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Relevant bibliographies by topics / Forced Degradation Stability studies

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Academic literature on the topic 'Forced Degradation Stability studies'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Forced Degradation Stability studies"

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Sonawane, Jayshree Kishor, Siddhi Maruti Chavan, Ishwari Prakash Narkar, et al. "A Review of Stability Indicating Methods and Forced Degradation Studies." International Journal of Research Publication and Reviews 4, no. 5 (2023): 4703–15. http://dx.doi.org/10.55248/gengpi.4.523.42372.

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Sutar, Shubhangi V., Veerendra C. Yeligar, and Shitalkumar S. Patil. "Stability Indicating Forced Degradation Studies." Research Journal of Pharmacy and Technology 12, no. 1 (2019): 429. http://dx.doi.org/10.5958/0974-360x.2019.00078.7.

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Sutar, Shubhangi V., Veerendra C. Yeligar, and Shitalkumar S. Patil. "A Review: Stability Indicating Forced Degradation Studies." Research Journal of Pharmacy and Technology 12, no. 2 (2019): 885. http://dx.doi.org/10.5958/0974-360x.2019.00152.5.

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John, Christina V., and Aruna P. Jadhav. "FORCED DEGRADATION STUDIES OF VINCAMINE BY HPTLC." INDIAN DRUGS 60, no. 11 (2023): 59–62. http://dx.doi.org/10.53879/id.60.11.14129.

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Vincamine is an alkaloid with vasodilator properties. Vinpocetine, a semi-synthetic vincamine derivative alkaloid, is used to treat cerebrovascular diseases like stroke and dementia. Being an important molecule, the current research work examines the forced degradation studies of vincamine using planar chromatography, HPTLC using stability studies parameters such as degradation by acid and base hydrolysis, oxidative stress degradation, hydrolytic induced degradation, photolytic degradation and dry heat degradation. The compound was found to be stable to oxidative stress, but significant degrad

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Y.Neelima, and Y.Kranthi Kumar*. "STABILITY INDICATING HIGH PERFORMANCE LIQUID CHROMATOGRAPHY FOR THE DETERMINATION OF LINAGLIPTIN IN BULK AND TABLET DOSAGE FORM." INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES 05, no. 07 (2018): 6512–18. https://doi.org/10.5281/zenodo.1312597.

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The Reverse Phase High Performance Liquid Chromatographic method was developed for the determination of linagliptin with its stability studies in its bulk and pharmaceutical dosage form which was precise, accurate and sensitive. The separation has been done by using the chromatographic conditions on an Inertsil ODS column (250 x 4.6 mm, 5µ particle size), the mobile phase of potassium dihydrogen phosphate buffer pH 6 and acetonitrile in the ratio 60:40 v/v, at a flow rate of 1 mL/min at an ambient temperature at a wavelength 246 nm at retention time of 3.67 minutes. The method developed

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Nageswara Rao Jakkam, Sudhakar Chintakula, and Sreenivasa Rao Battula. "Studies on forced degradation and solid state stability of tenofovir disoproxil orotate." International Journal of Research in Pharmaceutical Sciences 12, no. 4 (2021): 2485–91. http://dx.doi.org/10.26452/ijrps.v12i4.4891.

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In order to develop a stability regulatory system for drug substances and degraded products, a forced degradation study is an essential part in the design of the method. As per ICH Guidelines Q1A in 1993, it was established as an essential requirement for the regulatory system to assess the stability of drugs and their degradation products under the degradation studies by force. These analytical methods are helpful in the development of stability, indicating the method by conducting the studies on forced degradation with their mechanism of degradation. Drug products by degradation and new drug

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Bhaskar, Rajveer, Monika Ola, Vinit Agnihotri, Arjun Chavan, and Harpalsing Girase. "Current Trend in Performance of Forced Degradation Studies for Drug Substance and Drug Product’s." Journal of Drug Delivery and Therapeutics 10, no. 2-s (2020): 149–55. http://dx.doi.org/10.22270/jddt.v10i2-s.4040.

