To see the other types of publications on this topic, follow the link: Gen (langue).
Dissertations / Theses on the topic 'Gen (langue)'
Create a spot-on reference in APA, MLA, Chicago, Harvard, and other styles
Consult the top 50 dissertations / theses for your research on the topic 'Gen (langue).'
Next to every source in the list of references, there is an 'Add to bibliography' button. Press on it, and we will generate automatically the bibliographic reference to the chosen work in the citation style you need: APA, MLA, Harvard, Chicago, Vancouver, etc.
You can also download the full text of the academic publication as pdf and read online its abstract whenever available in the metadata.
Browse dissertations / theses on a wide variety of disciplines and organise your bibliography correctly.
1
Mensah, Barnabé. "La modernisation du Gὲngbe." Paris, INALCO, 2008. http://www.theses.fr/2008INAL0025.
Full textAbstract:
Peut-on se servir d'une langue africaine comme le gὲngbe pour enseigner les sciences et la technologie modernes? A cette question, certains répondent par la négative prétextant que les langues africaines sont trop pauvres en vocabulaire de spécialité et inaptes à l'enseignement de ces disciplines. Dans ce travail, l'auteur s'inscrit en faux contre ce préjugé. Après avoir effectué une étude sociolinguistique de la langue, il conclut que pour servir de véhicule à l'enseignement des sciences et de la technologie modernes, le gὲngbe doit se doter à la fois d'une orthographe stable et normée puis d'un lexique enrichi. La thèse comprend donc deux grandes parties. Une première consacrée à la modernisation de l'orthographe et une deuxième à celle du lexique où l'auteur démontre que le gὲngbe dispose suffisamment de ressources susceptibles de l'aider à dire toutes les innovation techniques et scientifiquesCan an African language such as Gὲngbe be used for teaching science and modern technology? Some say no, arguing that African languages are too poor in specialist vocabulary and therefore unfit for teaching these subjects. In this work, the author challenges such a prejudice. After a sociolinguistic survey of the language, he concludes that in order to serve as a vehicle for teaching science and modern technology, Gὲngbe must develop a standardised orthography and enrich its lexicon. The thesis is therefore divided into two parts. The first part deals with orthography and the second with the lexicon where the author shows that Gὲngbe does indeed have sufficient resources at its disposal to articulate any and all technological and scientific terminology
2
Kwok, Kar-ling Florence. "Form and function of conjunction gen1 zyu6 (gen zhu) in story telling of Cantonese speaking children." Click to view the E-thesis via HKU Scholars Hub, 2007. http://lookup.lib.hku.hk/lookup/bib/B42005231.
Full textAbstract:
Thesis (B.Sc)--University of Hong Kong, 2007."A dissertation submitted in partial fulfilment of the requirements for the Bachelor of Science (Speech and Hearing Sciences), The University of Hong Kong, June 30, 2007." Includes bibliographical references (p. 28-30). Also available in print.
3
Ljiljana, Šašić Zorić. "Молекуларни диверзитет Merodon aureus групе (Diptera: Syrphidae)." Phd thesis, Univerzitet u Novom Sadu, Prirodno-matematički fakultet u Novom Sadu, 2018. https://www.cris.uns.ac.rs/record.jsf?recordId=107246&source=NDLTD&language=en.
Full textAbstract:
Род Merodon Meigen (Diptera: Syrphidae) се одликује великм бројем врста које имају функцију у опрашивању биљака. У оквиру овог рода својом разноврсношћу издваја се Merodon aureus група врста коју поред фенотипски различитих одликује и присуство већег броја криптичних врста. Због морфолошке сличности криптичне врсте представљају изазов за таксономе, те су молекуларне методе од посебног значаја. У том светлу примарни циљ овог истраживања је био утврђивање молекуларног диверзитета групе и могућности његове примене у таксономији. Истраживање је било засновано на анализи варијабилности секвенци COI и 28S рРНК гена за 718 јединки 41 описане или новоткривене врсте сирфида. Додатно, тестирана је примењивост мултилокусних ISSR маркера у раздвајању врста M. luteomaculatus комплекса. Узорци су тестирани и на присуство Wolbachia с обзиром да она може утицати на еволуцију митохондријалних гена. Добијени резултати су указали на високу варијабилност секвенци COI гена који се показао корисним у утврђивању граница криптичних врста у анализираним комплексима. Секвенце 28Ѕ рРНК гена у већини случајева нису биле од већег значаја за раздвајање врста, али би могле имати потенцијал у раздвајању комплекса или подгрупа врста као допуна анализи секвенци COI гена. Додатно, ISSR маркери су показали потенцијал за примену у молекуларној таксономији. Све анализиране врсте изузев М. balkanicus су биле заражене Wolbachia, али није утврђена јасна веза између варијабилности секвенци митохондријалног COI гена и инфекционог статуса врста. Утврђен образац генетичке варијабилности је вероватно обликован драстичним климатским променама током Плеистоцена и фрагментацијом хабитата. Да би се донели крајњи закључци о таксономском статусу предложених врста потребно је добијене резултате интегрисати са подацима других релевантних научних дисциплина.Rod Merodon Meigen (Diptera: Syrphidae) se odlikuje velikm brojem vrsta koje imaju funkciju u oprašivanju biljaka. U okviru ovog roda svojom raznovrsnošću izdvaja se Merodon aureus grupa vrsta koju pored fenotipski različitih odlikuje i prisustvo većeg broja kriptičnih vrsta. Zbog morfološke sličnosti kriptične vrste predstavljaju izazov za taksonome, te su molekularne metode od posebnog značaja. U tom svetlu primarni cilj ovog istraživanja je bio utvrđivanje molekularnog diverziteta grupe i mogućnosti njegove primene u taksonomiji. Istraživanje je bilo zasnovano na analizi varijabilnosti sekvenci COI i 28S rRNK gena za 718 jedinki 41 opisane ili novotkrivene vrste sirfida. Dodatno, testirana je primenjivost multilokusnih ISSR markera u razdvajanju vrsta M. luteomaculatus kompleksa. Uzorci su testirani i na prisustvo Wolbachia s obzirom da ona može uticati na evoluciju mitohondrijalnih gena. Dobijeni rezultati su ukazali na visoku varijabilnost sekvenci COI gena koji se pokazao korisnim u utvrđivanju granica kriptičnih vrsta u analiziranim kompleksima. Sekvence 28Ѕ rRNK gena u većini slučajeva nisu bile od većeg značaja za razdvajanje vrsta, ali bi mogle imati potencijal u razdvajanju kompleksa ili podgrupa vrsta kao dopuna analizi sekvenci COI gena. Dodatno, ISSR markeri su pokazali potencijal za primenu u molekularnoj taksonomiji. Sve analizirane vrste izuzev M. balkanicus su bile zaražene Wolbachia, ali nije utvrđena jasna veza između varijabilnosti sekvenci mitohondrijalnog COI gena i infekcionog statusa vrsta. Utvrđen obrazac genetičke varijabilnosti je verovatno oblikovan drastičnim klimatskim promenama tokom Pleistocena i fragmentacijom habitata. Da bi se doneli krajnji zaključci o taksonomskom statusu predloženih vrsta potrebno je dobijene rezultate integrisati sa podacima drugih relevantnih naučnih disciplina.
Genus Merodon Meigen (Diptera: Syrphidae) is characterized by a large number of species which have a function in plants pollination. Within this genus, Merodon aureus species group is distinguished by its diversity and it is characterized not only by phenotypically divergent species but also with a large number of cryptic species. Because of the high morphological similarity, cryptic species are a challenge for taxonomist, thus molecular methods are of special importance. The primary goal of this research was to determine the molecular diversity of the group and the possibility of its application in taxonomy. The study was based on the sequences variability analysis of COI and 28S rRNA genes for 718 individuals belonging to 41 described or newly discovered hoverfly species. Additionally, the applicability in species delimitation of multilocus marker ISSR was tested on M. luteomaculatus species complex. Specimens have also been tested for Wolbachia since it may affect the evolution of mitochondrial genes. The obtained results indicated a high variability of the COI gene sequences that proved useful for determining the cryptic species boundaries in the analyzed complexes. Sequences of the 28S rRNA gene in most cases were not of much significance for the species delimitation, but they could have the potential to separate species complexes оr subgroups as a complement to the analysis of the COI gene sequences. Additionally, the ISSR markers showed potential for application in molecular taxonomy. All analyzed species except M. balkanicus were infected with Wolbachia, but no clear relation was established between the sequence variability of the mitochondrial COI gene and the infectious status of species. The established pattern of genetic variability is probably shaped by drastic climatic changes during Pleistocene and habitats fragmentation. In order to achieve the final conclusions on the taxonomic status of the proposed species, it is necessary to integrate the obtained results with the data of other relevant scientific disciplines.
4
Eichhorn, Pieter Johan Adam. "Towards the cloning of the Cornelia de Lange syndrome gene." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.327219.
Full text
5
Smith, Melanie Jane. "Towards positional cloning of a Cornelia de Lange syndrome gene at 3q26.3." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.311133.
Full text
6
Cuddihy, Paul. "Compiling GEN-X knowledge bases into "C" /." Online version of thesis, 1991. http://hdl.handle.net/1850/10792.
Full text
7
Imamwerdi, Burhan. "Towards the positional cloning of the Cornelia de Lange syndrome gene at chromosome 3q26.3." Thesis, University of Newcastle Upon Tyne, 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.313218.
Full text
8
Sagart, Laurent. "Phonétique et phonologie d'un groupe de dialectes chinois : les dialectes Gan." Aix-Marseille 1, 1990. http://www.theses.fr/1990AIX10006.
Full textAbstract:
La formation des dialectes gan reflete le processus de peuplement du jiangxi par des populations chinoises originaires du nord de la chine a differentes epoques. La phonetique, la phonologie, et dans une certaine mesure, le lexique de deux dialectes gan, shanggao et wuning, sont decrits et analyses; la stratification chronologique des dialectes du jiangxi est etudiee dans le dialecte de la capitale provinciale, nanchang. Enfin, quelques-uns des principaux changements phonetiques affectant les consonnes initiales sont etudies dans une perspective geographique.
9
Langer, David [Verfasser]. "Kaiso und CTCF regulieren geprägte Gene in cis und in trans / David Langer." Mainz : Universitätsbibliothek Mainz, 2015. http://d-nb.info/1064721435/34.
Full text
10
Borislav, Simendić. "Niskotemperaturno procesiranje sol-gel mulita." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2003. https://www.cris.uns.ac.rs/record.jsf?recordId=71471&source=NDLTD&language=en.
Full textAbstract:
Apstrakt je obrađen tehnologijama za optičko prepoznavanje teksta (OCR).Mehanizam nastanka mulita zavisi od načina doziranja polaznih oblika reaktanata kao što su alumina i silika. Dobijanje mulita sol-gel postupkom je u velikoj meri poboljšano u odnosu na klasično procesiranje zbog mogućnosti homogenog mešanja AI2O3 i SiO2 komponenti i kontrole dodataka. Sol-gel metod omogućuje pripremu vrlo homogenih i reaktivnih gelova koji mogu da sinteruju na nižim temperaturama pri čemu se može postići vrlo fina mikrostruktura. U ovom radu koji se odnosio na procesiranje mulita sol-gel postupkom, hipoteza je bila da se na samom početku procesiranja aluminijumovi joni iz alkoholnog rastvora Al-soli uključuju u polimernu gel strukturu koju formira silika. Svrha ovog rada, je proučavanje uticaja procesnih promenjivih, dodatka fluornog jona i “seedinga” na temperaturu nastanka sol-gel mulita pri čemu se očekuje što je moguće niža tempertura nastanka mulita (niža od 9800C). Polimerni sol je dobijen u prvom slučaju mešanjem TEOS-a i aluminijum nitrata nanohidrata koji je prethodno rastvoren u etil alkoholu. U drugom slučaju, u polimerni sol je dodavan fluorni jon u koncentraciji 2 do 5 % mas. u odnosu na očekivani prinos mulita i u trećem slučaju je dodavana različita količina mulitnih klica (2-4 % mas.). Eksperimantalno je potvrđeno da procesne promenljive; pH, temperatura geliranja i R odnos imaju, veliki uticaj na brzinu geliranja i na nastanak mulita. U slučaju dodavanja fluornog jona, potvrdena je hipoteza da fluorni jona na različite načine utiče na mehanizam nastanka mulita, pri čemu u prvom slučaju prisustvo fluornog jona obezbeduje mesta u oblastima razdvajanja granica faza nakon geliranja koja utiču na proces nukleacije. Ova mesta slično procesu kristalizacije stakla, omogućuju lakšu nukleaciju mulita prilikom njegove transformacije iz gela. Mesta na granici razdvanja faza postaju mesta na kojima se uspostavlja proces heterogene nukleacije što je jedan od mogućih načina za snižavanje temperature nastanka mulita. Pored ovoga, dodavanje fluornog jona je doprinelo promeni mulitnih gel struktura, pri čemu je promena brzine hidrolize silike imala za posledicu promenu sadržaja vezane vode u toku geliranja što se takođe značajno odražavalo na temperaturu nastanka mulita. Eksperimentalni rezultati termički obradenih gelova su pokazali, da dodavanje lluornog jona u polimerni mulitni sol stvara uslove za snižavanje temperature obrazovanja mulita sve do 8900C. U ovom radu je takođe pokazano da mulitne čestice, kao nukleanti pri “seeding" procesiranju, doprinose nastanku mulitnog gela koji nakon termičke obrade na 10000C pokazuje veoma finu mikrostrukturu.Abstract was processed by technology for Optical character recognition (OCR).The mechanism of mullite formation depends upon the method of combining the alumina and silica containing reactants. Mullite can be obtained through the sol-gel process and can be greatly improved by the control of some reaction conditions particulaiiy by homogeneous mixing of Al2O3 and SiO2, and controlling of the additions. Sol-gel method allow preparation of very homogenous and reactive gels which can be sintering at low temperature and consequently submicronic microstructure can be reached. In this study of the mullite formation by sol-gel method, the hypothesis was that aluminium ions from alcoholic solulion of its salts incorporate to polymeric silica gel structure. The aim of this work was the investigation of the effect processing variables, fluorine addition and “seeding”on the temperature of sol-gel mullite formation and to obtain as lower temperature of mullite formation as possible (smaller than 980°C). Polymeric sols, were prepared by the mixing of TEOS and aluminum nitrate nanohydrate dissolved in absolute ethyl alcohol and by adding fluorine ions in the second case from 2 wt.% to 5 wt.% and by different content of mullite seeded (2- 4 wt. %). Experimentally is determined that the processing variables as pH, gelling temperature and R ratio have high influence on the gelling rate and mullite formation. The hypothesis in the case of fluorine addition was that addition of fluorine ions could have different effects on the mechanism of mullite formation; the first it makes the sites at boundary of phase separation regions after gelling which influence at the process of the nucleation. These sites will act as a place for easy mullite nucleation, similar to process of the glass crystallization. The boundaries of the phase separation are the sites for heterogeneous nucleation which is one of the condition for lowering the temperature of mullite formation. Besides, fluorine addition could change the mullite gel structure (by changing the rate of hydrolyses of silica and it could change the content of bonded water during gelling), which should be very important for the temperature of mullite formation, too. The experimental results of heat treated gels showed that the addition of fluorine ion does decrease the temperature of mullite formation (in respect to classical sol-gel mullite processing) up to 8900C. As a nucleant in this study the mullite powder by “seeding” process contribute to muillite gel formation that after heat treatment up to 10000C showed very fine microstructure.
