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Dissertations / Theses on the topic 'Furo[2'

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Published: 4 June 2021

Last updated: 25 July 2025

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1

Vaitiulionytė, Diana. "Furo[2,3-d]pirimidinų sintezė ir savybės." Master's thesis, Lithuanian Academic Libraries Network (LABT), 2006. http://vddb.library.lt/obj/LT-eLABa-0001:E.02~2006~D_20060613_174528-81935.

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We report herein on the results of N- and O-alkylation of 5-cyano-2-methylsulfanyl-4(3H)- pyrimidinone with 4-substituted ω-bromoacetophenones. Synthesized N-(phenacyl)-4- pyrimidinones and 4-(phenacyloxy)pyrimidines with suitable substituents in pyrimidine ring are versatile synthons for the preparation of fused pyrimidine heterocycles. Chemical properties of new furo[2,3-d]pyrimidines were investigated. The structure of synthesized compounds was confirmed by data of 1H NMR, IR and UV spectra.

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2

Wang, Yu-Pu Ph D. Massachusetts Institute of Technology. "I. [2 +2] Cycloaddition and benzannulation of 2-iodoynamides and application to the construction of highly substituted indoles : II. Synthesis of furo[2,3-g]thieno[2,3-e]indole via a benzannulation strategy." Thesis, Massachusetts Institute of Technology, 2015. http://hdl.handle.net/1721.1/101556.

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Thesis: Ph. D., Massachusetts Institute of Technology, Department of Chemistry, 2015.<br>Cataloged from PDF version of thesis.<br>Includes bibliographical references.<br>The synthesis and reactions of 2-iodoynamides were investigated. 2-Iodoynamides undergo efficient and regioselective [2 + 2] cycloaddition with ketene to produce cyclobutenones that are useful synthetic building blocks. Reaction of 2-iodoynamides and vinylketenes generated in situ from cyclobutenones proceeds via a pericyclic cascade mechanism to produce highly substituted 2-iodoanilines. Tandem strategies for the synthesis of

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3

Perry, Philip J. "Synthesis and biological evaluation of novel cytotoxic heterocylic compounds : furo[2,3-b]naphthoquinones and 2-aryl-4H-3,1-benzoxazin-4-ones." Thesis, De Montfort University, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.391202.

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Mauz, Tobias. "4-Hydrazono-1,3-oxazolidin-2-one 1,3,4-Oxadiazin-2-one und Furo[3,4-d]-pyrimidin-2,4,5-trione als Leitstrukturen neuer antimikrobieller Wirkstoffe Synthese, Analytik und Bestimmung der biologischen Aktivität /." [S.l.] : [s.n.], 2004. http://deposit.ddb.de/cgi-bin/dokserv?idn=971369089.

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5

Thibault, Charles. "Utilisation de la chimie ''click'' Diels-Alder pour la construction d'hétérocycles oxygénés bioactifs; synthèse d'anhydrides maléiques, de cadiolides, de furo[2,3-b]chromones et découverte inusitée du réarrangement des 3-acyl-2-alkoxyfuranes." Doctoral thesis, Université Laval, 2018. http://hdl.handle.net/20.500.11794/35274.

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Les travaux présentés dans cette thèse concernent l'utilisation de la chimie ''click'' Diels-Alder pour la construction d'hétérocycles oxygénés bioactifs. Dans un premier temps, une nouvelle méthodologie de synthèse versatile menant à des anhydrides maléiques disubstitués est illustrée par la synthèse de l'anhydride chaetomélique A (2.31a, inhibiteur nanomolaire de la FTase) ainsi que la synthèse d'un agent inducteur de la germination (1.26) et d'un nouveau bis-anhydride (1.27) utilisé comme agent de réticulation pour la fixation de cellules ou de tissus. En débutant avec des alcynes commerci

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6

Jacquelin, Jean-Marie. "Fonctionnalisation par métallation d'amino et d'hydroxy quinoléines : applications à la synthèse de furo quinoléines." Rouen, 1987. http://www.theses.fr/1987ROUES033.

