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Dissertations / Theses on the topic 'HPLC'

Author: Grafiati
Published: 4 June 2021
Last updated: 25 July 2025

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1

Bakirdere, Sezgin. "Speciation Studies Using Hplc-icp-ms And Hplc-es-ms." Phd thesis, METU, 2009. http://etd.lib.metu.edu.tr/upload/3/12611391/index.pdf.

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Knowledge about selenium content of foods containing selenium species is very important in terms of both nutrition and toxicity. Bioavailability of selenium species for human body is different from each other. Hence, speciation of selenium is more important than total selenium determination. In the selenium speciation study, chicken breast samples, selenium supplement tablets and egg samples were analyzed for their selenium contents. In chicken breast study, chickens were randomly categorized into three groups including the control group (25 chickens), inorganic selenium fed group (25 chickens
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2

Forss, Erik. "On-line HPLC." Thesis, Karlstads universitet, Avdelningen för kemiteknik, 2012. http://urn.kb.se/resolve?urn=urn:nbn:se:kau:diva-16166.

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In order to increase the analysis frequency and thereby achieve a better understanding of the kinetics and dynamics of the chemical process without increasing the workload of the already strained analytical laboratory at Cambrex Karlskoga AB, this projects goal was to investigate whether a crude prototype for mobile on-line HPLC-analysis with automatic sampling and dilution could be built based on certain flow-injection analysis techniques. It was possible to achieve dilution with good repeatability even though saturation effects in the filter proved problematic. Separation and dilution of a b
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3

Kadkhodaei-Elyaderani, Manizheh. "HPLC detection of haemoglobinopaties." Thesis, University of Salford, 1996. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.308175.

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4

Narayan, Vicrant S. "HPLC analysis of nucleotides." Thesis, Queensland University of Technology, 2017. https://eprints.qut.edu.au/104440/1/Vicrant_Narayan_Thesis.pdf.

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This project developed a novel hydrophilic interaction chromatography method for the detection and identification of nucleotides. The method was validated by testing biological specimens; adult and neonatal saliva, and red and white blood cell extracts. The project discovered an interesting difference between the adult and neonatal saliva specimens. The neonatal saliva contained 5 additional nucleotides and the nucleotides were present in greater concentrations, when compared to the concentrations in adult saliva. With further optimisation this method may be applied to testing in Pathology ser
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5

Burr, Christina Mary. "Retention prediction in RP-HPLC." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/27346.

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A method of calculating the RP-HPLC retention indices, based on the alkylarylketone scale, has been developed. The retention indices are calculated from the molecular structure of a compound as the sum of the parent contribution, the parent index, the substituent contributions, the substituent indices, and terms to account for the interactions between substituents, the interaction indices.
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6

Ertas, Hasan. "Ageing of silica in HPLC." Thesis, Loughborough University, 1998. https://dspace.lboro.ac.uk/2134/33118.

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This study may be divided into two sections which cover different aspects of the reproducibility problems encountered in HPLC. In the first, the study has involved the separation of basic drugs, on different manufacturer's reversed-phase columns in conjunction with an acid buffered acetonitrile/water gradient. The retention reproducibility of each drug was assessed and compared on the basis of the retention index scale of 1-nitroalkanes. The effect of changing gradient run time on the reproducibility of the retention values of the 1-nitroalkanes was demonstrated on reversed-phases of different
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7

Sonawane, K. B. "Hplc studies of natural products." Thesis(M.Sc.), CSIR-National Chemical Laboratory, Pune, 1999. http://dspace.ncl.res.in:8080/xmlui/handle/20.500.12252/1940.

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8

Mayr, Gerhard. "Bildung und Kompensation von Temperaturgradienten in der schnellen HPLC unter Verwendung von Micropartikel-gepackten HPLC-Säulen." Ulm : Universität Ulm, Fakultät für Naturwissenschaften, 1999. http://www.bsz-bw.de/cgi-bin/xvms.cgi?SWB8303640.

