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Journal articles on the topic 'Floating lag time'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Mohammad, Rafivulla, Saketh Darisi, Pushpanjali Chowtipalli, Yohan Gangolu, Meghamala Gajula, and Rao Vadapalli* Rama. "A REVIEW OF THE ANALYSIS OF ANTIHISTAMINE MEDICATION FLOATING TIMES FOR EFFICIENCY EVALUATION." World Journal of Pharmaceutical Science and Research 3, no. 6 (2024): 68–80. https://doi.org/10.5281/zenodo.14252479.

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The purpose of a gastroretentive drug delivery system (GRDDS) is to increase drug absorption and bioavailability by extending the period of time that pharmaceuticals are in the stomach. This technique is especially helpful for medications with upper absorption windows digestive system or those that break down in the stomach's acidic environment. GRDDS can decrease dosage frequency and enhance therapeutic effects by prolonging a drug's gastrointestinal half-life.This review demonstrates a correlation between diminishing floating capabilities and the stomach residence time of antihistamine medic

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Darisi, Saketh1 Gangolu Yohan2 Gurram Lokeswari3 Bodapati Meghana4 Jayanth Kandula5 Dr. Rama Rao Vadapalli6*. "Analyzing Antihypertensive Drugs Floating Times for Efficiency Evaluation: A Review." International Journal of Pharmaceutical Sciences 3, no. 3 (2025): 1801–15. https://doi.org/10.5281/zenodo.15049315.

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Objective: This review aims to evaluate the efficacy of Gastroretentive Drug Delivery Systems (GRDDS) in enhancing the gastric residence time of antihypertensive drugs to improve drug absorption and bioavailability. Methods: The study analyzed various GRDDS formulations designed to prolong gastric residence time. Key parameters such as Total Floating Time and Floating Lag Time were measured to assess the sustained release capabilities of these formulations. A comparative analysis was conducted across different antihypertensive drugs, focusing on their floating capacities in simulated gastric f

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Aisiyah, Siti, Achmad Fudholi, and Abdul Rohman. "Optimasi Formula Tablet Floating Nifedipin Menggunakan HPMC K15M, PVP K-30 dan Avicel PH 102 dengan Metode Simplex Lattice Design." Jurnal Farmasi (Journal of Pharmacy) 2, no. 1 (2019): 30. http://dx.doi.org/10.37013/jf.v2i1.17.

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Nifedipin merupakan obat dengan kelarutan kecil dalam air sehingga kelarutan nifedipin perlu ditingkatkan dengan penambahan PVP K-30. Penelitian ini bertujuan untuk mengetahui pengaruh HPMC K15M, PVP K-30 terhadap pelepasan nifedipin, dan Avicel PH 102 terhadap floating lag time tablet floating nifedipin, serta untuk mengetahui proporsi masing-masing bahan untuk membuat formula optimum tablet floating nifedipin. Penelitian dilakukan dengan metode simplex lattice design (SLD) dengan 3 komponen yaitu HPMC K15M, PVP K-30 dan Avicel PH 102 sehingga diperoleh 14 formula. Parameter optimasi terdiri

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Sandeep, A. Wathore *. Vijaykumar M. Kale Yuvraj L. Pandhare. "FORMULATION AND EVALUATION OF FLOATING TABLETS OF CEFUROXIME AXETIL." Journal of Pharma Research 8, no. 8 (2019): 544–49. https://doi.org/10.5281/zenodo.3374079.

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<strong><em>ABSTRACT</em></strong> <strong><em>T</em></strong><em>he objective of research work was to formulate and evaluate the floating drug delivery system containing cefuroxime axetil using polymer HPMC K4M, Guar Gum.  Effervescent floating tablets containing Cefuroxime axetil were prepared by direct compression technique using varying concentrations of different grades of polymer. Physical parameters like hardness, weight variation, thickness and friability were within pharmacopoeial limit. Percentage drug content in all floating tablet formulations was found to be 90% to 110%. The

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Patel, Keyur S., Akshar N. Rao, Deepa R. Patel, Dhaval M. Patel, and Advaita B. Patel. "Formulation and Evaluation of Gastroretentive Floating Tablets of Quetiapine Fumarate." Journal of Drug Delivery and Therapeutics 11, no. 3-S (2021): 65–73. http://dx.doi.org/10.22270/jddt.v11i3-s.4833.

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The objective of the present study was to develop gastroretentive floating tablets of quetiapine fumarate. The gastroretentive floating tablets of quetiapine fumarate were formulated using natrosol 250 HHX as a sustained release polymer and sodium bicarbonate as a gas forming agents. A 32 factorial design was employed to study the influence of concentration of natrosol HHX 250 (X1) and concentration of sodium bicarbonate (X2) on the dependent variables % drug release at 1h (Y1), % drug release at 8 h (Y2) and floating lag time (Y3). The optimized formulation (O1) showed floating lag time 49 ±

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Patel, Upasana J., Hitesh kumar A. Patel, Bhumika J. Limbachiya, and Mehzabeen Jhankhwala. "Formulation, development and optimization of gastroretentive floating pellets of febuxostat." Journal of medical pharmaceutical and allied sciences 11, no. 1 (2022): 4317–23. http://dx.doi.org/10.55522/jmpas.v11i1.2095.

