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Journal articles on the topic 'Immunomodulatory and anti-inflammatory activity'

Author: Grafiati

Published: 4 June 2025

Last updated: 1 August 2025

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1

Ghoisya Zahiro Shofa. "Literature Review: Potensi Daun Sembung (Blumea balsamifera) sebagai Imunomodulator pada Hewan Percobaan." VitaMedica : Jurnal Rumpun Kesehatan Umum 3, no. 3 (2025): 122–28. https://doi.org/10.62027/vitamedica.v3i3.400.

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One chemical substance that can enhance the function and activity of the immune system is an immunomodulator. Immunomodulators can be found in various plants, including sembung leaves (Blumea balsamifera). This study aims to evaluate the potential of sembung leaf extract as an immunomodulator in experimental animals using a systematic literature review method. Articles were collected based on the keywords “immunomodulatory,” “sembung leaves,” and “body immunity” from the Google Scholar, Science Direct, and PubMed databases. The results of animal studies indicate that the administration of etha

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Smit, H. F., B. H. Kroes, A. J. J. van den Berg, et al. "Immunomodulatory and anti-inflammatory activity of Picrorhiza scrophulariiflora." Journal of Ethnopharmacology 73, no. 1-2 (2000): 101–9. http://dx.doi.org/10.1016/s0378-8741(00)00268-3.

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Nerkar, Amit G., and Rushikesh P. Nagarkar. "Ethnopharmacological review of anticancer activity of vinca and turmeric." Current Trends in Pharmacy and Pharmaceutical Chemistry 5, no. 3 (2023): 88–93. http://dx.doi.org/10.18231/j.ctppc.2023.020.

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Natural products with immunomodulatory effects are widely used in the treatment of many diseases, including autoimmune diseases, as well as cancer and inflammatory diseases. They have attracted great interest as therapeutic agents in recent decades because they offer inexpensive and less toxic products than synthetic chemotherapy agents. Immunomodulators are substances that have the ability to improve or suppress the host's defense response, which can be used for prevention and in combination with other treatments. The anticancer effects of these immunomodulators result from their anti-inflamm

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Zimecki, Michał, Jolanta Artym, Wojciech Cisowski, Irena Mażol, Maciej Włodarczyk, and Michał Glenśk. "Immunomodulatory and Anti-Inflammatory Activity of Selected Osthole Derivatives." Zeitschrift für Naturforschung C 64, no. 5-6 (2009): 361–68. http://dx.doi.org/10.1515/znc-2009-5-610.

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IFrom osthole [7-methoxy-8-(3-methyl-but-2-enyl)-chromen-2-one] (), obtained by selective extraction of Peucedanum ostruthium (L.) W. Koch roots, ostholic acid (II) was synthetized as a result of its oxidation with chromium trioxide. From ostholic acid, through its chloride, four amides were obtained: the morpholide 1, the p-chloro-benzylamide 2, the piperidine 3 and the N-methyl-piperazide 4. Except for 1, other compounds have not been described before. The amides 1 - 4 and their precursor osthole (I) were tested for their potential activities in selected immunological assays. The compounds s

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Tuominen, M., L. Bohlin, and W. Rolfson. "Anti-Inflammatory and Immunomodulatory Activity of the FernPolypodium decumanum." Planta Medica 57, S 2 (1991): A2—A3. http://dx.doi.org/10.1055/s-2006-960239.

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Bulska, Magdalena, and Daria Orszulak-Michalak. "Immunomodulatory and anti-inflammatory properties of macrolides." Current Issues in Pharmacy and Medical Sciences 27, no. 1 (2014): 61–64. http://dx.doi.org/10.2478/cipms-2014-0015.

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Abstract Macrolides are a group of antibiotics whose activity is ascribable to the presence of the macrolide ring, to which one or more deoxy sugars may be attached. Two properties are inherent in this group of antibiotics, the immunomodulatory and the anti-inflammatory actions, ensuring great efficacy in a wide spectrum of infections. Macrolides demonstrate several immunomodulatory activities both in vitro and in vivo. They can down-regulate prolonged inflammation, increase mucus clearance, prevent the formation of bacterial biofilm and either enhance or reduce activation of the immune system

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Orjon Rroji and Admir Jançe. "Medicinal herbs in Albania: A treasure that we should preserve." GSC Biological and Pharmaceutical Sciences 32, no. 1 (2025): 215–21. https://doi.org/10.30574/gscbps.2025.32.1.0280.

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The aim of the present review is to highlight the significance and therapeutic benefits of medicinal herbs used for medical purposes. A comprehensive literature search was conducted using major scientific databases, including Scopus, PubMed, ScienceDirect, and Google Scholar, to identify relevant published studies. The therapeutics effects of Salvia officinalis, Papaver rhoeas, Hypericum perforatum, Oleum olivarum, Spartium junceum, honey (Mel) and Propolis have been described in this review. We summarized the therapeutic effects of each medicinal herb described and we could say that Salvia of

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Machado, Joleen Lopes, Anne Karine Martins Assunção, Mayara Cristina Pinto da Silva, et al. "Brazilian Green Propolis: Anti-Inflammatory Property by an Immunomodulatory Activity." Evidence-Based Complementary and Alternative Medicine 2012 (2012): 1–10. http://dx.doi.org/10.1155/2012/157652.