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The stability of a new drug substances and new drug products is a vital parameter which may affect purity, safety & potency. Changes in drug stability can threat patient safety by formation of toxic degradation products or deliver to lower dose than expected. Therefore it is to know the purity profile & behaviour of a drug substances under the various environmental condition. Forced Degradation studies show the chemical behavior of the molecule which in turn helps in the development of new formulation & package . Degradation study is required to the design of a regulatory compliant

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Sahil, Mansuri, Vaishnav Rajat, and Goyal Anju. "Comparison of Analytical Parameters Required for Validation Forced Degradation Studies." Pharmaceutical and Chemical Journal 8, no. 3 (2021): 97–109. https://doi.org/10.5281/zenodo.13963057.

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Force degradation studies or stress testing are commonly employed in pharmaceutical industries in order to develop a stability indicating method (SIM). In forced degradation studies, drug substance (API) or a drug product is subjected to various extremities of pH, humidity, hydrolysis and oxidation, photolytic and thermal conditions which in turn produce various degrading products known as degradants. This gives an understanding about the degradation pathways of drug substance and drug products. International Conference on Harmonization (ICH) guidelines Q1A, Q1B, Q2B, Q3A and Q3B regulate the

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Yulianita, Rini, Iyan Sopyan, and Muchtaridi Muchtaridi. "FORCED DEGRADATION STUDY OF STATINS: A REVIEW." International Journal of Applied Pharmaceutics 10, no. 6 (2018): 38. http://dx.doi.org/10.22159/ijap.2018v10i6.29086.

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Forced degradation study is the degradation of new drug substances and drug products in more severe conditions than accelerated conditions. Forced degradation study were conducted to demonstrate the specificity of stability-indicating methods, providing insight into degradation pathways and drug degradation products, assisting in the elucidation of degradation product structures, identifying degradation products that could be spontaneously generated during storage and use of drugs and to facilitate improvement in manufacturing process and formulation corresponding with accelerated stability st

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Jaya, P. Ambhore, S. Adhao Vaibhav, S. Cheke Rameshwar, R. Popat Ritesh, and J. Gandhi Shital. "Futuristic review on progress in force degradation studies and stability indicating assay method for some antiviral drugs." GSC Biological and Pharmaceutical Sciences 16, no. 1 (2021): 133–49. https://doi.org/10.5281/zenodo.5168617.

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Force degradation studies of drug substance give perceptive knowledge about the intrinsic stability of the molecule as well as possible degradants which formed during the shelf life of drug and thus, aid within the successive development of its stable formulation. A number of analytical methods with hyphenated techniques are required for the identification, determination and characterization of degraded product and impurities produce during different conditions of stress studies; Chromatographic methodology play a vital role in the field of impurity and degradation profiling .This review summa

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Dissertations / Theses on the topic "Forced Degradation Stability studies"

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Piecha, Malgorzata Trebše Polonca. "Stability and degradation studies of cholesterol-lowering statin drugs : dissertation /." Nova Gorica : [M. Piecha], 2009. http://www.p-ng.si/~vanesa/doktorati/okolje/12Piecha.pdf.

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CIAMMARUCHI, LAURA. "Studies on stability and degradation of hybrid and organic solar cells." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/203513.

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Jafar, Saad Ali. "Some nonisothermal drug stability studies using computer controlled sampling and analysis." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329123.

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CANAVESI, ROSSANA. "Chemical and metabolic stability studies of propargylamine-containing drugs." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115197.

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Tetali, Bhaskar Reddy. "Stability studies of CdTe/CdS thin film solar cells." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001135.

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Caldeira, Alisson Samuel Portes. "Estudo de degradação forçada, desenvolvimento e validação de método analítico de teor e substâncias relacionadas para avaliação da estabilidade de comprimidos de leflunomida." reponame:Repositório Institucional da FIOCRUZ, 2014. http://beta.arca.fiocruz.br/handle/icict/14590.

