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Relevant bibliographies by topics / High-throughput compound screening / Dissertations / Theses

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Dissertations / Theses on the topic 'High-throughput compound screening'

Author: Grafiati

Published: 4 June 2021

Last updated: 6 February 2022

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1

Brehm, Marius [Verfasser], and P. [Akademischer Betreuer] Levkin. "Miniaturized and Parallel Synthesis of Compound Libraries for High-Throughput On-Chip Screening on Hydrophilic-Hydrophobic Patterned Surfaces / Marius Brehm ; Betreuer: P. Levkin." Karlsruhe : KIT-Bibliothek, 2021. http://d-nb.info/123507241X/34.

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Hinrichs, Wilko [Verfasser], Klaus-Armin [Akademischer Betreuer] Nave, Martin [Akademischer Betreuer] Göpfert, André [Akademischer Betreuer] Fischer, and Moritz [Akademischer Betreuer] Rossner. "A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia / Wilko Hinrichs. Gutachter: Martin Göpfert ; André Fischer ; Moritz Rossner. Betreuer: Klaus-Armin Nave." Göttingen : Niedersächsische Staats- und Universitätsbibliothek Göttingen, 2012. http://d-nb.info/1044869100/34.

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Malo, Nathalie. "Statistical contributions to data analysis for high-throughput screening of chemical compounds." Thesis, McGill University, 2006. http://digitool.Library.McGill.CA:80/R/?func=dbin-jump-full&object_id=102680.

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High-throughput Screening (HTS) is a relatively new process which allows several thousand chemical compounds to be tested rapidly in order to identify their potential as drug candidates. Despite increasing numbers of promising candidates, however, the numbers of new compounds that ultimately reach the market have declined. One way to improve upon this situation is to develop efficient and accurate data processing and statistical testing methods tailored for HTS. Human, biological or mechanical errors may develop across the several days it takes to run the entire screen and cause unwanted varia

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Barker, Samuel Peter. "Early stage drug discovery screening for novel compounds active against the persister phenotype in Burkholderia thailandensis." Thesis, University of Exeter, 2016. http://hdl.handle.net/10871/26236.

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Many pathogenic microorganisms are believed to stochastically switch into low metabolic states that display resistance to supra-lethal levels of antibiotics. These so-called “persister” cells have been associated with recurrent infections and the development of antibiotic resistance. Whilst a compound that eliminates Staphylococcus aureus persister cells has been described, it is not active against Gram-negative bacteria. The aim of my PhD project was to develop a high-throughput assay for compounds that eradicate persister cells in the -proteobacterium Burkholderia thailandensis. Further to

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5

Nishihara, Kana. "Identification of Genotoxic Compounds Using Isogenic DNA Repair Deficient DT40 Cell Lines on a Quantitative High Throughput Screening Platform." Kyoto University, 2016. http://hdl.handle.net/2433/215414.

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This is a pre-copyedited, author-produced PDF of an article accepted for publication in Mutagenesis following peer review. The definitive publisher-authenticated version is available online at:http://mutage.oxfordjournals.org/content/early/2015/08/03/mutage.gev055.full.<br>Kyoto University (京都大学)<br>0048<br>新制・課程博士<br>博士(医学)<br>甲第19588号<br>医博第4095号<br>新制||医||1014(附属図書館)<br>32624<br>京都大学大学院医学研究科医学専攻<br>(主査)教授小泉昭夫, 教授渡邊直樹, 教授高田穣<br>学位規則第4条第1項該当

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6

Shubbar, Ahmed. "Novel neuroprotective compounds for use in Parkinson's disease." Kent State University / OhioLINK, 2013. http://rave.ohiolink.edu/etdc/view?acc_num=kent1384806955.

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7

Hoffmann, Hans-Heinrich [Verfasser]. "The identification of novel antivirals and enhancers of influenza virus replication via high-throughput screening of small molecular weight compounds / Hans-Heinrich Hoffmann." Berlin : Freie Universität Berlin, 2011. http://d-nb.info/1025354036/34.

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8

Vazquez, Ana Carolina. "Identification and characterization of compounds with antiviral activity against influenza viruses." [Kent, Ohio] : Kent State University, 2008. http://rave.ohiolink.edu/etdc/view?acc%5Fnum=kent1227644336.

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Thesis (Ph.D.)--Kent State University, 2008.<br>Title from PDF t.p. (viewed Dec. 14, 2009) Advisor: Miguel E. Quinones-Mateu. Keywords: biomedical research, cellular biology, molecular biology, virology. Includes bibliographical references (p. 201-228)

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Aftab, Obaid. "Towards High-Throughput Phenotypic and Systemic Profiling of in vitro Growing Cell Populations using Label-Free Microscopy and Spectroscopy : Applications in Cancer Pharmacology." Doctoral thesis, Uppsala universitet, Cancerfarmakologi och beräkningsmedicin, 2014. http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-234565.

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Modern techniques like automated microscopy and spectroscopy now make it possible to study quantitatively, across multiple phenotypic and molecular parameters, how cell populations are affected by different treatments and/or environmental disturbances. As the technology development at the instrument level often is ahead of the data analytical tools and the scientific questions, there is a large and growing need for computational algorithms enabling desired data analysis. These algorithms must have capacity to extract and process quantitative dynamic information about how the cell population is

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10

Hsieh, Meng-Lun, and 謝孟倫. "Identification of small-molecule human PTGR-2 inhibitor through high-throughput compound screening." Thesis, 2017. http://ndltd.ncl.edu.tw/handle/11717556324919987625.