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L'amino-2 quinoléine est fonctionnalisée par métallation en position 3. Les amino-3 et -4 quinoléines ont également été métallées respectivement sur les sommets 2 et 8 mais n'ont pu être fonctionnalisées par des électrophiles carbonés. Les hydroxy-2, -3 et -4 quinoléines masquées sous forme de carbamates sont lithiés régiosélectivement sur les carbones 3, 4 et 3 respectivement. Les dérivés ortho substitués préparés par réaction d'aldéhydes sur les intermédiaires lithiés sont utilisés pour la synthèse de furo-quinoléines

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7

Chi, Hung Nguyen. "Synthèse et étude de nouveaux analogues tetracycliques et tricycliques des ellipticines et aza-9 ellipticines." Paris 11, 1985. http://www.theses.fr/1985PA112290.

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La présente thèse concerne la synthèse de nouveaux analogues tétracycliques et tricycliques des Ellipticines et aza-9 Ellipticines, ainsi que l'étude de L'étude de leurs propriétés biologiques. L’étude de la lithiation des furo-et pyrrolo [3,2-c] pyridines présentée dans le premier chapitre montre que l'échange avec le ter. Butyl lithium s'effectue sur le sommet 2 de ces hétérocycles. Cela permet d'accéder à divers dérivés fonctionnalisés sur leur sommet 2 à partir desquels nous avons pu accéder d'une part à des pyrido [4,3-b] benzo [f] indoles et d'autre part à des pyrido [3',4': 4,5] pyrrolo

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8

Silva, Orivaldo Lopes da. "Incorporação de cálcio iônico em células ósseas induzida por campo elétrico." Universidade de São Paulo, 1995. http://www.teses.usp.br/teses/disponiveis/76/76132/tde-10062014-163725/.

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Acredita-se que sinais elétricos endógenos afetem remodelamento, metabolismo, reparo e crescimento ósseos. Existe uma ampla literatura que trata do efeito de sinais elétricos externos sobre as respostas de síntese, mitogênese e proliferação em osteoblastos e células ósseas in vitro. Acredita-se que as respostas fisiológicas ao estimulo elétrico sejam devidas a mecanismos celulares que envolvem variações na concentração citosólica de cálcio. No presente estudo esse efeito celular foi observado através da estimulação direta, por campo elétrico de intensidade fisiologicamente significativa de 10m

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9

Pizzuti, Lucas. "Síntese de 4-(fur-2-il)- e 4-(tien-2-il)-pirimidinas a partir de β-Alcoxivinil trifluormetil cetonas". Universidade Federal de Santa Maria, 2005. http://repositorio.ufsm.br/handle/1/10401.

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Conselho Nacional de Desenvolvimento Científico e Tecnológico<br>The cyclocondensation of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones (heteroaryl = furyl and thienyl) with urea and amidines (acetamidine, benzamidine, guanidine, 1H-pyrazole-1-carboxamidine and 2-methyl-2-thiopseudourea) for synthesis of two 4-(2-heteroaryl)-6-trifluoromethylpyrimidinones and a series of ten 4-(2-heteroaryl)-6-trifluoromethylpyrimidines is reported. The reaction of the 1,1,1-trifluoro-4-methoxy-4-(2-heteroaryl)-3-buten-2-ones with urea was carried out in the presence of boron trifluoride ethera

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10

Hadrovic, Banina. "A study of TRPV1 and TRPV4 ion channels in the beta cells by using fura-2 based microfluorometry." Thesis, Mälardalen University, School of Sustainable Development of Society and Technology, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:mdh:diva-7350.

