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Relevant bibliographies by topics / Formalin-induced paw-licking test

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Journal articles

Academic literature on the topic 'Formalin-induced paw-licking test'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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Journal articles on the topic "Formalin-induced paw-licking test"

1

Bseiso, Yousra, Abdelrahim Alqudah, Esam Qnais, Mohammed Wedyan, Kayed Abu-Safieh та Omar Gammoh. "2ʹ,3,3,5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1,3ʹ-bipyrazole exerts antinociceptive effect using various nociception models". Pharmacia 70, № 3 (2023): 509–17. http://dx.doi.org/10.3897/pharmacia.70.e104828.

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Background: 2ʹ,3,3,5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1,3ʹ-bipyrazole (TMNB) is a novel bipyrazole compound that exhibited antidiabetic and anti-inflammatory properties. However, its analgesic effect has not been investigated. This study aimed to assess the antinociceptive activity of TMNB using different nociception mouse models. Methods: TMNB doses (50, 100, 150, and 200 µg/kg) were assessed in mice using the acetic acid-induced writhing test, hot plate test, and formalin-induced paw licking assay. The effects were compared to those of mice treated with acetylsalicylic acid or morphine in the prese

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2

Bseiso, Yousra, Abdelrahim Alqudah, Esam Qnais, Mohammed Wedyan, Kayed Abu-Safieh та Omar Gammoh. "2ʹ,3,3,5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1,3ʹ-bipyrazole exerts antinociceptive effect using various nociception models". Pharmacia 70, № (3) (2023): 509–17. https://doi.org/10.3897/pharmacia.70.e104828.

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Background: 2ʹ,3,3,5ʹ-Tetramethyl-4ʹ-nitro-2ʹH-1,3ʹ-bipyrazole (TMNB) is a novel bipyrazole compound that exhibited antidiabetic and anti-inflammatory properties. However, its analgesic effect has not been investigated. This study aimed to assess the antinociceptive activity of TMNB using different nociception mouse models. Methods: TMNB doses (50, 100, 150, and 200 µg/kg) were assessed in mice using the acetic acid-induced writhing test, hot plate test, and formalin-induced paw licking assay. The effects were compared to those of mice treated with acetylsalicylic acid or morphine in the prese

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3

Al-Bzour, Manal H., Yousra Bsieso, Omar Gammoh, et al. "Exploring the antinociceptive potential of homoeriodictyol in nociception models." Journal of Pharmacy & Pharmacognosy Research 12, no. 4 (2024): 615–23. http://dx.doi.org/10.56499/jppres23.1878_12.4.615.

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Context: Homoeriodictyol is a flavonoid with known antioxidant, anti-inflammatory, and anti-tumor properties found in various plants. However, its potential analgesic effects have not been explored. Aims: To investigate the pain-relieving properties of homoeriodictyol using different mouse models of nociception. Methods: Various doses of homoeriodictyol (50, 100, 150, and 200 µg/kg) were administered to mice and evaluated using the acetic acid-induced writhing test, the hot plate test, and the formalin-induced paw licking assay. These effects were compared with those of mice treated with acety

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4

Ayumi, Rasyidah Ryta, Wan Mastura Shaik Mossadeq, Zainul Amiruddin Zakaria, et al. "Antinociceptive Activity of Asiaticoside in Mouse Models of Induced Nociception." Planta Medica 86, no. 08 (2020): 548–55. http://dx.doi.org/10.1055/a-1144-3663.

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AbstractThe antinociceptive property of Centella asiatica extracts is known but the analgesic activity of its bioactive constituent asiaticoside has not been reported. We evaluated the antinociceptive activity of orally (p. o.) administered asiaticoside (1, 3, 5, and 10 mg/kg) in mice using the 0.6% acetic acid-induced writhing test, the 2.5% formalin-induced paw licking test, and the hot plate test. The capsaicin- and glutamate-induced paw licking tests were employed to evaluate the involvement of the vanilloid and glutamatergic systems, respectively. Asiaticoside (3, 5, and 10 mg/kg, p. o.)

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5

Borges, Rodrigo, Marcus Vinícius Mariano Nascimento, Adryano Augustto Valladão de Carvalho, et al. "Antinociceptive and Anti-Inflammatory Activities of the Ethanolic Extract fromSynadenium umbellatumPax. (Euphorbiaceae) Leaves and Its Fractions." Evidence-Based Complementary and Alternative Medicine 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/715650.