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The aim of the study was to develop gastro retentive floating pellets of febuxostat used to treat gout condition which having low solubility and high bioavailability. The gastro retentive floating pellets of febuxostat were formulated using Gelucire 43/01 and ethyl cellulose as a sustain release polymer and microcrystalline cellulose as spheronizing agent by extrusion- spheronization technique. A 32 full factorial design was applied to investigate the effect of the two-independent variable, that is, ratio of Drug: Gelucire (X1) and ratio of Drug: ethyl cellulose (X2), on the dependent variable

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Tania, Alinda, Fitrya Fitrya, and Najma Fithri. "FORMULASI DAN EVALUASI TABLET SISTEM GASTRORETENTIF EKSTRAK DAUN PETAI (Parkia speciosa Hassk.) MENGGUNAKAN HPMC-K4M DAN CARBOPOL® 934P." ISTA Online Technologi Journal 4, no. 2 (2023): 01–17. http://dx.doi.org/10.62702/ion.v4i2.85.

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Tukak peptik adalah luka yang dapat terjadi pada lambung dan usus halus bagian atas dengan prevalensi 6 – 15% terutama pada usia 20 – 50 tahun. Obat-obatan sintetis masih menjadi pilihan utama dalam pengobatan, namun ada banyak tanaman yang diketahui berkhasiat sebagai obat antitukak. Salah satu tanaman yang berkhasiat sebagai antitukak adalah petai (Parkia speciosa). Daun petai dapat diformulasi menjadi tablet floating-mucoadhesive dengan polimer HPMC-K4M dan Carbopol®934P, sehingga pelepasan obat tertarget di saluran pencernaan atas. Penelitian ini bertujuan untuk mengetahui pengaruh komposi

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Gaur, A., and H. P. Shah. "Formulation, Development and Evaluation of floating tablet of Metformin Hydrochloride using optimization of gas generating agent." Formulation, Development and Evaluation of floating tablet of Metformin Hydrochloride using optimization of gas generating agent 1, no. 3 (2011): 26–31. https://doi.org/10.5281/zenodo.12699386.

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The present study deals with drug release enhancement of MetforminHydrochloride using floating technology by optimization of gas generating agent to improvethe buoyancy time. Metformin hydrochloride is a oral antihyperglycemic agent of biguanideclass used in treatment of type 2 Diabetes. It is hydrophilic drug which absorbed slowly andnot completely form the gastrointestinal tract. The absolute bioavailability is reported to be50-60%. This technology uses direct compression method to prepare floating tablet ofMetformin Hydrochloride with release retardant polymer HPMC K-100, PVP K-30, Carbopol

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9

K R, Shankar, Aminabee S, Ramana G, Lakshmi KNVC, and Indusree G. "Formulation and Evaluation of Propranolol Hydrochloride Floating Tablets by 32 Factorial Design." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 14, no. 04 (2024): 1716–21. https://doi.org/10.25258/ijddt.14.4.17.

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The goal of current work is to develop Propranolol HCl floating tablets. Floating tablets of Propranolol HCl were designed basing on the idea of gas generation. Using sodium bicarbonate (NaHCO3) as a gas-generating agent, xanthan gum, polyox WSR 303a as a matrix-forming polymer, and HPMC K4 M and K15 M as matrix-forming polymers, matrix tablets totalling 40 mg of propranolol HCl were created.Among the four polymers namely HPMCK4M, HPMCK15M, Xanthan gum and Polyox WSR, HPMC K4M gave good release and was selected for formulation of propranolol HCl floating tablets by 32 factorial design. Propran

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Tripathi, Ankita, Suraj Neupane, Khushboo Bhardwaj, Shiva Mishra, Meenakshi Gupta, and Raj Kumar Mishra. "FLOATING DRUG DELIVERY SYSTEM OF NSAIDS TO INCREASE GASTRIC RETENTION TIME IN UPPER PART OF GASTROINTESTINAL TRACT." International Research Journal of Pharmacy 12, no. 1 (2021): 33–39. http://dx.doi.org/10.7897/2230-8407.1201115.

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The purpose of the present work is to prolong the gastric residence time of Lornoxicam by developing gastric floating drug delivery system. Lornoxicam is non-steroidal anti-inflammatory drugs. Its short half life 2 to 3 hrs and maximal absorption of upper part of gastrointestinal tract. The residence time of the dosage form in the stomach depends upon various factors like pH, size of the dosage form, food intake, and biological factors which include age, body weight gender, posture, and diseased states Floating tablet prepared by melt granulation techniques, using bees wax as a binder and the

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Bhaskar, Shrestha Sajan Maharjan* Himal Chhetry Panna Thapa. "Formulation and in vitro evaluation of floating pulsatile drug delivery system of Atenolol based on coated effervescent core." Int. J. in Pharm. Sci. 1, no. 8 (2023): 140–51. https://doi.org/10.5281/zenodo.8249869.

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Present research work attempts to design, formulate and optimize the floating pulsatile drug delivery system (FPPDS) intended to treat nocturnal hypertension. FPPDS was designed based on central reservoir system containing effervescent agent with rupturable coating and a buoyant layer on top of the coated core. This system consists of rapid release core that contains drug with disintegrants, osmogent (sodium chloride) and effervescent agent (sodium bicarbonate and tartaric acid) which was film coated by hydrophobic polymer Ethyl Cellulose(EC) with polyethylene Glycol(PEG) 6000 as a plasticizer

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Rakesh Mishra, Pavan Suradkar, and Tanaji Nandgude. "Statistical design and optimization of ketorolac tromethamine gastroretentive multiparticulate delivery system." International Journal of Research in Pharmaceutical Sciences 10, no. 3 (2019): 2399–408. http://dx.doi.org/10.26452/ijrps.v10i3.1486.