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The immunomodulatory and anti-inflammatory activities of green propolis extracts fromApis melliferawere investigated using acute and chronic inflammation models. Swiss mice were anesthetized and a cotton pellet granuloma was implanted in subcutaneous tissue. Then the mice were divided into six groups and received apyrogenic water or different propolis extracts by oral route (5 mg/kg). According to the treatment the groups were designated as E1A, E1B, E10, E11, and E12. The control group received apyrogenic water. The treatment was performed by six days when the mice were killed. The blood and

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Bozrova, S. V., V. A. Levitsky, S. A. Nedospasov, and M. S. Drutskaya. "Imiquimod: the biochemical mechanisms of immunomodulatory and anti-inflammatory activity." Biomeditsinskaya Khimiya 59, no. 3 (2013): 249–66. http://dx.doi.org/10.18097/pbmc20135903249.

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Imidazoquinolins represent a new group of compounds that recently entered into clinical practice as anti-tumor and anti-viral immune modulators. They are low molecular weight synthetic guanosine-like molecules. Although imiquimod, the most widely used imidazoquinolin, is recommended for the treatment of several forms of skin cancer and papillomas, the molecular mechanisms of its action are not fully understood. In particular, imiquimod has been characterized as a specific agonist of Toll-like receptor 7 (TLR7) and is widely used in this capacity in a large number of experimental studies and cl

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Bozrova, S. V., V. A. Levitsky, S. A. Nedospasov, and M. S. Drutskaya. "Imiquimod: The biochemical mechanisms of immunomodulatory and anti-inflammatory activity." Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry 7, no. 2 (2013): 136–45. http://dx.doi.org/10.1134/s1990750813020042.

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Panjaitan, Tina Fransiskha Carolyn, Saidun Fiddaroini, Eddy Suprayitno, Aulanni’am Aulanni’am, and Hardoko Hardoko. "Potential Analysis of Snakehead Fish Albumin Extract (Channa striata) as Immunostimulant and Anti-Inflammatory in Indomethacin-Induced Inflammatory Bowel Disease (IBD) Rats." Science and Technology Indonesia 10, no. 3 (2025): 725–40. https://doi.org/10.26554/sti.2025.10.3.725-740.

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Inflammatory Bowel Disease (IBD) is a chronic gastrointestinal disorder driven by oxidative stress and immune dysregulation, often exacerbated by prolonged non-steroidal anti-inflammatory drug (NSAID) use. Conventional therapies provide symptomatic relief but are limited by severe adverse effects, necessitating safer alternatives. Channa striata (snakehead fish) is a rich source of albumin, essential amino acids, and bioactive compounds with potential immunomodulatory and anti-inflammatory effects. This study investigates the therapeutic efficacy of purified Channa striata albumin extract in a

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Bacalbasa, Nicolae, Irina Balescu, Claudia Stoica, et al. "The anti-inflammatory, anti-infectious and anticancerous effects of Thymus vulgaris." Romanian Journal of Medical Practice 17, S3 (2022): 21–23. http://dx.doi.org/10.37897/rjmp.2022.s3.6.

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Thymus vulgaris represents a medical herb from the southern region of Europe with anti-infectious, anti-inflammatory and immunomodulatory effects. More recently an antiviral and anti-cancerous activity has been demonstrated. Therefore multiple products have been imagined in order to put in value all these properties. The aim of this paper is to discuss the mechanisms of action, properties and means of administration of this product.

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Torres-Juarez, Flor, Albertina Cardenas-Vargas, Alejandra Montoya-Rosales, et al. "LL-37 Immunomodulatory Activity during Mycobacterium tuberculosis Infection in Macrophages." Infection and Immunity 83, no. 12 (2015): 4495–503. http://dx.doi.org/10.1128/iai.00936-15.

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Tuberculosis is one of the most important infectious diseases worldwide. The susceptibility to this disease depends to a great extent on the innate immune response against mycobacteria. Host defense peptides (HDP) are one of the first barriers to counteract infection. Cathelicidin (LL-37) is an HDP that has many immunomodulatory effects besides its weak antimicrobial activity. Despite advances in the study of the innate immune response in tuberculosis, the immunological role of LL-37 duringM. tuberculosisinfection has not been clarified. Monocyte-derived macrophages were infected withM. tuberc

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Jean, Robert Klotoé. "Anti-inflammatory properties of Uvaria chamae used in traditional Beninese medicine (West Africa)." Journal of Biodiversity and Environmental Sciences (JBES) 24, no. 1 (2024): 40–50. https://doi.org/10.5281/zenodo.13770871.

