriksen, M., T. Graven-Nielsen, J. Aaboe, T. P. Andriacchi, and H. Bliddal. "139 GAIT CHANGES IN PATIENTS WITH KNEE OSTEOARTHRITIS ARE REPLICATED BY EXPERIMENTAL KNEE PAIN." Osteoarthritis and Cartilage 17 (September 2009): S83—S84. http://dx.doi.org/10.1016/s1063-4584(09)60161-8.

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18

Schache, A., K. Crossley, and M. Pandy. "Immediate effects of acute experimental anterior knee pain on knee joint biomechanics during gait." Journal of Science and Medicine in Sport 12 (January 2009): S66—S67. http://dx.doi.org/10.1016/j.jsams.2008.12.158.

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Zuhri, Saifudin. "Pengaruh Phonophoresis Untuk Menurunkan Nyeri Pasien Osteoarthritis Lutut." Jurnal Keterapian Fisik 4, no. 2 (November 28, 2019): 85–91. http://dx.doi.org/10.37341/jkf.v4i2.191.

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Background: In everyday life activities human beings need prime conditions to create functional motion. One factor that interferes with functional motion is pain. The goal of physiotherapy for people with pain is to relieve pain. Many of the physiotherapy modalities recommended for reducing pain include phonophoresis. But the phonophoresis modality has not been widely implemented in Indonesia. Objective: To determine the effect of phonophoresis on reducing knee pain in patients with knee osteoarthritis. Methods: This study was a pure experiment with a pre-test and post-test with control group design. The study subjects were patients with knee osteoarthritis who met the inclusion and exclusion criteria. From the number of patients who came to the physiotherapy polyclinic of Dr Moewardi Hospital Surakarta, they would be randomized to the experimental group and the control group. The experimental group will get standard therapy at Dr Moewardi Hospital Surakarta plus phonophoresis, while the control group only gets standard therapy from the hospital. The independent variable is the administration of phonophoresis and the dependent variable is a decrease in knee pain. Statistical analysis using t-test. Results: Of Phonophoresis and standard therapy can reduce knee pain. More pain occurs in phonophoresis. Conclusion: Phonophoresis can be selected as a therapy to reduce pain in people with osteoarthritis
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Cardoso, J., R. Bush, R. Pop, E. Weber, Y. Cruz-Almeida, J. Riley, T. Glover, et al. "(200) Experimental pain phenotyping in older adults with knee osteoarthritis." Journal of Pain 16, no. 4 (April 2015): S26. http://dx.doi.org/10.1016/j.jpain.2015.01.115.

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Suda, Eneida Yuri, Rogerio Pessoto Hirata, Thorvaldur Palsson, Nicolas Vuillerme, Isabel C. N. Sacco, and Thomas Graven-Nielsen. "Experimental knee-related pain enhances attentional interference on postural control." European Journal of Applied Physiology 119, no. 9 (July 20, 2019): 2053–64. http://dx.doi.org/10.1007/s00421-019-04192-9.

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22

Salomoni, Sauro E., Ashir Ejaz, Anders C. Laursen, and Thomas Graven-Nielsen. "Variability of three-dimensional forces increase during experimental knee pain." European Journal of Applied Physiology 113, no. 3 (July 28, 2012): 567–75. http://dx.doi.org/10.1007/s00421-012-2461-2.

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23

Asaki, T., Kelun Wang, Y. Luo, T. Arendt-Nielsen, T. Graven-Nielsen, and L. Arendt-Nielsen. "Acid-induced experimental knee pain and hyperalgesia in healthy humans." Experimental Brain Research 236, no. 2 (December 18, 2017): 587–98. http://dx.doi.org/10.1007/s00221-017-5155-5.

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24

Cardoso, Josue S., Joseph L. Riley, Toni Glover, Kimberly T. Sibille, Emily J. Bartley, Burel R. Goodin, Hailey W. Bulls, et al. "Experimental pain phenotyping in community-dwelling individuals with knee osteoarthritis." PAIN 157, no. 9 (September 2016): 2104–14. http://dx.doi.org/10.1097/j.pain.0000000000000625.

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Myrer, J. William, J. Brent Feland, and Gilbert W. Fellingham. "The Effects of a Topical Analgesic and Placebo in Treatment of Chronic Knee Pain." Journal of Aging and Physical Activity 12, no. 2 (April 2004): 199–213. http://dx.doi.org/10.1123/japa.12.2.199.

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Chronic knee pain is a prevalent health problem of old and middle age. The authors’ objective was to determine whether a topical analgesic would reduce knee pain and improve the function of a group of 40- to 65-year-old people with chronic knee pain. The experimental design was a double-blind, randomized, placebo-controlled clinical trial. The dependent variables were knee pain, active range of motion, and isometric strength. Forty-six men and women volunteered, of whom 3 dropped out, leaving 23 in the treatment group and 20 in the placebo group. Knee pain was assessed with a visual analogue scale and the knee-pain scale for frequency and severity. Testing took place before treatment and after 21 and 35 days of treatment. The results indicated that although both groups experienced improved pain scores, there were no differences between groups over the treatment period for any of the dependent variables.
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Tosun, Betul, Nursemin Unal, Deniz Yigit, Nuray Can, Ozlem Aslan, and Servet Tunay. "Effects of Self-Knee Massage With Ginger Oil in Patients With Osteoarthritis: An Experimental Study." Research and Theory for Nursing Practice 31, no. 4 (2017): 379–92. http://dx.doi.org/10.1891/1541-6577.31.4.379.

