Journal articles on the topic 'George' s Cross'

In 2011, I came across a Jerusalem type of icon in the chapel of the “St.  Demetrius” church in Arbanasy.  Due to the long-term exposure to humidity and dust, it needed an urgent restoration and conservation. However, in the museum data it was signed that the place of origin of the icon was the church of St. George in Arbanasy. After a research over older photographic documents, I’ve found that the icon was hang on the wall of the nave of this church, and eventually, due to the church’s closure for restoration, it was moved in the chapel of St. Demetrius church in the same village. After an urgent repair it was strengthened, cleaned and restored in the Regional museum of History – VelikoTarnovo. In spite of the urgent measures, the icon’s contents were inaccessible and not researched, which aroused my scientific interest. Up in the right corner, on the back, the Jerusalem icon is signed in Greek language, as follows: ΧΑ[ΔΖΙ]: NIKOΛAΥ TΟΥ ΔΗΜΗΤΡΙΥ ΑΠΟ ΤΗΝ ΜΕΓΑ ΤΡΝΟΒΑ ΑΡΒΑΝΤΟΧΌΡΙ. 1849. The painted side of the icon comprises inscriptions in Greek language with parallel additions of Bulgarian-language inscriptions. Each scene is presented not in chronological, but in compositional order. Four scenes in the upper register are from the Old Testament: Creation of Adam and Eve, The Fall, The Expel from the Paradise, Cain murders Abel. In the upper half of the front side is presented a multi-figural composition of the Last Judgment. In the middle, on a throne is seated Jesus, clad in archbishop vestments (as a Superior Bishop and a Judge, at the same time), flanked by the pleading Holy Virgin and St. John the Baptist, and the twelve apostles. In the scene’s both corners, traditionally are presented the two symbolical saints warriors – St. George and St. Demetrius, both on horsebacks. In the complicated iconographic scheme, traditionally as it could be seen in other examples is depicted a second register dedicated to the Holy Virgin. Her affectionate image is surrounded by 18 medallions with plots that are literally visualizing texts from the hymnography. In the centre of the icon is presented a large-scale map of the interior of the Jerusalem church “The Nativity of Christ” surrounded by golden walls. The composition itself is divided into three arcaded segments, which are depicting existing parts of The Hill of Golgotha, the Holy grave itself allocated under the altar of the church itself (Áãéïò ÔÜ5ïò) and the Resurrection of Jesus Christ. The rest of the composition, in the arcaded area is depicted Jesus Christ Almighty, holding a sphere with a golden cross – a symbol of the whole world taken by the Christianity. In the broad frame around His image are ordered 18 significant episodes: 1. Christ teaches in the Temple; 2. Healing of the Leper; 3. The Meeting with the Samaritan woman at the Well, 4. Healing of the Blind; 5.The Meeting with Zacchaeus up a tree; 6. The Ascension of Christ; 7. The Resurrection of Lazarus; 8. “Entry into Jerusalem; 9. The Last Supper; 10. The prayer in the Gethsemane garden; 11. Washing of the Feet of the Disciples; 12. The Betrayal of JudasIskariot; 13. Christ at the trial of Pilot of Pontius; 14. Peter’s Denial; 15. Apostle Peter’s repentance; 16. The Whipping of Christ; 17. Mocking of Christ; 18. Hanging on the Cross. After examining the icon and comparing it to other examples from monasteries and churches on the territory of Bulgaria, I can conclude that this type of iconography is popular and repetitive for the second half of the XIX century. In some of the examples we can read the names of Bulgarian icon-painters (or at least such that are working in Bulgarian language), carefully implemented and reflecting the icon-veneration in the years of the Ottoman domination. In regard to the style of the Jerusalem icon from Arbanasy – despite the naпve details – there is a tendency to precision and attention to the detail, a knowledge on the church hymnography, an affinity to the contrast colours and use of gold, without catchlights or complicated highlighting on the garments. In the context of the common stylistic forms of this type of church art during the mature period of the Bulgarian Revival, the researched icon is not an exception. In terms of artistry impressive is the complicated panoramic topography, the elegant result from the shrunk figures, the bilingual inscriptions, as well as the fact that the main theme is not omitted – the temple of The Nativity of Christ and the festive liturgy in it.

As a textual study, this research paper aims at elaborating the rhetorical patterns in the American mind by examining the inaugural addresses George W Bush particularly on the spirit of mission. The study on this topic becomes urgent to be discussed in relation to the importance of understanding a rhetoric pattern in terms of developing teaching material for cross cultural awareness and language skills. The choosing of the presidents inaugural address as the mental evidences is not apart from the synthesis that they represents a formal speech which covers the socio-cultural aspects and they will bring a certain pattern of rhetoric in their attempt to communicate with public. For the purpose of achieving the aim of this research, the library research is carried out by applying Goffman?s Frame Analysis. The results show that the president constructs a certain pattern of rhetoric by using the Puritan expressions particularly for engaging American people with the spirit of mission. The rhetoric patterns are found to convey the national and world mission. The expressions used in the inaugural addresses seem to meet with peoples expectations as a new presidency is begun

This article looks at the intersection between men’s fashion, ambiguous masculine identities and the emerging media form of music video in the AIDS-darkened early 1980s. It asks two questions: firstly, what enabled sartorial features in masculine fashion and grooming previously associated with queer-identifying men to cross over into the mainstream fashion culture of the 1980s? Secondly, how was it that in the startlingly homophobic climate of this ‘age of AIDS’, sexually ambiguous figures such as Wham!’s George Michael became such popular style role models? The article addresses these questions by arguing that Elvis Presley’s Jailhouse Rock (1957) – a strong stylistic influence on Wake Me Up Before You Go-Go by Wham! in 1984 – is an example of the Camp trace that remains when Camp aesthetics are removed from explicitly queer contexts. It argues that Jailhouse Rock is a dramatization of situational homosexuality, a mid-twentieth-century understanding of same-sex attraction between straight-identifying men, a precedent that permits the homoerotic group dynamic of Wham!. The article then explains how fashion worn by Michael in Wake Me Up Before You Go-Go – namely British designer Katherine Hamnett’s CHOOSE LIFE slogan T-shirt, and an alternative costume in which the colour pink is most prominent – demonstrates an intersection between fashion and politics for gay men in the 1980s. It also discusses Michael as an example of the New Man, an advertising and media trope of the 1980s that represented a blurring between queer masculine style and a new straight stereotype.

BACKGROUND: Previous studies have shown a reduction in health-related quality of life (HRQoL) in patients with non-tuberculous mycobacterial pulmonary disease (NTM-PD). However, the causes of this decline and the factors that contribute to it are unknown. This study was conducted to analyse the association between the St George´s Respiratory Questionnaire (SGRQ) and clinical parameters, including age, disease duration, body composition, pulmonary function, chest X-ray findings, blood data and physical function.METHODS: We performed a single-centre, cross-sectional, retrospective study of 101 patients with NTM-PD from December 2016 to October 2019. The relationship between the SGRQ scores and clinical parameters was evaluated.RESULTS: The median patient age was 67.0 years. Pulmonary function, radiological score, albumin levels, C-reactive protein levels and incremental shuttle walk test distance (ISWD) were significantly correlated with the total and component scores on the SGRQ. Multiple regression analysis showed that the SGRQ score was significantly associated with radiological score, pulmonary function and ISWD.CONCLUSION: This study was the first to assess the effect of clinical parameters on the SGRQ in patients with NTM-PD. HRQoL as determined using the SGRQ was associated with the radiological score, pulmonary function and ISWD in patients with NTM-PD.

Joseph T. Angelo quit a well-paid job at the DuPont Powder Works in Carney’s Point, New Jersey, to join the army. On September 26, 1918, he saved the life of then Lt. Colonel (temporary) George S. Patton Jr., an act that earned him the Distinguished Service Cross and provided him with a lifetime of minor renown. By 1931, during the Great Depression, Angelo was unemployed. He walked 160 miles to Washington, DC, from his hometown of Camden, New Jersey, to testify in front of Congress in support of immediate payment of the wartime bonuses promised to veterans of World War I. The following summer, he was among the Bonus Marchers who were brutally driven out of their encampments in the nation’s capital by the same U.S. military in which they had served during wartime. 
 This article tells Angelo’s story, and by doing so, it tells the story of the tens of thousands of desperate veterans of the Great War who united to form an ethnically and racially diverse movement to protest for what they believed was right and just. They had made sacrifices to defend American values on the battlefield and now sought to be treated in a manner they saw as fair.

Spawning sources of King George whiting Sillaginodes punctatus populations in the states of South Australia and Victoria (south-eastern Australia) were analysed using otolith chemistry and microstructure from post-larvae sampled from 3 nursery areas in each state in the spring of 2011 and 2012. Univariate and multivariate analysis of the chemistry of the core region of otoliths showed differences between states, particularly for the 2011 cohort, primarily related to higher Mg in South Australian samples, while differences in Sr and Zn also made a contribution. Even though spawning times overlapped, early larval growth rates were higher for post-larvae from South Australia than Victoria. Differences in microchemistry were most evident for elements influenced by physiological processes and were potentially influenced by the different larval growth rates. Overall, otolith chemical and microstructure analyses for post-larvae in Victoria and South Australia indicated that spawning sources for the 2 states were different, qualified by results from otolith microchemistry that were less clear for the 2012 cohort. Even though genetic analyses do not indicate genetic differentiation across the 2 states, and therefore would support cross-jurisdictional management, the results of this study give qualified support to the current arrangement wherein the S. punctatus fishery is managed separately by the individual jurisdictions, subject to further information on stock structure coming to light in the future.

<strong>ABSTRACT</strong> The world health organization has been recommending increased efforts to generate data on individuals with different occupational exposures. The Human exposure to environmental and occupational chemicals has increased considerably in past 55 years. Pesticised are among the most produced and used chemicals all over the globe. Pesticides constitute a heterogeneous category of chemicals specifically designed for the control of pests, weeds or plant diseases. Exposure to pesticides at any point in the life cycle has the potential for causing a range of short term health problems. The risk and severity of adverse health effects from pesticide exposure varies&nbsp; significantly depending on many factors including individual characteristics such as age and health status, duration of exposure etc,. The women workers working in the agricultural fields form a high risk group as the main crops are Paddy, Cotton and Chillies are grown in ParkalMandal, Warangal District.&nbsp; The present study consists of 100 pesticide women workers and 100 controls with no exposure of pesticides. The epidemiological data was collected from the exposed and control groups using a standard questionnaire. The results showed an increased incidence of health problems and impaired reproductive performance in women occupationally exposed to pesticides when compared to controls, which might be due to the prolonged exposure of workers to pesticides in the cotton fields. <strong>Keywords</strong>: Pesticides, Health problems, Reproductive performance. <strong>REFERENCES</strong> Food and Agriculture Organization of the United Nations FAO international code of conduct on the distribution and use of pesticides Rome. 1986. Schettler T, Solomon G, Kaplan J, Valenti M. Generations at Risk: How Environmental Toxicants May Affect Reproductive Health in California. Brisbane, CA: George Lithograph; 2003. Henderson PT, Borm PJA, Kant dri IJ. BasisboekArbeidstoxicologierisico-inventarisatie en -evaluatie. Zeist: UitgeverijKerckeboschbv; 1995. Avlock RJ, Daston GP, DeRosa C, Fenner-Crisp P, Gray LE, Kaattari S, Lucier G, Luster M, Mac MJ, Maczka C, Miller R, Moore J, Rolland R, Scott G, Sheehan DM, Sinks T, Tilson HA. Research needs for the risk assessment of health and environmental effects of endocrine disruptors: a report of the U.S. EPA-sponsored workshop. Environ Health Perspect. 1996. pp. 715&ndash;740. [PMC free article] [PubMed] Crisp TM, Clegg ED, Cooper RL, Wood WP, Anderson DG, Baetcke KP, Hoffmann JL, Morrow MS, Rodier DJ, Schaeffer JE, Touart LW, Zeeman MG, Patel YM. Environmental endocrine disruption: an effects assessment andanalysis. Environ Health Perspect. 1998. pp. 11&ndash;56. [PMC free article] [PubMed] Vinggaard AM, Hnida C, Breinholt V, Larsen JC. Screening of selected pesticides for inhibition of CYP19 aromatase activity in vitro. Toxicol In Vitro. 2000;14:227&ndash;234. doi: 10.1016/S0887-2333(00)00018-7. [PubMed] [Cross Ref]. Hirsch KS, Weaver DE, Black LJ, Falcone JF, MacLusky NJ. Inhibition of central nervous system aromatase activity: a mechanism for fenarimol-induced infertility in the male rat. ToxicolApplPharmacol. 1987;91:235&ndash;245. doi: 10.1016/0041-008X(87)90104-9. [PubMed] [Cross Ref] Mason JI, Carr BR, Murry BA. Imidazole antimycotics: selective inhibitors of steroid aromatization and progesterone hydroxylation. Steroids. 1987;50:179&ndash;189. doi: 10.1016/0039-128X(83)90070-3. [PubMed] [Cross Ref] Tania Luthra, Rahul Agarwal, Mamidala Estari, Uma Adepally, Subhabrata Sen. A novel library of -arylketones as potential inhibitors of &alpha;-glucosidase: Their design, synthesis, in vitro and in vivo studies. Nature-Scientific Reports, 2017, 7(1), 1-13. DOI: 10.1038/s41598- 017-13798-y. Sanderson JT, Seinen W, Giesy JP, van den BM. 2-Chloro-s-triazine herbicides induce aromatase (CYP19) activity inH295R human adrenocortical carcinoma cells: a novel mechanism for estrogenicity? Toxicol Sci. 2000;54:121&ndash;127. doi: 10.1093/toxsci/54.1.121. [PubMed] [Cross Ref] You L, Sar M, Bartolucci E, Ploch S, Whitt M. Induction of hepatic aromatase by p,p&#39;-DDE in adult male rats. Mol Cell Endocrinol. 2001;178:207&ndash;214. doi: 10.1016/S0303-7207(01)00445-2. [PubMed] [Cross Ref] Andersen HR, Vinggaard AM, Rasmussen TH, Gjermandsen IM, Bonefeld-Jorgensen EC. Effects of currently used pesticides in assays for estrogenicity, androgenicity, and aromatase activity in vitro. ToxicolApplPharmacol. 2002;179:1&ndash;12. doi: 10.1006/taap.2001.9347. [PubMed] [Cross Ref] Haake J, Kelley M, Keys B, Safe S. The effects of organochlorine pesticides as inducers of testosterone and benzo[a]pyrene hydroxylases. Gen Pharmacol. 1987;18:165&ndash;169. [PubMed]