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The aim of the present research is to design and optimize floating multiparticulate drug delivery system of Ketorolac tromethamine (KT) so as to reduce its irritant effect on the gastric mucosa. Extrusion and spheronization process were used to prepare a drug-containing core pellets. A 3 level 2 experimental factor design was used to examine the effect of the amount of Eudragit RS 100, effervescent agent (NaHCO3: HPMC K4M) on floating lag time and drug release in 6 h. Fourier Transform Infra-Red (FTIR) spectrum, physical characterization, particle size distribution analysis, scanning electron

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Pathak, Sudhakar, Harish Pandey, and Sunil Kumar Shah. "Formulation and Evaluation of Floating Matrix Tablets of Sacubitril and Valsartan." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 298–309. http://dx.doi.org/10.22270/jddt.v9i4-s.3322.

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Floating Drug Delivery Systems (FDDS) have a bulk density lower than gastric fluids and thus remain buoyant in the stomach for a prolonged period of time, without affecting the gastric emptying rate. While the system is floating on the gastric contents, the drug is released slowly at a desired rate from the system. These floating tablets mainly prepared for reduction of lag time and release the drug up to 12 hours and may also increase the bioavailability of the drugs by utilizing the drug to full extent avoiding unnecessary frequency of dosing. The purpose of this research was to develop and

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Goyal, Anil K., and Vinesh Kumar. "In-vitro Evaluation and Optimization of Sacubitril and Valsartan Floating Tablet using Natural Polymer." INTERNATIONAL JOURNAL OF DRUG DELIVERY TECHNOLOGY 13, no. 04 (2023): 1454–58. http://dx.doi.org/10.25258/ijddt.13.4.51.

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Oral systems have become gradually extensive for human consumption because of their numerous advantages, such as formulation efficiency, cost-effectiveness, and patient safety compliance. These systems offer a versatile platform for controlled drug release, allowing precise targeting of absorption site in the gastrointestinal tract. Accomplishing ideal therapeutic results for certain medications often requires precise control of drug release at specific locations within the gastrointestinal tract. In this study, our goal was to create a floating drug delivery system for two vital cardiovascula

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Masareddy, Rajashree, Pradnya Sandure, Archana Patil, Yadishma Gaude, and Arpana Patil. "In situ gastric floating gel of atazanavir sulphate for sustained release: formulation, optimization and evaluation." Therapeutic Delivery 14, no. 10 (2023): 619–33. http://dx.doi.org/10.4155/tde-2023-0037.

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Aim: Atazanavir sulphate belongs to BCS class II drug, its oral bioavailability is limited due to its rapid first-pass metabolism and P-gp efflux. Materials & methods: The in situ floating gel using the complexed drug was prepared by ion gelation method and optimized the formulation as per 32 full factorial design. Results: Floating lag time of optimized formulation was found to be 18 s and percentage drug release of 94.18 ± 0.18 % at the end of 16 h. The concentration of gelling polymer affects drug release and a floating lag time and vice versa. Conclusion: In situ floating gel of atazan

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Haq, S. Muhammed Fazal ul, and Kankanala Ashwitha. "Formulation and Evaluation of Guaifenesin Gastro Retentive Tablets." Saudi Journal of Medical and Pharmaceutical Sciences 8, no. 9 (2022): 479–84. http://dx.doi.org/10.36348/sjmps.2022.v08i09.007.

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Guaifenesin is an expectorant and belongs to BCS class I which exhibits high solubility and high permeability. Guaifenesin has a half-life of 1 hour; in order to increase its duration of action gastroretentive tablets are formulated. Guaifenesin shows poor flow properties so the method opted for the preparation of this tablets is Top spray granulation. In which HPMC K100LV/HPMC E6LV/HPMC K100M/HPMC K15MPCR is used as swelling matrix polymer, Povidone is used as binder, Magnesium stearate is used as lubricant and MCC is used as diluent. Tablets are evaluated for floating lag time, total floatin

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Munagala Gayatri Ramya and Kothapalli Bannoth Chandra Sekhar. "Preparation and evaluation of matrix type gastro retentive floating atenolol tablets using sintering technique." International Journal of Research in Pharmaceutical Sciences 11, no. 2 (2020): 1920–26. http://dx.doi.org/10.26452/ijrps.v11i2.2109.

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The aim of this investigation was to design and assess the gastric floating tablets of Atenolol using thermal sintering and investigate the effect of sintering on PEO polymer. Atenolol is an Antihypertensive with only 50 percent bioavailability due to poor absorption in lower GI tract. Gastro retentive Floating tablets were prepared to enhance the gastric retention time, to prolong the drug release. PEO which was selected as sintered polymer. Tablets were prepared by direct compression method .Formulated tablets were exposed to different temperatures (400C, 500C and 600C) at various time inter

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Salunkhe, Pranali Shivaji. "FORMULATION AND EVALUATION OF GASTRORETENTIVE TABLETS OF ANTIULCER DRUG." Asian Journal of Pharmaceutical and Clinical Research 9, no. 6 (2016): 48. http://dx.doi.org/10.22159/ajpcr.2016.v9i6.10360.

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ABSTRACTGastroretentive floating drug delivery system is utilised to target drug release in the stomach or to the upper part of intestine. Lansoprazole is proton pump inhibitor intended for oral administration used as antiulcer agent. The present investigation involved formulation and evaluation of Gastroretentive floating tablets of Lansoprazole for prolongation of gastric residence time with a view to deliver the drug at sustained and controlled manner in gastrointestinal tract. The tablets of Lansoprazole were prepared by direct compression method using gas generating agent and different po

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Journal, Devanshi, Dibya Kumari, and Umesh Kumar Jain. "Formulation and Evaluation of Gastroretentive Bilayer Tablets." Journal of Drug Delivery and Therapeutics 14, no. 9 (2024): 107–12. http://dx.doi.org/10.22270/jddt.v14i9.6784.