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Background and Purpose:The purpose of our study was to assess the effects of self-knee massage with ginger oil on pain and daily living activities in patients with knee osteoarthritis.Methods:Participants (N= 68) were asked about their sociodemographic characteristics, pain level in the last week using the Visual Analog Scale (VAS), and functionality in activities of daily living with the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Standard treatment prescribed by a physician was given to the patients with osteoarthritis. In addition to the standard treatment, self-knee massage with ginger oil twice a week was recommended to the intervention group (n= 34). At the end of the first and fifth week, participants in both groups were assessed regarding pain and functional state.Results:The mean VAS Pain scores of the intervention group were significantly lower at the end of the first and fifth weeks (p< .05). The mean total scores and mean Function subscale scores of the WOMAC were significantly lower in massage group in the first- and fifth-week assessments (p< .05).Implications for Practice:Self-massage of the knee with ginger oil may be used as a complementary method to standard medical treatment. Nurses can easily train patients and their caregivers on knee massage, and the intervention can be implemented by patients at home without any restrictions on location.
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Das, Shyam, and Kavitha Chandran C. "Effect of multimodal interventions on pain and activities of daily living among the elderly with osteoarthritis." Journal of Applied and Advanced Research 1, no. 3 (October 21, 2016): 53. http://dx.doi.org/10.21839/jaar.2016.v1i3.34.

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The aim of the present study was to assess the effect of multimodal interventions on pain and activities of daily living among the elderly with knee osteoarthritis attending Physical Medicine and Rehabilitation OPD at General Hospital Alappuzha,Kerala. Objectives were to assess the level of joint pain in elderly with knee osteoarthritis, to assess the ability of elderly to perform activities of daily living, to evaluate the effect of multimodal interventions on pain and activities of daily living of elderly with knee osteoarthritis and to find out association between multimodal interventions and analgesic usage. The investigator adopted quantitative experimental approach for the study and research design was quasi experimental non equivalent control group design. The sample size was 74 elderly patients diagnosed as knee osteoarthritis selected using purposive sampling technique. A structured interview schedule was used to assess the socio personal and clinical data; pain and activities of daily living were assessed by numerical pain rating scale and Katz index respectively. Routine care was given to control group, while the experimental group underwent multimodal interventions which included educational session, isometric exercises and moist heat application for three weeks along with routine care. After three weeks, post-test was done in both groups. The findings revealed that there was a significant reduction in pain (P<0.001), improvement in activities of daily living (P<0.001) and also reduction in frequency of analgesic intake (p< 0.001) among elderly with knee osteoarthritis.
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Simamora, Marthalena, Galvani Volta Simanjuntak, and Henny Syapitri. "KNEE FLEXION EXTENSION AND STRENGTHENING (FELS) EXERCISE TO PAIN INTENSITY IN KNEE OSTEOARTHRITIS PATIENTS." INDONESIAN NURSING JOURNAL OF EDUCATION AND CLINIC (INJEC) 2, no. 2 (March 2, 2018): 274. http://dx.doi.org/10.24990/injec.v2i2.43.

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Introduction. Osteoarthritis (OA) is a degenerative disease due to the thinning of the joint cartilage, mostly in the knee joint (89.91%) with the pain manifestation. If the pain is not managed, it could lead to the limitation of movement and disruption of daily activities. Having physical exercise regularly could reduce pain. The purpose of study was to determine the effect of knee fl exion extension and strengthening (FELS) exercise in reducing pain intensity. Methods. This was a quasi-experimental study with pretest-posttest control randomized design, where 70 respondents were recruited and consisted of 53 in intervention and 17 in control group. Result. The statistical analysis used ordinal regression revealed (1) FELS exercise was effective in reducing pain intensity (p = 0.013); (2) a signifi cant difference in pain intensity before and after FELS exercise (p = 0.000); (3) a signifi cant difference of pain intensity in the intervention group compared to the control group (p = 0.004); (4) effect of other activities in reducing pain intensity (p = 0.042). While the factors of age, gender, pain experience, anxiety and support system were not signifi cantly effective in reducing pain. Discussion. FELS exercise was helpful in reducing pain intensity in patients with knee osteoarthritis. It was then suggested to OA patients are requested to perform regular FELS exercise while the families are keep on giving support to the patient to do FELS exercise.Keywords: Knee fl exion extension, strengthening exercise, pain intensity, knee OA
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Kumar, Sunny, M. Usman Khan, and Qurat ul Ain Adnan. "EFFECTIVENESS OF MANUAL TRACTION IN COMPARISON TO ELECTROTHERAPY (TRANSCUTANEOUS ELECTRICAL NERVE STIMULATION - TENS) IN THE TREATMENT OF KNEE OSTEOARTHRITIS." Pakistan Journal of Rehabilitation 3, no. 2 (July 5, 2014): 26–30. http://dx.doi.org/10.36283/pjr.zu.3.2/006.

