Relevant bibliographies by topics / Gestation pathologie

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  1. Journal articles
  2. Dissertations / Theses
  3. Books
  4. Book chapters
  5. Conference papers

Academic literature on the topic 'Gestation pathologie'

Author: Grafiati
Published: 4 June 2021
Last updated: 1 February 2022

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Journal articles on the topic "Gestation pathologie"

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Hansen, Anne R., Margaret H. Collins, David Genest, Debra Heller, Susan Schwarz, Petra Banagon, Elizabeth N. Allred, and Alan Leviton. "Very Low Birthweight Infant's Placenta and Its Relation to Pregnancy and Fetal Characteristics." Pediatric and Developmental Pathology 3, no. 5 (September 2000): 419–30. http://dx.doi.org/10.1007/s100240010043.

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Our objective was to relate pathology of the very low birthweight (VLBW) infant's placenta to pregnancy and fetal characteristics. We correlated the pathologic features of 1146 placentas from infants with birth weights of 500–1500 g who were born between 1/1/91 and 12/ 31/93 to the number of gestations per pregnancy, initiator of preterm delivery, gestational age, birth weight Z score, and duration of rupture of membrane (ROM). Placental correlates of acute inflammation and villous edema were associated with preterm labor (PTL), pre-labor premature rupture of membranes (PROM), lower gestational age, and higher birth weight Z score. In PTL pregnancies delivered within 1 h of membrane rupture, 61% of placentas already had membrane inflammation. Placental correlates of pregnancy-induced hypertension (PIH) were seen more commonly with PIH pregnancies, older gestational age, and lower birth weight Z score. We found a more prominent histopathologic signature for singleton than for multiple gestation placentas. The placental pathologic findings associated with the clinical diagnoses of infection, PIH, and low–birth weight Z scores in our VLBW/preterm population are similar to those in the literature regarding term pregnancies. The presence of multiple histologic findings consistent with inflammation in placentas of PTL pregnancies with duration of ROM lasting < 1 h suggests that some cases of PTL are precipitated by a more long-standing infection than that previously suspected. Morphologic placental features appear to be correlates of the phenomena leading to premature delivery. Examination of the VLBW infant's placenta provides insight into the etiology and management of VLBW/preterm deliveries.
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Gawron, Lori M., Cassing Hammond, and Linda M. Ernst. "Perinatal Pathologic Examination of Nonintact, Second-Trimester Fetal Demise Specimens: The Value of Standardization." Archives of Pathology & Laboratory Medicine 137, no. 8 (August 1, 2013): 1083–87. http://dx.doi.org/10.5858/arpa.2012-0010-oa.

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Context.—Management of second-trimester intrauterine fetal demise via dilation and evacuation results in nonintact specimens for pathologic examination. Surgical pathology examination is often mandated; however, evidence on expected findings and specimen evaluation guidelines are lacking. Objectives.—To assess pathologic findings of nonintact, second-trimester fetal demise specimens, through comparison of anatomic abnormalities identified on standardized perinatal examination to individualized general pathology examinations. Design.—Single institution, retrospective chart review of 14- to 24-week gestational size fetal demise cases was conducted from May 2006 to October 2010. Suspected abnormalities, chromosomal and pathologic diagnoses were collected. A general surgical pathology examination occurred between May 2006 and October 2008, while a perinatal pathologist examined specimens between October 2008 and October 2010. Statistical analysis consisted of t tests and χ2 tests by Stata/SE 12.1. Results.—One hundred eighteen specimens were included and mean gestational size was 16.0 weeks (standard deviation, 1.6 weeks). Perinatal pathologic evaluation diagnosed significantly more abnormalities than did general pathologic examination (77.3% [34 of 44] versus 9.5% [7 of 75], P &lt; .001). Forty-eight abnormalities were identified: 77.0% (n = 37) were placental and 23.0% (n = 11) were fetal. Chromosomal analysis was done on 73.7% (n = 87 of 118) with 12.6% (n = 11 of 87) showing abnormalities. Among aneuploid specimens, the perinatal pathologist confirmed abnormalities in 66.7% (n = 4 of 6) of cases while general pathologists confirmed abnormalities in 0% (n = 0 of 5) (P = .02). Conclusions.—Systematic surgical pathology examination of nonintact, second-trimester fetal demise specimens yields increased information on fetal or placental abnormalities, which may be clinically useful. Institutions with high-risk obstetrical practices and dilation and evacuation providers should consider integrating a standardized perinatal checklist into educational and practice guidelines.
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Aguinaga, Mónica, Yolotzin Valdespino, Daniela Medina, Salvador Espino y Sosa, Rosalba Sevilla, Osvaldo Miranda, Sandra Acevedo, et al. "Causal analysis of fetal death in high-risk pregnancies." Journal of Perinatal Medicine 49, no. 6 (March 19, 2021): 740–47. http://dx.doi.org/10.1515/jpm-2020-0352.

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Abstract Objectives To determine the causes of fetal death among the stillbirths using two classification systems from 22 weeks of gestation in a period of three years in high-risk pregnancies. This is a retrospective observational study. Methods The National Institute of Perinatal Health in Mexico City is a Level 3 care referral center attending high-risk pregnancies from throughout the country. The population consisted of patients with fetal death during a three-year period. Between January 2016 and December 2018, all stillbirths were examined in the Pathology Department by a pathologist and a medical geneticist. Stillbirth was defined as a fetal death occurring after 22 weeks of gestation. Results Main outcome measures: Causal analysis of fetal death using the International Statistical Classification of Disease and Related Health Problems-Perinatal Mortality (ICD-PM) and initial causes of fetal death (INCODE) classification systems. A total of 297 stillborn neonates were studied. The distribution of gestational age in antepartum stillbirths (55.2%) showed a bimodal curve, 36% occurred between 24 and 27 weeks and 32% between 32 and 36 weeks. In comparison, the majority (86%) of intrapartum deaths (44.8%) were less than 28 weeks of gestation. Of the 273 women enrolled, 93 (34%) consented to a complete fetal autopsy. The INCODE system showed a present cause in 42%, a possible cause in 54% and a probable cause in 93% of patients. Conclusions The principal causes of antepartum death were fetal abnormalities and pathologic placental conditions and the principal causes of intrapartum death were complications of pregnancy which caused a premature labor and infections.
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Franklin, Andrew, Sushmita Yallapragada, Robert Birkett, William Grobman, Linda M. Ernst, and Karen Mestan. "The impact of placental pathology discordance in multiple gestation pregnancies on bronchopulmonary dysplasia-associated pulmonary hypertension." Pulmonary Circulation 10, no. 1 (January 2020): 204589402091067. http://dx.doi.org/10.1177/2045894020910674.

