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Relevant bibliographies by topics / Functionalized oligonucleotides

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Academic literature on the topic 'Functionalized oligonucleotides'

Author: Grafiati

Published: 4 June 2021

Last updated: 1 February 2022

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Journal articles on the topic "Functionalized oligonucleotides"

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Pérez-Rentero, Sónia, Alvaro Somoza, Santiago Grijalvo, et al. "Biophysical and RNA Interference Inhibitory Properties of Oligonucleotides Carrying Tetrathiafulvalene Groups at Terminal Positions." Journal of Chemistry 2013 (2013): 1–11. http://dx.doi.org/10.1155/2013/650610.

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Oligonucleotide conjugates carrying a single functionalized tetrathiafulvalene (TTF) unit linked through a threoninol molecule to the 3′ or 5′ ends were synthesized together with their complementary oligonucleotides carrying a TTF, pyrene, or pentafluorophenyl group. TTF-oligonucleotide conjugates formed duplexes with higher thermal stability than the corresponding unmodified oligonucleotides and pyrene- and pentafluorophenyl-modified oligonucleotides. TTF-modified oligonucleotides are able to bind to citrate-stabilized gold nanoparticles (AuNPs) and produce stable gold AuNPs functionalized wi

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Kosiova, Ivana, and Pavol Kois. "Synthesis of Novel Coumarin-Based Fluorescent Probes." Collection of Czechoslovak Chemical Communications 72, no. 8 (2007): 996–1004. http://dx.doi.org/10.1135/cccc20070996.

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We report on synthesis of new fluorescent probes suitable for site-specific incorporation into oligonucleotides. Coumarin derivatives were used as sensitive fluorescent labels and were attached to glycerol unit by two types of linkers as potential building blocks for oligonucleotide synthesis. Spectral characteristics of the functionalized coumarin building blocks were measured.

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Parelius Jonášová, Eleonóra, and Bjørn Torger Stokke. "Morpholino Target Molecular Properties Affect the Swelling Process of Oligomorpholino-Functionalized Responsive Hydrogels." Polymers 12, no. 2 (2020): 268. http://dx.doi.org/10.3390/polym12020268.

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Responsive hydrogels featuring DNA as a functional unit are attracting increasing interest due to combination of versatility and numerous applications. The possibility to use nucleic acid analogues opens for further customization of the hydrogels. In the present work, the commonly employed DNA oligonucleotides in DNA-co-acrylamide responsive hydrogels are replaced by Morpholino oligonucleotides. The uncharged backbone of this nucleic acid analogue makes it less susceptible to possible enzymatic degradation. In this work we address fundamental issues related to key processes in the hydrogel res

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SHARMA, GAURAV, ZHI-GANG SHE, DAVID T. VALENTA, WILLIAM B. STALLCUP, and JEFFREY W. SMITH. "SCAVENGER RECEPTOR-MEDIATED TARGETING OF MACROPHAGE FOAM CELLS IN ATHEROSCLEROTIC PLAQUE USING OLIGONUCLEOTIDE-FUNCTIONALIZED NANOPARTICLES." Nano LIFE 01, no. 03n04 (2010): 207–14. http://dx.doi.org/10.1142/s1793984410000183.

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Macrophage foam cells are key components of atherosclerotic plaque and play an important role in the progression of atherosclerosis leading to plaque rupture and thrombosis. Foam cells are emerging as attractive targets for therapeutic intervention and imaging the progression of disease. Therefore, designing nanoparticles (NPs) targeted to macrophage foam cells in plaque is of considerable therapeutic significance. Here we report the construction of an oligonucleotide-functionalized NP system with high affinity for foam cells. Nanoparticles functionalized with a 23-mer poly-Guanine (polyG) oli

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M. Varizhuk, Anna, Svetlana V. Kochetkova, Alexander U. Fedotov, Natalia A. Kolganova, Edward N. Timofeev, and Vladimir L. Florentiev. "Amino-Functionalized Oligonucleotides with Peptide Internucleotide Linkages." Letters in Organic Chemistry 9, no. 2 (2012): 106–13. http://dx.doi.org/10.2174/157017812800221799.

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D'Agata, Roberta, Pasquale Palladino, and Giuseppe Spoto. "Streptavidin-coated gold nanoparticles: critical role of oligonucleotides on stability and fractal aggregation." Beilstein Journal of Nanotechnology 8 (January 2, 2017): 1–11. http://dx.doi.org/10.3762/bjnano.8.1.