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Gastroretentive bilayer tablets were designed to prolong the gastric residence time after oral administration and to achieve immediate release of lansoprazole and controlled release floating layer of clarithromycin to treat gastric ulcers. Instant release layer has a combination of super disintegrating agents. A combination of effervescent mechanism is used. HPMC K5 was used as swelling polymer and citric acid, sodium bicarbonate as gas generating agent to reduce the floating lag time. Bilayer floating tablets were prepared with varying proportions of instant layer and sustained release floati

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Armadani, Valentina Ayuk, Siti Aisiyah, and Ilham Kuncahyo. "PENGARUH MATRIKS PEKTIN DAN HPMC K15M TERHADAP DAYA MENGAPUNG DAN MENGEMBANG SERTA DISOLUSI PADA TABLET FLOATING VERAPAMIL HCl DENGAN METODE FACTORIAL DESIGN." Jurnal Farmasi (Journal of Pharmacy) 9, no. 1 (2020): 27–35. http://dx.doi.org/10.37013/jf.v9i1.100.

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Verapamil HCl merupakan penghambat kanal Ca2+ untuk terapi hipertensi dan angina pectoris. Verapamil HCl memiliki bioavabilitas 10-20% dan waktu paruh 4 jam sehingga dapat dibuat sediaan gastroretentive untuk mempertahankan kadar terapi obat. Penelitian ini bertujuan mengetahui pengaruh matriks pektin dan HPMC K15M terhadap kemampuan mengapung, mengembang dan pelepasan obat pada tablet floating verapamil HCl.Penelitian ini menggunakan empat formula variasi konsentrasi matriks pektin dan HPMC K15M dengan metode kempa langsung kemudian dilakukan pengujian terhadap sifat fisik serbuk dan tablet.

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Rohit Jaimini and Dr. Manish Jaimini. "FORMULATION AND OPTIMIZATION OF GASTRO-RETENTIVE FLOATING TABLETS OF ENALAPRIL MALEATE AND LOSARTAN FOR ENHANCED BIOAVAILABILITY AND THERAPEUTIC EFFICACY." Tropical Journal of Pharmaceutical and Life Sciences 12, no. 1 (2025): 01–10. https://doi.org/10.61280/tjpls.v12i1.170.

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The objective of this study was to formulate and optimize gastro-retentive floating tablets of Enalapril Maleate and Losartan to enhance their bioavailability and therapeutic efficacy. These drugs, commonly used in the management of hypertension and heart failure, suffer from limited solubility and rapid gastric emptying, which reduce their effectiveness. Gastro-retentive floating tablets were developed using hydroxypropyl methylcellulose (HPMC K4M) and guar gum as release-controlling agents, with sodium bicarbonate and citric acid as effervescent agents to ensure buoyancy. Twenty formulations

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Deshmukh, Aishwarya V., Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." Der Pharma Chemica 15, no. 6 (2023): 4. https://doi.org/10.5281/zenodo.13353444.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Aishwarya, V. Deshmukh, Gawande SR, and Chandewar AV. "Review on: Floating Drug Delivery System." DER PHARMA CHEMICA 15, no. 6 (2023): 4. https://doi.org/10.4172/0975-413X.15.6.142-146.

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Floating matrix tablets were developed to prolong gastric residence time and increase drug absorption further increasing the bioavailability. Various forms of gastro retentive drug delivery system, such as floating and non-floating. Floating tablets was formulated to increase gastric residence and there by improve its therapeutic efficacy. By using different polymers such as carbopol, guargum, HPMC K100, HPMCK4 etc. Formulated tablets showed satisfactory results for various post compression evaluation parameters like thickness, hardness, weight variation, floating lag time, total floating time

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Dolas, Ramdas T., Shalindra Sharma, and Madhuraj Sharma. "FORMULATION AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF LAFUTIDINE." Journal of Drug Delivery and Therapeutics 8, no. 5 (2018): 393–99. http://dx.doi.org/10.22270/jddt.v8i5.1898.

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The purpose of this research was to develop a novel gastroretentive drug delivery system based on wet granulation technique for sustained delivery of active agent. Quick GI transit could result in incomplete drug release from the drug delivery system above the absorption zone leading to decreased efficacy of the administered dose and thus less patient compliance. Gastroretentive floating tablets, which was designed to provide the desired sustained and complete release of drug for prolonged period of time. Gastroretentive floating tablets of lafutidine were prepared by wet granulation technique

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Singh, Maninder Pal, Manish Kumar, and Ravi Shankar. "Development and Optimization of Methscopolamine Bromide Gastroretentive Floating Tablets Using 32 Factorial Design." Drug Research 70, no. 12 (2020): 576–82. http://dx.doi.org/10.1055/a-1249-8186.

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Abstract Purpose The aim of this study was to formulate methscopolamine floating drug delivery system to increase its gastro retention for further enhancement of absorption and overall bioavailability. Method Direct compression method was used to formulate floating drug delivery system of methscopolamine bromide. Different amount of HPMC, PVP K25, and MCC were used for preparation of tablets. Result The prepared tablets were evaluated for thickness, hardness, weight variation, floating lag time, swelling index and in-vitro drug release. All the formulations showed less than 10% of weight varia

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Varshi, Reena, Vikas Jain, Pradeep Pal, and Narendra Gehalot. "Formulation and Evaluation of Extended Release Gastroretentive Tablets of Metroprolol Succinate." Journal of Drug Delivery and Therapeutics 12, no. 5-S (2022): 127–32. http://dx.doi.org/10.22270/jddt.v12i5-s.5653.

