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Journal articles on the topic 'Ideal protein. eng'

Author: Grafiati

Published: 4 June 2021

Last updated: 4 February 2022

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1

Carmona, Guillaume, Lauren Barney, Jared Sewell, et al. "Correcting Rare Blood Disorders Using Coagulation Factors Produced In Vivo By Shielded Living TherapeuticsTM Products." Blood 134, Supplement_1 (2019): 2065. http://dx.doi.org/10.1182/blood-2019-127050.

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Hemophilia A arises from mutations in the F8 gene, affecting ~ 1/5000 males. Treatment options include frequent intravenous factor and subcutaneous non-factor therapies. While these approaches have been widely used, they have significant limitations, such as breakthrough bleeds and joint disease due to suboptimal adherence, non-ideal factor kinetics, inhibitor generation, (Weyand, Blood 2018) as well as risk of thrombotic events and coagulation test interference with newer non-factor therapies. (Peters, Nat Rev Drug Discov 2018) Alternative modalities such as cell therapies with genetically mo

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Ban, Zhan, Peng Yuan, Fubo Yu, Ting Peng, Qixing Zhou, and Xiangang Hu. "Machine learning predicts the functional composition of the protein corona and the cellular recognition of nanoparticles." Proceedings of the National Academy of Sciences 117, no. 19 (2020): 10492–99. http://dx.doi.org/10.1073/pnas.1919755117.

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Protein corona formation is critical for the design of ideal and safe nanoparticles (NPs) for nanomedicine, biosensing, organ targeting, and other applications, but methods to quantitatively predict the formation of the protein corona, especially for functional compositions, remain unavailable. The traditional linear regression model performs poorly for the protein corona, as measured by R2 (less than 0.40). Here, the performance with R2 over 0.75 in the prediction of the protein corona was achieved by integrating a machine learning model and meta-analysis. NPs without modification and surface

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Wang, Yanli, Sihai Zhao, Liang Bai, Jianglin Fan, and Enqi Liu. "Expression Systems and Species Used for Transgenic Animal Bioreactors." BioMed Research International 2013 (2013): 1–9. http://dx.doi.org/10.1155/2013/580463.

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Transgenic animal bioreactors can produce therapeutic proteins with high value for pharmaceutical use. In this paper, we compared different systems capable of producing therapeutic proteins (bacteria, mammalian cells, transgenic plants, and transgenic animals) and found that transgenic animals were potentially ideal bioreactors for the synthesis of pharmaceutical protein complexes. Compared with other transgenic animal expression systems (egg white, blood, urine, seminal plasma, and silkworm cocoon), the mammary glands of transgenic animals have enormous potential. Compared with other mammalia

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March, David, Valentino Bianco, and Giancarlo Franzese. "Protein Unfolding and Aggregation near a Hydrophobic Interface." Polymers 13, no. 1 (2021): 156. http://dx.doi.org/10.3390/polym13010156.

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The behavior of proteins near interfaces is relevant for biological and medical purposes. Previous results in bulk show that, when the protein concentration increases, the proteins unfold and, at higher concentrations, aggregate. Here, we study how the presence of a hydrophobic surface affects this course of events. To this goal, we use a coarse-grained model of proteins and study by simulations their folding and aggregation near an ideal hydrophobic surface in an aqueous environment by changing parameters such as temperature and hydrophobic strength, related, e.g., to ions concentration. We s

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Surówka, K., and D. Żmudziński. "functional properties modification of extruded soy protein concentrate using Neutrase." Czech Journal of Food Sciences 22, No. 5 (2011): 163–74. http://dx.doi.org/10.17221/3420-cjfs.

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Enzymic hydrolysis of extruded soy protein concentrate with Neutrase was used for the preparation new soy protein products with modified functional properties. After the determination of optimum values of pH as 6.8; temperature as 50&deg;C, and water addition as 13.3 kg/kg protein, the response surface methodology with enzyme:substrate ratio and time as independent variables was used to establish optimal conditions of the process. Solubility, water holding capacity (WHC), back extrusion work (BEW) as well as emulsifying (BAI, ESI) and foaming (FO) properties were taken as optimisation crit

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Miller, Benjamin F., Christopher A. Wolff, Fredrick F. Peelor, Patrick D. Shipman, and Karyn L. Hamilton. "Modeling the contribution of individual proteins to mixed skeletal muscle protein synthetic rates over increasing periods of label incorporation." Journal of Applied Physiology 118, no. 6 (2015): 655–61. http://dx.doi.org/10.1152/japplphysiol.00987.2014.

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Advances in stable isotope approaches, primarily the use of deuterium oxide (2H2O), allow for long-term measurements of protein synthesis, as well as the contribution of individual proteins to tissue measured protein synthesis rates. Here, we determined the influence of individual protein synthetic rates, individual protein content, and time of isotopic labeling on the measured synthesis rate of skeletal muscle proteins. To this end, we developed a mathematical model, applied the model to an established data set collected in vivo, and, to experimentally test the impact of different isotopic la

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Suryanty, Melly, and Reswita. "ANALISIS KONSUMSI PANGAN BERBASIS PROTEIN HEWANI DI KABUPATEN LEBONG: PENDEKATAN MODEL AIDS (ALMOST IDEAL DEMAND SYSTEM)." Jurnal AGRISEP 15, no. 1 (2016): 101–10. http://dx.doi.org/10.31186/jagrisep.15.1.101-110.