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Gold nanoparticles (AuNPs) exhibit unique properties that can be modulated through a tailored surface functionalization, enabling their targeted use in biochemical sensing and medical diagnostics. In particular, streptavidin-modified AuNPs are increasingly used for biosensing purposes. We report here a study of AuNPs surface-functionalized with streptavidin-biotinylated oligonucleotide, focussing on the role played by the oligonucleotide probes in the stabilization/destabilization of the functionalized nanoparticle dispersion. The behaviour of the modified AuNP dispersion as a consequence of t

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Kaura, Mamta, and Patrick J. Hrdlicka. "Locked nucleic acid (LNA) induced effect on the hybridization and fluorescence properties of oligodeoxyribonucleotides modified with nucleobase-functionalized DNA monomers." Organic & Biomolecular Chemistry 13, no. 26 (2015): 7236–47. http://dx.doi.org/10.1039/c5ob00860c.

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Mixmer oligonucleotides modified with LNA and C5-pyrene-functionalized DNA monomers are shown to display interesting fluorescence properties for the discrimination of single nucleotide polymorphisms (SNPs).

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Alexaki, Konstantina, Davide Giust, Maria-Eleni Kyriazi, et al. "A DNA sensor based on upconversion nanoparticles and two-dimensional dichalcogenide materials." Frontiers of Chemical Science and Engineering 15, no. 4 (2021): 935–43. http://dx.doi.org/10.1007/s11705-020-2023-9.

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AbstractWe demonstrate the fabrication of a new DNA sensor that is based on the optical interactions occurring between oligonucleotide-coated NaYF4:Yb3+;Er3+ upconversion nanoparticles and the two-dimensional dichalcogenide materials, MoS2 and WS2. Monodisperse upconversion nanoparticles were functionalized with single-stranded DNA endowing the nanoparticles with the ability to interact with the surface of the two-dimensional materials via van der Waals interactions leading to subsequent quenching of the upconversion fluorescence. By contrast, in the presence of a complementary oligonucleotide

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Huggins, Ian J., Carlos A. Medina, Aaron D. Springer, et al. "Site Selective Antibody-Oligonucleotide Conjugation via Microbial Transglutaminase." Molecules 24, no. 18 (2019): 3287. http://dx.doi.org/10.3390/molecules24183287.

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Nucleic Acid Therapeutics (NATs), including siRNAs and AntiSense Oligonucleotides (ASOs), have great potential to drug the undruggable genome. Targeting siRNAs and ASOs to specific cell types of interest has driven dramatic improvement in efficacy and reduction in toxicity. Indeed, conjugation of tris-GalNAc to siRNAs and ASOs has shown clinical efficacy in targeting diseases driven by liver hepatocytes. However, targeting non-hepatic diseases with oligonucleotide therapeutics has remained problematic for several reasons, including targeting specific cell types and endosomal escape. Monoclonal

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Wang, Chungang, Zhanfang Ma, and Zhongmin Su. "Facile method to detect oligonucleotides with functionalized polydiacetylene vesicles." Sensors and Actuators B: Chemical 113, no. 1 (2006): 510–15. http://dx.doi.org/10.1016/j.snb.2005.03.106.

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Dissertations / Theses on the topic "Functionalized oligonucleotides"

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Matsuda, Shigeo. "Studies on the Photochemical Ligation of DNA and the Synthesis of Functionalized Oligonucleotides." 京都大学 (Kyoto University), 2001. http://hdl.handle.net/2433/150702.

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Lövdahl, Paul. "Towards DNA-Bodies : A Novel Polymer Structure for Biological Recognition." Thesis, Linnaeus University, School of Natural Sciences, 2010. http://urn.kb.se/resolve?urn=urn:nbn:se:lnu:diva-6187.

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<p><p>There are different kinds of recognition molecules that specifically can detect and bind target molecules. Antibodies, with their two light and two heavy chains can detect and bind any kind of antigens. Molecular imprinting is a technology to prepare specific polymers that selectively bind target molecules. The technology has received wide attention in recent years because it provides a viable method for creating a polymer that is complementary in shape and binding sites to a template. The synthesized polymer is called a molecularly imprinted polymer (MIP) or a plastibody. Molecular impr

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Honcharenko, Dmytro. "Conformationally Constrained Nucleosides, Nucleotides and Oligonucleotides : Design, Synthesis and Properties." Doctoral thesis, Uppsala universitet, Bioorganisk kemi, 2008. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-8887.