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Bronchopulmonary dysplasia-associated pulmonary hypertension (BPD-PH) may either be concordant or discordant between multiple gestation births. Abnormal placental development, particularly maternal vascular malperfusion, may account for discordance in BPD-PH through fetal programming mechanisms. Maternal vascular malperfusion is a placental histologic lesion associated with intrauterine growth restriction and BPD-PH. We conducted a retrospective longitudinal cohort study of infants born <29 weeks gestation with available placental histology at Prentice Women's Hospital in Chicago from 2005–2012. The primary outcome was discordant BPD-PH associated with placental maternal vascular malperfusion. We secondarily assessed whether the risk of BPD-PH and placental lesions was different among infants of multiple (compared to singleton) gestations. The cohort consisted of 135 multiple gestation infants and 355 singletons. In a separate cohort of 39 singletons and 35 multiples, associations between 12 cytokines and angiogenic growth factors in cord blood plasma for biomarker discordance, maternal vascular malperfusion, and bronchopulmonary dysplasia were explored. Among multiples, discordant maternal vascular malperfusion was not associated with BPD-PH (OR = 1.9 (0.52, 6.9); p = 0.33) in infants exposed to placental maternal vascular malperfusion. However, singleton infants were more likely to develop BPD-PH (compared to multiples) after adjusting for mode of delivery, chorioamnionitis, chronic hypertension, placental abruption, small-for-gestational age birth weight, and gestational age (aOR = 2.7 (1.2, 5.8); p = 0.038). Singletons were more likely to be small-for-gestational age (11% vs 4%, p = 0.025) and have placental lesions compared to their multiple-gestation counterparts (96% vs 81%, p < 0.001), principally severe maternal vascular malperfusion (17% vs 4%, p < 0.001) and chronic inflammation (32% vs 11%, p < 0.001). Increased risk of BPD-PH in singleton pregnancies <29 weeks gestation compared to multiples may be related to increased frequency of these histologic lesions. Placental pathology in singleton and multiple gestation pregnancies may serve as an early biomarker to predict BPD-PH.
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Pinar, Halit, Merielle Stephens, Don B. Singer, Theonia K. Boyd, Solveig M. V. Pflueger, David L. Gang, Drucilla J. Roberts, and C. James Sung. "Triplet Placentas: Reference Values for Weights." Pediatric and Developmental Pathology 5, no. 5 (September 2002): 495–98. http://dx.doi.org/10.1007/s10024-002-0014-0.

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The occurrence of twins, triplets, and other multiple births increased significantly between 1970 and 2000 in the United States and other industrialized countries. The number of triplet placentas submitted for examination as pathologic specimens has also markedly increased, but no reference values are published for triplet weights. We examined 196 normal triplet placentas. Specimens with associated conditions known to affect the weights of the placentas were excluded. The gestational ages ranged between 20 and 38 weeks. Mean weights for different gestational ages are summarized as follows: 253 g for 20 weeks, 319 g for 22 weeks, 406 g for 24 weeks, 509 g for 26 weeks, 621 g for 28 weeks, 738 g for 30 weeks, 855 g for 32 weeks, 965 g for 34 weeks, 1065 g for 36 weeks, and 1147 g for 38 weeks. Weight gain of triplet placentas appears to parallel that of twin placentas. The mean values of placental weights for triplets at each gestational age are less than triple those of singleton weights for the same duration of gestation. The placental weights in multiple gestations do not increase proportionately with the number of fetuses.
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Dugnat, M. "Troubles des conduites alimentaires (TCA) en période périnatale : chez la mère, chez le nourrisson, dans l’interaction." European Psychiatry 29, S3 (November 2014): 611. http://dx.doi.org/10.1016/j.eurpsy.2014.09.227.

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La World Association for Infant Mental Heath (Association Internationale pour la Santé Mentale du Bébé) contribue au développement et à la transmission des connaissances, et à la promotion d’actions cliniques et thérapeutiques en faveur du bébé et de ses parents. Le groupe WAIMH-Francophone, fondé en 1994 par Serge Lebovici et Bernard Golse, insiste sur les aspects psychopathologiques, stimule un réseau francophone de différentes équipes impliquées en psychiatrie périnatale, aide à faire le point sur les travaux en cours et promouvoir un certain nombre de recherches. Plusieurs membres se sont récemment engagés sur les TCA et l’interaction. Les TCA maternels (recherche à la maternité de Port-Royal (APHP) dans le cadre d’un réseau de prise en charge) : Pendant la gestation, la femme change corporellement comme psychiquement. Sous l’effet d’une attention particulière à l‘alimentation des « réactivations » sont possibles lorsqu’elles ont un passé ou un présent de TCA. Une trentaine ont été rencontrées lors des entretiens semi-structurés anténataux puis revues au cours d’un repas avec leur enfant à trois mois, et comparées à d’autres mères sans antécédents. Des résultats préliminaires seront présentés. Les TCA du nourrisson : Après la naissance, l’alimentation est une des préoccupations premières de la mère, les recherches épidémiologiques récentes montrent en clinique pédiatrique ordinaire qu’un quart à un tiers des bébés sont sujets à des difficultés d’alimentation restrictive qui peuvent se transformer en trouble du comportement alimentaire (2 %). Une réflexion sur étiologie et facteurs de chronicisation des TCA précoces contribuant à l’amélioration des modalités de prise en charge pédiatrique, psychologique et rééducative conduira à la présentation d’une consultation conjointe pédiatre/psychologue depuis 4 ans au CHU Toulouse. Les troubles interactionnels : Chez les mères borderlines ou à pathologie des liens, les réponses orales incohérentes lors des pleurs, les réveils intempestifs à motifs alimentaires etc. font de l’alimentation un enjeu crucial de la négligence et de l’interaction pathologique.
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Hyde, Georgia, Andrew Fry, Ashok Raghavan, and Elspeth Whitby. "Biometric analysis of the foetal meconium pattern using T1 weighted 2D gradient echo MRI." BJR|Open 2, no. 1 (November 2020): 20200032. http://dx.doi.org/10.1259/bjro.20200032.