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Synadenium umbellatumPax., popularly known in Brazil as “cola-nota,” “avelós,” “cancerola,” and “milagrosa”, is a plant species used in folk medicine for the treatment of inflammation, pain, and several diseases. This study aimed to investigate the antinociceptive and anti-inflammatory activities of the ethanolic extract fromSynadenium umbellatumPax. leaves (EES) and its hexane (HF), chloroform (CF), and methanol/water (MF) fractions using the acetic acid-induced abdominal writhing test, formalin-induced paw licking test, tail flick test, croton oil-induced ear edema test, and carrageenan-indu

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6

Liao, Chi-Ren, Chun-Pin Kao, Wen-Huang Peng, Yuan-Shiun Chang, Shang-Chih Lai, and Yu-Ling Ho. "Analgesic and Anti-Inflammatory Activities of Methanol Extract ofFicus pumilaL. in Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–9. http://dx.doi.org/10.1155/2012/340141.

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This study investigated possible analgesic and anti-inflammatory mechanisms of the methanol extract ofFicus pumila(FPMeOH). Analgesic effects were evaluated in two models including acetic acid-induced writhing response and formalin-induced paw licking. The results showedFPMeOHdecreased writhing response in the acetic acid assay and licking time in the formalin test. The anti-inflammatory effect was evaluated by λ-carrageenan-induced mouse paw edema and histopathological analyses.FPMeOHsignificantly decreased the volume of paw edema induced by λ-carrageenan. Histopathologically,FPMeOHabated the

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7

Doncheva, Nina D., Anita St Mihaylova, and Damianka P. Getova. "Antinociceptive and anti-inflammatory effects of Rhodiola Rosea L. extract in rats." Folia Medica 55, no. 3-4 (2013): 70–75. http://dx.doi.org/10.2478/folmed-2013-0030.

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ABSTRACT BACKGROUND: Rhodiola rosea (golden root) is a unique phytoadaptagen with immunomodulatory, antioxidant, anti-inflammatory and antinociceptive activity. AIM: The aim of this study was to evaluate the antinociceptive and anti-inflammatory effects of the alcohol/water extract of Rhodiola rosea roots in rats. MATERIALS AND METHODS: Thirty male Wistar rats were used in the study. They were divided in 3 groups (n = 10), treated respectively with saline (controls), Rhodiola rosea extract 50 mg/kg bw and 100 mg/kg bw orally. The antinociceptive effect was evaluated using the hot-plate test, R

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8

Hossain, Emran, Abdullah Aziz, Nusrat Jahan Vabna, et al. "Phytochemical Screening and Pharmacological Evaluation of the Methanolic Extract of Cissus Elongata Roxb. Leaves." Jordan Journal of Pharmaceutical Sciences 15, no. 4 (2022): 449–60. http://dx.doi.org/10.35516/jjps.v15i4.670.

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This study evaluates the pharmacological activity of the methanolic extract of Cissus elongata Roxb. leaves. Dried leaves of C. elongata were extracted with methanol. The crude extract was then tested to identify the presence of different phytoconstituents. To evaluate the pharmacological effects of this plant- analgesic, anti-diarrheal, anti-inflammatory and antipyretic, tests were conducted using animal models. Analgesic activity was evaluated by an acetic acid-induced writhing test, formalin-induced paw-licking test paw-licking immersion test. Castor oil-induced anti-diarrheal test was perf

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9

Osukoya, O. A., A. Cheke, O. B. Adewale, J. O. Awe, and O. Olasehinde. "In vitro Antioxidant and Analgesic Properties of Methanolic Extracts of the Fruits of Xylopia aethiopica on Formalin-Induced Nociception." Nigerian Journal of Environment and Health 2, no. 2019 (2019): 57–63. https://doi.org/10.5281/zenodo.14656309.

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Xylopia aethiopica, negro pepper, is commonly used in traditional medicine to treat different kinds of diseases and infections. Methanolic extract of the fruit of Xylopia aethiopica was evaluated for its antioxidant and analgesic properties. Qualitative and quantitative phytochemical screening of the extract was done according to standard procedures. Antioxidant potential was investigated using 2,2-diphenyl-1-picryl hydrazyl (DPPH) scavenging activity. Analgesic activity was carried out using formalin induced paw licking test in albino rats at 100, 200 and 400 mg extract per kg

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10

Chou, Shen-Chieh, Yung-Jia Chiu, Chao-Jung Chen, et al. "Analgesic and Anti-Inflammatory Activities of the Ethanolic Extract ofArtemisia morrisonensisHayata in Mice." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–11. http://dx.doi.org/10.1155/2012/138954.

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The aim of this study was to investigate the possible analgesic and anti-inflammatory mechanisms of the ethanolic extract ofA. morrisonensisHayata (AMEtOH). Two models were employed for evaluation of the analgesic effects: acetic acid-induced writhing response and formalin-induced paw licking. The results demonstrated thatAMEtOHdecreased writhing response for both the acetic acid assay and the licking time in the formalin test. The anti-inflammatory effect was evaluated by paw edema of mice induced byλ-carrageenan.AMEtOHsignificantly decreased induced paw edema three to four hours afterλ-carra

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