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Dissertations / Theses on the topic 'Forced Degradation Stability studies'

Author: Grafiati

Published: 3 June 2025

Last updated: 1 August 2025

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1

Piecha, Malgorzata Trebše Polonca. "Stability and degradation studies of cholesterol-lowering statin drugs : dissertation /." Nova Gorica : [M. Piecha], 2009. http://www.p-ng.si/~vanesa/doktorati/okolje/12Piecha.pdf.

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2

CIAMMARUCHI, LAURA. "Studies on stability and degradation of hybrid and organic solar cells." Doctoral thesis, Università degli Studi di Roma "Tor Vergata", 2013. http://hdl.handle.net/2108/203513.

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3

Jafar, Saad Ali. "Some nonisothermal drug stability studies using computer controlled sampling and analysis." Thesis, University of Manchester, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.329123.

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4

CANAVESI, ROSSANA. "Chemical and metabolic stability studies of propargylamine-containing drugs." Doctoral thesis, Università del Piemonte Orientale, 2016. http://hdl.handle.net/11579/115197.

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5

Tetali, Bhaskar Reddy. "Stability studies of CdTe/CdS thin film solar cells." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001135.

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6

Caldeira, Alisson Samuel Portes. "Estudo de degradação forçada, desenvolvimento e validação de método analítico de teor e substâncias relacionadas para avaliação da estabilidade de comprimidos de leflunomida." reponame:Repositório Institucional da FIOCRUZ, 2014. http://beta.arca.fiocruz.br/handle/icict/14590.

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Made available in DSpace on 2016-06-23T12:15:53Z (GMT). No. of bitstreams: 2 13.pdf: 3290087 bytes, checksum: c2534f744ed7289fbdbed582eaabac44 (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) Previous issue date: 2014<br>Made available in DSpace on 2016-07-05T22:38:02Z (GMT). No. of bitstreams: 3 13.pdf.txt: 358391 bytes, checksum: 4a43403217e6829dc1ae5000589499cf (MD5) license.txt: 1748 bytes, checksum: 8a4605be74aa9ea9d79846c1fba20a33 (MD5) 13.pdf: 3290087 bytes, checksum: c2534f744ed7289fbdbed582eaabac44 (MD5) Previous issue date: 2014<br>Fundação Oswaldo

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7

Rhein, Bruna Thaise Rodrigues. "Desenvolvimento e validação de um método indicativo de estabilidade para o antiviral aciclovir." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/9/9141/tde-17062013-144809/.

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O aciclovir é um anti-viral usado mundialmente para o tratamento de herpes (do tipo HSV-1 e HSV-2). Acredita-se que o vírus da herpes está presente em cerca de 90% das pessoas em estado de latência. O tratamento principal em casos onde a doença se manifesta, lesões nos lábios e mucosas, é o aciclovir. No Brasil, para renovar ou fazer um novo registro de medicamento, a Agência Nacional de Vigilância Sanitária (ANVISA) exige testes que expõem o fármaco a ambientes extremos (ácido, base, luz, calor, umidade, oxidação) para gerar produtos de degradação que dependendo da concentração no produto aca

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8

Erra, Swetha. "Stability studies of cdte solar cells with varying amounts of cu in the back contact." [Tampa, Fla.] : University of South Florida, 2005. http://purl.fcla.edu/fcla/etd/SFE0001050.

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9

Zong, Zhixin. "Studies on the mechanisms of solid state and solution instability of drugs." Diss., University of Iowa, 2011. https://ir.uiowa.edu/etd/2795.

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The overarching objective of this thesis is to demonstrate a systematic approach for addressing the instability issues associated with low limit degradants by developing quantitative degradation models that incorporate key instability determinants into predictive equations. Chlorhexidine was used as model compound in aqueous solution to demonstrate the application of the predictive models to issues of formulation design and manufacturing. Chorhexidine degrades to p-chloroaniline, a well-established toxicant, by various pH-dependent pathways. In acidic conditions, the direct formation of p-chlo

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10

Cuccinello, Sarah Elizabeth. "Analysis of Ahr Expression and Stability in a Recombinant Yeast Model System." Scholar Commons, 2011. http://scholarcommons.usf.edu/etd/3053.