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Objectives: Foetal MRI is used to assess abnormalities after ultrasonography. Bowel anomalies are a significant cause of neonatal morbidity, however there are little data concerning its normal appearance on antenatal MRI. This study aims to investigate the pattern of meconium accumulation throughout gestation using its hyperintense appearance on T1 weighted scans and add to the current published data. Methods: This was a retrospective cohort study in a tertiary referral clinical MRI centre. Foetal body MRI scans of varying gestational ages were obtained dating between October 2011 and March 2018. The bowel was visualised on T1 weighted images. The length of the meconium and the width of the meconium at the rectum, sigmoid colon, splenic flexure and hepatic flexure was measured. Presence or absence of meconium in the small bowel was noted. Inter- and intrarater reliability was assessed. Results: 181 foetal body scans were reviewed. 52 were excluded and 129 analysed. Visualisation of the meconium in the large bowel became increasingly proximal with later gestations, and small bowel visualisation was greater at earlier gestations. There was statistically significant strong (r = 0.6–0.8) or very strong (r = 0.8–1.0) positive correlation of length and width with increasing gestation. Interrater reliability was moderate to excellent (r = 0.4–1.0). Conclusion: This study provides new information regarding the pattern of meconium accumulation throughout gestation. With care, the results can be used in clinical practice to aid diagnosis of bowel pathology. Advances in knowledge: The findings of this study provide further information concerning the normal accumulation of foetal meconium on MR imaging, an area where current research is limited.
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Brenner, Benjamin. "Inherited Thrombophilia and Pregnancy Loss." Thrombosis and Haemostasis 82, no. 08 (1999): 634–40. http://dx.doi.org/10.1055/s-0037-1615890.

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IntroductionA successful pregnancy is dependent on the development of adequate placental circulation. Abnormalities of placental vasculature may result in a number of gestational pathologies, including first and second trimester miscarriages, intrauterine growth retardation (IUGR), intrauterine fetal death (IUFD), placental abruption, and preeclampsia.1 Approximately 5% of women experience two or more consecutive abortions. Habitual abortions, defined as three or more spontaneous recurrent pregnancy losses, may affect as many as 1% to 2% of women of reproductive age. The discovery of an association between recurrent pregnancy loss, and antiphospholipid antibodies, specifically lupus anticoagulant, and anticardiolipin antibodies increased interest in a possible acquired thrombotic autoimmune cause.The inherited thrombophilias are a group of genetic disorders of blood coagulation resulting in an increased risk of thrombosis. Today, a full understanding of the inherited thrombophilias is becoming increasingly important in the management of high-risk gestations. Several reports over the last three years have suggested that not only are these disorders associated with an increased risk of thromboembolic disease during pregnancy and puerperium, but they are also associated with an increased incidence of vascular pathologies, resulting in poor gestational outcome.2 This review will cover recent data concerning thrombophilia and vascular placental pathology, potential pathophysiologic mechanisms for this association, and available therapeutic modalities for prevention of placental vascular thrombosis in order to maximize successful gestational outcome.
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Malinowski, W. "Very Early and Simple Determination of Chorionic and Amniotic Type in Twin Gestations by High-Frequency Transvaginal Ultrasonography." Acta geneticae medicae et gemellologiae: twin research 46, no. 3 (July 1997): 167–73. http://dx.doi.org/10.1017/s0001566000000581.

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AbstractObjective. The aim was to determine the chorionic and amniotic types in multifetal pregnancies with transvaginal ultrasonography at very early stage of gestation.Study design. Twenty-one spontaneous multifetal pregnancies were scanned transvaginally before 8 weeks' gestation (four of them from 4th week). The chorionic and amniotic type was determined ultrasonographically. All twin gestations had postpartum pathologic evaluation of the placenta and histologic determination of the chorionic and amniotic type.Results. Ultrasonographic evaluation of the 21 pregnancies demonstrated 20 twin and 1 triplet gestation. Four of the twin pregnancies were monochorionic-diamniotic. Triplet was monochorionic-triamniotic (spontaneously aborted in 8th week of gestation). In all 20 twin pregnancies, transvaginal ultrasonography correctly predicted the chorionic and amniotic type before 8 weeks of gestation.Conclusion. Transvaginal ultrasonography allows a reliable, simple and rapid determination; the dichorionic twin pregnancy in 4 weeks, monochorionic in 5 weeks, and differentiation of mono-or diamniotic in 7 weeks of gestation.
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Suplotova, Lyudmila Aleksandrovna, S. A. Smetanina, and N. A. Novakovskaya. "Rasprostranennost' metabolicheskogo sindroma i ego komponentov u zhenshchin v razlichnykh etnicheskikh gruppakh." Obesity and metabolism 8, no. 2 (June 15, 2011): 48–51. http://dx.doi.org/10.14341/2071-8713-4952.

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The aim of this work was to evaluate the prevalence of obesity, pathologic weight gain and metabolic syndrome among pregnant women (n=521) in Tyumen Region of Russia. We found that high prevalence of obesity, pathologic gestational weight gain and disturbances of glucose metabolism were increased in non-native than native residents of the studied region. Metabolic syndrome in gestational period is seen very rarely and includes up to three of its components. Women of reproductive age with obesity form the risk group for the development of the metabolic infringement during gestation period. It is necessary to provide specific activities to decrease a body weight among women before pregnancy in order to prevent metabolic disturbances and reproductive losses.
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Dissertations / Theses on the topic "Gestation pathologie"

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Cantón, Germán José. "Immunopathogenesis of bovine neosporosis throughout gestation." Thesis, University of Edinburgh, 2013. http://hdl.handle.net/1842/8798.

