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Journal articles on the topic 'G-SYNUCLEIN'

Author: Grafiati

Published: 2 June 2025

Last updated: 31 July 2025

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1

Chen, Chiung-Mei, Chien-Yu Yen, Wan-Ling Chen, et al. "Pathomechanism Characterization and Potential Therapeutics Identification for Parkinson’s Disease Targeting Neuroinflammation." International Journal of Molecular Sciences 22, no. 3 (2021): 1062. http://dx.doi.org/10.3390/ijms22031062.

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Parkinson’s disease (PD) is a common neurodegenerative disorder characterized by the loss of dopaminergic (DAergic) neurons and the presence of α-synuclein-containing Lewy bodies. The unstructured α-synuclein forms insoluble fibrils and aggregates that result in increased reactive oxygen species (ROS) and cellular toxicity in PD. Neuroinflammation engaged by microglia actively contributes to the pathogenesis of PD. In this study, we showed that VB-037 (a quinoline compound), glycyrrhetic acid (a pentacyclic triterpenoid), Glycyrrhiza inflata (G. inflata, a Chinese herbal medicine), and Shaoyao

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2

Barinova, K. V., A. K. Melnikova, E. V. Schmalhausen, and V. I. Muronetz. "A rational approach to obtaining high-specific polyclonal antibodies against recombinant alpha-synuclein." Biomeditsinskaya Khimiya 64, no. 3 (2018): 276–82. http://dx.doi.org/10.18097/pbmc20186403276.

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The approach for the quick and efficient production ofpolyclonal antibodies tothe target antigen alpha-synuclein has been proposed. Two methods have been employed to purify specific rabbit polyclonal antibodies against recombinant human alpha-synuclein, produced by subcutaneous immunization with complete Freund's adjuvant. It was shown that purification on CNBr-activated Sepharose with immobilized alpha-synuclein resulted in antibody preparation with rabbit serum histidine-rich glycoprotein as a contaminant. Two-stage antibody purification procedure first on Sepharose with immobilized protein

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3

Büttner, Sabrina, Lukas Habernig, Filomena Broeskamp та ін. "Endonuclease G mediates α-synuclein cytotoxicity during Parkinson's disease". EMBO Journal 32, № 23 (2013): 3041–54. http://dx.doi.org/10.1038/emboj.2013.228.

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4

Soukup, Viktor, Marta Kalousová, Otakar Capoun, et al. "Panel of Urinary Diagnostic Markers for Non-Invasive Detection of Primary and Recurrent Urothelial Urinary Bladder Carcinoma." Urologia Internationalis 95, no. 1 (2015): 56–64. http://dx.doi.org/10.1159/000368166.

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Objectives: To determine the combination of urinary protein markers for noninvasive detection of primary and recurrent urothelial bladder carcinomas. Methods: Urinary concentrations of 27 biomarkers (NSE, ATT, AFABP, Resistin, Midkine, Clusterin, Uromodulin, ZAG2, HSP27, HSP 60, NCAM1/CD56, Angiogenin, Calreticulin, Chromogranin A, CEACAM1, CXCL1, IL13Ra2, Progranulin, VEGFA, CarbAnhydIX, Annexin-V, TIM4, Galectin1, Cystatin B, Synuclein G, ApoA1 and ApoA2) were assessed by enzyme-linked immunosorbent assay or by electrochemiluminiscence immunoassay. Results: During the primary diagnostics, a

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5

Tripodi, Farida, Ermelinda Falletta, Manuela Leri, et al. "Anti-Aging and Neuroprotective Properties of Grifola frondosa and Hericium erinaceus Extracts." Nutrients 14, no. 20 (2022): 4368. http://dx.doi.org/10.3390/nu14204368.

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Nutrition has relevant consequences for human health and increasing pieces of evidence indicate that medicinal mushrooms have several beneficial effects. One of the main issues in Western countries is represented by the challenges of aging and age-related diseases, such as neurodegenerative disorders. Among these, Parkinson’s disease (PD) affects 10 million people worldwide and is associated with α-synuclein misfolding, also found in other pathologies collectively called synucleinopathies. Here, we show that aqueous extracts of two edible mushrooms, Grifola frondosa and Hericium erinaceus, rep

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6

Yabuki, Yasushi, Kohei Maeda, Tomohiro Mizobata, Yasushi Kawata, Sefan Asamitsu та Norifumi Shioda. "RNA G-quadruplexes accelerate liquid-to-solid transition of α-synuclein." Proceedings for Annual Meeting of The Japanese Pharmacological Society 94 (2021): 2—O—B2–4. http://dx.doi.org/10.1254/jpssuppl.94.0_2-o-b2-4.