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This thesis is based on six original research publications describing synthesis, structure and physicochemical and biochemical analysis of chemically modified oligonucleotides (ONs) in terms of their potential diagnostic and therapeutic applications. Synthesis of two types of bicyclic conformationally constrained nucleosides, North-East locked 1',2'-azetidine and North locked 2',4'-aza-ENA, is described. Study of the molecular structures and dynamics of bicyclic nucleosides showed that depending upon the type of fused system they fall into two distinct categories with their respective internal

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Ming, Xin. "DNA containing 7-functionalized 7-deazapurines or 8-Oxo-7-thiaguanine: Synthesis of nucleosides, oligonucleotides and base pairing properties = 7-Funktionalisierte 7-Desazapurine oder 8-Oxo-7-Thiaguanine als Bausteine von DNA: Synthese von Nukleosiden, Oligonukleotiden und Basenpaarungs-Eigenschaften /." Osnabrück : [s.n.], 2008. http://opac.nebis.ch/cgi-bin/showAbstract.pl?sys=000254560.

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Pavey, John B. J. "The synthesis and properties of 2'-C-functionalised nucleotides." Thesis, University of Liverpool, 1997. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.367007.

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Knights, Sally Ann. "The study and synthesis of 2'-C-functionalised nucleosides." Thesis, University of Liverpool, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.343966.

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Wang, Xingwei. "Label-free DNA Sequence Detection Using Oligonucleotide Functionalized Fiber Probe with a Miniature Protrusion." Diss., Virginia Tech, 2006. http://hdl.handle.net/10919/28662.

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DNA is the substance that encodes the genetic information that cells need to replicate and to produce proteins. The detection of DNA sequences is of great importance in a broad range of areas including genetics, pathology, criminology, pharmacogenetics, public health, food safety, civil defense, and environmental monitoring. However, the established techniques suffer from a number of problems such as the bulky size, high equipment costs, and time-consuming algorithms so that they are limited to research laboratories and cannot be applied for in-vivo situations. In our research, we developed a

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Alughare, Zohre Eskandari, and Pedro M. R. Paulo. "Gold nanorods functionalized with DNA oligonucleotide probes for biosensing and plasmon-enhanced fluorescence detection." Master's thesis, 2017. http://hdl.handle.net/10400.1/10706.

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Gold nanorods display plasmon resonances that are very sensitive to the refraction index close to the particle’s surface. The site-selective functionalization of Plasmon hot-spots with bioreceptors is crucial to develop plasmonic sensors with improved response bycapturing the target species at the most sensitive regions of the particle. Firstly, we used surface immobilized biotin-functionalized gold nanorods for streptavidin sensing.The selective functionalization of the nanorods’ tips was achieved with a CTAB bilayer and using a thiol linker to attach the desired biotin functionality. T

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Books on the topic "Functionalized oligonucleotides"

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Nisman, Rozalia. Immobilization and characterization of oligonucleotides on functionalized substrates. 2002.

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Book chapters on the topic "Functionalized oligonucleotides"

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Bentolila, Laurent A. "Direct In Situ Hybridization with Oligonucleotide Functionalized Quantum Dot Probes." In Methods in Molecular Biology. Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-789-1_10.

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Ratajczak, Tomasz, Barbara Uszczyńska, Emilia Frydrych-Tomczak, and Marcin K. Chmielewski. "The “Clickable” Method for Oligonucleotide Immobilization Onto Azide-Functionalized Microarrays." In Methods in Molecular Biology. Springer New York, 2016. http://dx.doi.org/10.1007/978-1-4939-3136-1_3.

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Wang, Shunzhi, Michael McGuirk, Michael B. Ross, et al. "General and Direct Method for Preparing Oligonucleotide-Functionalized Metal–Organic Framework Nanoparticles*." In Spherical Nucleic Acids. Jenny Stanford Publishing, 2020. http://dx.doi.org/10.1201/9781003056690-15.

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Wang, Shunzhi, C. Michael McGuirk, Michael B. Ross, et al. "General and Direct Method for Preparing Oligonucleotide-Functionalized Metal-Organic Framework Nanoparticles*." In Spherical Nucleic Acids. Jenny Stanford Publishing, 2020. http://dx.doi.org/10.1201/9781003056690-36.

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Wang, Shunzhi, C. Michael McGuirk, Michael B. Ross, et al. "General and Direct Method for Preparing Oligonucleotide-Functionalized Metal-Organic Framework Nanoparticles*." In Spherical Nucleic Acids. Jenny Stanford Publishing, 2020. http://dx.doi.org/10.4324/9780429200151-36.