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The aryl hydrocarbon receptor (Ahr) and the aryl hydrocarbon receptor nuclear translocator (Arnt) are well characterized bHLH-PAS transcription factors shown to regulate expression of xenobiotic metabolism genes. Extensive study has shown that upon treatment with certain aromatic hydrocarbons, mammalian cells rapidly activate the Ahr signaling pathway in order to stimulate gene expression and attempt to metabolize the xenobiotic compounds. It has been shown that after DNA-binding, the Ahr but not the Arnt protein, is quickly eliminated from the nuclear compartment thereby attenuating the dose

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11

Souza, Aline de. "Desenvolvimento de metodologias indicativas de estabilidade para medicamentos utilizados como diuréticos." Universidade de São Paulo, 2015. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-15122015-084128/.

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Os diuréticos aumentam o fluxo urinário e a excreção de sódio e são utilizados para ajustar o volume e/ou a composição dos líquidos corporais em uma variedade de situações clínicas. A furosemida é um agente diurético potente que induz uma poderosa diurese. É utilizada no tratamento de edema associado com o coração e doenças renais. Nesta pesquisa objetivou-se desenvolver métodos indicativos de estabilidade para a furosemida, por eletroforese capilar em solução livre (FSCE) e cromatografia liquida de alta eficiência (CLAE). O método por FSCE utilizou um capilar de sílica fundida com comprimento

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12

Galdos, Angel Arturo Gaona. "Desenvolvimento de metodologias indicativas de estabilidade para medicamentos que atuam no diabetes mellitus tipo II." Universidade de São Paulo, 2012. http://www.teses.usp.br/teses/disponiveis/9/9139/tde-04042013-092152/.

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O diabetes mellitus (DM) é uma síndrome na qual o metabolismo de hidratos de carbono, gorduras e proteínas está alterado, por falta de secreção de insulina ou por diminuição da sensibilidade tissular a este hormônio. O DM pode ser do tipo I, também denominado diabetes mellitus insulinodependente (DMID), caracterizado pela falta de secreção da insulina, e do tipo II, também denominado diabetes mellitus não insulinodependente (DMNID), caracterizado pela menor sensibilidade dos tecidos efetores às ações metabólicas da insulina. Embora ainda não haja cura definitiva, há vários tratamentos disponív

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13

Fu, Wei. "Regulation of FOXO stability and activity by MDM2 E3 ligase." [Tampa, Fla] : University of South Florida, 2007. http://purl.fcla.edu/usf/dc/et/SFE0002222.

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14

Breier, Ana Rita. "Fexofenadina : validação de métodos analíticos e estudo de fotoestabilidade." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/10354.

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Este trabalho objetivou o desenvolvimento e validação de métodos analíticos para determinação de fexofenadina em cápsulas e comprimidos revestidos e o estudo de fotoestabilidade do fármaco. A determinação da faixa de fusão e a espectrofotometria no infravermelho permitiram identificar fexofenadina substância química de referência. Os métodos por cromatografia em camada delgada, espectrofotometria no ultravioleta (UV), cromatografia líquida de alta eficiência (CLAE) e eletroforese capilar (EC) foram utilizados para análise qualitativa do fármaco nas formas farmacêuticas. A determinação quantita

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15

Vaucher, Lauren Rosa Crossetti. "Telitromicina : métodos de análise, ensaio de dissolução e estudo da estabilidade." reponame:Biblioteca Digital de Teses e Dissertações da UFRGS, 2007. http://hdl.handle.net/10183/11299.