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This paper analyze the food consumtion base-on animal protein in Lebong. The study estimated a demand model for food base-on animal protein by using Almost Ideal Demand System (AIDS) model. It also estimated demand elasticities for different food items by the models. The result show that the demand model for food-based on animal protein can be explained by AIDS models. The model is consistent with demand theory. The coefficient of determination show range from 12.59 percent to 29.36 percent. However, the homogenity test for restriction parameters have not been explained by the model. The estim

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Pastore, Silvana Marques, Luiz Fernando Teixeira Albino, Paulo Cezar Gomes, et al. "Digestible threonine-to-lysine ideal ratio for laying hens fed with low-protein diets from 24 to 40 weeks of age." Ciência Rural 46, no. 12 (2016): 2229–34. http://dx.doi.org/10.1590/0103-8478cr20150460.

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ABSTRACT: This trial was performed to determine the dietary digestible threonine-to-lysine (dig. Thr-to-Lys) ideal ratio for laying hens fed with low-protein diets from 24 to 40 weeks of age. At 24 weeks of age, two hundred forty Hy Line W-36 laying hens were randomly assigned to five treatments, represented by five dig Thr-to-Lys ratios (60; 67; 74; 81 and 88%), with eight replicates each one with six hens per experimental unit. Digestible Thr-to-Lys did not affect laying hen performance and egg quality, except for digestible Threonine intake, which showed linear increase as dig. Thr-to-Lys r

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Gomes, Ricardo A., Luís M. A. Oliveira, Mariana Silva, et al. "Protein glycation in vivo: functional and structural effects on yeast enolase." Biochemical Journal 416, no. 3 (2008): 317–26. http://dx.doi.org/10.1042/bj20080632.

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Protein glycation is involved in structure and stability changes that impair protein functionality, which is associated with several human diseases, such as diabetes and amyloidotic neuropathies (Alzheimer's disease, Parkinson's disease and Andrade's syndrome). To understand the relationship of protein glycation with protein dysfunction, unfolding and β-fibre formation, numerous studies have been carried out in vitro. All of these previous experiments were conducted in non-physiological or pseudo-physiological conditions that bear little to no resemblance to what may happen in a living cell. I

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Kaczowka, Steven J., Christopher J. Reuter, Lee A. Talarico, and Julie A. Maupin-Furlow. "Recombinant production ofZymomonas mobilispyruvate decarboxylase in the haloarchaeonHaloferax volcanii." Archaea 1, no. 5 (2005): 327–34. http://dx.doi.org/10.1155/2005/325738.

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The unusual physiological properties of archaea (e.g., growth in extreme salt concentration, temperature and pH) make them ideal platforms for metabolic engineering. Towards the ultimate goal of modifying an archaeon to produce bioethanol or other useful products, the pyruvate decarboxylase gene ofZymomonas mobilis(Zmpdc) was expressed inHaloferax volcanii. This gene has been used successfully to channel pyruvate to ethanol in various Gram-negative bacteria, includingEscherichia coli. Although the ionic strength of theH. volcaniicytosol differs over 15-fold from that ofE. coli, gel filtration

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Maribo, Hanne. "104 The Danish Perspective to Remove Medicinal Zinc and Reducing the Use of Antibiotics in Swine Production." Journal of Animal Science 99, Supplement_1 (2021): 103–4. http://dx.doi.org/10.1093/jas/skab054.167.

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Abstract Diarrhoea in weaners has been commonly controlled by adding medicinal zinc (2500 ppm), but by June 2022 this was no longer allowed. In Denmark, antibiotics are accepted for therapeutic use only and usage is registered on pen level and is monitored by Danish authorities. This increases the risk of post-weaning diarrhoea. SEGES has tested several tools, additives e.g. organic acids, diet composition, raw materials e.g. blood plasma. Lowering the protein level in the diet post-weaning is very efficient, but adversely affects productivity. The latest results show on average that a reducti

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Coneglian, Jorge Luis Bernardon, Sergio Luiz Vieira, Josemar Berres, and Dimitri Moreira de Freitas. "Responses of fast and slow growth broilers fed all vegetable diets with variable ideal protein profiles." Revista Brasileira de Zootecnia 39, no. 2 (2010): 327–34. http://dx.doi.org/10.1590/s1516-35982010000200015.

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One thousand eight hundred and ninety male broilers of two strain crosses (fast and slow initial growth) were fed different ideal protein profiles in four-phase feed programs: 1 to 7, 8 to 21, 22 to 34 and 35 to 40 days of age. All vegetable, corn-soybean meal feeds were formulated to maintain the Met+Cys:Lys and Thr:Lys relationships at 75 and 65%, respectively, on true digestible basis. Three ideal protein profiles were used: low, medium and high. From 1 to 21 days of age, half of the birds fed low and high diets were changed to high and low diets, respectively. Birds on the medium diet were

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Faulhaber, Katja, Anton Granzhan, Heiko Ihmels, and Giampietro Viola. "Detection of biomacromolecules with fluorescent light-up probes." Pure and Applied Chemistry 78, no. 12 (2006): 2325–31. http://dx.doi.org/10.1351/pac200678122325.