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This study aimed to produce a gastroretentive floating tablet of Metoprolol succinate and examine the effects of release retardant on in vitro drug release. Metoprolol succinate is a β1 selective antagonist used as an Anti-hypertensive, Antiarrhythmic, and Anti Angina. Metoprolol succinate has 48% oral bioavailability due to limited absorption from the lower gastrointestinal tract. The Metoprolol succinate floating tablets were designed to increase stomach retention, prolong drug release, and enhance drug bioavailability. To shorten the floating lag time, hydrophilic polymers like Hydroxypropy

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K., Srinivasa Reddy Surya Kanta Swain K. P. R. Chowdary *. and S.V.U.M. Prasad. "FORMULATION DEVELOPMENT OF SUSTAINED RELEASE FLOATING TABLETS OF VALSARTAN: OPTIMIZATION BY 22 FACTORIAL DESIGN." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 06 (2018): 6023–29. https://doi.org/10.5281/zenodo.1303394.

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The objective of the present study is optimization of valsartan SR floating tablet formulation by 22 factorial design. SR floating tablets of valsartan (80 mg) were formulated employing HPMCK100M as matrix forming polymer, sodium bicarbonate as gas generating agent and beeswax and ethyl cellulose as floating enhancers. Valsartan is an orally active anti-hypertensive drug, majorly absorbed from stomach and upper small intestine. Formulation of sustained release floating tablets of valsartan is needed because of its poor oral bioavailability and short biological half-life. Valsartan floating tab

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Siti Mursidatur Rohmah, Dewi Rashati,. "UJI FISIK FORMULASI TABLET FLOATING TEOFILIN DENGAN MATRIK HPMC." JURNAL ILMIAH FARMASI AKADEMI FARMASI JEMBER 1, no. 1 (2021): 13–20. http://dx.doi.org/10.53864/jifakfar.v1i1.6.

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The purpose of this study was to determine the physical properties of theophylline floating tablet formulation with HPMC as matrix. Floating tablets of theophylline is manufactured by direct compression. Composition per tablet formulation consisting of theophylline 270 mg, HPMC, avicel, magnesium stearate, and sodium bicarbonate. The results of data showed average of tablet weight uniformity 501mg, tablet hardness 6,99 kg, tablet friability 0,593%, disintegration time of tablets 738 seconds, floating lag time (FLT) 584,3 seconds and floating duration time (FDT) more than 8 hours. Floating tabl

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Pawar, Harshal Ashok, Pooja Ramchandra Gharat, Rachana Vivek Dhavale, Pooja Rasiklal Joshi, and Pushpita Pankajkumar Rakshit. "Development and Evaluation of Gastroretentive Floating Tablets of an Antihypertensive Drug Using Hydrogenated Cottonseed Oil." ISRN Pharmaceutics 2013 (December 18, 2013): 1–9. http://dx.doi.org/10.1155/2013/137238.

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The aim of the present work was to develop a gastroretentive floating tablet of Atenolol and investigate the effects of both hydrophilic and hydrophobic retardant on in vitro release. Atenolol is an antihypertensive drug with an oral bioavailability of only 50% because of its poor absorption from lower gastrointestinal tract. The floating tablets of Atenolol were prepared to increase the gastric retention, to extend the drug release, and to improve the bioavailability of the drug. The floating tablets were formulated using hydrophilic polymers as Hydroxy propyl methyl cellulose (HPMC K4M and H

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Patle, Bharti, Vivek Jain, Shradha Shende, and Prabhat Kumar Jain. "Formulation Development and Evaluation of Sustain Release Gastroretentive Floating Tablets of Prochlorperazine Dimaleate." Journal of Drug Delivery and Therapeutics 9, no. 4-s (2019): 445–50. http://dx.doi.org/10.22270/jddt.v9i4-s.3353.

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Floating drug delivery systems are the gastroretentive forms that precisely control the release rate of target drug to a specific site which facilitate an enormous impact on health care. The purpose of this research was to develop a novel gastro retentive drug delivery system based on direct compression method for sustained delivery of active agent to improve the bioavailability, reduce the number of doses and to increase patient compliance. Gastro retentive floating tablets of Prochlorperazine dimaleate (PCZ) were prepared by direct compression method using altered concentrations of HPMC K4,

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Jagdale, Swati C., and Chandrakala R. Pawar. "Application of Design of Experiment for Polyox and Xanthan Gum Coated Floating Pulsatile Delivery of Sumatriptan Succinate in Migraine Treatment." BioMed Research International 2014 (2014): 1–10. http://dx.doi.org/10.1155/2014/547212.

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Migraine follows circadian rhythm in which headache is more painful at the awakening time. This needs administration of dosage form at night time to release drug after lag period when pain gets worse. Sumatriptan succinate is a drug of choice for migraine. Sumatriptan succinate has bitter taste, low oral bioavailability, and shorter half-life. Present work deals with application of design of experiment for polyox and xanthan gum in development of press coated floating pulsatile tablet. Floating pulsatile concept was applied to increase gastric residence of the dosage form. Burst release was ac

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Vinogradov, V. P., and E. V. Blynskaya. "Optimization of the composition and technology for the production of flotation tablets of sitagliptin with modified release." Farmacevticheskoe delo i tehnologija lekarstv (Pharmacy and Pharmaceutical Technology), no. 4 (September 6, 2024): 19–30. http://dx.doi.org/10.33920/med-13-2404-02.