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9

Müller, Sonja. "Analytische Trennungen neuartiger Supramoleküle mittels HPLC." [S.l.] : [s.n.], 2006. http://deposit.ddb.de/cgi-bin/dokserv?idn=980196973.

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10

Thomas, H. D. "Chemiluminescence, a detection method for HPLC." Thesis, University of East Anglia, 1988. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.383774.

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11

Scholtzova, Angela. "Scale up and modelling of HPLC." Thesis, University College London (University of London), 2000. http://ethos.bl.uk/OrderDetails.do?uin=uk.bl.ethos.368109.

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12

Albishri, Hassan Mabrook. "High-temperature HPLC of pharmaceutical compounds." Thesis, Loughborough University, 2007. https://dspace.lboro.ac.uk/2134/36130.

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In this thesis, we established methods that use high-temperature HPLC for the efficient separation of different groups of pharmaceutical compounds. These groups are cephalosporins, non-steroidal anti-inflammatory (NSAID), and diuretic drugs. The effect of changes of the temperature of the column was studied with respect to various chromatographic parameters: retention factors, thermodynamic properties, selectivity, efficiency and peak shape. Three columns (Pathfinder, Xterra RP18, and Selerity's Blaze 200) were examined for the analysis of cephalosporin drugs under high temperature reversed ph
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13

Madahar, Kirpal C. "The determination of ethylenethiourea by HPLC." Thesis, Loughborough University, 1986. https://dspace.lboro.ac.uk/2134/32913.

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The determination of imidazolidine-2-thione (ETU), at residue levels in crops, in ethylenebisdithiocarbamates (EBDC) and on interaction with microorganisms and soils has been investigated using both a direct HPLC method or after derivatisation with phenacyl halides.
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14

Che, Isa Rosmahani. "Analysis of rubber accelerators by HPLC." Thesis, Loughborough University, 2009. https://dspace.lboro.ac.uk/2134/34256.

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The analysis of rubber accelerators particularly zinc dithiocarbamates (ZDTCs) was carried out by high performance liquid chromatography (HPLC) to develop an improved analytical method for the determination of rubber accelerators. Further understanding of their chemical and chromatographic behaviour has been established by investigating a few conventional as well as the latest reported methods, which include the pre-column derivatisation of ZDTCs to cobalt (III) complexes, direct determination by the addition of other protective agent and pre-column derivatisation of ZDTCs to copper (III) comp
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15

Walker, Roderick Bryan. "HPLC analysis and pharmacokinetics of cyclizine." Thesis, Rhodes University, 1995. http://hdl.handle.net/10962/d1003279.

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The investigations detailed in this dissertation have been conducted to address the paucity of pharmacokinetic information, in published literature, pertaining to cyclizine. The areas of investigation have included the selective quantitation of both cyclizine and its demethylated metabolite, norcyclizine in serum and urine, assessment of stability of both compounds in stored biological samples, dosage form analysis, dissolution rate testing of tablets, and bioavailability and pharmacokinetics following administration of an intravenous solution, and tablets to humans. High-performance liquid ch
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16

Mayr, Gerhard [Verfasser]. "Bildung und Kompensation von Temperaturgradienten in der schnellen HPLC unter Verwendung von Micropartikel-gepackten HPLC-Säulen / Gerhard Mayr." Ulm : Universität Ulm. Fakultät für Naturwissenschaften, 1999. http://d-nb.info/1015899285/34.

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17

McCulloch, Melissa. "Development of Quantitative Bioanalytical Methods for the Measurement of Pharmaceutical Compounds via HPLC-UV and HPLC-MS/MS." Cleveland State University / OhioLINK, 2009. http://rave.ohiolink.edu/etdc/view?acc_num=csu1255046678.