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Inflammatory diseases are still a major public health concern. Their management is problematic due to the harmful side-effects of anti-inflammatory drugs traditionally used in conventional medicine. Medicinal plants are a credible source for research into new anti-inflammatory drug. This study aimed to explore the anti-inflammatory properties of the roots of <em>Uvaria chamae</em>. Anti-inflammatory activity was explored using the red blood cell membrane stability test and the formalin-induced &oelig;dema model in rats. TNFα assay was used to assess immunomodulatory activity. This m

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Yahfoufi, Nour, Nawal Alsadi, Majed Jambi, and Chantal Matar. "The Immunomodulatory and Anti-Inflammatory Role of Polyphenols." Nutrients 10, no. 11 (2018): 1618. http://dx.doi.org/10.3390/nu10111618.

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This review offers a systematic understanding about how polyphenols target multiple inflammatory components and lead to anti-inflammatory mechanisms. It provides a clear understanding of the molecular mechanisms of action of phenolic compounds. Polyphenols regulate immunity by interfering with immune cell regulation, proinflammatory cytokines’ synthesis, and gene expression. They inactivate NF-κB (nuclear factor kappa-light-chain-enhancer of activated B cells) and modulate mitogen-activated protein Kinase (MAPk) and arachidonic acids pathways. Polyphenolic compounds inhibit phosphatidylinositi

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Tripathi, Amit Kumar, and Jamboor K. Vishwanatha. "Role of Anti-Cancer Peptides as Immunomodulatory Agents: Potential and Design Strategy." Pharmaceutics 14, no. 12 (2022): 2686. http://dx.doi.org/10.3390/pharmaceutics14122686.

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The usage of peptide-based drugs to combat cancer is gaining significance in the pharmaceutical industry. The collateral damage caused to normal cells due to the use of chemotherapy, radiotherapy, etc. has given an impetus to the search for alternative methods of cancer treatment. For a long time, antimicrobial peptides (AMPs) have been shown to display anticancer activity. However, the immunomodulatory activity of anti-cancer peptides has not been researched very extensively. The interconnection of cancer and immune responses is well-known. Hence, a search and design of molecules that can sho

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Verlaet, Annelies, Nieke van der Bolt, Ben Meijer, et al. "Toll-Like Receptor-Dependent Immunomodulatory Activity of Pycnogenol®." Nutrients 11, no. 2 (2019): 214. http://dx.doi.org/10.3390/nu11020214.

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Background: Pycnogenol® (PYC), an extract of French maritime pine bark, is widely used as a dietary supplement. PYC has been shown to exert anti-inflammatory actions via inhibiting the Toll-like receptor 4 (TLR4) pathway. However, the role of the other receptors from the TLR family in the immunomodulatory activity of PYC has not been described so far. Aim: The aim of this study was to investigate whether PYC might exert its immunomodulatory properties through cell membrane TLRs (TLR1/2, TLR5, and TLR2/6) other than TLR4. Moreover, the effect of gastrointestinal metabolism on the immunomodulato

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B.J.Divya, B.Suman V. Nagalakshmamma PV Chalapathi2 and K.Thyagaraju*. "THE ANTI-INFLAMMATORY EFFECTS OF FABACEAE AND ALLIACEAE PLANTS: A REVIEW." Indo American Journal of Pharmaceutical Sciences 04, no. 11 (2017): 3856–62. https://doi.org/10.5281/zenodo.1040744.

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In the last few decades there has been an exponential growth in the field of herbal medicine and is gaining popularity among the globally developing and developed countries. Currently there has been an increased interest to identify plants and explore their therapeutic potential. The plants show pharmacological potency and have low or no side effects for use in preventive medicine and health care. Also they represent a potential source of new compounds with different pharmacological activity. Ayurveda, the oldest medicinal system in the world, finds active and therapeutically useful compounds

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Ansary, Johura. "Evaluation of the Phenolic Profile, Mineral, and Fatty Acid Content and Antioxidant Activity of Black Cumin before and after an In Vitro Simulated Gastrointestinal Digestion." Medical Sciences Forum 2, no. 1 (2020): 9. http://dx.doi.org/10.3390/cahd2020-08638.

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Black cumin (N. sativa; Ranunculaceae family) is well known for its numerous beneficial biological effects, while its seed extracts exhibit anti-diabetic, anti-cancer, immunomodulatory, anti-microbial, anti-inflammatory, anti-hypertensive and antioxidant activities [1,2]. [...]

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Alonso, Maria Rosario, Carla Marrassini, Malen Saint Martin, Laura Cogoi, Ignacio Peralta, and Claudia Anedini. "Larrea divaricataa native Argentine plant with potential activity against SARS-CoV-2?" Boletin Latinoamericano y del Caribe de Plantas Medicinales y Aromaticas 22, no. 6 (2023): 747–69. http://dx.doi.org/10.37360/blacpma.23.22.6.52.