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The emission properties of selected benzo[b]quinolizinium (acridizinium) derivatives in the presence of double-stranded DNA and proteins are presented. Spectrophotometric studies and linear dichroism (LD) spectroscopic experiments reveal that benzo[b]quinolizinium derivatives bind to DNA, mainly by intercalation. In contrast to the 9-aminobenzo[b]quinolizinium, which exhibits a moderate emission quantum yield in water, the 6-aminobenzo[b]quinolizinium ion as well as N-phenyl-9-aminobenzo[b]quinolizinium derivatives are almost nonfluorescent. The low intrinsic fluorescence quantum yields of the

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Shepley-McTaggart, Ariel, Hao Fan, Marius Sudol, and Ronald N. Harty. "Viruses go modular." Journal of Biological Chemistry 295, no. 14 (2020): 4604–16. http://dx.doi.org/10.1074/jbc.rev119.012414.

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The WW domain is a modular protein structure that recognizes the proline-rich Pro-Pro-x-Tyr (PPxY) motif contained in specific target proteins. The compact modular nature of the WW domain makes it ideal for mediating interactions between proteins in complex networks and signaling pathways of the cell (e.g. the Hippo pathway). As a result, WW domains play key roles in a plethora of both normal and disease processes. Intriguingly, RNA and DNA viruses have evolved strategies to hijack cellular WW domain–containing proteins and thereby exploit the modular functions of these host proteins for vario

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Narayan, Mahesh. "Revisiting the Formation of a Native Disulfide Bond: Consequences for Protein Regeneration and Beyond." Molecules 25, no. 22 (2020): 5337. http://dx.doi.org/10.3390/molecules25225337.

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Oxidative protein folding involves the formation of disulfide bonds and the regeneration of native structure (N) from the fully reduced and unfolded protein (R). Oxidative protein folding studies have provided a wealth of information on underlying physico-chemical reactions by which disulfide-bond-containing proteins acquire their catalytically active form. Initially, we review key events underlying oxidative protein folding using bovine pancreatic ribonuclease A (RNase A), bovine pancreatic trypsin inhibitor (BPTI) and hen-egg white lysozyme (HEWL) as model disulfide bond-containing folders a

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Reilly, Lauren M., Fei He, Heather Mangian, Jolene Hoke, and Gary Davenport. "PSIII-20 Use of legumes and yeast as main protein sources in extruded canine diets." Journal of Animal Science 97, Supplement_3 (2019): 272–73. http://dx.doi.org/10.1093/jas/skz258.553.

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Abstract Plant-based protein sources have gained popularity as consumer demand for grain-free and novel protein sources increase. However, minimal information is available about the effects on digestibility, gastrointestinal tolerance, and fermentative end-products of novel plant-based proteins in dogs. Therefore, the objective of this study was to evaluate legumes and yeast as protein sources in extruded canine diets. Five diets were formulated to be isocaloric and isonitrogenous with either garbanzo beans (GB), green lentils (GL), peanut flour (PF), dried yeast (DY), or poultry byproduct mea

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Hudson, Laura C., Renu Garg, Kenneth L. Bost, and Kenneth J. Piller. "Soybean Seeds: A Practical Host for the Production of Functional Subunit Vaccines." BioMed Research International 2014 (2014): 1–13. http://dx.doi.org/10.1155/2014/340804.

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Soybean seeds possess several inherent qualities that make them an ideal host for the production of biopharmaceuticals when compared with other plant-based and non-plant-based recombinant expression systems (e.g., low cost of production, high protein to biomass ratio, long-term stability of seed proteins under ambient conditions, etc.). To demonstrate the practicality and feasibility of this platform for the production of subunit vaccines, we chose to express and characterize a nontoxic form ofS. aureusenterotoxin B (mSEB) as a model vaccine candidate. We show that soy-mSEB was produced at a h

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Knapp, Joshua, Tsung Cheng Tsai, Joshua Knapp, et al. "PSVI-18 Establishing ideal inclusion rate of fermented soybean meal (FSBM) in nursery rations." Journal of Animal Science 97, Supplement_2 (2019): 210–11. http://dx.doi.org/10.1093/jas/skz122.370.

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Abstract To determine the optimal level of fermented soybean meal (FSBM; Fermex 200, Purina Animal Nutrition, Arden Hills, MN) in nursery diets, a total of 176 weaned pigs (5.96 kg BW) were blocked by initial BW and allotted to 1 of 4 treatments: Control consisted of an enzymatic soybean protein (HP 300, Hamlet Protein, Horsens, Denmark)-poultry byproduct diet or formulated with 5%, 10% and 15% FSBM to achieve FSBM1, FSBM2, and FSBM3 treatments. Pigs remained on the same dietary treatment for phase 1 (d 0–14) and 2 (d 14–29), while a common diet was fed in phase 3 (d 29–40). Individual pig wei

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Makinde, Folasade Maria, K. D. Awoyera, and A. O. Oguntunji. "Effect of Substitution of Chicken Egg with Duck Egg on Biscuit Quality." Sustainable Food Production 5 (February 2019): 38–47. http://dx.doi.org/10.18052/www.scipress.com/sfp.5.38.