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18

Wolfgarten, Eva Maria [Verfasser], and Jörg [Akademischer Betreuer] Heilmann. "HPTLC, HPLC-UV und HPLC-MS Untersuchungen zur Isolierung, zum Fingerprint und zur Quantifizierung von Iridoid- und Phenylethanoidglykosiden in den Blättern von Plantago lanceolata L. / Eva Maria Wolfgarten ; Betreuer: Jörg Heilmann." Regensburg : Universitätsbibliothek Regensburg, 2021. http://d-nb.info/122512140X/34.

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19

Bale, Simon J. "Retention-modification in HPLC using metal ions." Thesis, Loughborough University, 1988. https://dspace.lboro.ac.uk/2134/27578.

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The effects of transition metal ions as components of the mobile phase on the retentions in HPLC of 2-aminophenol and selected α-diketones were studied on both ODS-silica and porous polymer columns. The compounds were used as model compounds in an investigation which set out to derive a detailed understanding of the mechanisms Involved when metal ions are used to selectively modify the retention of compounds capable of interaction. This technique, which has parallels with ion-pair chromatography, provides another method by which the conditions of a separation may be altered and the selectivity
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20

Westlake, James P. "The analysis of basic drugs by HPLC." Thesis, Loughborough University, 1991. https://dspace.lboro.ac.uk/2134/10517.

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Two methods for the high performance liquid chromatographic analysis of basic drugs have been studied. In each case the methods have concentrated on separating drugs of forensic interest, based on specially designed test solutions of analytes selected to represent most of the commonly encountered classes of drug compounds. In the first case, a HPLC method was developed on unmodified silica using an aqueous methanolic eluent of high pH. The buffer was prepared from two organic sulphonic acid amines, 3-(cyclohexylamino)-1- propanesulphonic acid (CAPS) and sodium 3-(cyclohexylamino)-2-hydroxy-1-
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21

Tebrake, Margret G. "Temperature as a parameter in HPLC optimisation." Thesis, Loughborough University, 2003. https://dspace.lboro.ac.uk/2134/33879.

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This study focused on the capabilities of elevated temperature chromatography and its potential applications. The effects of separation temperature on compound retention, selectivity and efficiency were studied. The change in retention with temperature was explored using a number of test compound solutions. A detailed investigation of the importance of system variables like dead volume, mobile phase composition, different stationary phases, and temperature control of column and eluent was performed. The effects of different eluents and different means of temperature control on the separation s
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22

Zahr, Meia. "Separation of Tryptic Digested IgG with HPLC." Thesis, KTH, Skolan för kemi, bioteknologi och hälsa (CBH), 2018. http://urn.kb.se/resolve?urn=urn:nbn:se:kth:diva-233869.

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The antibody immunoglobulin G (IgG) can be tryptically digested into smaller peptides. This study attempted to develop a separation method for those peptides using RP-HPLC with a C18 column at room temperature. Optimizing separation of trypsin cleaved cytochrome C was used as a guideline before analyzing IgG. The optimized analysis of Cytochrome C was performed at wavelength 280nm (UV) and methanol was used as an organic solvent in mobile phase (B). A fast gradient to 100% mobile phase B with low flow rate gave favorable results for cytochrome C. A slow gradient to 100% mobile phase B was suit
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23

Kouřil, Tomáš. "HPLC analýza léčiv." Master's thesis, 2018. http://www.nusl.cz/ntk/nusl-388725.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Tomas Kouril Consultant: Ing. Vladimir Kubicek, CSc. Title of Thesis: HPLC analysis of Drugs The diploma thesis describes selection of the most suitable conditions for determination of a two enantiomers of drugs betaxolol and bisoprolol with a method HPLC. The aim of the thesis was to find a suitable isocratic method for the substances for extraction from plasma. The chromatographic column Daicel Chiralcel ® OD-R 4,6 mm x 250 m was utilized. The best results were achieved with mo
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24

Nováková, Markéta. "HPLC analýza podofylotoxinu." Master's thesis, 2021. http://www.nusl.cz/ntk/nusl-446527.