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7

Golebiewska, Urszula, Yuanjian Guo, Narindra Khalikaprasad, Cassandra Zurawsky, V. Siddhartha Yerramilli та Suzanne Scarlata. "γ-Synuclein Interacts with Phospholipase Cβ2 to Modulate G Protein Activation". PLoS ONE 7, № 8 (2012): e41067. http://dx.doi.org/10.1371/journal.pone.0041067.

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8

Stefaniuk, Catherine M., Quinn Ostrom, Jill Barnholtz-Sloan, Joseph Willis та Robert W. Maitta. "Elevation of Plasma α-Synuclein Levels Is Diagnostic of Malignant or Invasive Central Nervous System Neoplasms". Blood 126, № 23 (2015): 5597. http://dx.doi.org/10.1182/blood.v126.23.5597.5597.

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Abstract α-synuclein belongs to a family of small proteins and has been described as an important pathologic mediator of neurodegenerative diseases grouped as synucleinopathies such as Parkinson's Disease and Dementia with Lewy Bodies. It is extensively expressed in the central nervous system (CNS); however, its physiologic function is not known though it may involve mediating dopamine neurotransmitter release. Additionally, it is expressed in the hematopoietic system in erythroid precursors and megakaryocytes in bone marrow, as well as erythrocytes and platelets in peripheral blood. More impo

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9

Maeda, Kohei, Yasushi Yabuki, Sefan Asamitsu та ін. "Cellular stress-induced formation of RNA G-quadruplexes accelerates α-Synuclein aggregation". Proceedings for Annual Meeting of The Japanese Pharmacological Society 95 (2022): 1—SS—26. http://dx.doi.org/10.1254/jpssuppl.95.0_1-ss-26.

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10

Docimo, Teresa, Rita Celano, Alessia Lambiase, et al. "Exploring Influence of Production Area and Harvest Time on Specialized Metabolite Content of Glycyrrhiza glabra Leaves and Evaluation of Antioxidant and Anti-Aging Properties." Antioxidants 13, no. 1 (2024): 93. http://dx.doi.org/10.3390/antiox13010093.

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Calabrian Glycyrrhiza glabra is one of the most appreciated licorice varieties worldwide, and its leaves are emerging as a valuable source of bioactive compounds. Nevertheless, this biomass is usually discarded, and its valorization could contribute to boost the economic value of the licorice production chain. In this study, the effects of production area and harvest time on the specialized metabolite content of G. glabra leaves (GGL) and also the antioxidant and anti-aging properties are evaluated to explore the potential of this untapped resource and to select the most optimal harvesting pra

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11

Raghavan, Kadalraja, Vidyasagar Devaprasad Dedeepiya, Nobunao Ikewaki, et al. "Improvement of behavioural pattern and alpha-synuclein levels in autism spectrum disorder after consumption of a beta-glucan food supplement in a randomised, parallel-group pilot clinical study." BMJ Neurology Open 4, no. 1 (2022): e000203. http://dx.doi.org/10.1136/bmjno-2021-000203.

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BackgroundAutism spectrum disorders (ASDs) are a wide range of behavioural disabilities for which there are no definite interventional modalities available. Remedial therapies remain the only option but with varying outcomes. We have evaluated the Childhood Autism Rating Scale (CARS) and alpha-synuclein levels in this parallel-group, multiple-arm pilot clinical study after supplementation with a biological response modifier beta-glucan food supplement (Nichi Glucan).MethodsSix subjects with ASD (n=6) Gr. 1 underwent conventional treatment comprising remedial behavioural therapies and L-carnosi

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12

Pirota, Valentina, Federica Rey, Letizia Esposito та ін. "Effective lowering of α-synuclein expression by targeting G-quadruplex structures within the SNCA gene". International Journal of Biological Macromolecules 277 (жовтень 2024): 134417. http://dx.doi.org/10.1016/j.ijbiomac.2024.134417.

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13

Da Luo, *.-Zhong, Yu-Li Liu, Yufeng Jane Tseng, and Wen-Sung Lai. "A NEW HOPE FOR MULTIPLE SYSTEM ATROPHY: A TRANSLATIONAL RESEARCH OF A NOVEL NMDAR RECEPTOR MODULATOR FROM PRECLINICAL MODELS TO PATIENTS." International Journal of Neuropsychopharmacology 28, Supplement_1 (2025): i76—i77. https://doi.org/10.1093/ijnp/pyae059.133.

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Abstract Background NMDA receptor (NMDAR) is an essential glutamate receptor and as a contributor to neurodegenerative disorder1,2. Until now, NMDAR (especially glycine modulatory site (GMS) of the NMDARs) has been proposed to be a potential therapeutic target for the treatment of neurological disorders, such as multiple system atrophy (MSA)3. MSA, an atypical parkinsonism, is a fatal and rapidly progressive neurodegenerative disease with autonomic dysfunction and cerebellar deficits4-6. Up to now, the etiology and pathogenesis of MSA remains unclear4. One potential mechanism in MSA is accumul

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14

Chen, Jin, Zi-Jian Guo, Wei-Li Wang, and Lin-Fang Jin. "Expression of synuclein g in gastric carcinoma and its relationship with MMP-2 and MMP-9." World Chinese Journal of Digestology 16, no. 30 (2008): 3400. http://dx.doi.org/10.11569/wcjd.v16.i30.3400.