11
Boukri, Sarah. "Les motivations d'adhésion du Maroc à l'espace géoculturel francophone." Thesis, Lyon 3, 2014. http://www.theses.fr/2014LYO30036/document.
Full textAbstract:
Depuis la dissolution des deux blocs de la guerre froide, la mondialisation est apparue comme un phénomène incontestable en perpétuelle extension. L’évolution de cette mondialisation vers la sphère culturelle a été la source de nombreux problèmes. C’est dans cette optique, et de la même façon que des espaces géoéconomiques ont vu le jour afin de faciliter et d’harmoniser les échanges commerciaux entre différents pays, ou que des espaces géopolitiques ont été créés dans la perspective d’assurer une coexistence paisible entre les États, que le concept d’unions géoculturelles est né, ces unions devant constituer des espaces dédiés au troisième dialogue : celui des cultures. Afin de schématiser cette relation entre les États et les unions géoculturelles, nous avons pris le cas des relations du Maroc avec l’espace géoculturel Francophone. La Francophonie est une union qui se démarque par son refus de l’actuelle mondialisation et qui prône une mondialisation plus humaniste, respectueuse des peuples et de leurs différences. Le Maroc, pays pourvu d’une composante identitaire et linguistique particulière, a rejoint la Francophonie en 1981. Depuis, la relation entre le Royaume et la Francophonie n’a cessé d’évoluer, néanmoins elle suscite de nombreuses interrogationsSince the Cold War bipolar dissolution, globalization has emerged as an incontestable, ever-expanding phenomenon. The evolution of globalization towards the cultural sphere has caused several issues. As geo-economic spheres have emerged in order to facilitate and harmonize commercial exchanges between countries; and as geopolitical spheres have been created with the view to ensure a peaceful coexistence between States – so in the same fashion has the concept of geo-cultural unions been birthed, with the vision to create spaces dedicated to the third dialogue, that of cultures. In order to illustrate this relationship between States and geo-cultural unions, we have studied the case of the relations between Morocco and the Francophone geo-cultural sphere. The Francophone world is a union that sets itself apart by its refusal of the current globalization and that promotes a more humanistic globalization, respectful of people groups and their differences. Since Morocco, a country laden with a very specific identity and a linguistic singularity, joined the Francophone union in 1981, the relationship between the Kingdom and the Francophone union has constantly evolved. It however gives birth to many interrogations
12
Lange, Sebastian [Verfasser], and Ulrich [Akademischer Betreuer] Lauer. "Evaluation of a novel, suicide gene-armed measles vaccine virus for the treatment of cholangiocarcinoma / Sebastian Lange ; Betreuer: Ulrich Lauer." Tübingen : Universitätsbibliothek Tübingen, 2017. http://d-nb.info/1165506416/34.
Full text
13
Lima, Renata de. "Estudo do gene SHOX em casos de discondrosteose de Léri Weill e displasia mesomélica de Langer." [s.n.], 2010. http://repositorio.unicamp.br/jspui/handle/REPOSIP/310678.
Full textAbstract:
Orientadores: Andréa Trevas Maciel Guerra, Maricilda Palandi de MelloTese (doutorado) - Universidade Estadual de Campinas. Faculdade de Ciencias Medicas
Made available in DSpace on 2018-08-16T03:18:52Z (GMT). No. of bitstreams: 1 Lima_Renatade_D.pdf: 4015661 bytes, checksum: e48a1ea1afcdb807a4d9186f4bb5777c (MD5) Previous issue date: 2010
Resumo: A Discondrosteose de Leri-Weill (DLW), caracterizada por baixa estatura, encurtamento mesomélico dos membros e deformidade de Madelung, deve-se a alterações no gene SHOX, localizado na região pseudoautossômica dos cromossomos sexuais e que atua como fator de transcrição. Alterações em um dos alelos são encontradas em casos de baixa estatura com ou sem DLW, e em ambos os alelos na Displasia Mesomélica de Langer (DML), na qual há alterações esqueléticas mais graves. Há variação fenotípica na DLW, atribuída ao envolvimento de outros genes ou a alterações nas regiões reguladoras à jusante ao gene. No presente estudo, realizou-se a investigação do gene SHOX de 10 pacientes com DLW e um com DML por meio de análises de microssatélites, PCR em tempo real, análise de MLPA e sequenciamento direto. Essas análises permitiram confirmar a etiologia genética do quadro apresentado por sete pacientes, dos quais três apresentavam deleção total ou parcial de um dos alelos. Em um destes pacientes a clinica foi associada a mutação de ponto (IVS3+21G>A no íntron 3), outro paciente (DML) a deleção dos dois alelos, outros pacientes (DLW) a deleção na região downstream do gene, outros dois mutações de ponto (c.439C>A no éxon 3 e c.523delC no éxon 4), outro a deleção (c.523delC) associada a mutação na região 5'UTR. Quatro outros pacientes apresentaram alterações de patogenicidade ainda indefinida: mutações não descritas na região 5'UTR, que poderia interferir no processo de tradução do gene (dois casos), e deleção das regiões referentes às sondas 8, 10 e 12 na análise de MLPA (um caso) e outro caso com relação à deleção da sonda SHOX reg. Os resultados mostram a grande heterogeneidade alélica associada à DLW e indicam a necessidade de que a investigação molecular nesses casos seja ampla, permitindo um diagnóstico molecular mais preciso.
Abstract: Leri-Weill Dyschondrosteosis (LWD) is characterized by short stature, mesomelic shortening of members and Madelung deformity. It results from changes in the SHOX gene, located in the pseudoautosomal region of the sex chromosomes. The protein it codes acts as a transcription factor. Changes in one SHOX allele are found in cases of short stature with or without LWD, whereas Langer Mesomelic Dysplasia (LMD), in which more serious skeletal disorders occur, results from alterations in both alleles. There is phenotypic heterogeneity in LWD, attributed to the possible involvement of other genes, or to changes in regulatory regions downstream of the gene. In the present study, the SHOX gene and the chromosomal SHOX gene region were evaluated in 11 patients with LWD and LMD by using microsatellite PCR, real time PCR analysis, MLPA analysis, and direct sequencing. Those tests confirmed the genetic etiology of the clinical characteristics in seven patients. Three of them carried alleles bearing a partial or total deletion of the SHOX gene, one of which bearing a mutation located in intron 3 (IVS3+21G>A) that has not been described previously; the patient with LMD carried SHOX gene deletion in both alleles; and another had a deletion in the dpwnstream region of the gene. Two patients bore mutations that have not been described previously in exons 3 (C.4390A, Arg147Ser) and 4 (c.523delC, Gln175Lisfs44x219). The later was also associated with a mutation in 5'UTR. Four other patients showed nucleotide changes and deletions of undefined pathogenicity: novel mutations in the 5'UTR, which might interfere with the translation process of the gene (two cases), and deletion of regions related to the probes 8, 10 and 12 in the MLPA analysis (one case) and deletion oh probe SHOX reg. Results showed great molecular heterogeneity associated with LWD, and pointed out the need of a more detailed research to allow more accurate molecular diagnosis.
Doutorado
Ciencias Biomedicas
Doutor em Ciências Médicas
14
Vladimir, Srdić. "Dizajniranje mikrostrukture alumina-cirkonia kompozita dobijenog sol-gel metodom." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 1995. https://www.cris.uns.ac.rs/record.jsf?recordId=71430&source=NDLTD&language=en.
Full textAbstract:
Apstrakt je obrađen tehnologijama za optičko prepoznavanje teksta (OCR).Dobro je poznato da se žilavost keramičkih matrica znatno može povećati sa cirkonia česticama iz razloga što se transformacijom tetragonalne u monokliničnu fazu cirkonie znatna količina energije može apsorbovati, a koja bi inače bila pukotini na raspolaganju za njeno napredovanje.U ovom radu je primenom različitih varijanti sol-gel procesiranja menjana priroda i skala veličine polaznih alumina i cirkonia čestica u cilju dizajniranja mikrostrukture alumina-cirkonia kompozita. Ukazano je na postojanje interakcije između cirkonie i alumine, što je i pored širokog proučavanja alumina-cirkonia kompozita skoro nepoznata pojava. Pokazano je takođe da stepen interakcije zavisi od prirode i veličine polaznih čestica, pri čemu je najveći kod alkoksidnih matričnih kompozita sa cirkoniom dodanom u obliku veoma finih sol čestica ili cirkonjjumovih soli (na primer cirkoniju oksihlorid), a najmanji kod čestičnih matričnih kompozita kod kojih su koriščene guste čestice (alumine-cirkonie).Potvrđeno je da stepe interakcije određuje mikrostrukturni razvoj kompozita u toku zagrevanja. Uticaj interakcije na mikrostrukturni razvoj alumina-cirkonia kompozita je praćen različitim metodama karakterizacije (merenje gustine, IR spektroskopija, rentgenska difrakcija, diferencijalno termijska analiza i skening elektronska mikroskopija). Posle finalnog sinterovanja i bez toplog presovanja su dostignute gustine bliske teorijskim, a postignute mehaničke osobine merene su tvrdoća i žilavost) su razmatrane u funkciji mikorstrukturnih parametara. Utvrđeno je da je dominantan mehanizam povećanja žilavosti naponom indukovano povećanje žilavosti, a maksimalno postignuta vrednost odnosa povećanja žilavosti prema žilavosti matrice iznosi Ks/Ko = 0.69 (što odgovara vrednosti kritičnog faktora intenziteta napona od Kc=5.4 MPa m1/2). Na kraju treba još istaći da eksperimentalno dobijene vrednosti žilavosti dobro fituju izvedenu zavisnost doprinosa transformacionog povećanja žilavosti od veličine tetragonalni cirkonia čestica.Abstract was processed by technology for Optical character recognition (OCR).It is already known that fracture toughness of the ceramic matrices could be increased by dispersing of zirconia particles. The role of zirconia is in the absorption of a substantial amount of energy, which could be consumed by crack advansing, with the transformation from tetragonal to monoclinic simetry.In the presented study the microstructure of the alumina-zirconia composites were designed by changing the nature and the size of original alumina and zirconia panicles, by using a different types of the sol-gel processing methods. It is pointed out on the mutual interaction between zirconia and alumina, which is almost unknown phenomena inspite of very intensive investigation of the alumina-zirconia composite system. The mutual interaction depends on the nature and size of the original particles. The largest interaction exists in alkoxide matrix composites with zirconia added in a form of very fine so! particles or zirconijum-salts (zirconium-oxychloride), and the smallest in the particulate matrix composites with dense panicles (alumina or zirconia). It is confirmed that interaction between zirconia and alumina determine the microstructure development of the heat treated composite samples. The influence of the interaction on the microstructure development was characterised by different method: density measurement, IR spectroscopy. X-ray diffraction, differential thermal analysis and scanning electron microscopy. After final sintering without hot pressing the density reach very high values (in some case >99 % theoretical density). Mechanical properties (hardnes and fracture toughness) were studied in the function of the microstructural parameters. It was shown that the stress induced transformation toughening is a dominant mechanism in the sol-gel processed composites (with zirconia partcles less than critical size)., and the maximal value of the AKc/Ko = 0.69 corresponds to the fracture toughness of Kc = 5.4 MPa m1/2. Experimental fracture toughness data fit the analytically derived functional dependent between fracture toughness and zirconia particle sizes.
15
Zorana, Srećkov. "Наслеђивање садржаја уља у зрну хибрида кукуруза зубана, полузубана и тврдунаца." Phd thesis, Univerzitet u Novom Sadu, Poljoprivredni fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=90372&source=NDLTD&language=en.
Full textAbstract:
У раду је проучаван начин наслеђивања приноса зрна и морфолошких својстава биљке и клипа, као и садржај уља у зрну, у две групе хибрида које су настале укрштањем две инбред линије са повећаним садржајем уља у зрну (1109/IV НС и 1039/IV НС) и шест тестера (НС 27/18, 568/II НС, 922 НС, 15 А НС, А-1 и А-729-5). У наслеђивању приноса зрна по биљци, компонентни приноса и морфолошких својстава, главну улогу има доминантан ефекат гена. У наслеђивању садржаја уља у зрну једино је код хибрида 1109/IV НС x 568/II НС, у обе године проучавања установљен значајнији ефекат адитивних гена. Утврђено је и значајно присуство неповољне интеракције између доминантних гена. За масу 1000 зрна код четири хибрида (1039/IV НС x НС 27/18, 1039/IV НС x 568/II НС, 1039/IV НС x НС 15 А и 1039/IV НС x А-1), као и за висину биљке и клипа код 1039/IV НС x НС 15 А, односно за висину биљке код 1039/IV x 568/II НС установљена је интеракција условљена комплементарним деловањем гена. У раду је одређења херитабилност у ужем, односно ширем смислу. За принос зрна по биљци установљене су средње вредности херитабилности у ширем смислу, и ниске и средње вредности херитабилности у ужем смислу, док су за остала проучавана својства установљене средње и високе вредности херитабилности у ширем смислу, и средње вредности херитабилности у ужем смислу.U radu je proučavan način nasleđivanja prinosa zrna i morfoloških svojstava biljke i klipa, kao i sadržaj ulja u zrnu, u dve grupe hibrida koje su nastale ukrštanjem dve inbred linije sa povećanim sadržajem ulja u zrnu (1109/IV NS i 1039/IV NS) i šest testera (NS 27/18, 568/II NS, 922 NS, 15 A NS, A-1 i A-729-5). U nasleđivanju prinosa zrna po biljci, komponentni prinosa i morfoloških svojstava, glavnu ulogu ima dominantan efekat gena. U nasleđivanju sadržaja ulja u zrnu jedino je kod hibrida 1109/IV NS x 568/II NS, u obe godine proučavanja ustanovljen značajniji efekat aditivnih gena. Utvrđeno je i značajno prisustvo nepovoljne interakcije između dominantnih gena. Za masu 1000 zrna kod četiri hibrida (1039/IV NS x NS 27/18, 1039/IV NS x 568/II NS, 1039/IV NS x NS 15 A i 1039/IV NS x A-1), kao i za visinu biljke i klipa kod 1039/IV NS x NS 15 A, odnosno za visinu biljke kod 1039/IV x 568/II NS ustanovljena je interakcija uslovljena komplementarnim delovanjem gena. U radu je određenja heritabilnost u užem, odnosno širem smislu. Za prinos zrna po biljci ustanovljene su srednje vrednosti heritabilnosti u širem smislu, i niske i srednje vrednosti heritabilnosti u užem smislu, dok su za ostala proučavana svojstva ustanovljene srednje i visoke vrednosti heritabilnosti u širem smislu, i srednje vrednosti heritabilnosti u užem smislu.