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Abstract. Eggs are characterized with other components such antioxidants, folic acid and other B vitamins, and unsaturated fats which might have beneficial effects on heart disease risk that counterbalance the small adverse effect of the eggs’ cholesterol content. A specific study of the effect of chicken egg and/or duck egg in biscuit production has allowed the determination of their respective effects on baking, chemical and sensorial properties. Five sample blends of chicken and duck eggs were made respectively from the following ratios: 0, 10:90, 20:80, 30:70, 40:60 and 50:50%, respectivel

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Sutovsky, Peter, and Won-Hee Song. "Post-fertilisation sperm mitophagy: the tale of Mitochondrial Eve and Steve." Reproduction, Fertility and Development 30, no. 1 (2018): 56. http://dx.doi.org/10.1071/rd17364.

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Preformationist William Harvey’s proclamation of everything live coming from an egg still holds true for mammalian mitochondria and mitochondrial genes. At fertilisation, mitochondria carried into the oocyte cytoplasm by the spermatozoon are sought out and destroyed, leaving only oocyte mitochondria to propagate their mitochondrial (mt) DNA to offspring. This clonal inheritance mode, the ‘mitochondrial Eve’ paradigm, is mediated by oocytes’ resident proteolytic, organelle-targeting mechanisms, including the substrate-specific ubiquitin proteasome system and the autophagic machinery for bulk pr

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Jin, Shikai, Vinicius G. Contessoto, Mingchen Chen, et al. "AWSEM-Suite: a protein structure prediction server based on template-guided, coevolutionary-enhanced optimized folding landscapes." Nucleic Acids Research 48, W1 (2020): W25—W30. http://dx.doi.org/10.1093/nar/gkaa356.

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Abstract The accurate and reliable prediction of the 3D structures of proteins and their assemblies remains difficult even though the number of solved structures soars and prediction techniques improve. In this study, a free and open access web server, AWSEM-Suite, whose goal is to predict monomeric protein tertiary structures from sequence is described. The model underlying the server’s predictions is a coarse-grained protein force field which has its roots in neural network ideas that has been optimized using energy landscape theory. Employing physically motivated potentials and knowledge-ba

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Russnak, R., K. W. Nehrke, and T. Platt. "REF2 encodes an RNA-binding protein directly involved in yeast mRNA 3'-end formation." Molecular and Cellular Biology 15, no. 3 (1995): 1689–97. http://dx.doi.org/10.1128/mcb.15.3.1689.

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The Saccharomyces cerevisiae mutant ref2-1 (REF = RNA end formation) was originally identified by a genetic strategy predicted to detect decreases in the use of a CYC1 poly(A) site interposed within the intron of an ACT1-HIS4 fusion reporter gene. Direct RNA analysis now proves this effect and also demonstrates the trans action of the REF2 gene product on cryptic poly(A) sites located within the coding region of a plasmid-borne ACT1-lacZ gene. Despite impaired growth of ref2 strains, possibly because of a general defect in the efficiency of mRNA 3'-end processing, the steady-state characterist

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Hampp, N., C. Brauchte, and D. Oesterhelt. "Mutated Bacteriortiodopsins: Competitive Materials for Optical Information Processing?" MRS Bulletin 17, no. 11 (1992): 56–60. http://dx.doi.org/10.1557/s0883769400046686.

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In 1971, the first halobacterial retinal protein was discovered and named bacteriorhodopsin. Bacteriorhodopsin (BR) is a protein of 248 amino acids that is integrated into the bacterial membrane. It is a light driven pump, moving protons from the inside to the outside of the cell. The resulting gradient drives the production of ATP (adenosine triphosphate) for the organism. In the 1970s, rapidly growing research activities focused on the biochemical and biophysical properties of BR and resulted in a linearly increasing number of publications per year. The constant level of about 200 publicatio

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Feiz, Leila, Brian S. Beecher, John M. Martin, and Michael J. Giroux. "In Planta Mutagenesis Determines the Functional Regions of the Wheat Puroindoline Proteins." Genetics 183, no. 3 (2009): 853–60. http://dx.doi.org/10.1534/genetics.109.106013.

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In planta analysis of protein function in a crop plant could lead to improvements in understanding protein structure/function relationships as well as selective agronomic or end product quality improvements. The requirements for successful in planta analysis are a high mutation rate, an efficient screening method, and a trait with high heritability. Two ideal targets for functional analysis are the Puroindoline a and Puroindoline b (Pina and Pinb, respectively) genes, which together compose the wheat (Triticum aestivum L.) Ha locus that controls grain texture and many wheat end-use properties.

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Mannige, Ranjan. "The BackMAP Python module: how a simpler Ramachandran number can simplify the life of a protein simulator." PeerJ 6 (October 16, 2018): e5745. http://dx.doi.org/10.7717/peerj.5745.

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Protein backbones occupy diverse conformations, but compact metrics to describe such conformations and transitions between them have been missing. This report re-introduces the Ramachandran number (ℛ) as a residue-level structural metric that could simply the life of anyone contending with large numbers of protein backbone conformations (e.g., ensembles from NMR and trajectories from simulations). Previously, the Ramachandran number (ℛ) was introduced using a complicated closed form, which made the Ramachandran number difficult to implement. This report discusses a much simpler closed form of

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Ohno, Susumu. "Grammatical analysis of DNA sequences provides a rationale for the regulatory control of an entire chromosome." Genetics Research 56, no. 2-3 (1990): 115–20. http://dx.doi.org/10.1017/s0016672300035187.