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Made available in DSpace on 2016-06-23T12:15:53Z (GMT). No. of bitstreams: 2 13.pdf: 3290087 bytes, checksum: c2534f744ed7289fbdbed582eaabac44 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2014<br>Made available in DSpace on 2016-07-05T22:38:02Z (GMT). No. of bitstreams: 3 13.pdf.txt: 358391 bytes, checksum: 4a43403217e6829dc1ae5000589499cf (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 13.pdf: 3290087 bytes, checksum: c2534f744ed7289fbdbed582eaabac44 (MD5) Previous issue date: 2014<br>Fundação Oswaldo

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Rhein, Bruna Thaise Rodrigues. "Desenvolvimento e validação de um método indicativo de estabilidade para o antiviral aciclovir." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-17062013-144809/.

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O aciclovir é um anti-viral usado mundialmente para o tratamento de herpes (do tipo HSV-1 e HSV-2). Acredita-se que o vírus da herpes está presente em cerca de 90% das pessoas em estado de latência. O tratamento principal em casos onde a doença se manifesta, lesões nos lábios e mucosas, é o aciclovir. No Brasil, para renovar ou fazer um novo registro de medicamento, a Agência Nacional de Vigilância Sanitária (ANVISA) exige testes que expõem o fármaco a ambientes extremos (ácido, base, luz, calor, umidade, oxidação) para gerar produtos de degradação que dependendo da concentração no produto aca

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Erra, Swetha. "Stability studies of cdte solar cells with varying amounts of cu in the back contact." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001050.

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Zong, Zhixin. "Studies on the mechanisms of solid state and solution instability of drugs." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2795.

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The overarching objective of this thesis is to demonstrate a systematic approach for addressing the instability issues associated with low limit degradants by developing quantitative degradation models that incorporate key instability determinants into predictive equations. Chlorhexidine was used as model compound in aqueous solution to demonstrate the application of the predictive models to issues of formulation design and manufacturing. Chorhexidine degrades to p-chloroaniline, a well-established toxicant, by various pH-dependent pathways. In acidic conditions, the direct formation of p-chlo

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Cuccinello, Sarah Elizabeth. "Analysis of Ahr Expression and Stability in a Recombinant Yeast Model System." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3053.

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The aryl hydrocarbon receptor (Ahr) and the aryl hydrocarbon receptor nuclear translocator (Arnt) are well characterized bHLH-PAS transcription factors shown to regulate expression of xenobiotic metabolism genes. Extensive study has shown that upon treatment with certain aromatic hydrocarbons, mammalian cells rapidly activate the Ahr signaling pathway in order to stimulate gene expression and attempt to metabolize the xenobiotic compounds. It has been shown that after DNA-binding, the Ahr but not the Arnt protein, is quickly eliminated from the nuclear compartment thereby attenuating the dose

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Books on the topic "Forced Degradation Stability studies"

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Afifi, Tamer, and Jill Jäger. Environment, Forced Migration and Social Vulnerability. Springer, 2014.

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Environment, forced migration and social vulnerability. Springer, 2010.

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Vaughn, Bruce. The Unraveling of Island Asia? Praeger, 2002. http://dx.doi.org/10.5040/9798216030911.

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This edited collection takes a primary focus on security issues in Oceania, but here the word security is expanded to include such topics as domestic Indonesian and Philippine instability, environmental degradation, the work of international crime syndicates, the generic problem of post-colonial state failure, and the always overhanging concern with China—in short all of the significant troubles roiling Island Asia today. Using this expanded notion of security and stability, the volume pulls in new anxieties about global warming, which may submerge half of the South Pacific microstates within

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McDonagh, Josephine. Literature in a Time of Migration. Oxford University Press, 2021. http://dx.doi.org/10.1093/oso/9780192895752.001.0001.

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Literature in a Time of Migration rethinks British fiction in the light of new practices of human mobility that reshaped the nineteenth-century world. Building on the growing critical engagement with globalization in literary studies, it confronts the paradox that at a time at which transnational human movement occurred globally, on a scale before unknown, British fiction appears to turn inward to tell stories of local places, in which stability and rootedness are rewarded. On the contrary, Literature in a Time of Migration reveals how literary works, from the end of the Napoleonic Wars to the

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Book chapters on the topic "Forced Degradation Stability studies"

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Hasija, Manvi, Sepideh Aboutorabian, Nausheen Rahman, and Salvador F. Ausar. "Practical Approaches to Forced Degradation Studies of Vaccines." In Vaccine Design. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3387-7_49.