<strong>Abstract:</strong> The present cross-sectional study assessed the electrocardiographic (ECG) patterns of Professional male Heavy weightlifters compared to Untrained Subjects. The study recruited 80 Subjects comprising 40 Professional male heavy- weightlifters and 40 Untrained Subjects. The ECG recording of each subject was collected using the Aspel 12-channel ECG machine. The subject&#39;s demographic data as well as their anthropometric measurement and vital signs were also recorded. Quantitative data were subjected to descriptive and statistical analysis.&nbsp; The Statistical Package for Social Sciences (SPSS) version 20.00 software was used. It was observed that the limits of P-wave, QRS-complex, PR, and QT intervals were found to be within their normal limits. However, there is a prevalence of T- wave and ST-Segment abnormalities in Heavy&nbsp; weightlifters&nbsp; in Port Harcourt. Twenty-five (25%) of the Heavy Weightlifting Subjects presented with ST-Segment elevations. On the other hand, different forms of T-wave abnormalities were recorded amongst Heavy Weightlifting Subjects. Exactly 12.5%, 5% and 2.5% of the heavy weightlifters had inverted T-Wave, flat T-Wave, and hyperacute T-Wave respectively. The mean values of systolic and diastolic blood pressures (SBP and DBP) mean arterial pressure (MAP) and the pulse pressure (PP) of the Male Heavy&nbsp; weightlifters&nbsp; were all seen to be marginally (<em>p&lt;0.05</em>) lower than those of the Untrained Subjects. <strong>Keywords</strong><strong>:</strong> electrocardiogram, weightlifting, exercise, blood pressure. <strong>Title:</strong> COMPARATIVE ASSESSMENT OF ELECTROCARDIOGRAPHIC (ECG) PATTERNS OF PROFESSIONAL MALE HEAVY WEIGHTLIFTERS AND UNTRAINED SUBJECTS IN PORT HARCOURT <strong>Author:</strong> Tamuno-Opubo, Abiye Stanley, Rosemary Oluchi Austin-Asomeji, Iyingiala Badamosi, Adetomi Abiye, George Obiandu, Chibuike Bobojama, George Godwin <strong>International Journal of Novel Research in Interdisciplinary Studies</strong> <strong>ISSN 2394-9716</strong> <strong>Vol. 10, Issue 2, March 2023 - April 2023</strong> <strong>Page No: 32-38</strong> <strong>Novelty Journals</strong> <strong>Website: www.noveltyjournals.com</strong> <strong>Published Date: 02-March-2022</strong> <strong>DOI: https://doi.org/10.5281/zenodo.7691873</strong> <strong>Paper Download Link (Source)</strong> <strong>https://www.noveltyjournals.com/upload/paper/COMPARATIVE%20ASSESSMENT-02032023-3.pdf</strong>

In 1902, four American petrologists, C. Whitman Cross, Joseph P. Iddings, Louis V. Pirsson, and Henry S. Washington co-authored a lengthy paper in which they proposed an extremely complex, quantitative classification of igneous rocks. Taking advantage of developments in microscopic petrography, the theory of magmatic differentiation, and knowledge of the chemical composition of igneous rocks, the ‘CIPW’ classification marked a radical break with all previous igneous rock classification schemes such as those of Rosenbusch and Zirkel.The present paper is the first in a series that explores the genesis and conceptual development of the American quantitative classification. In 1893 Iddings posed a simple question to three young American petrologist friends, Cross, Pirsson, and George H. Williams, about the legitimacy of the use of the terms ‘porphyry’ and ‘porphyrite’. Henry Washington was to join the group later, but Williams was one of the original four. From this question there emerged an expanded discussion, conducted primarily via correspondence and mutual criticism of lengthy essays written by each of the four, dealing with larger questions of principles of classification and nomenclature. Any future classification, they agreed, should be based on igneous rock chemical composition and must reject geological age and geological occurrence as factors. Despite calls within the group for construction of a totally new igneous rock classification, the process evolved cautiously to a decision to publish a statement of general principles of igneous rock classification together with suggestions for changes in nomenclature for the benefit of petrologists. Eventually the project foundered because of health problems for Williams and the press of other obligations and interests on all four. In 1894, the project ground to a halt with the untimely death of Williams from typhoid fever.

is research aims to clearly understand the poetry structure and meaning of the song Di Na Mamolus Sandok Ngolu On. This research uses a descriptive analysis method with a qualitative approach. The work process carried out is observation, interviews, documentation. Research is carried out by collecting information through field research to obtain results which are processed into original data. The meaning of the lyrics of the song Di Na Mamolus Sandok Ngolu On is first, this also applies to every difficulty and suffering that occurs in our lives. Second, the things we learn through suffering, give us a unique ability to strengthen and comfort people. -people who are experiencing similar difficulties or suffering (2 Corinthians 1:4-5). Third, God provides comfort, not so that we are comfortable, but so that we can provide comfort to others. This song was created by George S. Schuler in 1924, has a 6/8 bar with a tempo of 54 with a basic note of C=do consisting of 24 bars. The song Di Na Mamolus Sandok Ngolu On is an opening song used by Protestants which has a 6/4 meter pattern with the basic note C=do having cross rhymes, namely a, a, b, a. The meaning of the song Di Na Mamolus Sandok Ngolu On is that the things we learn through suffering give us the ability to strengthen and comfort people who are experiencing difficulties or suffering.

Abstract Background Psychiatric patients often exhibit reduced medication adherence due to a lack of understanding, prejudice, and side effects of psychotropic drugs (Marrero et al., 2020). Aims &amp; Objectives This study aims to analyze the emotional valuation of medication by psychiatric patients and their caregivers through posts on internet communities. It seeks to understand the relationship between these sentiments and the medication and its side effects. Method Over a three-month period (from October 1, 2023, to December 31, 2023), posts from an internet community site (https://cafe.naver.com/koreanmania) used by psychiatric patients and caregivers were collected. The posts were web-scraped using the Python Selenium package, adhering to ethical web-scraping guidelines (robots. txt). The collected data was preprocessed to filter relevant information and reduce noise. Language and sentiment analysis were performed on the preprocessed data using the ChatGPT 3.5 turbo model. For statistical analysis of the data, particularly to assess the significance of associations between reported side effects and specific medications, the R programming language was employed. The automated analysis results were manually reviewed by psychiatrists, achieving an 88% concordance rate. Results A total of 9800 posts were collected, with 2522 specifically discussing medications. Of these, 1449 mentions referred to specific drugs, including aripiprazole (12.7%), quetiapine (7.73%), lithium (6.63%), escitalopram (5.38%), fluoxetine (5.24%), methylphenidate (4.83%), risperidone (4.55%), alprazolam (4.49%), and lorazepam (4.35%). The most commonly reported side effects were weight gain (including increase of appetite, 15.78%), numbness (12.3%), and sleep disturbance (9.11%), with olanzapine (p=0.02), quetiapine (p=0.02), mirtazapine (p=0.04), and lithium (p=0.04) showing significant associations with weight gain. Discussion &amp; Conclusion In this study, we examined online posts from psychiatric patients and caregivers, focusing on their experiences and perceptions of psychotropic medications and their side effects. Our analysis revealed that understanding and addressing the most frequent and distressing side effects, such as weight gain (Schwartz et al., 2004), is crucial for enhancing medication adherence in psychiatric patients. This study also underscores the importance of dispelling common misconceptions, further aiding adherence (Kalckreuth et al., 2014; Aref-Adib et al., 2016). Additionally, our use of ChatGPT to analyze and assess sentiments in a variety of real-world contexts highlights its potential as a significant tool for future medical data analysis and application (George et al., 2021). References 1)AREF-ADIB, G., O'HANLON, P., FULLARTON, K., MORANT, N., SOMMERLAD, A, JOHNSON, S. &amp; OSBORN, D. 2016. A qualitative study of online mental health information seeking behaviour by those with psychosis. BMC psychiatry, 16, 1-10. 2)GEORGE, A., JOHNSON, D., CARENINI, G., ESLAMI, A., NG, R. &amp;PORTALES-CASAMAR, E. 2021. Applications of aspect-based sentiment analysis on psychiatric clinical notes to study suicide in youth. AMIA Summits on Translational science Proceedings, 2021, 229. 3)KALCKREUTH, S., TREFFLICH, F. &amp;RUMMEL-KLUGE, C. 2014. Mental health related Internet use among psychiatric patients: a cross-sectional analysis. BMC psychiatry, 14, 1-11. 4)MARRERO, R. J., FUMERO, A., DE MIGUEL, A. &amp;PENATE, W. 2020. Psychological factors involved in psychopharmacological medication adherence in mental health patients: A systemic review. Patients Education and Counseling, 103, 2116-2131. 5)SCHWARTZ, T. L., NIHALANI, N., JINDAL, S., VIRK, S. &amp;JONES, N. 2004. Psychiatric medication-induced obesity: a review. Obesity Reviews, 5, 115-121.

Text kanonickej vizitácie sleduje farnosti Užhorod (Ужгород), Vojnatina, Onokovce (Оноківці), Senné, Pavlovce nad Uhom, Ratovce (Ратівці), Jovra (Ёр, dnes Сторожниця) a Ruská.V Užhorode bol chrám zasvätený svätému Jurajovi, ktorý sa nachádzal na soľnej ulici. Vo vnútri chrámu boli umiestnené tri väčšie a dva menšie oltáre. Väčšie oltáre boli zasvätené svätému Ladislavovi, sv. Štefanovi, sv. Jurajovi a sv. Panne Márii. Menšie oltáre boli zasvätené sv. Alžbete, sv. Kataríne a sv. Jánovi Nepomuckému so svätou Rozáliou a Kristom v uprostred.Farnosť Jovra mala farský chrám zasvätený Panne Márii Kráľovnej. Chrám bol murovaný a mal tri oltáre. Prvý bol zasvätený Panne Márii, menšie boli zasvätené sv. Barbore a sv. Šebastiánovi. V Jovre vyučoval učiteľ Michal Kertés, ktorý bol platený v naturáliách a jedným florénom.Farnosť Ratovce mala murovaný chrám v hroznom stave. Chrám sa rekonštruoval v roku 1734 a oltár bol bez obrazu či patrocínia. Správcom farnosti bol Ján Enickej jeho rekatolizačná činnosť bola zameraná na modlenie litánii s umiestnení obyvateľmi v ich jazyk.Farnosť Ruská sa nachádzala v nábožensky zmiešanom regióne. Chrám bol murovaný z tehál nachádzali sa v ňom dva oltáre. Tretí oltár sa začal vyrábať, mal byť zasvätený sv. Krížu. Farnosť spravoval Andrej Moštenský, ktorý sa modlí s miestnymi v ich jazyku modlitby ako Otče náš, ruženec, krédo alebo litánie.Vo farnosti Pavlovce nad Uhom stál murovaný chrám s jedným oltárom. Oltár nemal patrocínium, preto nemôž chrám v minuloti používali kalvíni. Správcom miestnej farnosti bol Mikuláš Berekovič.Farnosť Senné spravoval Ján Ziffian. Miestny chrám bol tehelný a nachádzali sa v ňom tri oltáre. Hlavný bol s titulom Nanebovzatia Panny Márie. Na menšom oltári boli na okrajoch vyobrazenia evanjelistov a v strede sa nachádzali obraz sv. Panny Márie, sv. Juraja a Baránka Božieho. Ako tretí oltár bol zasvätený sv. Jurajovi. Titul chrámu bol sviatok Navštívenia Panny Márie.Onokovská farnosť sa nachádzala severnej od Užhorodu. Chrám v Onokovciach bol drevený, zasvätený Nanebovzatiu Panny Márie. Patrocínium chrámu bolo totožné s titulom chrámu, ďalšie obrazy sa v kostole nenašli. Farnosť spravoval Sebastián Kašaj, ktorý mal 40 rokov. V jeho okolí boli hlavne obyvatelia gréckeho rítu.Najšpecifiskejšou farnosťou bola Vojnatina. Farnosť bola misijným územím, kde pôsobil Ján Patkovič. Medzi Užhrorodom a Michalovcami, bolo veľké množstvo rozbitých alebo zdevastovaných chrámov. Ako prvý bol obnovených chrám vo Vojnatine. Chrám bol tehelný, vo vnútri sa nachádzal len jeden oltár, ktorý bol zasvätený sv. Krížu a bol presunutý z Užhorodu.The canonical visitation focused on parishes Uzhgorod (Ужгород), Vojnatina, Onokovce (Оноківці), Senné, Pavlovce nad Uhom, Ratovce (Ратівці), Jovra (Ёр, today Сторожниця), and Ruská.In Uzhgorod, there was a temple dedicated to Saint George, which was situated on the salt street and inside were three bigger and two smaller altars. The bigger altars were dedicated to Saint Ladislaus and Saint Stephen, Saint George, and Saint Mary the Virgin, while the smaller altars were dedicated to Saint Elisabeth and Saint Catherine, Saint John of Nepomuk with Saint Rosalie, and Christ in the middle.The parish Jovra had a parish temple dedicated to Virgin Mary Queen. The local temple was from brick and had three altars. The first one was dedicated to Virgin Mary, the smaller ones were dedicated to Saint Barbara and Saint Sebastian. In Jovra, there was a teacher named Michal Kertés, who was paid in kind and with one florin.The parish Ratovce had a brick temple in a horrible condition. The temple was being under reconstruction in the year 1734 and there was an altar without a picture or a patron. The administer of the parish was John Enickei, his re-Catholic activity was focused on praying litany with the locals in their language.The parish Ruská was located on a confessionally mixed territory. The temple was made from brick and there were two altars. The third one was being produced, it should have been dedicated to Holy Cross. The parish was administered by Andrej Moštenský, who prayed prayers such as Our Father, Hail Mary, I believe in God, or Litany with the locals in their language.In the parish Pavlovce nad Uhom, there was a brick temple with one altar. The altar did not have a patrocinium since the temple had been used by the Calvinists. The administer of the local parish was Nicolas Berekovič.The parish Senné was administered by John Zaffian. The local temple was made from brick and inside there were three altars. The main was with the title of Assumption of Virgin Mary. The smaller altar had depictions of Evangelists in corners, and in the middle, there was a picture of Virgin Mary, Saint George, and Lamb of God. The third altar depicted John the Baptist. The title of the temple was Visitation of the Virgin Mary’s holiday.Onokov’s parish was located north of Uzhgorod. The temple in Onokovce was made from wood and dedicated to the Assumption of Virgin Mary. The title of the temple was depicted on an altar, other altars or pictures were not found in the church. The parish was administered by Sebastian Kašaj, who was 40 years old. In his surroundings, there were mainly presbyters orientated to Greek ceremony.The most specific parish was Vojnatina. The parish was a mission village where John Patkovič worked. Between Uzhgorod and Michalovce, there was a big amount of broken or devastated temples. As the first one, the temple in Vojnatina was renewed. The temple was from brick and inside there was one altar with the title of Holy Cross brought from Uzhgorod.