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Despite Neospora caninum being recognised as a major cause of bovine abortion, its pathogenesis is only partially understood. Evidence of immune mediated placental pathology has been reported as being responsible for compromising pregnancy probably due to an exacerbated Th1 immune response at the maternal-foetal interface. Different clinical outcomes are known to follow experimental infections at different stages of gestation, with foetal death being the most common finding during early gestation infections, and the birth of live congenitally infected calves following infection in mid or late gestation. The aim of the current study was to characterise the placental cellular immune responses and cytokine expression following experimental Neospora infection during pregnancy. Placentomes were collected from cattle experimentally inoculated with the tachyzoites of the Nc-1 strain during early, mid and late gestation. Inflammation in early gestation was generally moderate to severe. Differently in mid gestation, inflammation was mild to moderate and minimal to mild in late gestation. Generally cellular infiltrates were mainly characterised by the presence of CD3+, CD4+ and γδ T-cells; whereas CD8+ and NK cells were less numerous. Macrophages were detected in larger numbers during later time-points after infection. A moderate to severe infiltration of IL-12, IFN-γ and TNF-α expressing cells was observed in the placentas collected in early gestation. This infiltration was more pronounced in the samples of placentome collected from dams carrying a dead foetus or in those that had aborted, compared with mothers carrying live foetuses at the time of sampling. The distribution of the cellular subsets observed in the three studies was similar. However, cellular infiltrates were more severe following infection during the first trimester in comparison to the second and third trimester. Similarly, the infiltration of Th1 cytokine expressing-cells was more severe in early gestation compared with the milder and more minimal infiltrations observed following N. caninum infection in mid and late gestation, respectively. These results may explain the milder clinical outcome observed when animals are infected in later stages of pregnancy.
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Nguyen, Huu Sau. "Cellules foetales impliquées dans des pathologies inflammatoires et tumorales de la gestation." Paris 6, 2008. http://www.theses.fr/2008PA066204.

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Pendant toute grossesse, des cellules fœtales entrent dans la circulation maternelle et peuvent persister des années après l’accouchement. Les cellules fœtales transférées chez la mère sont des cellules trophoblastiques, des leucocytes, des érythroblastes nucléés, mais aussi des progéniteurs hématopoïétiques ou mésenchymateux. Ces dernières peuvent se nicher dans la moelle osseuse maternelle durant des décennies. La persistance des cellules fœtales a généré deux hypothèses majeures. La présence de cellules foetales semi-allogéniques dans les tissus maternels a tout d’abord suggéré la possibilité de réaction immune anti-maternelles, telles dans la réaction du greffon contre l’hôte. La mise en évidence de cellules fœtales dans quelques maladies auto-immunes, comme la sclérodermie systémique, a largement contribué à soutenir cette hypothèse. Cependant, la capacité observée de greffe et de différentiation de cellules fœtales dans les tissus maternels lésés a amené à formuler l’hypothèse alternative selon laquelle des cellules souches fœtales microchimériques pouvaient participer à la réparation tissulaire maternelle et ne déclenchaient pas de maladie. L’objectif du travail présenté était d’évaluer l’adressage et le phénotype des cellules fœtales chimériques dans la peau maternelle inflammatoire ou tumorale pendant et après la gestation. Nous avons ainsi pu montrer en utilisant divers modèles murins transgéniques et diverses méthodes de détection que des cellules fœtales peuvent effectivement être retrouvées tant dans des dermites de contact que dans des tumeurs cutanées maternelles survenant pendant ou après la gestation. La fréquence de ces cellules était toujours supérieure dans la peau lésée comparée à la peau saine, suggérant un adressage spécifique. Pendant la grossesse, l’évaluation du phénotype des cellules fœtales a pu montrer de façon concordante que la majorité exprimait des marqueurs endothéliaux. Ces cellules se situaient en bordure de vaisseaux ou pouvaient former des vaisseaux entiers. Dans le cas des tumeurs, en utilisant des marqueurs fœtaux indépendants, il a été possible de montrer que les cellules fœtales constituant les parois d’un vaisseau avaient un progéniteur commun. Ces résultats suggèrent fortement l’acquisition par la mère de progéniteurs endothéliaux d’origine fœtale pendant la grossesse. Nous avons également montré la présence de cellules fœtales dans des lésions précancéreuses cutanées survenant longtemps après la gestation. Les cellules fœtales sont détectées dans 75% de ces papillomes cutanés mais jamais dans la peau saine des mêmes souris (p=0,034). Plus d’un tiers des cellules fœtales retrouvées exprimaient le facteur von-Willebrand et 16% étaient des leucocytes. Ces données suggèrent la participation des cellules fœtales au stroma tumoral dès les stades précoces de la carcinogenèse. En conclusion, nos résultats confirment à nouveau la capacité des cellules fœtales à se diriger spécifiquement vers les zones lésées maternelles inflammatoires et tumorales. Nous montrons également pour la première fois les capacités endothéliales de ces cellules chimériques: une grande proportion des cellules fœtales participe à l’angiogénèse. Cela suppose que pendant la grossesse, des progéniteurs endothéliaux d’origine fœtale sont transférés dans la circulation maternelle et recrutés dans les lésions où l’angiogénèse est très importante. La présence de ces cellules pourrait avoir une influence sur l’évolution des pathologies maternelles
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Pascalon, Annette. "Influence des deficits energetiques et proteiques sur l'evolution de la gestation et le taux des acides amines libres chez la ratte : effets sur les concentrations de progesterone et de prolactine aux periodes critiques de la mortalite embryonnaire." Clermont-Ferrand 2, 1988. http://www.theses.fr/1988CLF21092.

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Mjihdi, Abdelkarim. "Capacité de reproduction de la souris et infection aiguë par Trypanosoma cruzi." Doctoral thesis, Universite Libre de Bruxelles, 2004. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/211065.

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Trypanosoma cruzi est un parasite protozoaire à multiplication intracellulaire, agent de la maladie de Chagas, infectant 16 à 18 millions de personnes en Amérique latine. Il peut être transmis de la mère infectée au fœtus dans 2 à 10 % des cas, mais ses autres effets sur la gestation ont été peu étudiés. Par ailleurs, les cytokines ont des effets sur la gestation. Certaines d’entre elles, comme l’interleukine-1, l’IL-4, l’IL-5, l’IL-10, le GM-CSF et le TGF-b2, sont bénéfiques pour la gestation, tandis que d’autres, comme l’IL-2, l’IL-12, l’IFN-g et le TNF-a ont des effets nocifs sur celle-ci. L’impact de l’infection à T. cruzi, stimulant la production de TNF-a et d’IFN-g, sur l'implantation et la croissance fœtale n’a pas été étudié.

Le but de notre travail était d’étudier les effets de l’infection aiguë à T. cruzi sur la capacité de reproduction de la souris. Nous avons ainsi évalué les effets de cette infection sur la fertilité, le développement et la viabilité des fœtus de souris et le rôle de l’IFN-g et du TNF produits au cours de l’infection sur le développement de la gestation.

