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Relevant bibliographies by topics / Fecal biomarker / Dissertations / Theses

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Dissertations / Theses on the topic 'Fecal biomarker'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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1

DeLorenzo, Corrina J. "Evaluating the Use of Fecal Transthyretin as a Biomarker for Noninvasive Pregnancy Diagnosis in the Polar Bear (Ursus maritimus)." University of Cincinnati / OhioLINK, 2017. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1504797886103351.

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2

Motamarri, Srinivas. "Development of a Neural Based Biomarker Forecasting Tool to Classify Recreational Water Quality." University of Cincinnati / OhioLINK, 2010. http://rave.ohiolink.edu/etdc/view?acc_num=ucin1291307369.

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3

Matus, García Mariana Guadalupe. "Analysis of fecal biomarkers to impact clinical care and public health." Thesis, Massachusetts Institute of Technology, 2018. http://hdl.handle.net/1721.1/119603.

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Thesis: Ph. D., Massachusetts Institute of Technology, Computational and Systems Biology Program, 2018.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>DNA sequencing and metabolomics technologies have accelerated the discovery of novel biomarkers in clinical samples. In this thesis, I explore the potential of fecal biomarkers to impact clinical and public health practice through non-invasive assessments. First, I highlight the potential of the gut microbiome to provide novel diagnostic and therapeutic targets. By analyzing the gut microbiome and metabolome

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4

Cheung, Joanna. "Amniotic fluid alkaline phosphatase as a biomarker of fetal growth and development." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=18295.

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The objectives of this study were to assess the concentration of alkaline phosphatase (ALP) and its isoenzymes (intestinal, liver/bone/kidney, placental) in 2nd trimester amniotic fluid (AF) and to establish whether total ALP or placental ALP were related to infant birth weight (BW) or gestational age (GA). 518 biobanked AF samples were analyzed using fluorometry to measure ALP concentrations. Analysis of variance showed that mothers giving birth to small-for-gestational-age infants had higher placental AF ALP concentration compared to those giving birth to appropriate-for-gestational-age infa

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5

Leeming, Rhys, and n/a. "Coprostanol and related sterols as tracers for feacal contamination in Australian aquatic environments." University of Canberra. School of Resource, Environmental & Heritage Sciences, 1996. http://erl.canberra.edu.au./public/adt-AUC20060816.172519.

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Pollution from human and animal faecal waste is a major cause of deteriorating water quality and increased nutrient loads in coastal and inland waterways. Management of this problem depends on knowing which sources of faecal matter are the cause and what is the degree and extent of the pollution. Bacterial indicator organisms have long been the principal method used to test water samples for faecal contamination. However, none of the currently used bacterial indicators on their own are source specific enough to distinguish different sources of faecal matter. The use of faecal sterol biomarkers

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6

Oliver, Reeba. "Changes in cord blood dendritic cells as biomarkers of fetal exposure to stressor stimuli." Thesis, Imperial College London, 2012. http://hdl.handle.net/10044/1/25754.

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DCs are central to fetal defences and it was postulated that phenotypic changes on CBDCs in response to infectious/stressor stimuli could identify compromised fetuses. Investigations were performed on whole blood using monoclonal antibody labelling and flow cytometry. Functional studies included endocytosis of Dextran particles and MLR. Both plasmacytoid (HLA-DR+CD11c−) and myeloid (HLA-DR+CD11c+) DCs were identified in CB. Additionally CB contained a DC subset with a HLA-DR+CD11c−CD45^intermediate(inm) phenotype. This population expressed lower levels of CD45 and HLA-DR and did not express pl

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7

Cannon, Matthew. "Large-scale Investigation of Fetal Hemoglobin Modulators and Inflammation Biomarkers in Sickle Cell Disease." The Ohio State University, 2021. http://rave.ohiolink.edu/etdc/view?acc_num=osu16188574420699.

