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1

Bruton, Rachel Kathlyn. An immunological and biochemical investigation of some cental metabotropic glutamate receptors (mGluRs). Birmingham: University of Birmingham, 1996.

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2

Oughterson, Susan Michelle. Fish calcitonins and the ultimobranchial gland: A histological, immunological and physiological investigation. Salford: University of Salford, 1992.

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3

Watson, J. Graham. Handbook of immunological investigations in children. London: Wright, 1990.

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4

Nichols, Eve K. Expanding access to investigational therapies for HIV infection and AIDS: March 12-13, 1990, conference summary. Washington, D.C: National Academy Press, 1991.

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5

Office, General Accounting. Gulf war illnesses: Procedural and reporting improvements are needed in DOD's investigative processes : report to the Honorable Lane Evans, Ranking Minority Member, Committee on Veterans Affairs, House of Representatives. Washington, D.C. (P.O. Box 37050, Washington, D.C. 20013): The Office, 1999.

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6

Sheila, Davey, World Health Organization, UNICEF, and World Bank, eds. State of the world's vaccines and immunization. 3rd ed. Geneva: World Health Organization, 2009.

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7

Committee on the Use of Animals in Research (U.S.), National Academy of Sciences (U.S.), and Institute of Medicine (U.S.), eds. Science, medicine, and animals. Washington, D.C: National Academy Press, 1991.

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8

Berden, Jo H. M., and Jack F. M. Wetzels. Immunological investigation of the patient with renal disease. Edited by Christopher G. Winearls. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0017.

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Laboratory techniques (electrophoresis, indirect immunofluorescence, ELISA, and immunoblotting) required for immunological investigation of the patient with renal disease are described. Renal disease-related aspects of immunoglobulins (immunoglobulin A, paraproteins, cryoglobulins), complement, antinuclear antibodies, anti-C1q antibodies, antineutrophil cytoplasmic antibodies, anti-glomerular basement membrane antibodies, antipodocyte antibodies, antiphospholipid antibodies, and antimicrobial responses (streptococci, hepatitis C, hepatitis B) are reviewed. Laboratory assays which evaluate the immune response, in particular the identification of (auto)-antibodies are valuable tools in establishing a diagnosis and/or monitoring of the activity of the disease. Guidelines are given for immunological studies in patients with specific renal syndromes including nephrotic syndrome, rapidly progressive glomerulonephritis, systemic lupus erythematosus, and thrombotic microangiopathy.
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9

Nithi, Kannan, and Sarosh Irani. Investigation in neurological disease. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0221.

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This chapter provides a brief overview of the more commonly available neurophysiology and neuroradiology techniques, guidance on how to perform a lumbar puncture, and a summary of biochemical, immunological, and genetic tests relevant to neurological disorders.
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10

Handbook of Immunological Investigations in Children. Elsevier, 1990. http://dx.doi.org/10.1016/c2013-0-06488-2.

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11

Condon, Marie, Philippa Dodd, and Liz Lightstone. The patient with systemic lupus erythematosus. Edited by Giuseppe Remuzzi. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0162.

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AbstractSystemic lupus erythematosus (SLE) is a chronic, relapsing, inflammatory, often febrile multisystemic disorder, characterized by involvement of the skin, joints, visceral organs, and serosal membranes. Symptoms and manifestations vary widely over an unpredictable relapsing and remitting course.The presentation of SLE can range from mild forms to severe disease requiring hospitalization. Most commonly it manifests as a combination of constitutional symptoms, particularly fatigue and fever, with cutaneous, musculoskeletal, mild haematological, and serological involvement; however, when renal, haematological or central nervous system disease predominate it can be more severe, even life-threatening. There is a tendency for the disease pattern present at the time of onset to prevail during subsequent exacerbations.Investigating SLE depends to an extent on the presentation of the individual. However a number of haematological, biochemical and immunological investigations provide useful diagnostic information, either for the disease itself or in context of organ system involvement, and should be performed routinely.The presence of lupus nephritis should be considered in any lupus patient with impaired kidney function, proteinuria, hypertension, or an active urine sediment; the gold standard investigation in this context is a kidney biopsy. Glomerular immune complex deposition is the hallmark of lupus nephritis and underpins the International society of Nephrology/Renal Pathology Society classification of lupus nephritis.The diagnosis of SLE is based upon the presence of clinical and/or laboratory features and immunological markers that meet the various published diagnostic criteria. In 2012, lupus nephritis identified on kidney biopsy became an independent diagnostic criterion.This chapter goes through the clinical manifestations, investigations (including a detailed look at the kidney biopsy) and a review of the latest published diagnostic criteria.
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12

Turner, Helen E., Richard Eastell, and Ashley Grossman, eds. Endocrinology (Oxford Desk Reference). Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199672837.001.0001.