<strong>Background:</strong>&nbsp;Chronic kidney disease (CKD) is a widespread and multifaceted condition that affects millions of individuals globally. While its impact on renal function is well-documented, the intricate relationship between CKD and cutaneous manifestations has garnered increasing attention in recent years.&nbsp;<strong>Aims:&nbsp;</strong>To study various patterns of cutaneous manifestations in patients with Chronic Kidney Disease and to compare cutaneous manifestations in patients with and without chronic kidney disease.&nbsp;<strong>Materials &amp; Methods:&nbsp;</strong>It is a cross sectional descriptive study conducted over 12 months in the department of dermatology and nephrology, King George hospital, Visakhapatnam, a total of 120 patients were included in the study, a comprehensive history, detailed examination, and specific investigations such as skin biopsy, culture and sensitivity for bacterial infections, Gram&rsquo;s stain, potassium hydroxide mount, and fungal culture were done wherever clinically indicated.&nbsp;<strong>Results:&nbsp;</strong>Majority of patients (39.2%) belong to age group of 41 to 50 years, with male predominance. 31.7% (38) patients complained of pruritus, Xerosis was seen in 26.7%(32) of patients, The proportion of pigmentation among patients with CKD is 8.3% (10), 55.3% of patients with pruritus were on dialysis, 59.4% of patients with xerosis were on dialysis, 40% of patients with pigmentation were on dialysis.&nbsp;<strong>Conclusion:&nbsp;</strong>Pruritus was the most common manifestation in CKD patients followed by xerosis, ecchymosis and pigmentary changes. There is no significant difference in cutaneous manifestations in patients with and without dialysis. &nbsp; &nbsp;

<strong>Aim:</strong>&nbsp;The purpose of this study to determine the prevalence of dermatological lesions in patients with diabetic retinopathy.&nbsp;<strong>Methods:</strong>&nbsp;This cross-sectional study was done the Department of Ophthalmology, King George&rsquo;s Medical University (KGMC), Lucknow, UP, India, for 10 months. 130 patients with diabetic retinopathy having diabetes mellitus of at least 5 years duration, aged between 30-67 years, were included in this study. The dermatological examination was done by a dermatologist under proper day light and if needed, using handheld magnifying lens. Examination of the retina was done by an Ophthalmologist using indirect ophthalmoscopy of dilated fundus, fundus photo, fundus fluorescein angiography and optical coherence tomography of the macula.&nbsp;<strong>Results:</strong>&nbsp;Among 130 diabetic patients, 12(9.23%) had Very Mild Non-Proliferative Diabetic Retinopathy (NPDR), 42(32.31%) had Mild NPDR, 49(37.69%) had Moderate NPDR, 16(12.31%) had Severe NPDR, 11(8.46%) had Proliferative Diabetic Retinopathy (PDR) and 52(40%) had Clinically Significant Macular Edema (CSME). 102 among 130 DR patients had different types of dermatological lesions, the prevalence being 78.46%. Dermatological lesions among poor glycemic control DM patients had a prevalence of 55.38% which was higher as compared to 34.62% among good glycemic control DM patients. 55(42.31%) patients had diabetic dermopathy, 40(30.77%) had Xerosis, 34(26.15%) had IGH, 30(23.84%) patients had Icthyosis, 9(6.92%) patients had Intertrigo, 7(5.38%) patients had Tinea Versicolor, 6(4.62%) patients had Chronic Paronychia and 4(4.62%) patients had Tinea Unguium.&nbsp;<strong>Conclusion:</strong>&nbsp;Prevalence of Dermatological lesions in Diabetic Retinopathy patients was 42.31%. &nbsp; &nbsp; &nbsp;

Dear Readers, It gives me great pleasure to announce the sixth regular issue of 2024. In this issue, 6 papers cover various topical aspects of computer science by 19 authors from 7 countries: Brazil, Chile, France, India, Saudi Arabia, Tunisia, and Turkey. In an ongoing effort to further strengthen our journal, I would like to expand the editorial board: If you are a tenured associate professor or above with a strong publication record, you are welcome to apply to join our editorial board. We are also interested in high-quality proposals for special issues on new topics and trends. As always, I would like to thank all authors for their sound research and the editorial board and our guest reviewers for their extremely valuable review effort and suggestions for improvement. These contributions, together with the generous support of the consortium members, help to maintain the quality of our journal.&amp;nbsp; In this regular issue, I am very pleased to introduce the following 6 accepted articles: George Marsicano, Edna Dias Canedo, Glauco V. Pedrosa, Cristiane S. Ramos, and Rejane M. da C. Figueiredo from Brazil look in their study into digital transformation of public services in a startup-based environment by 23 focus groups and 175 participants in total. Mauricio Solar and Pablo Aguirre from Chile discuss their research on 3D chest CT processes applying a ResNet-50 model to which a new dimension of information has been added, namely a simple autoencoder. In a collaborative work between researchers from Tunisia and France, Rakia Saidi, Fethi Jarray, and Didier Schwab propose in their article a cross-encoder neural network (Cross-BERT-GRU) to deal with the semantic similarity of Arabic sentences that benefits from both the strong contextual understanding of BERT and the sequential modeling capabilities of GRU. Also in a collaborative research between institutions from Tunisia and Saudi Arabia, Nozha Jlidi, Sameh Kouni, Olfa Jemai, and Tahani Bouchrika present their research on MediaPipe with GNN for human activity recognition. G.V.Vidya Lakshmi and S. Gopikrishnan from India look into missing values research for the IoT domain and in particular present IMD-MP technique that improves imputation accuracy for big data analysis in IoT applications based on spatial-temporal correlations. Last but not least, F. Didem Alay, Nagehan &amp;#304;lhan, and M. Tahir G&amp;uuml;ll&amp;uuml;o&amp;#287;lu address in their article a comparative study of data mining methods for solar radiation and temperature forecasting models. Enjoy Reading Cordially,&amp;nbsp; Christian G&amp;uuml;tl, Managing Editor Graz University of Technology, Graz, Austria

Dear Readers, It gives me great pleasure to announce the sixth regular issue of 2024. In this issue, 6 papers cover various topical aspects of computer science by 19 authors from 7 countries: Brazil, Chile, France, India, Saudi Arabia, Tunisia, and Turkey. In an ongoing effort to further strengthen our journal, I would like to expand the editorial board: If you are a tenured associate professor or above with a strong publication record, you are welcome to apply to join our editorial board. We are also interested in high-quality proposals for special issues on new topics and trends. As always, I would like to thank all authors for their sound research and the editorial board and our guest reviewers for their extremely valuable review effort and suggestions for improvement. These contributions, together with the generous support of the consortium members, help to maintain the quality of our journal. In this regular issue, I am very pleased to introduce the following 6 accepted articles: George Marsicano, Edna Dias Canedo, Glauco V. Pedrosa, Cristiane S. Ramos, and Rejane M. da C. Figueiredo from Brazil look in their study into digital transformation of public services in a startup-based environment by 23 focus groups and 175 participants in total. Mauricio Solar and Pablo Aguirre from Chile discuss their research on 3D chest CT processes applying a ResNet-50 model to which a new dimension of information has been added, namely a simple autoencoder. In a collaborative work between researchers from Tunisia and France, Rakia Saidi, Fethi Jarray, and Didier Schwab propose in their article a cross-encoder neural network (Cross-BERT-GRU) to deal with the semantic similarity of Arabic sentences that benefits from both the strong contextual understanding of BERT and the sequential modeling capabilities of GRU. Also in a collaborative research between institutions from Tunisia and Saudi Arabia, Nozha Jlidi, Sameh Kouni, Olfa Jemai, and Tahani Bouchrika present their research on MediaPipe with GNN for human activity recognition. G.V.Vidya Lakshmi and S. Gopikrishnan from India look into missing values research for the IoT domain and in particular present IMD-MP technique that improves imputation accuracy for big data analysis in IoT applications based on spatial-temporal correlations. Last but not least, F. Didem Alay, Nagehan &#304;lhan, and M. Tahir G&uuml;ll&uuml;o&#287;lu address in their article a comparative study of data mining methods for solar radiation and temperature forecasting models. Enjoy Reading Cordially, Christian G&uuml;tl, Managing Editor Graz University of Technology, Graz, Austria

<strong>Abstract:</strong> <strong>Background: </strong>The significant reason for anguish as well as incapacity is chronic obstructive pulmonary disease (COPD). Activities of daily living might be relentlessly curbed among patients with COPD and appraisal needs evaluation regarding influence of infirmity and detriments on day-to-day living. The primary objective was to know the daily activity associated quality of life in COPD adults. The secondary objective was to analyze demographical profile, such as gender and age of COPD subjects as well as evaluate the physical activity related breathlessness in COPD patients. <strong>Methodology: </strong>This study was executed at Gulab Devi Chest Hospital. We used cross sectional study design to collect the data. For collecting the statistics of 150 subjects aged 40-60 years of either gender Saint George&rsquo;s Questionnaire was liable. It included the patient&rsquo;s biodata, effect of COPD on physical activities and limitations in routine work. <strong>Results: </strong>The ages of 150 COPD patients selected were between 40 and 60 years. Patients were classified into two categories on the basis of disease severity according to GOLD criteria 71 (47.3%) were with moderate severity and 79 (52.7%) were with severe severity. 113 (75.3%) patients were smokers while 37 (24.7%) patients were non-smokers. 110 (73.3%) COPD patients were active smokers in comparison 40 (26.7%) COPD patients were passive smokers. COPD patients with current smoking status were 79 (52.7%) and with past smoking status were 71 (47.3%). 19 (12.7%) COPD patients felt breathlessness while sitting and lying. 53(35.3%) COPD patients felt breathless while getting washed or dressed. 85(56.7%) COPD patients felt breathless while walking around the home. 114 (96%) COPD patients discerned breathlessness while walking up a flight of stairs. 145 (96.7%) COPD patients had breathlessness while playing sports or games. 146 (97.3%) COPD patients experienced difficulty in breathing during activities like carrying load. 88 (58.7%) COPD patients discerned breathlessness during entertainment or recreation. 88 (58.7%) COPD patients discerned breathlessness during entertainment or recreation. 7 (4.7%) COPD patients felt breathlessness while moving from bed or chair. <strong>Conclusion: </strong>As with the progression of COPD impairment in activities become worse due to breathlessness causing decline in patient&rsquo;s ability making them unable to complete their task to fulfill the needs of life and ultimately become bed bound due to shortness of breath.

<strong>Introduction:</strong>&nbsp;The COPD Assessment Test (CAT) is a simple method for assessing the impact of COPD on the patient`s health which is not validated with North African COPD patients. <strong>Objective:</strong>&nbsp;To determine the relationship between the CAT score and the SGRQ, anthropometric, dyspnea, severity of airflow obstruction and Global Initiative for Chronic Obstructive Lung Disease (GOLD) stages in stable COPD patients. <strong>Material and Methods:</strong>&nbsp;It is a cross-sectional observational study. It consists of a convenience sample of COPD and Smokers subjects aged more than 30 years. Dyspnea was evaluated according to the modified British medical research council (mMRC) 4). Arabic versions of the SGRQ and CAT questionnaires were used. Spirometry was performed in accordance with international standards. Obstructive ventilator defect (OVD) grades and GOLD grades were identified. <strong>Results:</strong>&nbsp;A total sample of 150 (121 COPD) was collected. A negative correlation was found between CAT score and anthropometric and all functional parameters in the total sample. Correlations between CAT score and mMRC score, pulmonary age and SGRQ score were found in COPD group (p&lt;0.01). CAT score correlated with OVD and GOLD grades, severe COPD (GOLD 3 and 4) had higher CAT scores. <strong>Conclusion:</strong>&nbsp;There is a strong relationship between CAT score and clinical and functional COPD components. <strong>Impact of this research on clinical medicine and basic science:</strong>&nbsp;COPD is a complex disease with multiple consequences which can impede the quality of life of patients. The latter can be evaluated by specific questionnaires. The most used questionnaire is St. George&rsquo;s Respiratory Questionnaire (SGRQ). However, this health status measure is long and not practical for clinical routine use. Therefore, recently a new simple system evaluating health status was developed. It is the COPD Assessment Test (CAT), which was approved, in its French, English and Arabic version. It is a simple method for assessing the impact of COPD on the patient`s health. CAT is composed of only eight questions and a key is not needed to calculate a score. To our own knowledge, there are no studies about CAT scoring in and its relation with clinical and respiratory function characteristics in North Africa. <strong>Keywords:</strong>&nbsp;COPD- CAT score- SGRQ-FEV1- Spirometry

Abstract Targeting protein kinases is an attractive strategy in cancer therapy owing to their importance in cell signaling pathways. Tousled-like kinases (TLKs) are associated with chromosomal integrity, DNA replication, and repair. However, the dysregulation of these genes can give rise to different aberrations. The activity of TLK1, a human isoform of TLK, is found to be attenuated in the case of prostate cancer and breast cancer, as it can phosphorylate many proteins of the DNA Damage Response (DDR) pathway, hence making TLK1 a novel druggable target. To date, phenothiazines-which are known antipsychotic drugs, are the only class of inhibitors reported against TLK1. Our work focuses on developing a new class of TLK1 inhibitors to broaden the spectrum of understanding TLK1 inhibition. As an approach, we designed, synthesized, and validated indole-based molecules with potent TLK1 inhibition via in-silico studies. We further explored the synthesized inhibitors to understand their inhibition against recombinantly purified TLK1 in the presence of its different substrates. Also, the cell viability of these inhibitors was examined against breast cancer and prostate cancer. We found that the inhibitors are more potent in prostate cancer cell lines, as observed by the lowered downstream phosphorylation levels of TLK1 substrates in those cells. The in-vitro, cell, and docking studies imply that the newly designed inhibitors have better potency against TLK1 than its reported inhibitors. We anticipate that our step towards exploring a new class of potent TLK1 inhibitors would aid in elevating the therapeutics in a combinatorial approach to existing prostate cancer therapy. References: 1. Cohen, P., Cross, D. and Jänne, P.A. Kinase drug discovery 20 years after imatinib: progress and future directions. 2021, Nat Rev Drug Discov 20, 551–569. 2. Kirubakaran, S; Thiruvenkatam, V; and George, J. "An indole-based kinase inhibitor and a process for its preparation", Indian Patent Office, Patent Application No.: 202121048608, 2021, Oct. 25. 3. Johnson, D., J. Hussain, S. Bhoir, V. Chandrasekaran, P. Sahrawat, T. Hans, M. I. Khalil, A. De Benedetti, V. Thiruvenkatam, and S. Kirubakaran. Synthesis, kinetics and cellular studies of new phenothiazine analogs as potent human-TLK inhibitors. 2023, Org. Biomol. Chem, Advance article, 10.1039/D2OB02191A. 4. Singh, V., Bhoir, S., Chikhale, R.V., Hussain, J., Dwyer, D., Bryce, R.A., Kirubakran, S. and De Benedetti, A. Generation of Phenothiazine with Potent Anti-TLK1 Activity for Prostate Cancer Therapy. 2020, Iscience, 23, 101474. Citation Format: Delna Johnson, Sivapriya Kirubakaran, Vijay Thiruvenkatam. Investigation of indole-based molecules as a new class of TLK1 inhibitors in prostate cancer therapy [abstract]. In: Proceedings of the AACR-NCI-EORTC Virtual International Conference on Molecular Targets and Cancer Therapeutics; 2023 Oct 11-15; Boston, MA. Philadelphia (PA): AACR; Mol Cancer Ther 2023;22(12 Suppl):Abstract nr C154.