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Larrea divaricataCav. is an autochthonous South American plant popularly used in inflammatory and infectious diseases with reported anti-inflammatory, immunomodulatory, antimicrobial and antioxidant activities. Covid-19 is an infection caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This virus can cause pneumonia and even death in about 5% of the cases. The objective of the article was to demonstrate, through a literature review, that L. divaricatahas sufficient attributes to be assayed against SARS-CoV-2. For this, the chemical composition, reported activities and

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Zhumakaeva, Ainyr Maratovna, Olga Viktorovna Maslova та Sergazy Mynzhasarovich Adekenov. "Anti-Inflammatory And Immunomodulating Activity of the 1(10) Β-Epoxy-5,7α,6β(Н)-Guai-3(4),11(13)-Dien-6,12-Olide". Open Access Macedonian Journal of Medical Sciences 12, № 3 (2024): 429–37. http://dx.doi.org/10.3889/oamjms.2024.11937.

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BACKGROUND: The article discusses the results of studies of the anti-inflammatory and immunomodulatory activity of the sesquiterpene lactone 1(10)β-epoxy-5,7α,6β(Н)-guai-3(4),11(13)-diene-6,12-olide (hereinafter referred to as epoxyguaianolide). AIM: The article discusses the results of studies of the anti-inflammatory and immunomodulatory activity of the sesquiterpene lactone 1(10)β-epoxy-5,7α,6β(Н)-guai-3(4),11(13)-diene-6,12-olide. MATERIALS AND METHODS: A non-steroidal anti-inflammatory drug diclofenac sodium at a dose of 25 mg/kg (ampoules, 2 mL each, manufactured by Germany) was used as

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Silva, Vitória R. P., Andréia C. Pinheiro, Alicia S. Ombredane, et al. "Anti-Inflammatory Activity of Pequi Oil (Caryocar brasiliense): A Systematic Review." Pharmaceuticals 17, no. 1 (2023): 11. http://dx.doi.org/10.3390/ph17010011.

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Disorders in the inflammatory process underlie the pathogenesis of numerous diseases. The utilization of natural products as anti-inflammatory agents is a well-established approach in both traditional medicine and scientific research, with studies consistently demonstrating their efficacy in managing inflammatory conditions. Pequi oil, derived from Caryocar brasiliense, is a rich source of bioactive compounds including fatty acids and carotenoids, which exhibit immunomodulatory potential. This systematic review aims to comprehensively summarize the scientific evidence regarding the anti-inflam

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Reay, Sophie L., Ana Marina Ferreira, Catharien M. U. Hilkens, and Katarina Novakovic. "The Paradoxical Immunomodulatory Effects of Chitosan in Biomedicine." Polymers 17, no. 1 (2024): 19. https://doi.org/10.3390/polym17010019.

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Chitosan is widely explored in the field of biomedicine due to its abundance and reported properties, including biocompatibility, biodegradability, non-toxicity, mucoadhesion, and anti-microbial activity. Although our understanding of the immune response to chitosan has evolved, confusion remains regarding whether chitosan is a pro- or anti-inflammatory biomaterial. Tackling this knowledge gap is essential for the translation of chitosan-based biomaterials to clinical use. Herein, we provide an overview of the immune responses to chitosan, exploring the roles of endotoxin contamination and phy

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Chang, Ting-Hui, Chien-Sheng Wu, Shih-Hwa Chiou, Chih-Hung Chang, and Hsiu-Jung Liao. "Adipose-Derived Stem Cell Exosomes as a Novel Anti-Inflammatory Agent and the Current Therapeutic Targets for Rheumatoid Arthritis." Biomedicines 10, no. 7 (2022): 1725. http://dx.doi.org/10.3390/biomedicines10071725.

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Patients with rheumatoid arthritis (RA), a chronic inflammatory joint disorder, may not respond adequately to current RA treatments. Mesenchymal stem cells (MSCs) elicit several immunomodulatory and anti-inflammatory effects and, thus, have therapeutic potential. Specifically, adipose-derived stem cell (ADSC)-based RA therapy may have considerable potency in modulating the immune response, and human adipose tissue is abundant and easy to obtain. Paracrine factors, such as exosomes (Exos), contribute to ADSCs’ immunomodulatory function. ADSC-Exo-based treatment can reproduce ADSCs’ immunomodula

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N, Lkhagvasuren, Bayar-Enkh B, Sainbileg G, et al. "Study of the anti-inflammatory and immunomodulatory activity of bovine placental extract." Mongolian Journal of Agricultural Sciences 28, no. 03 (2019): 15–25. http://dx.doi.org/10.5564/mjas.v28i03.1297.

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Many scientists study structure and charagterization of placenta and experimenting on their biological activity, due to develop new drugs and biopreparation for human and animal health. The present study aimed to isolate bovine placental lactogen from placenta by semi purification method and determine antioxidant, anti-inflamatory activity and effect on immune responses was also investigation. Semi purified protein was separated by gel-chromatographic method using 3 methods of tissue homogenizations of placental tissue using distilled water, phosphate buffer saline and Tris-HCl, by use o

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Meng, Tiantian, Dingfu Xiao, Arowolo Muhammed, Juying Deng, Liang Chen, and Jianhua He. "Anti-Inflammatory Action and Mechanisms of Resveratrol." Molecules 26, no. 1 (2021): 229. http://dx.doi.org/10.3390/molecules26010229.