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15

Sakamoto, Masahiro, Shigeki Arawaka, Susumu Hara та ін. "Contribution of endogenous G-protein-coupled receptor kinases to Ser129 phosphorylation of α-synuclein in HEK293 cells". Biochemical and Biophysical Research Communications 384, № 3 (2009): 378–82. http://dx.doi.org/10.1016/j.bbrc.2009.04.130.

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16

Valek, Lucie, and Irmgard Tegeder. "Failure of Diphtheria Toxin Model to Induce Parkinson-Like Behavior in Mice." International Journal of Molecular Sciences 22, no. 17 (2021): 9496. http://dx.doi.org/10.3390/ijms22179496.

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Rodent models of Parkinson’s disease are based on transgenic expression of mutant synuclein, deletion of PD genes, injections of MPTP or rotenone, or seeding of synuclein fibrils. The models show histopathologic features of PD such as Lewi bodies but mostly only subtle in vivo manifestations or systemic toxicity. The models only partly mimic a predominant loss of dopaminergic neurons in the substantia nigra. We therefore generated mice that express the transgenic diphtheria toxin receptor (DTR) specifically in DA neurons by crossing DAT-Cre mice with Rosa26 loxP-STOP-loxP DTR mice. After defin

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17

Сергеева, Татьяна Николаевна, Владимир Николаевич Николенко, Юлия Николаевна Кузнецова, and Валерий Георгиевич Сергеев. "PROLONGED BAKTERIOPHAGAL INFECTION OF GUT MICROBIOTA REDUCES THE EXPRESSION OF ALPHA-SYNUCLEIN IN THE RAT PANETH CELLS." Морфология, no. 4-5 (September 30, 2020): 60–65. http://dx.doi.org/10.34922/ae.2020.158.4.009.

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Цель - исследовать интенсивность экспрессии белка альфа-синуклеина клетками Панета у крыс в норме и условиях длительного бактериофагального инфицирования микробиоты. Материал и методы. Экспериментальные исследования проведены на 12 половозрелых крысах-самцах линии Вистар массой 280-320 г. Крысам основной группы (n=7) еженедельно на протяжении 12 нед ректально вводили 0,5 мл раствора, содержащего смесь бактериофагов против 14 патогенов человека (Microgen, Россия). Однократная доза вводимой бактериофагальной смеси содержала 0,5×10ед./мл каждого фага. Животные контрольной группы (n=5) получали по

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18

Dumitriu, A., C. D. Pacheco, J. B. Wilk, et al. "Cyclin-G-associated kinase modifies -synuclein expression levels and toxicity in Parkinson's disease: results from the GenePD Study." Human Molecular Genetics 20, no. 8 (2011): 1478–87. http://dx.doi.org/10.1093/hmg/ddr026.

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19

Colucci, Fabiana, Micol Avenali, Rosita De Micco, et al. "Ambroxol as a disease-modifying treatment to reduce the risk of cognitive impairment inGBA-associated Parkinson’s disease: a multicentre, randomised, double-blind, placebo-controlled, phase II trial. The AMBITIOUS study protocol." BMJ Neurology Open 5, no. 2 (2023): e000535. http://dx.doi.org/10.1136/bmjno-2023-000535.

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BackgroundHeterozygous mutations in theGBAgene, encoding the lysosomal enzyme β-glucocerebrosidase (GCase), are the most frequent genetic risk factor for Parkinson’s disease (PD).GBA-related PD (GBA-PD) patients have higher risk of dementia and reduced survival than non-carriers. Preclinical studies and one open-label trial in humans demonstrated that the chaperone ambroxol (ABX) increases GCase levels and modulates α-synuclein levels in the blood and cerebrospinal fluid (CSF).Methods and analysisIn this multicentre, double-blind, placebo-controlled, phase II clinical trial, we randomise patie

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20

Vega-Galvez, Antonio, Luis S. Gomez-Perez, Francisca Zepeda, et al. "Assessment of Bio-Compounds Content, Antioxidant Activity, and Neuroprotective Effect of Red Cabbage (Brassica oleracea var. Capitata rubra) Processed by Convective Drying at Different Temperatures." Antioxidants 12, no. 9 (2023): 1789. http://dx.doi.org/10.3390/antiox12091789.