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Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Pharmaceutical Analysis Candidate: Markéta Nováková Tutor: PharmDr. Pavla Pilařová, Ph.D. Title of Thesis: HPLC Analysis of Podophyllotoxin The diploma thesis is focused on optimalization of HPLC method for the analysis of podophyllotoxin. The method was developed for the analysis of Juniperus virginiana leaves extract. Various stationary phases, mobile phases, temperatures, ultrasonic extraction times were tested. Following conditions were chosen as optimal: 30 minutes ultrasonic extraction ti
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25

Lukšíková, Lada. "HPLC analýza léčiv." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-282942.

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26

Slezáková, Šárka. "HPLC stanovení benzimidazolů." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-337823.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of biophysics and physical chemistry Candidate: Šárka Slezáková Supervisor: Ing. Vladimír Kubíček, CSc. Title of diploma thesis: HPLC Determination of Benzimidazoles In this thesis we have investigated the possibility of establishing benzimidazole with HILIC chromatography using a chromatographic column Ascentis Express HILIC 10.0 cm x 3.0 mm; 2.7 microns. Two groups of benzimidazoles were tested. The first one was focused on albendazole and its metabolites. Experiments with these substances did not produce satisfact
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27

Dohnalová, Monika. "HPLC analýza léčiv." Master's thesis, 2019. http://www.nusl.cz/ntk/nusl-397354.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Monika Dohnalová Supervisor: Ing. Vladimír Kubíček, CSc. Title of Diploma Thesis: HPLC analysis of drugs The diploma thesis deals with the development and optimization of HPLC method for simultaneous determination of selected polyphenolic compounds: apigenin, acteoside and luteolin. During the experiments, the most suitable conditions for separation were sought, various mobile phases and various types of gradient elution were tested. The Zorbax Eclipse XBD C18 column 250 x 4.6 mm
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28

Paličková, Karolína. "HPLC stanovení potenciálních léčiv." Master's thesis, 2017. http://www.nusl.cz/ntk/nusl-368250.

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1 ABSTRACT Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Karolina Palickova Consultant: Ing. Vladimir Kubicek, CSc. Title of Thesis: HPLC Determination of Potencial Drugs The diploma thesis describes selection of the most suitable conditions for HPLC determination of a recently prepared potential bronchodilatans. The aim of the thesis was to find a suitable isocratic method for the HPLC determination of the substance in rat plasma to be used during pharmacokinetic experiments. The chromatographic column Ascentis® Express RP
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Nováková, Lidmila. "HPLC analýza vybraných isoflavonů." Master's thesis, 2020. http://www.nusl.cz/ntk/nusl-435323.

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Charles University Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Author: Lidmila Nováková Supervisor: Ing. Vladimír Kubíček, CSc. Title of thesis: HPLC analysis of selected isoflavones The diploma thesis deals with the development of a method for determination of the concentration of selected isoflavones in samples of biological material by using HPLC. The method is applicable to both glycosylated (daidzeine, genistine and glycitine) and free forms of isoflavones (daidzeine, genisteine). The Ascentis® Express RP column 2,7 µm, 10 cm x 3 mm was used for a
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Koldová, Vendula. "Hodnocení Quetiapinu pomocí HPLC." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-334696.

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Charles University in Praque, Faculty of Pharmacy in Hradci Králové Department: Pharmaceutical Chemistry and Drug Control Candidate: Vendula Koldová Tutor: PharmDr. Pavla Pilařová, Ph.D. Name of Degree Paper: Evaluation of Quetiapine using HPLC In this study was developed a method for separation of quetiapine and its two biologically active metabolites 7-hydroxyquetiapine and norquetiapine. Separation was performed on zirconia reversed-phase column ZirChrom® -PBD (150 x 4.6 mm i.d., 5 µm). The retention behaviour of those three analytes was examined at changing strenght and pH of acetate buffe
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31

Juříčková, Markéta. "HPLC analýza léčiv II." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-282921.