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OBJECTIVE To determine the effects of manual traction in knee arthritis patients in comparison to electrotherapy (TENS). STUDY DESIGN Randomized Control Trial (Experimental Study). STUDY SETTINGS & PARTICIPANTS Study was conducted in a Tertiary Care Hospital with a sample of 310 participants. INTERVENTIONS Manual traction and Electrotherapy Transcutaneous electrical nerve stimulation (TENS) will be used to manage pain in patients with Knee Osteoarthritis. OUTCOME MEASURES Oxford Knee Pain Scale was used to measure pain and functional activities. RESULTS Improvements were seen in both groups but results of manual traction were more significant. There were major differences present in knee pain intensity before and after treatment. The group that received manual traction reported a decrease in the severity of pain of mean 15.01 which is comparatively better than the group that received electro therapy and reported a decrease in severity of pain of mean 12.42. CONCLUSION The result of this research supports the application of manual TF joint traction as a mean of stretching shortened articular and periarticular tissues with decreased in levels of pain either during the treatment or at the end of session. There is significant improvement in knee flexion AROM. Pain level decreases during every treatment session. KEY WORDS Knee Pain, Traction, Mobilization, Tibio-Femoral Joint, TENS, Knee OA.
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Sülük, Ünal, Mutlu Çobanoğlu, and İlhan Özkan. "Developmental patello-femoral displasia (experimental study)." Orthopaedic Journal of Sports Medicine 5, no. 2_suppl2 (February 1, 2017): 2325967117S0009. http://dx.doi.org/10.1177/2325967117s00099.

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Similar to developmental hip dysplasia patella is an important factor for the development of femoral troclea. This study was performed in an attempt to evaluate the effect of patella on development of femoral trochlea. Thirty two 4 weeks old New Zeeland rabbits were used in this study. Patella of the left knee was dislocated and 4 weeks after, a new operation was performed to relocate the patella to its normal anatomical location (group 1, 16 rabbits). In the second 16 rabbits patella of the left knee was dislocated and no other surgical intervention was performed (group 2). All the non operated right knees were used as the control group (group 3). All the rabbits were sacrificed when they were 6 months old. Computed tomography (CT) was performed to measure femoral sulcus angle and femoral trochlear dept in every knee. Kolmogorov-Smirnov, Anova and Kruskal-Wallis tests were used to evaluate the results. Trochlear sulcus angle was measured as 127.7 degree in group 1, 133.85 degree in group 2 and 127.0 degree in control group. The depth of the trochlear grove is 1.41 mm, 1.15 mm and 1.26 mm respectively. Trochlear sulcus angle and depth that were measured in group 2 were statistically different from group 1 and control group (P<0.05). The most important finding of this study is insufficient development of trochlear sulcus in group 1 in which the patella was dislocated. Bone development is a complex procedure, mechanical stress has an important role on bone morphology. This study showed that patellar impulse is needed for a normal trochlear sulcus development. Similar to developmental hip dysplasia shallow trochlear sulcus due to insufficient patellar impulse can be named as “developmental patello-femoral dysplasia”. Malposition of patella on trochlear grove has an important role in patello-femoral pain syndrolme. Diagnosis and treatment of this malposition in early ages can reduce the incidence of patello-femoral pain syndrome and other patello-femoral abnormalities in adult age. This study demonstrated that, similar to developmental hip dysplasia, patello-femoral dysplasia must be diagnosed and treated in early ages to prevent anatomical abnormalities. [Figure: see text]
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Rice, David A., Gwyn N. Lewis, Thomas Graven-Nielsen, Rufus Luther, and Peter J. McNair. "Experimental Hand and Knee Pain Cause Differential Effects on Corticomotor Excitability." Journal of Pain 22, no. 7 (July 2021): 789–96. http://dx.doi.org/10.1016/j.jpain.2021.01.006.

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Hug, François, Paul W. Hodges, Wolbert van den Hoorn, and Kylie Tucker. "Between-muscle differences in the adaptation to experimental pain." Journal of Applied Physiology 117, no. 10 (November 15, 2014): 1132–40. http://dx.doi.org/10.1152/japplphysiol.00561.2014.

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This study aimed to determine whether muscle stress (force per unit area) can be redistributed between individual heads of the quadriceps muscle when pain is induced into one of these heads. Elastography was used to measure muscle shear elastic modulus (an index of muscle stress). Electromyography (EMG) was recorded from vastus lateralis (VL), vastus medialis (VM), and rectus femoris (RF). In experiment I ( n = 20), participants matched a knee extension force, and thus any reduction of stress within the painful muscle would require compensation by other muscles. In experiment II ( n = 13), participants matched VL EMG amplitude and were free to vary external force such that intermuscle compensation would be unnecessary to maintain the experimental task. In experiments I and II, pain was induced by injection of hypertonic saline into VM or RF. Experiment III aimed to establish whether voluntary drive to the individual muscles could be controlled independently. Participants ( n = 13) were asked to voluntarily reduce activation of VM or RF while maintaining knee extension force. During VM pain, there was no change in shear elastic modulus ( experiments I and II) or EMG amplitude of VM ( experiment II). In contrast, RF pain was associated with a reduction in RF elastic modulus ( experiments I and II: −8 to −17%) and EMG amplitude ( experiment II). Participants could voluntarily reduce EMG amplitude of RF ( −26%; P = 0.003 ) but not VM ( experiment III). These results highlight between-muscle differences in adaptation to pain that might be explained by their function (monoarticular vs. biarticular) and/or the neurophysiological constraints associated to their activation.
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Stanton, Tasha R., Helen R. Gilpin, Louisa Edwards, G. Lorimer Moseley, and Roger Newport. "Illusory resizing of the painful knee is analgesic in symptomatic knee osteoarthritis." PeerJ 6 (July 17, 2018): e5206. http://dx.doi.org/10.7717/peerj.5206.