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<p>The calcium ion (Ca<sup>2+</sup>) is an important ion that regulates many cellular functions including exocytosis, contraction of muscles, neural functions, fertilization and cell division. In the plasma membrane of cells there are different Ca<sup>2+</sup> channels, including the transient receptor potential (TRP) family of cation channels. The TRP channels are activated by physical stimuli like temperature, stretch, osmolality, and also various ligands. These channels are divided into seven subfamilies, namely TRPC, TRPV, TRPM, TRPML, TRPA, TRPP, and TRPN.</p><p> </p><p>TRP channels can r

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11

Beurg, Maryline. "Couplage excitation-contraction des cellules musculaires striées : étude des variations transitoires de calcium par imagerie de fura-2." Bordeaux 1, 1995. http://www.theses.fr/1995BOR10530.

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Le couplage excitation-variation transitoire de ca2+ (e-vt) constitue l'etape cle du couplage e-c des muscles squelettiques. A l'aide de la technique d'imagerie du fura-2, nous avons suivi la dynamique et la distribution spatiale de la concentration de calcium intracellulaire pendant le developpement des myotubes de rat, de souris dysgeniques et humains en culture. Les myotubes de rat in vitro presentent temporairement un stade dit quiescent durant lequel ces cellules sont incapables de se contracter alors qu'elles possedent un couplage e-vt de ca2+ fonctionnel. Lors du couplage e-vt, la liber

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12

Trzaska-Richter, Christine. "Furor teutonicus : das römische Germanenbild in Politik und Propaganda von den Anfängen bis zum 2. Jahrhundert n. Chr. /." Trier : WVT, Wissenschaftlicher Verl. Trier, 1991. http://catalogue.bnf.fr/ark:/12148/cb366770200.

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13

Lascombe, Marie-Laure. "Le couplage excitation-contraction dans les cellules musculaires striées normales et dysgéniques : étude par imagerie de fluorescence de fura-2." Bordeaux 1, 1992. http://www.theses.fr/1992BOR10519.

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Pour etudier les mecanismes du couplage excitation-contraction dans les cellules musculaires striees normales et dysgeniques (mdg/mdg) nous avons suivi la dynamique et la distributionspatiale des variations de la ca#2#+#i par videomicroscopie de fluorescence et traitement des images. Dans les myotubes normaux, nous avons trouve: a) l'existence, dans une etape de la myogenese, d'un couplage excitation-augmentation de la ca#2#+#i n'induisant pas de contraction; b) sous l'action de l'acetylcholine, la variation calcique est biphasique avec d'abord la liberation de calcium apparemment module par u

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14

Castro, Kraftchenko Joel, and kraf0005@flinders edu au. "STORE OPERATED Ca2+ CHANNELS IN LIVER CELLS: REGULATION BY BILE ACIDS AND A SUB-REGION OF THE ENDOPLASMIC RETICULUM." Flinders University. Medicine, 2008. http://catalogue.flinders.edu.au./local/adt/public/adt-SFU20080826.135311.

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Cholestasis is an important liver pathology. During cholestasis bile acids accumulate in the bile canaliculus affecting hepatocyte viability. The actions of bile acids require changes in the release of Ca2+ from intracellular stores and in Ca2+ entry. The target(s) of the Ca2+ entry pathway affected by bile acids is, however, not known. The overall objective of the work described in this thesis was to elucidate the target(s) and mechanism(s) of bile acids-induced modulation of hepatocytes calcium homeostasis. First, it was shown that a 12 h pre-incubation with cholestatic bile acids (to mimic

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15

Lord, Elin. "Olfactory discrimination of aliphatic 2-ketones and 1-alcohols in South African fur seals (Arctocephalus pusillus pusillus)." Thesis, Linköpings universitet, Institutionen för fysik, kemi och biologi, 2009. http://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-18932.

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Odor discrimination ability was tested in four female South African fur seals (Arctocephalus pusillus pusillus) using a food-rewarded two-choice instrumental conditioning paradigm. The seals’ ability to distinguish between members of homologous series of aliphatic ketones (2-butanone to 2-heptanone) and alcohols (1-butanol to 1-heptanol) was assessed. The results showed that three out of four seals successfully discriminated between all of their stimulus combinations in both classes of odorants. One seal succeeded to reach the discrimination criterion with all 2-ketones but failed with all 1-a

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16

Pflieger, Dominique. "Antiappetants pour insectes phytophages : synthese d'analogues de l'azadirachtine et de la bisabolangelone." Université Louis Pasteur (Strasbourg) (1971-2008), 1988. http://www.theses.fr/1988STR13149.