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The article presents the results of the study of the influence of critical material attributes and process parameters for obtaining modified release sitagliptin floating tablets, as well as the optimization of the factor values using the surface response method and the generalized desirability function. In accordance with the three-factor three-level Box-Behnken plan, the tests of dosage forms were carried out, the values of the quality attributes - «floating lag time», the coefficient of determination of compliance with the kinetics of the zero-order release model, total release, tablet hardn

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Reddy Dumpa, Nagi, Suresh Bandari, and Michael A. Repka. "Novel Gastroretentive Floating Pulsatile Drug Delivery System Produced via Hot-Melt Extrusion and Fused Deposition Modeling 3D Printing." Pharmaceutics 12, no. 1 (2020): 52. http://dx.doi.org/10.3390/pharmaceutics12010052.

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This study was performed to develop novel core-shell gastroretentive floating pulsatile drug delivery systems using a hot-melt extrusion-paired fused deposition modeling (FDM) 3D printing and direct compression method. Hydroxypropyl cellulose (HPC) and ethyl cellulose (EC)-based filaments were fabricated using hot-melt extrusion technology and were utilized as feedstock material for printing shells in FDM 3D printing. The directly compressed theophylline tablet was used as the core. The tablet shell to form pulsatile floating dosage forms with different geometries (shell thickness: 0.8, 1.2, 1

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Sabale, Vidya, Hardikkumar Chaudhari, and Prafulla Sabale. "Formulation and In vitro Evaluation of Gastroretentive Floating Bioadhesive Tablets of Nizatidine using Factorial Design." Drug Delivery Letters 9, no. 3 (2019): 234–39. http://dx.doi.org/10.2174/2210303109666190221155353.

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Background: The aim of the present study was to formulate and evaluate floating bioadhesive tablets of Nizatidine which is a competitive, reversible H2-receptor antagonist. Floatingbioadhesive drug delivery system exhibiting a unique combination of floatation and bioadhesion to prolong gastric residence time was prepared. Methods: Polymers used were Hydroxy Propyl Methyl Cellulose (HPMC) K15M as matrix forming water swellable release retarding polymer and carbopol 934P as bioadhesive polymer. The gas generating agents used were sodium bicarbonate and citric acid. The prepared floating bioadhes

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D., V. Charan, C.P.Meher, and B.Pochaiah. "Design and Evaluation of Atenolol Floating Drug Delivery System." International Journal of Current Pharmaceutical Review and Research 4, no. 1 (2013): 10–26. https://doi.org/10.5281/zenodo.12690754.

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Gastroretentive floating drug delivery systems (GFDDS) of Atenolol, an antihypertensivedrug, with an oral bioavailability of only 50% (because of its poor absorption from lowergastrointestinal tract) have been designed. Polyox WSR Coagulant was used as the polymerand sodium bicarbonate as gas generating agent to reduce floating lag time. The tablets wereprepared by direct compression method.The optimized formulation containing Atenolol 50mg, Polyox WSR Coagulant 60 mg and Sodium bicarbonate 50 mg has displayed almost firstorder release kinetics with a floating lag time of only 4.7 minutes. Thi

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Sari, Shelinia Prima, Angi Nadya Bestari, and T. N. Saifullah Sulaiman. "Optimasi Formula Tablet Floating Famotidin Menggunakan Kombinasi Matriks Gum Xanthan dan Hidroksi Propil Metil Selulosa K100M." Majalah Farmaseutik 15, no. 2 (2019): 86. http://dx.doi.org/10.22146/farmaseutik.v15i2.46878.

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Famotidin adalah obat antihistamin H2 yang digunakan dalam pengobatan penyakit tukak lambung (peptic ulcer), tukak duodenal, ataupun keadaan hipersekresi yang patologis. Tablet floating famotidin dapat meningkatkan bioavailabilitas dengan mempertahankan waktu tinggal tablet dalam lambung dan mendekatkan famotidin pada tempat absorpsinya pada lambung bagian atas. Penelitian ini bertujuan untuk mengetahui komposisi optimum HPMC K100M serta gum xanthan dan pengaruh variasi keduanya terhadap sifat fisik granul dan tablet floating famotidin. Pembuatan delapan formula tablet floating famotidin mengg

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Kolli, Dr Tirumala Devi, Dr Prasada Rao Manchineni, Dr Raghavendra Kumar Gunda, and Raja Mohan M. "DESIGN, DEVELOPMENT OF CARVEDILOL FLOATING PULSATILE DRUG DELIVERY SYSTEM." Journal of Applied Pharmaceutical Sciences and Research 7, no. 1 (2024): 41–45. http://dx.doi.org/10.31069/japsr.v7i1.07.

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Objective: The current study's objective is to develop and evaluate Floating Pulsatile delivery systems (FDT) for Carvedilol. Carvedilol, Non selective α, β- receptor blocking agent. It is indicated for the treatment of moderate heart failure, Hypertension. Methods: The rapid release core tablets were formulated using various concentrations of superdisintegrants such as croscaramellose sodium, crospovidone. The optimized pulsatile release tablets were prepared by using different grades of HPMC) at different concentrations Dry coated tablets were prepared by using combination of Pulsatile layer

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Thapa, Prakash, and Seong Jeong. "Effects of Formulation and Process Variables on Gastroretentive Floating Tablets with A High-Dose Soluble Drug and Experimental Design Approach." Pharmaceutics 10, no. 3 (2018): 161. http://dx.doi.org/10.3390/pharmaceutics10030161.