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HPLC ANALYSIS OF DRUGS II. Diploma thesis Markéta Juříčková Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové In diploma thesis the optimal condition for analytical determination of tiaprofenic acid in plasma using solid-phase microextraction (SPME) and high performance liquid chromatography (HPLC) was developed. The final analysis was performed on RP18 analytical column. The mobile phase was composed of a mixture of methanol and phosphate buffer. The flow rate of 0.7 ml/min was used. 2
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32

Blažková, Petra. "HPLC analýza léčiv III." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-282925.

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ANALYTICAL EVALUATION OF ACTIVE SUBSTANCE BY LIQUID CHROMATOGRAPHY II. Diploma thesis Petra Blažková Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové The subject of this diploma thesis is a determination of active substances by liquid chromatography. In particular it deals with an evaluation of phenobarbital in biological matrix. Solid phase microextraction (SPME) and high performance liquid chromatography (HPLC) with UV detector (218 nm) and reversed phase C18 comlumn were used. The m
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33

Štichová, Lucia. "HPLC analýza léčiv IV." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-307831.

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HPLC analysis of drugs IV. Diploma Thesis Lucia Štichová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control, Heyrovského 1203, Hradec Králové In this thesis, conditions were optimized for high-performance liquid chromatography for quantitative evaluation of ibuprofen. It was established solid phase microextraction conditions for which ibuprofen was extracted from whole blood. The fiber was coated with polydimethylsiloxane - divinylbenzene with a thickness of 60 µm. The fiber was immersed in the sample. The blood sample w
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34

Sochová, Veronika. "HPLC analýza léčiv V." Master's thesis, 2013. http://www.nusl.cz/ntk/nusl-322175.

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HPLC analysis of drugs V Diploma thesis Veronika Sochová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control In this diploma thesis was established the methodology for the evaluation of dexamethasone in biological material using solid phase microextraction and HPLC. For the measurements was used extraction fibre polydimethylsiloxane in combination with divinylbenzene. The fiber was used for microextraction of dexamethasone from water samples and plasma samples. Conditions were optimized for SPME evaluation of dexamethason
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35

Krouská, Hana. "HPLC studie chemických reakcí." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-342935.

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In this work hydrolysis of phenylisothiocyanate and subsequent decomposition of diphenylthiourea were studied. RP-HPLC with UV detection was selected for monitoring of these reactions. The new method of isocratic elution was developed and mobile phase composition and flow rate were optimized. Hydrolysis of isothiocyanate was studied as a function of pH and reaction temperature. The subsequent decomposition of diphenylthiourea was carried out at 80 řC depending on the pH.
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36

Žáková, Petra. "Optimalizace HPLC stanovení klotrimazolu." Master's thesis, 2008. http://www.nusl.cz/ntk/nusl-291039.

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High-performance liquid chromatographic technique for the determination of clotrimazole and its degradation products (2-chlorophenyl)-diphenyl methanol and imidazole in the formulation Clotrimazol spray 1 % was developed. The presented thesis was focused to the selection of optimal column, composition of mobile phase, its pH and internal standard for the analysis of pharmaceutical formulation based on topically applied antifungal agent clotrimazole. Seven columns were tested in detail. The tested columns were: Discovery HS F5 (5 μm, 150 x 4.6 mm)Chromolith® Performance, RP-18e (100 x 3 mm)
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Chang, Chih-Chao, and 張智超. "HPLC quantitative analysis of." Thesis, 2008. http://ndltd.ncl.edu.tw/handle/742tcg.

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38

李青. "Assay of Drugs by HPLC." Thesis, 2003. http://ndltd.ncl.edu.tw/handle/41108594823542659370.

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39

Vyroubal, Petr. "HPLC hodnocení vybraných léčiv II." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279050.