In the present study, a mode of inheritance of grain yield, plant and ear morphological traits, as well as kernel oil content was observed in two groups of test-crosses, made by crossing two inbred lines with high oil content (1109/IV NS and 1039/IV NS) and six testers (NS 27/18, 568/II NS, 922 NS, 15 A NS, A-1 i A-729-5). The dominance gene effects for grain yield and morphological traits of plant and ear were more important than additive gene effects. For kernel oil content dominance was more important for almost all studied test-crosses. Additive gene effect was more important than dominance only for hybrid 1109/IV NS x 568/II NS. A significant presence of duplicate type of epistasis was determined. Besides of duplicate epistasis complementary type of epistasis was detected at four hybrids (1039/IV NS x NS 27/18, 1039/IV NS x 568/II NS, 1039/IV NS x NS 15 A, 1039/IV NS x A-1) for 1000-kernel weight. Also this type of epistasis was detected for plant and ear height at 1039/IV NS x NS 15 A, and for plant height at 1039/IV NS x 568/II NS. In the present study broad- and narrow-sense heritability have been evaluated. Medium broad-sence heritability, and low and medium narrow-sence heritability was detected for grain yield per plant, while for the other medium and high broad-sence heritability, as well as medium narrow-sence heritability have been determined.
16
Nataša, Ljubičić. "Генски системи наслеђивањау укрштањима пшенице." Phd thesis, Univerzitet u Novom Sadu, Poljoprivredni fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=90374&source=NDLTD&language=en.
Full textAbstract:
У раду је анализирана вaријабилност, генски ефекти, наслеђивање компонената приноса у укрштању пет сорти хексаплоидне пшенице (Triticum aestivum L.). Резултати истраживањаivуказују да између родитеља и генерација потомстaва постоје значајне разлике у средњим вредностима испитиваних својстава. Методом диалелног укрштања утврђена је комбинациона способност родитељских линија и добијене су информације о природи генских ефеката за важне агрономске особине. У наслеђивању компонената приноса (висина биљке, маса биљке, дужина класа, број зрна по класу, маса зрна по класу и маса зрна по биљци), применом адитивно-доминантног модела, уочено је присуство неалелне интеракције – епистазе. Aнализом међузависних односа установљене су значајне или високо значајне вредности коефицијената корелације између већине испитиваних својстава.U radu je analizirana varijabilnost, genski efekti, nasleđivanje komponenata prinosa u ukrštanju pet sorti heksaploidne pšenice (Triticum aestivum L.). Rezultati istraživanjaivukazuju da između roditelja i generacija potomstava postoje značajne razlike u srednjim vrednostima ispitivanih svojstava. Metodom dialelnog ukrštanja utvrđena je kombinaciona sposobnost roditeljskih linija i dobijene su informacije o prirodi genskih efekata za važne agronomske osobine. U nasleđivanju komponenata prinosa (visina biljke, masa biljke, dužina klasa, broj zrna po klasu, masa zrna po klasu i masa zrna po biljci), primenom aditivno-dominantnog modela, uočeno je prisustvo nealelne interakcije – epistaze. Analizom međuzavisnih odnosa ustanovljene su značajne ili visoko značajne vrednosti koeficijenata korelacije između većine ispitivanih svojstava.
A study has been conducted to assess variability, gene effect and inheritance of yield components in five crosses of hexaploid wheat genotypes (Triticum aestivum L.). The results of the study have shown that the mean values of parents and their progenies were significantly different. In diallelviicrossing information about combining ability of parental lines and the nature of genetic effects for some important agronomic traits had been obtained. Non-allelic interactions, epistatic gene effect, were observed in the inheritance of yield components (stem height, biomass, spike length, kernel number per spike, kernel weight per spike and kernel weight per plant) using the additive-dominance model. Significant and highly significant values of correlation coefficients were calculated for the most of studied traits.
17
Wu, Xiaoqi. "Zai', 'dao', and 'gei' constructions -- a study of Chinese word order /." The Ohio State University, 1996. http://rave.ohiolink.edu/etdc/view?acc_num=osu1487940665435198.
Full text
18
Borivoj, Sekulić. "Klinički i prognostički značaj ekspresije gena EVI1 u akutnoj mijeloidnoj leukemiji." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2015. https://www.cris.uns.ac.rs/record.jsf?recordId=95501&source=NDLTD&language=en.
Full textAbstract:
UVOD: Akutna mijeloidna leukemija (AML) predstavlja heterogenu grupu oboljenja u odnosu na morfologiju, citogenetiku, molekularnu genetiku, zbog čega se deli na različite kliničke i biološke entitete, sa različitim odgovorom na terapiju i ishodom lečenja. Humani EVI1 (ecotropic virus integration-1) gen ima ulogu multifunkcionalnog nuklearnog transkripcionog faktora, kako u normalnoj tako i u malignoj hematopoezi. Sve je više istraživanja koja ističu negativni prognostički značaj visoke ekspresije (overexpression) EVI1 gena u AML. CILJEVI: Ciljevi ovog istraživanja su da se ispita klinički i prognostički značaj ekspresije gena EVI1 u AML, kao i da se utvrdi povezanost visoke ekspresije gena EVI1 sa nalazima citogenetskog ispitivanja i molekularnim markerima: FLT3 mutacijom i nukleofozmin 1 (NPM1) mutacijom. MATERIJAL I METODE: Ovim prospektivnim istraživanjem je obuhvaćena grupa od 38 odraslih novodijagnostikovanih bolesnika sa de novo, non M3 AML, kod kojih je započeto standardno lečenje, a koji su dijagnostikovani i lečeni u Klinici za hematologiju Kliničkog centra Vojvodine u periodu od jula 2012. do marta 2014. Određivanje ekspresije gena EVI1 je vršeno pomoću real time kvantitativne PCR (qPCR) metode, tehnikom TaqMan, a relativna ekspresija EVI1 gena je određena primenom ΔΔCt metode. REZULTATI: Medijana starosti bolesnika pri postavljanju dijagnoze AML je bila 52 godine (23-80). Ustanovljena je statistički značajna razlika između ekspresije gena EVI1 kod zdravih osoba (kontrolna grupa) i obolelih od akutne mijeloidne leukemije (p=0.008). Računajući relativnu ekspresiju, 13,2 % bolesnika je imalo visoku ekspresiju (overexpression) gena EVI1. U odnosu na kliničke i laboratorijske karakteristike bolesnika (kao što su pol, starost, parametri krvne slike, nivo laktat dehidrogenaze, procenat blasta u perifernoj krvi i koštanoj srži, potom tip akutne mijeloidne leukemije, performans status, komorbiditetni indeks) nije ustanovljena statistički značajna razlika između bolesnika sa visokom ekspresijom EVI1 gena i ostalih bolesnika. Postoji statistički značajna povezanost visoke ekspresije EVI1 gena i nepostojanja NPM1 mutacije (p=0,031), kao i između visoke ekspresije EVI1 gena i prisustva monozomije 7 (p=0,047). Visoka ekspresija EVI1 gena je povezana sa kraćim preživaljvanjem bez dogaĎaja (p=0,004), kao i sa kraćim ukupnim preživljavanjem (p=0,025). ZAKLJUČCI: Postoji značajno povećana ekspresija gena EVI1 kod obolelih od AML u odnosu na zdrave kontrole. Visoka ekspresija EVI1 gena je faktor loše prognoze kod obolelih od akutne mijeloidne leukemije i u kombinaciji sa drugim prognostičkim markerima, doprinosi boljoj risk stratifikaciji ovih bolesnika.INTRODUCTION: Acute myeloid leukaemia (AML) represents a heterogenous group of diseases in terms of morphology, cytogenetics, molecular genetics, so it can be divided into distinct clinical and biological entities, with variable responsiveness to therapy and different treatment outcome. Human EVI1 (ecotropic virus integration-1) gene plays a role of multifunctional nuclear transcriptional factor, not only in normal, but also in malignant haematopoiesis. There are more and more investigations indicating high EVI1 expression (EVI1 overexpression) as a negative prognostic marker in AML. PURPOSES: The main goal of this investigation was to examine the clinical and prognostic significance of EVI1 expression in AML, as well as to investigate whether there was any association of EVI1 overexpression with cytogenetic abnormalities and other standard molecular prognostic factors, such as FLT3 mutation and nucleophosmin 1 (NPM1) mutation. PATIENTS AND METHODS: This prospective study included 38 adult newly diagnosed patients with de novo nonM3 AML, in whom a standard treatment was started at Clinic of Haematology, Clinical center of Vojvodina in the period from July 2012 to March 2014. EVI1 expression was analyzed by real-time quantitative polymerase chain reaction using TaqMan, and relative EVI1 expression was determined by ΔΔCt method. RESULTS: Median age of patients at diagnosis was 52 (aged 23-80). There has been determined statistically higher EVI1 expression in our AML patients than in healthy volunteers (control group) (p=0.008). The relative EVI1 overexpression was observed in 13.2% of the patients. No significant differences in clinical and laboratory patient data (including sex, age, whole blood counts, lactate dehydrogenase level, peripheral and bone marrow blast percentages, type of AML, performance status, comorbidity index) were observed between patients with high EVI1 expression and patients without high EVI1 expression. Our investigation revealed inverse correlation of high EVI1 expression and nucleophosmin 1 mutation (p=0,031). Also high EVI1 expression was significantly associated with monosomy 7 (p=0,047). Survival analysis revealed significantly inferior event free survival (p=0,004) and overall survival (p=0,025) for patients with high EVI1 expression compared to the other patients. CONCLUSION: EVI1 expression is significantly higher in AML patients compared to healthy controls. High EVI1 expression is a poor prognostic marker for patients with AML, and in combination with other well established prognostic markers, contributes to better risk stratification of these patients.
19
Mendes, Francisco Amancio Cardoso. "Física: uma língua(gem)." Universidade de São Paulo, 2010. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-05082010-105658/.
Full textAbstract:
Nosso trabalho foi desenvolvido no campo teórico e apresenta a tese de que a Física é uma língua(gem) juntamente com a hipótese de que seu ensino pode se pautar pelas teorias da Línguistica Aplicada voltadas ao ensino-aprendizagem de Segunda Língua (L2) e/ou de Língua Estrangeira (LE). Começando pelo ensino de Física, abordaremos os conceitos de Alfabetização e Letramento Científicos para mostrar que recentemente os pesquisadores têm se utilizado destes conceitos para se referir à Física como uma linguagem de maneira metafórica. Apresentamos algumas limitações sobre essa linha metafórica mostrando que a Física é uma língua(gem). Essa elucidação será feita com o auxílio da Linguística Práxis buscando uma possível definição de língua(gem), perpassando pelas linhas teóricas das Linguísticas Estrutural, Pragmática/Funcional e da Práxis/Enunciação. Em nosso alinhamento teórico dentro da Linguística Práxis apresentaremos a noção de símbolo, signo, instrumento de produção enunciativa e gêneros do discurso sempre ligados aos aspectos sociais, históricos e culturais da interação entre interlocutor e locutor para mostrar que a Física é uma língua(gem). Por fim, utilizaremos dos conceitos levantados pela Teoria da Atividade social, histórica e cultural para apresentar argumentos que corroborem com a hipótese levantada de que o ensino de Física pode ser trabalhado utilizando-se de teorias da Linguística Aplicada voltadas ao ensino-aprendizagem de L2 e/ou LE.Our research was developed in the theoretical field and presents the thesis that Physics is a language with the hypothesis that its teaching process can be guided by the theories of Applied Linguistics directed to the teaching and learning of a Second Language (L2) and/or a Foreign Language (FL). From the process of teaching and learning Physics, we discuss the concepts of Scientific Literacy to show that researchers have recently been using these concepts to refer to Physics as a language in a metaphorical way. We present some limitations in this metaphorical line showing that Physics is a language. This clarification will be made with the aid of Linguistic Praxis seeking a possible definition of language, making use of the theoretical lines of Structural Linguistics, Pragmatics / Functional Linguistics and Linguistic Praxis / Enunciation Theory. In our theoretical alignment with Linguistic Praxis we will present the notion of symbol, sign, tool for the production of enunciation and discourse genres always linked to the social, historical and cultural interaction between the speaker and the hearer to prove that Physics is a language. Finally, we will use the concepts raised by the Cultural and Historical Activity Theory to present arguments that corroborate the hypothesis that the teaching and learning of Physics can be dealt with using the theories of Applied Linguistics focused on the teaching and learning of L2 and / or FL.
20
Favaretto, Simone Aparecida Conceição. "Um discurso sobre a escolarização da língua materna: língua, linguagem e lingua(gem)." Universidade de São Paulo, 2013. http://www.teses.usp.br/teses/disponiveis/48/48134/tde-15052013-110336/.