Nous avons montré que l’infection aiguë à T. cruzi :i) diminue la capacité de reproduction de la souris ;ii) provoque une mortalité fœtale massive précoce (résorptions), tardive et néonatale associée à un retard de croissance intra-utérin, et ce, iii) en dehors de toute transmission congénitale du parasite.

Par ailleurs nos travaux montrent que la mortalité fœtale/néonatale est associée à une invasion parasitaire massive du placenta qui présente d’importantes lésions à type d’infiltrats inflammatoires, de nécrose ischémique, de dépôts de fibrine et de thromboses vasculaires. Nous avons noté qu’il existe une relation inverse entre la charge parasitaire des unités utéro-placentaires et la viabilité du conceptus, suggérant que ces lésions placentaires contribuent à la mortalité fœtale en limitant les échanges materno-fœtaux.

Enfin, nous avons également étudié le rôle de cytokines abortogènes comme le TNF et l’IFN-g, produites abondamment pendant l’infection aiguë de la souris par T. cruzi. Les taux sanguins maternels d’IFN-g étaient augmentés au 9ième mais pas aux 17ième et 19ième jours de gestation, alors que les taux de TNF sanguin et la production placentaire de cette cytokine augmentaient aux 17ième et 19ième jours de gestation. Afin d’évaluer le rôle de ces deux cytokines dans la mortalité fœtale, des souris ont été traitées par la pentoxifylline, pour inhiber la transcription du gène de TNF-a et diminuer la production d’IFN-g. Ces souris montraient une réduction de la mortalité fœtale à mi-gestation, associée à une diminution de la production du TNF placentaire, sans modifications des taux systémiques et sans effets sur l’IFN-g, suggérant la contribution du TNF dans la mortalité fœtale associée à l’infection aiguë par T. cruzi.

En conclusion, notre travail montre que l’infection aiguë à Trypanosoma cruzi exerce un effet particulièrement néfaste sur la capacité de reproduction et le développement de la gestation chez la souris et que les lésions placentaires liées à l’infection et la production de TNF par le placenta infecté contribuent à cet effet.


Doctorat en sciences biomédicales
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Tsai, Ya-Fang. "Inflammation and Altered Signaling in Obstetric Pathologies." BYU ScholarsArchive, 2021. https://scholarsarchive.byu.edu/etd/9215.

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The purpose of this research project was to elucidate the molecular interactions and detail the signaling pathways in obstetric pathologies. This work first seeks to understand inflammation related complications relevant to obstetrics. Prior research in our lab identified the implications of the receptor of advanced glycation end products (RAGE) during inflammatory response in the placenta. Current work identified the presence of DNA double-strand breaks (DNA-DSBs) in inflammation associated pregnancy complications of preeclampsia (PE) and preterm labor (PTL) and demonstrated the positive role of RAGE in repairing the damage. The confluent relevance of disrupted mitochondrial function and inflammation has been recognized in the etiology of numerous chronic diseases. Our current studies aim to understand the connections between energy metabolism and inflammation in pathologies of pregnancy complications. Previous research conducted in our laboratory has demonstrated the mediation of the Gas6/Axl pathway on the mechanistic target of rapamycin (mTOR), an important metabolic molecule. We observed the negative regulation of Gas6 treatment on the mTOR pathway and its negative effects on trophoblast cell invasion. In the current study looking at the aspect of energy regulation, we identified the activation of placental mTOR in gestational diabetes mellitus (GDM) and its decrease during PE and intrauterine growth restriction (IUGR). We further evaluated the regulation of mTOR on its downstream effector pyruvate kinase M2 (PKM2). We found that inhibition of mTOR decreased PKM2 activation; while PKM2 activation positively regulated trophoblastic invasion and rescued negative effects observed in our second-hand smoke IUGR murine model. Our work has opened a new direction of placental research, especially in pregnancy complications stemming from genomic instability. We also clarified details of mTOR and PKM2 meditated metabolic signaling that are crucial for future investigation on the dynamic metabolic regulation during pregnancy.
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Costet-Deiber, Nathalie. "Effets sanitaires de l'exposition aux sous-produits de chloration de l'eau." Phd thesis, Université Rennes 1, 2013. http://tel.archives-ouvertes.fr/tel-00927735.

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Contexte. La chloration est le traitement le plus utilisé pour désinfecter l'eau distribuée à la population. Lors du traitement, des sous-produits de chloration (SPCs) se forment par réaction de la matière organique naturelle présente dans l'eau avec le chlore. Les produits les plus présents sont les trihalométhanes (THMs), les acides haloacétiques (HAAs). Des études toxicologiques (animales et in vitro) ont montré la génotoxicité et/ou carcinogénicité et la reprotoxicité de certains SPCs. Nous avons mené deux études évaluant les effets sur la santé humaine de l'exposition aux SPCs, dans le domaine du cancer et de la reproduction. Association entre exposition aux THMs et risque de cancer de la vessie : une analyse poolée de 3 études cas-témoins européennes. Cette analyse a inclus 2381 cas et 3086 témoins issus de 3 études cas-témoins (France, Espagne, Finlande). L'exposition environnementale aux SPCs a été mesurée par la concentration en THMs estimée rétrospectivement dans les réseaux de distribution d'eau au cours des 40 années de la fenêtre d'exposition. Les usages de l'eau connus sont l'ingestion, les douches et les bains, la fréquentation de piscine (étude espagnole seulement). Une relation croissante a été observée entre le niveau environnemental de THMs, la durée d'exposition à une eau de surface chlorée et le risque de cancer de la vessie, chez les hommes uniquement. Aucune association n'a été observée avec l'exposition via l'ingestion d'eau du robinet. L'exposition via les douches, les bains et la piscine est apparue liée au risque de cancer de la vessie. Trois études cas-témoins nord-américaines ont été intégrées dans une méta-régression. Aucune spécificité européenne de la relation dose-réponse n'a été mise en évidence. Une relation dose-réponse globale incluant 4351 cas et 7055 témoins a été estimée. Association entre exposition aux SPCs et risque de prématurité et de retard de croissance intra-utérin (RCIU). Cette étude est issue de la cohorte bretonne Pélagie (3400 femmes enceintes recrutées en début de grossesse entre 2002 et 2006). L'exposition pendant la grossesse a été mesurée à l'aide de 2 indicateurs : la concentration en THMs de l'eau distribuée dans les réseaux et le dosage d'un biomarqueur urinaire (acide trichloroacétique) pour un sous-échantillon de femmes (étude cas-témoins nichée). Les niveaux dans les réseaux proviennent de la base de données réglementaire SISE-Eaux. Les usages de l'eau du robinet par les femmes pendant la grossesse ont été collectés par questionnaire (quantité d'eau du robinet bue, fréquentation de la piscine, fréquence et durée des douches et des bains). Notre étude suggère une association entre l'exposition prénatale aux SPCs et le risque de RCIU. Aucune association n'est observée avec le risque de prématurité.
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Widdows, Kate Louise. "Gestational related morphological abnormalities in placental villous trophoblast turnover in compromised pregnancies." Thesis, Brunel University, 2009. http://bura.brunel.ac.uk/handle/2438/4444.