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Oxford Desk Reference: Endocrinology provides an overview of the principles of endocrinology, a detailed pathophysiology of disorders of the endocrine system, and practical advice on the clinical presentation of the spectrum of endocrine disease. Written by over 100 international experts, it discusses the diagnosis, management, and relevant genetic and immunological aspects of endocrine disorders. Whilst discussion of common endocrine conditions is comprehensive, it also includes rare syndromes with useful guidance on screening and follow-up. Providing clinical advice to endocrinologists, general physicians, and specialist nurses, it also includes background to biochemical, immunological, genetic, and epidemiological aspects of endocrinology. It is extensively cross-referenced, with suggestions for further reading, includes links to recent international guidelines, and is illustrated throughout with diagrams, tables, and radiological images. There is a quick reference section which covers algorithms for investigation and management of commonly encountered clinical scenarios for use in the clinic. There is an outpatient resource for explanation of endocrine conditions to patients using diagrams of common conditions while in the clinic, in addition to patient support groups and advice, and discussion on legal aspects of medicine and driving regulations. This should be a very useful resource for all involved in the assessment and management of any patient with any form of a possible endocrine disorder.
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13

Ferini-Strambi, Luigi, and Sara Marelli. Sleep disorders in multiple sclerosis. Edited by Sudhansu Chokroverty, Luigi Ferini-Strambi, and Christopher Kennard. Oxford University Press, 2017. http://dx.doi.org/10.1093/med/9780199682003.003.0033.

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Though often unrecognized, sleep disorders in MS are seen at higher frequency than the general population, and they may contribute to pain, fatigue and depression—symptoms commonly observed in MS patients. Since several immunological factors in serum have been implicated in the development of sleep disorders, and MS is proven to be characterized by immune abnormalities, the notion that MS and sleep disorders share a similar background seems reasonable. Investigation of sleep disorders in MS is important, especially considering that the treatment of sleep disturbance may contribute to a reduction in debilitating symptoms, such as fatigue. Thus, an increased clinical awareness and appropriate treatment of sleep disorders in the MS population may significantly improve the overall quality of life in these patients.
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14

Lalvani, Ajit, and Katrina Pollock. Defences against infection. Edited by Patrick Davey and David Sprigings. Oxford University Press, 2018. http://dx.doi.org/10.1093/med/9780199568741.003.0303.

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The immune system is classified into a series of component parts, each specialized to defend the host against infection. Cells of the innate immune system are distributed throughout the body, in the tissues, and in the circulation, to defend against the first signs of danger, combining the acute inflammatory response with the ability to kill and remove invading pathogens. Monocytes, macrophages, and neutrophils phagocytose and kill exogenous and endogenous targets, using both oxygen-dependent and oxygen-independent mechanisms. The adaptive immune system creates a structurally specific and prolonged response, mediated by lymphocytes to clear infection and generate immunological memory. In this chapter, the functions of the innate and adaptive immune system are reviewed, together with the clinical features and investigation of acquired and inherited immune deficiencies.
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15

Isaacs, Anthony, and David Isenberg. Laboratory tests and investigations. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780198739180.003.0005.

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In this chapter an overview is provided of the investigations used in patients with systemic lupus erythematosus (SLE); these establish the abnormalities that can be found in each organ/system. Lupus is a very heterogeneous condition, affecting virtually every organ/system. In consequence, numerous investigations and tests are used to help make the diagnosis and define the extent of the organ/system involvement. The chapter is divided into investigations of the effects of SLE on the following systems: haematological, immunological, biochemical, renal, cardiovascular, pulmonary, gastroenterological, neurological, dermatological, and musculoskeletal. These targeted organ/system-based investigations can then be used to assess ongoing disease activity or the consequence of damage caused by previously active disease.
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16

Jin, Tianru. Investigations of the immunological determinants involved in the slide agglutination test for "Campylobactoer jejuni". 1988.

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17

Jolly, Elaine, Andrew Fry, and Afzal Chaudhry, eds. Allergy. Oxford University Press, 2016. http://dx.doi.org/10.1093/med/9780199230457.003.0002.