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Conference papers on the topic "Functionalized oligonucleotides"

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Polushin, Nikolai N. "Synthesis of highly functionalized oligonucleotides using novel modifying and branching phosphoramidite units." In XIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 1999. http://dx.doi.org/10.1135/css199902145.

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Gines, Guillaume, Mélanie Flaender, Camille Desiron, Christine Saint-Pierre, and Didier Gasparutto. "On support fluorescent assays based on functionalized oligonucleotides to monitor specific DNA repair activities." In XVth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2011. http://dx.doi.org/10.1135/css201112327.

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Nguyen, Thai Huu, and Qiao Lin. "An Aptamer-Functionalized Microfluidic Platform for Biomolecular Purification and Sensing." In ASME 2009 7th International Conference on Nanochannels, Microchannels, and Minichannels. ASMEDC, 2009. http://dx.doi.org/10.1115/icnmm2009-82142.

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Aptamers are oligonucleotides (DNA or RNA) that bind to chemical and biological analyte targets via affinity interactions. Through an in vitro synthetic process, aptamers can be developed for an extremely broad spectrum of analytes, such as small molecules, proteins, cells, viruses, and bacteria. Target recognition by aptamers is highly selective, as affinity interactions result in secondary aptamer conformational structures that specifically fit the target. The aptamer-target binding is also reversible and depends strongly on external stimuli such as pH and temperature. The specificity and st

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Calais, Theo, Thileepan Stalin, Vincent S. Joseph, and Pablo Valdivia y Alvarado. "DNA Nanotechnologies for the Design of Bio-Inspired Soft Nanocomposites With Reversible Rigidity." In ASME 2019 Conference on Smart Materials, Adaptive Structures and Intelligent Systems. American Society of Mechanical Engineers, 2019. http://dx.doi.org/10.1115/smasis2019-5568.

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Abstract Structures and mechanisms in soft robotics are primarily based on chemically versatile species such as hydrogels, polymers, or elastomers, thus offering great potential for the design of adaptive core properties. In particular, tunable rigidity is highly desirable to enable control of soft grippers or for advanced robot locomotion. However, most of the strategies explored so far rely on mechanisms, such as phase transitions or shape memory effects, that require heavy external hardware or have a limited range of tunable rigidity. In this work, we propose a novel strategy inspired by th

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Chen, Kok Hao, and Jong Hyun Choi. "DNA Oligonucleotide-Templated Nanocrystals: Synthesis and Novel Label-Free Protein Detection." In ASME 2009 International Mechanical Engineering Congress and Exposition. ASMEDC, 2009. http://dx.doi.org/10.1115/imece2009-11958.

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Semiconductor and magnetic nanoparticles hold unique optical and magnetic properties, and great promise for bio-imaging and therapeutic applications. As part of their stable synthesis, the nanocrystal surfaces are usually capped by long chain organic moieties such as trioctylphosphine oxide. This capping serves two purposes: it saturates dangling bonds at the exposed crystalline lattice, and it prevents irreversible aggregation by stabilizing the colloid through entropic repulsion. These nanocrystals can be rendered water-soluble by either ligand exchange or overcoating, which hampers their wi

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Wang, Xingwei, Juncheng Xu, Zhuang Wang, Kristie L. Cooper, Anbo Wang, and Chengdong Cao. "Oligonucleotide functionalized Fabry-Perot interferometric probe for DNA sequence detection." In Biomedical Optics (BiOS) 2007, edited by Samuel Achilefu, Darryl J. Bornhop, Ramesh Raghavachari, Alexander P. Savitsky, and Rebekka M. Wachter. SPIE, 2007. http://dx.doi.org/10.1117/12.697431.

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Sinha, Swati, Kunal Biswas, Angsuman Sarkar, et al. "Tuning of Bandstructure of Single—Walled Carbon Nanotube Functionalized with ssDNA Oligonucleotide Sequence." In 2018 IEEE Electron Devices Kolkata Conference (EDKCON). IEEE, 2018. http://dx.doi.org/10.1109/edkcon.2018.8770444.

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Dembska, Anna, and Joanna Kosman. "Pyrene functionalized oligonucleotide consists of two integrated operating domains: an i-motif and a harpin stem." In XVIth Symposium on Chemistry of Nucleic Acid Components. Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, 2014. http://dx.doi.org/10.1135/css201414305.

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