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8

Higgins, Lucy. "Assessing and quantifying placental dysfunction in relation to pregnancy outcome in pregnancies complicated by reduced fetal movements." Thesis, University of Manchester, 2015. https://www.research.manchester.ac.uk/portal/en/theses/assessing-and-quantifying-placental-dysfunction-in-relation-to-pregnancy-outcome-in-pregnancies-complicated-by-reduced-fetal-movements(49311fd8-8b13-4741-8e60-e150be8765ee).html.

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Currently there is no test to accurately predict stillbirth. It is proposed that better identification of placental disease in utero may aid stillbirth prediction and prevention. Pregnancies complicated by reduced fetal movement (RFM) have increased risk of stillbirth. We hypothesised that RFM is a symptom of placental dysfunction associated with adverse pregnancy outcome (APO) and that this placental abnormality can be detected antenatally and used to identify fetuses at highest-risk of APO. We tested this hypothesis by: 1) comparison of ex vivo placental structure and function between APO RF

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9

El-Halabi, Dima. "Oxidative and nitrative stress biomarkers in amniotic fluid and their association with fetal growth and pregnancy outcomes." Thesis, McGill University, 2007. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=101119.

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The study objectives were to: (1) assess fetal exposure to oxidative stress by measuring amniotic fluid concentrations of nitric oxide (NO), thiobarbituric acid--reactive substances (TBARS), and ferric reducing antioxidant power (FRAP) and (2) establish whether these concentrations were associated with infant birth weight, gestational age, or oxidative stress-related conditions arising during pregnancy. Frozen amniotic fluid samples were obtained from 654 mothers undergoing amniocentesis for genetic testing during second trimester in Montreal, QC, Canada. Maternal and neonatal characteristics

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10

Papadopoulou, Eleni 1985. "Dietary exposure to persistent organic pollutants during pregnancy and child health." Doctoral thesis, Universitat Pompeu Fabra, 2013. http://hdl.handle.net/10803/116933.

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Introduction Diet is the main source of exposure to persistent organic pollutants (POPs), including dioxins and PCBs. During pregnancy the fetus is exposed to POPs which can lead to adverse health effects. The research hypothesis of this thesis is that maternal diet, as a source of prenatal exposure to POPs, may be linked to impaired fetal growth and endocrine disruptive effects. Methods This thesis included 604 mother-child pairs from the European NewGeneris project, 50,651 mother-child pairs from the Norwegian Mother and Child Cohort (MoBa) and 707 mother-child pairs from the Rhea and the

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11

Philippat, Claire. "Utilisation des biomarqueurs d'exposition en épidémiologie environnementale : application à l'étude des effets des expositions intra-utérines aux phénols et au phtalates sur la croissance pré-et post-natale." Thesis, Grenoble, 2013. http://www.theses.fr/2013GRENS014/document.

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Contexte : Les phtalates et les phénols sont des perturbateurs endocriniens. Les données concernant leurs effets sur la croissance fœtale et durant l'enfance sont limitées et suggèrent un effet dépendant du sexe de certains phénols sur le poids de naissance. Une des limites de ces études est l'estimation de l'exposition, basée sur la mesure de leurs concentrations dans un petit nombre d'échantillons d'urine maternelle. En raison de la faible persistance de ces composés chimiques dans l'organisme, les concentrations urinaires varient dans le temps. Les concentrations dosées dans d'autres matric

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12

Machtejevienė, Eglė. "Peptide pattern of amniotic fluid and its correlation with protein composition of fetal membranes: the search for new potential biomarkers to predict preterm premature rupture of membranes." Doctoral thesis, Lithuanian Academic Libraries Network (LABT), 2013. http://vddb.laba.lt/obj/LT-eLABa-0001:E.02~2013~D_20130919_143805-88333.