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Human placental villi are covered by a layer of trophoblast epithelia in direct contact with maternal blood, which exist in a constant steady-state of turnover and renewal ensuring both maternal and fetal health. The process of trophoblast turnover involves proliferation, differentiation and fusion of cytotrophoblast cells to form a terminally differentiated outer syncytiotrophoblast layer which functions as the active transport compartment between mother and fetus. Alterations in the balance between these three processes are thought to diminish both the structural and functional integrity of the syncytiotrophoblast, potentially leading to placental insufficiency associated with severe complications of pregnancy such as pre-eclampsia (PET), intrauterine growth restriction (IUGR) and sudden infant death syndrome (SIDS). Placentas from early (<32 weeks) and late-onset (>33 weeks) pregnancies complicated by PET, IUGR, SIDS and gestational age-matched controls were systematically uniform randomly sampled to assess the morphological basis of placental villous structure and trophoblast turnover (villi, cytotrophoblast, syncytiotrophoblast, apoptotic syncytial knots) using unbiased stereological techniques (volumes and numbers). Villous cytotrophoblast proliferation was assessed using double immunohistochemistry for Ki67 and cytokeratin 7 (CK-7). Severe early-onset IUGR placentas (n=5) were smaller displaying significant reductions in the total number of CT cells, within which the density of proliferating CT was further reduced by 50%. Syncytiotrophoblast volume and number was significantly reduced with an increase in apoptotic syncytial knots. Late-onset IUGR placentas (n=4) also displayed significant reductions in the total number of CT and proliferating CT, but were not associated with changes in the density of proliferating CT. SCT numbers were significantly reduced with an increase in apoptotic knots. Placentas from severe early-onset PET (n=11) were similar to preterm controls, except for a significant increase in apoptotic syncytial knots. However, late-onset PET (n=6) displayed a significant decrease in total CT number, the percentage of which undergoing proliferation was significantly increased for structural villi. There were increased numbers of apoptotic syncytial knots in peripheral villi.
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8

Compagnon, Anne. "Étude des malformations induites par la pyriméthamine chez le rat : anomalies du développement de la région faciale." Paris 6, 1987. http://www.theses.fr/1987PA060631.

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Polettini, Jossimara [UNESP]. "Análise quantitativa da expressão de citocinas inflamatórias em membranas corioamnióticas de gestantes com rotura prematura de membranas pré-termo." Universidade Estadual Paulista (UNESP), 2007. http://hdl.handle.net/11449/98434.

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Made available in DSpace on 2014-06-11T19:29:34Z (GMT). No. of bitstreams: 0 Previous issue date: 2007-02-16Bitstream added on 2014-06-13T19:59:17Z : No. of bitstreams: 1 polettini_j_me_botfm.pdf: 2194860 bytes, checksum: a731ea318ab122b9bf8331b8c84cfef9 (MD5)
Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
A Rotura Prematura de Membranas Pré-Termo (RPM-PT) é um dos principais problemas da Clínica Obstétrica, com etiologia relacionada à ascensão bacteriana do trato genital inferior para a decídua e membranas corioamnióticas. Objetivo: quantificar a expressão das citocinas inflamatórias interleucina (IL) -1b, IL-6, IL-8 e fator de necrose tumoral (TNF-a) pelas membranas corioamnióticas de gestantes com RPM-PT, e avaliar a correlação dessa expressão com a presença e intensidade do infiltrado inflamatório nas membranas e decídua. Material e Métodos: Foram incluídas no estudo, 25 gestantes com RPM-PT em trabalho de parto e 15 gestantes com RPM-PT fora do trabalho de parto. Como grupo controle foram avaliadas 25 gestantes em trabalho de parto prematuro (TPP) e bolsa íntegra. No momento da resolução da gestação, após a dequitação, foram retirados fragmentos das membranas corioamnióticas e acondicionados em RNA later para posterior quantificação do RNA mensageiro (RNAm) das citocinas inflamatórias pela técnica de PCR em tempo real. Outros fragmentos das membranas foram submetidos à análise histopatológica para avaliação da presença e semi-quantificação do infiltrado inflamatório. Resultados: No período do estudo, a incidência de RPM-PT foi de 4,6%. A presença de infiltrado inflamatório nas membranas corioamnióticas e/ou decídua foi de 75% no grupo RPM-PT. A concentração relativa de RNAm de IL-1b, IL-6 e IL-8 não foi estatisticamente diferente nos grupos estudados. Para TNF-a, a concentração relativa de RNA foi estatisticamente superior nas membranas de gestantes com TPP em relação aos grupos com RPM-PT. Na presença de infiltrado inflamatório nas membranas corioamnióticas, a concentração de RNAm de IL-1b foi estatisticamente maior no grupo RPM-PT fora de trabalho de parto...
The preterm premature rupture of membranes (PPROM) is one of the major problems of Clinical Obstetrics. Its etiology is related to the ascending pathway of bacteria from the lower genital tract to the decidua and chorioamniotic membranes. Objective: To quantify the expression of the inflammatory cytokines interleukin-1 (IL) -1b, IL-6, IL-8 and tumor necrosis factor alpha (TNF-a) in the chorioamniotic membranes of pregnant women with PPROM and evaluate the correlation of this expression with the presence and intensity of the inflammatory infiltrates present in the membranes and decidua. Material and Methods: Twenty-five PPROM women in labor and 15 PPROM without labor women were studied. As a control group of 25 pregnant women in premature labor (PTL) were studied. After delivery, samples of the chorioamniotic membranes were collected for histopathological analyses and others fragments were conditioned in RNA later for posterior quantification of cytokine mRNA expression by real time PCR. Results: In the study period, the incidence of PPROM was 4.6% and in 75% of these samples the presence of inflammatory infiltrates in the chorioamniotic membranes and/or decidua was observed. mRNA expression of IL-1b, IL-6 and IL-8 was not statistically different in the groups studied. For TNF-a, the expression of mRNA was statistically higher in the PTL group in relation to the groups with PPROM. In the presence of inflammatory infiltrates in the membranes, the concentration of mRNA of IL- 1b it was statistically greater in the PPROM without labor group. No difference occurred in the intensity of cytokine mRNA in relation to the intensity of the infiltrated inflammatory in the groups studied. In 87.2% of the chorioamniotic membranes included in the study, mRNA was expressed for all the cytokines studied... (Complete abstract, click electronic access below)
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Polettini, Jossimara. "Análise quantitativa da expressão de citocinas inflamatórias em membranas corioamnióticas de gestantes com rotura prematura de membranas pré-termo /." Botucatu : [s.n.], 2007. http://hdl.handle.net/11449/98434.