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碩士<br>國立臺灣大學<br>基因體暨蛋白體醫學研究所<br>105<br>Peroxisome proliferator-activated receptor γ (PPARγ) is a master regulator of whole-body energy metabolism, glucose homeostasis, and insulin resistance mainly expressed in adipose tissue. PPARγ acts through transcriptional regulation of genes involved in glucose and energy homeostasis upon ligand binding. The widely used anti-diabetic agent thiazolidinediones (TZD) are potent synthetic PPARγ agonist. However, most PPARγ agonists are associated with significant side effects, such as water retention, increased adiposity, and osteoporosis. There is an urgent

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11

Kung, Fang-Yen, and 龔芳彥. "High throughput screening identified an alkaloid compound that potently inhibits replication of enterovirus 71." Thesis, 2013. http://ndltd.ncl.edu.tw/handle/59350553453328135024.

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碩士<br>國立陽明大學<br>醫學生物技術暨檢驗學系<br>101<br>Enterovirus 71 (EV71), a member of the genus Enterovirus of the family Picornaviridae, is a common pathogen often associated with mild foot-and-mouth disease and occasionally severe neurological manifestations in young children. However, there have been no anti-EV71 drugs available for clinical use. Several strategies for anti-EV71 drug development have been employed, ranging from viral target-based design, compound screening, and compound series generated from antiviral developments against related poliovirus and human rhinoviruses. All these efforts excl

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12

Ng, Belinda Ling Nah. "High-throughput assays for biotin protein ligase: a novel antibiotic target." 2009. http://hdl.handle.net/2440/57451.

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Antibiotics are defined as chemical substances that inhibit or limit the growth of microorganisms. Since the second world war, antibiotics have been widely used to reduce the morbidity and mortality associated with serious bacterial infections caused by organisms such as Staphylococcus aureus. However, it has become increasingly difficult to treat bacterial infections due to the emergence of antibiotic resistant strains. The first clinical case of drug resistant bacteria was observed in S. aureus in 1947, just four years after the mass production of penicillin. Since then, resistance has been

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13

Hinrichs, Wilko. "A cell-based NRG1-ERBB4 assay designed for high-throughput compound screening to identify small molecule modulators with relevance for schizophrenia." Doctoral thesis, 2012. http://hdl.handle.net/11858/00-1735-0000-000D-EF8B-7.

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14

Soufan, Othman. "Novel Data Mining Methods for Virtual Screening of Biological Active Chemical Compounds." Diss., 2016. http://hdl.handle.net/10754/621873.

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Drug discovery is a process that takes many years and hundreds of millions of dollars to reveal a confident conclusion about a specific treatment. Part of this sophisticated process is based on preliminary investigations to suggest a set of chemical compounds as candidate drugs for the treatment. Computational resources have been playing a significant role in this part through a step known as virtual screening. From a data mining perspective, availability of rich data resources is key in training prediction models. Yet, the difficulties imposed by big expansion in data and its dimensionality a

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15

Cheng, Wei-Ling, and 鄭惟齡. "High-throughput Screening for Novel Compounds Which Increase the SMN2 mRNA Exon7 Inclusion in Spinal Muscular Atrophy Cells." Thesis, 2007. http://ndltd.ncl.edu.tw/handle/80821075794697118533.

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碩士<br>高雄醫學大學<br>醫學研究所碩士班<br>95<br>Spinal muscular atrophy (SMA) is an autosomal recessive disorder that is one of the leading hereditary causes of infantile mortality in the world. SMA is characterized by the degeneration of moton neurons in the anterior horn of spinal cord, resulting in progressive muscle atrophy and paralysis. SMA is caused by reduced levels of SMN (survival motor neuron) full-length (FL) protein as a result of deletion or mutation of the SMN1 gene. SMN protein can be expressed from two nearly identical genes, SMN1 and SMN2. An important difference between these two genes is

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16

Tein-YuChiu and 邱天佑. "Establishment and application of a real-time and high throughput platform with zebrafish for potential anti-epilepsy compounds screening." Thesis, 2019. http://ndltd.ncl.edu.tw/handle/up9fu3.

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17

Chen, Po-Ting, and 陳柏廷. "Development of a sensitive fluorescence detection system for high-throughput screening compounds which can promote the production of A." Thesis, 2009. http://ndltd.ncl.edu.tw/handle/55937707833165006038.

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碩士<br>國立臺灣大學<br>化學工程學研究所<br>97<br>Amyloid-b (Ab), a physiological peptide, which is produced from amyloid precursor protein (APP) by sequential cleavages, and released into the extracellular spaces. The released Ab undergoes proteolytic degradation by multiple endopeptidases. The imbalance between the production and catabolism of Ab in the brain results in the accumulation of Ab leading to Alzheimer’s disease. Alzheimer’s disease is a neurodegenerative disease, and Ab in Alzheimer’s disease plays a pivotal role in the pathogenesis of the disease. Neprilysin (NEP) has been singled out as the mo

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18

劉俊呈. "Finding The Lead Compounds to Suppress Protein Tyrosine Phosphatase 1B for treating Type II Diabetes by Virtual High Throughput Screening and Pharmacophore Scoring Method." Thesis, 2005. http://ndltd.ncl.edu.tw/handle/36958358785507005380.

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碩士<br>國立清華大學<br>分子醫學研究所<br>93<br>The research on the knock-out studies in mice manifests that the insulin resistance in those mice lacking for PTP1B protein would evidently increases and possesses the certain resistivity against obesity. Consequently, PTP1B is considered as the target for medicine designed to treat for Type II diabetes. With the progress in computational science, it is gradually becoming a trend to utilize the virtual screening method to accelerate the R&D in medication and effectively shorten the time and expense of R & D. In fact, there are not a few successful examples a

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