The article reveals a new way of interpreting the last words of Shakespeare’s Richard III on the Bosworth battlefield (5.4.7, 13). As evidenced by numerous parodies and anecdotes the phrase became an idiom in the age of Shakespeare, and in the 19th century Russian translations has survived metamorphoses ranging from the fairy “half the kingdom” to the alternative “the whole kingdom” for a horse. The available interpretations in scientific editions don’t clarify the expression. It is absent in historical (Hall, Holinshed) and possible literary (Richardus Tertius, True Tragedy) sources, but corresponds to the logic of character and actions of Shakespeare’s Richard. We traced the development of the “white horse” motive, identified its heraldic symbolism and the leading biblical allegory associated with the image of the victor in the battle for the world (Rev. 19: 11, 16), as well as the playwright’s emphasis on the tyrant’s progressing madness. The revealed increase in biblical lexis (“irons of wrath,” “cast,” etc) and imagery (non-sunrise, the paradox of “George” and “dragon”), the symbolism of the stage space (set in accordance with the iconography of the Crucifixion and the Last Judgment) allow us to read the denouement of the cross-cutting theme of the fight between “the world” and “nothing” (1.2.240) in spirit and tradition of religious play. Richard’s “wager” takes the play beyond the boundaries of the genres codified by the Folio (Histories and Tragedies) and raises it to a mystery play, demonstrating the last battle in Heaven. Paradoxically, the first Russian translator of the play, S. Sergievsky, at the end of the 18th century most accurately succeeded in conveying the meaning of the “bet,” following the French translation by Pierre Antoine de La Place.

Introduction. The most frequent clinical outcomes in sarcoidosis patients are typically focused on the objective measurements of functions of the involved organs, but, generally, they do not take into account the individual perception of patients? everyday functioning. The aim of this study was to determine the type of association between the subjective disease outcomes and other objective conventional parameters in patients with sarcoidosis. Material and Methods. In the cross-sectional study including 172 sarcoidosis patients (122 females), quality of life was measured by a generic instrument, i.e. fifteen-dimensional measure of health-related quality of life together with a respiratory specific instrument, i.e. St George?s Respiratory Questionnaire; symptoms of fatigue were measured by Fatigue Scale and dyspnea was measured by the Basal Dyspnea Index. Body-mass index and the course of the disease (acute vs. chronic) were also evaluated. Pulmonary function was assessed by spirometry. Results. Acute sarcoidosis was present in 48 (28%) patients. Mean body mass index was 27.01?5.2. Only 20 (12%) patients had lower forced expiratory volume in one second values (&lt;80%) that indicated the existance of obstructive ventilatory impairment. Multivariate linear regression analysis revealed that body mass index, clinical course of disease and spirometric parameter forced expiratory volume in one second were the significant predictors (R2=0.929, p&lt;0.01) of sarcoidosis related fatigue (B=0.061, B=0.406, B=0.452; respectively). Body mass index and forced expiratory volume in one second were the only parameters that significantly predicted both patients? quality of life (R2=0.932; B=0.017, B=0.263) and dyspnea (R2=0.847; B=0.025, B=0.668). Conclusions. It is important to measure both subjective patient-reported outcomes and objective disease parameters in sarcoidosis since they represent different aspects of the disease. All applied measuring instruments for the examined subjective outcomes demonstrated good measuring properties.

Статья посвящена вопросу составления списков уроженцев Змиевского уезда Харьковской губернии Российской империи, принимавших участие в Первой мировой войне. На основе архивных документов и фотографий авторы установили фамилии, имена и отчества более ста змиевцев-участников Великой войны 1914&ndash;1918 гг.

BackgroundNo published studies have assessed the perspectives of people with RA (pts) on disease-related lab testing and its role in treatment decision-making.ObjectivesOur objective was to examine how pts perceive RA-related lab testing and pts’ perceived utility of a blood test to predict treatment response to a new RA medication.MethodsA cross-sectional survey was developed with input from pts, rheumatologists, researchers, and pt advocates. Members of ArthritisPower with a self-reported physician diagnosis of RA were invited to participate in the online survey which included questions related to reasons for lab testing, plus a choice-based conjoint analysis (CA) exercise to determine how pts value different attributes of a blood test to predict treatment response. For the CA, 48 different hypothetical test characteristics (bundles) were created based on different combinations of 3 test attributes (Accuracy, Wait Time, Cost), each with 3-4 levels. Each pt responded to 5 questions asking them to choose between two of these hypothetical tests, randomized by the Qualtrics survey platform.ResultsDuring May-June 2022, 405 RA pts completed the survey, of whom 86.7% were female, 89.9% white, mean age of 57.9 (SD 11.6) years. Pts were on the following medications: 75.1% csDMARD, 53.6% bDMARD, 17.8% tsDMARD (not mutually exclusive). Most pts perceived their doctor orders laboratory work to check for active inflammation (85.9%) or assess side effects of medications (81.2%). Pts reported that their rheumatologists most often ordered complete blood counts, liver function tests, CRP and ESR to monitor RA, and felt CRP was most helpful to themselves in understanding their disease activity (Table 1). Most pts worried their current RA medication would stop working (91.4%) and they would waste time trying an RA medication that may not work for them (81.7%). If pts were required to change RA treatments in the future, a majority (89.2%) would be very/extremely interested in a blood test that could help predict whether such new medication would be effective. Highly accurate test results (improving chance RA medication will work from 50% to 85-95%) were more important to pts than low cost (&lt;$20) or minimal wait time (&lt;7 days) (Figure 1).ConclusionMost pts consider RA-related blood work to be important for monitoring active inflammation and medication side effects, and felt CRP was most helpful in understanding disease activity. For a test predicting treatment response, patients valued accuracy over cost or wait time.Table 1.Patient Perceptions of Utility of RA-Related Blood Work, n=405Used by Physicians To Monitor RAan (%)Used by Physicians When Considering Changing Medicationsbn (%)Useful for Patients to Understand Disease Activitycn (%)Complete blood count (CBC)322(79.5)170(42.0)128(31.6)Liver function tests, kidney tests and/or complete metabolic panel312(77.0)174(43.0)140(34.6)C-reactive protein (CRP)269(66.4)162(40.0)197(48.6)Erythrocyte sedimentation rate (ESR)238(58.8)181(37.3)174(43.0)Vitamin levels (e.g. vitamin D, iron, calcium)118(29.1)66(16.3)63(15.6)None/I don’t know42(10.3)197(48.7)123(30.4)Vectra DA (multi-biomarker disease activity)25(6.2)35(8.6)57(14.1)aPatients were asked to select which test(s) their rheumatologist orders for routine RA monitoringbPatients were asked to select which test(s) their rheumatologist orders when considering changing RA medicationscPatients were asked to select which test(s) they consider most useful to understand their RA disease activityBolded values are top selections for each columnAcknowledgementsFunding support was provided by Scipher Medicine Corporation. The authors wish to thank ArthritisPower research registry members who participated in the study.Disclosure of InterestsW. Benjamin Nowell Grant/research support from: Grant/research support from AbbVie, Amgen, Janssen and Scipher Medicine., Shilpa Venkatachalam: None declared, Kelly Gavigan: None declared, Michael George Consultant of: Personal fees from AbbVie, Grant/research support from: Research support from Glaxo-Smith Kline (GSK), Johanna Withers Employee of: Employee of Scipher Medicine Corporation, Laura Stradford: None declared, Esteban Rivera: None declared, Jeffrey Curtis Speakers bureau: See Consultant, Paid instructor for: See Consultant, Consultant of: Consulting fees from AbbVie, Amgen, Bendcare, BMS, Corrona, Eli Lilly and Company, Gilead, GSK, Janssen, Novartis, Pfizer, Sanofi, Scipher Medicine, and UCB, Grant/research support from: Research grants from AbbVie, Amgen, Bendcare, BMS, Corrona, Eli Lilly and Company, GSK, Janssen, Novartis, Pfizer, Sanofi, Scipher Medicine, and UCB.

<strong>Aim:</strong>&nbsp;The aim of the present study was to assess the awareness and knowledge of Diabetic retinopathy among Diabetic patients.&nbsp;<strong>Methods:</strong>&nbsp;This was a descriptive, cross sectional, non-randomized, questionnaire-based study conducted in the Department of Ophthalmology, King George&rsquo;s Medical University (KGMC), Lucknow, UP, India, for 1 year. A knowledge attitude practice questionnaire was prepared and pretested in a sample group of representative population. The response was analyzed as to whether the questions were understood or not. Resident doctors were trained in administering questionnaire. Diabetic patients were given questionnaires at retina clinic and filled in the presence of residents.&nbsp;<strong>Results:</strong>&nbsp;Out of the 150 patients, 82(54.67%) had no knowledge of diabetic retinopathy compared to 68 (45.33%) who had knowledge. This was statistically significant with p value &lt;0.001. Knowledge was more in age group less than 25 years (66.67%) and least in 35 to 45 age group (47.83%) which was statistically significant with p value &lt;0.001. Patients in the upper socioeconomic group had more knowledge about diabetic retinopathy (57.14%) which was statistically significant with a p value of 0.001. About 73.53 % of individuals in knowledge group had right attitude which was significantly higher than non-knowledge group (57.32%) with a p value &lt;0.001. Regarding source of information, 50% of patients in knowledge group got information about diabetic retinopathy from physicians, 12% from eye specialists, 10.67% from reading books, 10.67% from various media and 26.67% from other sources like family and friends. About 20.59% in knowledge group had practice of visiting ophthalmologist for eye check-up which was significantly higher than non-knowledge group with a p value &lt;0.001.&nbsp;<strong>Conclusion:</strong>&nbsp;we concluded that the Increasing knowledge about diabetic retinopathy through awareness campaigns can improve attitude &amp; practice. Early detection &amp; timely intervention can help in preventing sight threatening complications. &nbsp; &nbsp; &nbsp;

Abstract With an increasing number of positive lung cancer screening trials and the growing utilization of low dose CT screening, the detection of indeterminate pulmonary nodules is an important clinical problem. A biomarker that will be able to differentiate between benign andmalignant nodules would help to accelerate diagnosis and reduce unnecessary and invasive procedures. Here, we investigated the utility of quantitative radiomics to predict malignancy of small pulmonary nodules. Data including cancer status, age, gender, smokingstatus and CT radiomics data, from 242 patients accrued from the Detection of Early Lung Cancer Among Military Personnel (DECAMP1) consortium was used. DECAMP1 is a prospective study of 500 current or former smokers with indeterminate pulmonary nodules (0.7-3.0 cm). A total of 446 quantitative radiomic features were extracted from CT images of each patient. For the prediction models, various feature selection methods and machine learning algorithms including Random Forest, Gradient Boosting Machine and Support Vector Machine were used. Data was split into train and test set with tenfold cross-validation.Models were evaluated using; Accuracy, Sensitivity, Specificity and Area under the curve - a receiver operating characteristic curve (AUC-ROC). In terms of predictive performance, the AUC value was 0.64 (95% CI: 0.50-0.78) for the clinical model and 0.77 (95% CI: 0.64-0.90) for the radiomics model. Adding clinical features to the radiomics model (gender, age, smoking status) did not improve the model. We have also investigated the slice thickness and scanner (PET vs PET-CT) variables on the models’ performance and saw a modest improvement of the AUC values when using more homogenous data. In this study, we showed the potential of radiomics for lung cancer prediction in DECAMP1.For future work, we are planning to test whether incorporating bronchial gene expression data improves lung cancer detection and to validate these findings in separate, independent cohorts. Citation Format: Kate M. Bloch, Xingyi Shi, Fenghai Duan, George R. Washko, Avrum Spira, Denise R. Aberle, Raul S. Estepar, Ehab Billatos, Marc E. Lenburg, on behalf of the DECAMP Investigators. Predicting malignancy in indeterminate pulmonary nodules using quantitative CT imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 6392.