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17

Scanlon, Mary. "Cellular mechanism of neutrophil chemotaxis: the role of CA⁺², as viewed with the fluorescent dye, FURA-2, in the polarization of human polymorphonuclear leukocytes following stimulation with the chemoattractant, F-Methionyl-Leucyl-Phenylalanine: a thesis." eScholarship@UMMS, 1987. https://escholarship.umassmed.edu/gsbs_diss/320.

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The mechanism by which a cell translates a spatially oriented, extracellular signal into a change in morphology and behavior is the key to understanding many biological processes. In order to investigate this general phenomenon, I have studied the chemotactic response of human polymorphonuclear leukocytes (PMN's) to f-methionyl-leucyl-phenylalanine (fMLP). Stimulation of PMN's with fMLP produces a plethora of intracellular events, including increases in cytosolic Ca+2. PMN's are also morphologically and behaviorally polarized by stimulation with chemoattractant; the membrane components and cyt

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18

Westerlund, Johanna. "Pulsatile insulin release from single islets of Langerhans." Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2000. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-494.

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<p>Insulin release from single islets of Langerhans is pulsatile. The secretory activities of the islets in the pancreas are coordinated resulting in plasma insulin oscillations. Nutrients amplitude-regulate the insulin pulses without influencing their frequency. Diabetic patients show an abnormal plasma insulin pattern, but the cause of the disturbance remains to be elucidated. Ithe present thesis the influence of the cytoplasmic calcium concentratio([Ca<sup>2+</sup>]<sub>i</sub>) and cell metabolism on pulsatile insulin release was examined in single islets of Langerhans from <i>ob/ob</i>-mi

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19

Liu, Li. "Roles of PMCA Isoforms in Ca²⁺-Homeostasis and Contractility of Bladder Smooth Muscle: Evidence from PMCA Gene-Ablated Mice." Cincinnati, Ohio : University of Cincinnati, 2007. http://rave.ohiolink.edu/etdc/view.cgi?acc_num=ucin1178307168.

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Thesis (Ph.D.)--University of Cincinnati, 2007.<br>Advisor: Richard J. Paul. Title from electronic thesis title page (viewed Apr. 4, 2009). Keywords: PMCA (human gene symbols; ATP2B); SERCA2 (human gene symbols; ATP2A2); NCX; bladder smooth muscle; Ca²⁺ homeostasis; gene-altered mice. Ca²⁺ waves; Ca²⁺ sparks; Fura-PE3; Fluo-4; Indo-1; multi-photon microscopy. Includes abstract. Includes bibliographical references.

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20

Egunlusi, Ayodeji Olatunde. "Novel tricycloundecane derivatives as potential N-methyl-Daspartate receptor and calcium channel inhibitors for neuroprotection." Thesis, University of the Western Cape, 2014. http://hdl.handle.net/11394/3904.

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>Magister Scientiae - MSc<br>This study focused on the synthesis of a series of novel tricycloundecane derivatives and evaluation of these compounds for neuroprotection using the fluorescent ratiometric calcium assay that indicates the ability of the test compounds to inhibit NMDA receptors and VGCC. The cycloaddition reaction between p-benzoquinone and monomerised dicyclopentadiene yielded tricycloundeca- 4,9-diene-3,6-dione which was used as the base structure and further derivatised. These derivatives were conjugated with benzylamine to form a series of imines and amines. A total of 10 comp

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Schröder, Christian. "Die Haftung fur Verstosse gegen Privacy Policies und Codes of Conduct nach US-amerikanischem und deutschem Recht : Zugleich ein beitrag zur Rechtsnatur von Datenschutzerklärungen, Verhaltensregeln gem, [paragraph] 38a BDSG und Unternehmensregelungen gem. [paragraph] 4c Abs. 2 BDSG /." Baden-Baden : Nomos, 2007. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=016138110&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Ahmed, Meftun. "Oscillatory Ca²⁺ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine". Doctoral thesis, Uppsala University, Department of Medical Cell Biology, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1408.