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SummaryRegardless of their origins, functions, and base compositions, all DNAs are scriptures written following the same grammatical rule. At the level of syllables, two, CG and TA are seldom used, while three, TG, CT and CA are utilized with abundance. Accordingly, at the level of three-letter words, two complementary base trimers, CTG and CAG, invariably enjoy frequent usage. Inasmuch as two of the three frequently used syllables, TG and CA are complementary to each other, while two seldom used syllables, CG and TA, are both palindromes, two complementary strands of DNA are inherently symmet

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Watanabe, Daiki, Shinji Machida, Naoki Matsumoto, Yugo Shibagaki, and Tsutomu Sakurada. "Age Modifies the Association of Dietary Protein Intake with All-Cause Mortality in Patients with Chronic Kidney Disease." Nutrients 10, no. 11 (2018): 1744. http://dx.doi.org/10.3390/nu10111744.

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Whether the effect of a low-protein diet on progression to end-stage renal disease (ESRD) and mortality risk differs between young and elderly adults with chronic kidney disease (CKD) is unclear. We conducted a retrospective CKD cohort study to investigate the association between protein intake and mortality or renal outcomes and whether age affects this association. The cohort comprised 352 patients with stage G3-5 CKD who had been followed up for a median 4.2 years, had undergone educational hospitalization, and for whom baseline protein intake was estimated from 24-h urine samples. We class

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KHATAEE, H. R., and A. R. KHATAEE. "ADVANCES IN F0F1-ATP SYNTHASE BIOLOGICAL PROTEIN NANOMOTOR: FROM MECHANISMS AND STRATEGIES TO POTENTIAL APPLICATIONS." Nano 04, no. 02 (2009): 55–67. http://dx.doi.org/10.1142/s1793292009001587.

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Movement and shape changes are fundamental aspects of all living organisms. This biological motility results from the biological nanomotors, in particular protein nanomotors. Cells contain a variety of protein nanomotors that rotate (e.g., F0F1-ATP synthase or bacterial flagellar motors) or move in a linear fashion (e.g., the kinesin, myosin and dynein motors). F0F1-ATP synthase is one of the ideal nanomotors or energy providing systems for micro/nanomachines because of its small size, smart and perfect structure, and ultra-high energy transfer efficiency. Therefore, in this paper, we have rev

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VIANA, Jeanderson da Silva, Fábio Carneiro STERZELECKI, Juliet Kiyoko SUGAI, and Alex Pires de Oliveira NUÑER. "FEEDING FREQUENCY IN REARING JUVENILES OF SURUVI Steindachneridion scriptum." Boletim do Instituto de Pesca 46, no. 3 (2020): 1–7. http://dx.doi.org/10.20950/1678-2305.2020.46.3.594.

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The present study aimed to determine the ideal feeding frequency of feeding for suruvi juvenile. A study was conducted over 60 days to determine the effects of feeding frequency on growth metrics, body composition, and digestive enzyme activity of juvenile suruvi (initial mean weight: 60.19 ± 10.67 g). The experimental units were 1.0 m3 circular tanks, stocked with 94 fish, connected to a recirculating aquaculture system. The feed was offered during the dark phase of the 12:12 photoperiod with the following treatments in triplicate: FF1 = once a day at 20:00; FF2 = twice a day at 20:00 h and 0

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Nikmatul, Khoiriyah, Anindita Ratya, Hanani Nuhfil, Muhaimin Abdul Wahib, and Muhaimin Abdul Wahib. "THE ANALYSIS DEMAND FOR ANIMAL SOURCE FOOD IN INDONESIA: USING QUADRATIC ALMOST IDEAL DEMAND SYSTEM." Business: Theory and Practice 21, no. 1 (2020): 427–39. http://dx.doi.org/10.3846/btp.2020.10563.

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Indonesia has been experiencing rising animal source food prices during the last five years (decade). In this paper we explore how changes of animal source food prices impact on their demand Indonesia 2016 as expressed in income and price elasticities. Take into account for changes in consumption patterns, as expressed in substitution and complement effects among food items, by including own and cross price elasticities obtained through the parameter estimation of a demand system using QUAIDS. With respect to the total animal food expenditure, chicken meat, beef, fish and milk are luxury goods

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Carter, C., S. Owen, Z. He, et al. "DETERMINATION OF PROTEIN SYNTHESIS IN RAINBOW TROUT, ONCORHYNCHUS MYKISS, USING A STABLE ISOTOPE." Journal of Experimental Biology 189, no. 1 (1994): 279–84. http://dx.doi.org/10.1242/jeb.189.1.279.

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It has been suggested (Houlihan, 1991) that the consumption of 1 g of protein in a variety of species of fish stimulates the synthesis of, approximately, an equal amount of protein. Although synthesis of protein may account for as much as 40 % of the whole-animal oxygen consumption (Lyndon et al. 1992), only about 30 % of the synthesized proteins are retained as growth (Houlihan et al. 1988; Carter et al. 1993a,b). Thus, one focus of attention is the potential advantage gained by fish in allocating a considerable proportion of assimilated energy to protein turnover in contrast to relatively lo

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Walker, Diana L., Dong Wang, Ye Jin, et al. "Skeletor, a Novel Chromosomal Protein That Redistributes during Mitosis Provides Evidence for the Formation of a Spindle Matrix." Journal of Cell Biology 151, no. 7 (2000): 1401–12. http://dx.doi.org/10.1083/jcb.151.7.1401.