-Stanley L. Engerman, B.W. Higman, Slave populations of the British Caribbean, 1807-1834. Baltimore: The Johns Hopkins University Press, Johns Hopkins Studies in Atlantic History and Culture, 1984. xxxiii + 781 pp.-Susan Lowes, Gad J. Heuman, Between black and white: race, politics, and the free coloureds in Jamaica, 1792-1865. Westport CT: Greenwood Press, Contributions in Comparative Colonial Studies No. 5, 1981. 20 + 321 pp.-Anthony Payne, Lester D. Langley, The banana wars: an inner history of American empire, 1900-1934. Lexington KY: University Press of Kentucky, 1983. VIII + 255 pp.-Roger N. Buckley, David Geggus, Slavery, war and revolution: the British occupation of Saint Domingue, 1793-1798. New York: The Clarendon Press, Oxford University Press, 1982. xli + 492 pp.-Gabriel Debien, George Breathett, The Catholic Church in Haiti (1704-1785): selected letters, memoirs and documents. Chapel Hill NC: Documentary Publications, 1983. xii + 202 pp.-Alex Stepick, Michel S. Laguerre, American Odyssey: Haitians in New York City. Ithaca and London: Cornell University Press, 1984. 198 pp-Andres Serbin, H. Michael Erisman, The Caribbean challenge: U.S. policy in a volatile region. Boulder CO: Westview Press, 1984. xiii + 208 pp.-Andres Serbin, Ransford W. Palmer, Problems of development in beautiful countries: perspectives on the Caribbean. Lanham MD: The North-South Publishing Company, 1984. xvii + 91 pp.-Carl Stone, Anthony Payne, The politics of the Caribbean community 1961-79: regional integration among new states. Oxford: Manchester University Press, 1980. xi + 299 pp.-Evelyne Huber Stephens, Michael Manley, Jamaica: struggle in the periphery. London: Third World Media, in association with Writers and Readers Publishing Cooperative Society, 1982. xi + 259 pp.-Rhoda Reddock, Epica Task Force, Grenada: the peaceful revolution. Washington D.C., 1982. 132 pp.-Rhoda Reddock, W. Richard Jacobs ,Grenada: the route to revolution. Havana: Casa de Las Americas, 1979. 157 pp., Ian Jacobs (eds)-Jacqueline Anne Braveboy-Wagner, Andres Serbin, Geopolitica de las relaciones de Venezuela con el Caribe. Caracas: Fundación Fondo Editorial Acta Cientifica Venezolana, 1983.-Idsa E. Alegria-Ortega, Jorge Heine, Time for decision: the United States and Puerto Rico. Lanham MD: North-South Publishing Co., 1983. xi + 303 pp.-Richard Hart, Edward A. Alpers ,Walter Rodney, revolutionary and scholar: a tribute. Los Angeles: Center for Afro-American Studies and African Studies Center, University of California, 1982. xi + 187 pp., Pierre-Michel Fontaine (eds)-Paul Sutton, Patrick Solomon, Solomon: an autobiography. Trinidad: Inprint Caribbean, 1981. x + 253 pp.-Paul Sutton, Selwyn R. Cudjoe, Movement of the people: essays on independence. Ithaca NY: Calaloux Publications, 1983. xii + 217 pp.-David Barry Gaspar, Richard Price, To slay the Hydra: Dutch colonial perspectives on the Saramaka wars. Ann Arbor MI: Karoma Publishers, 1983. 249 pp.-Gary Brana-Shute, R. van Lier, Bonuman: een studie van zeven religieuze specialisten in Suriname. Leiden: Institute of Cultural and Social Studies, ICA Publication no. 60, 1983. iii + 132 pp.-W. van Wetering, Charles J. Wooding, Evolving culture: a cross-cultural study of Suriname, West Africa and the Caribbean. Washington: University Press of America 1981. 343 pp.-Humphrey E. Lamur, Sergio Diaz-Briquets, The health revolution in Cuba. Austin: University of Texas Press, 1983. xvii + 227 pp.-Forrest D. Colburn, Ramesh F. Ramsaran, The monetary and financial system of the Bahamas: growth, structure and operation. Mona, Jamaica: Institute of Social and Economic Research, University of the West Indies, 1984. xiii + 409 pp.-Wim Statius Muller, A.M.G. Rutten, Leven en werken van de dichter-musicus J.S. Corsen. Assen, The Netherlands: Van Gorcum, 1983. xiv + 340 pp.-Louis Allaire, Ricardo E. Alegria, Ball courts and ceremonial plazas in the West Indies. New Haven: Department of Anthropology of Yale University, Yale University Publications in Anthropology No. 79, 1983. lx + 185 pp.-Kenneth Ramchand, Sandra Paquet, The Novels of George Lamming. London: Heinemann, 1982. 132 pp.

Background:Treat-to-target strategy has been proposed in SLE. Achieving remission/LDAS should prevent damage, reduce mortality and improve HRQoL.Objectives:To determine the protective value of remission or LDA states on HRQoL in SLE using a SLR.Methods:Two independent reviewers identified studies in Medline and Cochrane library and extracted data on remission, LDA and HRQoL. Remission and LDA definitions included disease activity (SLEDAI and its variants, SLAM and PGA), serological activity, new organ/system, prednisone (PDN) dose (mg/day), immunosuppressives (IS) drugs, antimalarial (AM) use and remission duration. The quality of the studies was assessed with the Newcastle-Otawa Scale (NOS).Results:Three manuscripts (1059 patients) for remission and 4 (2385 patients) for LDA were included (America, Europe &amp; Asia Pacific). All the studies reached seven out of nine NOS points. Remission rates ranged 25-39%; and LDA: 42-62%. Even less stringent remission or LDA definitions predicted/were associated with a better HRQoL. Physical rather than mental domains were more associated with remission or LDA.Table 1.Association between remission and HRQoLAuthorsCountry/RegionPatientsRemissionRemission (%)Domains positively associated or predicted by remissionMok et al*China769SLEDAI=0Serologic= AllowedPGA&lt;0.5PDN ≤ 5IS=YesAM=YesDuration≥5years25.1Remission&gt;5 years vs not on remissionSF-36:Role physical, bodily pain, general health, vitality, social functioning, role emotional, PCS and MCSLupusPRO:Symptoms, medications, procreation, physical health, pain, emotional, image, HRQoL totalTsang-A-Sjoe et al#Netherlands154SLEDAI=0Serologic= allowedPGA ≤2/10PDN ≤ 5IS=YesAM=YesDuration=NR39.0 at baselineRemission on- or off-therapy predicted a better SF-36 PCS but not MCSMargiotta et al*Italy136SLEDAI=0Serologic= allowedPGA= NRPDN ≤ 5IS=YesAM=YesDuration&gt;5 years39.0Remission &gt;5years vs unremitted or remission&lt;5 yearsSF-36:Physical health, role physical, bodily pain, general health, social functioningPCS: Physical component summary. MCS: Mental component summary. *Cross-sectional #LongitudinalTable 2.Association between LDA and HRQoLAuthorsCountry/RegionPatientsLDALDA (%)Domains positively associated or predicted by LDASGolder et al*Asia Pacific1422SLEDAI≤ 4PGA≤ 1PDN ≤ 7.5IS=YesAM=YesNew manifestations: NoDuration=NR42.0SF-36:Role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health, PCS and MCSUgarte-Gil et al#USA483SLAM≤ 3PGA=NRPDN ≤ 7.5IS=NoAM=YesNew manifestations: NRDuration=NRNRSF-36:Physical function, role physical, bodily pain, general health, vitality, social functioning, role emotional, mental health, PCS and MCSUgarte-Gil et al#Peru243SLEDAI≤ 4PGA=NRPDN ≤ 7.5IS=YesAM=YesNew manifestations: NRDuration=NR48.6 at baselineLupusQoLPhysical health, pain, planning, burden to others, emotional health, fatiguePoomsalood et al*Thailand237SLEDAI≤ 2Serologic= allowedPGA=NRPDN ≤ 7.5IS=YesAM=YesNew manifestations: NRDuration=NR61.6SLEQoLUnivariable:physical, activities, symptom, treatment, mood, self-image and total.Multivariable: Better global QoLPCS: Physical component summary. MCS: Mental component summary. *Cross-sectional #LongitudinalConclusion:In SLE patients, achieving remission or LDA, is associated with a better HRQoL.Disclosure of Interests:Manuel F. Ugarte-Gil Grant/research support from: Jannsen, Pfizer, Claudia Mendoza Pinto: None declared, Cristina Reategui Sokolova: None declared, Guillermo Pons-Estel Grant/research support from: JANSSEN and GSK, Consultant of: JANNSEN, GSK and SANOFI, Speakers bureau: PFIZER, JANNSEN and GSK, Ronald van Vollenhoven Grant/research support from: AbbVie, Arthrogen, Bristol-Myers Squibb, GlaxoSmithKline, Lilly, Pfizer, and UCB, Consultant of: AbbVie, AstraZeneca, Biotest, Bristol-Myers Squibb, Celgene, GSK, Janssen, Lilly, Medac, Merck, Novartis, Pfizer, Roche, and UCB, George Bertsias Grant/research support from: GSK, Consultant of: Novartis, Graciela S Alarcon: None declared, Bernardo Pons-Estel Grant/research support from: GSK, Janssen, Consultant of: GSK, Janssen, Speakers bureau: GSK, Janssen

Toilet training is one way to train children's independence in clean and healthy living behaviour as a provision for children's life skills in entering the next education level. The research problem is that the child's independence has not yet developed, which is marked by the child not yet being independent in defecating and urinating. The research aims to train children's independence in defecation and urination through demonstration methods and find out whether toilet training activities through demonstration methods can affect children's independence. The research subjects were 50 children. A research approach is quantitative with experimental methods. The data collection technique used pre and post-tests for children's independence with the child's toilet training ability as a measuring tool. The results of data collection were processed by statistical testing the Non-Parametric Wilcoxon Signed Ranks Test. The study found a contrast in toilet training ability before and after being treated with a demonstration technique which has a value of 0.05 with a P value &lt;0.005. The research results conclude that the toilet training demonstration method was effective in increasing children's independence in Kindergarten, Donggala Regency, Central Sulawesi.&#x0D; Keywords: early childhood, toilet training, independence skills&#x0D; References:&#x0D; Baird, D. C., Bybel, M., &amp; Kowalski, A. W. (2019). Toilet Training: Common Questions and Answers. 100(8).&#x0D; Campbell, D. T., &amp; Stanley, J. C. (2015). Experimental and Quasi-Experimental Designs for Research. Ravenio Books. https://books.google.co.id/books?id=KCTrCgAAQBAJ&#x0D; Cerino, A. (2021). The importance of recognising and promoting independence in young children: The role of the environment and the Danish Forest school approach. Education 3-13, 1–10. https://doi.org/10.1080/03004279.2021.2000468&#x0D; Choby, B. A., &amp; George, S. (2005). Toilet training. American Family Physician, 78 9, 1059–1064.&#x0D; DeLuca, C., Pyle, A., Braund, H., &amp; Faith, L. (2020). Leveraging assessment to promote kindergarten learners’ independence and self-regulation within play-based classrooms. Assessment in Education: Principles, Policy &amp; Practice, 27(4), 394–415. https://doi.org/10.1080/0969594X.2020.1719033&#x0D; Devries, M. W., &amp; DeVries, M. R. (1977). Cultural relativity of toilet training readiness: A perspective from East Africa. Pediatrics, 60 2, 170–177.&#x0D; Febrianti, A. (2021). Demographic Characteristics of Mothers with Toilet Training Ability in Children. Jurnal Kesehatan Abdurrahman, 10(1), 48–57. https://doi.org/10.55045/jkab.v10i1.122&#x0D; Hildebrand, V. (1988). Young Children’s Self‐care and Independence Tasks: Applying Self‐Efficacy Theory. Early Child Development and Care, 30(1–4), 199–201. https://doi.org/10.1080/0300443880300116&#x0D; Hooman, N., Safaii, A., Valavi, E., &amp; Amini-Alavijeh, Z. (2013). Toilet Training in Iranian Children: A Cross-Sectional Study. Iranian Journal of Pediatrics, 23, 154–158.&#x0D; Khoiruzzadi, M., &amp; Fajriyah, N. (2019). Learning Toilet Training in Training Children’s Independence. JECED: Journal of Early Childhood Education and Development, 1(2), 142–154. https://doi.org/10.15642/jeced.v1i2.481&#x0D; Kiddoo, D. A. (2012). Toilet training children: When to start and how to train. Canadian Medical Association Journal, 184(5), 511. https://doi.org/10.1503/cmaj.110830&#x0D; Kiftiyah, K., Wardani, R. A., &amp; Rosyidah, N. N. (2018). The Effect of Demonstration Methods About Toilet Training on Improving Toilet Train-ing Learning In Children Aged 3 Years In Paud I Sooko Village, Sooko District, Mojokerto Regency. Nurse and Health: Jurnal Keperawatan, 7(1), 71–79. https://doi.org/10.36720/nhjk.v7i1.35&#x0D; Klassen, T. P., Kiddoo, D. A., Lang, M. E., Friesen, C., Russell, K., Spooner, C. H., &amp; Vandermeer, B. (2006). The effectiveness of different methods of toilet training for bowel and bladder control. Evidence Report/Technology Assessment, 147, 1–57.&#x0D; Meilisa, A. N., Hasanah, O., &amp; Amir, Y. (2022). Relationship between Toilet Training Initiation Age and Factors Affecting Toilet Training to Toilet Training Achievements. Indonesian Health Scientific Journal, 7(1).&#x0D; Mota, D. M., &amp; Barros, A. J. D. (2008). Toilet training: Methods, parental expectations and associated dysfunctions. Jornal de Pediatria, 84(1), 9–17. https://doi.org/10.2223/JPED.1752&#x0D; Ngatemi, Purnama, T., &amp; Kasihani, N. N. (2021). Independence of Brushing Teeth to Free-Plaque Score in Preschool Children: A Cross Sectional Study. Indian Journal of Forensic Medicine &amp; Toxicology. https://doi.org/10.37506/ijfmt.v15i3.15875&#x0D; Polaha, J., Warzak, W. J., &amp; Dittmer-Mcmahon, K. (2002). Toilet training in primary care: Current practice and recommendations from behavioral pediatrics. J Dev Behav Pediatr, 23(6), 424–429. PubMed. https://doi.org/10.1097/00004703-200212000-00005&#x0D; Rahayu, S. F. (2022). Relationship Pattern of Working Parents To The Independence Of Toilet Training Pre School Children (Literature Study). Healthy-Mu Journal, 4(2), 82–87. https://doi.org/10.35747/hmj.v4i2.27&#x0D; Schum, T. R., Kolb, T. M., McAuliffe, T. L., Simms, M. D., Underhill, R. L., &amp; Lewis, M. (2002). Sequential acquisition of toilet-training skills: A descriptive study of gender and age differences in normal children. Pediatrics, 109 3, E48.&#x0D; Smeets, P. M., Lancioni, G. E., Ball, T. S., &amp; Oltva, D. S. (1985). Shaping Self-Initiated Toileting in Infants. Journal of Applied Behavior Analysis, 18(4), 303–308. https://doi.org/10.1901/jaba.1985.18-303&#x0D; Sun, M., &amp; Rugolotto, S. (2004). Assisted Infant Toilet Training in a Western Family Setting. Journal of Developmental &amp; Behavioral Pediatrics, 25(2). https://journals.lww.com/jrnldbp/Fulltext/2004/04000/Assisted_Infant_Toilet_Training_in_a_Western.4.aspx&#x0D; Tarhan, H., Çakmak, Ö., Akarken, I., Ekin, R. G., Ün, S., Uzelli, D., Helvaci, M., Aksu, N., Yavaşcan, Ö., Özsan, F. M., Cun, S., Koç, F., Özkarakaş, Ö., Ilbey, Y. O., &amp; Zorlu, F. (2015). Toilet training age and influencing factors: A multicenter study. The Turkish Journal of Pediatrics, 57 2, 172–176.&#x0D; Vermandel, A., Van Kampen, M., Van Gorp, C., &amp; Wyndaele, J.-J. (2008). How to toilet train healthy children? A review of the literature. Neurourology and Urodynamics, 27(3), 162–166. https://doi.org/10.1002/nau.20490&#x0D; Yanti, A. F. (2021). The Role of Parents in Discipling Toilet Training for Early Children (Case Study of Chil-dren Aged 2-4 Years in Bakal Dalam Village, Talo Kecil District, Seluma Regency). Al Fitrah: Journal of Early Childhood Islamic Education.&#x0D;