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<p>Oscillations in cytoplasmic Ca<sup>2+</sup> concentration ([Ca<sup>2+</sup>]<sub>i</sub>) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca<sup>2+</sup>]<sub> i</sub>. In the present study, microfluorometric technique was used to evaluate the role of amino acids, glucagon, ryanodine and caffeine on the generation and maintenance of [Ca<sup>2+</sup>]<sub> i</sub> oscillations and transients in individual murine β-cells and isolated mouse pancreatic isl

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23

Ahmed, Meftun. "Oscillatory Ca2+ signaling in glucose-stimulated murine pancreatic β-cells : Modulation by amino acids, glucagon, caffeine and ryanodine". Doctoral thesis, Uppsala universitet, Institutionen för medicinsk cellbiologi, 2001. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-1408.

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Oscillations in cytoplasmic Ca2+ concentration ([Ca2+]i) is the key signal in glucose-stimulated β-cells governing pulsatile insulin release. The glucose response of mouse β-cells is often manifested as slow oscillations and rapid transients of [Ca2+] i. In the present study, microfluorometric technique was used to evaluate the role of amino acids, glucagon, ryanodine and caffeine on the generation and maintenance of [Ca2+] i oscillations and transients in individual murine β-cells and isolated mouse pancreatic islets. The amino acids glycine, alanine and arginine, at around their physiologica

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24

CHEN, WEIWEN. "Le recepteur de la cholecystokinine couple a la mobilisation du calcium intracellulaire : etude sur des cellules isolees d'acini pancreatiques et de muqueuses gastrique de rat." Paris 7, 1988. http://www.theses.fr/1988PA077035.

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25

ROSSI, LUCREZIA SILVANA. "LA LEGITTIMA DIFESA NEL DOMICILIO (ART. 52 C. 2-4 C.P.) UN¿INDAGINE TRA STORIA, COMPARAZIONE, TEORIA E PRASSI." Doctoral thesis, Università degli Studi di Milano, 2021. http://hdl.handle.net/2434/852006.

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L’elaborato tratta il delicato tema della legittima difesa esercitata nel domicilio, che è stato oggetto di due riforme negli ultimi quindici anni – prima nel 2006, poi nel 2019 –, suscitando diffuse critiche e contrastanti pareri in ordine alla sua esatta portata. La grande attenzione pubblica per l’istituto e i due interventi legislativi hanno stimolato l’interesse e il desiderio di approfondire l’origine, la ratio e l’evoluzione della scriminante di cui all’art. 52 c.p. Lo scopo della presente indagine è duplice: da una parte, si è cercato di comprendere le esigenze sottostanti alle rifor

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WEBER, M. ELISABETH. "Transporteurs de pyrimidines chez saccharomyces cerevisiae : sequence de deux genes et prediction de structure des proteines correspondantes." Université Louis Pasteur (Strasbourg) (1971-2008), 1987. http://www.theses.fr/1987STR13197.

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27

Tsai, Cheng-Che, та 蔡政哲. "Investigation of phosphine-mediated or catalyzed reactions : synthesis of furo[3,2-c]chromen-4-one derivatives or β-acylated 2-arylidene-1,3-indandiones". Thesis, 2014. http://ndltd.ncl.edu.tw/handle/72881699469199977003.

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Mauz, Tobias [Verfasser]. "4-Hydrazono-1,3-oxazolidin-2-one 1,3,4-Oxadiazin-2-one und Furo[3,4-d]-pyrimidin-2,4,5-trione als Leitstrukturen neuer antimikrobieller Wirkstoffe : Synthese, Analytik und Bestimmung der biologischen Aktivität / vorgelegt von Tobias Mauz." 2004. http://d-nb.info/971369089/34.