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The aim of the research was to find new potential biomarkers of preterm premature rupture of membranes. The amniotic fluid and fetal membranes peptidic composition was analyzed using a fully automated 2D liquid chromatographic system coupled to mass spectrometry. A comparison of peptidomes of amniotic fluid and amniochorionic membranes with preterm premature rupture and term intact membranes was performed. Ten proteins from amniotic fluid were identified as potential biomarkers for PPROM. The created map of amniotic fluid peptides and proteins depending on the gestational age is important for

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13

Kultima, Kim. "Transcriptomics and Proteomics Applied to Developmental Toxicology." Doctoral thesis, Uppsala : Acta Universitatis Upsaliensis, 2007. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-7921.

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14

Moxley, Erika Michelle. "Serial fecal biomarker measurements predict response to biologic therapy in children with IBD." Thesis, 2019. https://hdl.handle.net/2144/36580.

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INTRODUCTION: The techniques currently in practice to diagnose and assess interval disease activity in patients with inflammatory bowel disease (IBD) are costly and invasive. Physicians typically rely on information derived from a combination of endoscopic, radiologic, and histologic studies to diagnose and determine the extent and severity of the two most common forms of IBD, Crohn disease (CD) and ulcerative colitis (UC). The development of noninvasive methods of assessing response to therapy is of increasing importance to pediatric healthcare providers. Previous studies have demonstrated th

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15

Murphy, Sean Thomas. "Changes in fecal lactoferrin as a predictor of of steroid responsiveness in pediatric patients with ulcerative colitis." Thesis, 2016. https://hdl.handle.net/2144/16998.

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INTRODUCTION: The management of pediatric patients with ulcerative colitis (UC) is dependent upon the ability to detect meaningful changes in disease status. This is currently done using validated patient-reported clinical disease activity indices, including the Pediatric Ulcerative Colitis Activity Index (PUCAI). While useful for global assessments completed during ambulatory office visits, the sensitivity of this metric may be insufficient to reflect more subtle changes in disease activity or response to medical therapy in hospitalized patients. Intravenous steroids are typically employed in

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16

Mandehr, Kellen Franklyn. "The utility of fecal lactoferrin measurements in predicting disease activity of hospitalized patients with ulcerative colitis." Thesis, 2014. https://hdl.handle.net/2144/14313.

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BACKGROUND: Early identification of pediatric patients with Inflammatory Bowel Disease (IBD), including ulcerative colitis and Crohn disease, is important to help clinicians design optimal treatment regimens. Existing endoscopic techniques are effective in identifying disease activity. However, these methods are invasive, expensive, and less amenable to serial measurement. Recent studies have identified potential serologic and fecal biomarkers that may have the potential to provide clinicians with a more objective evaluation of disease activity. In the case of ulcerative colitis (UC), in w

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17

Mojdehbakhsh, Rachel. "Serial fecal ASCA measurements in the evaluation of children with Crohn's disease." Thesis, 2015. https://hdl.handle.net/2144/16025.

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BACKGROUND: Pediatric patients with Inflammatory Bowel Disease (IBD) undergo costly and invasive investigations to diagnose and treat their chronic disease. To that end, it is important for researchers and physicians to continue to work to find novel tools to improve diagnosis and treatment processes. One of the main challenges is differentiating between the two main forms of IBD, Crohn disease (CD) and ulcerative colitis (UC). Physicians currently rely on a combination of endoscopic evaluations, mucosal biopsies, radiology studies, and biochemical testing to assess for the presence and extent

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18

Leonardo, Trevor Robert Thomas. "Extracellular RNAs as potential biomarkers for placental dysfunction." Thesis, 2014. https://hdl.handle.net/2144/14367.

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Placental dysfunction affects approximately 1 in 10 pregnant women in both the developed and developing worlds. Most commonly, it is manifested as preeclampsia or fetal growth restriction. Over the past two decades, an increasing body of research into the developmental biology of the placenta has been amassed, which points to defects in the differentiation of the trophoblast cell lineage as a key player in the pathophysiology of placental dysfunction. A number of clinical parameters are known to be associated with an elevated risk of placental dysfunction. These include maternal risk factors (

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19

Zapata, Juliana Maria. "Serial changes in serum and fecal biomarkers levels in pediatric patients with IBD treated with remicade." Thesis, 2018. https://hdl.handle.net/2144/31309.