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To develop sustained release gastro-retentive effervescent floating tablets (EFT), a quality-based experimental design approach was utilized during the composing of a hydrophilic matrix loaded with a high amount of a highly water-soluble model drug, metformin HCl. Effects of the amount of polyethylene oxide WSR 303 (PEO), sodium bicarbonate, and tablet compression force were used as independent variables. Various times required to release the drug, tablet tensile strength, floating lag time, tablet ejection force, and tablet porosity, were selected as the responses. Polymer screening showed th

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Patel, Dasharath M., Divyesh K. Patel, and Chhagan N. Patel. "Formulation and Evaluation of Floating Oral In Situ Gelling System of Amoxicillin." ISRN Pharmaceutics 2011 (July 28, 2011): 1–8. http://dx.doi.org/10.5402/2011/276250.

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Purpose. Effective Helicobacter pylori eradication requires delivery of the antibiotic locally in the stomach. High dose of amoxicillin (750 to 1000 mg) is difficult to incorporate in floating tablets but can easily be given in liquid dosage form. Keeping the above facts in mind, we made an attempt to develop a new floating in situ gelling system of amoxicillin with increased residence time using sodium alginate as gelling polymer to eradicate H. pylori. Methods. Floating in situ gelling formulations were prepared using sodium alginate, calcium chloride, sodium citrate, hydroxypropyl methyl ce

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Shaikh, Naumaan Naeem1* Pradnya Palekar Shanbhag2 Akshaya Aravamudhan3 Samiksha Shinde4 Sanjana Jadhav5. "Formulation And Development Of Bilayer Tablets Of Cimetidine And Ciprofloxacin HCL For Targeted Delivery." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 1478–500. https://doi.org/10.5281/zenodo.13857486.

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For researchers, creating floating tablets with the necessary buoyancy, lag time, and drug release behavior control at the target spot is an incredibly intriguing and difficult challenge. The goal of this study is to develop effervescent floating controlled release tablets containing Cimetidine and Ciprofloxacin HCl to treat peptic ulcers caused by Helicobacter pylori (H. pylori) infections. Nine formulations (F1–F9) were created. Hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M, HPMC K15M and sodium bicarbonate were used as the swelling and floating agents, respectively, during the

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S, Revathi, Raj Kumar M, Kathirvel S, et al. "FORMULATION AND EVALUATION OF HYDRODYNAMICALLY BALANCED FLOATING TABLETS OF GLYCYRRHIZA GLABRA EXTRACT." International Research Journal Of Pharmacy 13, no. 2 (2022): 9–13. http://dx.doi.org/10.7897/2230-8407.1302181.

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The aim of the study is to formulate, optimize and evaluate Glycyrrhiza glabra floating tablets using 23 optimization technique for the treatment of asthma. The extract of Glycyrrhiza glabra was prepared by subjecting crude drug to hot continuous percolation method using Soxhlet apparatus using distilled water and ethanol. The floating matrix tablets of Glycyrrhiza glabra was prepared by wet granulation technique using extract of Glycyrrhiza glabra, HPMC K15M as polymer, starch/honey as binder and sodium bicarbonate & citric acid as effervescent agents by 23 factorial design. The independe

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Kondewad, Pavan P. "Formulation and Evaluation of Gastroretentive Floating Tablets of Glipizide." International Journal for Research in Applied Science and Engineering Technology 11, no. 6 (2023): 1718–34. http://dx.doi.org/10.22214/ijraset.2023.53946.

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Abstract: The present study outlines a systematic approach for designing and development of Glipizide floating tablets to enhance the bioavailability and therapeutic efficacy of the drug. Floating tablets of Glipizide have shown controlled release thereby proper duration of action at a particular site and are designed to prolong the gastric residence time after oral administration. Different formulations were formulated by wet granulation technique using HPMC K100M (floating agent) and Xanthan gum as polymers along with sodium bicarbonate as gas generating agent. The formulations were evaluate

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Nagpal, Kajal, Fatimah Jan, Uditi Handa, et al. "ESTIMATING THE RELEASE EFFECT ON BSC-I DRUG BY USING A COMBINATION OF METHYLCELLULOSE AND EUDRAGIT® S-100 POLYMERS TO FORMULATE MINI-FLOATING TABLETS." INDIAN DRUGS 61, no. 03 (2024): 40–45. http://dx.doi.org/10.53879/id.61.03.14203.

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The purpose of the current research was to prepare a delayed-release system of mini-tablets (gastroprokinetic drug). The model drug (itopride hydrochloride) was formulated with the combination of methylcellulose (free-flowing agent) and Eudragit® S-100 (enteric coating agent) for delayed release. The research objective was to control the drug release in the stomach. The preparation of floating minitablets in three batches using different concentrations of polymers (methylcellulose in increasing order and Eudragit® S-100 remaining constant in two batches and the concentration decreased in the t

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Deshkar, Sanjeevani S., Arvind S. Pawara, and Satish V. Shirolkar. "FORMULATION AND OPTIMIZATION OF FLOATING TABLETS OF CLOPIDOGREL BISULPHATE USING DESIGN OF EXPERIMENTS." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 126. http://dx.doi.org/10.22159/ijap.2018v10i6.27873.

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Objective: The present study aimed at designing of floating matrix tablet of clopidogrel bisulphate by design of experiments.Methods: The tablets were prepared by direct compression technique using hydroxypropyl methylcellulose K15 (HPMC) as a matrix polymer and sodium bicarbonate as a gas generating agent. In order to optimize the concentration of HPMC (X1) and sodium bicarbonate (X2), a 32 full factorial design was employed. The tablet formulations were evaluated for floating lag time (Y1), floating or buoyancy time (Y2), percent water uptake, and differential scanning calorimetry (DSC) and

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Gangolu, Yohan Gajula Meghamala Darisi Saketh Chowtipalli Pushpanjali Mohammadh Rafivulla Vadapalli Rama Rao*. "Analyzing Antibacterial Drugs Floating Times for Efficiency Evaluation: A Review." International Journal of Pharmaceutical Sciences, no. 12 (December 12, 2024): 1698–711. https://doi.org/10.5281/zenodo.14416616.