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Parkinson’s disease (PD) is the second most common neurodegenerative disorder, and no efficient therapy able to cure or slow down PD is available. In this study, dehydrated red cabbage was evaluated as a novel source of bio-compounds with neuroprotective capacity. Convective drying was carried out at different temperatures. Total phenolics (TPC), flavonoids (TFC), anthocyanins (TAC), and glucosinolates (TGC) were determined using spectrophotometry, amino acid profile by LC-DAD and fatty acid profile by GC-FID. Phenolic characterization was determined by liquid chromatography-high-resolution ma

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21

Loiodice, S., A. Hafidi, and F. Durif. "P.1.g.008 Levodopa chronic treatment promotes reinforcing properties of pramipexole in alpha-synuclein rat model of Parkinson's disease." European Neuropsychopharmacology 25 (September 2015): S242. http://dx.doi.org/10.1016/s0924-977x(15)30268-6.

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22

Bentea, Eduard, der Perren Anke Van, Liefferinge Joeri Van та ін. "Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synuclein." Frontiers in Behavioral Neuroscience 9 (31 березня 2015): 68. https://doi.org/10.3389/fnbeh.2015.00068.

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Parkinson's disease is a neurodegenerative disorder characterized by motor and non-motor disturbances. Various pathogenic pathways drive disease progression including oxidative stress, mitochondrial dysfunction, α-synuclein aggregation and impairment of protein degradation systems. Dysfunction of the ubiquitin-proteasome system in the substantia nigra of Parkinson's disease patients is believed to be one of the causes of protein aggregation and cell death associated with this disorder. Lactacystin, a potent inhibitor of the proteasome, was previously delivered to the nigrostriata

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23

Badawy, Shaymaa Mohamed Mohamed, Taro Okada, Taketoshi Kajimoto та ін. "Extracellular α-synuclein drives sphingosine 1-phosphate receptor subtype 1 out of lipid rafts, leading to impaired inhibitory G-protein signaling". Journal of Biological Chemistry 293, № 21 (2018): 8208–16. http://dx.doi.org/10.1074/jbc.ra118.001986.

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α-Synuclein (α-Syn)-positive intracytoplasmic inclusions, known as Lewy bodies, are thought to be involved in the pathogenesis of Lewy body diseases, such as Parkinson's disease (PD). Although growing evidence suggests that cell-to-cell transmission of α-Syn is associated with the progression of PD and that extracellular α-Syn promotes formation of inclusion bodies, its precise mechanism of action in the extracellular space remains unclear. Here, as indicated by both conventional fractionation techniques and FRET-based protein–protein interaction analysis, we demonstrate that extracellular α-S

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Hara, Susumu, Shigeki Arawaka, Hiroyasu Sato та ін. "Serine 129 phosphorylation of membrane-associated α-synuclein modulates dopamine transporter function in a G protein–coupled receptor kinase–dependent manner". Molecular Biology of the Cell 24, № 11 (2013): 1649–60. http://dx.doi.org/10.1091/mbc.e12-12-0903.

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Most α-synuclein (α-syn) deposited in Lewy bodies, the pathological hallmark of Parkinson disease (PD), is phosphorylated at Ser-129. However, the physiological and pathological roles of this modification are unclear. Here we investigate the effects of Ser-129 phosphorylation on dopamine (DA) uptake in dopaminergic SH-SY5Y cells expressing α-syn. Subcellular fractionation of small interfering RNA (siRNA)–treated cells shows that G protein–coupled receptor kinase 3 (GRK3), GRK5, GRK6, and casein kinase 2 (CK2) contribute to Ser-129 phosphorylation of membrane-associated α-syn, whereas cytosolic

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25

Liu, Peng, Xiaoying Wang, Ning Gao та ін. "G protein-coupled receptor kinase 5, overexpressed in the α-synuclein up-regulation model of Parkinson's disease, regulates bcl-2 expression". Brain Research 1307 (січень 2010): 134–41. http://dx.doi.org/10.1016/j.brainres.2009.10.036.

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Koukouraki, Pelagia, та Epaminondas Doxakis. "Constitutive translation of human α-synuclein is mediated by the 5′-untranslated region". Open Biology 6, № 4 (2016): 160022. http://dx.doi.org/10.1098/rsob.160022.

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Genetic and biochemical studies have established a central role for α-synuclein (SNCA) accumulation in the pathogenesis of Parkinson's disease. Uncovering and subsequently interfering with physiological mechanisms that control SNCA expression is one approach to limit disease progression. To this end, the long and GC-rich 5′-untranslated region (UTR) of SNCA, which is predicted to fold into stable hairpin and G-quadruplex RNA motifs, was investigated for its role in mRNA translation. Inclusion of SNCA 5′-UTR significantly induced expression of both SNCA and luciferase ORF constructs. This effec

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Huang, Zhi-xiang, Jin-hui Tan, Tian-wang Li, et al. "Influence of sinomenine on protein profiles of peripheral blood mononuclear cells from ankylosing spondylitis patients: a pharmacoproteomics study." Chinese Medical Journal 126, no. 19 (2013): 3645–50. http://dx.doi.org/10.3760/cma.j.issn.0366-6999.20131510.