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Tsung-HanKuo and 郭宗翰. "Synthesis of Benzo[b]furo[4,3,2-mn]acridines and Benzo[b]naphtho[2,3-f]azepines from 2-Amino-1,4-naphthoquinones via Electrophilic and Metallic Oxidative Reaction." Thesis, 2015. http://ndltd.ncl.edu.tw/handle/03460068405113249612.

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碩士<br>國立成功大學<br>化學系<br>103<br>SUMMARY Benzo[b]furo[4,3,2-mn]acridine and benzo[b]naphtho[2,3-f] azepine have been found possess broad biological activities, such as antifungal, antivirus and antitumor. Their skeleton has also been attracted considerable attention in many literature. Electrophilic reaction and metallic oxidative reaction were occupied an important position in organic chemistry. In the past decades, they have been widely used to synthesis of various types of organic compounds. This thesis will be developed two novel and efficient methods for synthesis of Benzo[b]furo[4,3,2-mn]ac

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Lee, Chia-Jui, та 李家睿. "Direct β-Acylation of 2-Arylidene-1,3-indandiones withAcyl Chlorides Catalyzed by OrganophosphanesPreparation of Furo[3,2-c]coumarins from 3-cinnamoyl-4-hydroxy-2H-chromen-2-ones and Acyl Chlorides: A Bu3P-Mediated C-Acylation/Cyclization SequenceSynthesis of Functionalized Furans via Chemoselective Reduction/Wittig reaction Using Catalytic Triethylamine and Phosphine". Thesis, 2016. http://ndltd.ncl.edu.tw/handle/58559388773676205184.

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博士<br>國立臺灣師範大學<br>化學系<br>104<br>In part I, we have developed an organophosphane-catalyzed direct β-acylation of a series of conjugated systems bearing ketone, amide and ester functionalities using acyl chlorides as trapping reagents. A wide variety of highly functional ketone derivatives were generated efficiently under very mild conditions with high yields according to our protocol. Our adducts can even be utilized as important building blocks for the synthesis of functional tri/tetracyclic pyridazine derivatives. In part II, electrophilic addition of acyl chlorides to 3- cinnamoyl-4-hydroxy

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Geibel, Uta. "Entwicklung und Validierung eines neuen Schnellmessverfahrens für Adrenalin im Blutserum." Doctoral thesis, 2017. http://hdl.handle.net/11858/00-1735-0000-0023-3F20-0.

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TSAI, WEIN-SHIANG, and 蔡文翔. "Fura-2 loading and its use as an indicator of cytosolic free calcium in cardiomyocytes." Thesis, 1992. http://ndltd.ncl.edu.tw/handle/55905878881177513301.

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碩士<br>輔仁大學<br>生物學研究所<br>80<br>Fura-2乃目前常用來測量細胞內自由態鈣進離子的一種螢光劑。本研究乃探fura-2在新生大白鼠心肌細胞內之分布情形。結果顯示隨著處理時間的增加，細胞內fura-2螢光強度亦隨之增強。但fura-2在細胞內之分布並不均勻：細胞質，細胞核、粒線體，溶體內均有fura-2。而細胞在fura-2 AM 處理後再於37℃下靜置10-30 分鐘則有利於fura-2 AM 之解。但細胞先在4℃ 預冷10分鐘後再和fura-2 AM 在37℃一起培養或 fura-2 AM 和細胞在15℃下作用，fura-2在細胞內之分布情況並無進一步之改善。本研究顯示fura-2 AM 在心肌細胞內均勻分布之最佳處理方式為心肌細胞和5uM 之fu ra-2 AM 於37℃下作用20分鐘後，再水解20分鐘，此可使84% 心肌細胞內fura-2呈均勻分布，且大都位於細胞質中。

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Balakrishnan, Saju. "Zytosolisches Calcium in murinen Hirnstamm-Motoneuronen wird differenziert von Mitochondrien reguliert." Doctoral thesis, 2006. http://hdl.handle.net/11858/00-1735-0000-0006-ABC0-A.