Background:Defining remission for SLE as a suitable target for a treat to target (T2T) approach has been a major challenge in the past years. A few years back, four definitions of remission were presented by the international DORIS task force.[1] Parameters included in the definition are clinical activity (cSLEDAI), steroid dose, immunosuppressive therapy, serology and physician global assessment (PGA). In particular the PGA, its threshold and general utility have been and still are discussed controversially.Objectives:It was our aim to evaluate the added value of PGA in remission assessment.Methods:In this monocentric cross-sectional study, patients with SLE according to the 1997 American College of Rheumatology (ACR) criteria were enrolled and assessed between September 2016 and December 2017. Two different definitions of remission were applied. The internationally accepted DORIS remission and a modified DORIS remission excluding PGA. Factors influencing PGA were assessed in the entire cohort. Regression analyses were used to assess differences between patients in DORIS and modified DORIS remission.Results:A total of 233 patients were included (87.6% female). 98 patients (41.9%) fulfilled any of the four DORIS remission definitions, while 154 patients (66.1%) were in any modified remission in which PGA was excluded. In general, PGA rating was associated with disease activity (clinical SLEDAI; p=&lt;0.0001), depression (Center for Epidemiological Studies Depression Scale; p=0.049), pain reported by the patient (numeric rating scale; p=&lt;0.0001) and hypocomplementemia (p=&lt;0.0001). Damage (SLICC damage index, SDI) did not influence PGA (p=0.98). Both, DORIS and modified DORIS remission were associated with lower damage (p=0.026; p=0.003), lower pain on NRS (p=0.001; p=0.013), normal complement (p=0.0005; p=0.005) and better illness perception (p=0.006; p=0.023). Patients in modified DORIS remission had a tendency for more immunosuppressive therapy (p=0.046).Conclusion:Exclusion of PGA in remission assessment led to an increased number of patients in remission. Clinical parameters and factors associated with DORIS remission vs. modified DORIS remission were similar, hence the added value of PGA in our cohort regarding remission assessment is questionable. The use and especially the correct threshold of PGA for remission still has to be discussed.References:[1]van Vollenhoven, Ronald; Voskuyl, Alexandre; Bertsias, George; Aranow, Cynthia; Aringer, Martin; Arnaud, Laurent et al. (2017): A framework for remission in SLE: consensus findings from a large international task force on definitions of remission in SLE (DORIS). In:Annals of the rheumatic diseases76 (3), S. 554–561. DOI: 10.1136/annrheumdis-2016-209519.Disclosure of Interests:Johanna Mucke: None declared, Christina Duesing: None declared, Matthias Schneider Grant/research support from: GSK, UCB, Abbvie, Consultant of: Abbvie, Alexion, Astra Zeneca, BMS, Boehringer Ingelheim, Gilead, Lilly, Sanofi, UCB, Speakers bureau: Abbvie, Astra Zeneca, BMS, Chugai, GSK, Lilly, Pfizer, Sanofi, Gamal Chehab Grant/research support from: Grant/research support from: GlaxoSmithKline and UCB Pharma for performing the LuLa-study.

Innovations are the phenomenon of globalizing, dynamic and highly competitive markets of goods, services and ideas. Open innovations cross the borders of companies, of countries and of continents and because of it are regarded as cross-cultural process. Georgia&rsquo;s wide-sсale integrationinto global innovation networks supposes the development of cross-cultural competencies for Georgia society. The knowledge and understanding at least, and possibly, the adoption of cultural values of the nations &ndash; global innovation leaders - are important

Although, genetically modified (GM) crops have to be a broadly debated topic in different countries, there has been much less attention devoted to farmer attitudes towards GM crops. This paper attempts to research farmers&rsquo; insights on GM crops in Georgia through February-March 2014. An in-depth survey of 611 farmers revealed that respondents lack sufficient knowledge about genetic engineering. They tend to have a negative attitude towards GM crops and are strongly against of import and adoption of GM seeds. An empirical examination based on analysis of variance and Pearson&rsquo;s correlation coefficient verified that both education and age were significant determinants of awareness of farmers about genetically engineered crops, while income used to have no significant influence on the farmers&rsquo; decision to adopt GM crops. In addition, relationship between awareness about genetic engineering and farmers&rsquo; decision to adopt GM crops has to be insignificant, as well.

Turmel, M. S., Entz, M. H., Tenuta, H., May, W. E. and LaFond, G. P. 2011. The influence of a long-term black medic ( Medicago lupulina cv. George) cover crop on arbuscular mycorrhizal fungal colonization and nutrient uptake in flax ( Linum usitatissimum ) under zero-tillage management. Can. J. Plant Sci. 91: 1071–1076. Leguminous cover crops are becoming a popular way to increase the sustainability of agricultural systems. Previously, cover crops have been found to increase colonization by arbuscular mycorrhizal fungi (AMF) and phosphorus and micronutrient uptake. Long-term field studies were conducted to test the hypothesis that self-regenerating black medic (Medicago lupulina cv. George) cover crops increase AMF colonization and early nutrient uptake in flax (Linum usitatissimum). Field experiments were established in 2000 (Manitoba) and 2002 (Saskatchewan) using a flax–wheat (Triticum aestivum)–oat (Avena sativa) rotation. In a second experiment, intact soil cores were harvested from the plots in spring and tested for soil disturbance and cover crop effects under controlled environment conditions (CEC). Both seedling flax crops sampled from the field in 2005 and 2006 and flax growth in CEC showed high levels of AMF root colonization, but no significant influence of the cover crop on AMF colonization by arbuscules or hyphal structures was detected. The AMF enhancing practices used in the experiments (i.e., zero-tillage and inclusion of mycorrhizal crops) may have contributed to the lack of cover crop effect on AMF colonization. The cover crop had no effect on macro- or micronutrient uptake by flax except during drought conditions (Winnipeg 2006), where flax biomass was reduced by 38% and the total uptake of N, P, Zn and Cu was decreased by 34, 30, 31 and 35%, respectively, in the medic treatment.

Abstract Chemotherapy resistance represents a major problem in ovarian cancer prognosis and reliable indicators of chemotherapy sensitivity remain an unmet need. Here, we examined metabolic profiles of pre- and post-neoadjuvant chemotherapy (NACT) tumor samples from patients with high-grade serous ovarian cancer (HGSC). We performed spatially resolved, desorption electrospray ionization-mass spectrometry (DESI-MS) on sections from clinically annotated HGSC samples collected according to a laparoscopic triage algorithm from patients pre- and post-NACT. Patients were considered to be either excellent (ER) if they presented complete response or only microscopic disease left at interval surgery, or poor responders (PR) if they presented stable or progressive disease after NACT. Tumor tissues from 50 patients (29 ER and 21 PR, 13 ER matched pre and post NACT, 13 PR matched pre and post-NACT) were eligible for the analyses Data relative to the detected metabolites, were collected from epithelium and stroma separately. We first identified differentially upregulated metabolites in ER and PR groups and performed pathway analysis. The over-represented pathways in the chemo-naïve PR tissues included the nucleotide metabolism pathway in epithelial areas, and degradation of cysteine and homocysteine, metabolism of amino acids and derivatives, as well as sulfur amino acids metabolism in the stromal areas (p values FDR adjusted 0.045). In general, both the epithelium and stroma of PR tissues of chemo-naïve tumors, contained a higher number and a higher variety of lipid species compared with ER tissues. In post-NACT tumor epithelial areas, there was global downregulation of metabolites across all patient samples, compared to the pre-chemo specimens; this was more evident in ER patients. In post-NACT tumors from PR patients, glutathione synthesis and recycling pathway, and sulfite oxidation to sulfate pathway and many glycerolipids species were upregulated in the epithelium, while phosphatidic acids were upregulated in the stroma. Lastly, we evaluated the predictive power of the metabolic data extracted by the epithelial areas of chemo-naïve tissues, in classifying patients as ER or PR. We used 10-fold cross-validation to create a ridge regression model for the classification of ER and PR samples from pre-NACT tumor tissues. This model, based on 78 differentially expressed metabolites (small molecules and lipids), correctly classified patients as ER or PR with an accuracy of 76.2% (sensitivity 84.6% and specificity 62.5%). Our findings indicate altered metabolic pathways in ovarian cancer tissues based on response to NACT. The identification of differentially activated pathways, such as sulfate metabolism and glutathione metabolism in tumors with poor response, suggest novel actionable targets to overcome chemotherapy resistance in patients with HGSC. Citation Format: Sara Corvigno, Meredith Spraldin, Michael Keating, Sunil Badal, Igor Pereira, Elaine Stur, Nicholas Bateman, Waleed Barakat, Thomas Conrads, Sanghoon Lee, George Maxwell, Susan K. Lutgendorf, Premal Thaker, Jinsong Liu, Nicole Fleming, Katheleen Darcy, Livia S. Eberlin, Anil K. Sood. Metabolic profiling of pre and post treatment ovarian cancer tissues using in situ mass spectrometry imaging [abstract]. In: Proceedings of the American Association for Cancer Research Annual Meeting 2022; 2022 Apr 8-13. Philadelphia (PA): AACR; Cancer Res 2022;82(12_Suppl):Abstract nr 2331.

Khanna A, Goyal RS, Bhawsar R. Menstrual practices and reproductive problems Study of adolescent girls in Rajasthan. J Health Manag. 2005;7(1):91–107. Ersoy B, et al. Effects of different socioeconomic conditions on Menarche in Female Turkish Students. Early Hum Dev. 2004;76(2):115–25. Dongre AR, Deshmukh PR, Garg BS. The effect of community-based health education interventions on menstrual hygiene management among rural Indian adolescent girls. World Health Popul. 2007;9(3):48–54. Tang CS, Yeung DY, Lee AM. Psychosocial correlates of emotional Responses to menarche among Chinese adolescent girls. J Adolescent Health. 2003;33(3):193–201. Adhikari P, et al. Knowledge and practice regarding menstrual hygiene in rural adolescent girls in Nepal. Kathmandu Univ Med J (KUMJ). 2007;5(3):382–6 Ali TS, Rizvi SN. Menstrual knowledge and practices of female adolescents in urban Karachi, Pakistan. J Adolescent. 2010;33(4):531–41. Bobhate P, Shrivastava S et al.. 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The accepted rule for women contributing to nineteenth-century science before 1851 was that they could play only secondary roles in its production and authorship—as translators, illustrators, popularizers—and these by virtue of kinship or marriage to eminent scientists in the field or the laboratory. Sarah Bowdich (Lee) (1791–1856) presents an important amendment to this rule. As an explorer of West Africa on an equal scientific footing with her husband, and then a writer of science independently after his early death, she had other key roles as Georges Cuvier's cross-Channel scientific collaborator and as his first biographer. This article investigates and reframes Sarah's many individual achievements in science and its writing, to examine the larger questions of her case. How were her publications and ‘uneasy career’ in science possible? Can research on women in science today find inspiration in her example?

Összefoglaló. Bevezetés: Krónikus obstruktív tüdőbetegségben (COPD) az obesitas mellett a csökkent fizikai aktivitás nagymértékben fokozza a metabolikus szindróma kialakulásának valószínűségét. Célkitűzés: Kutatásunk célja volt felmérni a metabolikus szindróma prevalenciáját COPD-ben, valamint azt, hogy milyen mértékben függ össze az életkorral, a nemmel, a társbetegségekkel, a tüdőfunkció károsodásának mértékével, a tápláltsági állapottal, a fizikai terhelhetőséggel és az életminőséggel. Módszer: Keresztmetszeti vizsgálatot végeztünk az Országos Korányi Pulmonológiai Intézet Légzésrehabilitációs Osztályán fekvő betegek körében 2019. július 1. és december 31. között. A véletlenszerűen kiválasztott 300, 40 év feletti betegnek ismertük az antropometriai, légzésfunkciós vizsgálati eredményét és laboratóriumi paramétereit. Adatokat gyűjtöttünk a dohányzási szokásokról, az előző évi exacerbatiók számáról és a kortikoszteroidok használatáról is. Az életminőség mérésére a betegségspecifikus Szent György-féle Légzési Kérdőív magyar nyelvre validált változatát használtuk. A metabolikus szindrómát a Nemzetközi Diabetes Szövetség kritériumai alapján határoztuk meg. Eredmények: A metabolikus szindróma a betegek 72%-ánál fordult elő, férfi: 65,9% nő: 77,2% (p = 0,031). A metabolikus szindrómás betegek esetében rövidebb 6 perces sétatávolságot mértünk ([m] 250 [150–330] vs. 295 [162–360]; p = 0,384), és szignifikánsan több volt az előző évi exacerbatiók száma (3 [0–6] vs. 1 [1–2]; p&lt;0,001) a nem metabolikus szindrómás betegekhez képest. A BMI-re történő stratifikáció után a metabolikus szindróma jelenléte nagyobb volt BMI≥25 kg/m2 esetén. A hasi elhízás, a magas vérnyomás, a hyperlipidaemia és a hyperglykaemia szignifikánsan gyakoribb volt BMI≥25 kg/m2 esetén (p&lt;0,001). Következtetés: Eredményeink azt sugallják, hogy a metabolikus szindrómás betegekben megnő az együttes morbiditási index, különösen azok körében, akik túlsúlyosak vagy elhízottak. Ezért a COPD-s betegekben nagyon fontos időben felismerni és megfelelően kezelni a metabolikus szindrómát. Orv Hetil. 2021; 162(5): 185–191. Summary. Introduction: Both obesity and the lack of physical activity among chronic obstructive pulmonary disease (COPD) patients increase the risk of developing metabolic syndrome. Objective: The goal of our study was to assess the prevalence of metabolic syndrome among COPD patients and to examine its correlation with age, gender, comorbidities, lung function values, nutritional status, exercise capacity, and quality of life. Method: A cross-sectional study was performed at the Department of Pulmonary Rehabilitation of the Hungarian National Korányi Institute for Pulmonology between July 1st and December 31st, 2019. A total of 300 patients aged over 40 were selected at random. Anthropometric data were collected along with lung function values, laboratory parameters, smoking status, the number of exacerbations in the previous year, and the use of corticosteroids. Quality of life was measured by the validated Hungarian, COPD-specific Saint George Respiratory Questionnaire. Metabolic syndrome was defined according to the International Diabetes Federation criteria. Results: Metabolic syndrome affected 72% of COPD patients (male: 65.9%, female 77.2%; p = 0.031). In patients with metabolic syndrome, shorter 6-minute walking distance was measured ([m] 250 [150–330] vs. 295 [162–360]; p = 0.384) and the number of exacerbations in the previous year was significantly higher (3 [0–6] vs. 1 [1–2]; p&lt;0.001) compared to patients with no metabolic syndrome. After stratification for BMI, metabolic syndrome was more frequent in the case of BMI≥25 kg/m2. Central adiposity, hypertension, hyperlipidemia, and hyperglycemia were also significantly more frequent among patients with BMI≥25 kg/m2 (p&lt;0.001). Conclusion: Our results suggest that the co-morbidity index increases in patients with metabolic syndrome, especially in overweight or obese patients. Therefore, early detection and appropriate treatment of metabolic syndrome in patients with COPD is very important. Orv Hetil. 2021; 162(5): 185–191.