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A spindle matrix has been proposed to help organize and stabilize the microtubule spindle during mitosis, though molecular evidence corroborating its existence has been elusive. In Drosophila, we have cloned and characterized a novel nuclear protein, skeletor, that we propose is part of a macromolecular complex forming such a spindle matrix. Skeletor antibody staining shows that skeletor is associated with the chromosomes at interphase, but redistributes into a true fusiform spindle structure at prophase, which precedes microtubule spindle formation. During metaphase, the spindle, defined by s

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Uvebrant, Kristina, Dorthe Da Graça Thrige, Anna Rosén, et al. "Discovery of Selective Small-Molecule CD80 Inhibitors." Journal of Biomolecular Screening 12, no. 4 (2007): 464–72. http://dx.doi.org/10.1177/1087057107300464.

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Protein-protein interactions are widely found in biological systems controlling diverse cellular events. Because these interactions are implicated in many diseases such as autoimmunity and cancer, regulation of protein-protein interactions provides ideal targets for drug intervention. The CD80-CD28 costimulatory pathway plays a critical role in regulation of the immune response and thus constitutes an attractive target for therapeutic manipulation of autoimmune diseases. The objective of this study is to identify small compounds disrupting these pivotal protein-protein interactions. Compounds

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Efstathiou, Antonia, and Despina Smirlis. "Leishmania Protein Kinases: Important Regulators of the Parasite Life Cycle and Molecular Targets for Treating Leishmaniasis." Microorganisms 9, no. 4 (2021): 691. http://dx.doi.org/10.3390/microorganisms9040691.

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Leishmania is a protozoan parasite of the trypanosomatid family, causing a wide range of diseases with different clinical manifestations including cutaneous, mucocutaneous and visceral leishmaniasis. According to WHO, one billion people are at risk of Leishmania infection as they live in endemic areas while there are 12 million infected people worldwide. Annually, 0.9–1.6 million new infections are reported and 20–50 thousand deaths occur due to Leishmania infection. As current chemotherapy for treating leishmaniasis exhibits numerous drawbacks and due to the lack of effective human vaccine, t

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Yang, Yalan, Rong Zhou, Shiyun Zhu, et al. "Systematic Identification and Molecular Characteristics of Long Noncoding RNAs in Pig Tissues." BioMed Research International 2017 (2017): 1–9. http://dx.doi.org/10.1155/2017/6152582.

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Long noncoding RNAs (lncRNAs) are non-protein-coding RNAs that are involved in a variety of biological processes. The pig is an important farm animal and an ideal biomedical model. In this study, we performed a genome-wide scan for lncRNAs in multiple tissue types from pigs. A total of 118 million paired-end 90 nt clean reads were obtained via strand-specific RNA sequencing, 80.4% of which were aligned to the pig reference genome. We developed a stringent bioinformatics pipeline to identify 2,139 high-quality multiexonic lncRNAs. The characteristic analysis revealed that the novel lncRNAs show

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Cooper, Leah, Ronald O. Ball, Paul B. Pencharz, Ryosei Sakai, and Rajavel Elango. "Dispensable Amino Acids, except Glutamine and Proline, Are Ideal Nitrogen Sources for Protein Synthesis in the Presence of Adequate Indispensable Amino Acids in Adult Men." Journal of Nutrition 150, no. 9 (2020): 2398–404. http://dx.doi.org/10.1093/jn/nxaa180.

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ABSTRACT Background Nutritionally, there is a dietary requirement for indispensable amino acids (IAAs) but also a requirement for nitrogen (N) intake for the de novo synthesis of the dispensable amino acids (DAAs). It has been suggested that there might be a dietary requirement for specific DAAs. Objectives Experiment 1 tested whether 9 of the DAAs (Ala, Arg, Asn, Asp, Gln, Glu, Gly, Pro, Ser) are ideal N sources using the indicator amino acid oxidation (IAAO) technique. Experiment 2 examined whether there is a dietary requirement for Glu in adult men. Methods Seven healthy men (aged 20–24 y)

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Yndestad, Arne, Camilla Smith, Thor Ueland, Lars Gullesta, Jan Damås, and Pål Aukrust. "Chemokines in cardiovascular risk prediction." Thrombosis and Haemostasis 97, no. 05 (2007): 748–54. http://dx.doi.org/10.1160/th07-01-0029.

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SummaryIn consideration of the important role of inflammation in plaque progression and stability, recent work has focused on whether plasma markers of inflammation can non-invasively diagnose and predict coronary artery disease (CAD) and other forms of atherosclerotic disorders. Although several studies support an important pathogenic role of chemokines in atherogenesis and plaque destabilization, potentially representing attractive therapeutic targets in atherosclerotic disorders,this does not necessarily mean that chemokines are suitable parameters for risk prediction. In fact, the ability

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Pomar, Candido. "46 How far we could go reducing crude protein with the use of supplemental amino acids." Journal of Animal Science 97, Supplement_2 (2019): 22–23. http://dx.doi.org/10.1093/jas/skz122.042.