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Background Experimental and clinical evidence support a link between body representations and pain. This proof-of-concept study in people with painful knee osteoarthritis (OA) aimed to determine if: (i) visuotactile illusions that manipulate perceived knee size are analgesic; (ii) cumulative analgesic effects occur with sustained or repeated illusions. Methods Participants with knee OA underwent eight conditions (order randomised): stretch and shrink visuotactile (congruent) illusions and corresponding visual, tactile and incongruent control conditions. Knee pain intensity (0–100 numerical rating scale; 0 = no pain at all and 100 = worst pain imaginable) was assessed pre- and post-condition. Condition (visuotactile illusion vs control) × Time (pre-/post-condition) repeated measure ANOVAs evaluated the effect on pain. In each participant, the most beneficial illusion was sustained for 3 min and was repeated 10 times (each during two sessions); paired t-tests compared pain at time 0 and 180s (sustained) and between illusion 1 and illusion 10 (repeated). Results Visuotactile illusions decreased pain by an average of 7.8 points (95% CI [2.0–13.5]) which corresponds to a 25% reduction in pain, but the tactile only and visual only control conditions did not (Condition × Time interaction: p = 0.028). Visuotactile illusions did not differ from incongruent control conditions where the same visual manipulation occurred, but did differ when only the same tactile input was applied. Sustained illusions prolonged analgesia, but did not increase it. Repeated illusions increased the analgesic effect with an average pain decrease of 20 points (95% CI [6.9–33.1])–corresponding to a 40% pain reduction. Discussion Visuotactile illusions are analgesic in people with knee OA. Our results suggest that visual input plays a critical role in pain relief, but that analgesia requires multisensory input. That visual and tactile input is needed for analgesia, supports multisensory modulation processes as a possible explanatory mechanism. Further research exploring the neural underpinnings of these visuotactile illusions is needed. For potential clinical applications, future research using a greater dosage in larger samples is warranted.
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Ahn, Hyochol, Setor K. Sorkpor, Miyong Kim, Hongyu Miao, Chengxue Zhong, Jing Wang, Debra Lyon, and Roger B. Fillingim. "The Relationship between Acculturation and Experimental Pain Sensitivity in Asian Americans with Knee Osteoarthritis." Pain Research and Management 2018 (November 29, 2018): 1–6. http://dx.doi.org/10.1155/2018/9128015.

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Multiple studies in healthy populations and clinical samples have shown that ethnic minorities have greater pain sensitivity than their majority counterparts. Acculturation is speculated to be one of the sociocultural factors contributing to pain sensitivity since cultural beliefs and practices can influence the way patients perceive and respond to pain. However, the relationship of acculturation to pain sensitivity in minority populations remains poorly understood. Therefore, in this cross-sectional study, we examined the relationship between acculturation and experimental pain sensitivity in 50 Asian Americans residing in North Central Florida with knee osteoarthritis pain. The Suinn-Lew Asian Self Identity Acculturation Scale was used to assess acculturation, and multimodal quantitative sensory testing was performed to measure experimental sensitivity, including heat pain tolerance, pressure pain threshold, and punctate mechanical pain. Descriptive and regression analyses were performed. Participants’ mean age was 55.7 years, and about half of this sample were Korean American (56%). The participants had lived in the United States for 21 years on average. Regression analyses indicated that lower acculturation to American culture may contribute to greater experimental pain sensitivity. Asian Americans who were more acculturated to the American culture had higher heat pain tolerance (beta = 0.61, P=0.01), higher pressure pain threshold (beta = 0.59, P=0.02), and lower ratings of punctate mechanical pain (beta = −0.70, P<0.01). These findings add to the literature regarding sociocultural factors associated with pain in Asian Americans; additional research with a larger and more diverse sample of Asian Americans is warranted for cross-validation.
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Habuchi, Hiroko, Masashi Izumi, Junpei Dan, Takahiro Ushida, Masahiko Ikeuchi, Kosei Takeuchi, and Osami Habuchi. "Bone marrow derived mast cells injected into the osteoarthritic knee joints of mice induced by sodium monoiodoacetate enhanced spontaneous pain through activation of PAR2 and action of extracellular ATP." PLOS ONE 16, no. 6 (June 4, 2021): e0252590. http://dx.doi.org/10.1371/journal.pone.0252590.