Abstract Background: Black and Latina/Hispanic women are more likely to be diagnosed with and die from cervical cancer than White women in the US. Having adequate health insurance, a social and structural determinant of health, may be associated with an earlier stage cervical cancer diagnosis and improved prognosis for racial/ethnic minorities. Objective: To determine whether insurance status among racial/ethnic groups is associated with earlier diagnosis of cervical cancer among a large and diverse population of US women with cervical cancer. Methods: A retrospective, cross-sectional population-based study utilizing data from the Surveillance, Epidemiology, and End Results Census Tract-Level Socioeconomic Status and Rurality Database on 24,945 women aged 21-64 years who were diagnosed with a histologically confirmed invasive cervical cancer between January 1, 2007, to December 31, 2016. The primary outcome was the risk of having a more advanced cervical cancer diagnosis (regional or distant versus localized). Causal mediation analyses were performed using a series of multivariable logistic regression models to determine the association of race/ethnicity with cervical cancer stage and the potential mediator, health insurance status (private insurance versus Medicaid coverage or no insurance). Adjusted odds ratios (OR) and 95% confidence intervals were calculated, and estimates of direct and indirect effects of race/ethnicity and cervical cancer stage were used to calculate the proportion mediated (PM) by health insurance status. Results: 24,945 women (median [IQR] age, 45 [37-54] years) were included in the study. 52% of women were identified as Non-Hispanic (NH) White, 13% as NH Black, and 24% as Hispanic/Latina. Overall, 14,271 women had private insurance, 9,765 women were uninsured or received Medicaid, and 909 women had no documented insurance status. A larger proportion of women who were uninsured or received Medicaid were diagnosed with more advanced stage cancer (regional/distant) compared to women with private health insurance (53.5% versus 42.0%). In models adjusted for age, year of diagnosis and histology type: NH Black (OR 1.38, 95% CI 1.27-1.50), and Hispanic/Latina (OR 1.13, 95% CI 1.06-1.21) women had higher odds of being diagnosed with regional/distant cancer compared to NH White women. After adjustment for insurance status and accounting for co-mediation by area-level socioeconomic status, the association with regional/distant cervical cancer was attenuated toward the null (Black: OR 1.18, 95% CI 1.08-1.29; Hispanic/Latina: OR 0.93, 95% CI 0.87-1.00). Our mediation analysis found that over half (PM 51% to 56%) of the inequities in cervical cancer diagnosis were mediated by health insurance across all racial/ethnic groups. Conclusion: In this population-based sample of US women, insurance status was major mediator of over half the racial/ethnic inequities in late-stage cervical cancer diagnoses. Focused policies making robust health coverage accessible may mitigate the known inequities in cervical cancer diagnosis and outcomes. Citation Format: Hunter K. Holt, Caryn Peterson, Shannon MacLaughlan, George F. Sawaya, Gregory S. Calip. Mediation of racial/ethnic inequities in the diagnosis of early-stage cervical cancer by insurance status [abstract]. In: Proceedings of the 15th AACR Conference on the Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved; 2022 Sep 16-19; Philadelphia, PA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2022;31(1 Suppl):Abstract nr A091.

Abstract Introduction: Invasive lobular carcinoma (ILC) is the most frequent special histologic subtype of breast cancer (BC). ILC is identifiable by pathologic assessment given its distinctive discohesive growth pattern, largely caused by CDH1 inactivation. Compared to common forms of BC, ILCs display lower responses to chemotherapy and selective estrogen receptor modulators. The low interobserver agreement for the diagnosis of ILC, however, renders the inclusion of histologic subtyping in therapeutic decision-making challenging. Artificial intelligence (AI)-based algorithms hold promise for improving pathologic diagnosis; their performance, however, depends on the ground truth labeling used. Here, we seek to develop an AI-based methodology for detection of ILC using ‘CDH1 biallelic mutations’ (i.e., mutation + loss-of-heterozygosity of the wild-type allele or two pathogenic somatic mutations) as ground truth, reasoning that in BC, &amp;gt;95% of CDH1 bi-allelic inactivation is found in ILCs.Materials and methods: We developed a convolutional neural network system to detect CDH1 biallelic genetic inactivation (AI-CDH1) using whole slide images (WSI) of 1,100 primary BCs with available targeted sequencing data. The model was trained using a 10-fold cross-validation method to detect biallelic mutations. The mean number of positive and negative samples in the training set was 85.2 (SD=2.57) and 562.8 (SD=10.51) per fold, respectively. The evaluation set consisted of a mean of 14.2 (SD=2.04) positive and 93.8 (SD=9.13) negative samples. We evaluated the performance of the AI-CDH1 classifier to predict the lobular phenotype and CDH1 status using original and revised labels, following a histopathologic re-review of the histologic type and CDH1 status curation. The latter was conducted by incorporating information on biallelic CDH1 inactivation beyond CDH1 mutations (homozygous deletions, deleterious structural rearrangements, and loss-of-heterozygosity and gene promoter methylation).Results: The AI-CDH1 classifier predicted biallelic CDH1 mutations with an area under the curve (AUC)=0.944 (95 CI: 0.925-0.963), sensitivity=91.6% and specificity=85.9%, PPV=49.8%, NPV=98.5% and accuracy=86.7%, and the original ‘lobular phenotype’ with an AUC=0.941 (95 CI: 0.922-0.960), sensitivity=89%, specificity=86.7%, PPV=55.6%, NPV=97.7% and accuracy=87.1%. Review of the CDH1 gene status revealed that 7/957 BCs lacking CDH1 biallelic mutations harbored biallelic CDH1 inactivation by promoter methylation, homozygous deletions or structural rearrangements. The AI-CDH1 classifier detected all seven reclassified BCs and predicted the revised CDH1 biallelic inactivation with an AUC=0.948 (95 CI: 0.930-0.966), sensitivity=92%, specificity=86.5%, PPV=52.3%, NPV=98.5% and accuracy=87.2%. Upon histologic re-review, which resulted in reclassification of 36/927 non-lobular BCs as ‘lobular’ and 5/173 ‘lobular’ BCs as ‘non-lobular’, the AI-CDH1 classifier detected the ‘lobular phenotype’ with an AUC=0.953 (95 CI: 0.935-0.971), sensitivity=90.7%, specificity=89.7%, PPV=66.8%, NPV=97.7% and accuracy=89.9%. Using the revised histologic re-classification and CDH1 biallelic inactivation status labels, the AI-CDH1 classifier predicted the lobular phenotype irrespective of CDH1 status (P&amp;gt;0.05).Conclusions: By training a machine learning system to detect ‘CDH1 biallelic mutations’, as ground truth rather than histologic diagnosis of lobular carcinoma, which might be confounded by human subjectivity, we developed an AI-based system that can detect ILCs accurately, providing a new paradigm for the development of AI-based cancer classification systems. Citation Format: Jorge S Reis-Filho, Fresia Pareja, Fatemeh Derakhshan, David N Brown, Jillian Sue, Pier Selenica, Yi Kan Wang, Arnaud Da Cruz Paula, Monami Banerjee, Zahra Ebrahimzadeh, Manuel Isava, Matthew Lee, Ran Godrich, Adam Casson, Ruben Padron, George Shaikovski, Alexander van Eck, Antonio Marra, Higinio Dopeso, Hannah Y Wen, Edi Brogi, Matthew G Hanna, Chris Kanan, Jeremy D Kunz, Felipe C Geyer, Carla Leibowitz, David Klimstra, Leo Grady, Thomas J Fuchs. An artificial intelligence-based predictor of CDH1 biallelic mutations and invasive lobular carcinoma [abstract]. In: Proceedings of the 2021 San Antonio Breast Cancer Symposium; 2021 Dec 7-10; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2022;82(4 Suppl):Abstract nr PD11-01.

The work analyses the historical roof of Derneburg Castle, in the municipality of Holle, Hildesheim’s district, Lower Saxony, Germany. The roof is assembled according to &lt;i&gt;Laves Balken&lt;/i&gt;’s system (Laves beam’s system), developed by the architect Georg Ludwig Friedrich Laves (1788&amp;amp;ndash;1864). The system has the peculiarity to consist of beams that are split along the half of the cross section, and maintained diverged by wooden wedges, distributed along the length of the beam. The system increases the height of the beam, and elevates the bending capacity of it (Weber, 1964). The work has been developed in the frame of an interdisciplinary project in the fields of architecture, engineering and photogrammetry. Main aim of the project is the developing of a structural model to understand the load-carrying capacity of &lt;i&gt;Laves Balken&lt;/i&gt;’s system from the laser-scanning model. For this reason, extensive surveys and photo documentation were collected on three areas of the roof construction, characterized by three peculiar usage of &lt;i&gt;Laves Balken&lt;/i&gt;’s system. The work presents the survey of the pagoda-roof that covers the tower of the castle, and problems that can be encountered during the survey of very complex timber constructions.

Increasing efforts are needed to meet the growing demand for green energy storage. As lithium-ion batteries reach their theoretical limits, new post-lithium technologies are required.1 Within this frame, Li-S batteries are particularly promising since they are based on conversion reactions that involve more than one lithium ion, leading to high theoretical capacities (e.g., FeS2 lithiation involves 4 Li+, theoretical capacity 894 mAh·g-1).2 In addition, the active materials employed are naturally abundant, inexpensive, and non-toxic, and all-solid-state batteries can provide improved safety. Argyrodites are sulfide solid electrolytes with promising ionic conductivity (e.g., Li5.5PS4.5Cl1.5 6-11 mS·cm−1). They have a narrow electrochemical stability window outside of which sulfur and/or phosphor redox occur. It is known that small particles of conversion-type active material enhance electrochemical performances.3,4 Tuning the cathode composite fabrication can be a cheap and easy mechanical method to tune its structure.5 To investigate the impact of cathode processing, FeS2-based Li-S all-solid-state batteries (FeS2/LPSCl1.5/carbon black | LPSCl1.5 | In/InLi) are fabricated. Different processing methods (i.e., hand grinding, oscillating ball mill, and conventional ball mill) are compared using electrochemical and analytical characterizations (e.g., XRD, SEM-EDX, and XPS). We reveal that the cathode processing has a significant impact on the electrochemical performances of conversion-based cathodes. The achieved specific capacity of the composite mixed via conventional ball mill is more than twice that of the one mixed by oscillating ball mill. Ex-situ SEM images of cathode cross-sections show that the conventional ball mill produces more homogeneous and finely distributed composites compared to the oscillating ball mill (Figure 1). This demonstrates the significant effect of the cathode processing and the importance of composite microstructure and design. Moreover, the experimental capacity achieved using the conventional ball mill is larger than the theoretical one of FeS2. We further investigate the origin of this additional capacity electrochemically. Figure 1: SEM images of the pristine cathode composites made of FeS2, LPSCl1.5, and carbon black. The composites were mixed via a) hand grinding b) oscillating ball mill c) conventional ball mill. References 1 Janek, Jürgen; Zeier, Wolfgang G. Nat Energy. 8, 2023. DOI: 10.1038/s41560-023-01208-9. 2 Whang, Grace; Zeier, Wolfgang G. ACS Energy Lett. 8 (12), 2023. DOI: 10.1021/acsenergylett.3c02246. 3 Dewald, Georg F.; Ohno, Saneyuki; Kraft, Marvin A.; Koerver, Raimund; Till, Paul; Vargas-Barbosa, Nella M.; Janek, Jürgen; Zeier, Wolfgang G. Chem. Mater. 31 (20), 2019. DOI: 10.1021/acs.chemmater.9b01550. 4 Wang, Shuo; Tang, Mingxue; Zhang, Qinghua; Li, Baohua; Ohno, Saneyuki; Walther, Felix; Pan, Ruijun; Xu, Xiaofu; Xin, Chengzhou; Zhang, Wenbo; Li, Liangliang; Shen, Yang; Richter, Felix H.; Janek, Jürgen; Nan, Ce-Wen. Adv. Energy Mater. 11 (31), 2021. DOI: 10.1002/aenm.202101370. 5 Ohno, Saneyuki; Koerver, Raimund; Dewald, Georg; Rosenbach, Carolin; Titscher, Paul; Steckermeier, Dominik; Kwade, Arno; Janek, Jürgen; Zeier, Wolfgang G. Chem. Mater. 31 (8), 2019. DOI: 10.1021/acs.chemmater.9b00282. Figure 1