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Resveratrol (3,4′,5-trihy- droxystilbene), a natural phytoalexin polyphenol, exhibits anti-oxidant, anti-inflammatory, and anti-carcinogenic properties. This phytoalexin is well-absorbed and rapidly and extensively metabolized in the body. Inflammation is an adaptive response, which could be triggered by various danger signals, such as invasion by microorganisms or tissue injury. In this review, the anti-inflammatory activity and the mechanism of resveratrol modulates the inflammatory response are examined. Multiple experimental studies that illustrate regulatory mechanisms and the immunomodul

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Krifa, Mounira, Nadia Mustapha, Zied Ghedira, Kamel Ghedira, Antonio Pizzi, and Leila Chekir-Ghedira. "Limoniastrum guyonianummethanol extract induces immunomodulatory and anti-inflammatory effects by activating cellular anti-oxidant activity." Drug and Chemical Toxicology 38, no. 1 (2014): 84–91. http://dx.doi.org/10.3109/01480545.2014.908297.

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Mokdad-Bzeouich, Imen, Nadia Mustapha, Aicha Sassi, et al. "Investigation of immunomodulatory and anti-inflammatory effects of eriodictyol through its cellular anti-oxidant activity." Cell Stress and Chaperones 21, no. 5 (2016): 773–81. http://dx.doi.org/10.1007/s12192-016-0702-8.

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Colić, M., D. Gazivoda, I. Majstorović, et al. "Immunomodulatory Activity of IL-27 in Human Periapical Lesions." Journal of Dental Research 88, no. 12 (2009): 1142–47. http://dx.doi.org/10.1177/0022034509351407.

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IL-27, a cytokine with pro-inflammatory and anti-inflammatory properties, is a new member of the IL-6/IL-12 family, whose function in periapical lesions is unknown. We hypothesized that the production of IL-27 and its effect depend upon the type of immune/inflammatory response and clinical presentation of periapical lesions. We tested this hypothesis by studying the expression and function of IL-27 in human periapical lesions, both in situ and in culture. Immunohistochemistry demonstrated the strongest expression of IL-27 by endothelial cells and mononuclear phagocytes. Its production by peria

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Jitendra, Sunte, and B. Pratapur Satish. "Medicinal Tooth paste and Tooth powder." Journal of Advanced Research and Reviews in Medical & Medicine 2, no. 1 (2025): 1–4. https://doi.org/10.5281/zenodo.15086825.

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<em>Uttarani tree herb, mango tree, water tree, fig tree, banyan tree, neem tree, jack fruit also medicinal trees used in toothpaste which are Anti-oxidant, Anti-diabetic, Antiviral activity, Anthelmintic and anti-allergenic activity, Antiparasitic activity, Antibone resorption, Anti-tumor-anti-HIV, Antispasmodic and antipyretic activity, Anti-inflammatory, Anti-bacterial and antifungal activity, Anti-microbial, Immunomodulatory, Hepatoprotective, Gastroprotective, Antitumor activity, Hypolipidemic activity. Parts of tree are Flowers, Fruits, Seeds, Stem , bark, twig, branches etc .used for pr

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Djaldetti, Meir. "Piperine – An Immunomodulator and Inflammation Mitigator." Journal of Clinical and Laboratory Research 2, no. 5 (2021): 01–04. http://dx.doi.org/10.31579/2768-0487/027.

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Black pepper, one of the most widespread spices, gained the entitlement “King of spices” founded on its peculiar pungent test and therapeutic properties, both owed to its active alkaloid - piperine. Mounting evidence indicates that piperine possesses immunomodulatory and therapeutic activities. The aim of this mini review was to summarize the role of piperine in abolishing inflammation, its part in the immune activity of peripheral blood mononuclear- and a number of other cells, its capacity to elicit production of inflammatory cytokines and its function as a synergist endorsing the beneficial

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Mahajan, Jyoti, Pragya Shrivatava, and Manik Sharma. "Immunomodulatory Activity of Methanol Extract of Asparagus racemosus." International Journal of Research and Innovation in Applied Science X, no. V (2025): 916–20. https://doi.org/10.51584/ijrias.2025.100500081.

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Asparagus racemosus, or Shatavari, is a medicinally important Ayurvedic plant whose traditional uses include immunomodulatory and rejuvenating effects. In the current study, immunomodulatory effect of methanol root extract of Asparagus racemosus (ArM) was screened by in vitro and in vivo experiments. Murine splenocytes proliferation was assessed by MTT assay following the effect of extract. Cytokine production (TNF-α, IL-6, and IL-10) was also examined using ELISA. Furthermore, ArM’s impact on peritoneal macrophage phagocytic activity was assessed. In vivo, the extract was orally given to mice

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Matsuura, Motohiro, Hideyuki Takahashi, Haruo Watanabe, Shinji Saito, and Kazuyoshi Kawahara. "Immunomodulatory Effects of Yersinia pestis Lipopolysaccharides on Human Macrophages." Clinical and Vaccine Immunology 17, no. 1 (2009): 49–55. http://dx.doi.org/10.1128/cvi.00336-09.