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Conditions that resemble osteoarthritis (OA) were produced by injection of sodium monoiodoacetate (MIA) into the knee joints of mice. Bone marrow derived mast cells (BMMCs) injected into the OA knee joints enhanced spontaneous pain. Since no spontaneous pain was observed when BMMCs were injected into the knee joints of control mice that had not been treated with MIA, BMMCs should be activated within the OA knee joints and release some pain-inducible factors. Protease activated receptor-2 (PAR2) antagonist (FSLLRY-NH2) almost abolished the pain-enhancing effects of BMMCs injected into the OA knee joints, suggesting that tryptase, a mast cell protease that is capable of activating PAR2, should be released from the injected BMMCs and enhance pain through activation of PAR2. When PAR2 agonist (SLIGKV-NH2) instead of BMMCs was injected into the OA knee joints, it was also enhanced pain. Apyrase, an ATP degrading enzyme, injected into the OA knee joints before BMMCs suppressed the pain enhanced by BMMCs. We showed that purinoceptors (P2X4 and P2X7) were expressed in BMMCs and that extracellular ATP stimulated the release of tryptase from BMMCs. These observations suggest that ATP may stimulate degranulation of BMMCs and thereby enhanced pain. BMMCs injected into the OA knee joints stimulated expression of IL-1β, IL-6, TNF-α, CCL2, and MMP9 genes in the infrapatellar fat pads, and PAR2 antagonist suppressed the stimulatory effects of BMMCs. Our study suggests that intermittent pain frequently observed in OA knee joints may be due, at least partly, to mast cells through activation of PAR2 and action of ATP, and that intraarticular injection of BMMCs into the OA knee joints may provide a useful experimental system for investigating molecular mechanisms by which pain is induced in OA knee joints.
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King, C. D., K. T. Sibille, B. R. Goodin, Y. Cruz-Almeida, T. L. Glover, E. Bartley, J. L. Riley, et al. "Experimental pain sensitivity differs as a function of clinical pain severity in symptomatic knee osteoarthritis." Osteoarthritis and Cartilage 21, no. 9 (September 2013): 1243–52. http://dx.doi.org/10.1016/j.joca.2013.05.015.

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Phillips, J., and MF Coetsee. "A censervative programme for treatment of anterior knee pain in adolescents." South African Journal of Sports Medicine 20, no. 1 (March 5, 2008): 14. http://dx.doi.org/10.17159/2078-516x/2008/v20i1a286.

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Objective. The purpose of this study was to determine the effectiveness of a 2½-week conservative rehabilitation programme in addressing anterior knee pain in adolescents. Design. Subjects were randomly allocated to a control group (N=12) and an experimental group (N=18). The experimental group was subjected to a 2½-week strength, flexibility and neuromuscular rehabilitation programme. Both groups were tested before and after the 2½ weeks and the experimental group also 1 month after the post-test. Results. The experimental group reported significant (p
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Phillips, J., and MF Coetsee. "A censervative programme for treatment of anterior knee pain in adolescents." South African Journal of Sports Medicine 20, no. 1 (February 5, 2009): 14. http://dx.doi.org/10.17159/2413-3108/2008/v20i1a286.

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Objective. The purpose of this study was to determine the effectiveness of a 2½-week conservative rehabilitation programme in addressing anterior knee pain in adolescents. Design. Subjects were randomly allocated to a control group (N=12) and an experimental group (N=18). The experimental group was subjected to a 2½-week strength, flexibility and neuromuscular rehabilitation programme. Both groups were tested before and after the 2½ weeks and the experimental group also 1 month after the post-test. Results. The experimental group reported significant (p
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Shetty, Kavitha, Lawrence Mathias, Mahesh V. Hegde, and Sukumar Shanmugam. "Short - Term Effects of Eccentric Hip Abductors and Lateral Rotators Strengthening In Sedentary People with Patellofemoral Pain Syndrome on Pain and Function : A Randomized Control Trail." Journal of Health and Allied Sciences NU 06, no. 01 (March 2016): 068–73. http://dx.doi.org/10.1055/s-0040-1708621.

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Abstract Purpose: To investigate the influence of additional eccentric strengthening to the hip abductor and lateral rotator musculature on pain and function in sedentary people with Patellofemoral pain syndrome (PFPS). Methods: 30 sedentary patients between 18 and 40 years of age, with a diagnosis of PFPS, all the subjects received treatment for a period of 4weeks and the subjects were randomly assigned to Control group (CG) and Experimental group (EG). The patients in the Control group (n = 15) performed a conventional knee-stretching and strengthening program, whereas, patients in the Experimental group (n = 15) performed the same exercises as those in the control group ,in addition received eccentric strengthening exercises for the hip abductors and lateral rotators. An 11-point numeric pain rating scale (NPRS), the Lower Extremity Functional Scale (LEFS) and the Anterior Knee Pain Scale (AKPS) were used as outcome measures during the baseline and at the end of 4weeks . Results: Statistics were retrieved using SPSS.16, paired 't' test was conducted to compare AKPS and LEFS values ,whereas, Mann- Whitney U test was used for NPRS value between the groups. After 4 weeks of treatment, the control group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance and even in the experimental group, pre and post-test value for AKPS (p<0.001),LEFS (P<0.001),NPRS (p<0.001) shows a statistical significance in pain and function, but comparing both the group experimental group is significantly more better AKPS (p=0.002),LEFS (P<0.001),NPRS (P<0.001) then a control group. Conclusion: short term Knee strengthening exercises supplemented by eccentric hip abductor and lateral rotator musculature–strengthening exercises were more effective than knee exercises alone in improving function and reducing pain in sedentary people with PFPS.
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Mølgaard, Carsten M., Thomas Graven-Nielsen, Ole Simonsen, and Uwe G. Kersting. "Potential interaction of experimental knee pain and laterally wedged insoles for knee off-loading during walking." Clinical Biomechanics 29, no. 8 (September 2014): 848–54. http://dx.doi.org/10.1016/j.clinbiomech.2014.08.002.