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Baertschi, Steven W. "Forced Degradation and Its Relation to Real Time Drug Product Stability." In Pharmaceutical Stability Testing to Support Global Markets. Springer New York, 2009. http://dx.doi.org/10.1007/978-1-4419-0889-6_15.

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Zimmer, Markus. "Forced Degradation and Long-Term Stability Testing for Oral Drug Products: A Practical Approach." In Methods in Pharmacology and Toxicology. Springer New York, 2018. http://dx.doi.org/10.1007/978-1-4939-7686-7_4.

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Fontana, Francesco, and Giampaolo Campana. "Per- and Polyfluoroalkyl Substances: An Environmental Challenge." In Lecture Notes in Mechanical Engineering. Springer Nature Switzerland, 2025. https://doi.org/10.1007/978-3-031-77429-4_88.

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AbstractPer- and poly-fluoroalkyl substances are a group of synthetic aliphatic compounds containing one or more perfluoroalkyl moieties (CnF2n + 1-). Due to their unique surface-active properties and high chemical and thermal stability, they are used in various consumer products such as cosmetics, food packaging, furnishings, and textiles. Their use dates back to the 1940s. Despite their peculiar performances, recent scientific works investigate their sustainability and safety deriving from environmental ubiquity, persistence and bioaccumulation. Indeed, these chemicals are not metabolized in

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Mathew, Ceema. "Stability Testing and Analysis." In Analytical Methods for Drug Development. THINKPLUS PHARMA PUBLICATIONS, 2025. https://doi.org/10.69613/jzmjyx83.

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Stability testing determines how drug quality changes over time under various environmental conditions. ICH guidelines define accelerated, intermediate, and long-term testing protocols across different climatic zones and container closure systems. Forced degradation studies employ acid/base hydrolysis, oxidation, photolysis, and thermal stress to identify degradation pathways, establish degradation product profiles, and develop stability-indicating methods. These studies generate samples containing degradation products at detectable levels, creating worst-case scenarios for method development.

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Sarkar, Dr Shyamal Kumar. "CHEMICAL STABILITY OF DRUGS." In Futuristic Trends in Pharmacy & Nursing Volume 3 Book 5. Iterative International Publishers, Selfypage Developers Pvt Ltd, 2024. http://dx.doi.org/10.58532/v3bapn5ch50.

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For the process of creating new medications, stability is very essential. Any pharmaceutical product that wants to be approved or accepted must first undergo stability tests, which ensure that the product's quality, safety, and efficacy will not change over its shelf life. By providing comprehensive information about drug stability, the principle of drug degradation, force degradation studies, stability studies and their classification, factors affecting drug stability, the mechanism of drug degradation, stability testing, and various methods to increase drug stability, this article will close

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Zhou, D., W. R. Porter, and G. G. Z. Zhang. "Drug Stability and Degradation Studies." In Developing Solid Oral Dosage Forms. Elsevier, 2017. http://dx.doi.org/10.1016/b978-0-12-802447-8.00005-4.

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Zhou, Deliang, William R. Porter, and Geoff G.Z. Zhang. "Drug Stability and Degradation Studies." In Developing Solid Oral Dosage Forms. Elsevier, 2009. http://dx.doi.org/10.1016/b978-0-444-53242-8.00005-9.

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Al-Salem, S. M. "Kinetic Studies Related to Polymer Degradation and Stability." In Plastics to Energy. Elsevier, 2019. http://dx.doi.org/10.1016/b978-0-12-813140-4.00009-1.

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Maheshwari, Rahul, Pooja Todke, Neetu Soni, et al. "Stability and Degradation Studies for Drug and Drug Product." In Dosage Form Design Considerations. Elsevier, 2018. http://dx.doi.org/10.1016/b978-0-12-814423-7.00007-1.