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ABSTRACTIn the current study, we investigated the activity of lipopolysaccharide (LPS) purified fromYersinia pestisgrown at either 27°C or 37°C (termed LPS-27 and LPS-37, respectively). LPS-27 containing hexa-acylated lipid A, similar to the LPS present in usual gram-negative bacteria, stimulated an inflammatory response in human U937 cells through Toll-like receptor 4 (TLR4). LPS-37, which did not contain hexa-acylated lipid A, exhibited strong antagonistic activity to the TLR4-mediated inflammatory response. The phagocytic activity in the cells was not affected by LPS-37. To estimate the act

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El-anssary, Amira A., Gehan Fawzy Abdel Raoof, Dalia Osama Saleh, and Hossam Mohammed El-Masry. "Bioactivities, physicochemical parameters and GC/MS profiling of the fixed oil of Cucumis melo L seeds: A focus on anti-inflammatory, immunomodulatory, and antimicrobial activities." Journal of Herbmed Pharmacology 10, no. 4 (2021): 476–85. http://dx.doi.org/10.34172/jhp.2021.55.

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Introduction: Recently, the recovery of waste products from plants as a source of biologically active compounds has increased interest. Therefore, the current research aims to evaluate the anti-inflammatory, immunomodulatory and antimicrobial activities of the fixed oil of Cucumis melo L seeds, as well as to investigate its physicochemical parameters and chemical composition. Methods: Anti-inflammatory activity was examined using carrageenan-induced rat paw edema assay. The antimicrobial activity was assayed against Staphylococcus aureus, Micrococcus luteus, Enterococcus faecalis, Staphylococc

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Lee, Jieun, Moon Hee Choi, Eun-su Jang, Hyun-Jae Shin, and Jung Heon Lee. "Polysaccharide from Hizikia Fusiformis Enhances the Immunomodulatory Activity of Macrophages." Journal of Rhinology 27, no. 1 (2020): 8–15. http://dx.doi.org/10.18787/jr.2018.00277.

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Background and Objectives: <i>Hizikia fusiformis</i> is widely used in oriental health food in Japan, China, and Korea, and is known for its anti-oxidation properties.Materials and Method: In this study, we investigated the anti-inflammatory and immune-modulatory effects and mechanisms of <i>Hizikia fusiformis</i> (<i>H. fusiformis</i>) extracts in lipopolysaccharide (LPS)-treated RAW 264.7 cells. RAW 264.7 cells were incubated in the presence of different concentrations of the viscozyme component of <i>H. fusiformis</i> (1, 2, 5, and 10 μg/mL),

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Mubashir, Khan, Bashir A. Ganai, Khalid Ghazanfar, Seema Akbar, Akhtar H. Malik, and Akbar Masood. "Evaluation of Artemisia amygdalina D. for Anti-Inflammatory and Immunomodulatory Potential." ISRN Inflammation 2013 (October 10, 2013): 1–5. http://dx.doi.org/10.1155/2013/483646.

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Artemisia amygdalina D. is a critically endangered endemic medicinal plant of Kashmir Himalayas. In the current study anti-inflammatory and immunomodulatory activity of the plant was carried out. Carrageenan paw edema model was used to study the potential of the drug in inflammation in Wistar rats. SRBC-specific haemagglutination titre and DTH assays were carried out in Balb/C mice for observing the effect of test drugs on immune system. The plant extracts used as test drugs showed to have anti-inflammatory potential. The methanolic fraction was observed to have the maximum effect on the inhib

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Kilani-Jaziri, Soumaya, Nadia Mustapha, Imen Mokdad-Bzeouich, Dorra El Gueder, Kamel Ghedira, and Leila Ghedira-Chekir. "Flavones induce immunomodulatory and anti-inflammatory effects by activating cellular anti-oxidant activity: a structure-activity relationship study." Tumor Biology 37, no. 5 (2015): 6571–79. http://dx.doi.org/10.1007/s13277-015-4541-5.

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Cerveró-Varona, A., A. Canciello, G. Prencipe, et al. "THE SECRETOME OF AEC: CHALLENGES AND OPPORTUNITIES IN CELL-FREE REGENERATIVE MEDICINE IN TENDON DISORDERS." Orthopaedic Proceedings 106-B, SUPP_2 (2024): 47. http://dx.doi.org/10.1302/1358-992x.2024.2.047.