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Sangesland, Anders, Carl Støren, and Henrik B. Vaegter. "Are preoperative experimental pain assessments correlated with clinical pain outcomes after surgery? A systematic review." Scandinavian Journal of Pain 15, no. 1 (April 1, 2017): 44–52. http://dx.doi.org/10.1016/j.sjpain.2016.12.002.

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AbstractBackgroundPain after surgery is not uncommon with 30% of patients reporting moderate to severe postoperative pain. Early identification of patients prone to postoperative pain may be a step forward towards individualized pain medicine providing a basis for improved clinical management through treatment strategies targeting relevant pain mechanisms in each patient. Assessment of pain processing by quantitative sensory testing (QST) prior to surgery has been proposed as a method to identify patients at risk for postoperative pain, although results have been conflicting. Since the last systematic review, several studies investigating the association between postoperative pain and more dynamic measures of pain processing like temporal summation of pain and conditioned pain modulation have been conducted.ObjectivesAccording to the PRISMA guidelines, the aim of this systematic review was to evaluate whether assessment of experimental pain processing including measures of central pain mechanisms prior to surgery was associated with pain intensity after surgery.MethodsSystematic database searches in PubMed and EMBASE with the following search components: QST, association, and postoperative pain, for studies that assessed the association between QST and pain after surgery were performed. Two authors independently reviewed all titles and abstracts to assess their relevance for inclusion. Studies were included if (1) QST was performed prior to surgery, (2) pain was assessed after surgery, and (3) the association between QST and pain after surgery was investigated. Forty-four unique studies were identified, with 30 studies on 2738 subjects meeting inclusion criteria. The methodological quality of the include studies was assessed and data extraction included study population, type of surgery, QST variables, clinical pain outcome measure and main result.ResultsMost studies showed moderate to high risk of bias. Type of surgery investigated include 7 studies on total knee replacement, 5 studies on caesarean section, 4 studies on thoracic surgery, 2 studies on herniotomy, 2 studies on hysterectomy/myomectomy, 1 study on tubal ligation, 1 study on gynecologic laparoscopy, 1 study on arthroscopic knee surgery, 1 study on shoulder surgery, 1 study on disc herniation surgery, 1 study on cholecystectomy,1 study on percutaneous nephrolithotomy,1 study on molar surgery, 1 study on abdominal surgery, and 1 study on total knee replacement and total hip replacement. The majority of the preoperative QST variables showed no consistent association with pain intensity after surgery. Thermal heat pain above the pain threshold and temporal summation of pressure pain were the QST variables, which showed the most consistent association with acute or chronic pain after surgery.ConclusionsQST before surgery does not consistently predict pain after surgery. High quality studies investigating the presence of different QST variables in combination or along with other pain-related psychosocial factors are warranted to confirm the clinical relevance of QST prior to surgery.ImplicationsAlthough preoperative QST does not show consistent results, future studies in this area should include assessment of central pain mechanisms like temporal summation of pressure pain, conditioned pain modulation, and responses to pain above the pain threshold since these variables show promising associations to pain after surgery.
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Arazpour, Mokhtar, Monireh Ahmadi Bani, Maryam Maleki, Farhad Tabatabai Ghomshe, Reza Vahab Kashani, and Stephen W. Hutchins. "Comparison of the efficacy of laterally wedged insoles and bespoke unloader knee orthoses in treating medial compartment knee osteoarthritis." Prosthetics and Orthotics International 37, no. 1 (August 3, 2012): 50–57. http://dx.doi.org/10.1177/0309364612447094.