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HPLC evaluation of selected drugs II. THESIS Petr Vyroubal Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control In this thesis was validated method for simultaneous HPLC analysis of paracetamol and tramadol in combined tablet. As stationary phase the chromatographic column Discovery HS F5, 5 µm, 150×3 mm I.D. made by Supelco was used. Mobile phase was formed by mixture of acetonitrile : ammonium acetate solution 0.005 mol/l, acidified with acetic acid at pH 3.2 in the ratio 20:80 (v/v). A flow rate was 1.0 ml/min. Acetylsa
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Skryjová, Denisa. "HPLC hodnocení vybraných léčiv I." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279106.

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61 ABSTRACT HPLC evaluation of selected drugs I. THESIS Denisa Skryjová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Control In this thesis were developed the optimum chromatographic conditions for simultaneous HPLC analysis of tramadol and paracetamol in combined tablet. The chromatographic column Discovery HS F5, 5 µm, 150×3 mm I.D. made by Supelco was chosen as the stationary phase. Mobile phase mixture formed acetonitrile : ammonium acetate solution 0.005 mol/l, acidified with acetic acid at pH 3.2 in the ratio 20:80 (
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41

Šestakova, Veronika. "Využití HPLC ve farmaceutické analýze." Master's thesis, 2009. http://www.nusl.cz/ntk/nusl-279512.

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Determination of hexachlorophene in the product SEPTONEX ointment to the Department of Analytical Chemistry performed by HPLC. This method has many advantages over previously used titrate determination. The conditions of analysis are as follows: mobile phase is composed of 85% methanol with the addition of 1% acetic acid, column Purospher Merck RP C18, 5 mm (12.5 cm x 4 mm), flow rate of the mobile phase is 1.5 ml / min, sample injection volume is 20 µl. The aim was to optimize the use of methods, i.e. find the column using the modern trends in HPLC, which would allow obtaining precise, rapid
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Bajcurová, Lucie. "Využití HPLC ve farmaceutické analýze." Master's thesis, 2010. http://www.nusl.cz/ntk/nusl-279529.

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The HPLC method for determination of ketoprofen in therapeutic preparations "PRONTOFLEX" - a 10% skin spray and "Ketonal" - a 5% cream has been developed. This method was based on already developed and validated method for analyzing the preparation "KETOPROFEN" - a 2.5% gel. Both of the methods have been developed in the same department. The chromatographic separation was performed on SUPELCO Discovery C18 column (125 mm x 4.6 mm, 5 µm). The mobile phase consisted of a mixture of acetonitrile, water and a phosphate buffer pH 3.5 (40:58:2, v/v/v). At a mobile phase flow rate of 1.0 ml/min, inje
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43

Soukupová, Petra. "HPLC hodnocení vybraných léčiv IV." Master's thesis, 2011. http://www.nusl.cz/ntk/nusl-296767.

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HPLC evaluation of some drugs IV. THESIS Petra Soukupová Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis This thesis is about looking for the optimal conditions for simultaneous HPLC analysis in combined tablets of perindopril and indapamid with subsequent determination of their content. As the most suitable stacionary phase chromatographic column LiChro CART 250-4 LiChrospher 100, RP18, 5 µm was chosen, and the mobile phase formed by mixture of acetonitrile - ammonium phosphate solution (0,05 mol/l) in the ratio 40:
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44