The science of nutrition focuses primarily on how nutrients contribute to human growth, development, and maintenance. Nutrition is the study of the relationship between diet and health. The goal of healthy nutrition is to keep people in a nutritional state that promotes growth and optimum health. The six to twelve year old school going is a vital time for children's physical and intellectual development. The socioeconomic standing of families, community social well-being, community access to quality healthcare, and environmental influence are all significant determinants of children's health. Malnutrition can be prevented using a variety of strategies if it is seen as a problem in human ecology. This study's goal was to assess the nutritional status of school going children in Nepalgunj, Banke, whose mothers were employed or unemployed and attended selected schools. The study used a descriptive comparative research approach, and 120 students from Nepalgunj, Banke were chosen using stratified random selection. A systematic questionnaire that was self-developed was used to gather the data. The study's findings indicated that children with underweight (51.6%) were more common among children of employed moms than of jobless mothers (20%). However, children of unemployed moms (43.3%) had a higher prevalence of normal weight children than did children of employed mothers (25%). The body mass index (BMI) of the children was found to be correlated with the type of school and maternal job level, with P-values of &lt;0.001 and &lt;0.02 respectively. Children's nutritional status is a critical component of their growth and development. According to this study, children of employed moms were less likely to be underweight, whereas those of jobless mothers were typically sized. Children's BMI was correlated with the work position of the mother and various school kinds, including public and private schools. When developing treatments to improve children's nutritional status, these elements should be taken into account. References Abdel Wahed, W. Y., Hassan, S. K., &amp; Eldessouki, R. (2017). Malnutrition and Its Associated Factors among Rural School Children in Fayoum Governorate, Egypt. Journal of Environmental and Public Health, 2017. https://doi.org/10.1155/2017/4783791 Aryal, M. (2016). Malnutrition in Nepal- an overview. Retrieved from http://umeshg.com.np/malnutrition-in-nepal. Asif, M. (2021). Contingent Effect of Conflict Management towards Psychological Capital and Employees’ Engagement in Financial Sector of Islamabad [PhD Dissertation, Preston University, Kohat, Islamabad Campus.]. Islamabad. Asif, M., Khan, A., &amp; Pasha, M. A. (2019). Psychological Capital of Employees’ Engagement: Moderating Impact of Conflict Management in the Financial Sector of Pakistan. Global Social Sciences Review, IV(III), 160-172. Asser, A. J., &amp; Mohammed, H. J. (2020). Nutritional status of primary school children. Journal of Institute of Medicine Nepal, 20(1). https://doi.org/10.3750/v20/i1/2020/mlu/194732 Best, C., Neufingerl, N., van Geel, L., van den Briel, T., &amp; Osendarp, S. (2010). The Nutritional Status of School-Aged Children: Why Should We Care? Food and Nutrition Bulletin, 31(3), 400–417. https://doi.org/10.1177/156482651003100303 Boma, G. O., Anthony, I. P., George, M. D., Abaiola, E., Andrew, F., Daniel, M. D., Tarilanyo, T. R., &amp; Mefubara, K. (2014). Nutritional Status of Children in Rural setting. IOSR Journal of Dental and Medical Sciences, 13(1), 41–47. https://doi.org/10.9790/0853-13164147 Burgess, A. (2016). Undernutrition in Adults and Children: causes, consequences and what we can do. 18–22. https://www.ajol.info/index.php/ssmj/article/view/132347 C, J. M., Vipul, M., Joshi, H. S., &amp; Professor, A. (2011). Determinants of Nutritional Status of School Children Determinants of Nutritional Status of School Children -A Cross Sectional Study in the Western Region of Nepal. Njirm, 2(1), 2230–9969. Degarege, D., Degarege, A., &amp; Animut, A. (2015). Undernutrition and associated risk factors among school age children in Addis Ababa, Ethiopia. BMC Public Health, 15(1), 375. https://doi.org/10.1186/s12889-015-1714-5 El-Sabely, A. A., Tork, H. M., &amp; Hussien, Y. E. (2013). Comparative study of nutritional status and dietary habits of children from public and private primary schools in Zagazig City, Egypt. IOSR J Nurs Heal Sci, 3(1), 47-52. Eze, J. N., Oguonu, T., Ojinnaka, N. C., &amp; Ibe, B. C. (2017). Physical growth and nutritional status assessment of school children in Enugu, Nigeria. Nigerian Journal of Clinical Practice, 20(1), 64–70. https://doi.org/10.4103/1119-3077.180067 Galgamuwa, L. S., Iddawela, D., Dharmaratne, S. D., &amp; Galgamuwa, G. L. S. (2017). Nutritional status and correlated socio-economic factors among preschool and school children in plantation communities, Sri Lanka. BMC Public Health, 17(1), 377. https://doi.org/10.1186/s12889-017-4311-y Joshi, P. (2012). Malnutrition in Children: A Serious Public Health Issue in Nepal. Health Prospect, 11, 61–62. https://doi.org/10.3126/hprospect.v11i0.7439 Karak, P., Maiti, R., Das, P., &amp; Karmakar, A. (2018). Assessment of nutritional status of School Children in rural and urban areas of Bankura, West bengal. The Indian Journal of Pediatrics, 16(3), 113–152. https://doi.org/10.1007/BF02823216 M, W., B, A., ZB, B., &amp; F, G. (2017). Comparative Study on Nutritional Status of under Five Children with Employment Status of Mothers in Adama Town, Central Ethiopia. Maternal and Pediatric Nutrition, 03(01), 1–8. https://doi.org/10.4172/24721182.1000117 Maskey, M., Sharma Annavarapu, L., &amp; Karmacharya, P. (2020). Nutritional assessment of school children and adolescents: Pokhara city in Western Nepal. Journal of Patan Academy of Health Sciences, 7(2), 53–63. https://doi.org/10.3126/jpahs.v7i2.31115 Ministry of Health and Population (MOHP). (2016). Nepal Demographic and Health Survey. https://dhsprogram.com/pubs/pdf/FR257/FR257%5B13April2012%5D.pdf Mwaniki, E. W., &amp; Makokha, A. N. (2013). Nutrition status and associated factors among children in public primary schools in Dagoretti, Nairobi, Kenya. African health sciences, 13(1), 38-46. Park, K. (2015). A text book of preventive and social medicine. Janot. Pramod Singh, G. C., Nair, M., Grubesic, R. B., &amp; Connell, F. A. (2009). Factors Associated With Underweight and Stunting Among Children in Rural Terai of Eastern Nepal. Asia Pacific Journal of Public Health, 21(2), 144–152. https://doi.org/10.1177/1010539509332063 Sathiadas, G., Annieston, A., Arunath, V., Kasthuri, T., &amp; Wickramasinghe, V. P. (2020). Nutritional status of school children living in Northern part of Sri Lanka. 4–11. https://doi.org/10.21203/rs.3.rs-32024/v1 Shrestha, A., Bhusal, C. K., Shrestha, B., &amp; Bhattarai, K. D. (2020). Nutritional Status of Children and Its Associated Factors in Selected Earthquake-Affected VDCs of Gorkha District, Nepal. International Journal of Pediatrics, 2020, 1–10. https://doi.org/10.1155/2020/5849548 Shahid, N., Asif, M., &amp; Pasha, D. A. (2022). Effect of Internet Addiction on School Going Children. Inverge Journal of Social Sciences, 1(1), 13–55. https://doi.org/10.1022/ijss.v1i1.3 Tim, R., Risk, D., Isbn, C., Pdf, T., Press, N. A., Press, N. A., Academy, N., Academy, N., &amp; Press, N. A. (1990). Diet and health: implications for reducing chronic disease risk. In Choice Reviews Online, 27(06). https://doi.org/10.5860/choice.27-3332 Todhunter, E. N. (1970). School feeding from a nutritionist's point of view. American Journal of Public Health and the Nations Health, 60(12), 2302-2306. Udash, P. (2017). Nutritional status of 5 to 10 years children of namje , vedetar vdc of dhankuta district by pranaya udash Department of Nutrition and Dietetics nutritional status of 5 to 10 years children of namje , vedetar vdc of dhankuta district Department of Nutritio. Umeokonkwo, A. A., Ibekwe, M. U., Umeokonkwo, C. D., Okike, C. O., Ezeanosike, O. B., &amp; Ibe, B. C. (2020). Nutritional status of school age children in Abakaliki metropolis, Ebonyi State, Nigeria. BMC Pediatrics, 20(1), 114. https://doi.org/10.1186/s12887020-1994-5 UNICEF and World Bank. (2014). 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INTRODUCTION. The Bcl-2 inhibitor Venetoclax provides profound reductions in circulating chronic lymphocytic leukemia (CLL) cells in the majority of patients. However, lymph node (LN) responses are less robust, which may be linked to an acquired resistance imposed by pro-survival signals. Prime among these is CD40 stimulation leading to activation of NF-kB, and induction of Bcl-XL expression1. Bcl-XL is a prime determinant of resistance to Venetoclax2 and regulatory mechanisms of its expression are of clinical significance. Cytokines IL-21 and IL-4 are secreted by T helper cells and abundant in the CLL lymph node microenvironment. Importantly, IL-21 and IL-4 play an important role in CLL survival and proliferation3. In the present study, we investigated how signals from T helper cytokines IL-21 or IL-4 affect Bcl-XL expression as a model for the CLL LN microenvironment, specifically in relation to Venetoclax resistance. RESULTS. Following CD40 stimulation, IL-21 and IL-4 show opposing effects on Bcl-XL expression. Correspondingly, this was associated with CD40-induced resistance to Venetoclax which was augmented by IL-4 and reversed by IL-21. We subsequently investigated the rewiring between CD40 activation, differential cytokine signaling and Bcl-XL expression. IL-21 or IL-4 stimulation correspond with differential STAT3 or -6 phosphorylation and STAT3 and -6 have predicted binding sites near the known p65 and p52 binding sites in the Bcl-XL promoter region. Using reporter assays with Bcl-XL promotor constructs we demonstrate competition (through IL-21-induced STAT3) or synergy (through IL-4 induced-STAT6) with CD40-mediated activation of the NF-kB pathway. By applying in situ proximity ligation (isPLA) in primary CLL cells, we showed direct interaction of both (non-)canonical p65 and p52 with STAT3 and STAT6. Moreover, time-course analyses indicated that STAT3 drives NF-kB out of the nucleus, whereas STAT6 keeps NF-kB inside the nucleus, and this distinction controls Bcl-XL expression. These observations suggest that cross-talk between JAK/STAT signaling and NF-kB signaling happens by direct binding to the Bcl-XL promoter and by limiting NF-kB availability at the Bcl-XL promoter. CONCLUSIONS. These data show that protective signals from the CLL microenvironment can be tipped towards apoptosis sensitivity by interfering with JAK/STAT and NF-kB signaling, providing novel therapeutic clues in case of emerging resistance to targeted drugs such as Venetoclax. 1 J. Tromp, S. Tonino, J. Elias, A. Jaspers, D. Luijks, A. Kater, R. van Lier, M. van Oers, E. Eldering. Dichotomy in NF-kB signaling and chemoresistance in IGHV mutated versus unmutated CLL cells upon CD40/TLR9 triggering. Oncogene 2010. 2 R. Thijssen, E. Slinger, K. Weller, C. Geest, T. Beaumont, M. van Oers, A. Kater, E. Eldering. Resistance to ABT-199 induced by microenvironmental signals in chronic lymphocytic leukemia can be counteracted by CD20 antibodies or kinase inhibitors. Haematologica 2015. 3 C. Schleiss, W. Ilias, O. Tahar, Y. Güler, L. Miguet, C. Mayeur-Rousse, L. Mauvieux, L. Fornecker, E. Toussaint, R. Herbrecht, F. Bertrand. M. Maumy-Bertrand, T. Martin, S. Fournel, P. Georgel, S. Bahram, L. Vallat. BCR-associated factors driving chronic lymphocytic leukemia cells in proliferation ex vivo. Scientific Reports 2019. Disclosures Eldering: Celgene: Research Funding; Roche: Research Funding; Janssen Pharmaceutical Companies: Research Funding.

Statement of the problem. An important place in the creative heritage by F. Schmitt (1870–1958) is occupied by music for piano, which in the last decade actively entered to the repertoire of many foreign pianists. At the same time, it remains beyond the focus of Ukrainian performers. From this viewpoint, the relevance of the study is seen in revealing characteristic features of F. Schmitt’s composing style and shaping national musicians’ vision of the creative work of the composer. The purpose of the paper is to fill in the gaps in knowledge about the work of F. Schmitt, to analyze the figurative world of the composer’s piano pieces, to evaluate the influence of cross creative inspirations using the example of the diptych “Mirages”. In this regard, cultural-historical, comparative and structuralfunctional research methods are used. Presentation of the main material. F. Schmitt turned to piano music during all his creative life, leaving more than 30 works, among which cyclic compositions predominate. The range of images is extremely wide: genre scenes, environmental conditions, lyricism, fantasy, etc. Here the influence of impressionism and the art of C. Debussy can be traced. Musicians all over the world were in awe of the talent of this master. Suffice it to recall the unprecedented collaborative work by famous European composers at the turn of the centuries – the multi-genre series of miniatures “Le Tombeau de Claude Debussy”, written in memory of the great creator. F. Schmitt also showed his admiration of the genius of “Claude de France” in the piece “Et Pan, au fond des bles lunaires, s’accouda”. At first, it existed as one of the numbers of “Le Tombeau de Claude Debussy” (1920), and later, together with “La tragique chevauch&amp;#233;e”, it made up the diptych “Mirages” (1921). The poem “Philomela” by a French poet Paul Fort was a kind of inspiring impetus for writing the diptych. The appeal for creative inspiration to related art forms was a frequent occurrence in France at the turn of the 19th and 20th centuries. This took place due to a special cultural environment, marked by a fruitful co-working of writers, artists and musicians. Poets were composed verses inspired by the works of visual art they had seen, artists were created illustrations for literary works that had affected them, composers, in turn, were written music pieces, which embodied poetic images. Paul Fort’s poem have several interwoven semantic plans. In the piece “Et Pan, au fond des bles lunaires, s’accouda” F. Schmitt follows the multiplicity of these plans. On the one hand, he preserves the plot narrative, on the other hand, he emphasizes landscape descriptiveness. According to the content of the poem, the music is divided into episodes, and each of which reveals a new facet of the narrative. This is expressed by a change in pace, key signatures and texture. The sound image of the piece, its texture, metro-rhythm, composition, recording techniques were equally determined both by the inspiration that came from the lines by P. Fort, and by the dedication to the memory of C. Debussy. The piece is characterized by all-encompassing register, juxtaposition of colors, chiaroscuro – the features, by which the musical language of C. Debussy is recognized. At the same time, the contrast of texture, registers and metro-rhythmic complexes involves certain redundancy of information that contradicts the signs of Debussy’s manner of expression, who tended to be more compact and monolithic. This suggests that F. Schmitt creates a kind of anthology of C. Debussy’s legacy, organizing the piece on the principle of stringing small, diverse fragments. Parallels with the cycles “Images”, “Estampes”, and “Pr&amp;#233;ludes” can be noticed in the resulting microsuite composition. In the piece “La tragique chevauch&amp;#233;e” F. Schmitt clearly recreates the spirit of the dramatic events of the poem by George Byron, following the literary plot in music. Two contrasting thematic spheres prevail. The first sphere, which sets the main tone, is characterized by the rapid pace remarked by the author’s notice “Emport&amp;#233; et violent”, a bouncing dotted rhythm, acute accentuation, toccata texture, sudden dynamic changes, dissonant tremolo harmonies. It reflects the outer side of the action – a crazy gallop of a horse running wild with fear, overcoming an endless series of obstacles on the way, and the physical suffering of an exhausted rider. The other one, which is less amplitudinous, is represented by a melancholic, as if crying, cantilena, symbolizing the inner experiences of the tormented hero. The grotesque expressive means in the foreground are a kind of scenery for the action, while the cantilena element, as if remaining in the background, bears the stamp of the inner drama of G. Byron’s poem. Conclusions. Despite the fact that the diptych “Mirages” is not a program composition, the pieces that make it up give rise to vivid, distinct images. Emotional richness, play of timbres, picturesqueness endowed the work with orchestral potential, which drew the attention of contemporaries. At the initiative of S. Koussevitsky, it was instrumented and found a new life on the symphonic stage. It is noteworthy that the eminent conductor’s interest in the timbre side of F. Schmitt’s music did not end there and was realized in “Symphonie Concertante pour piano &amp; orchestra”, op. 82 (1931), written at the request of S. Koussevitsky. This fact opens up new turn in the perspectives for the study of F. Schmitt’s creative work. The symphonic version of the diptych “Mirages” arouses curiosity in terms of the original idea implementation. The composer’s piano works require study taking into account their orchestral potential.