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Objective: To investigate the significance of floating lag time (FLT) and total floating time (TFT) in gastro retentive drug delivery systems (GRDDS), focusing on their implications for drugs requiring sustained release or targeted delivery within the gastrointestinal tract. Methods: A review was conducted to analyze the floating characteristics of drug delivery systems, particularly emphasizing FLT and TFT. Metronidazole was selected as a case study due to its relevance in antibacterial therapy and its known properties in GRDDS. Results: Metronidazole demonstrates superior floating characteri

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Shaikh, Naumaan Naeem1* Pradnya Palekar2 Shanbhag Sanjana Jadhav3 Samiksha Shinde4 Akshaya Aravamudhan5. "Formulation And Development Of Bilayer Tablets Of Cimetidine And Sucralfate For Targeted Delivery." International Journal in Pharmaceutical Sciences 2, no. 9 (2024): 1103–22. https://doi.org/10.5281/zenodo.13824959.

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For researchers, creating floating tablets with the necessary buoyancy, lag time, and drug release behavior control at the target spot is an incredibly intriguing and difficult challenge. The goal of this study is to develop effervescent floating controlled release tablets containing Cimetidine and Sucralfate to treat peptic ulcers. Nine formulations (F1–F9) were created, which were for bi-layered tablets. Hydroxypropyl methylcellulose (HPMC) K100M, HPMC K4M, HPMC K15M and sodium bicarbonate were used as the swelling and floating agents, respectively, during the direct compression method

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Poornima, P* Abbulu K. Mukkanti K. "DESIGN AND EVALUATION OF GASTRORETENTIVE NIFEDIPINE FLOATING TABLETS IN THE TREATMENT OF HYPERTENSION." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 4178–89. https://doi.org/10.5281/zenodo.1048997.

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Gastro retentive floating tablets of Nifedipine were prepared using various grades of HPMC as a release retarding agent. Nifedipine is a dihydropyridine derivative effectively used in the management of various cardiovascular diseases in long term therapy, the biological half life is only 2 hours. The main aim of the present study is to prolong the drug release upto 24 hours. The tablets were prepared by direct compression method and the formulations were evaluated different physic chemical and dissolution studies. The formulations from each polymer F6, F10 and F20 gave better controlled drug r

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Kukati, Latha, Aisha Rahman, Aymen Fatima, Vyshak R. Menon, and SVVNSM Lakshmi. "Design, development and optimization of gastro-retentive floating in-situ gels loaded with carvedilol microspheres using response surface methodology." Acta Marisiensis - Seria Medica 71, no. 1 (2025): 60–72. https://doi.org/10.2478/amma-2025-0011.

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Abstract Aim: The goal of this study was to formulate and optimize gastro-retentive floating in-situ gel comprising optimized microspheres by Box-Behnken design. Methods: Gellan gum, k-carrageenan were used as gelling polymers and calcium carbonate as complexing and gas generating agent. For optimization X1 (concentration of k-carrageenan), X2 (concentration of calcium carbonate) and X3 (concentration of tri sodium citrate) were considered as factors and Y1 (viscosity), Y2 (floating lag time), Y3 (drug release at 8 hrs) as responses. 17 formulations obtained from the design were prepared and e

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Sreenivasa, Reddy N. Mahendra Kumar CB Ramesh A. "FORMULATION OF GASTRO RETENTIVE MATRIX TABLETS FOR ANTIHYPERTENSIVE DRUGS USING NATURAL GUMS AND LOW-DENSITY POLYMERS: EFFECT OF FORMULATION FACTORS ON IN VITRO DISSOLUTION RATES." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES o6, no. 04 (2019): 8346–60. https://doi.org/10.5281/zenodo.2650760.

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<em>The objective of the study was to develop Gastro retentive matrix tablets for antihypertensive drugs. The matrix tablets of antihypertensive drug captopril with 12 formulations coded as F1 to F12 with variant ratios of polymer were prepared in the preliminary studies by direct compression method. Hydrophilic and hydrophobic low density polymers like HPMC M15K and HPMC M4K and natural gums like Karaya gum, Xanthan gum, Pullulan gum, Gellan gum and Guar gum were used. The pre-compression parameters, and compatibility of drug with various excipient was studied using HPTLC, FTIR and DSC. The t

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Mali, Audumbar Digambar, and Ritesh Suresh Bathe. "DEVELOPMENT AND EVALUATION OF GASTRORETENTIVE FLOATING TABLETS OF A QUINAPRIL HCL BY DIRECT COMPRESSION TECHNIQUE." International Journal of Pharmacy and Pharmaceutical Sciences 9, no. 8 (2017): 35. http://dx.doi.org/10.22159/ijpps.2017v9i8.12463.

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Objective: The present study was undertaken with an objective to design, develop and evaluate gastro retentive floating tablets of an antihypertensive drug, quinapril HCl, which release the drug in a sustained manner over a period of 12 h.Methods: In this research work, we used hydrophilic polymer hydroxypropyl methylcellulose (HPMC K4M), the gas generating agent sodium bicarbonate and citric acid at different ratios for the preparation of tablets. A 32 factorial design was applied systematically; the amount of HPMC K4M (X1) and the amount of citric acid (X2) were selected as independent varia

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