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Background: Patients suffering from medial compartment knee osteoarthritis (OA) may be treated with unloader knee orthoses or laterally wedged insoles. Objectives: The aim of this study was to identify and compare the effects of them on the gait parameters and pain in these patients. Study Design: Quasi-experimental. Methods: Volunteer subjects with medial compartment knee OA ( n = 24, mean age 59.29 ± 2.23 years) were randomly assigned to two separate groups and evaluated when wearing an unloader knee orthosis or insoles incorporating a 6° lateral wedge. Testing was performed at baseline and after six weeks of each orthosis use. A visual analog scale score was used to assess pain and gait analysis was utilized to determine gait parameters. Results: Both orthoses improved all parameters compared to the baseline condition ( p = 0.000). However, no significant differences in pain ( p = 0.649), adduction moment ( p = 0.205), speed of walking ( p = 0. 056) or step length ( p = 0.687) were demonstrated between them. The knee range of motion ( p = 0.000) were significantly different between the two interventions. Conclusion: Both orthoses reduced knee pain. Maximum knee range of motion was increased by both interventions although it was 3 degrees less when wearing the knee orthosis. Clinical relevance Both orthoses reduce pain and improve gait anomalies in medial compartment knee OA. Our results suggest a laterally wedged insole can be an alternative conservative approach to unloader knee orthosis for treating symptoms of medial compartment knee OA.
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Antonelli, Gabriela, Melissa Yuka Outi, Bruna Gomes Muller, Aline Cristiane Binda, João Afonso Ruaro, and Andersom Ricardo Fréz. "Técnica de energia muscular no tratamento da dor inespecífica de joelho associada à disfunção sacroilíaca." Manual Therapy, Posturology & Rehabilitation Journal 14 (December 31, 2016): 423. http://dx.doi.org/10.17784/mtprehabjournal.2016.14.423.

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Objective: to check the effectiveness of the increase on sacroiliac joint mobility on the painful knee among university students. Method: this was an experimental study with 13 students, from 18 to 25 years, which were subjected to an application of muscle energy technique in the sacroiliac joint. The knee functioning was assessed using the International Knee Documentation Committee Subjective Knee Form (IKDC). To classify the functioning was applied the International Classification of Functioning, Disability and Health generic core set. As for pain assessment, it was used the visual analog scale (VAS). Results: in initial evaluation, the referred pain was 6.1±1.3. After intervention was observed significant difference (p=0,0009), and reported pain of 3.3±2.7. Conclusion: a muscle energy technique applied in sacroiliac joint can be used for reduction of unspecific painful symptomatology of knee joint.
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Suchting, Robert, Shweta Kapoor, Kenneth B. Mathis, and Hyochol Ahn. "Changes in Experimental Pain Sensitivity from Using Home-Based Remotely Supervised Transcranial Direct Current Stimulation in Older Adults with Knee Osteoarthritis." Pain Medicine 21, no. 11 (August 31, 2020): 2676–83. http://dx.doi.org/10.1093/pm/pnaa268.

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Abstract Objective The present study examined the effects of home-based remotely supervised transcranial direct current stimulation on quantitative sensory testing measurements in older adults with knee osteoarthritis. Participants were hypothesized to experience improved pain measurements over time. Design Open-label, single-arm trial. Setting Southeast Texas between March and November 2018 at a nursing school and participant homes. Subjects Older adults (aged 50–85 years) with self-reported unilateral or bilateral knee osteoarthritis pain who met eligibility criteria set by the American College of Rheumatology. Methods The intervention was applied with a constant current intensity for 20 minutes every weekday for two weeks (10 total sessions). Quantitative measures of pain were collected three times over 10 days (days 1, 5, and 10) and included heat threshold and tolerance, pressure pain threshold, punctate mechanical pain, pain, and conditioned pain modulation. Analyses used nonparametric tests to evaluate differences between day 1 and day 10. Generalized linear mixed models were then used to evaluate change across all three time points for each measure. Bayesian inference was used to provide the posterior probability of longitudinal effects. Results Nonparametric tests found improvements in seven measures, and longitudinal models supported improvements in 10 measures, with some nonlinear effects. Conclusions The home-based, remotely supervised intervention improved quantitative measurements of pain in older adults with knee osteoarthritis. This study contributes to the growing body of literature supporting home-based noninvasive stimulation interventions.
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Herbert, Matthew S., Burel R. Goodin, Hailey W. Bulls, Adriana Sotolongo, Megan E. Petrov, Jeffrey C. Edberg, Laurence A. Bradley, and Roger B. Fillingim. "Ethnicity, Cortisol, and Experimental Pain Responses Among Persons With Symptomatic Knee Osteoarthritis." Clinical Journal of Pain 33, no. 9 (September 2017): 820–26. http://dx.doi.org/10.1097/ajp.0000000000000462.

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Ahn, Hyochol, Michael Weaver, Debra E. Lyon, Junglyun Kim, Eunyoung Choi, Roland Staud, and Roger B. Fillingim. "Differences in Clinical Pain and Experimental Pain Sensitivity Between Asian Americans and Whites With Knee Osteoarthritis." Clinical Journal of Pain 33, no. 2 (February 2017): 174–80. http://dx.doi.org/10.1097/ajp.0000000000000378.

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Arazpour, Mokhtar, Tahmoures T. Notarki, Ahmadali Salimi, Monireh A. Bani, Hoda Nabavi, and Stephen W. Hutchins. "The effect of patellofemoral bracing on walking in individuals with patellofemoral pain syndrome." Prosthetics and Orthotics International 37, no. 6 (February 22, 2013): 465–70. http://dx.doi.org/10.1177/0309364613476535.