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The application of immune regenerative strategies to deal with unsolved pathologies, such as tendinopathies, is getting attention in the field of tissue engineering exploiting the innate immunomodulatory potential of stem cells [1]. In this context, Amniotic Epithelial Cells (AECs) represent an innovative immune regenerative strategy due to their teno-inductive and immunomodulatory properties [2], and because of their high paracrine activity, become a potential stem cell source for a cell-free treatment to overcome the limitations of traditional cell-based therapies. Nevertheless, these immuno

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Shavlovskaya, O. A., Yu D. Yukhnovskaya, I. D. Romanov, and I. A. Bokova. "Pharmaconutraceutical Chondroguard®TRIO – chondroprotector with immunomodulatory activity." Neurology, Neuropsychiatry, Psychosomatics 15, no. 4 (2023): 105–11. http://dx.doi.org/10.14412/2074-2711-2023-4-105-111.

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Understanding the major pathological pathways and the key molecules involved in the pathogenesis of inflammatory processes in joints, particularly in osteoarthritis (OA), is crucial for drug and pharmaconutraceuticals development. OA is a degenerative joint disease that predominantly affects articular cartilage. Destruction of hyaline cartilage and restructuring of subchondral bone are accompanied by synovial inflammation in the joint, including the facet joint of the spine, manifested by pain in the joint, low back pain (LBP), and limitation of functional activity. The article discusses the r

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Li, Hanxiao, Junhui Niu, Xiaoli Wang, Mingfu Niu, and Chengshui Liao. "The Contribution of Antimicrobial Peptides to Immune Cell Function: A Review of Recent Advances." Pharmaceutics 15, no. 9 (2023): 2278. http://dx.doi.org/10.3390/pharmaceutics15092278.

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The development of novel antimicrobial agents to replace antibiotics has become urgent due to the emergence of multidrug-resistant microorganisms. Antimicrobial peptides (AMPs), widely distributed in all kingdoms of life, present strong antimicrobial activity against a variety of bacteria, fungi, parasites, and viruses. The potential of AMPs as new alternatives to antibiotics has gradually attracted considerable interest. In addition, AMPs exhibit strong anticancer potential as well as anti-inflammatory and immunomodulatory activity. Many studies have provided evidence that AMPs can recruit an

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Greeshma G Nair та Sathianarayanan S. "Syzygium Samarangense : A Review on its Pharmacognostical, Pharmacological and Phytochemical Proৎile". International Journal of Research in Pharmaceutical Sciences 11, № 4 (2020): 6066–78. http://dx.doi.org/10.26452/ijrps.v11i4.3276.

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The objective of this review is to document briefly about the chemical constituents, pharmacognostical evaluation and biological activities of Syzygium samarangense belongs to the family Myrtaceae. It is generally called Java Apple, Wax Apple, Blume, Chambekka etc. Syzygium samarangense traditionally used as an astringent. It is also used to treat fever and halt diarrhea. The whole plant contains flavonoids, terpenoids, tannins, phenolic compounds, gallic acid, ellagic acid, squalene, botulin, lupeol, sitosterol, mixture of cycloartenol stearate, lupenyl stearate, β-sitosterol stearate, vitami

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Limsakul, Praopim, Pemikar Srifa, Ziliang Huang, Linshan Zhu, Yiqian Wu, and Krit Charupanit. "Immunomodulatory Effects of Curcumin on CAR T-Cell Therapy." Antioxidants 14, no. 4 (2025): 454. https://doi.org/10.3390/antiox14040454.

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Chimeric Antigen Receptor (CAR) T-cell therapy has revolutionized the treatment of hematological malignancies, demonstrating high efficacy in targeting and eliminating cancer cells. However, its clinical application can be associated with the risk of acute adverse effects, including cytokine release syndrome (CRS), a severe inflammatory response caused by excessive cytokine production. While anti-cytokine therapies are available to manage CRS, additional strategies are needed to optimize CAR T-cell efficacy with reduced toxicities. Curcumin, a bioactive polyphenol known for its anti-inflammato

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Majdalawieh, Amin F., Bayan K. Khatib та Tala M. Terro. "α-Mangostin Is a Xanthone Derivative from Mangosteen with Potent Immunomodulatory and Anti-Inflammatory Properties". Biomolecules 15, № 5 (2025): 681. https://doi.org/10.3390/biom15050681.

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α-Mangostin, a bioactive xanthone derived from the Garcinia mangostana L. Clusiaceae (G. mangostana) fruit, has demonstrated significant anti-inflammatory and immunomodulatory properties. Chronic inflammation plays a critical role in the pathogenesis of various diseases, including metabolic disorders, autoimmune conditions, and cancer. Conventional anti-inflammatory therapies, such as non-steroidal anti-inflammatory drugs (NSAIDs), often carry undesirable side effects, prompting the need for safer, natural alternatives. This review consolidates the existing literature on the mechanisms by whic

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Saad, Bashar. "Immunomodulatory and Anti-Inflammatory Properties of Honey and Bee Products." Immuno 5, no. 2 (2025): 19. https://doi.org/10.3390/immuno5020019.