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Chapter 2 covers the basic science and clinical topics relating to allergy which trainees are required to learn as part of their basic training and demonstrate in the MRCP. It covers basic science, atopy, food, drug, latex, and venom allergy, urticaria and angio-oedema, anaphylaxis, approach to the immunosuppressed individual, immunodeficiency, immunology investigations, and immunological therapies.
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18

(Editor), Helen Tryphonas, Michel Fournier (Editor), Barry R. Blakley (Editor), Pauline Brousseau (Editor), and Judit Smits (Editor), eds. Investigative Immunotoxicology. CRC, 2005.

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19

Barratt, Jonathan, Peter Topham, Sue Carr, Mustafa Arici, and Simon Liew, eds. Oxford Desk Reference Nephrology. 2nd ed. Oxford University Press, 2021. http://dx.doi.org/10.1093/med/9780198777182.001.0001.

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Written for the busy nephrologist and internist who need easy to access information on the diagnosis, investigation, and treatment of patients with kidney disease, the Oxford Desk Reference Nephrology is presented in a way that is not only easy to read and digest but also is detailed enough to allow an in depth understanding of the complex mix of metabolic, immunological, and genetic causes of both acute and chronic kidney disease. The kidneys are rarely affected by disease in isolation; the book comprehensively covers the multisystem disorders that require a multidisciplinary approach, including the cardiological, rheumatological, haematological, infectious, oncological, and urological aspects of kidney disease. In parallel, it extensively describes the myriad multisystem complications of progressive chronic kidney disease with practical advice on how these should be investigated and managed. The importance of understanding the evolution of kidney disease in children and young adults is covered, as in many parts of the world there is no distinction between adult and paediatric nephrology. Therefore, it is important that nephrologists have a sound grasp of both paediatric and adult kidney diseases. The number of patients with advanced kidney disease treated with a kidney transplant or receiving dialysis is increasing in all parts of the world. All nephrologists will manage patients on dialysis or who have a kidney transplant and all internists will encounter these patients. Thus, it is imperative that they have an understanding of these treatments and the commonly encountered medical problems such patients experience.
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20

Bucala, Richard, and Ruth R. Montgomery. Experimental Approaches for the Investigation of Innate Immunity: The Human Innate Immunity Handbook. World Scientific Publishing Co Pte Ltd, 2016.

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21

Woywodt, Alexander, and Diana Chiu. The glomerulus and the concept of glomerulonephritis. Edited by Neil Turner. Oxford University Press, 2015. http://dx.doi.org/10.1093/med/9780199592548.003.0042.

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The key features of glomerular diseases—haematuria, proteinuria, loss of glomerular filtration rate, and hypertension—were recognized in the nineteenth century, and some earlier, but Richard Bright is usually given credit for synthesizing the concepts of renal disease, and glomerulonephritis came under the heading of Bright’s disease for almost a century. Separation into different types was based on first clinical syndromes, but in the early twentieth century, pathological description was improving and with the introduction of percutaneous renal biopsies in the 1950s, in the 1960s histopathological definitions assumed the ascendancy. A unifying classification of glomerular disease remains work in progress. Current classifications are pathologically based but increasingly include the results of other investigations (including genotype and a variety of immunological and other tests). This chapter follows this pragmatic, hybrid approach, categorizing glomerular disease by pattern on renal biopsy except where aetiological factors are clearly identified (e.g. HIV nephropathy), or associated multisystem disease is defined (e.g. lupus nephritis), or the immunopathogenesis is well characterized (e.g. antiglomerular basement membrane disease).
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22

Mukherjee, Asoke, and Ronald Lieberman. Principles of Drug Development in Transplantation and Autoimmunity (Medical Intelligence Unit). R G Landes Co, 1995.

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23

1944-, Lieberman Ronald, and Mukherjee Asoke, eds. Principles of drug development in transplantation and autoimmunity. New York: Chapman & Hall, 1996.

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24

Expanding Access to Investigational Therapies for HIV Infection and AIDS. National Academies Press, 1991.

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25

R, Stratton Kathleen, Wilson Christopher B. 1946-, McCormick Marie C, and Institute of Medicine (U.S.). Immunization Safety Review Committee., eds. Immunization safety review: Multiple immunizations and immune dysfunction. Washington, D.C: National Academy Press, 2002.

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26

Immunization Safety Review: Multiple Immunizations and Immune Dysfunction (The Compass series). National Academies Press, 2002.

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27

M, Hardy Leslie, and Institute of Medicine (U.S.). Committee on Prenatal and Newborn Screening for HIV Infection., eds. HIV screening of pregnant women and newborns. Washington, D.C: National Academy Press, 1991.

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28

HIV Screening of Pregnant Women And Newborns. Natl Academy Pr, 1990.

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