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Orientador: Márcia Guimarães da Silva
Banca: Maria Terezinha Serrão Peraçoli
Banca: José Antonio Simões
Resumo: A Rotura Prematura de Membranas Pré-Termo (RPM-PT) é um dos principais problemas da Clínica Obstétrica, com etiologia relacionada à ascensão bacteriana do trato genital inferior para a decídua e membranas corioamnióticas. Objetivo: quantificar a expressão das citocinas inflamatórias interleucina (IL) -1b, IL-6, IL-8 e fator de necrose tumoral (TNF-a) pelas membranas corioamnióticas de gestantes com RPM-PT, e avaliar a correlação dessa expressão com a presença e intensidade do infiltrado inflamatório nas membranas e decídua. Material e Métodos: Foram incluídas no estudo, 25 gestantes com RPM-PT em trabalho de parto e 15 gestantes com RPM-PT fora do trabalho de parto. Como grupo controle foram avaliadas 25 gestantes em trabalho de parto prematuro (TPP) e bolsa íntegra. No momento da resolução da gestação, após a dequitação, foram retirados fragmentos das membranas corioamnióticas e acondicionados em RNA later para posterior quantificação do RNA mensageiro (RNAm) das citocinas inflamatórias pela técnica de PCR em tempo real. Outros fragmentos das membranas foram submetidos à análise histopatológica para avaliação da presença e semi-quantificação do infiltrado inflamatório. Resultados: No período do estudo, a incidência de RPM-PT foi de 4,6%. A presença de infiltrado inflamatório nas membranas corioamnióticas e/ou decídua foi de 75% no grupo RPM-PT. A concentração relativa de RNAm de IL-1b, IL-6 e IL-8 não foi estatisticamente diferente nos grupos estudados. Para TNF-a, a concentração relativa de RNA foi estatisticamente superior nas membranas de gestantes com TPP em relação aos grupos com RPM-PT. Na presença de infiltrado inflamatório nas membranas corioamnióticas, a concentração de RNAm de IL-1b foi estatisticamente maior no grupo RPM-PT fora de trabalho de parto... (Resumo completo, clicar acesso eletrônico abaixo)
Abstract: The preterm premature rupture of membranes (PPROM) is one of the major problems of Clinical Obstetrics. Its etiology is related to the ascending pathway of bacteria from the lower genital tract to the decidua and chorioamniotic membranes. Objective: To quantify the expression of the inflammatory cytokines interleukin-1 (IL) -1b, IL-6, IL-8 and tumor necrosis factor alpha (TNF-a) in the chorioamniotic membranes of pregnant women with PPROM and evaluate the correlation of this expression with the presence and intensity of the inflammatory infiltrates present in the membranes and decidua. Material and Methods: Twenty-five PPROM women in labor and 15 PPROM without labor women were studied. As a control group of 25 pregnant women in premature labor (PTL) were studied. After delivery, samples of the chorioamniotic membranes were collected for histopathological analyses and others fragments were conditioned in RNA later for posterior quantification of cytokine mRNA expression by real time PCR. Results: In the study period, the incidence of PPROM was 4.6% and in 75% of these samples the presence of inflammatory infiltrates in the chorioamniotic membranes and/or decidua was observed. mRNA expression of IL-1b, IL-6 and IL-8 was not statistically different in the groups studied. For TNF-a, the expression of mRNA was statistically higher in the PTL group in relation to the groups with PPROM. In the presence of inflammatory infiltrates in the membranes, the concentration of mRNA of IL- 1b it was statistically greater in the PPROM without labor group. No difference occurred in the intensity of cytokine mRNA in relation to the intensity of the infiltrated inflammatory in the groups studied. In 87.2% of the chorioamniotic membranes included in the study, mRNA was expressed for all the cytokines studied... (Complete abstract, click electronic access below)
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Books on the topic "Gestation pathologie"

1

Gestational trophoblastic disease: Diagnostic and molecular genetic pathology. New York: Springer, 2012.

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Redline, Raymond W., Theonia K. Boyd, and Drucilla J. Roberts. Placental and Gestational Pathology. University of Cambridge ESOL Examinations, 2018.

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Redline, Raymond W., Theonia K. Boyd, and Drucilla J. Roberts, eds. Placental and Gestational Pathology. Cambridge University Press, 2017. http://dx.doi.org/10.1017/9781316848616.

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Hui, Pei. Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology. Humana Press, 2011.

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Hui, Pei. Gestational Trophoblastic Disease: Diagnostic and Molecular Genetic Pathology. Humana Press, 2016.

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Silverberg, Steven G. Tumors of the Uterine Corpus and Gestational Trophoblastic Disease (Atlas of Tumor Pathology 3rd Series). American Registry of Pathology, 1992.

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WHO Classification of Tumours of the Female Reproductive Organs. World Health Organization, 2014.

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Book chapters on the topic "Gestation pathologie"

1

Baergen, Rebecca N. "Multiple Gestation: General Aspects." In Manual of Pathology of the Human Placenta, 121–39. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7494-5_9.

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Khong, T. Yee, Annie N. Y. Cheung, and Wenxin Zheng. "Gestational trophoblastic disease." In Diagnostic Endometrial Pathology, 1–50. 2e. | Boca Raton : CRC Press, 2018. | Preceded by Handbook of endometrial pathology / T. Yee Khong, Sezgin M. Ismail. 2005.: CRC Press, 2019. http://dx.doi.org/10.1201/9781315228686-10.