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Gonçalves, Alexandre Manuel Monteiro. "T3 HORMONE AS AN EFFECTIVE THERAPY FOR HEART FAILURE WITH PRESERVED EJECTION FRACTION: Effects on Ca2+ transients and contractility." Master's thesis, 2018. http://hdl.handle.net/10316/81936.

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Dissertação de Mestrado em Investigação Biomédica apresentada à Faculdade de Medicina<br>A insuficiência cardíaca com fração de ejeção preservada (ICFEP) constitui um frequente problema clínico, mas até hoje, nenhuma intervenção terapêutica parece modular o seu desfecho clínico. Alguns doentes com ICFEP possuem alterações no eixo hormonal da tiroide e é já conhecido o impacto da influência destas hormonas sobre o sistema cardiovascular. Neste projeto, testamos a hipótese de que administração oral preventiva com triiodotironina (T3) pode prevenir o desenvolvimento de ICFEP. Iniciou-se às 14 sem

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Esteves, Herculano José Rodrigues. "O crime de furto qualificado previsto no artigo 204 nº 2 al. e) do Código Penal e a definição legal de arrombamento." Master's thesis, 2017. http://hdl.handle.net/10400.14/23783.

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A compreensão do crime de furto qualificado por penetração por arrombamento em certos espaços fechados exige a análise da conceptualização da norma material e da norma que define o referido modo de execução e a análise da complexa conexão que se estabelece entre elas. Dessa exegese resulta que é a norma incriminatória que fixa aqueles espaços. Entendendo-se (como deve entender-se) o conceito “casa” em sentido amplo e heterogéneo mas sempre como espaço autónomo, então a norma material não abrange o “lugar fechado dela dependente” exclusivamente previsto na norma definitória. A exigência de inte

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Have, Meike von. "Charakterisierung ATP- und K+-induzierter Ca2+-Ströme und Untersuchung der Interaktion von ATP mit Ca2+-Kanälen an DRG-Neuronen und HEK-293-Zellen mittels Fura-2-Mikrofluorimetrie /." 2004. http://bvbr.bib-bvb.de:8991/F?func=service&doc_library=BVB01&doc_number=012924477&line_number=0001&func_code=DB_RECORDS&service_type=MEDIA.

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Genty, Hélène. "Étude de l'association du réticulum endoplasmique lisse marqué par le récepteur du facteur autocrine de motilité avec les mitochondries." Thèse, 2003. http://hdl.handle.net/1866/14627.

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Kortus, Štěpán. "Vápníková signalizace magnocelulárních neuronů supraoptického jádra potkanů." Doctoral thesis, 2019. http://www.nusl.cz/ntk/nusl-409248.

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The magnocellular neurosecretory cells (MNCs) of the hypothalamus project axons from the supraoptic nucleus to the posterior pituitary gland, where they secrete either oxytocin or vasopressin into the circulation. Oxytocin is important for delivery at birth and is essential for milk ejection during suckling. Vasopressin primarily promotes water reabsorption in the kidney to maintain body fluid balance. The profile of oxytocin and vasopressin secretion is principally determined by the pattern of action potentials initiated at the cell bodies in the hypothalamus. MNCs principally secrete hormone

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Lavalle, Maria. "Rat protease-activated receptor–1 (rPAR1) expression and characterization in Sf9 cells." Thèse, 2014. http://hdl.handle.net/1866/11761.

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Connue pour son rôle dans la cascade de coagulation, la thrombine, une protéase à sérine, peut également agir par l’intermédiaire de PAR1, un récepteur activé par protéase et couplé aux protéines G liant le GTP (GPCR). La thrombine se lie et clive l’extrémité N-terminale du PAR1 entre l’Arg41 et la Ser42, exposant une nouvelle extrémité terminale qui agit elle-même comme un ligand. La thrombine et une séquence peptidique de cinq acides aminés, composée des résidus Ser42 à Arg46, nommée PAR1-AP, déclenchent dans diverses cellules de mammifères une réponse intracellulaire comportant une composan

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