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Background Ankylosing spondylitis (AS) is a common inflammatory rheumatic disease which lacks satisfactory treatment so far. Sinomenine (SIN) is an alkaloid and has recently been utilized in treating multiple rheumatic diseases including AS in China, but its exact mechanism remains to be explored. This study investigated the alteration of proteome in peripheral blood mononuclear cells (PBMCs) from AS patients. Methods Thirty AS patients were enrolled in this study. PBMCs from each AS patient were cultured in medium with or without SIN respectively. Then PBMCs proteins from both groups were sep

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Gao, Wen, Yang Wang, Fuping Lu та Fufeng Liu. "Ultrasound-Assisted Enzymatic Extraction of Polysaccharides from Tricholoma matsutake: Optimization, Structural Characterization, and Inhibition of α-Synuclein Aggregation". Foods 13, № 24 (2024): 4150. https://doi.org/10.3390/foods13244150.

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This study optimized ultrasound-assisted enzymatic (UAE) extraction of TMP (Tricholoma matsutake polysaccharide) through response surface methodology. The optimal conditions included complex enzyme comprising 1.15% cellulase, 0.60% pectinase, and 0.95% dispase, with ultrasound for 24 min at 84.5 °C and enzyme hydrolysis at pH 5.0. This process yielded 19.74 ± 0.51% TMP, exceeding traditional hot water extraction by over four times. Fourier transform infrared spectroscopy (FT–IR) confirmed that UAE did not alter the structure of TMP. In vitro experiments indicated that TMP-UAE demonstrated enha

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Kulkarni, Apoorva M., Shailima Rampogu, and Keun Woo Lee. "Computer-Aided Drug Discovery Identifies Alkaloid Inhibitors of Parkinson’s Disease Associated Protein, Prolyl Oligopeptidase." Evidence-Based Complementary and Alternative Medicine 2021 (April 8, 2021): 1–10. http://dx.doi.org/10.1155/2021/6687572.

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Parkinson’s disease is a common neurodegenerative disorder marked by the accumulation of the protein alpha synuclein. Studies have indicated the role of prolyl oligopeptidase (POP), a serine protease, in alpha synuclein accumulation. Therefore, POP emerges as an attractive medicinal target. Traditionally, most of the early medicines have been plant-based owing to their ready availability and negligible side effects. Alkaloids owing to their neurotransmitter modulatory, anti-amyloid, anti-oxidant, and anti-inflammatory activities have shown potential in neurodegenerative disease. In this work,

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Lin, Yao, Lanfang Tang, Peizhen Huang, et al. "Mechanisms of Cong Rong Shu Jing Compound Effects on Endoplasmic Reticulum Stress in a Rat Model of Parkinson’s Disease." Evidence-Based Complementary and Alternative Medicine 2020 (May 14, 2020): 1–10. http://dx.doi.org/10.1155/2020/1818307.

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This study investigated the effects of the Cong Rong Shu Jing (CRSJ) compound on endoplasmic reticulum stress in a rat model of Parkinson's disease (PD). A total of 40 rats were subcutaneously injected with rotenone-sunflower oil emulsion into the back of the neck to establish a rat model of PD. These PD rats were randomly divided into low-, medium-, and high-dose groups (intragastric administration of 0.5, 1, and 2 g/kg CRSJ, respectively) and a model group (intragastric administration of the solvent; 10 rats per group). Furthermore, 10 rats each were attributed to the control and vehicle gro

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Wischhusen, Jörg, Jingjing Wu, Fadhil Ahsan, et al. "alpha-synuclein peptides presented on chimeric MHC class Ib molecules prevent loss of substantia nigra neurons in an animal model for Parkinson’s disease." Journal of Immunology 208, no. 1_Supplement (2022): 60.16. http://dx.doi.org/10.4049/jimmunol.208.supp.60.16.

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Abstract Aim An accumulating body of evidence suggests the involvement of alpha-synuclein (aSyn) specific autoreactive T cells in Parkinson’s disease (PD). Here, we investigate whether novel antigen-specific tolerance-inducing biomolecules, that present peptide antigens on MHC class Ib-related molecules, can inhibit neurodegeneration and prevent PD in vivo. Methods The alpha3 domain of the human MHC class Ib molecule HLA-G inhibits T cells via the human ILT-2 or the murine PIRB receptor. We fused this HLA-G alpha3 domain to MHC class I alpha1-alpha2 antigen presenting domains, antigenic peptid

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Yang, Ju Hwan, та Eun Sang Choe. "Protein kinase G regulates β-synuclein in response to repeated exposure to cocaine in the rat dorsal striatum in a Ca2+-dependent manner". Neuroscience Letters 582 (жовтень 2014): 6–11. http://dx.doi.org/10.1016/j.neulet.2014.08.042.