Full textAbstract:
Este estudo teve o objetivo de problematizar a maneira como o ensino de língua materna pode funcionar como forma de modelar as subjetividades contemporâneas, nas interações vivenciadas pela criança-aluno que ocorrem na escola, da mesma forma que esse ensino evidencia a modelação das redes locais em relação ao sistema nacional. Em um diálogo cauteloso entre Michel Foucault, a Psicanálise e a Linguística, a teia discursiva que se estrutura a partir de tema tão complexo foi analisada, assim como sua forma de captura dos sujeitos no ambiente escolar e no próprio discurso educacional em vigor. Da análise do discurso foram utilizados elementos para compreender e fazer viver os saberes, postos no currículo de língua portuguesa de uma rede municipal do sistema educacional brasileiro, os quais, tratados como discurso de seus atores sociais sobre o manejo no ensino da língua materna, responderam às seguintes questões: Qual a relevância da comunicação, da linguagem, da língua e dos sujeitos no ensino de língua materna? Como se entende a formação do sujeito de linguagem? Quais são as práticas discursivas desejadas na articulação sujeitos-atores e língua, nas propostas de ensino da língua materna? Qual a importância das diferenças individuais nas políticas de ensino de língua materna? A delimitação dos referenciais teóricos que sustentam o ensino de língua materna como objeto de conhecimento e como estratégia de governamentalidade, no ambiente escolar, a perspectiva do currículo como documento de identidade e a apresentação da rede em discurso sobre o ensino pro-posto desencadearam o entrecruzamento das finalidades, objetivos, conteúdos e orientações didáticas, com os sentidos de língua, linguagem e infância materializados, permitindo pensar que a sujeição às diretrizes nacionais apagou o percurso histórico e a singularidade da rede local, ao mesmo tempo que o controle do discurso prescindiu da subjetividade como agente de expressão. Deste estudo decorreu a constatação de que a língua e a linguagem compõem o cenário de tensões entre os dispositivos de poder e o funcionamento dos sujeitos, assim como a forma pensada de ensinar escolariza a língua e aprisiona a ela e a seus agentes, o que faz pensar que a diferenciação entre língua e linguagem não é algo dispensável de reflexão nos dias de hoje.This study aimed to discuss how the teaching of native language can function as a way of modeling the contemporary subjectivities, the interactions experienced by the child-student in the school likewise that teaching emphasizes the modeling education networks of cities in compared to the national system. In a cautious dialogue between Michel Foucault, psychoanalysis and linguistics, the discursive structure from subject as complex was analyzed as well as their way of capturing the subject in the school environment and the own educational discourse in force. Of discourse analysis were used to understand the elements and the knowledge, put in the curriculum of portuguese language teaching in the a municipal educational system, which, treated as social actors talk about their management in native language teaching, answered the following questions: What is the relevance of communication, speech, language and subjects in native language teaching? What is the formation of the subject of language? What are the discursive practices desired joint subject-actors and language in the proposed teaching of native language? What is the importance of individual differences in the policies of native language teaching? The demarcation of the theoretical frameworks that underpin the teaching of native language as an object of knowledge and as a strategy of The demarcation of the theoretical frameworks that underpin the teaching of native language as an object of knowledge and as a strategy of governmentality, in the school environment, the prospect of the curriculum as an identity document and presentation of network discourse about teaching proposed triggered the intersection of purposes, goals, content and instructional guidance with the different meanings of language and childhood materialized, thinking that subjection to national guidelines erased the historical background and the uniqueness of the local school system, while control the discourse of subjectivity dispenses as agent expression. This study took the realization that the language set the scene of tensions between the power devices and operation of the subject, as well as the form designed to teach the language schooling and imprisons her and her agents, what makes you think that differentiation between the different meanings of the word language is not something dispensable for reflection today.
21
Arnaud, Vincent. "La dimension variationniste du français en usage à Saint-Claude (Haut-Jura) : une étude acoustique des voyelles orales des "gens d'en haut"." Besançon, 2005. http://www.theses.fr/2005BESA1035.
Full textAbstract:
Situé à proximité de la Suisse et sur une ancienne frontière linguistique, le Haut-Jura connaît une situation particulière. Outre les spécificités des patois aujourd'hui disparus, le français en usage à Saint-Claude présente un matériel lexical emprunté aux zones géographiques avoisinantes. Si les particularités historiques, économiques et géographiques confèrent à cette ville une valeur sociale de référence par rapport à l'environnement rural avoisinant, ce dynamisme ne peut faire oublier sa position isolée, en périphérie de l'Hexagone. Cette collectivité constitue donc un lieu d'enquête propice à l'examen d'une possible mutation de caractéristiques régionales en " dialectes de classes urbains " (LABOV, 1976). Reposant sur une analyse spectrographique des fréquences centrales des trois premiers formants, les voyelles orales sont extraites d'un corpus de dix-neuf témoins de sexe masculin, enregistrés lors d'entrevues sociolinguistique semi-dirigées. Les données formantiques récoltées témoignent du possible maintien de l'opposition entre /a/ antérieur et /A/ postérieur dans les usages de deux groupes d'âge disjoints : les plus 55 ans et les 20-35 ans. La comparaison des fréquences formantiques actualisées par ces deux groupes tend à indiquer une antériorisation des réalisations du /a/ antérieur et du /O/ ouvert en syllabe fermée chez les plus jeunes. Les analyses de régression linéaire suggèrent également que la distribution des données au sein des espaces biformantiques F1/F2 et F2/F3 est structurée en fonction du statut socioprofessionnel, du niveau d'études et du degré d'implication des locuteurs au sein de pratiques sociales reconnues comme spécifiquement localesThis study will focus on the acoustic analysis of oral vowels produced by native French speakers living in Saint–Claude, a small town located in the province of Haut–Jura. Located in the eastern part of France, more precisely north of Lake Geneva, it is characterised by a double boundary, i. E. An old linguistic boundary between the northern varieties of French (langues d'oïl) and Franco–provençal, and a geopolitical border between France and Switzerland. Saint-Claude being the only urban centre serving the surrounding villages, most services and industries are concentrated there. The vocalic tokens that were analysed are extracted from a corpus of spontaneous speech from nineteen male speakers, recorded during semi–directive interviews. The subjects are divided into two distinctive age groups: from 20 to 35 and over 55. The acoustic results indicate the possible upholding of the opposition between the /a/ et /A/ phonemes in these two age groups. Moreover, two different linear regression models confirm the impact of the variable age groups on F1, F2 and/or F3 distributions for the realisations of /a/ and /O/ phonemes produced in CVC context. If these two age groups are integrated as a common variable in these two models, they take into account two separate types of social variables. The first model is based on a supra-local social stratification (education level and socio-professional status). The second statistic model tends to calculate the effect of a locally-defined social stratification on the formants distribution. This sanclaudian stratification is based on a subjective scale developed to measure the degree of implication in the local community for each age group
22
Seng, Astrid. "10 Jahre FAMI-Ausbildung in Deutschland fachrichtungsübergreifende Studie zum beruflichen Verbleib der Absolventen." Berlin Humboldt-Univ., Inst. für Bibliotheks- und Informationswiss, 2009. http://edoc.hu-berlin.de/docviews/abstract.php?lang=ger&id=30078.
Full text
23
Plenker, Dennis [Verfasser], Thomas [Akademischer Betreuer] Langer, and Jürgen [Akademischer Betreuer] Wolf. "Functional analysis of CD74-NRG1 - a new recurrent oncogenic gene fusion in lung adenocarcinoma / Dennis Plenker. Gutachter: Thomas Langer ; Jürgen Wolf." Köln : Universitäts- und Stadtbibliothek Köln, 2015. http://d-nb.info/106681550X/34.
Full text
24
Abualhamayl, Abdullah Jameel Mr. "APPLY DATA CLUSTERING TO GENE EXPRESSION DATA." CSUSB ScholarWorks, 2015. https://scholarworks.lib.csusb.edu/etd/259.
Full textAbstract:
Data clustering plays an important role in effective analysis of gene expression. Although DNA microarray technology facilitates expression monitoring, several challenges arise when dealing with gene expression datasets. Some of these challenges are the enormous number of genes, the dimensionality of the data, and the change of data over time. The genetic groups which are biologically interlinked can be identified through clustering. This project aims to clarify the steps to apply clustering analysis of genes involved in a published dataset. The methodology for this project includes the selection of the dataset representation, the selection of gene datasets, Similarity Matrix Selection, the selection of clustering algorithm, and analysis tool. R language with the focus of Kmeans, fpc, hclust, and heatmap3 packages in R is used in this project as an analysis tool. Different clustering algorithms are used on Spellman dataset to illustrate how genes are grouped together in clusters which help to understand our genetic behaviors.
25
Munnick, James. "Romans et nouvellistes noirs en afrique du sud, de 1948 a 1986 : exploitation litteraire de la vie des gens de couleur." Toulouse 2, 1992. http://www.theses.fr/1992TOU20046.
Full textAbstract:
Analyse des oeuvres principales publiees en langue anglaise entre 1948 et 1986 par des ecrivains sud-africains de couleur (africains, metis et indiens). Ils seront dans cette etude globalement consideres comme "noirs". 1948 marque la date de l'instauration officielle de la politique dite d'"apartheid". L'evolution des noirs, vue au travers de leurs romans et nouvelles, qui les fait passer au cours de la meme generation de la defense passive a la resistance active. Sont abordes dans cette etude : le theme de l'alienation, la prise de conscience politique, les facteurs historiques, sociologiques, psychologiques, economiques et d'autres considerations politiques sont egalement pris en compte. L'etude se termine en 1986, l'annee du dixieme anniversaire des evenements de sowetoThis thesis is an analysis of writings in english between 1948 and 1986 by south african authors of colour (defined as africans, coloureds and indians). 1948 was the year of the official institution of the appartheid policy which aimed at permently separating whites and blacks. The study starts from an analysis of their short stories, novels and other writings which changes, reflecting the attitudes of blacks which were modified in the course of the same generation from passive defence to active resistance. The themes of alienation and the raising of political consciousness are considered, as are historical, sociological, psychological, economic and other political factors. The study terminates in 1986, the tenth anniversary of the soweto uprising
26
Branimir, Bajac. "Sinteza, mikrostruktura i funkcionalna karakterizacija multiferoičnih BaTiO3/NiFe2O4 višeslojnih tankih filmova." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2017. https://www.cris.uns.ac.rs/record.jsf?recordId=104952&source=NDLTD&language=en.
Full textAbstract:
Kroz istoriju, otkrivanje novih materijala i njihovog dizajna dovodilo je do tehnoloških revolucija. U prošlom veku, novi materijali naprednih svojstava uveli su elektronske uređaje u svakodnevni život čoveka. Industrija mikročipova predstavlja ogroman deo svetskog tržišta, i traži neprestan razvoj da bi pružila bolje proizvode potrošačima. Početkom ovog veka, nova grupa materijala, pod nazivom multiferoici, privukla je pažnju naučno-istraživačkog društva u svetu. Ovi materijali poseduju jedinstvenu karakteristiku da istovremeno ispoljavaju više od jedne feroične osobine (feroelektričnost, feromagnetizam, feroelastičnost), a što je još važnije, mogu da ostvare interakciju među njima. Naime, magnetizacija multiferoika se može postići primenom spoljašnjeg električnog polja, a takođe se mogu i polarisati primenom spoljašnjeg magnetnog polja. Ovo vrlo interesantno svojstvo otvara potencijlanu primenu u oblasti hibridne računarske memorije, senzora, aktuatora, i dr. Sredinom prošlog veka, jednofazni multiferoici su prvi privukli pažnju, ali poseldnjih godina, kompozitni multiferoici su pokazali bolje rezultate u pogledu funkcionalnih karakteristika. Trend minijaturizacije je takođe prisutan u ovoj oblasti, stoga su multiferoični tanki filmovi vrlo atraktivni u istraživačkih krugovima ne samo zbog niske potrošnje električne energije, malog utroška meterijala i malih dimenzija, već i zbog dobre magnetoelektrične interakcije. Glavni cilj ove doktorske disertacije je bio određivanje optimalnog procesa sinteze/depozicije, i vršenje strukturne i funkcionalne karakterizacije multiferoičnih višeslojnih tankih filmova, sačinjenih od naizmenično deponovanih feroelektričnih BaTiO3 i fero/ferimagnetnih NiFe2O4 slojeva (uglavnom na silicijumskim supstratima sa slojem platine). Različite strukture slojeva dizajnirane su u cilju određivanja optimalne, koja bi dala najviše vrednosti magnetoelektričnog efekta. U prvom koraku, sintetisani su stabilni solovi/rastvori prekursora, veličine čestica od nekoliko nanometara, reoloških karakteristika pogodnih za depoziciju tehnikama iz tečne faze. Višeslojni filmovi su dobijeni "spin" procesom nanošenja, pri čemu je termički tretman svakog sloja na 500 °C bio neophodan radi potpunog otparavanja zaostalog rastvarača. Filmovi bez pukotina, ukupne debljine ispod 1 μm, uniformne debljine sloja (60 nm sloj BaTiO3 i 40 nm sloj NiFe2O4) i ravne površine mogu biti dobijeni sinterovanjem u temperaturnom opsegu od 750 do 900 °C. Strukturna karakterizacija je potvrdila sistem bez prisustva sekundarnih faza, sačinjen od perovskitnog BaTiO3 i spinelnog NiFe2O4. Dielektrična merenja su bila u saglasnosti sa mikrostrukturnom analizom, i vrednostima dielektrične konstante tipične za nanostrukturni sistem, niske vrednosti dielektričnih gubitaka i male provodljivosti. Uticaj međuslojne polarizacije, koja nalikuje Debajeovoj relaksaciji, izražena kroz povećanje dielektrične konstante uspod 100 kHz, bio je jači u nižoj frekventnoj regiji na povišenim temperaturama usled termičke aktivacije nosilaca naelektrisanja u feritnoj fazi. Samo čist BaTiO3 film je pokazao slab feroelektrični histerezis nepotpune saturacije, malo više polarizacije filma sinterovanog na 900 °C usled ogrubljivanja strukture. Meuđuslojni efekti su takođe primećeni kod feroelektričnih merenja na sobnoj temperaturi, sa izraženijim prisustvom kada se primeni jače električno polje. Na osnovu dielektričnih i feroelektričnih merenja, zaključeno je da film sa debljim titanatnim i tanjim feritnim slojevima ima najverovatnije najbolji dizajn slojeva. Magnetne histerezisne petlje su snimljene na sobnoj temperaturi za čiste NiFe2O4 filmove i višeslojne filmove. Analizom višeslojnih filmova različitog dizajna slojeva, pretpostavljeno je da zatezanje nastalo mehaničkom interakcijom između titanatnih i feritnih slojeva jeste prisutno, i da raste sa povećanjem broja kontaktnih površina, stoga film sa tanjim titanatnim i feritnim slojevima verovatno predstavlja najbolji izbor sa aspekta megnetnih osobina.Through history, discovery of new materials and material design have led to technological revolutions. In the last century, new materials with advanced properties have introduced electronic devices in our everyday lives. Microchip industry represents one huge part of world market, and needs constant development to provide better products to consumers. In the beginning of this century, a novel group of materials, called multiferroics, have attracted close attention of research society around the world. These materials have a unique property to express more than one ferroic property simultaneously (feroelectricity, ferromagneticity, ferroelasticity), and more important, to achieve coupling between them. Namely, magnetization of multieferroic may be changed with application of external electric field, and they can be polarized with application of the external magnetic field. This is a very interesting property that opens the potential applications in fields of hybrid computer memory, sensors, actuators, etc. In the middle of last century, single phase multiferroics were the first to trigger interest in this special property, but in recent years, composite multiferroics have shown more promising results in terms of functional properties. The trend of miniaturization is also present in this field, so multiferroic thin films are very attractive for research not only because of low power and material consumption or small size, but also because of strong magnetoelectric coupling.The main goal of this thesis was to determine optimal synthesis/deposition process, and perform structural and functional characterization of multiferroic multilayer thin films, composed of ferroelectric BaTiO3 and ferro/ferrimagnetic NiFe2O4 layers in alternating order (mostly on platinum coated silicon substrates). Different layer structures were designed in order to find optimal one which could show the strongest magnetoelectric effect.In the first step, stable precursor sols/solutions were synthesized, with particle size of a few nanometes, and rheological properties suitable for solution deposition. The multilayered thin films were obtained by spin coating and thermal treatment of each layer on 500 °C was necessary in order to completely evaporate traces of residual solvents. Crack free films with overall thickness below 1 μm, uniform single layer thickness (60 nm of BaTiO3 layer and 40 nm of NiFe2O4) and flat surface can be obtained by sintering in temperature range from 750 to 900 °C. Structural characterization confirmed that secondary phase free system with microstructure on nanometer scale was obtained, composed of perovskite BaTiO3 and spinel NiFe2O4. Dielectric measurements were in agreement with microstructural characterization, showing the values of dielectric constant typical for nanostructured system, low values of dielectric losses and low conductivity. The influence of interfacial polarization, resembling Debye behavior, expressed as a rise of dielectric constant below 100 kHz, was stronger in lower frequency range on higher temperatures due to thermal activation of mobile charge carriers in ferrite phase. Only the pure BaTiO3 films showed weak unsaturated ferroelectric hysteresis loops, with slightly higher polarization of films sintered on 900 °C due to coarsening of the structure. The interface effects were also detected in ferroelectric measurements on room temperatures, showing increased presence when higher field is applied. Regarding dielectric and ferroelectric characterization, it was concluded that the multilayered films with thick titanate and thin ferrite layers may probably have the most promising layer design. Magnetic hysteresis loops were recorded on room temperatures for the pure NiFe2O4 and multilayers films. By analysis of different layer design of multilayers, it was assumed that mechanical straining between the ferrite and titanate layers may be present, and increases with the number of contact surfaces, thus the films with thinner titanate and ferrite layers may probably have the best layer design from aspect of magnetic properties.