Kadaňková, Barbora. "HPLC hodnocení vybraných léčiv VI." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-308214.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Barbora Kadaňková Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC hodnocení vybraných léčiv VI. This thesis focuses on assay optimization for simultaneous quantitation of valsartan and hydrochlorothiazide in combined tablets. First, chromatographic conditions were tested and optimized settings were then used for tablet content determination. Good chromatographic separation was achieved using an ET Nucleosil (125x4.6 mm, 120-5, C8) column and a mobile p
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Kašková, Jana. "HPLC hodnocení vybraných léčiv V." Master's thesis, 2012. http://www.nusl.cz/ntk/nusl-308261.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Kašková Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC evaluation of some drugs V. This thesis is about looking for the optimal conditions for simultaneous HPLC analysis in combined tablets of amlodipin and atorvastatin with subsequent determination of their content. As the most suitable stacionary phase was chosen chromatographic column 125x4 mm I. D. contains Nucleosil 120-5 C 18, Macherey-Nagel, and the mobile phase formed by mixture of aceton
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Hynková, Martina. "HPLC hodnocení vybraných léčiv VIII." Master's thesis, 2014. http://www.nusl.cz/ntk/nusl-333273.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Martina Hynková Supervisor: RNDr. Milan Mokrý, CSc. Diploma thesis: HPLC evaluation of selected pharmaceuticals VIII RP-HPLC method for simultaneous analysis of Paracetamol, Ascorbic Acid and Phenylephrine in pharmaceutical formulation (powder for oral solution) was developed. In this formulation, the amount of Paracetamol is sixtimes higher then the amount of Phenylephrine. Macherey-Nagel column NUCLEOSIL C18 (150 mm x 4 mm id, 5 µm particle size) was used as a s
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47

Pleváková, Magdaléna. "Stanovení lipofility léčiv pomocí HPLC." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-339515.

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3 ABSTRACT Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of biophysics and physical chemistry Author: Magdaléna Pleváková Supervisor: Ing. Vladimír Kubíček, CSc. Thesis title: Determination of Lipophilicity of Drugs by HPLC In this thesis a RP-HPLC method for fast and reliable determination of lipophilicity was proposed and tested. Stationary phase was selected by using hydrophobic substraction model. Capacity factors of the chosen substances were initially measured on Zorbax ECLIPSE XDB C18 250x4,6 mm, 5µm column, which exhibits almost identical retention char
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Kopecká, Iva. "Hodnocení zolpidem - tartarátu pomocí HPLC." Master's thesis, 2016. http://www.nusl.cz/ntk/nusl-344175.

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Charles University in Praque, Faculty of Pharmacy in Hradci Králové Department: Pharmaceutical Chemistry and Drug Control Candidate: Iva Kopecká Tutor: PharmDr. Pavla Pilařová, Ph.D. Name of Degree Paper: Evaluation of zolpidem tartrate using HPLC In the diploma thesis, there was optimazed the method of separation of zolpidem tartrate and its impurity A. There was tested the influence of the composition of the mobile phase, molarity of phosphate buffer, its pH and the temperature on the column. The optimal conditions of the separation were determined - methanol:acetonitril: 0,06 mol/l phosphat
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Skopový, Štěpán. "HPLC hodnocení vybraných léčiv XI." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-348613.

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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Štěpán Skopový Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC evaluation of some drugs XI. The main focus of this diploma thesis was to find suitable chromatografic conditions for HPLC analysis of Fenofibrate and Ketorolac. Aproximate chromatographic conditions for analysis of Fenofibrate were suggested based on review of previous research projects concerning HPLC analysis of this drug. As for the stacionary phase, a C18 column (250 x 4.6 mm, 5µm part
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Šušková, Šárka. "HPLC hodnocení vybraných léčiv IX." Master's thesis, 2015. http://www.nusl.cz/ntk/nusl-349311.

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A B S T R A C T C H A R L E S U N I V E R S I T Y I N P R A G U E F A C U L T Y O F P H A R M A C Y I N H R A D E C K R Á L O V É D E P A R T M E N T O F P H A R M A C E U T I C A L C H E M I S T R Y A N D D R U G A N A L Y S I S Name: Šárka Šušková Supervisor: RNDr. Milan Mokrý, CSc. Title: HPLC evaluation of selected drugs IX. This work was focused on optimizing the chromatographic conditions for substances: perindopril erbumine, indapamide, besylatum amlodipine, valsartan and hydrochlorothiazide to develop the same conditions as the analysis in a variety of dosage formulations. The chromato
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