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Ochneva, Aleksandra, Yana Zorkina, Olga Abramova, et al. "Protein Misfolding and Aggregation in the Brain: Common Pathogenetic Pathways in Neurodegenerative and Mental Disorders." International Journal of Molecular Sciences 23, no. 22 (2022): 14498. http://dx.doi.org/10.3390/ijms232214498.

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Mental disorders represent common brain diseases characterized by substantial impairments of social and cognitive functions. The neurobiological causes and mechanisms of psychopathologies still have not been definitively determined. Various forms of brain proteinopathies, which include a disruption of protein conformations and the formation of protein aggregates in brain tissues, may be a possible cause behind the development of psychiatric disorders. Proteinopathies are known to be the main cause of neurodegeneration, but much less attention is given to the role of protein impairments in psyc

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Houser, Madelyn C., and Malú G. Tansey. "Regulator of G Protein Signaling 10 is a novel regulator of intestinal inflammation." Journal of Immunology 196, no. 1_Supplement (2016): 207.16. http://dx.doi.org/10.4049/jimmunol.196.supp.207.16.

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Abstract Sustained intestinal inflammation has been implicated in the development and progression of numerous diseases, including neurodegenerative disorders such as Parkinson’s disease (PD). Identifying mechanisms that regulate intestinal immune responses can provide insight into the pathogenesis of these disorders and present new therapeutic targets. Regulator of G protein Signaling 10 (RGS10) is a GTPase-activating protein that alters proinflammatory activity in microglia, macrophages, and T cells and also regulates immune cell chemotaxis. Furthermore, RGS10 is protective in animal models o

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Siddique, Yasir Hasan, Wasi Khan, Braj Raj Singh, and Alim H. Naqvi. "Synthesis of Alginate-Curcumin Nanocomposite and Its Protective Role in Transgenic Drosophila Model of Parkinson’s Disease." ISRN Pharmacology 2013 (September 19, 2013): 1–8. http://dx.doi.org/10.1155/2013/794582.

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The genetic models in Drosophila provide a platform to understand the mechanism associated with degenerative diseases. The model for Parkinson's disease (PD) based on normal human alpha-synuclein (αS) expression was used in the present study. The aggregation of αS in brain leads to the formation of Lewy bodies and selective loss of dopaminergic neurons due to oxidative stress. Polyphenols generally have the reduced oral bioavailability, increased metabolic turnover, and lower permeability through the blood brain barrier. In the present study, the effect of synthesized alginate-curcumin nanocom

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Park, Jun Sung, Riaz Ahmad, Kyonghwan Choe, Min Hwa Kang, Tae Ju Park та Myeong Ok Kim. "Immunization Effects of a Novel α-Synuclein-Based Peptide Epitope Vaccine in Parkinson’s Disease-Associated Pathology". Vaccines 11, № 12 (2023): 1820. http://dx.doi.org/10.3390/vaccines11121820.

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Parkinson’s disease (PD) is a chronic neurodegenerative disease that affects the central nervous system, specifically the motor system. It is mainly caused by the loss of dopamine due to the accumulation of α-synuclein (α-syn) protein in the striatum and substantia nigra pars compacta (SNpc). Previous studies have reported that immunization may be a potential preventive strategy for neurodegenerative diseases such as Alzheimer’s disease (AD) and amyotrophic lateral sclerosis (ALS). Therefore, the aim of the study was to design an α-syn specific epitope vaccine and investigate its effect in PD-

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Wang, Xiao-Wen, Liang-Jie Yuan, Ye Yang, Mei Zhang, and Wen-Fang Chen. "IGF-1 inhibits MPTP/MPP+-induced autophagy on dopaminergic neurons through the IGF-1R/PI3K-Akt-mTOR pathway and GPER." American Journal of Physiology-Endocrinology and Metabolism 319, no. 4 (2020): E734—E743. http://dx.doi.org/10.1152/ajpendo.00071.2020.

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Autophagy dysfunctions are involved in the pathogenesis of Parkinson’s disease (PD). In the present study, we aimed to evaluate the involvement of G protein-coupled estrogen receptor (GPER) in the inhibitory effect of insulin-like growth factor-1 (IGF-1) against excessive autophagy in PD animal and cellular models. 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) treatment significantly induced mouse movement disorder and decreased the protein level of tyrosine hydroxylase (TH) in the substantia nigra (SN) and dopamine (DA) content in striatum. Along with the dopamine neuron injury, we obse

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Simon, Christopher, Tomoko Soga та Ishwar Parhar. "Kisspeptin-10 Mitigates α-Synuclein-Mediated Mitochondrial Apoptosis in SH-SY5Y-Derived Neurons via a Kisspeptin Receptor-Independent Manner". International Journal of Molecular Sciences 24, № 7 (2023): 6056. http://dx.doi.org/10.3390/ijms24076056.