27
Gevers, Nicholas David. "A study of the major science fiction works of Gene Wolfe." Master's thesis, University of Cape Town, 1991. http://hdl.handle.net/11427/21971.
Full textAbstract:
This thesis examines three major works by the American Science Fiction and Fantasy writer Gene Wolfe (Eugene Rodman Wolfe, 1931-). The central argument of this thesis is that in The Fifth Head of Cerberus (1972), the 'New Sun' cycle of novels (1980- 1987), and Soldier of the Mist (1986), Wolfe presents the human desire for knowledge of the Self and of God and the near-impossibility of attaining this knowledge. Wolfe expresses obstacles to knowledge and fulfilment in his created fictional worlds, in the characters of his protagonists, and in the complicated narrative structures that distinguish all three texts. By converting the stable and reassuring world of conventional Science Fiction into a realm of uncertainty, ambiguity, and spiritual and cognitive confusion, Wolfe radically subverts the genre and exposes it to a new subtlety and flexibility.
28
Ilija, Baroš. "Молекуларна и генска хетерогеност метастаза у аксиларним лимфним чворовима код пацијенткиња са инвазивним карциномом дојке." Phd thesis, Univerzitet u Novom Sadu, Medicinski fakultet u Novom Sadu, 2019. https://www.cris.uns.ac.rs/record.jsf?recordId=110238&source=NDLTD&language=en.
Full textAbstract:
HER2 Gene-Protein Assay (GPA) је посебно погодан за истовремено процењивање експресије HER2 протеина и статуса амплификације HER2 гена на нивоу појединачних ћелија и њихово повезивање са ћелијском морфологијом. Циљ истраживања био је испитати да ли су постојећи критеријуми препоручени од стране ASCO/CAP довољни за дијагностиковање HER2 позитивности код пацијенткиња које показују интратуморску хетерогеност, како у примарним туморима тако и у метастазама у регионалне лимфне чворове, учесталост HER2 хетерогености у макрометастазама лоцираним у лимфним чворовима, те да ли постоји јасна корелација између хетерогености нађене у примарном тумору дојке и припадајућим метастазама у лимфним чворовима. Испитивање је обухватило 41 од планиране 51 пацијенткиње које су испуниле све критеријуме укључивања. Репрезентативни парафински блокови метастатских лимфних чворова одабрани су из архивираног материјала, обојени GPA методом и процењени у складу са критеријумима ASCO/CAP 2013. Анализирано је 120 ћелија у хистолошком резу сваког метастатског лимфног чвора. Статус HER2 се разликовао између примарног тумора и његових метастаза у 13,2% (5/38) случајева. Један случај HER2 позитивног примарног тумора имао је HER2 негативне метастазе, два додатна случаја са HER2 позитивним примарним тумором су имала метастазе са статусом граничне амплификације без прекомерне експресије HER2 протеина и два случаја са HER2 негативним примарним тумором су имала метастазе са статусом граничне амплификације без прекомерне експресије HER2 протеина. У 17.4% (4/23) случајева са HER2 не-амплификованим примарним тумором метастазе су постале граничне у статусу генске амплификације. Једна од четири метастазе HER2 негативног примарног тумора показала је мали фокус HER2 позитивних туморских ћелија (<3% тумора). Микрохетерогеност је анализирана у 108 лимфних чворова код 38 пацијенткиња и уочена у 22 лимфна чвора, тј. код четири пацијенткиње у свим анализираним лимфним чворовима, док је код једне пацијенткиње од 4 анализирана лимфна чвора микрохетерогеност потврђена у једном лимфном чвору. На основу добијених резултата може се закључити да постојећи критеријуми препоручени од стране ASCO/CAP применом прихваћених метода нису довољни за дијагностиковање HER2 позитивности код пацијенткиња које показују интратуморску и интертуморску хетерогеност како у примарним туморима тако и у метастазама, те да постоји статистички високо сигнификантан број макрометастаза лоцираних у лимфним чворовима које показују HER2 хетерогеност и позитивна корелација између хетерогености нађене у примарним туморима и припадајућим метастазама у лимфним чворовима.HER2 Gene-Protein Assay (GPA) je posebno pogodan za istovremeno procenjivanje ekspresije HER2 proteina i statusa amplifikacije HER2 gena na nivou pojedinačnih ćelija i njihovo povezivanje sa ćelijskom morfologijom. Cilj istraživanja bio je ispitati da li su postojeći kriterijumi preporučeni od strane ASCO/CAP dovoljni za dijagnostikovanje HER2 pozitivnosti kod pacijentkinja koje pokazuju intratumorsku heterogenost, kako u primarnim tumorima tako i u metastazama u regionalne limfne čvorove, učestalost HER2 heterogenosti u makrometastazama lociranim u limfnim čvorovima, te da li postoji jasna korelacija između heterogenosti nađene u primarnom tumoru dojke i pripadajućim metastazama u limfnim čvorovima. Ispitivanje je obuhvatilo 41 od planirane 51 pacijentkinje koje su ispunile sve kriterijume uključivanja. Reprezentativni parafinski blokovi metastatskih limfnih čvorova odabrani su iz arhiviranog materijala, obojeni GPA metodom i procenjeni u skladu sa kriterijumima ASCO/CAP 2013. Analizirano je 120 ćelija u histološkom rezu svakog metastatskog limfnog čvora. Status HER2 se razlikovao između primarnog tumora i njegovih metastaza u 13,2% (5/38) slučajeva. Jedan slučaj HER2 pozitivnog primarnog tumora imao je HER2 negativne metastaze, dva dodatna slučaja sa HER2 pozitivnim primarnim tumorom su imala metastaze sa statusom granične amplifikacije bez prekomerne ekspresije HER2 proteina i dva slučaja sa HER2 negativnim primarnim tumorom su imala metastaze sa statusom granične amplifikacije bez prekomerne ekspresije HER2 proteina. U 17.4% (4/23) slučajeva sa HER2 ne-amplifikovanim primarnim tumorom metastaze su postale granične u statusu genske amplifikacije. Jedna od četiri metastaze HER2 negativnog primarnog tumora pokazala je mali fokus HER2 pozitivnih tumorskih ćelija (<3% tumora). Mikroheterogenost je analizirana u 108 limfnih čvorova kod 38 pacijentkinja i uočena u 22 limfna čvora, tj. kod četiri pacijentkinje u svim analiziranim limfnim čvorovima, dok je kod jedne pacijentkinje od 4 analizirana limfna čvora mikroheterogenost potvrđena u jednom limfnom čvoru. Na osnovu dobijenih rezultata može se zaključiti da postojeći kriterijumi preporučeni od strane ASCO/CAP primenom prihvaćenih metoda nisu dovoljni za dijagnostikovanje HER2 pozitivnosti kod pacijentkinja koje pokazuju intratumorsku i intertumorsku heterogenost kako u primarnim tumorima tako i u metastazama, te da postoji statistički visoko signifikantan broj makrometastaza lociranih u limfnim čvorovima koje pokazuju HER2 heterogenost i pozitivna korelacija između heterogenosti nađene u primarnim tumorima i pripadajućim metastazama u limfnim čvorovima.
HER2 Gene Protein Assay (GPA) is particularly convenient to simultaneously assess the expression of HER2 protein and the amplification status of the HER2 gene at individual cell level and to correlate them with cellular morphology. The aim of the study was to examine whether the existing criteria recommended by ASCO / CAP are sufficient for diagnosing HER2 positivity in patients showing intratumoral heterogeneity, both in primary tumors and in metastases in regional lymph nodes, the frequency of HER2 heterogeneity in macrometastases located in the lymph nodes, and whether there is a clear correlation between the heterogeneity found in the primary tumor of the breast and the associated metastases in the lymph nodes. The study included 41 of the planned 51 female patients which fulfilling all the inclusion criteria. Representative paraffin blocks of metastatic lymph nodes were selected from archived material, stained with the GPA and assessed in accordance with the ASCO/CAP 2013 criteria. We analyzed 120 cells per section of each metastatic lymph node. The HER2 status differed between the primary tumor and its metastases in 13.2% (5/38) of the cases. A single case of HER2 positive primary tumor had HER2 negative metastases, two additional cases with HER2 positive primary tumor had metastases with equivocal amplification status without protein overexpression and two cases with HER2 negative primary tumors had metastases with equivocal amplification status without protein overexpression. The HER2 status of the lymph node metastases within the same patient having at least two metastatic nodes showed only subtle variations. In 17.4% (4/23) of the cases with HER2 non-amplified primary tumor the metastases became equivocal in gene-amplification status. One out of the four metastases of a HER2 negative primary tumor showed a small focus of HER2 positive tumor cells (<3% of the tumor). Microheterogeneity was analyzed in 108 lymph nodes in 38 patients and observed in 22 lymph nodes, i.e. in four patients in all analyzed lymph nodes, while in one patient of 4 lymph node analyzed, microheterogeneity was confirmed in one lymph node. Based on the obtained results, it can be concluded that the existing criteria recommended by ASCO / CAP using the accepted methods are not sufficient to diagnose HER2 positivity in patients showing intratumoral and intertumoral heterogeneity both in primary tumors and in metastases, and that there is statistically significant number of macrometases located in the lymph nodes showing HER2 heterogeneity and a positive correlation between the heterogeneity found in primary tumors and associated metastases in the lymph nodes.
29
Ivan, Stijepović. "Dobijanje lantan-galata za primenu u gorivnim ćelijama." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2012. https://www.cris.uns.ac.rs/record.jsf?recordId=85671&source=NDLTD&language=en.
Full textAbstract:
U ovom radu su sintetisani prahovi na bazi lantan-galata, citratnom sol-gelmetodom i hemijskom sintezom u parnoj fazi (CVS), a njihovim presovanjemi sinterovanjem su dobijeni keramički uzorci kontrolisane mikrostrukture. Ciljdisertacije je bio dobijanje guste keramike koja bi mogla da se primeni kaojonski provodni elektrolit u gorivnim ćelijama sa čvrstim elektrolitom (SOFC),a koje bi radile na srednjim temperaturama od 500–700 °C (IT-SOFC). Po prviput su sintetisani nanoprahovi lantan-galata u gasnoj fazi i utvrđeno je da ovakodobijeni polazni prahovi, zbog svojih superiornih karakteristika omogućavajusnižavanje temperature sinterovanja za 150 °C, što je veoma povoljno kako sastanovišta dizajniranja mikrostrukture, tako i zbog uštede energije u procesuproizvodnje gorivnih ćelija. Ipak, zbog nedovoljne kontrole hemijskog sastavai stehiometrije sintetisanih prahova, što je i najveći nedostatak CVS metodedobijanja perovskitnog LaGaO3, nije bilo moguće dobiti keramiku koja bi ispunjavala zahteve za primenu u SOFC. S druge strane, citratna sol-gel metodapruža veliku kontrolu pomenutih parametara zbog čega je bila moguća sintezačitavog niza čvrstih rastvora lantan-galata. Ovom metodom su tako sintetisaničist lantan-galat (LG) i dopirani prahovi kod kojih je deo lantana supstituisanstroncijumom, a deo galijuma magnezijumom: La0,85Sr0,15Ga0,85Mg0,15O3-La1-xSrxGa0,8Mg0,2O3-, gde je x = 0,10, 0,15 ili 0,20 (LSGM). Svi ovako sintetisaniprahovi su zahtevali naknadnu kalcinaciju na 900 °C, ali su potrebnegustine (>95% teorijske gustine) postignute sinterovanjem na temperaturiod 1450 °C već nakon 2 h, što je izuzetno kratko imajući u vidu literaturnepodatke. Takođe, sinterovani uzorci su po faznom sastavu bili čista LSGMkeramika, a impedansna merenja su pokazala da je najveću provodljivost imaouzorak La0,85Sr0,15Ga0,8Mg0,2O3-. Ovaj sastav je dalje korišćen u cilju proveremogućnosti za dodatno povećanje provodljivosti te su pripremljeni i uzorci kod kojih je izvršena parcijalna supstitucija magnezijuma sa niklom ili kobaltom:La0,85Sr0,15Ga0,8Mg0,2-yMyO3-, gde je M = Ni ili Co, a y = 0,03 ili 0,05 (LSGMN iLSGMC). Pokazano je da dodatak male količine prelaznih metala značajno utičena mehanizam provođenja, ali da je na višim temperaturama jonska provodljivosti dalje dominantna. Konstatovano je da se dodavanjem male količine Ni ili Co uLSGM mogu dobiti materijali koji bi služili kao elektroliti u IT-SOFC, pri čemu jepotencijal nikla kao dopanta nešto veći nego kobalta.Powders based on lanthanum-gallate have been synthesised in this work by using citrate sol-gel method in the liquid phase and by chemical vapour synthesis (CVS). As-synthesised powders were calcined, pressed and finally sintered in order to produce ceramic samples with controlled microstructure. The main goal of this dissertation has been obtaining of dense ceramics for application in ion conducting electrolyte for solid oxide fuel cells working at 500–700 °C (IT-SOFC). Lanthanum-gallate nanopowders have been synthesised in the gas phase for the first time and it has been determined that these starting powders posses superior properties which could lower down the sintering temperature for about 150 °C. This is very significant considering microstructure design, but also high energy consumption during the manufacturing process of fuel cells. However, it has not been possible to obtain ceramics with exact properties needed for SOFC application using CVS due to the lack of control of chemical composition and stoichiometry of the as-synthesised powders, which are the main drawbacks of this method. On the other hand, citrate sol-gel method offered a possibility to precisely control aforementioned parameters which enabled synthesis of a whole range of lanthanum-gallate sollid solutions. So, pure perovskite lanthanum-gallate (LG) has been synthesised by using this liquid phase method, but also doped powders where part of lanthanum and gallium was supstituted with strontium and magnesium, respectively: La0,85Sr0,15Ga0,85Mg0,15O3- and La1-xSrxGa0,8Mg0,2O3-, where x = 0.10, 0.15 or 0.20 (LSGM). Calcination at 900 °C was necessary step during the processing of these sol-gel powders but the sintering time at 1450 °C was only 2 h which is quite short in comparison with available literature data. Additionaly, the sintered samples were phase pure LSGM ceramics and impedance measurement showed that the highest conductivity had sample La0,85Sr0,15Ga0,8Mg0,2O3-. Accordingly, this composition has been used to check the possibility of further improvement of conductivity. A set of new samples has been prepared where one part of magnesium has been substituted with nickel or cobalt: La0,85Sr0,15Ga0,8Mg0,2-yMyO3-, where M = Ni or Co and y = 0.03 or 0.05 (LSGMN i LSGMC). It has been shown that addition of small amount of transition metals significantly influences conduction mechanism, but at higher temperatures the ionic conductivity is still dominant. It has been found that electrolyte materials for IT-SOFCs could be obtained by incorporation of small quantities of Ni or Co into LSGM and that nickel is more promissing for this purpose than cobalt.