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INTRODUCTION: Patients with Inflammatory Bowel Disease (IBD) undergo costly and invasive procedures in efforts to both diagnose and monitor their disease. Healthcare providers rely on endoscopic and radiologic studies, mucosal biopsies, and biochemical testing to stage a particular patient’s disease type and severity. Efforts to lower both the cost and morbidity associated with these evaluations are in demand, especially with respect to testing in pediatric patients. Serum and fecal biomarkers hold great potential in providing non-invasive, cost effective, and safer methods of diagnosis and as

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20

Kim, Jochebed. "Serum and fecal biomarkers predict response to Infliximab therapy in pediatric patients with Inflammatory Bowel Disease." Thesis, 2020. https://hdl.handle.net/2144/41280.

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Inflammatory Bowel Disease (IBD) is a chronic, idiopathic autoimmune disease characterized by the inflammation of the GI tract. The main subcategories of IBD include Crohn Disease (CD), ulcerative colitis (UC), and Indeterminate Colitis (IC). Currently, IBD is diagnosed and evaluated using clinical, endoscopic, biochemical, and histologic measures - which can be invasive and costly. Previous studies have shown that measurement of serum and fecal inflammatory biomarkers might be effective both for the assessment of intestinal infectious or inflammatory processes, as well as for gauging IBD dise

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21

Kulaga, Vivian. "Fatty Acid Ethyl Esters (FAEE), A Biomarker of Alcohol Exposure: Hope for a Silent Epidemic of Fetal Alcohol Affected Children." Thesis, 2008. http://hdl.handle.net/1807/17788.

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One percent of children in North America may be affected by fetal alcohol spectrum disorder (FASD). FASD remains difficult to diagnose because confirmation of maternal alcohol use is a diagnostic criterion, and women consuming alcohol during pregnancy are reluctant to divulge this information for fear of stigmatization and losing custody of the child. Consequently, using a biomarker to assess alcohol exposure would provide a tremendous advantage. Recently, the measurement of fatty acid ethyl ester (FAEE) in hair has provided a powerful tool for assessing alcohol exposure. My thesis fills a t

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22

Rogerson, Sara M. "Use of fecal and serologic biomarkers in the prediction clinical outcomes in children presenting with abdominal pain and/or diarrhea." Thesis, 2017. https://hdl.handle.net/2144/23992.

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INTRODUCTION: Abdominal pain and diarrhea are two of the most common pediatric complaints. They are often associated with a diagnosis of Crohn Disease or Ulcerative Colitis, collectively known as inflammatory bowel disease (IBD). IBD is set of diseases with ill-defined pathogenesis but similar clinical presentation. Clinicians rely on colonoscopic evaluation to distinguish between the two disorders, and the rate of colonoscopies has been increasing over the past several years. With the risks and costs associated with colonoscopic evaluation, our study sought to identify physiologic variables w

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23

Zelner, Irene. "Screening for Prenatal Alcohol Exposure using Fatty Acid Ethyl Esters as Biomarkers." Thesis, 2013. http://hdl.handle.net/1807/43771.

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Diagnosis of fetal alcohol spectrum disorders (FASD) is challenging and typically requires confirmation of in utero alcohol exposure. Due to the poor reliability of maternal self-reports, biomarkers have emerged to address the problem of obtaining exposure history. A relatively novel method for detecting prenatal alcohol exposure is analysis of meconium for fatty acid ethyl esters (FAEEs), which are non-oxidative ethanol metabolites. Screening newborns using meconium FAEEs may facilitate early diagnosis and intervention in alcohol-affected individuals. The overall objective of this thesis is

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