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The hypothalamic neurohormone kisspeptin-10 (KP-10) was inherently implicated in cholinergic pathologies when aberrant fluctuations of expression patterns and receptor densities were discerned in neurodegenerative micromilieus. That said, despite variable degrees of functional redundancy, KP-10, which is biologically governed by its cognate G-protein-coupled receptor, GPR54, attenuated the progressive demise of α-synuclein (α-syn)-rich cholinergic-like neurons. Under explicitly modeled environments, in silico algorithms further rationalized the surface complementarities between KP-10 and α-syn

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Atiq, Abubakar, Hyeon-Jin Lee, Amjad Khan, et al. "Vitamin E Analog Trolox Attenuates MPTP-Induced Parkinson’s Disease in Mice, Mitigating Oxidative Stress, Neuroinflammation, and Motor Impairment." International Journal of Molecular Sciences 24, no. 12 (2023): 9942. http://dx.doi.org/10.3390/ijms24129942.

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Trolox is a potent antioxidant and a water-soluble analog of vitamin E. It has been used in scientific studies to examine oxidative stress and its impact on biological systems. Trolox has been shown to have a neuroprotective effect against ischemia and IL-1β-mediated neurodegeneration. In this study, we investigated the potential protective mechanisms of Trolox against a 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease mouse model. Western blotting, immunofluorescence staining, and ROS/LPO assays were performed to investigate the role of trolox against neuroinfla

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Rehman, Inayat Ur, Amjad Khan, Riaz Ahmad, et al. "Neuroprotective Effects of Nicotinamide against MPTP-Induced Parkinson’s Disease in Mice: Impact on Oxidative Stress, Neuroinflammation, Nrf2/HO-1 and TLR4 Signaling Pathways." Biomedicines 10, no. 11 (2022): 2929. http://dx.doi.org/10.3390/biomedicines10112929.

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Nicotinamide (NAM) is the amide form of niacin and an important precursor of nicotinamide adenine dinucleotide (NAD), which is needed for energy metabolism and cellular functions. Additionally, it has shown neuroprotective properties in several neurodegenerative diseases. Herein, we sought to investigate the potential protective mechanisms of NAM in an intraperitoneal (i.p) 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP)-induced Parkinson’s disease (PD) mouse model (wild-type mice (C57BL/6N), eight weeks old, average body weight 25–30 g). The study had four groups (n = 10 per group): contr

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Zafar, Saima, Aneeqa Noor, Neelam Younas, et al. "SWATH Mass Spectrometry-Based CSF Proteome Profile of GBA-Linked Parkinson’s Disease Patients." International Journal of Molecular Sciences 23, no. 22 (2022): 14166. http://dx.doi.org/10.3390/ijms232214166.

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β-glucocerebrosidase (GBA)-associated mutations are a significant risk factor for Parkinson’s disease (PD) that aggravate the disease pathology by upregulating the deposition of α-Synuclein (α-Syn). The resultant clinical profile varies for PD patients without GBA mutations. The current study aimed to identify the proteomic targets involved in the pathogenic pathways leading to the differential clinical presentation of GBA-associated PD. CSF samples (n = 32) were obtained from PD patients with GBA mutations (n = 22), PD patients without GBA mutations (n = 7), and healthy controls that were car

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Niederberger, Ellen, Annett Wilken-Schmitz, Christine Manderscheid, Yannick Schreiber, Robert Gurke, and Irmgard Tegeder. "Non-Reproducibility of Oral Rotenone as a Model for Parkinson’s Disease in Mice." International Journal of Molecular Sciences 23, no. 20 (2022): 12658. http://dx.doi.org/10.3390/ijms232012658.

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Oral rotenone has been proposed as a model for Parkinson’s disease (PD) in mice. To establish the model in our lab and study complex behavior we followed a published treatment regimen. C57BL/6 mice received 30 mg/kg body weight of rotenone once daily via oral administration for 4 and 8 weeks. Motor functions were assessed by RotaRod running. Immunofluorescence studies were used to analyze the morphology of dopaminergic neurons, the expression of alpha-Synuclein (α-Syn), and inflammatory gliosis or infiltration in the substantia nigra. Rotenone-treated mice did not gain body weight during treat

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Wu, Weiwei, Chun Chau Sung, Peichun Yu, Jiahua Li, and Kenny K. K. Chung. "S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease." PLOS ONE 15, no. 4 (2020): e0232019. http://dx.doi.org/10.1371/journal.pone.0232019.

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Rogers, Edmond, Timothy Beauclair, Guenter Gross, and Riyi Shi. "95923 TBI-on-a-chip: Linking physical impact to neurodegeneration by decrypting primary and secondary injury mechanisms." Journal of Clinical and Translational Science 5, s1 (2021): 91. http://dx.doi.org/10.1017/cts.2021.636.