30
Bojana, Lanté. "Sinteza nanoprahova i dobijanje kompozitne keramike sa magnetnom i dielektričnom fazom za primenu u mikroelektronici." Phd thesis, Univerzitet u Novom Sadu, Tehnološki fakultet Novi Sad, 2014. https://www.cris.uns.ac.rs/record.jsf?recordId=89906&source=NDLTD&language=en.
Full textAbstract:
U ovom radu sintetisani su kompozitni nanoprahovi i nanoprahovi tipa jezgro– omotač sa dielektričnom i magnetnom fazom, kao pogodan polazni materijal za procesiranje kompozitne keramike za primenu u mikroelektronici. Osnovni cilj ove doktorske disertacije je bio utvrđivanje veza između uslova sinteze, morfologije čestica, uslova procesiranja i mikrostrukture kompozitne keramike. Nanoprahovi su sintetisani hemijskim metodama sinteze u tečnoj fazi (sol-gel i koprecipitacija) i gasnoj fazi (CVS), pri čemu je vršena optimizacija procesnih uslova u cilju sinteze čestica željene strukture i hemijskog sastava. Istraživanja su vršena na nekoliko modelnih sistema sa feritima kao magnetnom fazom i titanatima ili silikom kao dielektričnom fazom: NiFe2O4SiO2, Fe3O4SiO2, SrTiO3NiFe2O4, BaTiO3NiFe2O4 i BaTiO3Fe3O4. Hemijska sinteza u tečnoj fazi se pokazala pogodnom zato što pruža mogućnost kontrolisanja morfologije kompozitnih čestica ne samo podešavanjem procesnih parametara sinteze već i funkcionalizacijom faza kojom se uzrokuje njihovo elektrostatičko privlačenje i formiranje strukture jezgro–omotač. Ipak, zbog velikog stepena aglomeracije prisutnog tokom sinteze u tečnoj fazi, dobijanje omotača uniformne debljine i izbegavanje homogene nukleacije faza se pokazalo teško. Hemijskom sintezom u gasnoj fazi (CVS) je po prvi put sintetisan kompozitni nanoprah na bazi kompleksnih oksida titanata i ferita.Utvrđeno je da i pored velikog potencijala CVS metode u smislu sinteze ultrafinih prahova na bazi titanata i ferita u jednom koraku, ova metoda nudi relativno slabu kontrolu morfologije kompozitnih čestica pri visokim procesnim temperaturama koje su neophodne za kristalizaciju dve faze. Sintetisani nanoprahovi na bazi titanata i ferita (SrTiO3NiFe2O4 i BaTiO3NiFe2O4) procesirani su u gustu kompozitnu keramiku visokotemperaturnim sinterovanjem, u cilju ispitivanja veze morfologije čestica i mikrostrukture kompozita, optimizacije režima sinterovanja i funkcionalne karakterizacije dobijene keramike sa različitim masenim odnosom faza. Prahovi su sinterovani putem konvencionalnog sinterovanja u atmosferi vazduha, spark plazma sinterovanja (SPS) ili kombinacijom ove dve metode. Utvrđeno je da prahovi strukture jezgro–omotač densifikuju u značajno gušću i homogeniju keramiku u odnosu na kompozitne prahove istog sastava na istim procesnim temperaturama. Pored toga, pH vrednost sinteze čestica i atmosfera visokotemperaturnog sinterovanja su se pokazali veoma značajnim u smislu održavanja željenog faznog sastava dobijenih kompozita. U pogledu režima sinterovanja dobijenih prahova, kombinacija niskotemperaturnog konvencionalnog i SPS sinterovanja (1000 °C) je dala najbolje rezultate u smislu postizanja zadovoljavajuće gustine kompozita (>95% teorijske gustine), održavanja željenog faznog sastava i homogene distribucije faza. Funkcionalna karakterizacija sinterovane keramike sa različitim masenim odnosom faza (BaTiO3 : NiFe2O4 = 1,2,8) potvrdila je očekivano dielektrično, feroelektrično i ferimagnetno ponašanje dobijenih kompozita.Composite and core–shell nanopowders with dielectric and magnetic phase have been synthesized in this work, as a suitable starting material for processing of composite ceramics for microelectronic application. The main goal of this doctoral dissertation was the determination of the link between synthesis conditions, particle morphology, processing conditions and microstructure of composite ceramics. Nanopowders have been synthesized by chemical synthesis methods in wet phase (sol–gel and coprecipitation) and gas phase (CVS), whereas the optimization of processing parameters was conducted with the goal to synthesize particles of desired structure and chemical composition. Studies were conducted on the few model systems with ferrites as a magnetic and titanates as a dielectric phase: NiFe2O4SiO2, Fe3O4SiO2, SrTiO3NiFe2O4, BaTiO3NiFe2O4 and BaTiO3Fe3O4. Chemical wet synthesis has proven suitable because it offers composite particle morphology control not only by adjustment of synthesis parameters but also by phase functionalization causing their mutual electrostatic attraction and thus core–shell structure formation. However, due to the high degree of agglomeration present during the wet phase synthesis, formation of the shell with uniform thickness and avoidance of homogeneous nucleation has proven difficult. For the first time, composite ferrite and titanate-based nanopowder has been synthesized by means of Chemical Vapor Synthesis (CVS). It has been found that beside high potential of CVS method for one-step synthesis of ultrafine titanate and ferrite-based nanopowders, this method offers relatively low control of composite particle morphology at high processing temperatures which are necessary for crystallization of both phases. Synthesized titanate and ferrite-based nanopowders (SrTiO3NiFe2O4 and BaTiO3NiFe2O4) were processed into dense ceramics by high-temperature sintering, in order to find the link between particle morphology and composite microstructure, optimize the sintering regime and conduct the functional characterization of obtained ceramics with different phase mass ratio.The powders were sintered by conventional sintering in air, spark plasma sintering(SPS) or combination of these two methods. It was found that core–shell powders densify in ceramics with considerably higher density and homogeneity at the same processing temperature, than the composite powders with the same composition. Moreover, synthesis pH value and sintering temperature was found to be very important in terms of phase composition preservation of obtained composites. Regarding the sintering regime of obtained powders, combination of low-temperature conventional and SPS sintering (1000 °C) has given the best results in terms of achieving adequate composite density (>95% theoretical density), phase preservation and homogeneous phase distribution. Functional characterization of sintered ceramics with different phase mass ratio (BaTiO3 : NiFe2O4 = 1,2,8) confirmed the expected dielectric, ferroelectric and ferromagnetic behaviour of obtained composites.
31
Yang, Jianji. "Automatic summarization of mouse gene information for microarray analysis by functional gene clustering and ranking of sentences in MEDLINE abstracts : a dissertation." Oregon Health & Science University, 2007. http://content.ohsu.edu/u?/etd,643.
Full textAbstract:
Ph.D.Medical Informatics and Clinical Epidemiology
Tools to automatically summarize gene information from the literature have the potential to help genomics researchers better interpret gene expression data and investigate biological pathways. Even though several useful human-curated databases of information about genes already exist, these have significant limitations. First, their construction requires intensive human labor. Second, curation of genes lags behind the rapid publication rate of new research and discoveries. Finally, most of the curated knowledge is limited to information on single genes. As such, most original and up-to-date knowledge on genes can only be found in the immense amount of unstructured, free text biomedical literature. Genomic researchers frequently encounter the task of finding information on sets of differentially expressed genes from the results of common highthroughput technologies like microarray experiments. However, finding information on a set of genes by manually searching and scanning the literature is a time-consuming and daunting task for scientists. For example, PubMed, the first choice of literature research for biologists, usually returns hundreds of references for a search on a single gene in reverse chronological order. Therefore, a tool to summarize the available textual information on genes could be a valuable tool for scientists. In this study, we adapted automatic summarization technologies to the biomedical domain to build a query-based, task-specific automatic summarizer of information on mouse genes studied in microarray experiments - mouse Gene Information Clustering and Summarization System (GICSS). GICSS first clusters a set of differentially expressed genes by Medical Subject Heading (MeSH), Gene Ontology (GO), and free text features into functionally similar groups;next it presents summaries for each gene as ranked sentences extracted from MEDLINE abstracts, with the ranking emphasizing the relation between genes, similarity to the function cluster it belongs to, and recency. GICSS is available as a web application with links to the PubMed (www.pubmed.gov) website for each extracted sentence. It integrates two related steps, functional gene clustering and gene information gathering, of the microarray data analysis process. The information from the clustering step was used to construct the context for summarization. The evaluation of the system was conducted with scientists who were analyzing their real microarray datasets. The evaluation results showed that GICSS can provide meaningful clusters for real users in the genomic research area. In addition, the results also indicated that presenting sentences in the abstract can provide more important information to the user than just showing the title in the default PubMed format. Both domain-specific and non-domain-specific terminologies contributed in the informative sentences selection. Summarization may serve as a useful tool to help scientists to access information at the time of microarray data analysis. Further research includes setting up the automatic update of MEDLINE records; extending and fine-tuning of the feature parameters for sentence scoring using the available evaluation data; and expanding GICSS to incorporate textual information from other species. Finally, dissemination and integration of GICSS into the current workflow of the microarray analysis process will help to make GICSS a truly useful tool for the targeted users, biomedical genomics researchers.
32
Ribeiro, Maíry Aparecida Pereira Soares. "A DESGRAMATICALIZAÇÃO DO ENSINO DA LINGUA(GEM)." Pontifícia Universidade Católica de Goiás, 2004. http://localhost:8080/tede/handle/tede/1122.
Full textAbstract:
Made available in DSpace on 2016-07-27T13:53:17Z (GMT). No. of bitstreams: 1
MAIRY APARECIDA PEREIRA SOARES RIBEIRO.pdf: 392688 bytes, checksum: 5fc8fff4fb58897a059a03c0e8a16c7f (MD5)
Previous issue date: 2004-10-07This research which objet is the Desgramatização of the language suggests a teaching that possibility to the student to perceive the language in its essence, one time that it is intrinsic to the student. For this, the boundary of the theme, because discuss the traditional grammar s teach, such as in the classic age; if today in the modern world the science is a pure product of the modern spirit, and don t have roots neither in the human prefiguração. So, for its development with proficiency was utilised the biographical research, having as theorical reference the study of Greeks like Platao, Apolonio and Dionisio about grammar and other studious like Foucault, Deleuze, Arnauld and Lancelot, Detienne, Elias, Bachelard and other important studious. For this, in the first part has a description and origin of the grammar in the Hellenistic Word. In the beginning with one form of analyse of the language (origin), then as a nomenclature grammatical that going to grow rich and establishing the traditional grammar with phonology, morphology and syntax, which is the bequest Greek that subsists the study of language in the classic age, especially the grammarians of Port- Royal, with a Grammatical Geral ou Razoada. The second part is about the desgramaticalização of the language s teach, whose intension is to teach the language starting with the profile of the students and not of the Normative Grammar. In the third part, considerations of how to give the practice about the teach of the language and its rules that regulate, understand that it follow still the Greek slope, that is, the traditional grammar. For end, the last considerations are initial reflections of how the language s teach and the form desgramaticalizando can be discovery from the secret faces existent in the language.
Esta pesquisa cujo objeto é a Desgramaticalização do ensino da Língua(gem) propõe um ensino que possibilite ao aluno perceber a linguagem em sua essência, uma vez que ela está intrínseca a ele, por isso a delimitação do tema, pois questiona-se por que ainda se ensina a gramática tradicional, tal qual na idade clássica; se hoje no mundo moderno a ciência é puro produto do espírito moderno, e não tem raízes nem na prefiguração humana. Dessa forma, para o seu desenvolvimento com proficiência foi utilizada a pesquisa bibliográfica, tendo como referencial teórico os estudos dos gregos Platão, Apolônio e Dionísio sobre a gramática, além de obras de estudiosos como Foucault, Deleuze, Arnauld e Lancelot, Detienne, Elias, Bachelard dentre outros. Por conseguinte, na primeira parte tem-se a descrição das origens da gramática no mundo helenístico, no início como uma forma de analisar os princípios da linguagem, em seguida como uma nomenclatura gramatical que vai se enriquecendo e constituindo a gramática tradicional composta de fonologia, morfologia e sintaxe, a qual é o legado grego que subsidia os estudos da linguagem na idade clássica, sobretudo dos gramáticos de Port-Royal, com a Gramática Geral ou Razoada. Na Segunda parte, a desgramaticalização do ensino da língua(gem) cuja proposta é ensinar a língua a partir dos perfis dos alunos e não da gramática normativa. Na terceira parte, apontamentos de como se dá a prática do ensino da língua e as leis que o regulam, percebendo-se que ele ainda segue a vertente grega, ou seja a Gramática Tradicional. Por fim, as considerações finais que são reflexões iniciais de como o ensino da língua de forma desgramaticalizado pode ser a descoberta das faces secretas contidas na língua(gem).