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Conference papers on the topic "Forced Degradation Stability studies"

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Hayes, Joel R., Alan W. Szmodis, Kelly L. Anderson, and Christine A. Orme. "Effect of the Environment and Alloy Composition on the Electrochemical Behavior of Ni-Cr-Mo Alloys." In CORROSION 2004. NACE International, 2004. https://doi.org/10.5006/c2004-04697.

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Abstract Alloy 22 (UNS N06022) is the candidate material for the corrosion resistant, outer barrier of the Yucca Mountain nuclear waste containers. One of the potential corrosion degradation modes of the container is uniform or passive corrosion. Therefore it is of importance to understand the stability of the oxide film, which will control the passive corrosion rate of Alloy 22. Many variables such as temperature, composition and pH of the electrolyte, applied potential, and microstructure and composition of the base metal would determine the thickness and composition of the oxide film. The p

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Lolla, T., J. Siefert, H. Lee, et al. "Understanding the Kinetics of Sigma Phase Evolution in Super 304H using Lab Creep Tested Heats and Long-term Service Aged Components." In AM-EPRI 2024. ASM International, 2024. http://dx.doi.org/10.31399/asm.cp.am-epri-2024p0635.

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Abstract Super 304H is a new generation of advanced austenitic stainless steels that is increasingly being used in superheater/ reheater (SH/RH) sections of thermal ultra-supercritical steam power plants due to its high creep strength combined with good oxidation resistance and microstructure stability. However, recent studies have shown significant microstructural changes and associated degradation in creep performance during long-term service exposure in this alloy. Microstructure evolution during service and its effect on the long-term creep performance has not been comprehensively assessed

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Jones, Russell H., D. R. Baer, C. F. Windisch, and Raúl B. Rebak. "Corrosion Enhanced Enrichment of Sulfur and Implications for Alloy 22." In CORROSION 2006. NACE International, 2006. https://doi.org/10.5006/c2006-06621.

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Abstract The uniform corrosion rate of Alloy 22 will define the lifetime of a component such as a waste container if all other degradation modes are not operative. This represents the best-case scenario because the experimentally determined uniform corrosion rates from multi-year tests is 0.01 μm/yr or 0.1 mm in 10,000 years. This lifetime depends on the stability of the passive film over the lifetime of the container; however, this stability is unknown. One potential breakdown mechanism is corrosion-enhanced enrichment of sulfur to the surface leading to sulfur induced breakdown of the passiv

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Saganaikyzy, Samal, Tanabayeva Anar Saduakasovna, Sartayev Spatay, and Saltanat Nusupbaeva. "CONFISCATION AND SUSTAINABLE MANAGEMENT: LAW ENFORCEMENT AGENCIES AND LOCAL COMMUNITIES IN SOVIET-ERA KAZAKHSTAN (1927-1932)." In 24th SGEM International Multidisciplinary Scientific GeoConference 2024. STEF92 Technology, 2024. https://doi.org/10.5593/sgem2024v/4.2/s20.56.

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The article investigates the influence of Kazakhstan�s law enforcement agencies on local communities in the 1920s and 1930s within the context of state-driven confiscation policies and sustainable resource management, demonstrating how these agencies emerged as powerful instruments for implementing governmental directives. This era is marked by extensive political repression and profound social transformations, which enforced the forced expropriation of lands, resources, and means of production. Such interventions disrupted established economic practices and social structures, leading to subst

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Aswad, Muhammad, Umbi Safariah, and Risfah Yulianty. "Forced degradation studies on the piperine-based benzene sulfonylamidine: The effect of acid, base, and peroxide on its stability." In THE PROCEEDINGS OF THE 4TH EPI INTERNATIONAL CONFERENCE ON SCIENCE AND ENGINEERING (EICSE) 2020. AIP Publishing, 2022. http://dx.doi.org/10.1063/5.0094726.

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Fears, R., H. Ferres, and R. Standring. "THE PROTECTIVE EFFECT OF ACYLATI0N ON THE STABILITY OF EMINASE (APSAC) IN HUMAN PLASMA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1642999.