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A telitromicina é o primeiro representante de uma nova família de antibióticos os cetolídeos. Os cetolídeos são derivados semi-sintéticos dos macrolídeos. No Brasil encontra-se disponível na forma de comprimidos revestidos com o nome comercial de Ketek®. Este trabalho objetivou o desenvolvimento e validação de métodos analíticos para determinação da telitromicina em comprimidos revestidos, desenvolvimento e validação do ensaio de dissolução e estudo da estabilidade do fármaco. A determinação da faixa de fusão e a espectrofotometria no infravermelho permitiram identificar a telitromicina substâ

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16

Llobet, Maria Teresa Pardal Porto. "Forced degradation study of fencarol 10 mg/ml solution for injection using UPLC method." Master's thesis, 2014. http://hdl.handle.net/10451/38739.

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Trabalho Final de Mestrado Integrado, Ciências Farmacêuticas, Universidade de Lisboa, Faculdade de Farmácia, 2014<br>Force degradation study is an important tool in pharmaceutical process in order to develop stability-‐indicating methods that lead to quality data and to understand degradation pathways of drug substances and drug product. In this study, Fencarol 10mg/mL solution for injection was submitted to different conditions to determine the effect of excipients present in the formulation in assessing drug product stability and to develop and demonstrate the specificity of stability-indi

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17

Li, Mengqing. "Stability studies of intravenous cyclosporine preparations stored in non-PVC containers." Thèse, 2012. http://hdl.handle.net/1866/9073.

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Dans cette étude, la stabilité de préparations intraveineuses de cyclosporine (0.2 et 2.5 mg/mL dans NaCl 0.9% ou dextrose 5%) entreposées dans des seringues de polypropylène, des sacs de polypropylène-polyoléfine et des sacs de vinyle acétate d’éthylène a été évaluée. Une méthode HPLC indicatrice de la stabilité à base de méthanol a été développée et validée suite a des études de dégradation forcée. Les solutions évaluées ont été préparées de façon aseptique, puis entreposées à 25°C. La stabilité chimique a été évaluée par HPLC et la stabilité physique a été évaluée par inspection visuelle et

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18

Liu, Te-Hsi, and 劉德禧. "Studies on Stability and Degradation Kinetics of Submicron- and Nano-encapsulated Lycopene." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/54650011158178049744.

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碩士<br>輔仁大學<br>食品科學系<br>95<br>Lycopene, one of the major carotenoids, is naturally present in an all-trans form in vegetables and fruits. With a long chain conjugated carbon-carbon double bonds, lycopene possesses antioxidative and free-radical scavenging abilities, and reduces the risk of cancers. Its biological activity may decrease when lycopene is thermally isomerized or oxidatively degraded under light exposure. Therefore, nano-encapsulated lycopene (NPL) was developed to protect it from environmental damage. The objectives of this study are to evaluate the stability of nanocapsules（NPs）an

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19

Máchalová, Jitka. "Studium nucené degradace canagliflozinu s využitím HPLC." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-415928.

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In this work a method for determination of canagliflozin and its degradation products by HPLC with UV and MS detector was developed. The developed method was used to study the forced degradation of canagliflozin and to investigate the major degradation products resulting from exposure of canagliflozin to oxidative stress. Canagliflozin is a phenolic glycoside derivative and a glucose-sodium transporter 2 inhibitor that stimulates urinary glucose excretion by suppressing glucose reabsorption from the proximal tubule in the kidneys. Canagliflozin is used to control blood glucose levels in patien

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20

Tsou, Pei-Chung, and 鄒佩君. "Studies on stability and oxidative degradation kinetics of simultaneous nano-encapsulated fish oil and quercetin." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/72928957414624675611.

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碩士<br>輔仁大學<br>食品科學系<br>96<br>Fish oils are rich in ω-3 polyunsaturated fatty acids (ω-3 PUFA). Both especially eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are predominant in ω-3 PUFA and possess many biological activities. However, their food application is limited because of their high susceptibility to oxidation. The objectives of this study are to develop nanoparticles with simultaneous nano-encapsulation of fish oil and quercetin and to evaluate the thermal stability and the oxidative degradation kinetics. Dynamic light scattering analysis showed that the average particle

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