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Honey and other bee products, including propolis, royal jelly, and bee pollen, are widely recognized for their medicinal properties. Among their numerous biological activities, their anti-inflammatory and immunomodulatory effects have gained significant attention in recent years. Immune and inflammatory disorders contribute significantly to the development of chronic conditions, including cancer and diabetes. Bee-derived products, along with their bioactive compounds such as polyphenols, have shown promising therapeutic effects in modulating inflammatory mediators. Studies indicate that these

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Santander, Sandra Paola, John Fredy Hernández, Claudia Cifuentes B, Masayuki Aoki, Helene Moins-Teisserenc, and Susana Fiorentino. "Immunomodulatory Effects of Aqueous and Organic Fractions from Petiveria alliacea on Human Dendritic Cells." American Journal of Chinese Medicine 40, no. 04 (2012): 833–44. http://dx.doi.org/10.1142/s0192415x12500620.

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Petiveria alliacea is a plant traditionally known for its anti-inflammatory and anti-tumor activities; however, the molecular and cellular mechanisms of its immunomodulatory properties are still unknown. Dendritic cells (DC) promote adaptive immune response by activating T lymphocytes, inducing an effector response or tolerance depending on the DC differentiation level. Herein, we evaluated the immunomodulatory activity of aqueous and organic plant fractions from P. alliacea using human monocyte-derived dendritic cells. The phenotype, cytokine secretion and gene expression were estimated after

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Kraiem, Marwa, Sonia Ben Hamouda, Malek Eleroui, et al. "Anti-Inflammatory and Immunomodulatory Properties of a Crude Polysaccharide Derived from Green Seaweed Halimeda tuna: Computational and Experimental Evidences." Marine Drugs 22, no. 2 (2024): 85. http://dx.doi.org/10.3390/md22020085.

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In this study, we investigated for the first time the anti-inflammatory and immunomodulatory properties of crude polysaccharide (PSHT) extracted from green marine algae Halimeda tuna. PSHT exhibited anti-oxidant activity in vitro through scavenging 1, 1-diphenyl-2-picryl hydroxyl free radical, reducing Fe3+/ferricyanide complex, and inhibiting nitric oxide. PSHT maintained the erythrocyte membrane integrity and prevented hemolysis. Our results also showed that PSHT exerted a significant anti-edematic effect in vivo by decreasing advanced oxidation protein products and malondialdehyde levels an

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Akindele, Abidemi J., Abimbola Sowemimo, Foluso O. Agunbiade, et al. "Bioprospecting for Anti-COVID-19 Interventions From African Medicinal Plants: A Review." Natural Product Communications 17, no. 5 (2022): 1934578X2210969. http://dx.doi.org/10.1177/1934578x221096968.

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The emergence of the novel coronavirus (SARS-CoV-2) that emanated from Wuhan in China in 2019 has become a global concern. The current situation warrants ethnomedicinal drug discovery and development for delivery of phytomedicines with potential for the treatment of COVID-19. The aim of this review is to provide a detailed evaluation of available information on plant species used in African traditional medicines with antiviral, anti-inflammatory, immunomodulatory, and COVID-19 symptoms relieving effects. Literature from scientific databases such as Scopus, PubMed, Google scholar, African Journ

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Shukla, Aparna, Pooja Sharma, Om Prakash, et al. "QSAR and Docking Studies on Capsazepine Derivatives for Immunomodulatory and Anti-Inflammatory Activity." PLoS ONE 9, no. 7 (2014): e100797. http://dx.doi.org/10.1371/journal.pone.0100797.

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Zapata Lopera, Yury Maritza, Enrique Jiménez-Ferrer, Maribel Herrera-Ruiz, et al. "New Chromones from Bouvardia ternifolia (Cav.) Schltdl with Anti-Inflammatory and Immunomodulatory Activity." Plants 12, no. 1 (2022): 1. http://dx.doi.org/10.3390/plants12010001.

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The extract, fractions, and compounds of the Bouvardia ternifolia root were evaluated as an antiarthritic using a complete Freund’s adjuvant (CFA) model in mice and NF-κB inhibition in RAW 264.7 macrophages. Four active compounds, including two new compounds, ternifoliol and ternifolial, were isolated by open column chromatography and identified by spectroscopic and spectrometric techniques, resulting in benzochromone-like structures with aromatic rings and hydroxyl groups, which could be responsible for the anti-inflammatory activity and inhibitory NF-κB. Changes in the joint cytokine profile

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Harnett, M. M., D. E. Kean, A. Boitelle, et al. "The phosphorycholine moiety of the filarial nematode immunomodulator ES-62 is responsible for its anti-inflammatory action in arthritis." Annals of the Rheumatic Diseases 67, no. 4 (2007): 518–23. http://dx.doi.org/10.1136/ard.2007.073502.

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Objective:In countries where parasitic infections are endemic, autoimmune disease is relatively rare, leading to the hypothesis that parasite-derived immunomodulators may protect against its development. Consistent with this, we have previously demonstrated that ES-62, a 62 kDa phosphorylcholine (PC)-containing glycoprotein that is secreted by filarial nematodes, can exert anti-inflammatory action in the murine collagen-induced arthritis (CIA) model and human rheumatoid arthritis-derived synovial tissue cultures. As a first step to developing ES-62-based drugs, the aim of this study was to det

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