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Clinical and animal studies indicate that APSAC (anisoylated plasminogen.streptokinase activator complex, Eminase) circulates longer in the bloodstream in an active form than the other thrombolytics. In the present studies in vitro u/e have found that functional activity of APSAC is maintained in human plasma longer than that of SK.plasmin(ogen): the relative stability half-lives are similar to the plasma clearance haif-lives in patients. Some of the loss of activity of SK at early times can be attributed to neutralisation by inhibitors. Thus, the survival of fibrinolytically-active SK was pro

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Jindal, Keshav, Saahil Arora, and Manish Goswami. "Forced degradation studies of thiocolchicoside." In THE FOURTH SCIENTIFIC CONFERENCE FOR ELECTRICAL ENGINEERING TECHNIQUES RESEARCH (EETR2022). AIP Publishing, 2023. http://dx.doi.org/10.1063/5.0163084.

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Pise, Nikita Pravin, Arati Prabhu, and Radhika Raheja. "Forced Degradation Studies on Agents of Therapeutic Interest." In ECMC 2022. MDPI, 2022. http://dx.doi.org/10.3390/ecmc2022-13233.

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Kulkarni, Vaibhav, and Kiran Sonawane. "Forced degradation studies on Naratriptan HCL by High Performance Liquid Chromatography." In The 21st International Electronic Conference on Synthetic Organic Chemistry. MDPI, 2017. http://dx.doi.org/10.3390/ecsoc-21-04808.

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Iorio, V. S., F. Cracolici, E. Previde Massara, A. Consonni, F. Parrozza, and A. Lainati. "Technical Insights into the Compatibility of Salt-Saturated Cement for Underground Storage in Salt Caverns." In SPE Europe Energy Conference and Exhibition. SPE, 2024. http://dx.doi.org/10.2118/220096-ms.

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Abstract The need for a sustainable and decarbonized energy system has led to a renewed interest in Underground Hydrogen Storage (UHS). These caverns, formed by solution mining of underground salt deposits, offer large storage volumes and high structural integrity. Furthermore, salt caverns exhibit containment properties, with their impermeable salt formations ensuring long-term storage without significant degradation of the hydrogen. This paper investigates the compatibility of salt-saturated cement for Underground Hydrogen Storage in salt caverns. The primary aim is to scrutinize how hydroge

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Reports on the topic "Forced Degradation Stability studies"

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Stern, David, and Gadi Schuster. Manipulation of Gene Expression in the Chloroplast. United States Department of Agriculture, 2000. http://dx.doi.org/10.32747/2000.7575289.bard.

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The steady-state level of a given mRNA is determined by its rates of transcription and degradation. The stabilities of chloroplast mRNAs vary during plant development, in part regulating gene expression. Furthermore, the fitness of the organelle depends on its ability to destroy non-functional transcripts. In addition, there is a resurgent interest by the biotechnology community in chloroplast transformation due to the public concerns over pollen transmission of introduced traits or foreign proteins. Therefore, studies into basic gene expression mechanisms in the chloroplast will open the door

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Deschamps, Robert, and Henschel. PR-420-133721-R01 Comparison of Radar Satellite Methods for Observation of Stability. Pipeline Research Council International, Inc. (PRCI), 2015. http://dx.doi.org/10.55274/r0010840.

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This report discusses the use of Synthetic Aperture Radar (SAR) satellites for monitoring above ground pipelines and buried pipeline Rights-Of-Way (ROWs) using Interferometric Synthetic Aperture Radar (InSAR) techniques. The main thrust of the research was to evaluate the suitability of above-ground pipeline support members as InSAR measurement points, and to adapt existing techniques to allow for precise monitoring of jacking and subsidence caused by permafrost degradation and dynamics. The study site at Prudhoe Bay, Alaska includes more than 60,000 horizontal pipeline supports. The known loc

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Szałańska, Justyna, Justyna Gać, Ewa Jastrzębska, et al. Country report: Poland. Welcoming spaces in relation to social wellbeing, economic viability and political stability in shrinking regions. Welcoming Spaces Consortium, 2022. http://dx.doi.org/10.33119/welcoming_spaces_2022.