33
Mak, Ah-yee Lena. "Cantonese-speaking children's use of the aspect markers 'jo' and 'gan' in three experimental tasks /." [Hong Kong : University of Hong Kong], 1993. http://sunzi.lib.hku.hk/hkuto/record.jsp?B13686628.
Full text
34
Schuhmann, Britta [Verfasser]. "Vergleichende Untersuchungen zur Zusammensetzung, Dichte und mechanischen Belastbarkeit sowie zum histologischen Aufbau der langen Röhrenknochen von Greifvögeln und Eulen / Britta Schuhmann, geb. Horn." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1026359228/34.
Full text
35
Marina, Putnik-Delić. "Fiziološki i molekularni aspekti tolerantnosti šećerne repe prema suši." Phd thesis, Univerzitet u Novom Sadu, Poljoprivredni fakultet u Novom Sadu, 2013. https://www.cris.uns.ac.rs/record.jsf?recordId=95411&source=NDLTD&language=en.
Full textAbstract:
Istraživanja su sprovedena na jedanaest genotipova šećerne repe (Beta vulgaris ssp. vulgaris, L., označeni brojevima 1-11) koji su u poljskim uslovima ispoljili razlike u opservacionom testu nivoa tolerantnosti prema suši (visoko, srednje i nisko tolerantni). U prvom delu eksperimenta biljke su gajene u polukontrolisanim uslovima, u stakleniku u supstratu koji je bio mešavina zemlje i peska. Biljke su svakodnevno zalivane tokom 90 dana, nakon čega je izazvan vodni deficit prestankom zalivanja, dok je kod kontrolnih biljaka zalivanje nastavljeno. Pet dana po prestanku zalivanja analizirani su parametri koji bi trebalo da ukažu na genotipske razlike u smislu tolerantnosti prema nedostatku vode. Utvrđen je sadržaj vode/suve materije u zemljištu i u biljnim tkivima (koren stablo i list). Lisna površina i koncentracija pigmenata hloroplasta su ustanovljeni kod kontrolnih biljaka s ciljem utvrđivanja genotipskih specifičnosti. Osim toga, mereni su parametri fluorescencije hlorofila (F0, Fm, Fv, Fv/Fm i t1/2) kako bi se utvrdio efekat stresa izazvanog nedostatkom vode na inhibiciju transporta elektrona kroz PSII, i koncentracija slobodnog prolina, amino kiseline koja se nakuplja u uslovima stresa. U drugom delu eksperimenta ovi genotipovi su testirani u kontrolisanim, in vitro uslovima gajenja. Aksilarni izdanci su gajeni na podlozi za mikropropagaciju sa 0 (kontrola), 3 i 5% polietilen glikola (PEG 6000) pune četiri nedelje, a potom su vršene analize. Utvrđena je sveža masa izdanaka, sadržaj suve materije i koncentracija slobodnog prolina. U trećem delu eksperimenta upoređene su razlike u ekspresiji 13 kandidat-gena, koji su povezani sa reakcijom biljaka na uslove stresa, posebno suše, u listovima biljaka gajenih u polukontrolisanim uslovima.
Biljke izložene stresu u polukontrolisanim uslovima gajenja su u proseku imale oko tri lista manje, za četiri procenta veći udeo suve materije i sedmostruko veći sadržaj prolina. Koncentracija prolina u listovima je bila viša u uslovima nedostatka vode u polukontrolisanim uslovima kod svih genotipova, a posebno kod nekih iz slabo tolerantne (2, 6) i visoko tolerantne (4) grupe.
U in vitro uslovima usled tretmanom PEG-om smanjila se ukupna suva masa i više nego prepolovio broj aksilarnih izdanaka. PEG u koncentraciji od 3% je doveo do
povećanja ukupne sveže mase, a koncentracija prolina se povećala se porastom koncentracije PEG. Koncentracija prolina u uslovima stresa je kod oba eksperimenta bila značajno povećana u odnosu na kontrolu i to u in vitro uslovima šest puta, a u polukontrolisanim uslovima u stakleniku šesnaest puta u odnosu na odgovarajuće kontrole. Povećanje sadržaja prolina u biljkama gajenim u polukontrolisanim uslovima je bilo tri puta veće u odnosu na eksperiment sa PEG-om.
Koncentracija slobodnog prolina, kao jedan od potencijalnih parametara - pokazatelja tolerantnosti genotipova šećerne repe prema suši, je adekvatniji od ukupne suve mase. Rezultati su pokazali da je test u in vitro uslovima (posebno tretman 3% PEG-om) efikasiji za ocenu tolerantnosti prema suši od eksperimenta u polukontrolisanim uslovima. Grupisanje genotipova prema nivou tolerisanja nedostatka vode na osnovu koncentracije prolina ustanovljene u ekperimentu in vitro dalo je isti rezultat kao i opservacioni test u poljskim uslovima.
Utvrđene su promene u ekspresiji kandidat-gena u uslovima suše u odnosu na kontrolu, a ustanovljene su i razlike između genotipova. Jedan od analiziranih kandidat-gena može da posluži za dalji razvoj markera.
Ovi rezultati mogu da se primene u procesu oplemenjivanja šećerne repe koje je usmereno na povećanje tolerantnosti prema ovom abiotičkom činiocu.
36
Patrukhina, Liubov. "À la recherche des particules modales dans les cours pour débutants ˸ étude expérimentale dans le cadre de l’enseignement-apprentissage de l’allemand langue étrangère en France et en Russie." Thesis, Paris 3, 2019. http://www.theses.fr/2019PA030037.
Full textAbstract:
Cette recherche a pour objet l’étude de l’enseignement-apprentissage des particules modales allemandes par un public non-germanophone de niveau débutant. Ce travail cherche en premier lieu à définir si l’introduction explicite et précoce de ces particules en classe d’allemand langue étrangère favorise leur production et leur compréhension. Deuxièmement, il tente de déterminer si la langue de scolarisation des apprenants influence le processus d’appropriation des particules modales allemandes. Le premier chapitre pose le cadre conceptuel du travail, en retraçant les principales notions mobilisées en linguistique et en didactique des langues : la linguistique contrastive, la linguistique de corpus, la théorie des actes de langage, les méthodes de l’enseignement-apprentissage des langues étrangères. Il présente également le corpus de l’allemand parlé recueilli à des fins didactiques auprès de jeunes germanophones. Le deuxième chapitre analyse les méthodes de présentation des particules modales dans les manuels et les grammaires de l’allemand langue étrangère ainsi que dans les dictionnaires et cahiers d’exercices consacrés à ce sujet. À la suite de cette analyse, nous proposons notre propre approche, basée sur deux supports innovants : des enregistrements didactisés de notre corpus et des tableaux bilingues qui expliquent en allemand, en français ou en russe le fonctionnement des particules modales. Le troisième chapitre expose la mise en œuvre de cette méthode lors d’une expérience didactique menée auprès d’apprenants franco-, russo- et sinophones. La thèse débouche sur des propositions méthodologiques pour l’enseignement-apprentissage des particules modales allemandesThe research presented in this dissertation analyzes the acquisition of German modal particles by beginner-level learners. This project seeks firstly to ascertain if introducing the particles early and explicitly into the German-as-a-foreign-language can help learners to understand and use them more effectively. Secondly, it attempts to determine whether learners’ mother tongue influences the acquisition process of German modal particles. The first chapter sets the conceptual background, retracing the concepts in linguistics and language didactics that are fundamental to this study: Contrastive Linguistics, Corpus Linguistics, and Speech Acts Theory, as well as Foreign Language Teaching Methods and Approaches. It also presents the corpus of young peoples’ spoken German collected specifically for the didactic purposes of this dissertation. The second chapter analyzes the different methods of teaching modal particles put forward in textbooks and grammar books, as well as in dictionaries and exercise books devoted to the subject. Following this review, I propose my own approach based on two innovative teaching tools: recordings from my corpus of spoken German, and bilingual tables with comments in German, French or Russian on how German modal particles function. The third chapter describes the implementation of my method by presenting the results from an experiment of teaching German-as-a-foreign-language to French-, Russian- and Chinese-speaking learners. The thesis ends with methodological recommendations for teaching German modal particles
Die vorliegende Dissertation hat zum Ziel, den Erwerb der Modalpartikeln durch DaF-Lernende auf Anfängerniveau zu untersuchen. Allem voran wird der Frage nachgegangen, ob und wenn ja wie, eine explizite und frühe Behandlung der Modalpartikeln im DaF-Unterricht deren Produktion und Verständnis fördern kann. Anschließend wird der Versuch unternommen, einen möglichen positiven Einfluss der Muttersprache auf den Erwerb deutscher Modalpartikeln herauszufinden. Das erste Kapitel setzt den theoretischen Rahmen der Dissertation, indem es linguistische und sprachdidaktische Konzepte darlegt, die grundlegend für diese Arbeit sind: kontrastive Linguistik, Korpuslinguistik, Sprechakttheorie und Methoden des Fremdsprachenunterrichts. Es wird außerdem das Korpus “Gesprochenes Deutsch junger Muttersprachler“ beschrieben, das gezielt für die didaktischen Zwecke der Dissertation zusammengestellt worden ist. Im zweiten Kapitel werden Ansätze und Methoden zur Einführung der Modalpartikeln durchleuchtet, die in modernen DaF-Lehrwerken und Grammatiken sowie in thematischen Lexika und Übungsbüchern eingesetzt werden. Im Anschluss wird die eigene Herangehensweise dargestellt, die auf zwei innovativen Lehrmaterialien fußt: Didaktisierte Audioaufnahmen aus dem Korpus und zweisprachige Tabellen, die auf Deutsch, Französisch oder Russisch den Gebrauch der Modalpartikeln erläutern. Im dritten Kapitel wird die Umsetzung dieses Ansatzes beschrieben, der im Rahmen eines experimentellen DaF-Unterrichts mit russisch-, französisch- und chinesischsprachigen Deutschlernenden auf die Probe gestellt wurde. Abschließend werden methodische Vorschläge zur Behandlung der Modalpartikeln im DaF-Unterricht gemacht
37
Chan, Yick Mei Keriner. "The functions and occurrence patterns of aspect markers jo, gwo, gan, jyuh in Cantonese narrative discourse." HKBU Institutional Repository, 1999. http://repository.hkbu.edu.hk/etd_ra/401.
Full text
38
Musa, Khalid Bin. "Identifying Land Use Changes and It's Socio-Economic Impacts : A Case Study of Chacoria Sundarban in Bangladesh." Thesis, Linköping : Linköping University. Department of Computer and Information Science, 2008. http://www.diva-portal.org/smash/get/diva2:2076/FULLTEXT03.
Full text
39
Wiesner, Tobias [Verfasser], Wolfgang A. [Akademischer Betreuer] Wall, Ulrich [Akademischer Betreuer] Langer, and Michael W. [Akademischer Betreuer] Gee. "Flexible Aggregation-based Algebraic Multigrid Methods for Contact and Flow Problems / Tobias Wiesner. Gutachter: Wolfgang A. Wall ; Ulrich Langer ; Michael W. Gee. Betreuer: Wolfgang A. Wall." München : Universitätsbibliothek der TU München, 2015. http://d-nb.info/1067233326/34.
Full text
40
洪宣, 朴., and Hongsun Park. "Analysis of non-coding RNA expression in medium spiny neurons of Huntington disease model mice." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13106336/?lang=0, 2019. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB13106336/?lang=0.
Full textAbstract:
Huntington Disease (HD) is a neurodegenerative disorder caused by expanded CAG repeats in the exon1 of huntingtin gene (HTT). The mutant HTT affects the transcriptional profile of neurons by disrupting the activities of transcriptional machinery and alters expression of many genes. In this study, we identified dysregulated non-coding RNAs (ncRNAs) in medium spiny neurons of 4-week-old HD model mouse. Also, we observed the intracellular localizations of Abhd11os and Neat1 ncRNAs by ViewRNA in situ hybridization, which could provide more precise detection, suggesting that it is a useful method to investigate the expression changes of genes with low expression levels.博士(理学)
Doctor of Philosophy in Science
同志社大学
Doshisha University
41
信彦, 山邊. "PA-MBE法によるSi基板を用いたダブルバッファー層上 AIN,GaN成長." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12238275/?lang=0, 2011. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12238275/?lang=0.
Full text
42
Carneiro, Alan Silvio Ribeiro 1981. "Políticas linguísticas e identidades sociais em trânsito : língua(gem) e construção da diferença em Timor-Leste." [s.n.], 2014. http://repositorio.unicamp.br/jspui/handle/REPOSIP/269686.