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ABSTRACT IMPACT: This unique approach has the capability to elucidate the pathological mechanisms underlying traumatic brain injuries and neurodegeneration, both separately and in concert, while simultaneously providing a semi-high throughput model for investigating potential pharmaceutical interventions: discoveries that would have major translational implications and a significant impact worldwide. OBJECTIVES/GOALS: We aim to improve our understanding of the mechanisms behind the development of neurodegenerative diseases by utilizing the link between traumatic brain injuries and demonstrated

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Albanese, Federica, Chiara Domenicale, Mattia Volta, and Michele Morari. "Modeling Parkinson's disease in LRRK2 mice: focus on synaptic dysfunction and the autophagy-lysosomal pathway." Biochemical Society Transactions 50, no. 1 (2022): 621–32. http://dx.doi.org/10.1042/bst20211288.

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Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene are associated with familial and sporadic forms of Parkinson's disease (PD), for which the LRRK2 locus itself represents a risk factor. Idiopathic and LRRK2-related PD share the main clinical and neuropathological features, thus animals harboring the most common LRRK2 mutations, i.e. G2019S and R1441C/G, have been generated to replicate the parkinsonian phenotype and investigate the underlying pathological mechanisms. Most LRRK2 rodent models, however, fail to show the main neuropathological hallmarks of the disease i.e. the degenerati

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Wu, Weiwei, Chun Chau Sung, Peichun Yu, Jiahua Li, and Kenny K. K. Chung. "Correction: S-Nitrosylation of G protein-coupled receptor kinase 6 and Casein kinase 2 alpha modulates their kinase activity toward alpha-synuclein phosphorylation in an animal model of Parkinson’s disease." PLOS ONE 15, no. 6 (2020): e0235296. http://dx.doi.org/10.1371/journal.pone.0235296.

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Vlcek, Bianca, Sylvie Dumas, Sara Ekmark-Lewén, Eleonora Rubino, Martin Ingelsson та Åsa Wallén-Mackenzie. "Aldh1a1 and additional markers of dopamine cell heterogeneity in substantia nigra and ventral tegmental area identified as preserved in two transgenic α-synuclein mouse models of neurodegenerative disease". Exploration of Neuroprotective Therapy 3, № 5 (2023): 299–327. http://dx.doi.org/10.37349/ent.2023.00053.

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Aim: Parkinson’s disease (PD) is characterized by degeneration of midbrain dopamine neurons and synucleinopathy [aggregated alpha-synuclein protein (αSyn)]. The correlation between αSyn pathology and dopamine neuron degeneration remains to be fully established. Mouse models of PD are commonly used to increase knowledge of disease mechanisms. Lately, midbrain dopamine neurons have gained attention as more heterogeneous than previously recognized. With the aim to determine how the midbrain dopamine system in mice is affected in the presence of αSyn pathology, this brain system was studied in two

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Gruschus, James. "Coevolution study of tau and a-synuclein suggests a connection between their normal interaction in neurons and the Parkinson's disease-associated mutation A53T." Medical Research Archives 9, no. 7 (2021). http://dx.doi.org/10.18103/mra.v9i7.2497.

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Alpha-synuclein lies at the center of Parkinson’s disease etiology, and polymorphisms in the gene for the microtubule-associated protein tau are risk factors for getting the disease. Tau and a-synuclein interact in vitro, and a-synuclein can also compete with tau binding to microtubules. To test whether these interactions might be part of their natural biological functions, a correlated mutation analysis was performed between tau and a-synuclein, looking for evidence of coevolution. For comparison, analyses were also performed between tau and b- and g-synuclein. In addition, analyses were perf

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Winer, Joseph R., Melanie J. Plastini, America Romero та ін. "Effects of α‐synuclein pathology in Alzheimer’s disease and normal aging". Alzheimer's & Dementia 20, S8 (2024). https://doi.org/10.1002/alz.095792.

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AbstractBackgroundα‐Synuclein is the hallmark pathology of Parkinson’s disease and dementia with Lewy bodies, described together as Lewy body disease (LBD). α‐Synuclein is also commonly observed in the context of Alzheimer’s disease (AD). Here we investigate the frequency of α‐synuclein positivity in an AD research cohort and clinically unimpaired individuals (CU), as well as associations with demographics and AD biomarkers.MethodWe assessed α‐synuclein status (αSyn±) in 69 clinically diagnosed AD (38 mild cognitive impairment and 31 dementia) and 277 CU using a cerebrospinal fluid α‐synuclein

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Matsuo, Kazuya, Sefan Asamitsu, Kohei Maeda та ін. "RNA G-quadruplexes form scaffolds that promote neuropathological α-synuclein aggregation". Cell, жовтень 2024. http://dx.doi.org/10.1016/j.cell.2024.09.037.

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