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Abstract Feeding growing pigs with diets providing the required amount of essential and non-essential amino acids (AA) reduces energy expenditure and minimizes N excretion. Low protein diets can be obtained by supplementing feeds with crystalline AA. Numerous experiments have evaluated the ideal dietary AA concentration at different growth stages, but reducing dietary protein with the use of supplemental AA is limited by the inaccuracy of the principles used to estimate AA requirements. One of these principles states that growing animals need AA for maintenance and growth. Maintenance requirem

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Porter, Andrew C., Francis Stewart та Ke Xu. "Gene Correction in Human Cells Is Promoted by the Bacteriophage Protein Redβ." Blood 106, № 11 (2005): 3047. http://dx.doi.org/10.1182/blood.v106.11.3047.3047.

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Abstract Correction of a disease gene mutation by homologous recombination (HR) with a transfected DNA repair template represents an ideal form of gene therapy for many inherited hematological disorders. Therapeutic gene correction via HR in hematopoietic stem cells is unlikely to succeed, however, without major improvements in its efficiency. One promising approach is to use an engineered zinc finger endonuclease to specifically cleave the target gene and so promote HR between a dsDNA template and its chromosomal target (Urnov et al (2005) Nature 435:646-51). We are exploring an alternative a

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Calogero, Raffaele A., Stefania Lanzardo, Laura Conti, and Federica Cavallo. "A pipeline to detect antibody-targetable cancer stem cell proteins." Journal of Clinical Oncology 30, no. 15_suppl (2012): e13527-e13527. http://dx.doi.org/10.1200/jco.2012.30.15_suppl.e13527.

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e13527 Background: Monoclonal antibody represents an ideal tool to develop highly specific drugs. However, the efficacy of antibody-based drugs is strongly dependent by the effect that the protein targeted will have on the disease cell. Particularly interesting, as target for antibody therapy, are oncoantigens (OAs), i.e., surface tumor antigen that supports tumor growth. Methods: We have developed a two steps pipeline that allows identifying moAbs directed against e.g., cancer stem cells (CSC) OAs. First step: we compare transcription profiles, derived by tumor cell line grown as epithelial m

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Castilha, Leandro Dalcin, Paulo Cesar Pozza, Ricardo Vianna Nunes, Doglas Batista Lazzeri, Marcelo Luiz Somensi, and Magali Soares dos Santos Pozza. "Levels of digestible isoleucine on performance, carcass traits and organs weight of gilts (15 - 30 KG)." Ciência e Agrotecnologia 36, no. 4 (2012): 446–53. http://dx.doi.org/10.1590/s1413-70542012000400009.

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The ideal protein concept for pigs has allowed reducing levels of crude protein in the diet, since synthetic amino acids are included because the branched chain amino acids may be limiting. In order to determine the digestible isoleucine requirement for gilts from 15 to 30 kg, a performance assay was accomplished, using 40 crossbreed gilts of high genetic potential, averaging 15.00 ± 0.52 kg of body weight, alloted in a randomized blocks design, consisting of five treatments (0.45, 0.52, 0.59, 0.66, 0.73% of digestible isoleucine), four replicates and two animals per experimental unit. Perform

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Dunne, Matthew, Mario Hupfeld, Jochen Klumpp, and Martin Loessner. "Molecular Basis of Bacterial Host Interactions by Gram-Positive Targeting Bacteriophages." Viruses 10, no. 8 (2018): 397. http://dx.doi.org/10.3390/v10080397.

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The inherent ability of bacteriophages (phages) to infect specific bacterial hosts makes them ideal candidates to develop into antimicrobial agents for pathogen-specific remediation in food processing, biotechnology, and medicine (e.g., phage therapy). Conversely, phage contaminations of fermentation processes are a major concern to dairy and bioprocessing industries. The first stage of any successful phage infection is adsorption to a bacterial host cell, mediated by receptor-binding proteins (RBPs). As the first point of contact, the binding specificity of phage RBPs is the primary determina

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Kaminaka, Shoji, and Teizo Kitagawa. "A Novel Idea for Practical UV Resonance Raman Measurement with a Double Monochromator and its Application to Protein Structural Studies." Applied Spectroscopy 46, no. 12 (1992): 1804–8. http://dx.doi.org/10.1366/0003702924123485.

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A practical system for UV resonance Raman (RR) measurements based on the combined use of the first-/second-order dispersions of two gratings in an ordinary double monochromator is proposed. This system rejects visible stray light completely and gives four times larger throughput than the combination of the normal second-order dispersion of two gratings and a visible-cut filter. Newly designed f/1.1 Cassegrainian mirror optics and a sensitive spinning cell using an ESR sample tube are combined with this spectrometer and applied to measurements of UV RR spectra of hen egg white lysozyme. The con

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Swann, Karl, Alex McDougall, and Michael Whitaker. "Calcium signalling at fertilization." Journal of the Marine Biological Association of the United Kingdom 74, no. 1 (1994): 3–16. http://dx.doi.org/10.1017/s002531540003561x.