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Buza, Natalia, and Pei Hui. "Gestational Trophoblastic Diseases." In Practical Gynecologic Pathology, 173–91. Cham: Springer International Publishing, 2021. http://dx.doi.org/10.1007/978-3-030-68608-6_7.

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Heller, Debra S. "Gestational Trophoblastic Neoplasia." In OB-GYN Pathology for the Clinician, 215–27. Cham: Springer International Publishing, 2015. http://dx.doi.org/10.1007/978-3-319-15422-0_13.

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Mazur, Michael T., and Robert J. Kurman. "Gestational Trophoblastic Disease." In Blaustein’s Pathology of the Female Genital Tract, 835–75. New York, NY: Springer New York, 1987. http://dx.doi.org/10.1007/978-1-4757-1942-0_24.

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Chhieng, David, and Pei Hui. "Gestational Trophoblastic Disease." In Cytology and Surgical Pathology of Gynecologic Neoplasms, 131–38. Totowa, NJ: Humana Press, 2010. http://dx.doi.org/10.1007/978-1-60761-164-6_8.

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Redline, Raymond W. "Placenta and Gestational Trophoblastic Disease." In Essentials of Anatomic Pathology, 1097–116. Totowa, NJ: Humana Press, 2006. http://dx.doi.org/10.1007/978-1-60327-173-8_27.

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Redline, Raymond W. "Placenta and Gestational Trophoblastic Disease." In Essentials of Anatomic Pathology, 1431–53. New York, NY: Springer New York, 2010. http://dx.doi.org/10.1007/978-1-4419-6043-6_33.

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Redline, Raymond W. "Placenta and Gestational Trophoblastic Disease." In Essentials of Anatomic Pathology, 1589–610. Cham: Springer International Publishing, 2016. http://dx.doi.org/10.1007/978-3-319-23380-2_33.

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Baergen, Rebecca N. "Multiple Gestation: Twin Variants and Related Conditions." In Manual of Pathology of the Human Placenta, 141–62. Boston, MA: Springer US, 2010. http://dx.doi.org/10.1007/978-1-4419-7494-5_10.

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Conference papers on the topic "Gestation pathologie"

1

Daffos, F., F. Forestier, C. Kaplan, and J. Y. Muller. "PERNATAL MANAGEMENT OF FETAL THROMBOCYTOPENIA." In XIth International Congress on Thrombosis and Haemostasis. Schattauer GmbH, 1987. http://dx.doi.org/10.1055/s-0038-1644272.

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Fetal thrombocytopenia resulting from alloimmunisation (NAIT] or from autoimmune pathology (ITP) may contribute to morbidity from hemorrhage particularly when bleeding occurs into the central nervous system.Utilizing a safe procedure for in utero blood samplings i.e. directpuncture under ultrasound guidance, we are able to propose a prenatal management. Considering NAIT we haveuntil now treated 6 patients. We propose a screening protocol for highrisk group based on maternal antecedents and immunological grounds. Fetal blood sampling is performed at 20th week of gestation allowing platelet count and typing. If there isincompatibility between the fetus and his mother two ways can be consFdered : absence or presence of thrombocytopenia. If the platelet countis normal, nothing is done until 37th week of gestation. In the other case, frequent ultrasound examinations are done. At the 37e week, a fetal blood sampling is performed andin utero maternal platelet transfusion is done in the case of thrombocytopenia, before the delivery. It is possible with this prenatal treatment to have vaginal delivery. Considering ITP. when the maternal status permit it. fetal blood samplingslet us to know exactly the fetal platelet count. By this way. the indication of delivery can be documented.This procedure offers a new possibility of easily taking iterative samples. until the end of pregnancyand represents a particular interest in the prenatal treatment of suchhemorrhagic disorders.
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Pandher, Dilpreet K. "To find the prevalence of female genital tract malignancies in a tertiary care hospital." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685376.

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Genital tract and breast are two most common sites of malignancy in females. Out of the genital tract malignancies, carcinoma cervix is so far found to be the commonest followed by ovary and endometrium. In developed countries, carcinoma cervix incidence is comparatively quite low due to good regular screening of females. One year review of patients was done, who underwent definitive/debulking surgery for a diagnosed malignant pathology of the genital tract, in obstetrics and gynaecology department of Govt medical College and Hospital, Chandigarh. Total 62 patients were operated, most common indication was carcinoma ovary, followed by endometrial cancer, cancer cervix and gestational trophoblastic neoplasia. 166 patients underwent biopsies for suspicious symptoms or the abnormal findings on examination and the patients with final malignancy report were either operated as described above and the inoperable cases were referred to oncotherapy department for further management.
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Pandher, Dilpreet K. "To find the prevalence of female genital tract malignancies in a tertiary care hospital." In 16th Annual International Conference RGCON. Thieme Medical and Scientific Publishers Private Ltd., 2016. http://dx.doi.org/10.1055/s-0039-1685349.

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Genital tract and breast are two most common sites of malignancy in females. Out of the genital tract malignancies, carcinoma cervix is so far found to be the commonest followed by ovary and endometrium. In developed countries, carcinoma cervix incidence is comparatively quite low due to good regular screening of females. One year review of patients was done, who underwent definitive/debulking surgery for a diagnosed malignant pathology of the genital tract, in obstetrics and gynaecology department of Govt. medical College and Hospital, Chandigarh. Total 62 patients were operated, most common indication was carcinoma ovary, followed by endometrial cancer, cancer cervix and gestational trophoblastic neoplasia. 166 patients underwent biopsies for suspicious symptoms or the abnormal findings on examination and the patients with final malignancy report were either operated as described above and the inoperable cases were referred to oncotherapy department for further management.
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Suelmann, Britt BerendineMaria, Carmen van Dooijeweert, Carsten Bakhuis, Elsken van der Wall, Sabine Linn, and Paul van Diest. "Abstract PS7-14: The histopathologic profile of pregnancy associated breast cancer by gestational age and lactation: Analysis of the nationwide Dutch Pathology Registry." In Abstracts: 2020 San Antonio Breast Cancer Virtual Symposium; December 8-11, 2020; San Antonio, Texas. American Association for Cancer Research, 2021. http://dx.doi.org/10.1158/1538-7445.sabcs20-ps7-14.

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