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This report aims to present findings of the research conducted in Poland within the Work Package 1 of the Welcoming Spaces project, namely “Welcoming spaces” in relation to economic viability, social wellbeing and political stability in shrinking regions. The main aim of the mentioned research was to examine how welcoming initiatives are organised and implemented in the selected shrinking localities in Poland. In particular, the creation of welcoming initiatives concerning social wellbeing, economic viability and political stability was assessed. To accomplish this objective, five localities w

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Carrigee, Lyndsay, Carina Jung, Matthew Carr, and Karl Indest. Bacterial remediation of microsystin-HAB toxins utilizing microcystinase (MlrA). Engineer Research and Development Center (U.S.), 2025. https://doi.org/10.21079/11681/49673.

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Microcystins are a class of hepatotoxins produced by some harmful algal bloom–associated cyanobacteria and are the most reported toxins in freshwaters. Their cyclic structure makes them resistant to conventional methods used in water treatment operations (boiling, chlorination, and UV treatment). Some bacteria can naturally degrade microcystins via the mlrABCD cluster, a pathway initiated by the primary enzyme microcystinase (MlrA). MlrA linearizes the cyclic microcystin, greatly reducing its toxicity. Protein fusion was employed to produce a recombinant MlrA enzyme fused to maltose-binding pr

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Nagabhatla, Nidhi, Panthea Pouramin, Rupal Brahmbhatt, et al. Migration and Water: A Global Overview. United Nations University Institute for Water, Environment and Health, 2020. http://dx.doi.org/10.53328/lkzr3535.

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Global migration has been increasing since the 1990s. People are forced to leave their homes in search of safety, a better livelihood, or for more economic opportunities. Environmental drivers of migration, such as land degradation, water pollution, or changing climate, are acting as stronger phenomena with time. As millions of people are exposed to multiple water crises, daily needs related to water quality, lack of provisioning, excess or shortage of water become vital for survival as well for livelihood support. In turn, the crisis can transform into conflict and act as a trigger for migrat

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Epel, Bernard L., Roger N. Beachy, A. Katz, et al. Isolation and Characterization of Plasmodesmata Components by Association with Tobacco Mosaic Virus Movement Proteins Fused with the Green Fluorescent Protein from Aequorea victoria. United States Department of Agriculture, 1999. http://dx.doi.org/10.32747/1999.7573996.bard.

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The coordination and regulation of growth and development in multicellular organisms is dependent, in part, on the controlled short and long-distance transport of signaling molecule: In plants, symplastic communication is provided by trans-wall co-axial membranous tunnels termed plasmodesmata (Pd). Plant viruses spread cell-to-cell by altering Pd. This movement scenario necessitates a targeting mechanism that delivers the virus to a Pd and a transport mechanism to move the virion or viral nucleic acid through the Pd channel. The identity of host proteins with which MP interacts, the mechanism

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Jouini, Meriem, and Jennie Barron. Living labs as collaborative action for soil health: examples in Sweden for agriculture, forestry and urban land. Department of Soil and Environment, Swedish University of Agricultural Sciences, 2025. https://doi.org/10.54612/a.137159daj3.

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Soil degradation remains a critical challenge across Europe, threatening environmental sustainability, agricultural productivity, and human well-being. In response, the European Commission’s Mission Soil initiative aims to establish 100 Living Labs (LL) and Lighthouses by 2030 to promote innovative and sustainable soil management. Living Labs are defined by three core principles: co-creation, user-centered innovation, and real-world setting, enabling diverse stakeholders to jointly develop, test, and scale solutions that address soil-related challenges and soil health. This report explores how

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Davies, Will. Improving the engagement of UK armed forces overseas. Royal Institute of International Affairs, 2022. http://dx.doi.org/10.55317/9781784135010.

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The UK government’s Integrated Review of security, defence, development and foreign policy, published in March 2021 alongside a supporting defence command paper, set a new course for UK national security and highlighted opportunities for an innovative approach to international engagement activity. The Integrated Review focused principally on the state threats posed by China’s increasing power and by competitors – including Russia – armed with nuclear, conventional and hybrid capabilities. It also stressed the continuing risks to global security and resilience due to conflict and instability in

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