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It is generally agreed that fertilization in deuterostomes is accompanied by a large intracellular calcium wave that triggers the onset of development, but we still do not know exactly how the calcium wave is generated. The question has two parts: how does interaction of sperm and egg initiate the calcium wave, and how does the calcium wave spread across the cell? Two provisional answers are available to the first part of the question, one involving receptor-G-protein interactions of the sort that mediate trans-membrane signal transduction in somatic cells, the other injection of an activating

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Erdbrügger, Uta, and Thu H. Le. "Extracellular vesicles as a novel diagnostic and research tool for patients with HTN and kidney disease." American Journal of Physiology-Renal Physiology 317, no. 3 (2019): F641—F647. http://dx.doi.org/10.1152/ajprenal.00071.2019.

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Hypertension (HTN) affects one in three adults in the United States and is a major risk factor for cardiovascular disease and kidney failure. There is emerging evidence that more intense blood pressure lowering reduces mortality in patients with kidney disease who are at risk of cardiovascular disease and progression to end-stage renal disease. However, the ideal blood pressure threshold for patients with kidney disease remains a question of debate. Novel tools to more precisely diagnose HTN, tailor treatment, and predict the risk of end-organ damage such as kidney disease are needed. Analysis

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Litvack, Michael L., and Nades Palaniyar. "Review: Soluble innate immune pattern-recognition proteins for clearing dying cells and cellular components: implications on exacerbating or resolving inflammation." Innate Immunity 16, no. 3 (2010): 191–200. http://dx.doi.org/10.1177/1753425910369271.

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Soluble innate immune pattern-recognition proteins (sPRPs) identify non-self or altered-self molecular patterns. Dying cells often display altered-self arrays of molecules on their surfaces. Hence, sPRPs are ideal for recognizing these cells and their components. Dying cell surfaces often contain, or allow the access to different lipids, intracellular glycoproteins and nucleic acids such as DNA at different stages of cell death. These are considered as ‘eat me’ signals that replace the native ‘don’t eat me’ signals such as CD31, CD47 present on the live cells. A programmed cell death process s

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Liebert, Frank. "Invited review: Further progress is needed in procedures for the biological evaluation of dietary protein quality in pig and poultry feeds." Archives Animal Breeding 60, no. 3 (2017): 259–70. http://dx.doi.org/10.5194/aab-60-259-2017.

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Abstract. Recently, biological procedures for feed protein evaluation in pig and poultry diets have been based on the amino acid composition of feed ingredients considering the animal's losses during processes of digestion or total protein utilization in a different manner. Such a development towards individual amino acids (AAs) was inevitable according to the disadvantage of traditional protein quality measures, like biological value (BV) or net protein utilization (NPU), to be non-additive in complex animal diets. In consequence, such measures are generally not suitable for predicting the fi

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Pencharz, P. B., R. Clarke, E. H. Archibald, and N. Vaisman. "The effect of a weight-reducing diet on the nitrogen metabolism of obese adolescents." Canadian Journal of Physiology and Pharmacology 66, no. 11 (1988): 1469–74. http://dx.doi.org/10.1139/y88-240.

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Rates of whole body amino nitrogen flux were measured in 16 obese adolescents undergoing weight reduction with a high protein low energy diet. The subjects received approximately 2.5 g of animal protein per day per kilogram ideal body weight and maintained nitrogen balance throughout the 18 days on the diet. Flux rates were calculated separately from the cumulative excretion of 15N in urinary ammonia and urea following the administration of a single dose of [15N]glycine. The pattern of 15N label appearance in urinary ammonia and urea nitrogen was followed for 72 h after the administration of [

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Wolthuis, Esther K., Goda Choi, Mark C. Dessing, et al. "Mechanical Ventilation with Lower Tidal Volumes and Positive End-expiratory Pressure Prevents Pulmonary Inflammation in Patients without Preexisting Lung Injury." Anesthesiology 108, no. 1 (2008): 46–54. http://dx.doi.org/10.1097/01.anes.0000296068.80921.10.

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Background Mechanical ventilation with high tidal volumes aggravates lung injury in patients with acute lung injury or acute respiratory distress syndrome. The authors sought to determine the effects of short-term mechanical ventilation on local inflammatory responses in patients without preexisting lung injury. Methods Patients scheduled to undergo an elective surgical procedure (lasting &gt; or = 5 h) were randomly assigned to mechanical ventilation with either higher tidal volumes of 12 ml/kg ideal body weight and no positive end-expiratory pressure (PEEP) or lower tidal volumes of 6 ml

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NISTOR, Andreea Cătălina, Lucia Iuliana NISTOR (COTFAS), and Marius Giorgi USTUROI. "A Review of Fatty Acid and Amino Acids Profile from Pasteurized Egg Liquids Produced in Romania." Bulletin of University of Agricultural Sciences and Veterinary Medicine Cluj-Napoca. Food Science and Technology 75, no. 2 (2018): 143. http://dx.doi.org/10.15835/buasvmcn-fst:2017.0034.

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Egg is a rich source of nutrients, such as high-quality protein (containing the ideal proportion of amino acids necessary for human body development) and a rich variety of vitamins and minerals. Liquid egg products have grown to a large extent in the food industry and beyond, which is an important reason to know their quality. For the analysis was used fresh pasteurized yolk and white wrapped bag in box. The fatty acids were determined by gas chromatographic method and amino acids by high performance liquid chromatography method. The results indicated that 34% of total fatty acids analyzed are

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