Full textAbstract:
Orientador: Terezinha de Jesus Machado MaherTese (doutorado) - Universidade Estadual de Campinas, Instituto de Estudos da Linguagem
Made available in DSpace on 2018-08-25T20:15:32Z (GMT). No. of bitstreams: 1 Carneiro_AlanSilvioRibeiro_D.pdf: 1994806 bytes, checksum: 4cd57977a8f2f9e220c6dcf070a4baf3 (MD5) Previous issue date: 2014
Resumo: A investigação aqui descrita tem sua origem na minha atuação como professor de português como segunda língua no contexto multilíngue de Timor-Leste, entre 2008 e 2009. Esse pequeno país do Sudeste Asiático foi uma colônia portuguesa até 1975, sofreu uma violenta ocupação da Indonésia até 1999, passou por um período de transição sob a administração de uma missão da ONU (Organização das Nações Unidas) e se tornou independente em 2002. A Constituição timorense define como línguas oficiais do país, o português e o tétum e define o indonésio e o inglês como línguas de trabalho, designando ainda as línguas dos diferentes grupos etnolinguísticos locais como línguas nacionais. O país tem contado com a cooperação de diversos países na construção das suas políticas públicas, o que inclui a implementação das políticas linguísticas e educacionais. A cooperação brasileira e a cooperação portuguesa têm tido um papel importante na formação de professores através de diversas iniciativas construídas em conjunto com as diferentes instituições de governo em Timor-Leste. Dentro desse contexto, esta tese tem como foco professores formados atuando em Díli e estudantes em formação de um desses projetos, o curso de Licenciatura em Língua Portuguesa, do Departamento de Língua Portuguesa (DLP) da Universidade Nacional Timor Lorosa¿e (UNTL). O referido curso conta com a cooperação do Camões - Instituto da Cooperação e da Língua (CICL), de Portugal, através do Centro de Língua Portuguesa (CLP), de Díli. O objetivo principal desta pesquisa foi identificar as visões desses professores e estudantes em relação às suas trajetórias sociais, aos seus repertórios heteroglóssicos e às políticas linguísticas locais. A produção dos dados para a pesquisa empreendida foi realizada ao longo de seis meses em campo, no ano de 2012, momento em que atuei novamente como professor no país e pude registrar no meu diário de campo alguns aspectos da dinâmica sociolinguística local e produzir as oito entrevistas com professores formados e as oito entrevistas com estudantes em formação, com enfoque nas suas histórias de vida. As análises das narrativas apontaram para a forma como certos recursos linguísticos foram construídos nas suas trajetórias como recursos para mobilidade territorial e social; as suas perspectivas acerca do funcionamento atual dos repertórios heteroglóssicos locais que indiciam o funcionamento de hierarquias linguísticas e a sua vinculação a processos de distinção social; e ainda, a forma como para esses professores e estudantes, os debates sobre as políticas linguísticas que estão sendo implementadas no país se relacionam a processos de construção de hegemonia política no contexto timorense. Os resultados parciais me levam a defender a tese de que em um contexto multilíngue como o de Timor-Leste, as políticas linguísticas, como parte de regimes metadiscursivos de regulação das práticas sociais de interação, são também um dos eixos a partir do qual são estruturados os processos de construção identitária e de estratificação social constitutivos da atual ordem política do território e da nação, por isso, devendo ser analisadas no âmbito das disputas políticas por hegemonia nesse contexto
Abstract: The origin of this research was my professional activity as a teacher of Portuguese as second language in the multilingual setting of Timor-Leste, between 2008 and 2009. This small country of Southeast Asia was a former colony of Portugal until 1975 and then was violently occupied by Indonesia until 1999. The country remained under the administration of a UN mission until 2002, when it became independent. The Timorese Constitution defines as official languages, Portuguese and Tetun and defines Indonesian and English as working languages, naming also the diverse local languages as national languages. The country has been receiving the support of different cooperation agencies in the building of its policies, including the implementation of the language-in-education policies. The Brazilian and the Portuguese cooperation have an important role in the training of teachers through different initiatives built with different Timorese government institutions. In this context, this thesis has as a focus students and graduated Portuguese language teachers working in Díli from one of these projects, the undergraduate course in Portuguese language of Portuguese Language Department (DLP) of the National University Timor Lorosa'e, which count on the support of Camões-Instituto da Cooperação e da Língua (CICL), from Portugal, through the local based Portuguese Language Center (CLP). The main objective of this research was to identify the perspectives of these teachers and students in relation to their social trajectories, their heteroglossic repertoires and the local language policies. The gathering of data for this research was done during six months of fieldwork, in 2012, when I went back to Timor-Leste working as a volunteer teacher in the university. At the same time, I made a register in my field diary of different aspects of the local sociolinguistic dynamics and I produced the eight interviews with graduated teachers and the eight interviews with students, with a focus on their life histories. The analysis of their narratives indicated to the way linguistic resources were built in their trajectories as resources for social and territorial mobility; the ways their perspectives about the local heteroglossic repertoires points out to linguistic hierarchies and their connection with social distinction; as well as the manner the debates around the policies being implemented in the country are related to the construction of political hegemony in Timor-Leste. These partial results lead me to defend the thesis that in a multilingual context like the one of Timor-Leste, the language policies, as part of metadiscursive regimes of regulation of social practices are also one of the axis, which structures the processes of identity construction and of social stratification that constitutes the contemporary political order of the territory and of the nation, and because of this should be analysed as part of the political disputes for hegemony in this context
Doutorado
Multiculturalismo, Plurilinguismo e Educação Bilingue
Doutor em Linguística Aplicada
43
Koutses, Alexandra [Verfasser], Stefan [Gutachter] Langer, and Frank-Werner [Gutachter] Peter. "Klinische Studie zur Versorgung einer standardisierten Wunde (Spalthautentnahme) mit einem wundabdeckenden Gel im Vergleich zu Silbersulfadiazin-Creme / Alexandra Koutses ; Gutachter: Stefan Langer, Frank-Werner Peter ; Medizinische Fakultät." Bochum : Ruhr-Universität Bochum, 2010. http://d-nb.info/1230628533/34.
Full text
44
Heywood, Jacqualine, and n/a. "'Talking' and 'doing' gene technology politics: a policy analysis." Griffith University. Australian School of Environmental Studies, 2004. http://www4.gu.edu.au:8080/adt-root/public/adt-QGU20041029.100010.
Full textAbstract:
This thesis explores the environmental politics surrounding agricultural biotechnology innovations and diffusion. Recent developments in agricultural biotechnology are accompanied by growing social concerns that such innovations pose risks to the environment and to human health. Biosafety is a term used to discuss the possibility of such risks. Currently, the regulation of agricultural gene-technology and biosafety are contentious environmental issues for national and international policy communities. However, detailed studies of the conflicts and complexities generated by biotechnology for environmental governance are scarce. In particular, little is understood of the ways in which biotechnology issues emerge on regulatory agendas, and research gaps remain on how differing perspectives of biotechnological risks impact on policy outcomes. This thesis makes a significant contribution to these outstanding research issues. My contribution is a new analytical framework that unearths the discursive role biotechnology plays in constructing international environmental policy regimes. I develop this framework on the understanding that the use of language resources like storylines, metaphors and other rhetorical devices are critical in shaping environmental policy in general and biotechnology governance in particular. This analytical framework couples a language analysis to an investigation of the practices of institutional power. The result is a discourse analysis that provides important and useful insights into the theory and practice of biosafety policy. In other words, my thesis explores both the talking and the doing of policymaking and thereby provides new insights into the contested and uncertain environmental policy area of international gene-technology regulation. Specifically, I undertake a discourse analysis of international biosafety politics within the Convention on Biological Diversity. I apply my discourse analysis to a case study: the Cartagena Protocol on Biosafety to the Convention on Biological Diversity, 2000. My research provides a different reading of international gene-technology politics, one that questions the constructed nature of biotechnology as a policy problem and reveals the power relations involved in producing particular policy options and outcomes on biosafety. There are a number of key research findings that emerged from the application of my discursive analytical framework to the Cartagena Protocol on Biosafety. I find that biosafety is a highly fluid concept. It can enlarge or contract depending on the way in which language resources are mobilised by policy actors and interest groups to secure definitions and generate consensus around their preferred understandings of biosafety. Moreover, my research indicates that the more radical texts for biosafety can be recast by dominant interest groups into scripts for shallow reform agendas. Institutionalised policy practices also effect policy outcomes. My research finds that the use of Expert Panels, for example, is important in shaping international policy communities understanding of the policy problems posed by biotechnology risks. In the light of these findings, my thesis argues that the ability of interest groups and policy actors to win language games within institutional settings also enables them to secure their preferred policy outcomes. I import the concept of authorship as a new policy concept to discuss the ways in which such groups exercise social power to secure their understanding of biosafety, which thereby effect the writing of the dominant accounts of what constitutes an acceptable international biosafety standard within the Cartagena Protocol. In short, my thesis is a new account of biosafety politics that fills some of the current knowledge gaps about how biotechnology is emerging onto regulatory agendas. It also demonstrates the mechanisms of power and the language struggles that determine biosafety policy outcomes within multi-lateral environmental agreements such as the Convention on Biological Diversity.
45
Vos, Maria. "Kry (“get”)-passives in Afrikaans : a minimalist analysis." Stellenbosch : Stellenbosch University, 2013. http://hdl.handle.net/10019.1/85879.
Full textAbstract:
Thesis (MA)--Stellenbosch University, 2013.ENGLISH ABSTRACT: This study focuses on the grammatical properties and syntactic derivation of KRY (“get”)-passives in Afrikaans. Analyses of the corresponding phenomenon in other West-Germanic languages are examined and used as background for the study. The aim of the study is to provide a minimalist analysis of the internal structure of Afrikaans KRY-passives; no such analysis has to date been attempted within the framework of Minimalist Syntax. As an introduction to the phenomenon in Afrikaans, some grammatical background about kry and its syntactic distribution is provided, with special attention paid to the use of this verb in passive constructions. A new analysis of Afrikaans KRY-passives is put forward involving a small clause structure and a light verb component. The main hypothesis of the analysis is that eventive and stative KRY-passives are derived in basically the same manner, the important difference being the presence of a [process] and a [stative] feature, respectively, on the small clause light verb. This hypothesis provides support for the idea that the eventual eventive or stative interpretation of the structure is a consequence of the derivational process rather than being based on lexical features that are already present at the start of the derivation.
AFRIKAANSE OPSOMMING: Hierdie studie fokus op die grammatikale eienskappe en sintaktiese afleiding van KRY-passiewe in Afrikaans. Analises van die ooreenstemmende verskynsel in ander Wes-Germaanse tale word ondersoek en as vertrekpunt vir die studie gebruik. Die doel van die studie is om ‟n minimalistiese analise van die interne struktuur van Afrikaanse KRY-passiewe te ontwikkel; so ‟n analise is nog nie tevore binne die raamwerk van Minimalistiese Sintaksis aangebied nie. As algemene inleiding tot die verskynsel in Afrikaans, word enkele aspekte van kry se grammatikale eienskappe en sintaktiese verspreiding beskryf, met besondere klem op die gebruik van hierdie werkwoord in passiefkonstruksies. ‟n Nuwe analise van KRY-passiewe in Afrikaans word voorgestel, een wat gebruik maak van ‟n beknopte sin (“small clause”)-struktuur en ‟n ligte werkwoord (“light verb”)-komponent. Die vernaamste hipotese van die analise is dat gebeurtenis (“eventive”) en toestand (oftewel statief, “stative”) KRY-passiewe wesenlik op dieselfde manier afgelei word, met een belangrike verskil, naamlik die teenwoordigheid van, onderskeidelik, ‟n [proses]- en ‟n [statief]-kenmerk by die beknopte sin se ligte werkwoord. Dié hipotese verleen steun aan die idee dat die uiteindelike gebeurtenis- of toestand-interpretasie van die struktuur die gevolg is van die afleidingsproses, en dus nie gebaseer is op leksikale kenmerke wat reeds teenwoordig is by die aanvang van die afleiding nie.
46
Pedersen, Michael. "Modular languages for systems and synthetic biology." Thesis, University of Edinburgh, 2010. http://hdl.handle.net/1842/4602.
Full textAbstract:
Systems biology is a rapidly growing field which seeks a refined quantitative understanding of organisms, particularly studying how molecular species such as metabolites, proteins and genes interact in cells to form the complex emerging behaviour exhibited by living systems. Synthetic biology is a related and emerging field which seeks to engineer new organisms for practical purposes. Both fields can benefit from formal languages for modelling, simulation and analysis. In systems biology there is however a trade-off in the landscape of existing formal languages: some are modular but may be difficult for some biologists to understand (e.g. process calculi) while others are more intuitive but monolithic (e.g. rule-based languages). The first major contribution of this thesis is to bridge this gap with a Language for Biochemical Systems (LBS). LBS is based on the modular Calculus of Biochemical Systems and adds e.g. parameterised modules with subtyping and a notion of nondeterminism for handling combinatorial explosion. LBS can also incorporate other rule-based languages such as Kappa, hence adding modularity to these. Modularity is important for a rational structuring of models but can also be exploited in analysis as is shown for the specific case of Petri net flows. On the synthetic biology side, none of the few existing dedicated languages allow for a high-level description of designs that can be automatically translated into DNA sequences for implementation in living cells. The second major contribution of this thesis is exactly such a language for Genetic Engineering of Cells (GEC). GEC exploits the recent advent of standard genetic parts (“biobricks”) and allows for the composition of such parts into genes in a modular and abstract manner using logical constraints. GEC programs can then be translated to DNA sequences using a constraint satisfaction engine based on a given database of genetic parts.
47
Hadjem, Ammar Saïd. "Traitement d'image du gel d'électrophorèse bidimensionnelle." Nancy 1, 1988. http://www.theses.fr/1988NAN10143.
Full textAbstract:
L'objectif de ce travail est le traitement d'images du gel d'électrophorès bidimensionnelle (détection des taches de protéines, détermination automatique du nombre de taches de protéines sur le gel, la surface de chaque tache, leur position ainsi que leur densité optique ou en d'autres termes leur intensité lumineuse respective) en utilisant l'interface de numérisation associé à une caméra vidéo et à un micro-calculateur. Le travail a consisté, d'une part à mettre en œuvre une façon pratique cette nouvelle méthode d'investigation et d'autre part, à créer le logiciel assurant un fonctionnement jugé optimal pour ce type de fonctions (traitements d'images vidéo). L'autre partie de mon sujet est le travail expérimental en mettant au point les supports logiciels et techniques de la manipulation. En préliminaire est exposée une méthode originale de stockage des données numériques relatives à la partie comprise dans la fenêtre de mémorisation à position programmable ; la procédure de transfert de ces données dans le micro-calculateur en vue de leur traitement informatique est également présentée
48
Caner, Berkman Ceren. "Comparative Analyses For The Central Asian Contribution To Anatolian Gene Pool With Reference To Balkans." Phd thesis, METU, 2006. http://etd.lib.metu.edu.tr/upload/12607764/index.pdf.
Full textAbstract:
Around 1000 ya, Turkic language started to be introduced to Turkey and Azerbaijan
(Region of language replacement, RLR) in parallel with the migrations of Turkic
speaking nomadic groups from Central Asia. The Central Asian contribution to the
RLR was analyzed with four admixture methods considering different evolutionary
forces. Furthermore, the association between the Central Asian contribution and the
language replacement episode was estimated by comparatively analyzing the Central
Asian contribution to RLR and to their non-Turkic speaking neighbors.
In the present study, analyses revealed that Chikhi et al.&rsquos (2001) method represents the closest estimates to the true Central Asian contributions. Based on this method, it was observed that there were lower male (13%) than female (22%) contributions from Central Asia to Anatolia, with wide ranges of confidence intervals. Lower contribution, with respect to males, is to be explained by homogenization between the males of the Balkans and those of Anatolia. In Azerbaijan this contribution was 18% in females and 32% in males. Moreover, results pointed out that the Central Asian contribution in RLR can not be totally attributed to the language replacement episode because similar, or even higher, Central Asian contributions in northern and southern non-Turkic speaking neighbors were observed. The presence of a 20% or more admixture proportion in the RLR, and the presence of even higher contributions around the region, suggested that language might not be replaced inaccordance with &ldquo
elite dominance model&rdquo
.
49
久詞, 加藤, and Hisashi Kato. "Mechanisms of circadian regulation of exercise training-enhanced lipolysis in rat adipocytes." Thesis, https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12998784/?lang=0, 2016. https://doors.doshisha.ac.jp/opac/opac_link/bibid/BB12998784/?lang=0.
Full text
50
Lee, Che-hung. "Guangzhou fang yan yong yu "du" gan rao xue sheng shu mian yu xue xi qing kuang chu tan A study on the influence of the Cantonese word "Dou" in the learning of written Chinese of Hong Kong students /." Click to view the E-thesis via HKUTO, 2008. http://sunzi.lib.hku.hk/hkuto/record/B42554275.
Full text