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Background: Although knee braces are used by individuals with patellofemoral pain syndrome, the effect of patellofemoral bracing on knee flexion during walking has not been elucidated. Aim: The purpose of this study was to evaluate the effect of patellofemoral bracing on sagittal plane knee joint kinematics and temporal spatial parameters during walking in individuals with patellofemoral pain syndrome. Study design: Quasi-experimental. Methods: Ten subjects with a diagnosis of patellofemoral pain syndrome were fitted with a knee brace incorporating an infrapatellar strap. Testing was performed at baseline and after 6 weeks of use. Gait analysis and a visual analog scale were used to assess outcomes in this study. Results: A 59.6% decrease in pain was reported by using bracing. Bracing significantly improved speed of walking ( p ≤ 0.001) and step length ( p ≤ 0.001). The mean cadence was also increased following 6 weeks of patellofemoral brace use, but this was not significant ( p = 0.077). Knee flexion angles improved during initial contact, loading response, and mid-swing ( p ≤ 0.001) after 6 weeks of patellofemoral brace use. Conclusion: Knee orthoses resulted in decreased pain, improved temporal spatial parameters (speed of walking and step length), and increased knee flexion angles during ambulation in patients with patellofemoral pain syndrome. Clinical relevance The results of this study demonstrate a positive effect of patellofemoral bracing in improving specific gait parameters and provide evidence to support its use as a conservative treatment.
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48

García-Marín, Manuel, Daniel Rodríguez-Almagro, Yolanda Castellote-Caballero, Alexander Achalandabaso-Ochoa, Rafael Lomas-Vega, and Alfonso Javier Ibáñez-Vera. "Efficacy of Non-Invasive Radiofrequency-Based Diathermy in the Postoperative Phase of Knee Arthroplasty: A Double-Blind Randomized Clinical Trial." Journal of Clinical Medicine 10, no. 8 (April 10, 2021): 1611. http://dx.doi.org/10.3390/jcm10081611.

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Total knee replacement (TKR) surgery ameliorates knee function and the quality of life of patients, although 20% still experience dissatisfaction due to pain limiting their function. Radiofrequency Diathermy (MDR) has shown improvements in knee osteoarthritis and patellofemoral pain syndrome. As such, this study aims to assess the effects of MDR in the postoperative treatment of TKR patients. Forty-two participants were allocated to an experimental, placebo, or control group. For two weeks, subjects performed daily knee exercises and MDR, knee exercises and placebo MDR, or only knee exercises. Data from the Visual Analogue Scale (VAS), Timed Up-and-Go (TUG) test, Five Times Sit-to-Stand Test (FSST), Western Ontario and McMaster Universities Arthritis Index (WOMAC), physical component summary (PCS), and the mental component summary (MCS) of the SF-12 questionnaire were collected. Group-by-time interaction was significant, with favorable results in the MDR group for VAS (p = 0.009) and WOMAC (p = 0.021). No significant differences were found for TUG, FSST, PCS, or MCS (p > 0.05). In conclusion, the addition of MDR to therapeutic knee exercises obtained better results for knee pain than exercise alone in patients who had recently undergone TKR surgery.
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49

Rondanelli, Mariangela, Valentina Braschi, Clara Gasparri, Mara Nichetti, Milena Anna Faliva, Gabriella Peroni, Maurizio Naso, et al. "Effectiveness of Non-Animal Chondroitin Sulfate Supplementation in the Treatment of Moderate Knee Osteoarthritis in a Group of Overweight Subjects: A Randomized, Double-Blind, Placebo-Controlled Pilot Study." Nutrients 11, no. 9 (August 29, 2019): 2027. http://dx.doi.org/10.3390/nu11092027.

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Osteoarthritis (OA) is the most common form of arthritis in the world and is characterized by pain, various disabilities and loss of quality of life. Chondroitin sulfate (CS) is recommended as first-line therapy. CS of non-animal origin is of great interest for safety and sustainability reasons. This study aims to investigate the anti-inflammatory effects, anti-pain and ability-enhancement of a short-term supplementation with non-animal CS in overweight subjects with OA. In a randomized, double-blind, placebo-controlled pilot study, 60 overweight adults with symptomatic OA were allocated to consume 600 mg of non-animal CS (n = 30) or a placebo (n = 30) daily for 12 consecutive weeks. The assessment of knee-pain, quality of life, related inflammation markers and body composition was performed at 0, 4 and 12 weeks. The Tegner Lysholm Knee Scoring (TLKS) scale of the experimental group showed a statistically significant increase (+10.64 points; confidence interval (95% confidence interval (CI) 5.57; 15.70; p < 0.01), while the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) score decreased (−12.24 points; CI 95% −16.01; −8.38; p < 0.01). The results also showed a decrease in the C-reactive protein (CRP) level (−0.14 mg/dL, CI 95% −0.26; −0.04; p < 0.01) and erythrocyte sedimentation rate (ESR) level (−5.01 mm/h, CI 95% −9.18; −0.84, p < 0.01) as well as the visual analogue scale (VAS) score in both knees. In conclusion, this pilot study demonstrates the effectiveness of non-animal CS supplementation in overweight subjects with knee OA in improving knee function, pain and inflammation markers.
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50

Kissin, Eugene Y., Cristina F. Freitas, and Igor Kissin. "The Effects of Intraarticular Resiniferatoxin in Experimental Knee-Joint Arthritis." Anesthesia & Analgesia 101, no. 5 (November 2005): 1433–39. http://dx.doi.org/10.1213/01.ane.0000180998.29890.b0.

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